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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MKNK1 (NCBI Gene ID:8569)

Gene Summary

Gene Summary

Gene Information	Gene Name: MKNK1
	Gene ID: 8569
	Gene Symbol	MKNK1
	Gene ID	8569
	Gene Name	MAPK interacting serine/threonine kinase 1
	Synonyms	MNK1
	Cytomap	1p33
	Type of Gene	protein-coding
	Description	MAP kinase-interacting serine/threonine-protein kinase 1MAP kinase interacting serine/threonine kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1
	Modification date	20200327
	UniProtAcc	Q9BUB5

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MKNK1	GO:0006468	protein phosphorylation	9155018
Hgene	MKNK1	GO:0018105	peptidyl-serine phosphorylation	17130135
Hgene	MKNK1	GO:0035556	intracellular signal transduction	9155018

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'MKNK1[title] AND translation [title] AND human.'

Gene	Title	PMID
MKNK1	FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression	31894299

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000371946	47025905	47025949	Frame-shift
ENST00000371946	47028320	47028515	In-frame
ENST00000371946	47037088	47037211	In-frame
ENST00000371946	47040618	47040692	Frame-shift
ENST00000371946	47046201	47046299	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000371946	47028320	47028515	2736	933	1127	465	256	321
ENST00000371946	47037088	47037211	2736	658	780	465	164	205

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9BUB5	256	321	1	465	Chain	ID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
Q9BUB5	164	205	1	465	Chain	ID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
Q9BUB5	256	321	49	374	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BUB5	164	205	49	374	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9BUB5	164	205	165	205	Alternative sequence	ID=VSP_007352;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15350534,ECO:0000303\|PubMed:9155018;Dbxref=PMID:15350534,PMID:9155018
Q9BUB5	256	321	308	308	Natural variant	ID=VAR_040803;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55791614,PMID:17344846
Q9BUB5	256	321	271	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2HW6
Q9BUB5	256	321	277	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2HW6

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	MKNK1	-1.7724058315911	0.000119179323433261
LUAD	MKNK1	-1.64881335054025	0.000184346986492713
KIRP	MKNK1	-1.83550648151309	0.00608485564589501
KIRC	MKNK1	-1.36155431828684	4.53899662243056e-11

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	MKNK1	hsa-miR-497-5p	99	-0.334990749306198	0.0218151554907431

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PAAD	MKNK1	-0.37363847	0.028366944

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MKNK1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
LGG	Cell metabolism gene	MKNK1	PLCB2	0.823596424	3.87E-132
LGG	IUPHAR	MKNK1	PLCB2	0.823596424	3.87E-132
THYM	Cell metabolism gene	MKNK1	PLCG1	0.800874638	1.71E-28
THYM	Cell metabolism gene	MKNK1	DGKA	0.801416693	1.48E-28
THYM	Cell metabolism gene	MKNK1	PDE7A	0.804673282	6.07E-29
THYM	Cell metabolism gene	MKNK1	SLC23A1	0.806421072	3.75E-29
THYM	Cell metabolism gene	MKNK1	EDEM1	0.807558697	2.73E-29
THYM	Cell metabolism gene	MKNK1	PAFAH2	0.815903809	2.49E-30
THYM	CGC	MKNK1	PLCG1	0.800874638	1.71E-28
THYM	CGC	MKNK1	ITK	0.801067361	1.62E-28
THYM	CGC	MKNK1	IKZF1	0.829527434	3.81E-32
THYM	CGC	MKNK1	MDM4	0.8316069	1.95E-32
THYM	CGC	MKNK1	FNBP1	0.837829907	2.47E-33
THYM	Epifactor	MKNK1	GFI1	0.805634782	4.66E-29
THYM	Epifactor	MKNK1	IKZF1	0.829527434	3.81E-32
THYM	Epifactor	MKNK1	MSL3	0.844080492	2.85E-34
THYM	IUPHAR	MKNK1	PLCG1	0.800874638	1.71E-28
THYM	IUPHAR	MKNK1	ITK	0.801067361	1.62E-28
THYM	IUPHAR	MKNK1	PDE7A	0.804673282	6.07E-29
THYM	IUPHAR	MKNK1	SLC23A1	0.806421072	3.75E-29
THYM	IUPHAR	MKNK1	PAFAH2	0.815903809	2.49E-30
THYM	IUPHAR	MKNK1	LAIR1	0.819415327	8.77E-31
THYM	IUPHAR	MKNK1	IRAK4	0.823241544	2.74E-31
THYM	IUPHAR	MKNK1	CD4	0.823897509	2.24E-31
THYM	IUPHAR	MKNK1	NLRC3	0.834892754	6.62E-33
THYM	IUPHAR	MKNK1	SLC7A6	0.854661094	5.85E-36
THYM	IUPHAR	MKNK1	CYP2U1	0.857509817	1.95E-36
THYM	Kinase	MKNK1	ITK	0.801067361	1.62E-28
THYM	Kinase	MKNK1	IRAK4	0.823241544	2.74E-31
THYM	TF	MKNK1	GFI1	0.805634782	4.66E-29
THYM	TF	MKNK1	IKZF1	0.829527434	3.81E-32
THYM	TSG	MKNK1	CD4	0.823897509	2.24E-31
THYM	TSG	MKNK1	IKZF1	0.829527434	3.81E-32
UCS	Cell metabolism gene	MKNK1	PLCG1	0.800874638	1.71E-28
UCS	Cell metabolism gene	MKNK1	DGKA	0.801416693	1.48E-28
UCS	Cell metabolism gene	MKNK1	PDE7A	0.804673282	6.07E-29
UCS	Cell metabolism gene	MKNK1	SLC23A1	0.806421072	3.75E-29
UCS	Cell metabolism gene	MKNK1	EDEM1	0.807558697	2.73E-29
UCS	Cell metabolism gene	MKNK1	PAFAH2	0.815903809	2.49E-30
UCS	CGC	MKNK1	PLCG1	0.800874638	1.71E-28
UCS	CGC	MKNK1	ITK	0.801067361	1.62E-28
UCS	CGC	MKNK1	IKZF1	0.829527434	3.81E-32
UCS	CGC	MKNK1	MDM4	0.8316069	1.95E-32
UCS	CGC	MKNK1	FNBP1	0.837829907	2.47E-33
UCS	Epifactor	MKNK1	GFI1	0.805634782	4.66E-29
UCS	Epifactor	MKNK1	IKZF1	0.829527434	3.81E-32
UCS	Epifactor	MKNK1	MSL3	0.844080492	2.85E-34
UCS	IUPHAR	MKNK1	PLCG1	0.800874638	1.71E-28
UCS	IUPHAR	MKNK1	ITK	0.801067361	1.62E-28
UCS	IUPHAR	MKNK1	PDE7A	0.804673282	6.07E-29
UCS	IUPHAR	MKNK1	SLC23A1	0.806421072	3.75E-29
UCS	IUPHAR	MKNK1	PAFAH2	0.815903809	2.49E-30
UCS	IUPHAR	MKNK1	LAIR1	0.819415327	8.77E-31
UCS	IUPHAR	MKNK1	IRAK4	0.823241544	2.74E-31
UCS	IUPHAR	MKNK1	CD4	0.823897509	2.24E-31
UCS	IUPHAR	MKNK1	NLRC3	0.834892754	6.62E-33
UCS	IUPHAR	MKNK1	SLC7A6	0.854661094	5.85E-36
UCS	IUPHAR	MKNK1	CYP2U1	0.857509817	1.95E-36
UCS	Kinase	MKNK1	ITK	0.801067361	1.62E-28
UCS	Kinase	MKNK1	IRAK4	0.823241544	2.74E-31
UCS	TF	MKNK1	GFI1	0.805634782	4.66E-29
UCS	TF	MKNK1	IKZF1	0.829527434	3.81E-32
UCS	TSG	MKNK1	CD4	0.823897509	2.24E-31
UCS	TSG	MKNK1	IKZF1	0.829527434	3.81E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	MKNK1	MAPK1	1.27319002595358	0.000911891460418701
BRCA	MKNK1	MAPK3	-1.61909976139263	0.00193136402459222
KIRC	MKNK1	SPRY2	-2.59697267350469	0.00224635330560483
CHOL	MKNK1	MAPK3	-1.54068193424676	0.00390625
ESCA	MKNK1	PLA2G4A	2.72869699779812	0.0048828125
KICH	MKNK1	EIF4G1	-1.46656081150743	0.00612920522689819
LUAD	MKNK1	PPP2CA	-2.59279455680557	0.00847843979516537
KICH	MKNK1	PLA2G4A	-3.72927591791215	0.0135546922683716
ESCA	MKNK1	MAPK1	-1.17755474324053	0.0185546875
KIRC	MKNK1	PPP2CA	-1.27046306822435	0.0253347545755805
ESCA	MKNK1	EIF4A1	-1.24538073199285	0.0419921875
ESCA	MKNK1	SPRY2	2.51618835128384	0.0419921875
BRCA	MKNK1	MAPK1	-1.67954875219151	0.0427276834041307
THCA	MKNK1	PLA2G4A	1.74612400507597	1.06211531258311e-06
BRCA	MKNK1	MAPK14	-1.6928131480761	1.08867679255958e-06
PRAD	MKNK1	PLA2G4A	-2.47749288299188	1.18254481038506e-06
PRAD	MKNK1	MAPK14	1.20273850965986	2.06740855708439e-05
LIHC	MKNK1	MAPK11	-2.04244177410399	2.35319665208461e-06
LUAD	MKNK1	SPRY2	-2.77669688639422	4.00021479245452e-09
COAD	MKNK1	MAPK3	-1.17173283146352	5.66244125366212e-07
KICH	MKNK1	EIF4E	1.61675210562671	6.55651092529297e-06
LUAD	MKNK1	PLA2G4A	1.7409850004622	7.52266307692291e-07
KICH	MKNK1	EIF4A1	1.14485583309571	8.16583633422851e-06
THCA	MKNK1	MAPK11	-4.04478616286993	8.27580425414032e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MKNK1

FANCA, MAPK1, EIF4E, EIF4G1, EIF4G2, MAPK3, MAPK14, CREBBP, HSP90AB1, PRKDC, DNAJC7, EIF4G3, DDAH2, ATXN3, UBE2D1, PHAX, SPRY2, APP, RCN3, TNIP2, HGS, HIPK2, MAPK11, MOV10, XPO1, ID1, LLGL2, PDK1, PPIA, RAB5A, MYH13, KIF1C, RNASEH2B, KIF18A, PARD6B, BOD1L1, Flot1, Nek2, Itsn2, Cul1, Mkln1, Pdlim5, Chmp4c, Sept7, Wiz, Dennd6a, Rhoa, PAK2, TRIM25, EGLN3, CREM, CCL16, BPIFA1, AHNAK2, TNFRSF1B, AMOTL2, ABHD10,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MKNK1	BLCA	chr1	47024330	47024330	G	A	Missense_Mutation	p.P439S	3
MKNK1	ESCA	chr1	47027176	47027176	C	T	Missense_Mutation	p.V368I	3
MKNK1	LIHC	chr1	47028365	47028365	C	T	Missense_Mutation		3
MKNK1	HNSC	chr1	47046281	47046281	G	A	Missense_Mutation	p.S52F	3
MKNK1	LIHC	chr1	47028365	47028365	C	T	Missense_Mutation	p.A307T	3
MKNK1	UCEC	chr1	47027214	47027214	A	G	Missense_Mutation	p.L355P	3
MKNK1	SKCM	chr1	47042299	47042299	G	A	Missense_Mutation	p.R88W	3
MKNK1	UCEC	chr1	47059838	47059838	A	C	RNA	NULL	2
MKNK1	STAD	chr1	47027233	47027233	C	A	Missense_Mutation	p.D349Y	2
MKNK1	LGG	chr1	47024299	47024299	G	A	Missense_Mutation		2
MKNK1	LUAD	chr1	47028476	47028476	C	A	Missense_Mutation	p.V270F	2
MKNK1	BLCA	chr1	47024307	47024307	C	T	Silent	p.R446R	2
MKNK1	ESCA	chr1	47027176	47027176	C	T	Missense_Mutation		2
MKNK1	ACC	chr1	47028362	47028362	C	T	Missense_Mutation	p.D308N	2
MKNK1	KIRC	chr1	47028508	47028508	G	C	Missense_Mutation	p.S259C	2
MKNK1	THYM	chr1	47028358	47028358	C	T	Missense_Mutation	p.C309Y	2
MKNK1	LIHC	chr1	47030714	47030714	G	-	Splice_Site	p.P256_splice	2
MKNK1	SKCM	chr1	47024335	47024335	G	A	Missense_Mutation	p.S437F	2
MKNK1	SKCM	chr1	47048920	47048920	G	A	Missense_Mutation	p.S39F	2
MKNK1	STAD	chr1	47024441	47024441	C	T	Missense_Mutation		2
MKNK1	CESC	chr1	47059806	47059806	G	C	Missense_Mutation		2
MKNK1	UCEC	chr1	47025946	47025946	C	T	Missense_Mutation	p.A378T	2
MKNK1	LUAD	chr1	47030775	47030775	C	T	Missense_Mutation	p.G236S	2
MKNK1	STAD	chr1	47024441	47024441	C	T	Missense_Mutation	p.A402T	2
MKNK1	CESC	chr1	47059806	47059806	G	C	Missense_Mutation	p.Q5E	2
MKNK1	UCEC	chr1	47042321	47042321	G	A	Missense_Mutation	p.S10L	2
MKNK1	STAD	chr1	47024370	47024370	C	A	Missense_Mutation	p.E425D	2
MKNK1	LGG	chr1	47030791	47030791	G	T	Silent	p.I230I	1
MKNK1	SKCM	chr1	47046283	47046283	G	A	Silent	p.T51T	1
MKNK1	BLCA	chr1	47025942	47025942	G	A	Missense_Mutation		1
MKNK1	LUAD	chr1	47024441	47024441	C	G	Missense_Mutation	p.A402P	1
MKNK1	COAD	chr1	47046212	47046212	T	C	Missense_Mutation	p.Y75C	1
MKNK1	SARC	chr1	47037813	47037813	G	T	Missense_Mutation		1
MKNK1	SKCM	chr1	47027272	47027272	G	A	Missense_Mutation	p.P336S	1
MKNK1	STAD	chr1	47046273	47046273	G	A	Missense_Mutation	p.L55F	1
MKNK1	SARC	chr1	47059849	47059849	G	T	Missense_Mutation		1
MKNK1	LGG	chr1	47030791	47030791	G	T	Silent		1
MKNK1	SKCM	chr1	47042306	47042306	C	T	Missense_Mutation	p.G15D	1
MKNK1	LUAD	chr1	47037739	47037739	G	C	Silent	p.T163T	1
MKNK1	STAD	chr1	47030770	47030770	A	G	Silent	p.S237S	1
MKNK1	SARC	chr1	47028460	47028460	G	T	Missense_Mutation		1
MKNK1	SKCM	chr1	47027158	47027158	C	T	Missense_Mutation	p.V374M	1
MKNK1	BLCA	chr1	47024297	47024297	G	C	Missense_Mutation	p.L450V	1
MKNK1	LUAD	chr1	47040664	47040664	C	T	Missense_Mutation	p.E115K	1
MKNK1	THYM	chr1	47046238	47046238	G	A	Silent		1
MKNK1	HNSC	chr1	47046281	47046281	G	A	Missense_Mutation		1
MKNK1	SARC	chr1	47030724	47030724	G	T	Missense_Mutation		1
MKNK1	LIHC	chr1	47037757	47037757	G	T	Silent		1
MKNK1	BLCA	chr1	47040641	47040641	C	A	Missense_Mutation	p.L122F	1
MKNK1	OV	chr1	46821527	46821527	C	A	Silent	p.R32	1
MKNK1	SARC	chr1	47051606	47051606	G	A	Silent	p.V25	1
MKNK1	THYM	chr1	47028358	47028358	C	T	Missense_Mutation		1
MKNK1	LIHC	chr1	47048993	47048993	T	G	Missense_Mutation	p.S15R	1
MKNK1	BLCA	chr1	47028503	47028503	C	T	Missense_Mutation	p.E261K	1
MKNK1	OV	chr1	46806722	46806722	A	G	Silent	p.L218	1
MKNK1	HNSC	chr1	47025908	47025908	C	T	Silent	p.Q390Q	1
MKNK1	SKCM	chr1	47042306	47042306	C	T	Silent	p.G85G	1
MKNK1	THYM	chr1	47046238	47046238	G	A	Silent	p.A66A	1
MKNK1	BLCA	chr1	47025942	47025942	G	A	Missense_Mutation	p.P379L	1
MKNK1	OV	chr1	46813221	46813221	C	G	Missense_Mutation	p.E125Q	1
MKNK1	SKCM	chr1	47034134	47034134	A	C	Missense_Mutation	p.L177W	1
MKNK1	BLCA	chr1	47024330	47024330	G	A	Missense_Mutation		1
MKNK1	BLCA	chr1	47024369	47024369	C	-	Frame_Shift_Del	p.A426fs	1
MKNK1	OV	chr1	47051647	47051647	C	C	Splice_Site	e1-1	1
MKNK1	LGG	chr1	47024299	47024299	G	A	Missense_Mutation	p.A408V	1
MKNK1	BLCA	chr1	47024307	47024307	C	T	Silent		1
MKNK1	LIHC	chr1	47024268	47024268	C	-	Frame_Shift_Del	p.R459fs	1
MKNK1	PAAD	chr1	47030758	47030758	C	A	Silent		1
MKNK1	LGG	chr1	47024299	47024299	G	A	Missense_Mutation	p.A449V	1
MKNK1	BLCA	chr1	47024369	47024369	C	-	Frame_Shift_Del		1
MKNK1	PAAD	chr1	47024308	47024308	C	T	Missense_Mutation		1
MKNK1	LGG	chr1	47024399	47024399	C	T	Missense_Mutation	p.E416K	1
MKNK1	SKCM	chr1	47034134	47034134	A	C	Missense_Mutation	p.L218W	1
MKNK1	BLCA	chr1	47028503	47028503	C	T	Missense_Mutation		1
MKNK1	LUAD	chr1	47037778	47037778	C	G	Silent	p.V150V	1
MKNK1	COAD	chr1	47042283	47042283	C	T	Missense_Mutation	p.R93Q	1
MKNK1	READ	chr1	47046209	47046209	G	T	Missense_Mutation	p.A76D	1

Copy number variation (CNV) of MKNK1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MKNK1
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
60839	LUAD	TCGA-55-8506-01A	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
60839	LUAD	TCGA-55-8506-01A	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
60839	OV	TCGA-13-0893-01B	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
60839	OV	TCGA-24-1428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
92208	OV	TCGA-13-0893-01B	MKNK1	chr1	47082383	-	EFCAB14	chr1	47131036	-
92208	UCEC	TCGA-KP-A3W4-01A	MKNK1	chr1	47082383	-	EFCAB14	chr1	47182115	-
54098	N/A	BG898608	MKNK1	chr1	47023089	-	MKNK1-AS1	chr1	47023171	+
71598	N/A	BM151930	PSD3	chr8	18793632	-	MKNK1	chr1	47063141	+
71598	SARC	TCGA-DX-AB2O-01A	RABIF	chr1	202858101	-	MKNK1	chr1	47059952	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	MKNK1	0.00761050940955113	0.21
LUAD	MKNK1	0.0377613283984948	1
LIHC	MKNK1	0.0485192436426276	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
GBM	MKNK1	0.0355976892697527	1
LGG	MKNK1	0.0212539517282568	0.66
BRCA	MKNK1	0.00264765387832764	0.085
THYM	MKNK1	0.000102138717709065	0.0034

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
C0038580	Substance Dependence	1	CTD_human
C0740858	Substance abuse problem	1	CTD_human