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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MKNK1 (NCBI Gene ID:8569)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MKNK1
Gene ID: 8569
Gene Symbol

MKNK1

Gene ID

8569

Gene NameMAPK interacting serine/threonine kinase 1
SynonymsMNK1
Cytomap

1p33

Type of Geneprotein-coding
DescriptionMAP kinase-interacting serine/threonine-protein kinase 1MAP kinase interacting serine/threonine kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1
Modification date20200327
UniProtAcc

Q9BUB5


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKNK1

GO:0006468

protein phosphorylation

9155018

HgeneMKNK1

GO:0018105

peptidyl-serine phosphorylation

17130135

HgeneMKNK1

GO:0035556

intracellular signal transduction

9155018



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'MKNK1[title] AND translation [title] AND human.'
GeneTitlePMID
MKNK1FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression31894299


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000003719464702590547025949Frame-shift
ENST000003719464702832047028515In-frame
ENST000003719464703708847037211In-frame
ENST000003719464704061847040692Frame-shift
ENST000003719464704620147046299Frame-shift

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST00000371946470283204702851527369331127465256321
ENST0000037194647037088470372112736658780465164205

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
Q9BUB52563211465ChainID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
Q9BUB51642051465ChainID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
Q9BUB525632149374DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9BUB516420549374DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q9BUB5164205165205Alternative sequenceID=VSP_007352;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15350534,ECO:0000303|PubMed:9155018;Dbxref=PMID:15350534,PMID:9155018
Q9BUB5256321308308Natural variantID=VAR_040803;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55791614,PMID:17344846
Q9BUB5256321271274Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW6
Q9BUB5256321277296HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW6


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Expression


check buttonGene expression level across TCGA pancancer
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check buttonGene expression level across GTEx pantissue
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check buttonExpression level of gene isoforms across TCGA pancancer
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check buttonExpression level of gene isoforms across GTEx pantissue
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check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
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check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LUSCMKNK1-1.77240583159110.000119179323433261
LUADMKNK1-1.648813350540250.000184346986492713
KIRPMKNK1-1.835506481513090.00608485564589501
KIRCMKNK1-1.361554318286844.53899662243056e-11


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue
DLBCMKNK1hsa-miR-497-5p99-0.3349907493061980.0218151554907431


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
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Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
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Cancer typeGeneCoefficientPvalue
PAADMKNK1-0.373638470.028366944

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MKNK1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
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Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
LGGCell metabolism geneMKNK1PLCB20.8235964243.87E-132
LGGIUPHARMKNK1PLCB20.8235964243.87E-132
THYMCell metabolism geneMKNK1PLCG10.8008746381.71E-28
THYMCell metabolism geneMKNK1DGKA0.8014166931.48E-28
THYMCell metabolism geneMKNK1PDE7A0.8046732826.07E-29
THYMCell metabolism geneMKNK1SLC23A10.8064210723.75E-29
THYMCell metabolism geneMKNK1EDEM10.8075586972.73E-29
THYMCell metabolism geneMKNK1PAFAH20.8159038092.49E-30
THYMCGCMKNK1PLCG10.8008746381.71E-28
THYMCGCMKNK1ITK0.8010673611.62E-28
THYMCGCMKNK1IKZF10.8295274343.81E-32
THYMCGCMKNK1MDM40.83160691.95E-32
THYMCGCMKNK1FNBP10.8378299072.47E-33
THYMEpifactorMKNK1GFI10.8056347824.66E-29
THYMEpifactorMKNK1IKZF10.8295274343.81E-32
THYMEpifactorMKNK1MSL30.8440804922.85E-34
THYMIUPHARMKNK1PLCG10.8008746381.71E-28
THYMIUPHARMKNK1ITK0.8010673611.62E-28
THYMIUPHARMKNK1PDE7A0.8046732826.07E-29
THYMIUPHARMKNK1SLC23A10.8064210723.75E-29
THYMIUPHARMKNK1PAFAH20.8159038092.49E-30
THYMIUPHARMKNK1LAIR10.8194153278.77E-31
THYMIUPHARMKNK1IRAK40.8232415442.74E-31
THYMIUPHARMKNK1CD40.8238975092.24E-31
THYMIUPHARMKNK1NLRC30.8348927546.62E-33
THYMIUPHARMKNK1SLC7A60.8546610945.85E-36
THYMIUPHARMKNK1CYP2U10.8575098171.95E-36
THYMKinaseMKNK1ITK0.8010673611.62E-28
THYMKinaseMKNK1IRAK40.8232415442.74E-31
THYMTFMKNK1GFI10.8056347824.66E-29
THYMTFMKNK1IKZF10.8295274343.81E-32
THYMTSGMKNK1CD40.8238975092.24E-31
THYMTSGMKNK1IKZF10.8295274343.81E-32
UCSCell metabolism geneMKNK1PLCG10.8008746381.71E-28
UCSCell metabolism geneMKNK1DGKA0.8014166931.48E-28
UCSCell metabolism geneMKNK1PDE7A0.8046732826.07E-29
UCSCell metabolism geneMKNK1SLC23A10.8064210723.75E-29
UCSCell metabolism geneMKNK1EDEM10.8075586972.73E-29
UCSCell metabolism geneMKNK1PAFAH20.8159038092.49E-30
UCSCGCMKNK1PLCG10.8008746381.71E-28
UCSCGCMKNK1ITK0.8010673611.62E-28
UCSCGCMKNK1IKZF10.8295274343.81E-32
UCSCGCMKNK1MDM40.83160691.95E-32
UCSCGCMKNK1FNBP10.8378299072.47E-33
UCSEpifactorMKNK1GFI10.8056347824.66E-29
UCSEpifactorMKNK1IKZF10.8295274343.81E-32
UCSEpifactorMKNK1MSL30.8440804922.85E-34
UCSIUPHARMKNK1PLCG10.8008746381.71E-28
UCSIUPHARMKNK1ITK0.8010673611.62E-28
UCSIUPHARMKNK1PDE7A0.8046732826.07E-29
UCSIUPHARMKNK1SLC23A10.8064210723.75E-29
UCSIUPHARMKNK1PAFAH20.8159038092.49E-30
UCSIUPHARMKNK1LAIR10.8194153278.77E-31
UCSIUPHARMKNK1IRAK40.8232415442.74E-31
UCSIUPHARMKNK1CD40.8238975092.24E-31
UCSIUPHARMKNK1NLRC30.8348927546.62E-33
UCSIUPHARMKNK1SLC7A60.8546610945.85E-36
UCSIUPHARMKNK1CYP2U10.8575098171.95E-36
UCSKinaseMKNK1ITK0.8010673611.62E-28
UCSKinaseMKNK1IRAK40.8232415442.74E-31
UCSTFMKNK1GFI10.8056347824.66E-29
UCSTFMKNK1IKZF10.8295274343.81E-32
UCSTSGMKNK1CD40.8238975092.24E-31
UCSTSGMKNK1IKZF10.8295274343.81E-32


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
KICHMKNK1MAPK11.273190025953580.000911891460418701
BRCAMKNK1MAPK3-1.619099761392630.00193136402459222
KIRCMKNK1SPRY2-2.596972673504690.00224635330560483
CHOLMKNK1MAPK3-1.540681934246760.00390625
ESCAMKNK1PLA2G4A2.728696997798120.0048828125
KICHMKNK1EIF4G1-1.466560811507430.00612920522689819
LUADMKNK1PPP2CA-2.592794556805570.00847843979516537
KICHMKNK1PLA2G4A-3.729275917912150.0135546922683716
ESCAMKNK1MAPK1-1.177554743240530.0185546875
KIRCMKNK1PPP2CA-1.270463068224350.0253347545755805
ESCAMKNK1EIF4A1-1.245380731992850.0419921875
ESCAMKNK1SPRY22.516188351283840.0419921875
BRCAMKNK1MAPK1-1.679548752191510.0427276834041307
THCAMKNK1PLA2G4A1.746124005075971.06211531258311e-06
BRCAMKNK1MAPK14-1.69281314807611.08867679255958e-06
PRADMKNK1PLA2G4A-2.477492882991881.18254481038506e-06
PRADMKNK1MAPK141.202738509659862.06740855708439e-05
LIHCMKNK1MAPK11-2.042441774103992.35319665208461e-06
LUADMKNK1SPRY2-2.776696886394224.00021479245452e-09
COADMKNK1MAPK3-1.171732831463525.66244125366212e-07
KICHMKNK1EIF4E1.616752105626716.55651092529297e-06
LUADMKNK1PLA2G4A1.74098500046227.52266307692291e-07
KICHMKNK1EIF4A11.144855833095718.16583633422851e-06
THCAMKNK1MAPK11-4.044786162869938.27580425414032e-05


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MKNK1
FANCA, MAPK1, EIF4E, EIF4G1, EIF4G2, MAPK3, MAPK14, CREBBP, HSP90AB1, PRKDC, DNAJC7, EIF4G3, DDAH2, ATXN3, UBE2D1, PHAX, SPRY2, APP, RCN3, TNIP2, HGS, HIPK2, MAPK11, MOV10, XPO1, ID1, LLGL2, PDK1, PPIA, RAB5A, MYH13, KIF1C, RNASEH2B, KIF18A, PARD6B, BOD1L1, Flot1, Nek2, Itsn2, Cul1, Mkln1, Pdlim5, Chmp4c, Sept7, Wiz, Dennd6a, Rhoa, PAK2, TRIM25, EGLN3, CREM, CCL16, BPIFA1, AHNAK2, TNFRSF1B, AMOTL2, ABHD10,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MKNK1LIHCchr14702836547028365CTMissense_Mutationp.A307T3
MKNK1SKCMchr14704229947042299GAMissense_Mutationp.R88W3
MKNK1BLCAchr14702433047024330GAMissense_Mutationp.P439S3
MKNK1ESCAchr14702717647027176CTMissense_Mutationp.V368I3
MKNK1LIHCchr14702836547028365CTMissense_Mutation3
MKNK1HNSCchr14704628147046281GAMissense_Mutationp.S52F3
MKNK1UCECchr14702721447027214AGMissense_Mutationp.L355P3
MKNK1ACCchr14702836247028362CTMissense_Mutationp.D308N2
MKNK1UCECchr14702594647025946CTMissense_Mutationp.A378T2
MKNK1KIRCchr14702850847028508GCMissense_Mutationp.S259C2
MKNK1STADchr14702444147024441CTMissense_Mutationp.A402T2
MKNK1LIHCchr14703071447030714G-Splice_Sitep.P256_splice2
MKNK1UCECchr14704232147042321GAMissense_Mutationp.S10L2
MKNK1SKCMchr14704892047048920GAMissense_Mutationp.S39F2
MKNK1STADchr14702437047024370CAMissense_Mutationp.E425D2
MKNK1UCECchr14705983847059838ACRNANULL2
MKNK1CESCchr14705980647059806GCMissense_Mutation2
MKNK1STADchr14702723347027233CAMissense_Mutationp.D349Y2
MKNK1LUADchr14703077547030775CTMissense_Mutationp.G236S2
MKNK1CESCchr14705980647059806GCMissense_Mutationp.Q5E2
MKNK1LGGchr14702429947024299GAMissense_Mutation2
MKNK1LUADchr14702847647028476CAMissense_Mutationp.V270F2
MKNK1BLCAchr14702430747024307CTSilentp.R446R2
MKNK1ESCAchr14702717647027176CTMissense_Mutation2
MKNK1THYMchr14702835847028358CTMissense_Mutationp.C309Y2
MKNK1SKCMchr14702433547024335GAMissense_Mutationp.S437F2
MKNK1STADchr14702444147024441CTMissense_Mutation2
MKNK1BLCAchr14702594247025942GAMissense_Mutationp.P379L1
MKNK1OVchr14681322146813221CGMissense_Mutationp.E125Q1
MKNK1SKCMchr14703413447034134ACMissense_Mutationp.L177W1
MKNK1BLCAchr14702433047024330GAMissense_Mutation1
MKNK1BLCAchr14702436947024369C-Frame_Shift_Delp.A426fs1
MKNK1OVchr14705164747051647CCSplice_Sitee1-11
MKNK1LGGchr14702429947024299GAMissense_Mutationp.A408V1
MKNK1BLCAchr14702430747024307CTSilent1
MKNK1LIHCchr14702426847024268C-Frame_Shift_Delp.R459fs1
MKNK1PAADchr14703075847030758CASilent1
MKNK1LGGchr14702429947024299GAMissense_Mutationp.A449V1
MKNK1BLCAchr14702436947024369C-Frame_Shift_Del1
MKNK1PAADchr14702430847024308CTMissense_Mutation1
MKNK1STADchr14704627347046273GAMissense_Mutationp.L55F1
MKNK1LGGchr14702439947024399CTMissense_Mutationp.E416K1
MKNK1SKCMchr14703413447034134ACMissense_Mutationp.L218W1
MKNK1BLCAchr14702850347028503CTMissense_Mutation1
MKNK1LUADchr14703777847037778CGSilentp.V150V1
MKNK1COADchr14704228347042283CTMissense_Mutationp.R93Q1
MKNK1READchr14704620947046209GTMissense_Mutationp.A76D1
MKNK1STADchr14703077047030770AGSilentp.S237S1
MKNK1LGGchr14703079147030791GTSilentp.I230I1
MKNK1SKCMchr14704628347046283GASilentp.T51T1
MKNK1BLCAchr14702594247025942GAMissense_Mutation1
MKNK1LUADchr14702444147024441CGMissense_Mutationp.A402P1
MKNK1COADchr14704621247046212TCMissense_Mutationp.Y75C1
MKNK1SARCchr14703781347037813GTMissense_Mutation1
MKNK1THYMchr14704623847046238GASilent1
MKNK1SKCMchr14702727247027272GAMissense_Mutationp.P336S1
MKNK1SARCchr14705984947059849GTMissense_Mutation1
MKNK1LGGchr14703079147030791GTSilent1
MKNK1SKCMchr14704230647042306CTMissense_Mutationp.G15D1
MKNK1THYMchr14702835847028358CTMissense_Mutation1
MKNK1LUADchr14703773947037739GCSilentp.T163T1
MKNK1SARCchr14702846047028460GTMissense_Mutation1
MKNK1SKCMchr14702715847027158CTMissense_Mutationp.V374M1
MKNK1THYMchr14704623847046238GASilentp.A66A1
MKNK1BLCAchr14702429747024297GCMissense_Mutationp.L450V1
MKNK1LUADchr14704066447040664CTMissense_Mutationp.E115K1
MKNK1HNSCchr14704628147046281GAMissense_Mutation1
MKNK1SARCchr14703072447030724GTMissense_Mutation1
MKNK1LIHCchr14703775747037757GTSilent1
MKNK1BLCAchr14704064147040641CAMissense_Mutationp.L122F1
MKNK1OVchr14682152746821527CASilentp.R321
MKNK1SARCchr14705160647051606GASilentp.V251
MKNK1LIHCchr14704899347048993TGMissense_Mutationp.S15R1
MKNK1BLCAchr14702850347028503CTMissense_Mutationp.E261K1
MKNK1OVchr14680672246806722AGSilentp.L2181
MKNK1HNSCchr14702590847025908CTSilentp.Q390Q1
MKNK1SKCMchr14704230647042306CTSilentp.G85G1

check buttonCopy number variation (CNV) of MKNK1
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MKNK1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
60839LUADTCGA-55-8506-01AMKNK1chr147069857-ATPAF1chr147118300-
60839LUADTCGA-55-8506-01AMKNK1chr147069899-ATPAF1chr147118300-
60839OVTCGA-13-0893-01BMKNK1chr147082383-ATPAF1chr147131036-
60839OVTCGA-24-1428MKNK1chr147059784-ATPAF1chr147110928-
92208OVTCGA-13-0893-01BMKNK1chr147082383-EFCAB14chr147131036-
92208UCECTCGA-KP-A3W4-01AMKNK1chr147082383-EFCAB14chr147182115-
54098N/ABG898608MKNK1chr147023089-MKNK1-AS1chr147023171+
71598N/ABM151930PSD3chr818793632-MKNK1chr147063141+
71598SARCTCGA-DX-AB2O-01ARABIFchr1202858101-MKNK1chr147059952-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
SARCMKNK10.007610509409551130.21
LUADMKNK10.03776132839849481
LIHCMKNK10.04851924364262761

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
GBMMKNK10.03559768926975271
LGGMKNK10.02125395172825680.66
BRCAMKNK10.002647653878327640.085
THYMMKNK10.0001021387177090650.0034

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0029231Organic Mental Disorders, Substance-Induced1CTD_human
C0038580Substance Dependence1CTD_human
C0740858Substance abuse problem1CTD_human