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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL23 (NCBI Gene ID:9349)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL23
	Gene ID: 9349
	Gene Symbol	RPL23
	Gene ID	9349
	Gene Name	ribosomal protein L23
	Synonyms	L23\|rpL17
	Cytomap	17q12
	Type of Gene	protein-coding
	Description	60S ribosomal protein L2360S ribosomal protein L17large ribosomal subunit protein uL14ribosomal protein L17
	Modification date	20200313
	UniProtAcc	P62829

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL23	GO:0032986	protein-DNA complex disassembly	19160485
Hgene	RPL23	GO:1904667	negative regulation of ubiquitin protein ligase activity	15314173
Hgene	RPL23	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	15314173

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL23	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL23[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL23	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000394332	37006369	37006467	5CDS-5UTR
ENST00000394332	37006614	37006728	In-frame
ENST00000479035	37006614	37006728	In-frame
ENST00000394332	37008856	37008985	In-frame
ENST00000479035	37008856	37008985	In-frame
ENST00000479035	37009274	37009358	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000394332	37006614	37006728	642	239	352	140	75	113
ENST00000479035	37006614	37006728	2838	360	473	140	75	113
ENST00000394332	37008856	37008985	642	110	238	140	32	75
ENST00000479035	37008856	37008985	2838	231	359	140	32	75
ENST00000479035	37009274	37009358	2838	147	230	140	4	32

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62829	75	113	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
P62829	32	75	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
P62829	75	113	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
P62829	32	75	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
P62829	4	32	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
P62829	4	32	17	17	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18691976;Dbxref=PMID:18691976
P62829	32	75	38	38	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:15592455;Dbxref=PMID:15592455
P62829	32	75	38	38	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:15592455;Dbxref=PMID:15592455
P62829	75	113	77	77	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P62829	75	113	77	77	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	RPL23	-3.65655157280645	0.0157928575534704
KIRP	RPL23	-3.16602228862164	2.00420618057251e-06
KIRC	RPL23	-4.40036780721891	6.64395189280361e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	RPL23	-0.091767503	0.007533759

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL23 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPL23	SNRPD2	0.818015719	6.88E-12
CHOL	CGC	RPL23	NACA	0.81070382	1.48E-11
CHOL	Epifactor	RPL23	FBL	0.81552659	8.97E-12
DLBC	Cell metabolism gene	RPL23	POLR2J	0.809474711	3.30E-12
DLBC	Cell metabolism gene	RPL23	TOMM22	0.81276206	2.29E-12
DLBC	Cell metabolism gene	RPL23	POLR2F	0.814652831	1.86E-12
DLBC	Cell metabolism gene	RPL23	PFDN5	0.839120669	9.47E-14
DLBC	Cell metabolism gene	RPL23	SNRPD2	0.852381216	1.52E-14
DLBC	Cell metabolism gene	RPL23	NME2	0.85437272	1.14E-14
DLBC	Cell metabolism gene	RPL23	TIMM9	0.859297956	5.46E-15
DLBC	Cell metabolism gene	RPL23	FAU	0.873777869	5.28E-16
DLBC	CGC	RPL23	NACA	0.924802368	6.23E-21
DLBC	Epifactor	RPL23	FBL	0.821988138	7.98E-13
DLBC	TF	RPL23	THAP4	0.810284026	3.02E-12
DLBC	TF	RPL23	ZNF581	0.827745899	4.00E-13
DLBC	TF	RPL23	NME2	0.85437272	1.14E-14
DLBC	TSG	RPL23	GADD45GIP1	0.80041391	8.64E-12
DLBC	TSG	RPL23	GNB2L1	0.923866745	8.19E-21
KICH	TSG	RPL23	GAS5	0.826197837	6.73E-24
KIRP	Cell metabolism gene	RPL23	SNRPD2	0.808510314	6.67E-76
KIRP	Cell metabolism gene	RPL23	NME2	0.811998241	4.74E-77
KIRP	TF	RPL23	NME2	0.811998241	4.74E-77
LGG	Cell metabolism gene	RPL23	FAU	0.848419561	5.45E-148
LGG	CGC	RPL23	NACA	0.809076461	5.59E-124
LGG	TSG	RPL23	GAS5	0.80769535	3.07E-123
LGG	TSG	RPL23	GNB2L1	0.849158364	1.67E-148
PRAD	Cell metabolism gene	RPL23	FAU	0.803467747	1.59E-125
PRAD	Cell metabolism gene	RPL23	TIMM9	0.818303561	6.74E-134
PRAD	CGC	RPL23	NACA	0.848251681	2.11E-153
PRAD	Epifactor	RPL23	FBL	0.823622431	4.34E-137
PRAD	TSG	RPL23	GAS5	0.839867771	1.54E-147
PRAD	TSG	RPL23	GNB2L1	0.85920133	1.29E-161
THCA	Cell metabolism gene	RPL23	SNRPD2	0.805673658	9.79E-132
THCA	Cell metabolism gene	RPL23	FAU	0.811768551	2.89E-135
THYM	Cell metabolism gene	RPL23	SLC27A5	0.808943693	1.85E-29
THYM	Cell metabolism gene	RPL23	TIMM8B	0.809852107	1.43E-29
THYM	Cell metabolism gene	RPL23	SNRPD2	0.810158274	1.31E-29
THYM	Cell metabolism gene	RPL23	SSR2	0.8285013	5.28E-32
THYM	Cell metabolism gene	RPL23	PFDN5	0.857791923	1.75E-36
THYM	Cell metabolism gene	RPL23	FAU	0.879524521	1.63E-40
THYM	Epifactor	RPL23	FBL	0.83738045	2.88E-33
THYM	IUPHAR	RPL23	SLC27A5	0.808943693	1.85E-29
THYM	TSG	RPL23	GLTSCR2	0.803676103	7.99E-29
THYM	TSG	RPL23	GNB2L1	0.848355257	6.14E-35
UCS	Cell metabolism gene	RPL23	SLC27A5	0.808943693	1.85E-29
UCS	Cell metabolism gene	RPL23	TIMM8B	0.809852107	1.43E-29
UCS	Cell metabolism gene	RPL23	SNRPD2	0.810158274	1.31E-29
UCS	Cell metabolism gene	RPL23	SSR2	0.8285013	5.28E-32
UCS	Cell metabolism gene	RPL23	PFDN5	0.857791923	1.75E-36
UCS	Cell metabolism gene	RPL23	FAU	0.879524521	1.63E-40
UCS	Epifactor	RPL23	FBL	0.83738045	2.88E-33
UCS	IUPHAR	RPL23	SLC27A5	0.808943693	1.85E-29
UCS	TSG	RPL23	GLTSCR2	0.803676103	7.99E-29
UCS	TSG	RPL23	GNB2L1	0.848355257	6.14E-35
UVM	Cell metabolism gene	RPL23	POLR1D	0.803408593	3.04E-19
UVM	CGC	RPL23	NACA	0.862229336	9.45E-25
UVM	TSG	RPL23	GLTSCR2	0.826077957	4.06E-21
UVM	TSG	RPL23	GAS5	0.826935473	3.40E-21
UVM	TSG	RPL23	GNB2L1	0.834624837	6.75E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL23	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL23	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL23	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL23	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL23	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL23	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL23	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL23	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL23	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL23	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL23	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL23	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL23	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL23	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL23	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL23	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL23	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL23	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL23	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL23	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL23	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL23	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL23	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL23	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL23	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL23	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL23	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL23	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL23

BCCIP, CDC42, MDM2, RPL11, RPL5, TP53, AGO4, DCC, NOP56, EBNA-LP, MTOR, RICTOR, MAPKAP1, PCK1, RAD21, CUL3, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, LRRK2, CRK, APP, RPS6, RPL10A, RPL12, RPL13, RPL15, RPL18A, RPL18, RPL19, RPL23A, RPL24, RPL27, RPL31, RPL37A, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS15A, RPS16, RPS23, RPS28, RPS8, RPSA, RPS13, RPL4, RPS14, RPS2, RPS12, RPL21, RPS24, RPS4X, RPLP2, RPL14, RPS3, RPS19, RPS26, RPS20, RPL30, RPL3, RPS17, RPS7, RPS5, RPLP0, RPS11, RPL10, RPS3A, RPS25, RPLP1, RPL22, RPS21, RPL17, RPL32, RPS27A, EEF2, ILF2, GNL3, ILF3, SLC25A5, FBL, TUFM, NHP2L1, HNRNPM, EIF6, RPS27L, NOP2, RPLP0P6, RPL10L, NIFK, UQCRB, MRPL23, MRPS14, MRPS11, RRS1, NACA2, MRPL12, SMURF1, FN1, VCAM1, NOS2, gag-pol, UBL4A, ITGA4, RL1, PAN2, EPS8L2, DAPP1, CLU, RELA, FBXO6, TARDBP, ASS1, ATG3, CNDP2, DLD, PDIA3, SLC9A3R1, SMEK2, USP14, rev, ASB14, ASB17, HSPA5, AURKA, CDC20, CEP250, CEP57, CEP76, LGALS3BP, TUBG1, TUBGCP3, VCP, HUWE1, CUL7, EED, EGFR, FAM187B, HLA-DPA1, COLEC11, ASGR2, DNASE1L2, ANTXR1, TMEM25, TSSC1, CBWD1, ITGB8, PSMC3, THBS3, APRT, BRIX1, DDX27, MRPS5, NDUFS4, RNPS1, RPL13A, DDX18, DDX55, PES1, RPL34, RPS10, RPL26, RPL26L1, RPL27A, RPL28, RPL35, RPL35A, RPL36, RPL38, RPL39, RPL3L, RPS15, RPS18, LOC101929876, RPS27, RPS9, PTEN, AHSA1, DAXX, HNRNPU, Eif3e, Rpl35, Srp72, Rrbp1, Bag2, Spire2, MCM2, Ksr1, ERBB3, ESRRB, RC3H1, NFATC2, ZNF746, PCDHB11, PCDHA10, SSSCA1, PCDH20, EPHA7, PCDHGA5, CRP, PCDHAC2, PCDHA12, EVL, PCDHGB4, PCDH12, AARSD1, PCDHGB1, TOR1AIP2, PCDHB16, PCDHB5, EMILIN1, TUBB, PCDHAC1, CD79A, FSTL4, DYNC1I1, LOXL3, LRP1, FKBP9, MUC20, CDH13, NPM1, NCL, CYLD, UBE2A, HEY1, BRCA1, ARL2, COPE, EIF3D, GEMIN4, GTF2E1, MED23, NDUFB1, NEMF, NOL8, PRMT5, PSMD1, PWP1, ROMO1, RPL23, FBXO7, ACO2, WDR77, API5, BMP4, CTNNB1, DIMT1, MATN2, PCBP1, PPIE, TRIP4, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, CHD4, LARP7, RNF31, TNF, SPDL1, RIOK1, HEXIM1, MEPCE, AGR2, RECQL4, REST, MYC, CDK9, Prkaa1, Prkab1, GRWD1, METTL3, METTL14, KIAA1429, RC3H2, ACTC1, ESR2, PHB, NR2C2, PPP1CC, CTCF, PRMT7, ATXN3, VRK1, HIST1H4A, SNRNP70, ITFG1, ARAF, BIRC3, NFX1, WWP2, TRIM28, CMTR1, MEOX2, ARIH2, PLEKHA4, YAP1, TFCP2, FANCD2, HCVgp1, ZC3H18, FGR, MAP3K14, VAV1, HIST3H3, ANKRD55, E, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, S, NXF1, DUX4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, MAD2L2, KIF20A, KIF23, PRC1, VWA8, EXD2, LRRC59, INS, NDN, CIC, Apc2, RBM39, FBP1, LGALS9, RIN3, BAG5, SPOP, AR, PARK2, UFL1, DDRGK1, TRIM37, NFKBIA, FZR1, PAGE4, NUDCD2, NAA40, PCDHB6, LY86, PCDHGB5, CSNK1G3, CLSTN2, PCDHGA9, LSS, PCDHGA6, CELSR2, CCL3, SPOCK2, HLA-DRA, KCTD12, SEZ6, TUBB4B, NEXN, UBE2O, PAEP, PPP1R9A, ACTA2, COL6A2, C1QTNF7, AIM1L, FAT4, CALM1, S100B, C3orf52, C7orf34, KLHL7, PCDHA8, PSME1, DNAJA2, CBWD2, LAMTOR5, CLSTN1, CDH23, SCGB2A2, PCDH10, MSMB, LURAP1, TMOD2, CDH16, PCDHGA7, LIMA1, C1orf54, HFE, PCDHA11, PCDHGC4, PYCRL, CAPN2, ST14, PCDHGA4, FAT3, DBH, PCDHGC5, NOTCH2, CDH5, PCDHB7, DNASE1L1, OIT3, PCDHB3, PDGFRA, GAA, BTNL2, TUBB2A, CDHR4, ISLR, RAMP3, PPM1M, SPRTN, BTF3, FSCN1, SNRPA, Ddx39, Pef1, RCHY1, CCNF, TAX1BP1, N, PSMD9, BRD4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL23	BLCA	chr17	37008985	37008985	C	T	Missense_Mutation		3
RPL23	LIHC	chr17	37008859	37008859	T	-	Frame_Shift_Del	p.K75fs	3
RPL23	ESCA	chr17	37008985	37008985	C	G	Missense_Mutation	p.G33A	2
RPL23	THCA	chr17	37009327	37009327	C	G	Silent	p.R15R	2
RPL23	HNSC	chr17	37008939	37008939	C	T	Silent	p.R48R	2
RPL23	HNSC	chr17	37009953	37009953	C	G	Missense_Mutation	p.R4P	2
RPL23	UCEC	chr17	37008870	37008870	C	A	Missense_Mutation	p.E71D	2
RPL23	LGG	chr17	37006642	37006642	T	C	Missense_Mutation	p.I105V	2
RPL23	STAD	chr17	37009328	37009328	C	T	Missense_Mutation	p.R15Q	2
RPL23	THCA	chr17	37009327	37009327	C	G	Silent		1
RPL23	BLCA	chr17	37006686	37006686	C	G	Missense_Mutation		1
RPL23	ESCA	chr17	37008985	37008985	C	G	Splice_Site	p.G33_splice	1
RPL23	BLCA	chr17	37006707	37006707	C	A	Missense_Mutation		1
RPL23	HNSC	chr17	37008939	37008939	C	T	Silent		1
RPL23	THYM	chr17	37006676	37006676	G	T	Silent	p.G93G	1
RPL23	BLCA	chr17	37008912	37008912	C	A	Silent		1
RPL23	HNSC	chr17	37009953	37009953	C	G	Missense_Mutation		1
RPL23	UCEC	chr17	37006457	37006457	A	G	Silent	p.I117I	1
RPL23	BLCA	chr17	37008985	37008985	C	T	Splice_Site	p.G33E	1
RPL23	UCEC	chr17	37008911	37008911	C	A	Missense_Mutation	p.G58C	1
RPL23	BLCA	chr17	37006686	37006686	C	G	Missense_Mutation	p.R90T	1
RPL23	BLCA	chr17	37008912	37008912	C	A	Silent	p.V57V	1
RPL23	BLCA	chr17	37008873	37008892	TGGTTTGCCTTTCTTGACTG	-	Frame_Shift_Del	p.TVKKGKP64fs	1
RPL23	LGG	chr17	37006642	37006642	T	C	Missense_Mutation		1
RPL23	BLCA	chr17	37008873	37008892	TGGTTTGCCTTTCTTGACTG	-	Frame_Shift_Del	p.T64fs	1
RPL23	LIHC	chr17	37009728	37009745	GCGGTATCCAGACTACAT	-	Splice_Site		1
RPL23	ACC	chr17	37010038	37010038	C	T	Translation_Start_Site		1
RPL23	CESC	chr17	37009982	37009982	G	C	Missense_Mutation		1
RPL23	BLCA	chr17	37008873	37008892	TGGTTTGCCTTTCTTGACTG	-	Frame_Shift_Del		1
RPL23	COAD	chr17	37006411	37006411	C	T	Missense_Mutation	p.A133T	1

Copy number variation (CNV) of RPL23
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Fusion gene breakpoints (product of the structural variants (SVs)) across RPL23
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
80746	N/A	CB050317	ANO3	chr11	26294794	+	RPL23	chr17	37006334	+
80746	UCEC	TCGA-DI-A2QT-01A	APLP2	chr11	129999097	+	RPL23	chr17	37006652	-
80746	ACC	TCGA-OR-A5KX-01A	ARHGAP23	chr17	36638919	+	RPL23	chr17	37009358	-
80746	N/A	EC574239	ARHGAP23	chr17	36662177	-	RPL23	chr17	37009992	-
80746	N/A	BQ311440	C5orf24	chr5	134190759	+	RPL23	chr17	37008882	-
80746	N/A	AA045738	CBR4	chr4	169849369	-	RPL23	chr17	37006699	-
80746	N/A	BF511641	CPNE1	chr20	34215903	-	RPL23	chr17	37006334	+
80746	N/A	BI492920	CTC-326K19.6	chr19	50442677	-	RPL23	chr17	37006334	+
80746	BRCA	TCGA-D8-A1XJ-01A	FBXL20	chr17	37557614	-	RPL23	chr17	37009358	-
80746	N/A	DW440511	GAPDH	chr12	6646535	+	RPL23	chr17	37009979	-
80746	N/A	CF124298	HMGB1	chr13	31165666	+	RPL23	chr17	37009988	-
80746	HNSC	TCGA-CV-5443	IGKC	chr2	89156856	-	RPL23	chr17	37009354	-
80746	N/A	EC543503	KRT33B	chr17	39523962	-	RPL23	chr17	37006350	+
80746	N/A	EC579878	MACF1	chr1	39652738	+	RPL23	chr17	37006343	+
80746	KIRP	TCGA-GL-7966-01A	PIP4K2B	chr17	36933940	-	RPL23	chr17	37006728	-
80746	N/A	BU677197	PLCE1	chr10	96050224	+	RPL23	chr17	37006331	+
80746	STAD	TCGA-BR-A4PE-01A	PLXNB2	chr22	50745982	-	RPL23	chr17	37008985	-
80746	N/A	DB573606	PRR14	chr16	30667544	+	RPL23	chr17	37008919	-
80746	BRCA	TCGA-BH-A1F0-01A	PSMB3	chr17	36909587	+	RPL23	chr17	37009358	-
80746	N/A	EC527984	RP11-445O3.2	chr5	4454344	-	RPL23	chr17	37006672	-
101675	N/A	BI494952	RPL23	chr17	37006350	-	AKAP6	chr14	33287754	-
89663	N/A	CB050318	RPL23	chr17	37006334	-	ANO3	chr11	26294794	-
102136	PRAD	TCGA-CH-5751	RPL23	chr17	37008856	-	BRD2	chr6	32939371	+
102136	PRAD	TCGA-CH-5751-01A	RPL23	chr17	37008857	-	BRD2	chr6	32939372	+
98015	N/A	AI557367	RPL23	chr17	37006334	-	C19orf38	chr19	10964597	-
99602	N/A	DA438824	RPL23	chr17	37009278	-	CD164	chr6	109690218	-
91084	N/A	T90988	RPL23	chr17	37006650	+	CENPF	chr1	214819433	-
76259	N/A	AW022038	RPL23	chr17	37006334	-	CTC-326K19.6	chr19	50442677	+
85861	N/A	BF219414	RPL23	chr17	37006350	-	CYP27C1	chr2	127972381	-
76259	N/A	AI638150	RPL23	chr17	37008942	-	DFFA	chr1	10521539	-
89665	N/A	AA225438	RPL23	chr17	37006334	-	EFCAB6-AS1	chr22	43920603	-
96313	N/A	AA524904	RPL23	chr17	37006334	-	IFT46	chr11	118419101	-
87378	N/A	BG878350	RPL23	chr17	37008857	-	JARID2	chr6	15498517	-
89618	HNSC	TCGA-BB-7863	RPL23	chr17	37008020	-	KRT5	chr12	52913546	-
89618	HNSC	TCGA-CV-7095	RPL23	chr17	37008018	-	KRT5	chr12	52913545	-
76259	N/A	BY999398	RPL23	chr17	37006358	-	MED30	chr8	118545351	+
76259	N/A	BE265135	RPL23	chr17	37006343	-	MRPL10	chr17	45908870	-
93253	N/A	BP279136	RPL23	chr17	37006321	-	MUM1	chr19	1376810	-
89192	N/A	AA736898	RPL23	chr17	37006334	-	OSBP2	chr22	31231726	-
76259	N/A	BF219134	RPL23	chr17	37006334	-	PPME1	chr11	73963311	-
76259	N/A	AI826668	RPL23	chr17	37006372	+	PRKAB1	chr12	120119421	-
86255	BRCA	TCGA-D8-A1XJ-01A	RPL23	chr17	37008942	-	PSMB3	chr17	36912155	+
99718	N/A	CF124854	RPL23	chr17	37006334	-	RASSF3	chr12	65064117	-
80746	N/A	AI678191	RPL23	chr17	37006375	+	RPL23	chr17	37006668	-
80746	N/A	AI972799	RPL23	chr17	37006425	+	RPL23	chr17	37008897	-
101530	N/A	AW021386	RPL23	chr17	37006334	-	SLC41A3	chr3	125791135	+
89443	UCEC	TCGA-DI-A2QT-01A	RPL23	chr17	37009275	-	SMARCA5	chr4	144464662	+
79263	N/A	BP228022	RPL23	chr17	37006370	-	STAC	chr3	36570138	+
103076	N/A	BF246464	RPL23	chr17	37006334	-	TAF6	chr7	99715975	+
76259	BRCA	TCGA-A2-A1G1-01A	RPL23	chr17	37005910	-	TCAP	chr17	37822148	+
98567	OV	TCGA-23-1023	RPL23	chr17	37006320	-	TCOF1	chr5	149777916	+
95943	N/A	BF476398	RPL23	chr17	37009988	+	TEAD1	chr11	12773796	-
99698	N/A	BP228532	RPL23	chr17	37006351	-	XPO6	chr16	28162503	+
80746	UCEC	TCGA-DI-A2QT-01A	RPS6	chr9	19378366	-	RPL23	chr17	37009358	-
80746	N/A	EC563223	SAE1	chr19	47633259	+	RPL23	chr17	37006334	+
80746	N/A	CB134886	SERPINA1	chr14	94844909	+	RPL23	chr17	37008908	-
80747	PRAD	TCGA-HC-A6AO-01A	SERPINA3	chr14	95090983	-	RPL23	chr17	37009988	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
KIRP	RPL23	1.77692967596752	0.574886973807272	0.0057406708580895	0.00795908503337087	0.00576639952008122	320
KIRP	RPL23	1.77692967596752	0.574886973807272	0.0057406708580895	0.00795908503337087	0.00576639952008122	320
KIRC	RPL23	1.30727228937739	0.267942744525854	0.0263136374912631	0.0267316236951375	0.0263275583521906	604
KIRC	RPL23	1.30727228937739	0.267942744525854	0.0263136374912631	0.0267316236951375	0.0263275583521906	604
ACC	RPL23	1.86774476904447	0.624731697197637	0.0268824848668178	0.0263503680184162	0.0255654006003477	79
BRCA	RPL23	0.779077174796105	-0.249645168960503	0.0321657266073813	0.0292272778311709	0.0325207005424027	1200

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	RPL23	0.0288329670095447	0.81

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL23	6.08360085926774e-05	0.002
GBM	RPL23	0.0242382194417581	0.78
PRAD	RPL23	0.0318826796106138	0.99

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	1	GENOMICS_ENGLAND