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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF2B3 (NCBI Gene ID:8891)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF2B3
	Gene ID: 8891
	Gene Symbol	EIF2B3
	Gene ID	8891
	Gene Name	eukaryotic translation initiation factor 2B subunit gamma
	Synonyms	EIF-2B\|EIF2Bgamma
	Cytomap	1p34.1
	Type of Gene	protein-coding
	Description	translation initiation factor eIF-2B subunit gammaeIF-2B GDP-GTP exchange factor subunit gammaeukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
	Modification date	20200313
	UniProtAcc	Q9NR50

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF2B3	GO:0006413	translational initiation	10900014\|16289705
Hgene	EIF2B3	GO:0050852	T cell receptor signaling pathway	8626696

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF2B3	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF2B3[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF2B3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000360403	45323375	45323479	Frame-shift
ENST00000360403	45340349	45340498	Frame-shift
ENST00000360403	45341289	45341367	In-frame
ENST00000360403	45345489	45345680	Frame-shift
ENST00000360403	45347283	45347411	Frame-shift
ENST00000360403	45363026	45363116	In-frame
ENST00000360403	45392299	45392411	Frame-shift
ENST00000360403	45446692	45446849	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000360403	45341289	45341367	1676	1103	1180	452	325	351
ENST00000360403	45363026	45363116	1676	694	783	452	189	218

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9NR50	325	351	1	452	Chain	ID=PRO_0000156079;Note=Translation initiation factor eIF-2B subunit gamma
Q9NR50	189	218	1	452	Chain	ID=PRO_0000156079;Note=Translation initiation factor eIF-2B subunit gamma
Q9NR50	325	351	346	346	Natural variant	ID=VAR_068472;Note=In VWM. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19158808;Dbxref=dbSNP:rs119474039,PMID:19158808
Q9NR50	189	218	185	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6CAJ
Q9NR50	189	218	191	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6CAJ
Q9NR50	189	218	209	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:6CAJ

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	EIF2B3	2.17795043401278	0.000216901302337646
THCA	EIF2B3	-2.27193247701228	0.000372452864704637
HNSC	EIF2B3	-1.66956934127194	0.00459462782941955
COAD	EIF2B3	-1.60183733464354	0.00938254594802858
BRCA	EIF2B3	-1.42398409637427	6.27134207487183e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LIHC	EIF2B3	-0.066205036	0.030886722

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF2B3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	EIF2B3	AK2	0.820397129	9.61E-13
DLBC	Cell metabolism gene	EIF2B3	PSMA5	0.836566656	1.32E-13
GBM	Cell metabolism gene	EIF2B3	PSMA5	0.813717006	6.57E-42
LGG	Cell metabolism gene	EIF2B3	PSMA5	0.801684292	4.34E-120
THYM	Cell metabolism gene	EIF2B3	PAFAH1B3	0.800056451	2.13E-28
THYM	Cell metabolism gene	EIF2B3	SNRPD1	0.801062719	1.62E-28
THYM	Cell metabolism gene	EIF2B3	PSME1	0.801772405	1.34E-28
THYM	Cell metabolism gene	EIF2B3	PSMA4	0.804037957	7.23E-29
THYM	Cell metabolism gene	EIF2B3	TIMM10	0.80513549	5.35E-29
THYM	Cell metabolism gene	EIF2B3	PSMA5	0.805443465	4.91E-29
THYM	Cell metabolism gene	EIF2B3	LSM4	0.805554363	4.76E-29
THYM	Cell metabolism gene	EIF2B3	SEC61G	0.806294577	3.88E-29
THYM	Cell metabolism gene	EIF2B3	SNRPB	0.806883329	3.29E-29
THYM	Cell metabolism gene	EIF2B3	CCT7	0.80806784	2.37E-29
THYM	Cell metabolism gene	EIF2B3	PGLS	0.808334102	2.19E-29
THYM	Cell metabolism gene	EIF2B3	GUK1	0.809289667	1.68E-29
THYM	Cell metabolism gene	EIF2B3	PGP	0.812438612	6.83E-30
THYM	Cell metabolism gene	EIF2B3	SRM	0.813608651	4.87E-30
THYM	Cell metabolism gene	EIF2B3	UROS	0.814119438	4.20E-30
THYM	Cell metabolism gene	EIF2B3	NANS	0.815421061	2.87E-30
THYM	Cell metabolism gene	EIF2B3	EBP	0.819645443	8.18E-31
THYM	Cell metabolism gene	EIF2B3	PSMB6	0.820217909	6.89E-31
THYM	Cell metabolism gene	EIF2B3	POLR2H	0.82338452	2.62E-31
THYM	Cell metabolism gene	EIF2B3	NOP56	0.824462256	1.88E-31
THYM	Cell metabolism gene	EIF2B3	SLC27A5	0.825635939	1.30E-31
THYM	Cell metabolism gene	EIF2B3	ITPA	0.826632143	9.54E-32
THYM	Cell metabolism gene	EIF2B3	POLR2E	0.828140107	5.93E-32
THYM	Cell metabolism gene	EIF2B3	POLA2	0.830748959	2.57E-32
THYM	Cell metabolism gene	EIF2B3	PSMB2	0.832107158	1.65E-32
THYM	Cell metabolism gene	EIF2B3	PMPCA	0.836433136	3.96E-33
THYM	Cell metabolism gene	EIF2B3	GALK1	0.840266862	1.08E-33
THYM	Cell metabolism gene	EIF2B3	TALDO1	0.840372038	1.04E-33
THYM	Cell metabolism gene	EIF2B3	EXOSC4	0.840992806	8.38E-34
THYM	Cell metabolism gene	EIF2B3	PSMB1	0.843016161	4.14E-34
THYM	Cell metabolism gene	EIF2B3	OAZ1	0.843705605	3.25E-34
THYM	Cell metabolism gene	EIF2B3	IDH3B	0.844751031	2.25E-34
THYM	Cell metabolism gene	EIF2B3	TIMM8B	0.845885642	1.50E-34
THYM	Cell metabolism gene	EIF2B3	PSMD8	0.849791972	3.63E-35
THYM	Cell metabolism gene	EIF2B3	TIMM50	0.851042523	2.28E-35
THYM	Cell metabolism gene	EIF2B3	PSMB3	0.857397443	2.04E-36
THYM	Cell metabolism gene	EIF2B3	MVD	0.860323364	6.43E-37
THYM	Cell metabolism gene	EIF2B3	PSMD13	0.860394478	6.25E-37
THYM	Cell metabolism gene	EIF2B3	LSM2	0.862946489	2.24E-37
THYM	Cell metabolism gene	EIF2B3	ACOT8	0.862999475	2.19E-37
THYM	Cell metabolism gene	EIF2B3	PSMB7	0.864937498	9.89E-38
THYM	Cell metabolism gene	EIF2B3	SNRPD2	0.868816032	1.94E-38
THYM	Cell metabolism gene	EIF2B3	DTYMK	0.871437823	6.27E-39
THYM	Cell metabolism gene	EIF2B3	FPGS	0.874515136	1.61E-39
THYM	Cell metabolism gene	EIF2B3	TIMM13	0.887246466	3.89E-42
THYM	Cell metabolism gene	EIF2B3	PSMC3	0.888803005	1.77E-42
THYM	Cell metabolism gene	EIF2B3	POLD2	0.899578257	5.44E-45
THYM	CGC	EIF2B3	RBM10	0.808317909	2.20E-29
THYM	CGC	EIF2B3	SDHAF2	0.85534876	4.50E-36
THYM	CGC	EIF2B3	TFPT	0.870353679	1.00E-38
THYM	Epifactor	EIF2B3	TRIM28	0.801080763	1.62E-28
THYM	Epifactor	EIF2B3	PAF1	0.802202863	1.19E-28
THYM	Epifactor	EIF2B3	PPM1G	0.804174178	6.97E-29
THYM	Epifactor	EIF2B3	LAS1L	0.806867933	3.31E-29
THYM	Epifactor	EIF2B3	C17orf49	0.817147176	1.73E-30
THYM	Epifactor	EIF2B3	PRMT1	0.830112466	3.16E-32
THYM	Epifactor	EIF2B3	PPP4C	0.833526868	1.04E-32
THYM	Epifactor	EIF2B3	NOC2L	0.837602372	2.67E-33
THYM	Epifactor	EIF2B3	EXOSC4	0.840992806	8.38E-34
THYM	Epifactor	EIF2B3	RRP8	0.842519303	4.93E-34
THYM	Epifactor	EIF2B3	RUVBL2	0.844656735	2.32E-34
THYM	Epifactor	EIF2B3	MBD3	0.846957309	1.02E-34
THYM	Epifactor	EIF2B3	FBL	0.852843962	1.16E-35
THYM	Epifactor	EIF2B3	BRMS1	0.854508177	6.20E-36
THYM	Epifactor	EIF2B3	PRPF31	0.86254636	2.63E-37
THYM	Epifactor	EIF2B3	TFPT	0.870353679	1.00E-38
THYM	IUPHAR	EIF2B3	TRIM28	0.801080763	1.62E-28
THYM	IUPHAR	EIF2B3	PSMB6	0.820217909	6.89E-31
THYM	IUPHAR	EIF2B3	SLC27A5	0.825635939	1.30E-31
THYM	IUPHAR	EIF2B3	PRMT1	0.830112466	3.16E-32
THYM	IUPHAR	EIF2B3	PSMB2	0.832107158	1.65E-32
THYM	IUPHAR	EIF2B3	EGLN2	0.836029982	4.53E-33
THYM	IUPHAR	EIF2B3	PSMB1	0.843016161	4.14E-34
THYM	IUPHAR	EIF2B3	MVD	0.860323364	6.43E-37
THYM	Kinase	EIF2B3	TRIM28	0.801080763	1.62E-28
THYM	TF	EIF2B3	ZNF428	0.802640403	1.06E-28
THYM	TF	EIF2B3	PIN1	0.832060524	1.68E-32
THYM	TF	EIF2B3	MBD3	0.846957309	1.02E-34
THYM	TSG	EIF2B3	PHB	0.808625284	2.02E-29
THYM	TSG	EIF2B3	PIN1	0.832060524	1.68E-32
THYM	TSG	EIF2B3	BRMS1	0.854508177	6.20E-36
THYM	TSG	EIF2B3	TSSC4	0.863752881	1.61E-37
UCS	Cell metabolism gene	EIF2B3	PAFAH1B3	0.800056451	2.13E-28
UCS	Cell metabolism gene	EIF2B3	SNRPD1	0.801062719	1.62E-28
UCS	Cell metabolism gene	EIF2B3	PSME1	0.801772405	1.34E-28
UCS	Cell metabolism gene	EIF2B3	PSMA4	0.804037957	7.23E-29
UCS	Cell metabolism gene	EIF2B3	TIMM10	0.80513549	5.35E-29
UCS	Cell metabolism gene	EIF2B3	PSMA5	0.805443465	4.91E-29
UCS	Cell metabolism gene	EIF2B3	LSM4	0.805554363	4.76E-29
UCS	Cell metabolism gene	EIF2B3	SEC61G	0.806294577	3.88E-29
UCS	Cell metabolism gene	EIF2B3	SNRPB	0.806883329	3.29E-29
UCS	Cell metabolism gene	EIF2B3	CCT7	0.80806784	2.37E-29
UCS	Cell metabolism gene	EIF2B3	PGLS	0.808334102	2.19E-29
UCS	Cell metabolism gene	EIF2B3	GUK1	0.809289667	1.68E-29
UCS	Cell metabolism gene	EIF2B3	PGP	0.812438612	6.83E-30
UCS	Cell metabolism gene	EIF2B3	SRM	0.813608651	4.87E-30
UCS	Cell metabolism gene	EIF2B3	UROS	0.814119438	4.20E-30
UCS	Cell metabolism gene	EIF2B3	NANS	0.815421061	2.87E-30
UCS	Cell metabolism gene	EIF2B3	EBP	0.819645443	8.18E-31
UCS	Cell metabolism gene	EIF2B3	PSMB6	0.820217909	6.89E-31
UCS	Cell metabolism gene	EIF2B3	POLR2H	0.82338452	2.62E-31
UCS	Cell metabolism gene	EIF2B3	NOP56	0.824462256	1.88E-31
UCS	Cell metabolism gene	EIF2B3	SLC27A5	0.825635939	1.30E-31
UCS	Cell metabolism gene	EIF2B3	ITPA	0.826632143	9.54E-32
UCS	Cell metabolism gene	EIF2B3	POLR2E	0.828140107	5.93E-32
UCS	Cell metabolism gene	EIF2B3	POLA2	0.830748959	2.57E-32
UCS	Cell metabolism gene	EIF2B3	PSMB2	0.832107158	1.65E-32
UCS	Cell metabolism gene	EIF2B3	PMPCA	0.836433136	3.96E-33
UCS	Cell metabolism gene	EIF2B3	GALK1	0.840266862	1.08E-33
UCS	Cell metabolism gene	EIF2B3	TALDO1	0.840372038	1.04E-33
UCS	Cell metabolism gene	EIF2B3	EXOSC4	0.840992806	8.38E-34
UCS	Cell metabolism gene	EIF2B3	PSMB1	0.843016161	4.14E-34
UCS	Cell metabolism gene	EIF2B3	OAZ1	0.843705605	3.25E-34
UCS	Cell metabolism gene	EIF2B3	IDH3B	0.844751031	2.25E-34
UCS	Cell metabolism gene	EIF2B3	TIMM8B	0.845885642	1.50E-34
UCS	Cell metabolism gene	EIF2B3	PSMD8	0.849791972	3.63E-35
UCS	Cell metabolism gene	EIF2B3	TIMM50	0.851042523	2.28E-35
UCS	Cell metabolism gene	EIF2B3	PSMB3	0.857397443	2.04E-36
UCS	Cell metabolism gene	EIF2B3	MVD	0.860323364	6.43E-37
UCS	Cell metabolism gene	EIF2B3	PSMD13	0.860394478	6.25E-37
UCS	Cell metabolism gene	EIF2B3	LSM2	0.862946489	2.24E-37
UCS	Cell metabolism gene	EIF2B3	ACOT8	0.862999475	2.19E-37
UCS	Cell metabolism gene	EIF2B3	PSMB7	0.864937498	9.89E-38
UCS	Cell metabolism gene	EIF2B3	SNRPD2	0.868816032	1.94E-38
UCS	Cell metabolism gene	EIF2B3	DTYMK	0.871437823	6.27E-39
UCS	Cell metabolism gene	EIF2B3	FPGS	0.874515136	1.61E-39
UCS	Cell metabolism gene	EIF2B3	TIMM13	0.887246466	3.89E-42
UCS	Cell metabolism gene	EIF2B3	PSMC3	0.888803005	1.77E-42
UCS	Cell metabolism gene	EIF2B3	POLD2	0.899578257	5.44E-45
UCS	CGC	EIF2B3	RBM10	0.808317909	2.20E-29
UCS	CGC	EIF2B3	SDHAF2	0.85534876	4.50E-36
UCS	CGC	EIF2B3	TFPT	0.870353679	1.00E-38
UCS	Epifactor	EIF2B3	TRIM28	0.801080763	1.62E-28
UCS	Epifactor	EIF2B3	PAF1	0.802202863	1.19E-28
UCS	Epifactor	EIF2B3	PPM1G	0.804174178	6.97E-29
UCS	Epifactor	EIF2B3	LAS1L	0.806867933	3.31E-29
UCS	Epifactor	EIF2B3	C17orf49	0.817147176	1.73E-30
UCS	Epifactor	EIF2B3	PRMT1	0.830112466	3.16E-32
UCS	Epifactor	EIF2B3	PPP4C	0.833526868	1.04E-32
UCS	Epifactor	EIF2B3	NOC2L	0.837602372	2.67E-33
UCS	Epifactor	EIF2B3	EXOSC4	0.840992806	8.38E-34
UCS	Epifactor	EIF2B3	RRP8	0.842519303	4.93E-34
UCS	Epifactor	EIF2B3	RUVBL2	0.844656735	2.32E-34
UCS	Epifactor	EIF2B3	MBD3	0.846957309	1.02E-34
UCS	Epifactor	EIF2B3	FBL	0.852843962	1.16E-35
UCS	Epifactor	EIF2B3	BRMS1	0.854508177	6.20E-36
UCS	Epifactor	EIF2B3	PRPF31	0.86254636	2.63E-37
UCS	Epifactor	EIF2B3	TFPT	0.870353679	1.00E-38
UCS	IUPHAR	EIF2B3	TRIM28	0.801080763	1.62E-28
UCS	IUPHAR	EIF2B3	PSMB6	0.820217909	6.89E-31
UCS	IUPHAR	EIF2B3	SLC27A5	0.825635939	1.30E-31
UCS	IUPHAR	EIF2B3	PRMT1	0.830112466	3.16E-32
UCS	IUPHAR	EIF2B3	PSMB2	0.832107158	1.65E-32
UCS	IUPHAR	EIF2B3	EGLN2	0.836029982	4.53E-33
UCS	IUPHAR	EIF2B3	PSMB1	0.843016161	4.14E-34
UCS	IUPHAR	EIF2B3	MVD	0.860323364	6.43E-37
UCS	Kinase	EIF2B3	TRIM28	0.801080763	1.62E-28
UCS	TF	EIF2B3	ZNF428	0.802640403	1.06E-28
UCS	TF	EIF2B3	PIN1	0.832060524	1.68E-32
UCS	TF	EIF2B3	MBD3	0.846957309	1.02E-34
UCS	TSG	EIF2B3	PHB	0.808625284	2.02E-29
UCS	TSG	EIF2B3	PIN1	0.832060524	1.68E-32
UCS	TSG	EIF2B3	BRMS1	0.854508177	6.20E-36
UCS	TSG	EIF2B3	TSSC4	0.863752881	1.61E-37

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	EIF2B3	EIF2B5	-2.17335102876885	0.000112780019881286
BRCA	EIF2B3	EIF5	-1.16704316213885	0.00107943958337404
LIHC	EIF2B3	EIF2S3	-4.62530933210412	0.00154404530385922
LIHC	EIF2B3	EIF2AK4	-4.60322890059861	0.00188131470650586
LUSC	EIF2B3	EIF2AK4	1.88005113022765	0.00283162168555847
KICH	EIF2B3	EIF2S2	-1.06278646532411	0.00308787822723389
COAD	EIF2B3	EIF2B5	-3.82949281161428	0.011966735124588
COAD	EIF2B3	EIF2B4	-1.63825654493327	0.0204286277294159
CHOL	EIF2B3	EIF2B2	-1.61211785827489	0.02734375
STAD	EIF2B3	EIF2B1	1.06970835543362	0.0324882394634187
ESCA	EIF2B3	EIF2S3	-1.31322237574718	0.0419921875
BRCA	EIF2B3	EIF2S2	-2.57303037687825	1.70212120584918e-09
LUSC	EIF2B3	EIF2B4	-4.42561330574195	1.73490174268501e-07
PRAD	EIF2B3	EIF2B4	1.20626610203239	1.94411875335162e-07
LUAD	EIF2B3	EIF2B4	-1.76566297999877	3.09848396407815e-08
STAD	EIF2B3	EIF2S2	-2.13186277769467	3.17529775202275e-05
LIHC	EIF2B3	EIF2B2	-1.75683032348821	4.08414278982391e-05
LUAD	EIF2B3	EIF2B2	-3.96081365689084	4.19177862905507e-09
LIHC	EIF2B3	EIF5	-2.12060405382854	4.66164898670786e-08
KIRP	EIF2B3	EIF2B1	-2.14953108463177	5.24520874023438e-06
LUAD	EIF2B3	EIF2B1	-2.39668434561352	5.70558004016916e-06
KIRC	EIF2B3	EIF2B1	-1.83635928054145	7.43306349049898e-12
KICH	EIF2B3	EIF2B4	1.3794276859253	8.16583633422851e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF2B3

EIF2B1, STC2, NDUFB8, EIF2B5, EIF2B4, EIF2B2, EGFR, FBXO6, ABCF1, C14orf166, RTCB, NELFB, YBX3, DDX1, DHX9, DIMT1, EDC4, EIF3C, FKBP3, FLII, G3BP1, HNRNPM, HNRNPU, IGF2BP3, ILF2, MRE11A, NMT1, QARS, RFC4, VTI1B, STX12, ECH1, CA14, GPR183, PNKD, P2RX4, OPN3, SPN, PTGER3, SCN2B, PVRL4, HNRNPA1, XPO1, CDC42, ZWINT, Cdk1, GYPB, SYT1, SIGLECL1, EPHA1, TMEM206, UXS1, FZD10, CD70, CD4, HTR2C, SMDT1, EGLN3, MYC, KIAA1429, NR2C2, KRAS, CD74, BCL2L14, P2RY6, SLC15A3, TNFSF13B, UNC93B1, Dppa3, DUSP3, LMBR1L, PLEKHA4, MAP1LC3B, EXD2, LRRC59, TULP3, DDRGK1, ATG7, C3orf18, BTNL9, BTC, CD226, CLEC2B, TACSTD2, GPR17, GCH1, FGF14, SYT2, EFNB1, SEC62, TPST2, TNFSF14, TMEM55A, TMEM55B, CACNG4, COMTD1, ENTPD2, PTAFR, FBXO32,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF2B3	chr1	45316222	A	G	single_nucleotide_variant	Likely_benign	Leukoencephalopathy_with_vanishing_white_matter	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
EIF2B3	chr1	45316341	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
EIF2B3	chr1	45316357	G	A	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
EIF2B3	chr1	45316422	G	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
EIF2B3	chr1	45316568	G	A	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
EIF2B3	chr1	45316663	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant
EIF2B3	chr1	45323395	G	A	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
EIF2B3	chr1	45323405	A	G	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
EIF2B3	chr1	45323408	A	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
EIF2B3	chr1	45323474	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
EIF2B3	chr1	45323518	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45340282	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
EIF2B3	chr1	45340342	A	C	single_nucleotide_variant	Benign/Likely_benign	Leukoencephalopathy_with_vanishing_white_matter\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
EIF2B3	chr1	45340351	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45340411	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45340422	G	A	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45340703	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45341279	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45341306	A	G	single_nucleotide_variant	Pathogenic	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45341318	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45341360	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Leukoencephalopathy_with_vanishing_white_matter\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45345446	T	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45345481	T	C	single_nucleotide_variant	Benign/Likely_benign	Leukoencephalopathy_with_vanishing_white_matter\|not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45345483	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45345530	C	T	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45345544	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45345601	G	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45345632	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter\|not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45345686	G	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45347287	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45347325	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45347362	G	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45347394	C	G	single_nucleotide_variant	Pathogenic	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45347394	C	T	single_nucleotide_variant	Pathogenic	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45362992	T	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45363049	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45363050	G	A	single_nucleotide_variant	Benign/Likely_benign	Leukoencephalopathy_with_vanishing_white_matter\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45363092	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45363250	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45363300	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45392358	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45392363	A	G	single_nucleotide_variant	Likely_pathogenic	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45392402	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45407181	CT	C	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
EIF2B3	chr1	45407190	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45407193	C	G	single_nucleotide_variant	Benign	Leukoencephalopathy_with_vanishing_white_matter\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45407202	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45407203	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45407208	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45407244	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45443766	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45443894	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45444004	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45444009	C	T	single_nucleotide_variant	Likely_pathogenic	Leukoencephalopathy_with_vanishing_white_matter\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45444021	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Leukoencephalopathy_with_vanishing_white_matter\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45444038	G	A	single_nucleotide_variant	Benign	Leukoencephalopathy_with_vanishing_white_matter\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45444057	A	G	single_nucleotide_variant	Likely_benign	Leukoencephalopathy_with_vanishing_white_matter\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45444092	T	A	single_nucleotide_variant	Benign/Likely_benign	Leukoencephalopathy_with_vanishing_white_matter\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45444092	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45444136	T	C	single_nucleotide_variant	Benign/Likely_benign	Leukoencephalopathy_with_vanishing_white_matter\|not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45444293	CTTTTTTTTTT	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45444293	CTTTTTTTTTTTTTTTT	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
EIF2B3	chr1	45446707	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45446711	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45446744	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45446752	A	G	single_nucleotide_variant	Likely_pathogenic	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45446761	A	T	single_nucleotide_variant	Pathogenic	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45446762	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45446796	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45446797	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45446809	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2B3	chr1	45446826	T	G	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2B3	chr1	45446840	T	G	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
EIF2B3	chr1	45452181	G	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
EIF2B3	chr1	45452211	C	T	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
EIF2B3	chr1	45452227	G	C	single_nucleotide_variant	Benign	Leukoencephalopathy_with_vanishing_white_matter	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
EIF2B3	chr1	45452310	T	G	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
EIF2B3	chr1	45452327	G	A	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter
EIF2B3	chr1	45452327	G	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy_with_vanishing_white_matter
EIF2B3	chr1	45452336	T	A	single_nucleotide_variant	Benign	Leukoencephalopathy_with_vanishing_white_matter

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF2B3	BLCA	chr1	45407182	45407182	T	-	Frame_Shift_Del	p.K150fs	4
EIF2B3	CESC	chr1	45444038	45444038	G	A	Silent		4
EIF2B3	UCEC	chr1	45363068	45363068	G	T	Nonsense_Mutation	p.Y205*	3
EIF2B3	HNSC	chr1	45444037	45444037	C	T	Missense_Mutation	p.A82T	3
EIF2B3	BRCA	chr1	45323458	45323458	G	A	Silent	p.V408	3
EIF2B3	BRCA	chr1	45363093	45363093	G	A	Missense_Mutation	p.T197M	3
EIF2B3	LIHC	chr1	45347301	45347301	T	-	Frame_Shift_Del	p.K256fs	3
EIF2B3	STAD	chr1	45407182	45407183	TT	-	Frame_Shift_Del	p.150_151del	3
EIF2B3	LUAD	chr1	45323445	45323445	C	A	Missense_Mutation	p.A413S	3
EIF2B3	LUAD	chr1	45347297	45347297	C	T	Silent	p.E257E	2
EIF2B3	STAD	chr1	45345614	45345614	G	A	Missense_Mutation	p.A284V	2
EIF2B3	STAD	chr1	45407285	45407285	T	G	Missense_Mutation	p.E116A	2
EIF2B3	SARC	chr1	45407283	45407283	C	T	Missense_Mutation		2
EIF2B3	UCEC	chr1	45323387	45323387	A	C	Missense_Mutation	p.I432S	2
EIF2B3	LUAD	chr1	45407298	45407298	C	A	Missense_Mutation	p.V112F	2
EIF2B3	UCEC	chr1	45340446	45340446	G	A	Missense_Mutation	p.S369F	2
EIF2B3	HNSC	chr1	45407189	45407189	T	G	Missense_Mutation	p.K148T	2
EIF2B3	SARC	chr1	45407283	45407283	C	T	Missense_Mutation	p.V117I	2
EIF2B3	UCEC	chr1	45341352	45341352	A	G	Missense_Mutation	p.S331P	2
EIF2B3	HNSC	chr1	45341334	45341334	C	G	Missense_Mutation	p.E337Q	2
EIF2B3	LIHC	chr1	45444070	45444070	T	-	Frame_Shift_Del	p.M71fs	2
EIF2B3	UCEC	chr1	45363050	45363050	G	A	Silent	p.S32L	2
EIF2B3	STAD	chr1	45392393	45392393	A	C	Missense_Mutation	p.I158S	2
EIF2B3	KIRC	chr1	45347334	45347334	C	-	Frame_Shift_Del	p.G245fs	2
EIF2B3	SKCM	chr1	45316635	45316635	G	A	Silent	p.L449L	2
EIF2B3	CESC	chr1	45347294	45347294	C	T	Silent		2
EIF2B3	LIHC	chr1	45446717	45446717	G	-	Frame_Shift_Del	p.L43fs	2
EIF2B3	SKCM	chr1	45347380	45347380	G	A	Missense_Mutation	p.P230S	2
EIF2B3	UCEC	chr1	45392331	45392331	C	A	Nonsense_Mutation	p.E179*	2
EIF2B3	STAD	chr1	45392349	45392349	C	T	Missense_Mutation	p.E173K	2
EIF2B3	CESC	chr1	45444077	45444077	C	G	Missense_Mutation		2
EIF2B3	SKCM	chr1	45392316	45392316	C	T	Missense_Mutation	p.G184R	2
EIF2B3	UCEC	chr1	45444090	45444090	C	T	Missense_Mutation	p.C64Y	2
EIF2B3	UCEC	chr1	45444096	45444096	G	A	Missense_Mutation	p.A62V	2
EIF2B3	STAD	chr1	45345566	45345566	C	T	Missense_Mutation	p.C300Y	2
EIF2B3	LUAD	chr1	45340362	45340362	G	C	Missense_Mutation	p.T397S	2
EIF2B3	STAD	chr1	45407190	45407190	T	C	Missense_Mutation	p.K148E	2
EIF2B3	BLCA	chr1	45444103	45444103	G	T	Missense_Mutation		1
EIF2B3	LIHC	chr1	45363027	45363027	C	T	Missense_Mutation	p.G219E	1
EIF2B3	SKCM	chr1	45341318	45341318	G	A	Missense_Mutation	p.S342L	1
EIF2B3	CESC	chr1	45347294	45347294	C	T	Silent	p.L258	1
EIF2B3	HNSC	chr1	45444037	45444037	C	T	Missense_Mutation		1
EIF2B3	READ	chr1	45323437	45323437	G	A	Silent	p.I415I	1
EIF2B3	BLCA	chr1	45347306	45347306	C	G	Missense_Mutation	p.K254N	1
EIF2B3	LIHC	chr1	45345676	45345676	G	A	Silent	p.I263I	1
EIF2B3	UCEC	chr1	45407251	45407251	T	C	Silent	p.S127S	1
EIF2B3	SKCM	chr1	45341351	45341351	G	T	Missense_Mutation	p.S331Y	1
EIF2B3	CESC	chr1	45363062	45363062	C	T	Silent	p.L207	1
EIF2B3	LUAD	chr1	45407278	45407278	C	A	Silent	p.V118V	1
EIF2B3	HNSC	chr1	45407265	45407265	C	T	Missense_Mutation	p.A123T	1
EIF2B3	LIHC	chr1	45407298	45407298	C	T	Missense_Mutation	p.V112I	1
EIF2B3	SKCM	chr1	45341322	45341322	G	A	Missense_Mutation	p.H341Y	1
EIF2B3	COAD	chr1	45323376	45323376	C	A	Missense_Mutation	p.A436S	1
EIF2B3	STAD	chr1	45345609	45345609	G	A	Nonsense_Mutation	p.R286*	1
EIF2B3	SARC	chr1	45363097	45363097	G	A	Missense_Mutation	p.H196Y	1
EIF2B3	LIHC	chr1	45340421	45340421	T	A	Silent	p.S377S	1
EIF2B3	SKCM	chr1	45323394	45323394	G	A	Nonsense_Mutation	p.Q430*	1
EIF2B3	COAD	chr1	45407195	45407195	T	G	Missense_Mutation	p.K146T	1
EIF2B3	LUSC	chr1	45347342	45347342	T	A	Silent	p.S242S	1
EIF2B3	STAD	chr1	45407191	45407191	C	T	Silent	p.G147G	1
EIF2B3	STAD	chr1	45345609	45345609	G	A	Nonsense_Mutation	p.R286X	1
EIF2B3	DLBC	chr1	45341357	45341357	A	G	Missense_Mutation	p.L329S	1
EIF2B3	LUSC	chr1	45444122	45444122	C	A	Silent	p.V53V	1
EIF2B3	STAD	chr1	45340387	45340387	T	C	Missense_Mutation	p.N389D	1
EIF2B3	SARC	chr1	45446813	45446813	C	T	Missense_Mutation		1
EIF2B3	CESC	chr1	45363062	45363062	C	T	Silent		1
EIF2B3	DLBC	chr1	45341356	45341356	C	A	Missense_Mutation	p.L329F	1
EIF2B3	LUSC	chr1	45340357	45340357	C	G	Missense_Mutation	p.E399Q	1
EIF2B3	STAD	chr1	45345609	45345609	G	A	Nonsense_Mutation		1
EIF2B3	ESCA	chr1	45407182	45407182	T	-	Frame_Shift_Del	p.A151fs	1
EIF2B3	MESO	chr1	45363050	45363050	G	T	Silent		1
EIF2B3	TGCT	chr1	45341312	45341312	G	T	Missense_Mutation	p.A344D	1
EIF2B3	KIRC	chr1	45341321	45341331	TGGACTGGTGG	-	Frame_Shift_Del	p.338_341del	1
EIF2B3	LIHC	chr1	45347321	45347321	T	-	Frame_Shift_Del	p.K249fs	1
EIF2B3	ESCA	chr1	45341323	45341323	G	T	Silent		1
EIF2B3	OV	chr1	45341323	45341323	G	C	Silent	p.V340V	1
EIF2B3	LIHC	chr1	45345682	45345682	T	C	Splice_Site		1
EIF2B3	THCA	chr1	45345632	45345632	T	C	Missense_Mutation		1
EIF2B3	LIHC	chr1	45407195	45407195	T	-	Frame_Shift_Del	p.K146fs	1
EIF2B3	SKCM	chr1	45363098	45363098	G	A	Silent	p.F195F	1
EIF2B3	HNSC	chr1	45407189	45407189	T	G	Missense_Mutation		1
EIF2B3	PAAD	chr1	45340395	45340395	G	A	Missense_Mutation		1
EIF2B3	BLCA	chr1	45446806	45446806	C	A	Missense_Mutation		1
EIF2B3	LIHC	chr1	45444054	45444054	A	G	Missense_Mutation		1
EIF2B3	THYM	chr1	45407205	45407205	G	T	Missense_Mutation	p.P143T	1
EIF2B3	CESC	chr1	45363062	45363062	C	T	Silent	p.L207L	1
EIF2B3	SKCM	chr1	45363041	45363041	G	A	Silent	p.F214F	1
EIF2B3	HNSC	chr1	45407265	45407265	C	T	Missense_Mutation		1
EIF2B3	PAAD	chr1	45340395	45340395	G	A	Missense_Mutation	p.T386I	1
EIF2B3	BLCA	chr1	45347306	45347306	C	G	Missense_Mutation		1
EIF2B3	LIHC	chr1	45444048	45444048	A	G	Missense_Mutation		1
EIF2B3	THYM	chr1	45392325	45392325	C	T	Missense_Mutation		1
EIF2B3	CESC	chr1	45424469	45424469	C	T	RNA	NULL	1
EIF2B3	SKCM	chr1	45316653	45316653	G	A	Silent	p.I443I	1
EIF2B3	STAD	chr1	45407195	45407195	T	C	Missense_Mutation	p.K146R	1
EIF2B3	HNSC	chr1	45341334	45341334	C	G	Missense_Mutation		1
EIF2B3	PRAD	chr1	45407181	45407182	-	T	Frame_Shift_Ins	p.NS150fs	1

Copy number variation (CNV) of EIF2B3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF2B3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
81224	N/A	BP431993	EIF2B3	chr1	45327445	-	CHCHD2	chr7	56170707	-
103216	OV	TCGA-57-1583-01A	EIF2B3	chr1	45392300	-	CNTNAP2	chr7	147340479	+
92692	N/A	BM145584	EIF2B3	chr1	45418781	-	ECT2	chr3	172539264	-
73862	N/A	BM145697	EIF2B3	chr1	45444333	+	EPS8	chr12	15773099	+
103205	N/A	BM193004	EIF2B3	chr1	45418818	-	GSN	chr9	124095119	-
58417	BRCA	TCGA-AR-A24L-01A	EIF2B3	chr1	45392300	-	HYI	chr1	43917990	-
98210	N/A	BM150205	EIF2B3	chr1	45382337	-	RAD51C	chr17	56773143	-
102245	TGCT	TCGA-XY-A8S2-01A	EIF2B3	chr1	45392300	-	SCMH1	chr1	41514562	-
98941	N/A	CD653813	EIF2B3	chr1	45367240	+	WDR33	chr2	128512160	+
98706	N/A	BI496857	EIF2B3	chr1	45426703	-	ZAR1	chr4	48499584	+
98568	LUAD	TCGA-44-7660-01A	EIF2B3	chr1	45443987	-	ZBTB5	chr9	37442552	-
103281	UCEC	TCGA-JU-AAVI	ERI3	chr1	44818521	-	EIF2B3	chr1	45392411	-
103281	UCEC	TCGA-JU-AAVI-01A	ERI3	chr1	44818522	-	EIF2B3	chr1	45392411	-
103281	Non-Cancer	215N	ERMAP	chr1	43282924	+	EIF2B3	chr1	45323479	-
103281	N/A	L38434	IGKV1D-39	chr2	89901791	+	EIF2B3	chr1	45431624	-
103281	COAD	TCGA-DM-A285-01A	IPO13	chr1	44426934	+	EIF2B3	chr1	45323479	-
103281	LGG	TCGA-HT-A617-01A	LAMC3	chr9	133928352	-	EIF2B3	chr1	45363116	-
103281	BRCA	TCGA-JL-A3YW-01A	SCMH1	chr1	41578955	-	EIF2B3	chr1	45316675	-
103281	LUAD	TCGA-44-3917-01A	SLC6A9	chr1	44496978	-	EIF2B3	chr1	45363116	-
103281	LUAD	TCGA-44-7660-01A	SZT2	chr1	43898110	+	EIF2B3	chr1	45446849	-
103281	BRCA	TCGA-E9-A1NA-01A	TMEM53	chr1	45125846	-	EIF2B3	chr1	45363116	-
103281	TGCT	TCGA-XY-A8S2-01A	ZNF684	chr1	40998853	+	EIF2B3	chr1	45316675	-
103285	GBM	TCGA-06-0649	ZSWIM5	chr1	45553552	-	EIF2B3	chr1	45392411	-
103285	GBM	TCGA-06-0649-01B	ZSWIM5	chr1	45553553	-	EIF2B3	chr1	45392411	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	EIF2B3	0.00751056217962084	0.2
LUSC	EIF2B3	0.0197152432175715	0.51
SKCM	EIF2B3	0.0215422265703907	0.54
UVM	EIF2B3	0.0357505449169832	0.86
THCA	EIF2B3	0.0381696953181108	0.88
LIHC	EIF2B3	1.38245076837041e-06	3.9e-05

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EIF2B3	0.00291445923301034	0.093
LUSC	EIF2B3	0.0419458589679465	1
KIRP	EIF2B3	0.00319271483067893	0.099
BRCA	EIF2B3	0.0405618692058797	1
OV	EIF2B3	0.00606059591406828	0.18
ESCA	EIF2B3	0.00487860631821873	0.15
BLCA	EIF2B3	0.0152888270550597	0.43
THYM	EIF2B3	0.0304378220464306	0.82
SARC	EIF2B3	0.000955582885428173	0.032

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1858991	Childhood Ataxia with Central Nervous System Hypomyelinization	6	GENOMICS_ENGLAND;ORPHANET;UNIPROT
C1847967	OVARIOLEUKODYSTROPHY	1	CTD_human;ORPHANET