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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL14 (NCBI Gene ID:9045)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL14
	Gene ID: 9045
	Gene Symbol	RPL14
	Gene ID	9045
	Gene Name	ribosomal protein L14
	Synonyms	CAG-ISL-7\|CTG-B33\|L14\|RL14\|hRL14
	Cytomap	3p22.1
	Type of Gene	protein-coding
	Description	60S ribosomal protein L14large ribosomal subunit protein eL14
	Modification date	20200313
	UniProtAcc	P50914

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL14[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL14	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000338970	40502897	40502997	Frame-shift
ENST00000396203	40502897	40502997	Frame-shift
ENST00000338970	40503098	40503152	In-frame
ENST00000396203	40503098	40503152	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000338970	40503098	40503152	872	370	423	215	100	118
ENST00000396203	40503098	40503152	933	433	486	215	100	118

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	RPL14	1.1487848232634	0.00321821289681976
COAD	RPL14	2.38206887570306	6.03199005126954e-05
BRCA	RPL14	-2.51759496082785	6.20044644295049e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	RPL14	1	2	0.0316457248033438	0.14160191588785	0.219424444444444	0.0777864401021074	0.204094747474978
SKCM	RPL14	1	2	0.00813085993025284	0.110289583333333	0.22005125	-0.414589214513698	-0.10533636363606

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SARC	RPL14	-0.113391626	0.027906903

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL14 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL14	SNRPD2	0.831237864	2.60E-13
DLBC	Cell metabolism gene	RPL14	PFDN5	0.835016806	1.61E-13
DLBC	Cell metabolism gene	RPL14	TIMM9	0.843647775	5.17E-14
DLBC	Cell metabolism gene	RPL14	FAU	0.866212811	1.85E-15
DLBC	CGC	RPL14	NACA	0.824008549	6.28E-13
DLBC	Epifactor	RPL14	FBL	0.820718689	9.26E-13
DLBC	TF	RPL14	ZNF444	0.803035161	6.57E-12
DLBC	TSG	RPL14	GNB2L1	0.860279561	4.70E-15
KICH	Cell metabolism gene	RPL14	SNRPD2	0.827341136	5.15E-24
KICH	CGC	RPL14	NACA	0.803118126	1.01E-21
KICH	Epifactor	RPL14	SS18L2	0.804267881	7.99E-22
KIRP	Cell metabolism gene	RPL14	FAU	0.826608752	3.88E-82
KIRP	Epifactor	RPL14	SS18L2	0.823541135	4.96E-81
LGG	Cell metabolism gene	RPL14	FAU	0.837813462	6.86E-141
LIHC	CGC	RPL14	NACA	0.801342424	5.49E-96
LIHC	TSG	RPL14	GNB2L1	0.816758088	1.34E-102
PRAD	Cell metabolism gene	RPL14	NME2	0.80706442	1.73E-127
PRAD	Cell metabolism gene	RPL14	SNRPD2	0.810040895	3.83E-129
PRAD	Cell metabolism gene	RPL14	TIMM9	0.84463125	7.91E-151
PRAD	Cell metabolism gene	RPL14	FAU	0.850169047	8.58E-155
PRAD	CGC	RPL14	NACA	0.892126754	3.05E-191
PRAD	Epifactor	RPL14	FBL	0.816403683	8.77E-133
PRAD	TF	RPL14	NME2	0.80706442	1.73E-127
PRAD	TSG	RPL14	GAS5	0.834468086	6.11E-144
PRAD	TSG	RPL14	GNB2L1	0.884603378	1.09E-183
TGCT	Cell metabolism gene	RPL14	FAU	0.808114681	3.16E-37
TGCT	TSG	RPL14	GADD45GIP1	0.828712189	1.17E-40
THCA	Cell metabolism gene	RPL14	SNRPD2	0.806713256	2.50E-132
THCA	Cell metabolism gene	RPL14	FAU	0.837171707	1.68E-151
THCA	IUPHAR	RPL14	CSNK2B	0.809262102	8.47E-134
THCA	TSG	RPL14	GAS5	0.821373351	4.24E-141
THCA	TSG	RPL14	GNB2L1	0.865813857	1.51E-173
THYM	Cell metabolism gene	RPL14	LSM2	0.80384623	7.62E-29
THYM	Cell metabolism gene	RPL14	PFDN6	0.806220363	3.96E-29
THYM	Cell metabolism gene	RPL14	SNRPD3	0.811234644	9.64E-30
THYM	Cell metabolism gene	RPL14	PGLS	0.821193575	5.12E-31
THYM	Cell metabolism gene	RPL14	POLR2F	0.822758965	3.18E-31
THYM	Cell metabolism gene	RPL14	SLC27A5	0.822810202	3.13E-31
THYM	Cell metabolism gene	RPL14	SSR2	0.823235668	2.74E-31
THYM	Cell metabolism gene	RPL14	SNRPD2	0.839775794	1.27E-33
THYM	Cell metabolism gene	RPL14	TIMM8B	0.846935068	1.03E-34
THYM	Cell metabolism gene	RPL14	PFDN5	0.874105375	1.94E-39
THYM	Cell metabolism gene	RPL14	FAU	0.936504683	1.88E-56
THYM	Epifactor	RPL14	ZNHIT1	0.806358225	3.81E-29
THYM	Epifactor	RPL14	DMAP1	0.81007183	1.34E-29
THYM	Epifactor	RPL14	SIRT6	0.814790711	3.45E-30
THYM	Epifactor	RPL14	BRMS1	0.81719861	1.70E-30
THYM	Epifactor	RPL14	FBL	0.828618992	5.09E-32
THYM	Epifactor	RPL14	CCDC101	0.834241872	8.21E-33
THYM	Epifactor	RPL14	INO80E	0.838030363	2.31E-33
THYM	Epifactor	RPL14	SS18L2	0.861027339	4.85E-37
THYM	Epifactor	RPL14	TAF10	0.874436876	1.67E-39
THYM	IUPHAR	RPL14	SIRT6	0.814790711	3.45E-30
THYM	IUPHAR	RPL14	SLC27A5	0.822810202	3.13E-31
THYM	TF	RPL14	ZNF428	0.81925297	9.21E-31
THYM	TSG	RPL14	AIP	0.801576772	1.41E-28
THYM	TSG	RPL14	GADD45GIP1	0.80396387	7.38E-29
THYM	TSG	RPL14	SIRT6	0.814790711	3.45E-30
THYM	TSG	RPL14	NPRL2	0.816674842	1.98E-30
THYM	TSG	RPL14	BRMS1	0.81719861	1.70E-30
THYM	TSG	RPL14	GLTSCR2	0.872951994	3.23E-39
THYM	TSG	RPL14	GNB2L1	0.875078733	1.25E-39
UCS	Cell metabolism gene	RPL14	LSM2	0.80384623	7.62E-29
UCS	Cell metabolism gene	RPL14	PFDN6	0.806220363	3.96E-29
UCS	Cell metabolism gene	RPL14	SNRPD3	0.811234644	9.64E-30
UCS	Cell metabolism gene	RPL14	PGLS	0.821193575	5.12E-31
UCS	Cell metabolism gene	RPL14	POLR2F	0.822758965	3.18E-31
UCS	Cell metabolism gene	RPL14	SLC27A5	0.822810202	3.13E-31
UCS	Cell metabolism gene	RPL14	SSR2	0.823235668	2.74E-31
UCS	Cell metabolism gene	RPL14	SNRPD2	0.839775794	1.27E-33
UCS	Cell metabolism gene	RPL14	TIMM8B	0.846935068	1.03E-34
UCS	Cell metabolism gene	RPL14	PFDN5	0.874105375	1.94E-39
UCS	Cell metabolism gene	RPL14	FAU	0.936504683	1.88E-56
UCS	Epifactor	RPL14	ZNHIT1	0.806358225	3.81E-29
UCS	Epifactor	RPL14	DMAP1	0.81007183	1.34E-29
UCS	Epifactor	RPL14	SIRT6	0.814790711	3.45E-30
UCS	Epifactor	RPL14	BRMS1	0.81719861	1.70E-30
UCS	Epifactor	RPL14	FBL	0.828618992	5.09E-32
UCS	Epifactor	RPL14	CCDC101	0.834241872	8.21E-33
UCS	Epifactor	RPL14	INO80E	0.838030363	2.31E-33
UCS	Epifactor	RPL14	SS18L2	0.861027339	4.85E-37
UCS	Epifactor	RPL14	TAF10	0.874436876	1.67E-39
UCS	IUPHAR	RPL14	SIRT6	0.814790711	3.45E-30
UCS	IUPHAR	RPL14	SLC27A5	0.822810202	3.13E-31
UCS	TF	RPL14	ZNF428	0.81925297	9.21E-31
UCS	TSG	RPL14	AIP	0.801576772	1.41E-28
UCS	TSG	RPL14	GADD45GIP1	0.80396387	7.38E-29
UCS	TSG	RPL14	SIRT6	0.814790711	3.45E-30
UCS	TSG	RPL14	NPRL2	0.816674842	1.98E-30
UCS	TSG	RPL14	BRMS1	0.81719861	1.70E-30
UCS	TSG	RPL14	GLTSCR2	0.872951994	3.23E-39
UCS	TSG	RPL14	GNB2L1	0.875078733	1.25E-39
UVM	Cell metabolism gene	RPL14	LTA4H	0.830886989	1.50E-21
UVM	Epifactor	RPL14	FBL	0.834976377	6.26E-22
UVM	IUPHAR	RPL14	LTA4H	0.830886989	1.50E-21
UVM	TSG	RPL14	ST13	0.826800681	3.50E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL14	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL14	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL14	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL14	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL14	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL14	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL14	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL14	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL14	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL14	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL14	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL14	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL14	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL14	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL14	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL14	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL14	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL14	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL14	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL14	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL14	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL14	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL14	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL14	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL14	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL14	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL14	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL14	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL14

PHLDA1, NOP56, STAU1, PTEN, KLF10, PCK1, VHL, ARRB2, SIRT7, TCF3, CUL3, CUL4B, CUL2, CDK2, CUL1, COPS5, CAND1, RPL10A, RPL11, RPL12, RPL13, RPL15, RPL18A, RPL19, RPL21, RPL23A, RPL24, RPL27, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL9, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS17, RPS19, RPS23, RPS24, RPS2, RPS3A, RPS3, RPS4X, RPS6, RPS8, RPSA, RPL18, RPL8, RPS26, RPS25, RPL31, RPL22, RPS20, RPL23, RPS5, RPL10, RPS28, RPLP2, RPLP0, RPL27A, RPL30, RPS10, RPL36, RPS7, RPL35, RPL38, RPL17, RPL32, RPS21, RPL29, RPS27A, EEF2, ILF3, NCL, NPM1, SRP14, SLC25A5, ILF2, HSP90AB1, HNRNPM, TUFM, NAP1L1, ACTA2, RPS27L, RPL10L, RPLP0P6, CDH2, UQCRB, NENF, ICT1, RPS10P5, MRPL12, PTGES3, ESR1, FN1, VCAM1, UBL4A, ITGA4, PAN2, KCNK4, TLE6, TARDBP, PARP1, G3BP1, KRT18, ZBTB1, GRSF1, CEP250, TP53, TUBG1, TUBGCP4, FUS, PEX5, CUL7, OBSL1, CCDC8, EED, RNF2, EBNA1BP2, NOL12, CCDC137, RBM28, SRRM1, FTSJ3, PRPF4B, VPRBP, DDX21, MYEF2, ZNF768, ZNF629, ZNF668, ZKSCAN8, TAF1A, ZNF512, DKC1, STAU2, DDX56, URB2, DDX27, DDX52, CEBPZ, ZSCAN25, HP1BP3, REXO4, MYBBP1A, RPL26L1, DDX24, RRP8, C8orf33, RSBN1L, TTF1, ZFP62, SCAF1, SURF6, PAK1IP1, KIAA0020, RRP1B, RBMX2, NVL, RPL36AL, GLTSCR2, URB1, LLPH, NIFK, WHSC1, RBM34, NOC3L, NOP2, DDX54, BUD13, TRAF4, HERC5, BRIX1, ZBTB24, RRS1, GNL2, ZNF770, DDX31, RBM5, CDK12, FYTTD1, RPL13A, RPF1, TAF1D, GTPBP4, RPF2, ARGLU1, GZF1, ZNF22, C9orf114, PPAN-P2RY11, ZCCHC7, TAF1C, MINA, RPS6KB2, NTRK1, GNL3, NDUFS4, PABPC1, REV3L, RPL26, RPL34, RPL3L, RPLP1, RPS9, SCD, RPL28, RPL35A, RPS14, RPS15, RPS18, LOC101929876, RPS27, SSR3, BLM, HIST1H3E, FOSL2, Eif3a, Srp72, Rrbp1, SKI, NF2, ZNF746, CDH1, EGFR, CNBP, RBM4, PPIG, ZNF526, CYLD, TRIM25, BRCA1, YAP1, MTF1, CFTR, FBXO7, PPP1CC, BMP4, PCBP1, IQGAP1, MATN2, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, FAM188B, RIOK1, HEXIM1, MEPCE, LARP7, SNAI1, AGR2, RECQL4, GPC1, REST, MYC, GRWD1, KRT17, METTL14, EIF4B, RC3H1, RC3H2, ACTC1, PHB, KIN, NR2C2, HDAC2, CTCF, VRK1, VRK3, HIST1H4A, APEX1, SLC15A3, SNRNP70, Dppa3, ITFG1, HMGB1, BIRC3, WWP2, BRD7, MATR3, Dnajc17, TEX101, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, HCVgp1, ZC3H18, GRB7, MAP3K14, PRKD1, PTPN6, PPA1, C1orf116, TET3, CDH16, KIAA0754, AHNAK, BST2, SPATA31E1, BAIAP2, SLCO6A1, HIST1H1E, HIST1H2BH, SNIP1, N, nsp2, nsp6, ORF7b, SMC3, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, MAD2L2, KIF20A, KIF23, PRC1, LDLR, NMRAL1, BRD4, Apc2, RBM39, FBP1, LGALS9, RIN3, DNAJC25, DNAJC2, KDF1, PARK2, UFL1, DDRGK1, EIF6, LRRC59, PTK2, TRIM37, FZR1, WDR5, PAGE4, NUDCD2, NAA40, ZC3H10, PRKRA, CCDC140, ADARB1, TRIM56, PAPD5, KNOP1, BOP1, NIP7, DHX8, APOBEC3C, IMP4, ZNF574, C14orf169, MAK16, RPL7L1, ZNF16, ABT1, NSA2, YTHDC2, UTP3, RRP1, RPS4Y2, LUC7L, ZFP91, DDX18, RRP15, OASL, SRP68, DDX10, C7orf50, NOP16, CHTOP, NLE1, HIST1H1T, SPATS2L, EPB41L5, PURA, MPHOSPH10, EPB41L4B, ZC3HAV1, RSL24D1, ZNF346, ZNF771, FAM111A, MAGEB2, GPATCH4, DHX30, NKRF, NOM1, SRPK2, XRN1, RSBN1, IMP3, HIST2H2AB, GLYR1, BTF3, SLFN11, EP300, FBXW7, UBR5, ALG13, NLRP7, RCHY1, CCNF, TMEM192, RB1CC1, KLF4, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL14	chr3	40503520	A	ACTGCTGCTGCTGCTG	Microsatellite	Benign	not_provided	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
RPL14	chr3	40503520	A	ACTGCTGCTGCTGCTGCTG	Microsatellite	Benign	not_provided	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL14	BRCA	chr3	40503520	40503521	-	CTGCTG	In_Frame_Ins	p.153in_frame_insAA	6
RPL14	UCEC	chr3	40503520	40503521	-	CTG	In_Frame_Ins	p.153in_frame_insA	4
RPL14	LIHC	chr3	40503685	40503685	A	-	Frame_Shift_Del	p.K204fs	3
RPL14	PAAD	chr3	40503613	40503613	G	A	Missense_Mutation	p.A180T	3
RPL14	COAD	chr3	40503520	40503520	A	G	Missense_Mutation	p.T149A	3
RPL14	UCEC	chr3	40499048	40499048	C	G	Missense_Mutation	p.A29G	2
RPL14	KIRP	chr3	40503557	40503557	T	C	Missense_Mutation	p.V161A	2
RPL14	UCEC	chr3	40499409	40499409	G	T	Missense_Mutation	p.R11L	2
RPL14	LIHC	chr3	40503651	40503651	A	-	Frame_Shift_Del	p.P192fs	2
RPL14	UCEC	chr3	40503520	40503521	-	CTGCTGCTG	In_Frame_Ins	p.153in_frame_insAAA	2
RPL14	UCEC	chr3	40503638	40503638	C	T	Missense_Mutation	p.A188V	2
RPL14	PAAD	chr3	40503613	40503613	G	A	Missense_Mutation		2
RPL14	COAD	chr3	40503520	40503521	-	CTGCTGCTGCTGCTG	In_Frame_Ins	p.T149delinsTAAAAA	2
RPL14	SKCM	chr3	40503518	40503518	G	C	Missense_Mutation	p.G148A	2
RPL14	GBM	chr3	40499407	40499407	C	T	Silent	p.G10G	1
RPL14	LUSC	chr3	40503622	40503622	G	A	Missense_Mutation	p.A183T	1
RPL14	SKCM	chr3	40503630	40503630	C	T	Silent	p.G185G	1
RPL14	MESO	chr3	40503518	40503518	G	C	Missense_Mutation		1
RPL14	CESC	chr3	40503459	40503459	G	A	Silent		1
RPL14	SKCM	chr3	40503610	40503610	C	T	Missense_Mutation	p.P179S	1
RPL14	LIHC	chr3	40503563	40503564	-	-	Frame_Shift_Ins		1
RPL14	OV	chr3	40478524	40478525	-	CTGCTG	In_Frame_Ins	p.153in_frame_insAA	1
RPL14	CESC	chr3	40503459	40503459	G	A	Silent	p.K128	1
RPL14	STAD	chr3	40503441	40503441	A	G	Missense_Mutation	p.I122M	1
RPL14	PAAD	chr3	40503123	40503123	C	A	Missense_Mutation		1
RPL14	COAD	chr3	40499433	40499433	C	A	Missense_Mutation	p.P19H	1
RPL14	STAD	chr3	40499484	40499484	T	C	Splice_Site	p.R35_splice	1
RPL14	COAD	chr3	40502923	40502923	G	A	Missense_Mutation	p.A76T	1
RPL14	STAD	chr3	40500174	40500174	C	A	Silent	p.A49A	1
RPL14	LIHC	chr3	40499466	40499466	T	-	Frame_Shift_Del	p.V30fs	1
RPL14	PAAD	chr3	40503537	40503538	-	GCTGCTGCTGCTGCT	In_Frame_Ins	p.A154delinsAAAAAA	1
RPL14	COAD	chr3	40503141	40503141	G	C	Missense_Mutation	p.A115P	1
RPL14	THYM	chr3	40499481	40499481	G	T	Missense_Mutation		1
RPL14	LIHC	chr3	40500217	40500217	T	-	Frame_Shift_Del	p.F64fs	1
RPL14	THYM	chr3	40503432	40503432	G	T	Missense_Mutation	p.R119S	1
RPL14	LUAD	chr3	40499405	40499405	G	T	Missense_Mutation	p.G10C	1
RPL14	SARC	chr3	40502907	40502907	G	T	Missense_Mutation		1
RPL14	THYM	chr3	40499481	40499481	G	T	Missense_Mutation	p.R35M	1
RPL14	LUAD	chr3	40503438	40503438	A	G	Missense_Mutation	p.N121D	1
RPL14	SARC	chr3	40502935	40502935	G	A	Missense_Mutation	p.A80T	1
RPL14	COAD	chr3	40503582	40503582	G	A	Silent	p.A169A	1
RPL14	THYM	chr3	40502965	40502965	C	T	Nonsense_Mutation	p.R90X	1
RPL14	LUAD	chr3	40502966	40502966	G	A	Missense_Mutation	p.R90Q	1
RPL14	BLCA	chr3	40500162	40500162	G	A	Silent		1
RPL14	ESCA	chr3	40500165	40500165	G	T	Missense_Mutation	p.R46S	1
RPL14	THYM	chr3	40503432	40503432	G	T	Missense_Mutation		1
RPL14	LUAD	chr3	40503438	40503438	A	G	Silent	p.R121R	1
RPL14	BLCA	chr3	40500162	40500162	G	A	Silent	p.V45V	1
RPL14	SKCM	chr3	40503631	40503631	C	T	Nonsense_Mutation	p.Q186*	1

Copy number variation (CNV) of RPL14
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL14
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102577	LUSC	TCGA-37-3789	CENPT	chr16	67876834	-	RPL14	chr3	40503553	+
102577	UCEC	TCGA-D1-A162-01A	CENPT	chr16	67876840	-	RPL14	chr3	40503553	+
102577	Non-Cancer	ERR188192	E2F4	chr16	67229785	+	RPL14	chr3	40503545	+
102577	Non-Cancer	ERR188353	E2F4	chr16	67229791	+	RPL14	chr3	40503548	+
102577	Non-Cancer	ERR188391	E2F4	chr16	67229785	+	RPL14	chr3	40503542	+
102577	Non-Cancer	TCGA-AX-A1CK-11A	E2F4	chr16	67229791	+	RPL14	chr3	40503545	+
102577	N/A	BC010079	E2F4	chr16	67229791	+	RPL14	chr3	40503542	+
102577	LUAD	TCGA-78-7539-01A	GLS	chr2	191745591	+	RPL14	chr3	40503542	+
102577	N/A	AA737352	HIC2	chr22	21786964	-	RPL14	chr3	40503859	-
102577	N/A	DN913418	IL21-AS1	chr4	123590560	-	RPL14	chr3	40503856	-
102577	N/A	BI963092	JHDM1D-AS1	chr7	139877292	+	RPL14	chr3	40507590	+
102577	BLCA	TCGA-DK-A3X1-01A	LRP8	chr1	53793534	-	RPL14	chr3	40503521	+
102577	BLCA	TCGA-KQ-A41O-01A	LRP8	chr1	53793512	-	RPL14	chr3	40503543	+
102577	PRAD	TCGA-CH-5772-01A	MED12	chrX	70361136	+	RPL14	chr3	40503560	+
102577	CESC	TCGA-C5-A2LX-01A	MIR205HG	chr1	209606052	+	RPL14	chr3	40503099	+
102577	CESC	TCGA-EK-A2PM-01A	MIR205HG	chr1	209605674	+	RPL14	chr3	40503560	+
102577	CESC	TCGA-EK-A2RC-01A	MIR205HG	chr1	209605675	+	RPL14	chr3	40503555	+
102577	N/A	BC051312	NCOR2	chr12	124904505	-	RPL14	chr3	40503539	+
102577	N/A	AA650162	PCP4	chr21	41275797	-	RPL14	chr3	40503765	-
102577	N/A	EC565665	PPM1B	chr2	44470395	-	RPL14	chr3	40503123	+
75963	N/A	BE772607	RPL14	chr3	40503521	-	ARHGEF3	chr3	56823099	-
101719	STAD	TCGA-CG-5721-01A	RPL14	chr3	40498965	+	ARIH2	chr3	48960181	+
90783	N/A	CB331945	RPL14	chr3	40503767	+	CHSY3	chr5	129464654	-
97127	READ	TCGA-AG-3584	RPL14	chr3	40503522	+	E2F4	chr16	67229814	+
77258	N/A	BF127989	RPL14	chr3	40503476	+	MED12	chrX	70360659	+
77258	N/A	BG519661	RPL14	chr3	40503641	+	MED12	chrX	70361761	+
75963	N/A	AA912468	RPL14	chr3	40503696	-	MRPL23	chr11	2018434	+
97166	N/A	AA532996	RPL14	chr3	40503547	+	NUP93	chr16	56849802	+
97166	N/A	BQ003432	RPL14	chr3	40503541	-	NUP93	chr16	56849774	+
102577	N/A	AV738739	RPL14	chr3	40503739	+	RPL14	chr3	40502898	+
87452	N/A	BU630143	RPL14	chr3	40503534	-	S100A16	chr1	153579639	+
97247	N/A	CD240407	RPL14	chr3	40503761	+	SCOC	chr4	141287434	+
102333	N/A	BP334301	RPL14	chr3	40503146	+	SENP6	chr6	76411705	+
94405	STAD	TCGA-BR-7723-01A	RPL14	chr3	40503505	+	SRP14	chr15	40328595	-
94405	UCEC	TCGA-E6-A1M0-01A	RPL14	chr3	40503471	+	SRP14	chr15	40328611	-
75963	COAD	TCGA-AZ-4681-01A	RPL14	chr3	40499447	+	YIPF6	chrX	67718628	+
102577	COAD	TCGA-AA-3994-01A	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
102577	COAD	TCGA-CM-4743-01A	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
102577	READ	TCGA-AG-3594	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
102577	READ	TCGA-AG-4005	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
102577	STAD	TCGA-BR-4267-01A	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
102577	STAD	TCGA-BR-4267-01A	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
102577	UCEC	TCGA-D1-A167-01A	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
102577	N/A	AA515951	SYN3	chr22	33371357	-	RPL14	chr3	40503859	-
102577	Non-Cancer	TCGA-CG-5720-11A	ZNF620	chr3	40547867	+	RPL14	chr3	40502898	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL14	0.00135983873666407	0.038
HNSC	RPL14	0.0318355326012479	0.86
STAD	RPL14	0.0467325176396705	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL14	0.00808524500471418	0.27
PAAD	RPL14	0.0169478503831172	0.54
BLCA	RPL14	0.0407013920645927	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0007134	Renal Cell Carcinoma	1	CTD_human
C0030567	Parkinson Disease	1	CTD_human
C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
C1306837	Papillary Renal Cell Carcinoma	1	CTD_human