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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF3I (NCBI Gene ID:8668)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF3I
	Gene ID: 8668
	Gene Symbol	EIF3I
	Gene ID	8668
	Gene Name	eukaryotic translation initiation factor 3 subunit I
	Synonyms	EIF3S2\|PRO2242\|TRIP-1\|TRIP1\|eIF3-beta\|eIF3-p36
	Cytomap	1p35.2
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 3 subunit ITGF-beta receptor-interacting protein 1TGFbeta receptor-interacting protein 1eukaryotic translation initiation factor 3 subunit 2eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)euk
	Modification date	20200313
	UniProtAcc	Q13347

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF3I	GO:0006413	translational initiation	17581632

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF3I	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF3I[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF3I	Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis	32061967

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000373586	32688138	32688231	In-frame
ENST00000373586	32691771	32691921	In-frame
ENST00000373586	32692003	32692131	Frame-shift
ENST00000373586	32694327	32694417	In-frame
ENST00000373586	32694735	32694809	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000373586	32688138	32688231	1475	76	168	325	1	32
ENST00000373586	32691771	32691921	1475	323	472	325	83	133
ENST00000373586	32694327	32694417	1475	712	801	325	213	243

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q13347	213	243	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
Q13347	1	32	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
Q13347	83	133	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
Q13347	1	32	1	39	Repeat	Note=WD 1
Q13347	83	133	87	127	Repeat	Note=WD 3
Q13347	213	243	180	217	Repeat	Note=WD 5
Q13347	213	243	221	267	Repeat	Note=WD 6
Q13347	213	243	219	219	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	EIF3I	1.57310069220802	0.000139892101287842
BRCA	EIF3I	-1.72233459275531	0.00191218761269043

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRP	EIF3I	0.037063005	0.049358338

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF3I (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	EIF3I	SNRPB	0.830417075	2.88E-13
GBM	Cell metabolism gene	EIF3I	SNRPG	0.811433231	1.67E-41
GBM	Cell metabolism gene	EIF3I	AK2	0.816101574	2.45E-42
GBM	Cell metabolism gene	EIF3I	PSMA7	0.819653536	5.49E-43
GBM	Cell metabolism gene	EIF3I	PSMA5	0.831971393	2.35E-45
GBM	Cell metabolism gene	EIF3I	PSMB4	0.842125096	1.86E-47
KICH	Cell metabolism gene	EIF3I	SNRPG	0.810614786	2.14E-22
KICH	Cell metabolism gene	EIF3I	PSMA5	0.812756944	1.35E-22
KICH	Cell metabolism gene	EIF3I	SSR2	0.844972702	6.41E-26
KICH	Cell metabolism gene	EIF3I	PSMB3	0.85870525	1.42E-27
KICH	Epifactor	EIF3I	TAF12	0.806428348	5.13E-22
KICH	IUPHAR	EIF3I	CSNK2B	0.84505869	6.27E-26
KICH	TSG	EIF3I	PARK7	0.848806314	2.30E-26
LGG	Cell metabolism gene	EIF3I	GNG5	0.803956468	2.88E-121
LGG	Cell metabolism gene	EIF3I	SRM	0.817710485	9.62E-129
LGG	Cell metabolism gene	EIF3I	AK2	0.827277144	2.51E-134
LGG	Cell metabolism gene	EIF3I	PSMB2	0.836772002	3.21E-140
LGG	Cell metabolism gene	EIF3I	TXNDC12	0.840060224	2.38E-142
LGG	Cell metabolism gene	EIF3I	PSMA5	0.876109989	1.99E-169
LGG	IUPHAR	EIF3I	PSMB2	0.836772002	3.21E-140
LGG	TSG	EIF3I	TTC4	0.822292087	2.24E-131
MESO	Cell metabolism gene	EIF3I	AK2	0.814945717	7.66E-22
PCPG	Cell metabolism gene	EIF3I	AK2	0.875403768	2.63E-60
PCPG	TSG	EIF3I	PARK7	0.803524403	1.53E-43
PRAD	Cell metabolism gene	EIF3I	NME1	0.802126295	8.38E-125
PRAD	TSG	EIF3I	NME1	0.802126295	8.38E-125
READ	Cell metabolism gene	EIF3I	PSMB2	0.805774773	3.56E-25
READ	IUPHAR	EIF3I	PSMB2	0.805774773	3.56E-25
TGCT	Cell metabolism gene	EIF3I	PSMB2	0.809453952	1.95E-37
TGCT	IUPHAR	EIF3I	PSMB2	0.809453952	1.95E-37
THCA	Cell metabolism gene	EIF3I	PSMB4	0.800017642	1.43E-128
THCA	IUPHAR	EIF3I	CSNK2B	0.818423567	2.85E-139
THYM	Cell metabolism gene	EIF3I	POLR2I	0.804672858	6.08E-29
THYM	Cell metabolism gene	EIF3I	PGLS	0.808646847	2.01E-29
THYM	Cell metabolism gene	EIF3I	LSM2	0.810948508	1.05E-29
THYM	Cell metabolism gene	EIF3I	PSMB1	0.81623166	2.26E-30
THYM	Cell metabolism gene	EIF3I	PSMB3	0.816465971	2.11E-30
THYM	Cell metabolism gene	EIF3I	TIMM50	0.820353645	6.61E-31
THYM	Cell metabolism gene	EIF3I	PSMD13	0.820972693	5.48E-31
THYM	Cell metabolism gene	EIF3I	TIMM8B	0.822011119	3.99E-31
THYM	Cell metabolism gene	EIF3I	APRT	0.822744817	3.19E-31
THYM	Cell metabolism gene	EIF3I	TIMM13	0.823363113	2.64E-31
THYM	Cell metabolism gene	EIF3I	FAU	0.830847743	2.49E-32
THYM	Cell metabolism gene	EIF3I	PSMB7	0.831029365	2.35E-32
THYM	Cell metabolism gene	EIF3I	UROD	0.83441692	7.75E-33
THYM	Cell metabolism gene	EIF3I	SNRPD3	0.840449071	1.01E-33
THYM	Cell metabolism gene	EIF3I	SNRPD2	0.844884314	2.14E-34
THYM	Cell metabolism gene	EIF3I	PSMC3	0.873911106	2.11E-39
THYM	CGC	EIF3I	TFPT	0.807640676	2.67E-29
THYM	Epifactor	EIF3I	ZNHIT1	0.802184953	1.20E-28
THYM	Epifactor	EIF3I	C17orf49	0.803696711	7.94E-29
THYM	Epifactor	EIF3I	TFPT	0.807640676	2.67E-29
THYM	Epifactor	EIF3I	BRMS1	0.808754051	1.95E-29
THYM	Epifactor	EIF3I	NOC2L	0.810152567	1.31E-29
THYM	Epifactor	EIF3I	SIRT6	0.813064612	5.70E-30
THYM	Epifactor	EIF3I	FBL	0.826802829	9.04E-32
THYM	Epifactor	EIF3I	RUVBL2	0.831445056	2.05E-32
THYM	Epifactor	EIF3I	TAF10	0.835210514	5.96E-33
THYM	Epifactor	EIF3I	PRPF31	0.851283977	2.09E-35
THYM	IUPHAR	EIF3I	SIRT6	0.813064612	5.70E-30
THYM	IUPHAR	EIF3I	PSMB1	0.81623166	2.26E-30
THYM	IUPHAR	EIF3I	PPIA	0.826669151	9.43E-32
THYM	TF	EIF3I	DRAP1	0.813115103	5.62E-30
THYM	TF	EIF3I	ZNF428	0.845715717	1.59E-34
THYM	TSG	EIF3I	BRMS1	0.808754051	1.95E-29
THYM	TSG	EIF3I	SIRT6	0.813064612	5.70E-30
THYM	TSG	EIF3I	GNB2L1	0.848207125	6.48E-35
THYM	TSG	EIF3I	PARK7	0.86875867	1.99E-38
UCS	Cell metabolism gene	EIF3I	POLR2I	0.804672858	6.08E-29
UCS	Cell metabolism gene	EIF3I	PGLS	0.808646847	2.01E-29
UCS	Cell metabolism gene	EIF3I	LSM2	0.810948508	1.05E-29
UCS	Cell metabolism gene	EIF3I	PSMB1	0.81623166	2.26E-30
UCS	Cell metabolism gene	EIF3I	PSMB3	0.816465971	2.11E-30
UCS	Cell metabolism gene	EIF3I	TIMM50	0.820353645	6.61E-31
UCS	Cell metabolism gene	EIF3I	PSMD13	0.820972693	5.48E-31
UCS	Cell metabolism gene	EIF3I	TIMM8B	0.822011119	3.99E-31
UCS	Cell metabolism gene	EIF3I	APRT	0.822744817	3.19E-31
UCS	Cell metabolism gene	EIF3I	TIMM13	0.823363113	2.64E-31
UCS	Cell metabolism gene	EIF3I	FAU	0.830847743	2.49E-32
UCS	Cell metabolism gene	EIF3I	PSMB7	0.831029365	2.35E-32
UCS	Cell metabolism gene	EIF3I	UROD	0.83441692	7.75E-33
UCS	Cell metabolism gene	EIF3I	SNRPD3	0.840449071	1.01E-33
UCS	Cell metabolism gene	EIF3I	SNRPD2	0.844884314	2.14E-34
UCS	Cell metabolism gene	EIF3I	PSMC3	0.873911106	2.11E-39
UCS	CGC	EIF3I	TFPT	0.807640676	2.67E-29
UCS	Epifactor	EIF3I	ZNHIT1	0.802184953	1.20E-28
UCS	Epifactor	EIF3I	C17orf49	0.803696711	7.94E-29
UCS	Epifactor	EIF3I	TFPT	0.807640676	2.67E-29
UCS	Epifactor	EIF3I	BRMS1	0.808754051	1.95E-29
UCS	Epifactor	EIF3I	NOC2L	0.810152567	1.31E-29
UCS	Epifactor	EIF3I	SIRT6	0.813064612	5.70E-30
UCS	Epifactor	EIF3I	FBL	0.826802829	9.04E-32
UCS	Epifactor	EIF3I	RUVBL2	0.831445056	2.05E-32
UCS	Epifactor	EIF3I	TAF10	0.835210514	5.96E-33
UCS	Epifactor	EIF3I	PRPF31	0.851283977	2.09E-35
UCS	IUPHAR	EIF3I	SIRT6	0.813064612	5.70E-30
UCS	IUPHAR	EIF3I	PSMB1	0.81623166	2.26E-30
UCS	IUPHAR	EIF3I	PPIA	0.826669151	9.43E-32
UCS	TF	EIF3I	DRAP1	0.813115103	5.62E-30
UCS	TF	EIF3I	ZNF428	0.845715717	1.59E-34
UCS	TSG	EIF3I	BRMS1	0.808754051	1.95E-29
UCS	TSG	EIF3I	SIRT6	0.813064612	5.70E-30
UCS	TSG	EIF3I	GNB2L1	0.848207125	6.48E-35
UCS	TSG	EIF3I	PARK7	0.86875867	1.99E-38
UVM	TSG	EIF3I	PARK7	0.836216103	4.78E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	EIF3I	RPSA	-2.66181804625988	0.00010013220697745
COAD	EIF3I	EIF3K	-1.81556046390697	0.000109195709228516
LUAD	EIF3I	EIF3D	-2.4724631441106	0.000299564272708473
PRAD	EIF3I	EIF3A	1.13680328391952	0.000363360004697762
LIHC	EIF3I	EIF3C	-1.23074521883972	0.00126327311470459
LUAD	EIF3I	EIF3J	-1.1109238877878	0.00216965225011196
KIRP	EIF3I	EIF3G	-2.4178322962129	0.00471024587750435
BLCA	EIF3I	EIF3A	-4.45104058307747	0.00532913208007812
LIHC	EIF3I	EIF3E	-5.1722332599854	0.00593802028362182
CHOL	EIF3I	RPSA	-1.88501253711962	0.0078125
KICH	EIF3I	EIF3D	-5.64942867023017	0.0202749371528625
UCEC	EIF3I	EIF3G	-3.35078334696571	0.03125
BLCA	EIF3I	EIF3G	-3.07707559649091	0.0323410034179688
PRAD	EIF3I	RPSA	1.15183588990872	0.0476188245531179
LUAD	EIF3I	EIF3B	-5.80435587546762	1.0542655358657e-09
KIRC	EIF3I	EIF3D	-2.33501876832058	1.16831478033445e-08
THCA	EIF3I	EIF3J	1.32428508175103	1.19078203681914e-07
THCA	EIF3I	RPS2	-2.9749691422722	1.8399565126656e-05
BRCA	EIF3I	EIF3G	1.87948385011271	1.9107949115022e-06
KIRC	EIF3I	RPS2	-3.31623058345719	2.17100738110179e-12
KIRC	EIF3I	EIF3B	-1.56313263784517	2.35252849767166e-12
LIHC	EIF3I	EIF3D	-2.51854304632799	2.35319665208461e-06
KICH	EIF3I	EIF3J	2.09716749126717	3.19480895996094e-05
STAD	EIF3I	EIF3B	-4.7724660972007	3.25962901115418e-08
HNSC	EIF3I	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	EIF3I	EIF3B	-2.7592297042974	4.6566128730774e-09
KIRP	EIF3I	RPS2	-2.72788021566791	5.12227416038514e-08
LUAD	EIF3I	RPS2	-2.88992098496468	6.51132046672323e-08
BRCA	EIF3I	EIF3A	-1.218215573148	7.39403582934137e-06
KIRC	EIF3I	EIF3E	-4.49824101219462	7.8509870430991e-09
KICH	EIF3I	RPS2	-4.73426315307469	8.34465026855468e-07
BRCA	EIF3I	EIF3E	-1.48408348062463	9.51829316317813e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF3I

EIF3A, EIF1B, LYAR, EIF4G1, EIF3B, EIF3H, EIF3F, USP3, SRRM2, TADA2A, MYC, CD4, Itsn2, Eif3a, CLEC4G, RAD21, ARRB1, SIRT7, CUL3, CDK2, EIF3E, EIF3G, EIF3C, EIF3D, EIF3K, EIF3M, EIF3L, LIG4, PAXIP1, DDX3X, VCAM1, METTL18, ITGA4, gag-pol, PAN2, CD81, IGSF8, ICAM1, NPM1, EXOSC6, CDK18, TARDBP, HECW2, rev, HUWE1, RNF2, HERC2, EPB41L1, PRRC2B, EIF3CL, EIF3J, TRIP12, DNAJA4, DCAF10, EIF2B5, CPNE8, EIF5, LMAN1, MYL9, NDUFB5, RPS13, SETD2, TRA2B, UBR5, YBX1, NUMA1, PDCD4, POLR1C, RAN, RPL37A, SLC3A2, SRRM1, SRSF6, SRSF7, SUB1, TMED2, SFN, NTRK1, TGFBR2, KIF11, MYO1C, RPL10, NES, L1TD1, Cct2, Cct4, Cct8, Gspt1, Eif3e, Coro1c, Rpl35, Srp72, GAN, GLI1, RC3H1, ZNF746, CERKL, EIF4A1, CYLD, DLD, HSD17B10, SOD1, G3BP1, CCND2, BRCA1, TES, BRD1, CFTR, ZNF598, KCTD12, ACO2, UBE2M, PYHIN1, EFTUD2, NFKB1, TNIP2, RNF4, ESR2, HEXIM1, RECQL4, TP53, Prkaa1, Prkab1, KIAA1429, EIF4B, ATG16L1, METTL3, TPT1, NR2C2, KRAS, GBAS, CD74, DDX60, ITFG1, BIRC3, NFX1, WWP2, HTT, PLEKHA4, ZC3H18, RAB5A, IFT172, C5orf58, nsp1, ESR1, ERCC6, EIF4A2, DUX4, KIF14, nsp2ab, NMRAL1, BRD4, CIC, Apc2, RBM39, RIN3, EIF4E, EIF4G3, EIF4EBP2, EIF4ENIF1, EIF4EBP1, ANGEL1, AR, UFL1, DDRGK1, SKA3, FZR1, WDR5, NUDCD2, NAA40, STX18, EP300, CCNF, KLF16, KLF8,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF3I	chr1	32694819	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF3I	HNSC	chr1	32696783	32696783	G	A	Missense_Mutation		5
EIF3I	BRCA	chr1	32691811	32691811	G	A	Missense_Mutation	p.R97Q	4
EIF3I	BRCA	chr1	32691906	32691906	G	A	Missense_Mutation	p.D129N	3
EIF3I	UCEC	chr1	32691819	32691819	G	A	Missense_Mutation	p.G100S	3
EIF3I	BRCA	chr1	32694340	32694340	A	G	Missense_Mutation	p.T218A	3
EIF3I	BRCA	chr1	32694368	32694369	GG	-	Frame_Shift_Del	p.R227fs	3
EIF3I	BLCA	chr1	32690056	32690056	G	C	Missense_Mutation	p.R77P	3
EIF3I	BLCA	chr1	32691917	32691917	G	C	Missense_Mutation	p.Q132H	3
EIF3I	PRAD	chr1	32690027	32690027	C	T	Silent	p.V67V	3
EIF3I	UCS	chr1	32694780	32694780	C	A	Silent	p.T258T	3
EIF3I	COAD	chr1	32694367	32694367	C	T	Missense_Mutation	p.R227W	3
EIF3I	SKCM	chr1	32688147	32688147	C	T	Silent	p.I4I	2
EIF3I	LGG	chr1	32688225	32688225	G	A	Silent	p.K30K	2
EIF3I	SKCM	chr1	32691786	32691786	C	T	Missense_Mutation	p.L89F	2
EIF3I	LUAD	chr1	32694336	32694336	C	T	Silent	p.D216D	2
EIF3I	UCEC	chr1	32689634	32689634	G	T	Splice_Site	e3-1	2
EIF3I	COAD	chr1	32692072	32692072	C	A	Missense_Mutation	p.L157M	2
EIF3I	SKCM	chr1	32694346	32694346	C	T	Missense_Mutation	p.L220F	2
EIF3I	LGG	chr1	32688225	32688225	G	A	Silent		2
EIF3I	CESC	chr1	32696563	32696563	G	C	Missense_Mutation		2
EIF3I	LUAD	chr1	32696570	32696570	G	C	Missense_Mutation	p.K282N	2
EIF3I	UCEC	chr1	32696725	32696725	C	T	Silent	p.S302	2
EIF3I	BLCA	chr1	32688180	32688180	G	C	Missense_Mutation	p.Q15H	2
EIF3I	STAD	chr1	32694368	32694368	G	A	Missense_Mutation	p.R227Q	2
EIF3I	UCEC	chr1	32696777	32696777	G	A	Missense_Mutation	p.E320K	2
EIF3I	CESC	chr1	32692106	32692106	G	A	Missense_Mutation		2
EIF3I	BLCA	chr1	32692108	32692108	G	C	Missense_Mutation	p.E169Q	2
EIF3I	CESC	chr1	32694789	32694789	G	T	Missense_Mutation		2
EIF3I	STAD	chr1	32696575	32696575	A	G	Missense_Mutation	p.H284R	2
EIF3I	CESC	chr1	32696563	32696563	G	C	Missense_Mutation	p.R280T	2
EIF3I	STAD	chr1	32694410	32694410	A	G	Missense_Mutation	p.Y241C	2
EIF3I	HNSC	chr1	32696783	32696783	G	A	Missense_Mutation	p.E322K	2
EIF3I	STAD	chr1	32690021	32690021	G	A	Silent	p.K65K	2
EIF3I	BLCA	chr1	32690056	32690056	G	C	Missense_Mutation		2
EIF3I	BRCA	chr1	32694376	32694376	C	T	Missense_Mutation	p.R230C	2
EIF3I	STAD	chr1	32689716	32689716	G	A	Missense_Mutation	p.A60T	2
EIF3I	LIHC	chr1	32691869	32691869	G	-	Frame_Shift_Del	p.M116fs	2
EIF3I	BLCA	chr1	32691917	32691917	G	C	Missense_Mutation		2
EIF3I	LIHC	chr1	32690034	32690034	G	-	Frame_Shift_Del	p.G70fs	1
EIF3I	COAD	chr1	32696723	32696723	A	G	Missense_Mutation	p.S302G	1
EIF3I	BLCA	chr1	32692108	32692108	G	C	Missense_Mutation		1
EIF3I	LIHC	chr1	32694401	32694401	C	-	Frame_Shift_Del	p.S238fs	1
EIF3I	UCEC	chr1	32694329	32694329	T	-	Frame_Shift_Del	p.L214_splice	1
EIF3I	COAD	chr1	32690044	32690044	A	T	Missense_Mutation	p.D73V	1
EIF3I	BLCA	chr1	32696762	32696762	G	A	Missense_Mutation		1
EIF3I	LGG	chr1	32688215	32688215	C	T	Missense_Mutation	p.T27I	1
EIF3I	GBM	chr1	32689675	32689675	G	A	Missense_Mutation		1
EIF3I	STAD	chr1	32691831	32691831	G	-	Frame_Shift_Del		1
EIF3I	LGG	chr1	32688215	32688215	C	T	Missense_Mutation		1
EIF3I	CESC	chr1	32692070	32692070	C	T	Missense_Mutation		1
EIF3I	LUAD	chr1	32691889	32691889	G	A	Missense_Mutation	p.S123N	1
EIF3I	HNSC	chr1	32694413	32694413	A	G	Missense_Mutation		1
EIF3I	LGG	chr1	32690063	32690063	G	T	Missense_Mutation		1
EIF3I	OV	chr1	32688148	32688148	C	G	Missense_Mutation	p.L5V	1
EIF3I	UCS	chr1	32694780	32694780	C	A	Silent		1
EIF3I	LIHC	chr1	32696573	32696573	T	C	Silent		1
EIF3I	HNSC	chr1	32694753	32694753	T	C	Silent		1
EIF3I	BLCA	chr1	32696762	32696762	G	A	Missense_Mutation	p.D315N	1
EIF3I	LIHC	chr1	32692130	32692131	-	-	Frame_Shift_Ins		1
EIF3I	READ	chr1	32691860	32691860	C	T	Silent	p.D113D	1
EIF3I	ACC	chr1	32694136	32694136	C	T	Missense_Mutation	p.R189W	1
EIF3I	BLCA	chr1	32692075	32692075	G	A	Missense_Mutation	p.G158R	1
EIF3I	LIHC	chr1	32687989	32687989	C	T	Missense_Mutation		1
EIF3I	CESC	chr1	32692106	32692106	G	A	Missense_Mutation	p.G168E	1
EIF3I	SARC	chr1	32690050	32690050	G	T	Missense_Mutation		1
EIF3I	HNSC	chr1	32694413	32694413	A	G	Missense_Mutation	p.D242G	1
EIF3I	LIHC	chr1	32696740	32696740	T	C	Silent	p.G307G	1
EIF3I	CESC	chr1	32694789	32694789	G	T	Missense_Mutation	p.R261S	1
EIF3I	SARC	chr1	32696724	32696724	G	T	Missense_Mutation		1
EIF3I	BLCA	chr1	32688180	32688180	G	C	Missense_Mutation		1
EIF3I	KIRC	chr1	32694809	32694809	G	-	Splice_Site	p.R268_splice	1
EIF3I	SARC	chr1	32694794	32694794	G	T	Missense_Mutation		1
EIF3I	UCEC	chr1	32689650	32689650	T	C	Missense_Mutation	p.Y38H	1
EIF3I	KIRP	chr1	32694404	32694404	C	A	Missense_Mutation	p.P239H	1

Copy number variation (CNV) of EIF3I
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF3I
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
84758	N/A	EC460443	EIF3I	chr1	32694210	+	EIF3I	chr1	32694100	+
25871	STAD	TCGA-FP-8210-01A	EIF3I	chr1	32697130	+	GSTK1	chr7	142965882	+
102100	N/A	DC421012	EIF3I	chr1	32692041	+	NUP98	chr11	3707749	-
100334	N/A	BG031463	EIF3I	chr1	32696890	+	PPP1R36	chr14	65050303	+
82220	COAD	TCGA-AA-A03J-01A	EIF3I	chr1	32690076	+	SLC12A2	chr5	127486933	+
76336	N/A	BG566325	EIF3I	chr1	32694172	+	ST5	chr11	8813490	-
101110	N/A	AI682532	EIF3I	chr1	32697093	-	YPEL1	chr22	22070048	+
35817	N/A	BG574688	EIF3I	chr1	32697202	+	ZBTB8B	chr1	32709663	+
84758	STAD	TCGA-BR-A4J1	HDAC1	chr1	32768334	+	EIF3I	chr1	32694099	+
84758	STAD	TCGA-BR-A4J1-01A	HDAC1	chr1	32768334	-	EIF3I	chr1	32694100	+
84758	HNSC	TCGA-CR-7379	KPNA6	chr1	32573735	+	EIF3I	chr1	32694099	+
84758	HNSC	TCGA-CR-7379	KPNA6	chr1	32573735	+	EIF3I	chr1	32694100	+
84758	N/A	AA032022	LRRC47	chr1	3697481	-	EIF3I	chr1	32694858	+
84758	N/A	BC015407	MTMR9LP	chr1	32697345	-	EIF3I	chr1	32694098	+
84758	N/A	AA838660	SLX4	chr16	3654215	-	EIF3I	chr1	32697198	-
84759	N/A	AU123912	SNRPA	chr19	41265371	+	EIF3I	chr1	32688010	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	EIF3I	0.00396151978380236	0.11
ACC	EIF3I	0.00889168942041995	0.24
THYM	EIF3I	0.0144316947010834	0.38
KIRC	EIF3I	0.0342844135303652	0.86

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	EIF3I	0.00809268195557211	0.26
BRCA	EIF3I	0.0328551890579737	0.99
SKCM	EIF3I	0.0179323470182845	0.56
OV	EIF3I	0.0329395530676505	0.99
SARC	EIF3I	0.000894599502873601	0.03

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0007102	Malignant tumor of colon	1	CTD_human