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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF3D (NCBI Gene ID:8664)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF3D
	Gene ID: 8664
	Gene Symbol	EIF3D
	Gene ID	8664
	Gene Name	eukaryotic translation initiation factor 3 subunit D
	Synonyms	EIF3S7\|eIF3-p66\|eIF3-zeta
	Cytomap	22q12.3
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunit
	Modification date	20200313
	UniProtAcc	O15371

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF3D	GO:0002191	cap-dependent translational initiation	27462815
Hgene	EIF3D	GO:0006413	translational initiation	17581632
Hgene	EIF3D	GO:0075522	IRES-dependent viral translational initiation	9573242
Hgene	EIF3D	GO:0075525	viral translational termination-reinitiation	21347434

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF3D	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF3D[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF3D	A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress	33184215

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000216190	36908506	36908649	Frame-shift
ENST00000405442	36908506	36908649	Frame-shift
ENST00000216190	36913347	36913478	Frame-shift
ENST00000405442	36913347	36913478	Frame-shift
ENST00000216190	36916622	36916735	Frame-shift
ENST00000405442	36916622	36916735	Frame-shift
ENST00000216190	36919255	36919328	Frame-shift
ENST00000405442	36919255	36919328	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	EIF3D	-2.4724631441106	0.000299564272708473
KICH	EIF3D	-5.64942867023017	0.0202749371528625
KIRC	EIF3D	-2.33501876832058	1.16831478033445e-08
LIHC	EIF3D	-2.51854304632799	2.35319665208461e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF3D (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	EIF3D	NUP62	0.803492839	3.07E-11
CHOL	Cell metabolism gene	EIF3D	SNRPB	0.806114546	2.36E-11
CHOL	Cell metabolism gene	EIF3D	LCMT1	0.823203933	3.90E-12
CHOL	Cell metabolism gene	EIF3D	NOP56	0.825191477	3.13E-12
CHOL	CGC	EIF3D	TCF3	0.85165841	1.21E-13
CHOL	Epifactor	EIF3D	TAF6	0.819397002	5.92E-12
CHOL	Epifactor	EIF3D	EHMT2	0.839607079	5.72E-13
CHOL	Epifactor	EIF3D	TRIM28	0.844353199	3.16E-13
CHOL	Epifactor	EIF3D	PRMT1	0.850761615	1.37E-13
CHOL	Epifactor	EIF3D	HMGN4	0.851027724	1.32E-13
CHOL	IUPHAR	EIF3D	CSNK1E	0.815641492	8.86E-12
CHOL	IUPHAR	EIF3D	LPAR2	0.822970939	4.00E-12
CHOL	IUPHAR	EIF3D	ORAI2	0.831862007	1.45E-12
CHOL	IUPHAR	EIF3D	LIMK1	0.83843053	6.62E-13
CHOL	IUPHAR	EIF3D	EHMT2	0.839607079	5.72E-13
CHOL	IUPHAR	EIF3D	TRIM28	0.844353199	3.16E-13
CHOL	IUPHAR	EIF3D	PRMT1	0.850761615	1.37E-13
CHOL	Kinase	EIF3D	CSNK1E	0.815641492	8.86E-12
CHOL	Kinase	EIF3D	ABR	0.818713635	6.38E-12
CHOL	Kinase	EIF3D	LIMK1	0.83843053	6.62E-13
CHOL	Kinase	EIF3D	TRIM28	0.844353199	3.16E-13
CHOL	TF	EIF3D	ZBTB12	0.818037258	6.86E-12
CHOL	TF	EIF3D	ZNF581	0.825222159	3.11E-12
CHOL	TF	EIF3D	TCF3	0.85165841	1.21E-13
CHOL	TSG	EIF3D	GAS5	0.814959081	9.52E-12
CHOL	TSG	EIF3D	TCF3	0.85165841	1.21E-13
DLBC	Cell metabolism gene	EIF3D	GFER	0.805155714	5.25E-12
DLBC	TSG	EIF3D	GLTSCR2	0.807336375	4.16E-12
DLBC	TSG	EIF3D	GNB2L1	0.834224418	1.78E-13
LGG	TSG	EIF3D	GNB2L1	0.803031218	8.73E-121
PCPG	Cell metabolism gene	EIF3D	ADSL	0.869541572	1.39E-58
PRAD	TSG	EIF3D	GNB2L1	0.808804144	1.88E-128
TGCT	Cell metabolism gene	EIF3D	TOMM22	0.860896644	4.76E-47
TGCT	Cell metabolism gene	EIF3D	ADSL	0.888315734	6.48E-54
THYM	Cell metabolism gene	EIF3D	TOMM22	0.81057525	1.16E-29
UCS	Cell metabolism gene	EIF3D	TOMM22	0.81057525	1.16E-29
UVM	CGC	EIF3D	NACA	0.801244021	4.46E-19
UVM	TSG	EIF3D	GNB2L1	0.802736963	3.43E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	EIF3D	EIF3K	-1.81556046390697	0.000109195709228516
KICH	EIF3D	EIF3I	1.57310069220802	0.000139892101287842
LIHC	EIF3D	EIF3H	-1.90440880391985	0.000201991820198738
PRAD	EIF3D	EIF3A	1.13680328391952	0.000363360004697762
LIHC	EIF3D	EIF3C	-1.23074521883972	0.00126327311470459
KIRP	EIF3D	EIF3F	-2.66679834873128	0.00143672106787562
BRCA	EIF3D	EIF3I	-1.72233459275531	0.00191218761269043
KIRC	EIF3D	EIF3F	-1.2992747256102	0.00267981494905134
BLCA	EIF3D	EIF3F	-2.42045354534588	0.00457763671875
KIRP	EIF3D	EIF3G	-2.4178322962129	0.00471024587750435
THCA	EIF3D	EIF3H	-1.36389805160882	0.00492925389458784
BLCA	EIF3D	EIF3A	-4.45104058307747	0.00532913208007812
LIHC	EIF3D	EIF3E	-5.1722332599854	0.00593802028362182
UCEC	EIF3D	EIF3G	-3.35078334696571	0.03125
BLCA	EIF3D	EIF3G	-3.07707559649091	0.0323410034179688
LUAD	EIF3D	EIF3B	-5.80435587546762	1.0542655358657e-09
LUSC	EIF3D	EIF3H	-2.96137689554772	1.45608838900009e-05
BRCA	EIF3D	EIF3G	1.87948385011271	1.9107949115022e-06
KIRC	EIF3D	EIF3B	-1.56313263784517	2.35252849767166e-12
STAD	EIF3D	EIF3B	-4.7724660972007	3.25962901115418e-08
LUAD	EIF3D	EIF3M	-1.5429573968308	4.40678669801292e-06
HNSC	EIF3D	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	EIF3D	EIF3B	-2.7592297042974	4.6566128730774e-09
BRCA	EIF3D	EIF3A	-1.218215573148	7.39403582934137e-06
KIRC	EIF3D	EIF3E	-4.49824101219462	7.8509870430991e-09
KIRC	EIF3D	EIF3M	-2.00888134658998	8.07326657761222e-05
BRCA	EIF3D	EIF3E	-1.48408348062463	9.51829316317813e-08
KIRC	EIF3D	EIF3H	-1.0332219257812	9.65225899474882e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF3D

EIF1B, EIF4A2, EIF3A, EIF3L, PHLDA1, EIF3G, EIF3H, EIF3F, USP3, HAX1, CD4, Eif3a, EIF3E, PSMD12, DNAJB11, RAD21, SIRT7, CAND1, EIF3C, EIF3K, EIF3B, EIF3I, EIF3M, NCL, DDX3X, FN1, VCAM1, gag-pol, EIF3J, HNRNPU, RPL23A, RPL35, RPS11, RPS12, RPS18, RPS20, RPS27, RPS28, RPS4X, RPS9, STAU1, REL, TRIM27, SAT1, HOMER3, BEND5, LZTS2, CCDC8, RNF2, ABCE1, FBXW11, EIF3CL, SRSF7, SRSF5, SUPT4H1, NTRK1, HERC2, XPO1, MATR3, Eif3e, Eif3i, Rpl35, Sgol2, GAN, MCM2, BCOR, NANOG, POU5F1, ZNF746, EIF4A1, RAF1, CYLD, DLD, DNM1L, HSD17B10, SOD1, TRIM25, G3BP1, UBE2A, CHMP2A, DCAF7, EIF2B5, EIF3D, EXOSC9, MRPS5, MTOR, NCAPD2, PSMD4, PWP1, RPL23, YTHDC1, ZNF598, KRAS, YAP1, UBE2M, PYHIN1, EFTUD2, CHD4, ESR2, HEXIM1, MEPCE, LARP7, RNF123, RECQL4, MYC, KIAA1429, EIF4B, ATG16L1, CREBBP, NR2C2, PRDM16, MECOM, CD74, DDX60, ITFG1, BIRC3, NFX1, WWP2, TRIM28, ZRANB1, HOOK2, TFIP11, PICK1, TRIM23, CEP70, MTUS2, MORN3, KIFC3, HSF2BP, DVL3, POLR2G, CCDC57, CCDC125, GOLGA6L9, ANKRD28, PLEKHA4, KCTD10, CUL3, HSPA5, ZC3H18, CFL1, nsp1, ESR1, ERCC6, KIF14, NGEF, DOCK6, MKI67, nsp2ab, CDC42, NDN, BRD4, NUPR1, CIC, Apc2, RBM39, USP10, EIF4E, EIF4G3, EIF4EBP2, EIF4ENIF1, EIF4EBP1, EIF4G1, ANGEL1, OGT, UFL1, DDRGK1, POLR2C, FZR1, WDR5, NUDCD2, NAA40, PRRC2B, GATAD2B, MTA1, TUSC1, MTA3, MBD3, ADNP, BTF3, EP300, FBXW7, SLFN11, KLF16, RB1CC1, KLF8,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF3D	chr22	36914967	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF3D	chr22	36915445	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF3D	chr22	36915464	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
EIF3D	chr22	36921761	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF3D	SKCM	chr22	36922104	36922104	G	A	Missense_Mutation	p.P22L	4
EIF3D	PAAD	chr22	36912757	36912757	C	T	Silent	p.A357A	3
EIF3D	UCS	chr22	36919950	36919950	C	T	Silent	p.Q128Q	3
EIF3D	SKCM	chr22	36916708	36916708	G	A	Missense_Mutation	p.R165C	3
EIF3D	PAAD	chr22	36915498	36915498	C	T	Missense_Mutation	p.R222H	3
EIF3D	BRCA	chr22	36907562	36907562	C	G	Missense_Mutation	p.E541Q	2
EIF3D	LIHC	chr22	36920731	36920731	T	C	Missense_Mutation		2
EIF3D	PAAD	chr22	36915498	36915498	C	T	Missense_Mutation		2
EIF3D	SKCM	chr22	36922128	36922128	G	A	Missense_Mutation	p.S14L	2
EIF3D	ESCA	chr22	36920691	36920691	C	T	Silent	p.A86A	2
EIF3D	BRCA	chr22	36907704	36907704	G	A	Silent	p.C493	2
EIF3D	LIHC	chr22	36919311	36919311	T	A	Missense_Mutation		2
EIF3D	CESC	chr22	36915583	36915583	C	G	Missense_Mutation		2
EIF3D	LIHC	chr22	36920644	36920644	T	A	Missense_Mutation		2
EIF3D	BLCA	chr22	36922179	36922179	C	G	Splice_Site		2
EIF3D	CESC	chr22	36907574	36907574	C	G	Missense_Mutation		2
EIF3D	LIHC	chr22	36920731	36920731	T	C	Missense_Mutation	p.H73R	2
EIF3D	PRAD	chr22	36907719	36907719	C	A	Missense_Mutation	p.W488C	2
EIF3D	CESC	chr22	36913354	36913354	C	G	Missense_Mutation		2
EIF3D	LIHC	chr22	36919311	36919311	T	A	Missense_Mutation	p.Q137L	2
EIF3D	LUAD	chr22	36921726	36921726	C	T	Missense_Mutation	p.D52N	2
EIF3D	HNSC	chr22	36912642	36912642	C	T	Nonsense_Mutation	p.W363*	2
EIF3D	CESC	chr22	36915544	36915544	C	T	Missense_Mutation		2
EIF3D	SARC	chr22	36916653	36916653	C	T	Missense_Mutation		2
EIF3D	STAD	chr22	36919957	36919957	G	A	Missense_Mutation	p.A126V	2
EIF3D	HNSC	chr22	36916654	36916654	G	A	Missense_Mutation	p.R183C	2
EIF3D	UCEC	chr22	36907688	36907688	T	C	Missense_Mutation	p.M499V	2
EIF3D	STAD	chr22	36912576	36912576	G	A	Silent	p.N385N	2
EIF3D	LUAD	chr22	36915565	36915565	C	T	Missense_Mutation	p.E200K	2
EIF3D	UCEC	chr22	36914916	36914916	G	A	Silent	p.I251	2
EIF3D	LIHC	chr22	36919305	36919305	T	-	Frame_Shift_Del	p.K139fs	2
EIF3D	SKCM	chr22	36912528	36912528	G	A	Silent	p.S401S	2
EIF3D	UCEC	chr22	36916626	36916626	T	C	Missense_Mutation	p.D192G	2
EIF3D	LIHC	chr22	36920760	36920760	A	-	Frame_Shift_Del	p.F63fs	2
EIF3D	SKCM	chr22	36913424	36913424	G	A	Missense_Mutation	p.S305F	2
EIF3D	ESCA	chr22	36919267	36919267	G	T	Missense_Mutation	p.Q152K	2
EIF3D	UCEC	chr22	36919229	36919229	G	T	Silent	p.A164	2
EIF3D	ESCA	chr22	36919267	36919267	G	T	Missense_Mutation		2
EIF3D	PAAD	chr22	36912757	36912757	C	T	Silent		2
EIF3D	UCEC	chr22	36922110	36922110	G	A	Missense_Mutation	p.A20V	2
EIF3D	SKCM	chr22	36908515	36908515	G	A	Silent	p.L447L	2
EIF3D	ESCA	chr22	36920691	36920691	C	T	Silent		2
EIF3D	UCS	chr22	36919950	36919950	C	T	Silent		1
EIF3D	CESC	chr22	36913354	36913354	C	G	Missense_Mutation	p.L328F	1
EIF3D	LIHC	chr22	36907717	36907717	C	-	Frame_Shift_Del	p.G489fs	1
EIF3D	THYM	chr22	36920749	36920749	C	T	Missense_Mutation		1
EIF3D	BLCA	chr22	36914924	36914924	C	T	Missense_Mutation		1
EIF3D	COAD	chr22	36907814	36907814	C	T	Missense_Mutation	p.V457M	1
EIF3D	LIHC	chr22	36913442	36913442	G	-	Frame_Shift_Del	p.P299fs	1
EIF3D	THYM	chr22	36920749	36920749	C	T	Missense_Mutation	p.S67N	1
EIF3D	BLCA	chr22	36920006	36920006	C	G	Missense_Mutation		1
EIF3D	ESCA	chr22	36915511	36915511	G	T	Silent	p.R218R	1
EIF3D	SKCM	chr22	36922108	36922108	C	T	Missense_Mutation	p.V21I	1
EIF3D	COAD	chr22	36912817	36912817	G	A	Silent	p.F337F	1
EIF3D	LUAD	chr22	36912774	36912774	C	T	Missense_Mutation	p.E352K	1
EIF3D	THYM	chr22	36922119	36922119	C	T	Missense_Mutation	p.G17D	1
EIF3D	HNSC	chr22	36922051	36922051	C	T	Missense_Mutation		1
EIF3D	SKCM	chr22	36908591	36908591	G	A	Missense_Mutation	p.A422V	1
EIF3D	COAD	chr22	36913410	36913410	G	A	Missense_Mutation	p.R310C	1
EIF3D	UCEC	chr22	36915511	36915511	G	A	Missense_Mutation	p.R218W	1
EIF3D	BLCA	chr22	36912865	36912865	G	T	Missense_Mutation		1
EIF3D	HNSC	chr22	36912630	36912630	A	G	Silent		1
EIF3D	SARC	chr22	36913454	36913454	G	A	Missense_Mutation		1
EIF3D	STAD	chr22	36919957	36919957	G	A	Missense_Mutation		1
EIF3D	COAD	chr22	36920660	36920660	G	A	Nonsense_Mutation	p.R97X	1
EIF3D	UCEC	chr22	36914916	36914916	G	A	Silent	p.I251I	1
EIF3D	BLCA	chr22	36920720	36920720	C	T	Missense_Mutation	p.E77K	1
EIF3D	LIHC	chr22	36920644	36920644	T	A	Missense_Mutation	p.Q102L	1
EIF3D	BLCA	chr22	36920720	36920720	C	T	Missense_Mutation		1
EIF3D	COAD	chr22	36922148	36922148	G	A	Silent	p.P7P	1
EIF3D	BLCA	chr22	36908628	36908628	G	A	Missense_Mutation	p.R410C	1
EIF3D	LUAD	chr22	36912753	36912753	G	A	Splice_Site	p.R359_splice	1
EIF3D	CESC	chr22	36915583	36915583	C	G	Splice_Site	p.E194_splice	1
EIF3D	LIHC	chr22	36920644	36920644	T	A	Splice_Site	p.Q102_splice	1
EIF3D	SARC	chr22	36916653	36916653	C	T	Missense_Mutation	p.R183H	1
EIF3D	BLCA	chr22	36908628	36908628	G	A	Missense_Mutation		1
EIF3D	COAD	chr22	36907710	36907710	T	C	Silent	p.L491L	1
EIF3D	BLCA	chr22	36919946	36919946	C	T	Missense_Mutation	p.E130K	1
EIF3D	LGG	chr22	36907606	36907606	G	A	Missense_Mutation	p.T526I	1
EIF3D	CESC	chr22	36907574	36907574	C	G	Missense_Mutation	p.E537Q	1
EIF3D	THCA	chr22	36920659	36920659	C	T	Missense_Mutation		1
EIF3D	BLCA	chr22	36919238	36919238	C	G	Missense_Mutation		1
EIF3D	DLBC	chr22	36907798	36907798	C	T	Missense_Mutation	p.R462H	1
EIF3D	BLCA	chr22	36914924	36914924	C	T	Missense_Mutation	p.D249N	1
EIF3D	LIHC	chr22	36914944	36914944	T	C	Missense_Mutation		1
EIF3D	LUAD	chr22	36912753	36912753	G	A	Missense_Mutation	p.R359C	1
EIF3D	CESC	chr22	36912933	36912933	G	A	RNA	NULL	1
EIF3D	THCA	chr22	36912753	36912753	G	T	Missense_Mutation		1
EIF3D	BLCA	chr22	36919946	36919946	C	T	Missense_Mutation		1
EIF3D	BLCA	chr22	36913461	36913461	C	A	Nonsense_Mutation	p.E293*	1
EIF3D	LIHC	chr22	36913346	36913346	A	G	Splice_Site		1
EIF3D	LUSC	chr22	36907704	36907704	G	A	Silent	p.C493C	1
EIF3D	CESC	chr22	36915544	36915544	C	T	Missense_Mutation	p.D207N	1
EIF3D	LIHC	chr22	36908586	36908586	C	-	Frame_Shift_Del	p.E424fs	1
EIF3D	THCA	chr22	36912575	36912575	C	A	Missense_Mutation		1
EIF3D	BLCA	chr22	36919296	36919296	T	C	Missense_Mutation		1
EIF3D	BLCA	chr22	36920006	36920006	C	G	Missense_Mutation	p.D110H	1
EIF3D	LIHC	chr22	36916716	36916716	A	G	Missense_Mutation		1
EIF3D	CESC	chr22	36915583	36915583	C	G	Missense_Mutation	p.E194Q	1
EIF3D	LIHC	chr22	36919947	36919947	T	-	Frame_Shift_Del	p.K129fs	1
EIF3D	THCA	chr22	36920659	36920659	C	T	Missense_Mutation	p.R97Q	1
EIF3D	BLCA	chr22	36907835	36907835	T	A	Splice_Site		1

Copy number variation (CNV) of EIF3D
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF3D
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
89814	ESCA	TCGA-LN-A7HZ	CLTCL1	chr22	19175069	-	EIF3D	chr22	36922178	-
89814	N/A	AA463841	EIF3D	chr22	36906993	-	EIF3D	chr22	36907809	-
89814	N/A	AI028447	EIF3D	chr22	36907656	+	EIF3D	chr22	36912638	-
89814	N/A	CD688331	EIF3D	chr22	36907748	-	EIF3D	chr22	36922081	-
82680	N/A	BG991794	EIF3D	chr22	36922128	+	FAM111A	chr11	58919481	-
98113	SKCM	TCGA-ER-A19H-06A	EIF3D	chr22	36906902	-	IQCE	chr7	2641075	+
99664	N/A	AA167318	EIF3D	chr22	36907049	+	MLLT10	chr10	22006516	+
103282	LUSC	TCGA-85-7696	EIF3D	chr22	36925122	-	MYH9	chr22	36682892	-
103282	LUSC	TCGA-85-7696-01A	EIF3D	chr22	36925123	-	MYH9	chr22	36682892	-
101382	OV	TCGA-13-1495	EIF3D	chr22	36914809	-	NDUFB2	chr7	140406362	+
93513	LUAD	TCGA-78-7153-01A	EIF3D	chr22	36906902	-	PLEKHB2	chr2	131876464	+
93620	N/A	BF768948	EIF3D	chr22	36916733	+	PSMD13	chr11	252820	+
77262	N/A	BE122809	EIF3D	chr22	36908615	-	S100A2	chr1	153536246	-
92843	N/A	BM974825	EIF3D	chr22	36907007	+	TNRC18	chr7	5347525	+
39538	READ	TCGA-AG-A008	EIF3D	chr22	36906996	-	TYRO3	chr15	41854865	+
96590	N/A	BE260321	EIF3D	chr22	36920681	-	UCP2	chr11	73693808	-
89814	STAD	TCGA-D7-5577-01A	MON1A	chr3	49967042	-	EIF3D	chr22	36922178	-
89814	BRCA	TCGA-AN-A0FJ	MYH9	chr22	36737414	-	EIF3D	chr22	36907833	-
89814	BRCA	TCGA-AN-A0FJ-01A	MYH9	chr22	36737415	-	EIF3D	chr22	36907833	-
89814	LIHC	TCGA-EP-A2KA-01A	MYH9	chr22	36783852	-	EIF3D	chr22	36915584	-
89814	STAD	TCGA-BR-8382	NDRG3	chr20	35312815	-	EIF3D	chr22	36907833	-
89814	BRCA	TCGA-V7-A7HQ-01A	NF2	chr22	30000101	+	EIF3D	chr22	36908649	-
89814	N/A	BM910722	PEG10	chr7	94298837	-	EIF3D	chr22	36925196	-
89814	OV	TCGA-25-2396	RAPGEF1	chr9	134525515	-	EIF3D	chr22	36907047	-
89814	N/A	EC580829	RPS4Y1	chrY	2753051	-	EIF3D	chr22	36906903	+
89814	N/A	BE122841	S100A2	chr1	153536246	+	EIF3D	chr22	36908615	+
89814	ACC	TCGA-OR-A5JY-01A	SCARB1	chr12	125262179	-	EIF3D	chr22	36922952	-
89814	BRCA	TCGA-BH-A0DZ	SGSH	chr17	78187970	-	EIF3D	chr22	36912837	-
89814	LGG	TCGA-CS-5397-01A	SMOX	chr20	4129624	+	EIF3D	chr22	36922178	-
89825	OV	TCGA-61-1918-01A	TCF7L2	chr10	114799885	+	EIF3D	chr22	36922178	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	EIF3D	0.00365813588034611	0.099
BRCA	EIF3D	0.0164492716674867	0.43
KIRC	EIF3D	2.35218206592483e-09	6.6e-08

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	EIF3D	0.0179210918508259	0.56
PAAD	EIF3D	0.0179394504429612	0.56
SARC	EIF3D	0.0153025660684725	0.49
MESO	EIF3D	0.0282191386949842	0.82
READ	EIF3D	0.00813344582701132	0.27

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source