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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CD28 (NCBI Gene ID:940)

Gene Summary

Gene Summary

Gene Information	Gene Name: CD28
	Gene ID: 940
	Gene Symbol	CD28
	Gene ID	940
	Gene Name	CD28 molecule
	Synonyms	Tp44
	Cytomap	2q33.2
	Type of Gene	protein-coding
	Description	T-cell-specific surface glycoprotein CD28CD28 antigen
	Modification date	20200313
	UniProtAcc	P10747

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD28	GO:0032733	positive regulation of interleukin-10 production	8617933
Hgene	CD28	GO:0032753	positive regulation of interleukin-4 production	8617933
Hgene	CD28	GO:0042102	positive regulation of T cell proliferation	3159820\|8617933
Hgene	CD28	GO:0045066	regulatory T cell differentiation	18641304
Hgene	CD28	GO:0045086	positive regulation of interleukin-2 biosynthetic process	3875683
Hgene	CD28	GO:0045840	positive regulation of mitotic nuclear division	3159820

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CD28	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'CD28[title] AND translation [title] AND human.'

Gene	Title	PMID
CD28	CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway	15611240

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000324106	204591355	204591712	In-frame
ENST00000324106	204594370	204594495	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000324106	204591355	204591712	4829	202	558	220	17	136

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	CD28	-5.52665880266634	0.00293293595314026

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
ACC	CD28	hsa-miR-24-3p	75	-0.371505082545494	0.000749283934792691
ACC	CD28	hsa-miR-27a-3p	94	-0.311764348456398	0.00515912625744577

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	CD28	3	2	0.0253419251553674	0.699209831223629	0.512035029239766	0.289003900690106	0.386797197751331
KIRP	CD28	3	2	0.0415357427121907	0.796525047923323	0.537866	-0.704904507123203	-0.48563888412

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
DLBC	CD28	0.013408661	0.047829069
ESCA	CD28	-0.020538899	0.048546783

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CD28 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	CGC	CD28	CD209	0.814893396	6.38E-20
ACC	IUPHAR	CD28	CD209	0.814893396	6.38E-20
BLCA	Cell metabolism gene	CD28	PIK3R5	0.855995726	1.48E-123
BLCA	CGC	CD28	CCR4	0.800511583	2.57E-96
BLCA	CGC	CD28	IRF4	0.809324341	4.96E-100
BLCA	CGC	CD28	IL21R	0.82574328	1.69E-107
BLCA	CGC	CD28	WAS	0.836848542	5.22E-113
BLCA	CGC	CD28	RHOH	0.847162144	1.64E-118
BLCA	CGC	CD28	IKZF1	0.857112843	3.21E-124
BLCA	CGC	CD28	ITK	0.861100411	1.25E-126
BLCA	CGC	CD28	BTK	0.863552349	3.77E-128
BLCA	CGC	CD28	PTPRC	0.882988685	2.36E-141
BLCA	Epifactor	CD28	IKZF1	0.857112843	3.21E-124
BLCA	IUPHAR	CD28	CCR4	0.800511583	2.57E-96
BLCA	IUPHAR	CD28	CD2	0.801244677	1.28E-96
BLCA	IUPHAR	CD28	KCNA3	0.801321448	1.19E-96
BLCA	IUPHAR	CD28	CMKLR1	0.801567061	9.45E-97
BLCA	IUPHAR	CD28	C3AR1	0.808686407	9.35E-100
BLCA	IUPHAR	CD28	LAIR1	0.808903968	7.53E-100
BLCA	IUPHAR	CD28	TLR8	0.81120446	7.55E-101
BLCA	IUPHAR	CD28	ICOS	0.813988631	4.46E-102
BLCA	IUPHAR	CD28	CD52	0.815361993	1.09E-102
BLCA	IUPHAR	CD28	GZMK	0.815784843	7.02E-103
BLCA	IUPHAR	CD28	SLCO2B1	0.817437084	1.26E-103
BLCA	IUPHAR	CD28	GPR183	0.818543552	3.94E-104
BLCA	IUPHAR	CD28	IL2RA	0.818787275	3.05E-104
BLCA	IUPHAR	CD28	CD3E	0.823249588	2.58E-106
BLCA	IUPHAR	CD28	CD27	0.823701508	1.58E-106
BLCA	IUPHAR	CD28	IL21R	0.82574328	1.69E-107
BLCA	IUPHAR	CD28	ITGB2	0.828289402	1.00E-108
BLCA	IUPHAR	CD28	AOAH	0.828419353	8.64E-109
BLCA	IUPHAR	CD28	ITGAL	0.8345183	8.09E-112
BLCA	IUPHAR	CD28	GPR65	0.835894299	1.61E-112
BLCA	IUPHAR	CD28	CYBB	0.837512417	2.37E-113
BLCA	IUPHAR	CD28	P2RY10	0.841070895	3.26E-115
BLCA	IUPHAR	CD28	PIK3R5	0.855995726	1.48E-123
BLCA	IUPHAR	CD28	CD37	0.860101778	5.09E-126
BLCA	IUPHAR	CD28	ITK	0.861100411	1.25E-126
BLCA	IUPHAR	CD28	BTK	0.863552349	3.77E-128
BLCA	IUPHAR	CD28	PTPRC	0.882988685	2.36E-141
BLCA	IUPHAR	CD28	IL10RA	0.884094334	3.57E-142
BLCA	Kinase	CD28	ITK	0.861100411	1.25E-126
BLCA	Kinase	CD28	BTK	0.863552349	3.77E-128
BLCA	TF	CD28	SPI1	0.808210839	1.50E-99
BLCA	TF	CD28	IRF4	0.809324341	4.96E-100
BLCA	TF	CD28	IRF8	0.823974062	1.17E-106
BLCA	TF	CD28	ZNF831	0.840475455	6.72E-115
BLCA	TF	CD28	IKZF1	0.857112843	3.21E-124
BLCA	TSG	CD28	AIF1	0.808129784	1.62E-99
BLCA	TSG	CD28	SPI1	0.808210839	1.50E-99
BLCA	TSG	CD28	IRF4	0.809324341	4.96E-100
BLCA	TSG	CD28	IRF8	0.823974062	1.17E-106
BLCA	TSG	CD28	DOK2	0.83116241	3.89E-110
BLCA	TSG	CD28	IKZF1	0.857112843	3.21E-124
BLCA	TSG	CD28	BTK	0.863552349	3.77E-128
BLCA	TSG	CD28	PTPRC	0.882988685	2.36E-141
BRCA	CGC	CD28	IKZF1	0.812324205	4.89E-287
BRCA	CGC	CD28	PTPRC	0.833399825	1.894167134e-315
BRCA	Epifactor	CD28	IKZF1	0.812324205	4.89E-287
BRCA	IUPHAR	CD28	IL10RA	0.825878625	7.17E-305
BRCA	IUPHAR	CD28	PTPRC	0.833399825	1.894167134e-315
BRCA	TF	CD28	IKZF1	0.812324205	4.89E-287
BRCA	TSG	CD28	IKZF1	0.812324205	4.89E-287
BRCA	TSG	CD28	PTPRC	0.833399825	1.894167134e-315
CESC	CGC	CD28	BTK	0.816677463	4.87E-75
CESC	CGC	CD28	IKZF1	0.821292529	1.44E-76
CESC	CGC	CD28	P2RY8	0.825147305	7.06E-78
CESC	Epifactor	CD28	IKZF1	0.821292529	1.44E-76
CESC	IUPHAR	CD28	CXCR5	0.809052764	1.32E-72
CESC	IUPHAR	CD28	ICOS	0.809109466	1.27E-72
CESC	IUPHAR	CD28	P2RY10	0.810830164	3.65E-73
CESC	IUPHAR	CD28	ITGAL	0.813530004	5.07E-74
CESC	IUPHAR	CD28	CD27	0.815103559	1.58E-74
CESC	IUPHAR	CD28	BTK	0.816677463	4.87E-75
CESC	IUPHAR	CD28	CD37	0.824226263	1.46E-77
CESC	IUPHAR	CD28	P2RY8	0.825147305	7.06E-78
CESC	IUPHAR	CD28	IL10RA	0.834308273	3.99E-81
CESC	Kinase	CD28	BTK	0.816677463	4.87E-75
CESC	TF	CD28	IKZF1	0.821292529	1.44E-76
CESC	TF	CD28	ZNF831	0.844287316	6.75E-85
CESC	TSG	CD28	BTK	0.816677463	4.87E-75
CESC	TSG	CD28	IKZF1	0.821292529	1.44E-76
CHOL	Cell metabolism gene	CD28	GNG2	0.810619959	1.50E-11
CHOL	Cell metabolism gene	CD28	PIK3CG	0.824934518	3.22E-12
CHOL	CGC	CD28	CXCR4	0.801750007	3.64E-11
CHOL	CGC	CD28	BTK	0.803632746	3.02E-11
CHOL	CGC	CD28	RHOH	0.808396047	1.88E-11
CHOL	CGC	CD28	CCR4	0.817353268	7.38E-12
CHOL	CGC	CD28	IL7R	0.826433812	2.72E-12
CHOL	CGC	CD28	CCR7	0.844011141	3.30E-13
CHOL	CGC	CD28	ITK	0.847466584	2.11E-13
CHOL	CGC	CD28	PTPRC	0.861438125	3.10E-14
CHOL	Epifactor	CD28	IKZF3	0.806109111	2.36E-11
CHOL	IUPHAR	CD28	CXCR4	0.801750007	3.64E-11
CHOL	IUPHAR	CD28	BTK	0.803632746	3.02E-11
CHOL	IUPHAR	CD28	CD6	0.812797466	1.19E-11
CHOL	IUPHAR	CD28	CCR4	0.817353268	7.38E-12
CHOL	IUPHAR	CD28	GPR65	0.818071016	6.84E-12
CHOL	IUPHAR	CD28	P2RY10	0.821157085	4.89E-12
CHOL	IUPHAR	CD28	PIK3CG	0.824934518	3.22E-12
CHOL	IUPHAR	CD28	IL7R	0.826433812	2.72E-12
CHOL	IUPHAR	CD28	IL12RB1	0.828283165	2.20E-12
CHOL	IUPHAR	CD28	ICOS	0.829045588	2.02E-12
CHOL	IUPHAR	CD28	IL10RA	0.838741891	6.37E-13
CHOL	IUPHAR	CD28	CCR7	0.844011141	3.30E-13
CHOL	IUPHAR	CD28	ITK	0.847466584	2.11E-13
CHOL	IUPHAR	CD28	ITGA4	0.852108994	1.14E-13
CHOL	IUPHAR	CD28	PTPN22	0.855265373	7.42E-14
CHOL	IUPHAR	CD28	PTPRC	0.861438125	3.10E-14
CHOL	Kinase	CD28	BTK	0.803632746	3.02E-11
CHOL	Kinase	CD28	ITK	0.847466584	2.11E-13
CHOL	TF	CD28	IKZF3	0.806109111	2.36E-11
CHOL	TF	CD28	ETS1	0.807939133	1.97E-11
CHOL	TSG	CD28	BTK	0.803632746	3.02E-11
CHOL	TSG	CD28	IKZF3	0.806109111	2.36E-11
CHOL	TSG	CD28	PTPRC	0.861438125	3.10E-14
COAD	Cell metabolism gene	CD28	CD38	0.803700875	1.03E-75
COAD	Cell metabolism gene	CD28	CHST2	0.807970086	4.15E-77
COAD	Cell metabolism gene	CD28	PIK3R5	0.851122767	1.57E-93
COAD	Cell metabolism gene	CD28	PIK3CG	0.876841128	4.98E-106
COAD	CGC	CD28	IL21R	0.804271053	6.75E-76
COAD	CGC	CD28	IRF4	0.804820997	4.47E-76
COAD	CGC	CD28	IL7R	0.80533827	3.04E-76
COAD	CGC	CD28	CSF1R	0.816153928	6.94E-80
COAD	CGC	CD28	CCR7	0.82385254	1.26E-82
COAD	CGC	CD28	RHOH	0.824409562	7.89E-83
COAD	CGC	CD28	PRKCB	0.830779323	3.29E-85
COAD	CGC	CD28	CCR4	0.849244826	1.04E-92
COAD	CGC	CD28	LCP1	0.855187707	2.43E-95
COAD	CGC	CD28	P2RY8	0.856550602	5.82E-96
COAD	CGC	CD28	ITK	0.858657644	6.22E-97
COAD	CGC	CD28	FLI1	0.861032314	4.79E-98
COAD	CGC	CD28	BTK	0.874341029	1.07E-104
COAD	CGC	CD28	WAS	0.876549833	7.15E-106
COAD	CGC	CD28	IKZF1	0.903497955	2.33E-122
COAD	CGC	CD28	PTPRC	0.910970841	8.28E-128
COAD	Epifactor	CD28	SFMBT2	0.823581762	1.58E-82
COAD	Epifactor	CD28	PRKCB	0.830779323	3.29E-85
COAD	Epifactor	CD28	IKZF1	0.903497955	2.33E-122
COAD	IUPHAR	CD28	TLR10	0.801096201	7.05E-75
COAD	IUPHAR	CD28	GPR65	0.803163323	1.54E-75
COAD	IUPHAR	CD28	GPR183	0.803670568	1.06E-75
COAD	IUPHAR	CD28	CD38	0.803700875	1.03E-75
COAD	IUPHAR	CD28	IL21R	0.804271053	6.75E-76
COAD	IUPHAR	CD28	LAIR1	0.804884242	4.27E-76
COAD	IUPHAR	CD28	IL7R	0.80533827	3.04E-76
COAD	IUPHAR	CD28	P2RY13	0.807331646	6.74E-77
COAD	IUPHAR	CD28	CD86	0.808755756	2.28E-77
COAD	IUPHAR	CD28	ADORA2A	0.810369612	6.57E-78
COAD	IUPHAR	CD28	CCR2	0.813663285	5.02E-79
COAD	IUPHAR	CD28	CSF1R	0.816153928	6.94E-80
COAD	IUPHAR	CD28	CCR5	0.816232167	6.52E-80
COAD	IUPHAR	CD28	CCR7	0.82385254	1.26E-82
COAD	IUPHAR	CD28	GPR174	0.824212374	9.31E-83
COAD	IUPHAR	CD28	CYBB	0.828125789	3.32E-84
COAD	IUPHAR	CD28	SLAMF7	0.828891477	1.71E-84
COAD	IUPHAR	CD28	CMKLR1	0.83034005	4.84E-85
COAD	IUPHAR	CD28	PRKCB	0.830779323	3.29E-85
COAD	IUPHAR	CD28	CD27	0.832197443	9.42E-86
COAD	IUPHAR	CD28	TLR7	0.83451273	1.19E-86
COAD	IUPHAR	CD28	MAP4K1	0.834638847	1.06E-86
COAD	IUPHAR	CD28	KCNA3	0.837225746	1.01E-87
COAD	IUPHAR	CD28	LILRB1	0.837949971	5.21E-88
COAD	IUPHAR	CD28	PYHIN1	0.844157735	1.51E-90
COAD	IUPHAR	CD28	CD37	0.845289984	5.07E-91
COAD	IUPHAR	CD28	CCR4	0.849244826	1.04E-92
COAD	IUPHAR	CD28	ITGA4	0.849502263	8.02E-93
COAD	IUPHAR	CD28	CYSLTR1	0.849859327	5.61E-93
COAD	IUPHAR	CD28	PIK3R5	0.851122767	1.57E-93
COAD	IUPHAR	CD28	P2RY8	0.856550602	5.82E-96
COAD	IUPHAR	CD28	ITK	0.858657644	6.22E-97
COAD	IUPHAR	CD28	CSF2RB	0.861509078	2.84E-98
COAD	IUPHAR	CD28	IL10RA	0.869037364	5.86E-102
COAD	IUPHAR	CD28	P2RY10	0.869472614	3.53E-102
COAD	IUPHAR	CD28	ITGAL	0.870431078	1.15E-102
COAD	IUPHAR	CD28	BTK	0.874341029	1.07E-104
COAD	IUPHAR	CD28	PIK3CG	0.876841128	4.98E-106
COAD	IUPHAR	CD28	CD4	0.882368329	4.40E-109
COAD	IUPHAR	CD28	PTPRC	0.910970841	8.28E-128
COAD	Kinase	CD28	CSF1R	0.816153928	6.94E-80
COAD	Kinase	CD28	PRKCB	0.830779323	3.29E-85
COAD	Kinase	CD28	MAP4K1	0.834638847	1.06E-86
COAD	Kinase	CD28	ITK	0.858657644	6.22E-97
COAD	Kinase	CD28	BTK	0.874341029	1.07E-104
COAD	TF	CD28	IRF4	0.804820997	4.47E-76
COAD	TF	CD28	ZNF831	0.852350918	4.52E-94
COAD	TF	CD28	FLI1	0.861032314	4.79E-98
COAD	TF	CD28	IKZF1	0.903497955	2.33E-122
COAD	TSG	CD28	PLXNC1	0.803571074	1.14E-75
COAD	TSG	CD28	IRF4	0.804820997	4.47E-76
COAD	TSG	CD28	TNFAIP8L2	0.819637585	4.14E-81
COAD	TSG	CD28	DOK2	0.822924917	2.74E-82
COAD	TSG	CD28	PRKCB	0.830779323	3.29E-85
COAD	TSG	CD28	MAP4K1	0.834638847	1.06E-86
COAD	TSG	CD28	PYHIN1	0.844157735	1.51E-90
COAD	TSG	CD28	RASSF2	0.845462107	4.29E-91
COAD	TSG	CD28	BTK	0.874341029	1.07E-104
COAD	TSG	CD28	CD4	0.882368329	4.40E-109
COAD	TSG	CD28	IKZF1	0.903497955	2.33E-122
COAD	TSG	CD28	PTPRC	0.910970841	8.28E-128
DLBC	Cell metabolism gene	CD28	MAN1C1	0.802553589	6.91E-12
DLBC	Cell metabolism gene	CD28	PDE3B	0.876435734	3.33E-16
DLBC	Cell metabolism gene	CD28	INPP4B	0.877106738	2.96E-16
DLBC	Cell metabolism gene	CD28	PIK3R5	0.888628326	3.50E-17
DLBC	CGC	CD28	ITK	0.826106072	4.88E-13
DLBC	CGC	CD28	MAF	0.85887767	5.82E-15
DLBC	CGC	CD28	GATA3	0.907859827	5.54E-19
DLBC	CGC	CD28	BCL11B	0.975689978	5.66E-32
DLBC	Epifactor	CD28	PRDM8	0.833152942	2.04E-13
DLBC	IUPHAR	CD28	TNFRSF25	0.801282193	7.89E-12
DLBC	IUPHAR	CD28	SBK1	0.814725038	1.84E-12
DLBC	IUPHAR	CD28	ITK	0.826106072	4.88E-13
DLBC	IUPHAR	CD28	GZMK	0.837262771	1.21E-13
DLBC	IUPHAR	CD28	CTLA4	0.838947056	9.69E-14
DLBC	IUPHAR	CD28	GPR171	0.853716623	1.25E-14
DLBC	IUPHAR	CD28	AAK1	0.867879695	1.41E-15
DLBC	IUPHAR	CD28	CXCR6	0.869271599	1.12E-15
DLBC	IUPHAR	CD28	PDE3B	0.876435734	3.33E-16
DLBC	IUPHAR	CD28	INPP4B	0.877106738	2.96E-16
DLBC	IUPHAR	CD28	PIK3R5	0.888628326	3.50E-17
DLBC	IUPHAR	CD28	KCNK5	0.893280178	1.38E-17
DLBC	IUPHAR	CD28	ICOS	0.920980007	1.87E-20
DLBC	IUPHAR	CD28	CD2	0.926614417	3.62E-21
DLBC	IUPHAR	CD28	CD3E	0.944211329	8.01E-24
DLBC	IUPHAR	CD28	PRKCQ	0.944650878	6.71E-24
DLBC	Kinase	CD28	SBK1	0.814725038	1.84E-12
DLBC	Kinase	CD28	ITK	0.826106072	4.88E-13
DLBC	Kinase	CD28	AAK1	0.867879695	1.41E-15
DLBC	Kinase	CD28	PRKCQ	0.944650878	6.71E-24
DLBC	TF	CD28	ZNF74	0.801628212	7.61E-12
DLBC	TF	CD28	EOMES	0.83211698	2.33E-13
DLBC	TF	CD28	PRDM8	0.833152942	2.04E-13
DLBC	TF	CD28	MAF	0.85887767	5.82E-15
DLBC	TF	CD28	GATA3	0.907859827	5.54E-19
DLBC	TF	CD28	BCL11B	0.975689978	5.66E-32
DLBC	TSG	CD28	INPP4B	0.877106738	2.96E-16
ESCA	Cell metabolism gene	CD28	PIK3R5	0.833142215	8.58E-52
ESCA	CGC	CD28	WAS	0.80871892	1.37E-46
ESCA	CGC	CD28	IL21R	0.827761173	1.41E-50
ESCA	CGC	CD28	BTK	0.827928649	1.29E-50
ESCA	CGC	CD28	CCR4	0.844660328	1.51E-54
ESCA	CGC	CD28	IKZF1	0.851242597	3.17E-56
ESCA	CGC	CD28	ITK	0.852251625	1.72E-56
ESCA	CGC	CD28	PTPRC	0.895624354	3.56E-70
ESCA	Epifactor	CD28	IKZF1	0.851242597	3.17E-56
ESCA	IUPHAR	CD28	CCR5	0.800773778	4.67E-45
ESCA	IUPHAR	CD28	CCR8	0.802538144	2.16E-45
ESCA	IUPHAR	CD28	KCNA3	0.802925091	1.82E-45
ESCA	IUPHAR	CD28	GPR174	0.804292758	9.97E-46
ESCA	IUPHAR	CD28	ICOS	0.814696314	8.59E-48
ESCA	IUPHAR	CD28	GPR65	0.823176553	1.42E-49
ESCA	IUPHAR	CD28	CD4	0.825348748	4.80E-50
ESCA	IUPHAR	CD28	IL21R	0.827761173	1.41E-50
ESCA	IUPHAR	CD28	BTK	0.827928649	1.29E-50
ESCA	IUPHAR	CD28	PIK3R5	0.833142215	8.58E-52
ESCA	IUPHAR	CD28	CCR4	0.844660328	1.51E-54
ESCA	IUPHAR	CD28	IL10RA	0.849183214	1.08E-55
ESCA	IUPHAR	CD28	ITK	0.852251625	1.72E-56
ESCA	IUPHAR	CD28	ITGAL	0.853638556	7.42E-57
ESCA	IUPHAR	CD28	P2RY10	0.857670348	6.07E-58
ESCA	IUPHAR	CD28	PTPRC	0.895624354	3.56E-70
ESCA	Kinase	CD28	BTK	0.827928649	1.29E-50
ESCA	Kinase	CD28	ITK	0.852251625	1.72E-56
ESCA	TF	CD28	ZNF831	0.814720737	8.49E-48
ESCA	TF	CD28	IKZF1	0.851242597	3.17E-56
ESCA	TSG	CD28	CD4	0.825348748	4.80E-50
ESCA	TSG	CD28	BTK	0.827928649	1.29E-50
ESCA	TSG	CD28	IKZF1	0.851242597	3.17E-56
ESCA	TSG	CD28	PTPRC	0.895624354	3.56E-70
HNSC	Cell metabolism gene	CD28	PIK3CG	0.834541459	3.89E-148
HNSC	Cell metabolism gene	CD28	PIK3R5	0.842105318	2.28E-153
HNSC	CGC	CD28	WAS	0.815464424	4.82E-136
HNSC	CGC	CD28	RHOH	0.820465061	4.50E-139
HNSC	CGC	CD28	CCR4	0.821027377	2.03E-139
HNSC	CGC	CD28	BTK	0.846072905	3.19E-156
HNSC	CGC	CD28	P2RY8	0.849674937	6.92E-159
HNSC	CGC	CD28	IL21R	0.850783301	1.02E-159
HNSC	CGC	CD28	PRKCB	0.859997276	6.37E-167
HNSC	CGC	CD28	ITK	0.874528246	2.14E-179
HNSC	CGC	CD28	IKZF1	0.898270821	1.48E-203
HNSC	CGC	CD28	PTPRC	0.904032073	2.50E-210
HNSC	Epifactor	CD28	FOXP3	0.815189911	7.03E-136
HNSC	Epifactor	CD28	PRKCB	0.859997276	6.37E-167
HNSC	Epifactor	CD28	IKZF1	0.898270821	1.48E-203
HNSC	IUPHAR	CD28	LILRB1	0.803030471	6.83E-129
HNSC	IUPHAR	CD28	CD27	0.805808911	1.91E-130
HNSC	IUPHAR	CD28	CXCR3	0.806898333	4.63E-131
HNSC	IUPHAR	CD28	IL2RB	0.808346515	6.94E-132
HNSC	IUPHAR	CD28	CD2	0.810531891	3.83E-133
HNSC	IUPHAR	CD28	GPR174	0.811240527	1.49E-133
HNSC	IUPHAR	CD28	IL2RA	0.81473717	1.31E-135
HNSC	IUPHAR	CD28	ICOS	0.820702629	3.21E-139
HNSC	IUPHAR	CD28	CCR4	0.821027377	2.03E-139
HNSC	IUPHAR	CD28	CD3E	0.822295278	3.31E-140
HNSC	IUPHAR	CD28	TIGIT	0.827987146	8.17E-144
HNSC	IUPHAR	CD28	CYBB	0.828330895	4.90E-144
HNSC	IUPHAR	CD28	KCNA3	0.829750215	5.86E-145
HNSC	IUPHAR	CD28	PIK3CG	0.834541459	3.89E-148
HNSC	IUPHAR	CD28	CCR5	0.835348875	1.11E-148
HNSC	IUPHAR	CD28	PIK3R5	0.842105318	2.28E-153
HNSC	IUPHAR	CD28	TNFRSF1B	0.844817554	2.60E-155
HNSC	IUPHAR	CD28	BTK	0.846072905	3.19E-156
HNSC	IUPHAR	CD28	P2RY8	0.849674937	6.92E-159
HNSC	IUPHAR	CD28	IL21R	0.850783301	1.02E-159
HNSC	IUPHAR	CD28	CD37	0.851390199	3.53E-160
HNSC	IUPHAR	CD28	GPR65	0.851816237	1.67E-160
HNSC	IUPHAR	CD28	CD4	0.854377443	1.81E-162
HNSC	IUPHAR	CD28	ITGAL	0.855298451	3.47E-163
HNSC	IUPHAR	CD28	PRKCB	0.859997276	6.37E-167
HNSC	IUPHAR	CD28	ITK	0.874528246	2.14E-179
HNSC	IUPHAR	CD28	IL10RA	0.884501254	6.78E-189
HNSC	IUPHAR	CD28	P2RY10	0.889745108	3.01E-194
HNSC	IUPHAR	CD28	PTPRC	0.904032073	2.50E-210
HNSC	Kinase	CD28	BTK	0.846072905	3.19E-156
HNSC	Kinase	CD28	PRKCB	0.859997276	6.37E-167
HNSC	Kinase	CD28	ITK	0.874528246	2.14E-179
HNSC	TF	CD28	FOXP3	0.815189911	7.03E-136
HNSC	TF	CD28	ZNF831	0.863078809	1.90E-169
HNSC	TF	CD28	IRF8	0.875735319	1.67E-180
HNSC	TF	CD28	IKZF1	0.898270821	1.48E-203
HNSC	TSG	CD28	FOXP3	0.815189911	7.03E-136
HNSC	TSG	CD28	BTK	0.846072905	3.19E-156
HNSC	TSG	CD28	RASSF2	0.848672797	3.87E-158
HNSC	TSG	CD28	CD4	0.854377443	1.81E-162
HNSC	TSG	CD28	PRKCB	0.859997276	6.37E-167
HNSC	TSG	CD28	IRF8	0.875735319	1.67E-180
HNSC	TSG	CD28	IKZF1	0.898270821	1.48E-203
HNSC	TSG	CD28	PTPRC	0.904032073	2.50E-210
KIRP	CGC	CD28	IKZF1	0.80022037	2.90E-73
KIRP	CGC	CD28	LCP1	0.828595802	7.24E-83
KIRP	Epifactor	CD28	IKZF1	0.80022037	2.90E-73
KIRP	IUPHAR	CD28	CD4	0.800412355	2.53E-73
KIRP	IUPHAR	CD28	HCK	0.80076486	1.96E-73
KIRP	IUPHAR	CD28	FPR3	0.80235487	6.24E-74
KIRP	IUPHAR	CD28	IL10RA	0.813583368	1.40E-77
KIRP	Kinase	CD28	HCK	0.80076486	1.96E-73
KIRP	TF	CD28	IKZF1	0.80022037	2.90E-73
KIRP	TSG	CD28	IKZF1	0.80022037	2.90E-73
KIRP	TSG	CD28	CD4	0.800412355	2.53E-73
LAML	Cell metabolism gene	CD28	RORA	0.848956336	3.09E-49
LAML	CGC	CD28	LEF1	0.856656098	4.99E-51
LAML	CGC	CD28	LCK	0.86355718	1.00E-52
LAML	CGC	CD28	IL7R	0.891332985	1.21E-60
LAML	CGC	CD28	ITK	0.896707135	2.01E-62
LAML	CGC	CD28	BCL11B	0.909633135	3.85E-67
LAML	IUPHAR	CD28	CD27	0.808361261	3.36E-41
LAML	IUPHAR	CD28	CD6	0.812716753	5.75E-42
LAML	IUPHAR	CD28	RASGRP1	0.822035722	1.12E-43
LAML	IUPHAR	CD28	CD247	0.824885516	3.21E-44
LAML	IUPHAR	CD28	RORA	0.848956336	3.09E-49
LAML	IUPHAR	CD28	CAMK4	0.860730758	5.09E-52
LAML	IUPHAR	CD28	LCK	0.86355718	1.00E-52
LAML	IUPHAR	CD28	CD3E	0.884508927	1.64E-58
LAML	IUPHAR	CD28	ICOS	0.88548213	8.30E-59
LAML	IUPHAR	CD28	IL7R	0.891332985	1.21E-60
LAML	IUPHAR	CD28	ITK	0.896707135	2.01E-62
LAML	Kinase	CD28	CAMK4	0.860730758	5.09E-52
LAML	Kinase	CD28	LCK	0.86355718	1.00E-52
LAML	Kinase	CD28	ITK	0.896707135	2.01E-62
LAML	TF	CD28	TCF7	0.839425956	3.76E-47
LAML	TF	CD28	RORA	0.848956336	3.09E-49
LAML	TF	CD28	TSHZ2	0.85163612	7.55E-50
LAML	TF	CD28	LEF1	0.856656098	4.99E-51
LAML	TF	CD28	BCL11B	0.909633135	3.85E-67
LUAD	CGC	CD28	CCR4	0.806867354	2.47E-133
LUAD	IUPHAR	CD28	CCR4	0.806867354	2.47E-133
LUAD	IUPHAR	CD28	P2RY10	0.812780832	8.35E-137
LUSC	Cell metabolism gene	CD28	PIK3CG	0.8174126	4.30E-134
LUSC	CGC	CD28	BTK	0.809885255	9.42E-130
LUSC	CGC	CD28	IL21R	0.810511438	4.17E-130
LUSC	CGC	CD28	IKZF1	0.816706775	1.12E-133
LUSC	CGC	CD28	RHOH	0.822625769	3.21E-137
LUSC	CGC	CD28	P2RY8	0.845233017	4.54E-152
LUSC	CGC	CD28	ITK	0.854923205	3.49E-159
LUSC	CGC	CD28	PTPRC	0.863150818	1.21E-165
LUSC	CGC	CD28	CCR4	0.877022287	1.50E-177
LUSC	Epifactor	CD28	IKZF1	0.816706775	1.12E-133
LUSC	IUPHAR	CD28	CD37	0.800358521	1.58E-124
LUSC	IUPHAR	CD28	IL12RB1	0.800982364	7.32E-125
LUSC	IUPHAR	CD28	ICOS	0.802696378	8.76E-126
LUSC	IUPHAR	CD28	PYHIN1	0.806878412	4.51E-128
LUSC	IUPHAR	CD28	PTPN22	0.808929848	3.24E-129
LUSC	IUPHAR	CD28	BTK	0.809885255	9.42E-130
LUSC	IUPHAR	CD28	IL21R	0.810511438	4.17E-130
LUSC	IUPHAR	CD28	CD3E	0.811448965	1.23E-130
LUSC	IUPHAR	CD28	PIK3CG	0.8174126	4.30E-134
LUSC	IUPHAR	CD28	CCR5	0.817688066	2.95E-134
LUSC	IUPHAR	CD28	LILRB1	0.817967463	2.02E-134
LUSC	IUPHAR	CD28	GPR174	0.818713206	7.29E-135
LUSC	IUPHAR	CD28	CD4	0.818938584	5.35E-135
LUSC	IUPHAR	CD28	GZMK	0.82237734	4.55E-137
LUSC	IUPHAR	CD28	CCR2	0.826917238	7.17E-140
LUSC	IUPHAR	CD28	GPR183	0.832773142	1.31E-143
LUSC	IUPHAR	CD28	P2RY8	0.845233017	4.54E-152
LUSC	IUPHAR	CD28	ITK	0.854923205	3.49E-159
LUSC	IUPHAR	CD28	IL10RA	0.862601126	3.37E-165
LUSC	IUPHAR	CD28	PTPRC	0.863150818	1.21E-165
LUSC	IUPHAR	CD28	CCR4	0.877022287	1.50E-177
LUSC	IUPHAR	CD28	P2RY10	0.886507032	1.48E-186
LUSC	Kinase	CD28	BTK	0.809885255	9.42E-130
LUSC	Kinase	CD28	ITK	0.854923205	3.49E-159
LUSC	TF	CD28	IKZF1	0.816706775	1.12E-133
LUSC	TF	CD28	IRF8	0.822079012	6.91E-137
LUSC	TSG	CD28	PYHIN1	0.806878412	4.51E-128
LUSC	TSG	CD28	BTK	0.809885255	9.42E-130
LUSC	TSG	CD28	IKZF1	0.816706775	1.12E-133
LUSC	TSG	CD28	CD4	0.818938584	5.35E-135
LUSC	TSG	CD28	IRF8	0.822079012	6.91E-137
LUSC	TSG	CD28	PTPRC	0.863150818	1.21E-165
PAAD	Cell metabolism gene	CD28	PIK3R5	0.817231093	3.45E-45
PAAD	Cell metabolism gene	CD28	PIP4K2A	0.825209072	8.95E-47
PAAD	CGC	CD28	LCP1	0.815657896	6.94E-45
PAAD	CGC	CD28	BCL2	0.819019237	1.55E-45
PAAD	CGC	CD28	WAS	0.844681056	5.21E-51
PAAD	CGC	CD28	IL7R	0.846875455	1.60E-51
PAAD	CGC	CD28	IRF4	0.851933463	9.72E-53
PAAD	CGC	CD28	FLI1	0.857523438	3.90E-54
PAAD	CGC	CD28	BTK	0.871963864	4.87E-58
PAAD	CGC	CD28	CCR7	0.88107114	9.42E-61
PAAD	CGC	CD28	PRKCB	0.883539204	1.59E-61
PAAD	CGC	CD28	CCR4	0.897151204	3.90E-66
PAAD	CGC	CD28	ITK	0.899587916	4.99E-67
PAAD	CGC	CD28	PTPRC	0.914840334	3.39E-73
PAAD	CGC	CD28	IKZF1	0.915621503	1.53E-73
PAAD	Epifactor	CD28	SP140	0.804897854	6.97E-43
PAAD	Epifactor	CD28	IKZF3	0.814041747	1.41E-44
PAAD	Epifactor	CD28	FOXP3	0.818781269	1.72E-45
PAAD	Epifactor	CD28	PRKCB	0.883539204	1.59E-61
PAAD	Epifactor	CD28	IKZF1	0.915621503	1.53E-73
PAAD	IUPHAR	CD28	LILRB1	0.802102125	2.20E-42
PAAD	IUPHAR	CD28	SP140	0.804897854	6.97E-43
PAAD	IUPHAR	CD28	CCR2	0.808327333	1.66E-43
PAAD	IUPHAR	CD28	TLR10	0.809117378	1.18E-43
PAAD	IUPHAR	CD28	NLRC3	0.809942731	8.33E-44
PAAD	IUPHAR	CD28	CYSLTR1	0.810890445	5.55E-44
PAAD	IUPHAR	CD28	CD4	0.814891443	9.73E-45
PAAD	IUPHAR	CD28	PRKCH	0.815763788	6.62E-45
PAAD	IUPHAR	CD28	PIK3R5	0.817231093	3.45E-45
PAAD	IUPHAR	CD28	GPR183	0.817703945	2.79E-45
PAAD	IUPHAR	CD28	BCL2	0.819019237	1.55E-45
PAAD	IUPHAR	CD28	PIP4K2A	0.825209072	8.95E-47
PAAD	IUPHAR	CD28	CTLA4	0.825351329	8.37E-47
PAAD	IUPHAR	CD28	CXCR6	0.830993445	5.63E-48
PAAD	IUPHAR	CD28	ABCD2	0.831171387	5.16E-48
PAAD	IUPHAR	CD28	CD37	0.833478528	1.66E-48
PAAD	IUPHAR	CD28	KCNA3	0.834161249	1.18E-48
PAAD	IUPHAR	CD28	CD27	0.835672215	5.56E-49
PAAD	IUPHAR	CD28	CD247	0.83799173	1.72E-49
PAAD	IUPHAR	CD28	GPR65	0.843090759	1.21E-50
PAAD	IUPHAR	CD28	GZMK	0.843211561	1.14E-50
PAAD	IUPHAR	CD28	SLC9A9	0.844083355	7.16E-51
PAAD	IUPHAR	CD28	GPR174	0.84535692	3.62E-51
PAAD	IUPHAR	CD28	IL7R	0.846875455	1.60E-51
PAAD	IUPHAR	CD28	CCR5	0.856363876	7.68E-54
PAAD	IUPHAR	CD28	ITGA4	0.857046798	5.15E-54
PAAD	IUPHAR	CD28	MAP4K1	0.858914142	1.71E-54
PAAD	IUPHAR	CD28	CD2	0.862632375	1.82E-55
PAAD	IUPHAR	CD28	CSF2RB	0.864993458	4.25E-56
PAAD	IUPHAR	CD28	GPR171	0.865206539	3.72E-56
PAAD	IUPHAR	CD28	BTK	0.871963864	4.87E-58
PAAD	IUPHAR	CD28	CD3E	0.872295825	3.91E-58
PAAD	IUPHAR	CD28	PYHIN1	0.876619133	2.13E-59
PAAD	IUPHAR	CD28	ICOS	0.877509148	1.15E-59
PAAD	IUPHAR	CD28	ITGAL	0.878269396	6.79E-60
PAAD	IUPHAR	CD28	IL10RA	0.87952722	2.81E-60
PAAD	IUPHAR	CD28	CCR7	0.88107114	9.42E-61
PAAD	IUPHAR	CD28	PRKCB	0.883539204	1.59E-61
PAAD	IUPHAR	CD28	TIGIT	0.88940677	1.94E-63
PAAD	IUPHAR	CD28	CCR4	0.897151204	3.90E-66
PAAD	IUPHAR	CD28	ITK	0.899587916	4.99E-67
PAAD	IUPHAR	CD28	P2RY10	0.905831192	2.00E-69
PAAD	IUPHAR	CD28	PTPRC	0.914840334	3.39E-73
PAAD	Kinase	CD28	PRKCH	0.815763788	6.62E-45
PAAD	Kinase	CD28	MAP4K1	0.858914142	1.71E-54
PAAD	Kinase	CD28	BTK	0.871963864	4.87E-58
PAAD	Kinase	CD28	PRKCB	0.883539204	1.59E-61
PAAD	Kinase	CD28	ITK	0.899587916	4.99E-67
PAAD	TF	CD28	ZNF80	0.80063494	4.00E-42
PAAD	TF	CD28	SP140	0.804897854	6.97E-43
PAAD	TF	CD28	EOMES	0.805992663	4.42E-43
PAAD	TF	CD28	MEF2C	0.809435262	1.03E-43
PAAD	TF	CD28	IKZF3	0.814041747	1.41E-44
PAAD	TF	CD28	FOXP3	0.818781269	1.72E-45
PAAD	TF	CD28	POU2F2	0.821376948	5.29E-46
PAAD	TF	CD28	IRF4	0.851933463	9.72E-53
PAAD	TF	CD28	FLI1	0.857523438	3.90E-54
PAAD	TF	CD28	IKZF1	0.915621503	1.53E-73
PAAD	TSG	CD28	IKZF3	0.814041747	1.41E-44
PAAD	TSG	CD28	CD4	0.814891443	9.73E-45
PAAD	TSG	CD28	FOXP3	0.818781269	1.72E-45
PAAD	TSG	CD28	RASSF2	0.849458715	3.87E-52
PAAD	TSG	CD28	IRF4	0.851933463	9.72E-53
PAAD	TSG	CD28	MAP4K1	0.858914142	1.71E-54
PAAD	TSG	CD28	BTK	0.871963864	4.87E-58
PAAD	TSG	CD28	PYHIN1	0.876619133	2.13E-59
PAAD	TSG	CD28	PRKCB	0.883539204	1.59E-61
PAAD	TSG	CD28	PTPRC	0.914840334	3.39E-73
PAAD	TSG	CD28	IKZF1	0.915621503	1.53E-73
READ	Cell metabolism gene	CD28	PIK3CG	0.821757975	6.61E-27
READ	Cell metabolism gene	CD28	PIK3R5	0.837204761	9.41E-29
READ	CGC	CD28	LCP1	0.805842792	3.51E-25
READ	CGC	CD28	P2RY8	0.808125518	2.03E-25
READ	CGC	CD28	RHOH	0.813999647	4.80E-26
READ	CGC	CD28	BTK	0.823593576	4.07E-27
READ	CGC	CD28	FLI1	0.82641989	1.91E-27
READ	CGC	CD28	CCR4	0.836485998	1.16E-28
READ	CGC	CD28	ITK	0.87236114	8.68E-34
READ	CGC	CD28	IKZF1	0.891135572	3.93E-37
READ	CGC	CD28	PTPRC	0.917711235	4.31E-43
READ	Epifactor	CD28	SFMBT2	0.805344079	3.95E-25
READ	Epifactor	CD28	IKZF1	0.891135572	3.93E-37
READ	IUPHAR	CD28	CD86	0.801432868	9.88E-25
READ	IUPHAR	CD28	CCR5	0.805596224	3.72E-25
READ	IUPHAR	CD28	CLEC7A	0.807196039	2.54E-25
READ	IUPHAR	CD28	P2RY8	0.808125518	2.03E-25
READ	IUPHAR	CD28	KCNA3	0.814891274	3.84E-26
READ	IUPHAR	CD28	PYHIN1	0.819220627	1.28E-26
READ	IUPHAR	CD28	ICOS	0.819700795	1.13E-26
READ	IUPHAR	CD28	IL10RA	0.8207818	8.53E-27
READ	IUPHAR	CD28	PIK3CG	0.821757975	6.61E-27
READ	IUPHAR	CD28	CYBB	0.823004047	4.76E-27
READ	IUPHAR	CD28	CSF2RB	0.82344475	4.24E-27
READ	IUPHAR	CD28	BTK	0.823593576	4.07E-27
READ	IUPHAR	CD28	IL2RB	0.824684148	3.05E-27
READ	IUPHAR	CD28	CCR4	0.836485998	1.16E-28
READ	IUPHAR	CD28	PIK3R5	0.837204761	9.41E-29
READ	IUPHAR	CD28	P2RY10	0.83760842	8.37E-29
READ	IUPHAR	CD28	TLR8	0.840734493	3.35E-29
READ	IUPHAR	CD28	ITGAL	0.840918928	3.17E-29
READ	IUPHAR	CD28	CD4	0.846686328	5.52E-30
READ	IUPHAR	CD28	ITGA4	0.846690821	5.51E-30
READ	IUPHAR	CD28	GPR65	0.853739601	5.89E-31
READ	IUPHAR	CD28	ITK	0.87236114	8.68E-34
READ	IUPHAR	CD28	PTPRC	0.917711235	4.31E-43
READ	Kinase	CD28	BTK	0.823593576	4.07E-27
READ	Kinase	CD28	ITK	0.87236114	8.68E-34
READ	TF	CD28	FLI1	0.82641989	1.91E-27
READ	TF	CD28	ZNF831	0.828137022	1.20E-27
READ	TF	CD28	IKZF1	0.891135572	3.93E-37
READ	TSG	CD28	PLXNC1	0.804061207	5.35E-25
READ	TSG	CD28	RASSF2	0.817841883	1.82E-26
READ	TSG	CD28	PYHIN1	0.819220627	1.28E-26
READ	TSG	CD28	BTK	0.823593576	4.07E-27
READ	TSG	CD28	CD4	0.846686328	5.52E-30
READ	TSG	CD28	IKZF1	0.891135572	3.93E-37
READ	TSG	CD28	PTPRC	0.917711235	4.31E-43
SKCM	CGC	CD28	P2RY8	0.801548925	1.73E-107
SKCM	CGC	CD28	FLI1	0.805249342	3.30E-109
SKCM	CGC	CD28	VAV1	0.811577685	3.07E-112
SKCM	CGC	CD28	IKZF1	0.831522763	1.35E-122
SKCM	CGC	CD28	PTPRC	0.851158709	3.26E-134
SKCM	Epifactor	CD28	IKZF1	0.831522763	1.35E-122
SKCM	IUPHAR	CD28	P2RY8	0.801548925	1.73E-107
SKCM	IUPHAR	CD28	GPR65	0.801852873	1.26E-107
SKCM	IUPHAR	CD28	CYBB	0.803479704	2.22E-108
SKCM	IUPHAR	CD28	INPP5D	0.806989454	4.97E-110
SKCM	IUPHAR	CD28	IL10RA	0.806996332	4.93E-110
SKCM	IUPHAR	CD28	P2RY10	0.810477122	1.05E-111
SKCM	IUPHAR	CD28	CSF2RB	0.812160357	1.60E-112
SKCM	IUPHAR	CD28	CYSLTR1	0.815218475	4.92E-114
SKCM	IUPHAR	CD28	LILRB1	0.817508657	3.48E-115
SKCM	IUPHAR	CD28	PTPRC	0.851158709	3.26E-134
SKCM	TF	CD28	FLI1	0.805249342	3.30E-109
SKCM	TF	CD28	IKZF1	0.831522763	1.35E-122
SKCM	TF	CD28	IRF8	0.838475048	1.58E-126
SKCM	TSG	CD28	IKZF1	0.831522763	1.35E-122
SKCM	TSG	CD28	IRF8	0.838475048	1.58E-126
SKCM	TSG	CD28	LRMP	0.844035766	8.19E-130
SKCM	TSG	CD28	PTPRC	0.851158709	3.26E-134
STAD	Cell metabolism gene	CD28	PIK3R5	0.832222081	8.00E-117
STAD	Cell metabolism gene	CD28	PIK3CG	0.834599807	4.36E-118
STAD	CGC	CD28	WAS	0.809530486	1.10E-105
STAD	CGC	CD28	P2RY8	0.814222309	7.35E-108
STAD	CGC	CD28	FLI1	0.819595788	1.98E-110
STAD	CGC	CD28	ITK	0.8348723	3.11E-118
STAD	CGC	CD28	CCR4	0.837731643	8.79E-120
STAD	CGC	CD28	LCP1	0.842257532	2.69E-122
STAD	CGC	CD28	BTK	0.854768278	1.10E-129
STAD	CGC	CD28	IKZF1	0.898902483	1.17E-162
STAD	CGC	CD28	PTPRC	0.900800648	2.09E-164
STAD	Epifactor	CD28	IKZF1	0.898902483	1.17E-162
STAD	IUPHAR	CD28	TLR7	0.805182239	1.02E-103
STAD	IUPHAR	CD28	LILRB1	0.806850156	1.82E-104
STAD	IUPHAR	CD28	GZMK	0.808787521	2.41E-105
STAD	IUPHAR	CD28	CSF2RB	0.811118465	2.06E-106
STAD	IUPHAR	CD28	P2RY8	0.814222309	7.35E-108
STAD	IUPHAR	CD28	KCNA3	0.820159363	1.05E-110
STAD	IUPHAR	CD28	PYHIN1	0.827590658	2.03E-114
STAD	IUPHAR	CD28	CD4	0.830481013	6.54E-116
STAD	IUPHAR	CD28	PIK3R5	0.832222081	8.00E-117
STAD	IUPHAR	CD28	GPR65	0.832266638	7.58E-117
STAD	IUPHAR	CD28	PIK3CG	0.834599807	4.36E-118
STAD	IUPHAR	CD28	ITK	0.8348723	3.11E-118
STAD	IUPHAR	CD28	CCR4	0.837731643	8.79E-120
STAD	IUPHAR	CD28	P2RY10	0.853968346	3.43E-129
STAD	IUPHAR	CD28	BTK	0.854768278	1.10E-129
STAD	IUPHAR	CD28	ITGAL	0.856422913	1.03E-130
STAD	IUPHAR	CD28	IL10RA	0.857964655	1.11E-131
STAD	IUPHAR	CD28	ITGA4	0.859837641	7.07E-133
STAD	IUPHAR	CD28	PTPRC	0.900800648	2.09E-164
STAD	Kinase	CD28	ITK	0.8348723	3.11E-118
STAD	Kinase	CD28	BTK	0.854768278	1.10E-129
STAD	TF	CD28	ZNF831	0.812688057	3.84E-107
STAD	TF	CD28	FLI1	0.819595788	1.98E-110
STAD	TF	CD28	IKZF1	0.898902483	1.17E-162
STAD	TSG	CD28	PYHIN1	0.827590658	2.03E-114
STAD	TSG	CD28	CD4	0.830481013	6.54E-116
STAD	TSG	CD28	BTK	0.854768278	1.10E-129
STAD	TSG	CD28	IKZF1	0.898902483	1.17E-162
STAD	TSG	CD28	PTPRC	0.900800648	2.09E-164
TGCT	Cell metabolism gene	CD28	PLA2G2D	0.808428722	2.82E-37
TGCT	CGC	CD28	JAK3	0.800932591	3.97E-36
TGCT	CGC	CD28	BTK	0.810922469	1.14E-37
TGCT	CGC	CD28	ITK	0.81144357	9.41E-38
TGCT	CGC	CD28	PRKCB	0.811461763	9.35E-38
TGCT	CGC	CD28	RHOH	0.82127857	2.28E-39
TGCT	CGC	CD28	CIITA	0.825101051	5.05E-40
TGCT	CGC	CD28	IL21R	0.83360758	1.54E-41
TGCT	CGC	CD28	BIRC3	0.847157285	3.86E-44
TGCT	CGC	CD28	WAS	0.849043856	1.60E-44
TGCT	CGC	CD28	P2RY8	0.863292564	1.37E-47
TGCT	CGC	CD28	PTPRC	0.888700539	5.04E-54
TGCT	CGC	CD28	IKZF1	0.908612309	2.83E-60
TGCT	Epifactor	CD28	PRKCB	0.811461763	9.35E-38
TGCT	Epifactor	CD28	GFI1	0.851668504	4.61E-45
TGCT	Epifactor	CD28	IKZF1	0.908612309	2.83E-60
TGCT	IUPHAR	CD28	CTSS	0.800253176	5.02E-36
TGCT	IUPHAR	CD28	JAK3	0.800932591	3.97E-36
TGCT	IUPHAR	CD28	IL2RG	0.801896664	2.84E-36
TGCT	IUPHAR	CD28	CD86	0.802707277	2.14E-36
TGCT	IUPHAR	CD28	TLR6	0.802819553	2.06E-36
TGCT	IUPHAR	CD28	GZMK	0.802868204	2.03E-36
TGCT	IUPHAR	CD28	IL2RA	0.804355265	1.20E-36
TGCT	IUPHAR	CD28	TNFRSF1B	0.80475225	1.05E-36
TGCT	IUPHAR	CD28	CXCR3	0.805486538	8.07E-37
TGCT	IUPHAR	CD28	PLA2G2D	0.808428722	2.82E-37
TGCT	IUPHAR	CD28	BTK	0.810922469	1.14E-37
TGCT	IUPHAR	CD28	ITK	0.81144357	9.41E-38
TGCT	IUPHAR	CD28	PRKCB	0.811461763	9.35E-38
TGCT	IUPHAR	CD28	MCOLN2	0.812015917	7.63E-38
TGCT	IUPHAR	CD28	CD2	0.822211352	1.58E-39
TGCT	IUPHAR	CD28	CIITA	0.825101051	5.05E-40
TGCT	IUPHAR	CD28	GPR18	0.827657683	1.80E-40
TGCT	IUPHAR	CD28	PTGER4	0.828410691	1.33E-40
TGCT	IUPHAR	CD28	PYHIN1	0.829009402	1.04E-40
TGCT	IUPHAR	CD28	CXCR6	0.832011542	3.01E-41
TGCT	IUPHAR	CD28	P2RY13	0.832549655	2.40E-41
TGCT	IUPHAR	CD28	IL21R	0.83360758	1.54E-41
TGCT	IUPHAR	CD28	NLRC5	0.834745864	9.50E-42
TGCT	IUPHAR	CD28	LILRB1	0.835014819	8.47E-42
TGCT	IUPHAR	CD28	AIM2	0.835937292	5.71E-42
TGCT	IUPHAR	CD28	IL2RB	0.837153383	3.39E-42
TGCT	IUPHAR	CD28	CD3E	0.838910838	1.58E-42
TGCT	IUPHAR	CD28	CD4	0.840369456	8.31E-43
TGCT	IUPHAR	CD28	IL12RB1	0.840812389	6.83E-43
TGCT	IUPHAR	CD28	P2RY10	0.841141107	5.90E-43
TGCT	IUPHAR	CD28	NLRC3	0.841541666	4.94E-43
TGCT	IUPHAR	CD28	CCR5	0.84300982	2.56E-43
TGCT	IUPHAR	CD28	GPR171	0.844591383	1.25E-43
TGCT	IUPHAR	CD28	GPR65	0.846057295	6.40E-44
TGCT	IUPHAR	CD28	CD6	0.846069774	6.37E-44
TGCT	IUPHAR	CD28	CD247	0.846740384	4.68E-44
TGCT	IUPHAR	CD28	BIRC3	0.847157285	3.86E-44
TGCT	IUPHAR	CD28	CD37	0.862487367	2.09E-47
TGCT	IUPHAR	CD28	P2RY8	0.863292564	1.37E-47
TGCT	IUPHAR	CD28	IL10RA	0.864729845	6.45E-48
TGCT	IUPHAR	CD28	ITGAL	0.868174054	1.02E-48
TGCT	IUPHAR	CD28	PTPN22	0.86890295	6.83E-49
TGCT	IUPHAR	CD28	CSF2RB	0.872132534	1.14E-49
TGCT	IUPHAR	CD28	PTPRC	0.888700539	5.04E-54
TGCT	Kinase	CD28	JAK3	0.800932591	3.97E-36
TGCT	Kinase	CD28	BTK	0.810922469	1.14E-37
TGCT	Kinase	CD28	ITK	0.81144357	9.41E-38
TGCT	Kinase	CD28	PRKCB	0.811461763	9.35E-38
TGCT	TF	CD28	TBX21	0.811387048	9.61E-38
TGCT	TF	CD28	GFI1	0.851668504	4.61E-45
TGCT	TF	CD28	RUNX3	0.856817361	3.74E-46
TGCT	TF	CD28	ZNF831	0.878397934	3.06E-51
TGCT	TF	CD28	IKZF1	0.908612309	2.83E-60
TGCT	TSG	CD28	TNFAIP8L2	0.800722791	4.27E-36
TGCT	TSG	CD28	BTK	0.810922469	1.14E-37
TGCT	TSG	CD28	PRKCB	0.811461763	9.35E-38
TGCT	TSG	CD28	DENND2D	0.825654037	4.05E-40
TGCT	TSG	CD28	PYHIN1	0.829009402	1.04E-40
TGCT	TSG	CD28	AIM2	0.835937292	5.71E-42
TGCT	TSG	CD28	RASSF5	0.839776173	1.08E-42
TGCT	TSG	CD28	CD4	0.840369456	8.31E-43
TGCT	TSG	CD28	RUNX3	0.856817361	3.74E-46
TGCT	TSG	CD28	PTPRC	0.888700539	5.04E-54
TGCT	TSG	CD28	IKZF1	0.908612309	2.83E-60
THCA	Cell metabolism gene	CD28	PDE3B	0.814513219	6.74E-137
THCA	Cell metabolism gene	CD28	PLA2G2D	0.826975752	1.15E-144
THCA	Cell metabolism gene	CD28	PIK3R5	0.845220129	3.08E-157
THCA	CGC	CD28	CIITA	0.806798506	2.23E-132
THCA	CGC	CD28	CD79A	0.819830843	3.87E-140
THCA	CGC	CD28	VAV1	0.828668725	9.06E-146
THCA	CGC	CD28	BIRC3	0.830176511	9.21E-147
THCA	CGC	CD28	LCK	0.832102477	4.80E-148
THCA	CGC	CD28	CCR4	0.835468536	2.51E-150
THCA	CGC	CD28	IL21R	0.839229673	6.16E-153
THCA	CGC	CD28	LCP1	0.845288606	2.75E-157
THCA	CGC	CD28	WAS	0.856063695	1.65E-165
THCA	CGC	CD28	FLT3	0.861761071	3.95E-170
THCA	CGC	CD28	BTK	0.867419445	6.25E-175
THCA	CGC	CD28	ITK	0.874279385	4.68E-181
THCA	CGC	CD28	CCR7	0.8780144	1.52E-184
THCA	CGC	CD28	RHOH	0.883032664	2.04E-189
THCA	CGC	CD28	IKZF1	0.901497756	1.75E-209
THCA	CGC	CD28	PTPRC	0.90579086	1.01E-214
THCA	Epifactor	CD28	GFI1	0.812657638	8.61E-136
THCA	Epifactor	CD28	SP140	0.893058534	7.43E-200
THCA	Epifactor	CD28	IKZF1	0.901497756	1.75E-209
THCA	IUPHAR	CD28	ADAM19	0.800423323	8.57E-129
THCA	IUPHAR	CD28	HAVCR2	0.802106894	9.99E-130
THCA	IUPHAR	CD28	CIITA	0.806798506	2.23E-132
THCA	IUPHAR	CD28	CD4	0.807196327	1.32E-132
THCA	IUPHAR	CD28	TLR6	0.807926263	5.02E-133
THCA	IUPHAR	CD28	ITGA4	0.809765757	4.31E-134
THCA	IUPHAR	CD28	NCR3	0.810279159	2.16E-134
THCA	IUPHAR	CD28	TLR8	0.810468045	1.68E-134
THCA	IUPHAR	CD28	CXCR5	0.811780738	2.84E-135
THCA	IUPHAR	CD28	GPR65	0.812890575	6.26E-136
THCA	IUPHAR	CD28	CD6	0.813597591	2.38E-136
THCA	IUPHAR	CD28	TNFRSF13B	0.813849285	1.68E-136
THCA	IUPHAR	CD28	CCR5	0.814030887	1.31E-136
THCA	IUPHAR	CD28	IL2RA	0.814464875	7.20E-137
THCA	IUPHAR	CD28	PDE3B	0.814513219	6.74E-137
THCA	IUPHAR	CD28	IL10RA	0.817243083	1.51E-138
THCA	IUPHAR	CD28	CD52	0.817384064	1.24E-138
THCA	IUPHAR	CD28	IL2RB	0.818532389	2.45E-139
THCA	IUPHAR	CD28	GPR171	0.820480247	1.53E-140
THCA	IUPHAR	CD28	NOD2	0.821059843	6.66E-141
THCA	IUPHAR	CD28	HCK	0.821995408	1.73E-141
THCA	IUPHAR	CD28	ZAP70	0.824342252	5.66E-143
THCA	IUPHAR	CD28	ITGB2	0.824844876	2.70E-143
THCA	IUPHAR	CD28	PLA2G2D	0.826975752	1.15E-144
THCA	IUPHAR	CD28	BIRC3	0.830176511	9.21E-147
THCA	IUPHAR	CD28	LCK	0.832102477	4.80E-148
THCA	IUPHAR	CD28	TLR10	0.832465188	2.74E-148
THCA	IUPHAR	CD28	CD86	0.832533536	2.47E-148
THCA	IUPHAR	CD28	CCR4	0.835468536	2.51E-150
THCA	IUPHAR	CD28	CYBB	0.837494907	1.00E-151
THCA	IUPHAR	CD28	IL21R	0.839229673	6.16E-153
THCA	IUPHAR	CD28	FPR3	0.840601391	6.61E-154
THCA	IUPHAR	CD28	GZMK	0.842080843	5.82E-155
THCA	IUPHAR	CD28	PIK3R5	0.845220129	3.08E-157
THCA	IUPHAR	CD28	SLAMF7	0.845409955	2.24E-157
THCA	IUPHAR	CD28	PYHIN1	0.849505224	1.99E-160
THCA	IUPHAR	CD28	AIM2	0.852714237	6.98E-163
THCA	IUPHAR	CD28	CD247	0.853919277	8.07E-164
THCA	IUPHAR	CD28	CD2	0.853986964	7.15E-164
THCA	IUPHAR	CD28	IL12RB1	0.855982299	1.92E-165
THCA	IUPHAR	CD28	CD3E	0.859474744	2.99E-168
THCA	IUPHAR	CD28	FLT3	0.861761071	3.95E-170
THCA	IUPHAR	CD28	CSF2RB	0.866985922	1.48E-174
THCA	IUPHAR	CD28	CTLA4	0.867165895	1.04E-174
THCA	IUPHAR	CD28	BTK	0.867419445	6.25E-175
THCA	IUPHAR	CD28	CD37	0.868618014	5.63E-176
THCA	IUPHAR	CD28	ITGAL	0.873596889	1.98E-180
THCA	IUPHAR	CD28	ITK	0.874279385	4.68E-181
THCA	IUPHAR	CD28	TNFRSF9	0.874802365	1.54E-181
THCA	IUPHAR	CD28	CCR7	0.8780144	1.52E-184
THCA	IUPHAR	CD28	PTPN22	0.87938236	7.51E-186
THCA	IUPHAR	CD28	IL2RG	0.88873973	3.10E-195
THCA	IUPHAR	CD28	SP140	0.893058534	7.43E-200
THCA	IUPHAR	CD28	ICOS	0.894930517	6.41E-202
THCA	IUPHAR	CD28	P2RY10	0.90428711	7.37E-213
THCA	IUPHAR	CD28	PTPRC	0.90579086	1.01E-214
THCA	IUPHAR	CD28	TIGIT	0.909006977	8.18E-219
THCA	Kinase	CD28	HCK	0.821995408	1.73E-141
THCA	Kinase	CD28	ZAP70	0.824342252	5.66E-143
THCA	Kinase	CD28	LCK	0.832102477	4.80E-148
THCA	Kinase	CD28	FLT3	0.861761071	3.95E-170
THCA	Kinase	CD28	BTK	0.867419445	6.25E-175
THCA	Kinase	CD28	ITK	0.874279385	4.68E-181
THCA	TF	CD28	TFEC	0.811897472	2.42E-135
THCA	TF	CD28	GFI1	0.812657638	8.61E-136
THCA	TF	CD28	POU2F2	0.818356216	3.14E-139
THCA	TF	CD28	BATF	0.827874363	2.99E-145
THCA	TF	CD28	ZNF831	0.841420079	1.73E-154
THCA	TF	CD28	SPIB	0.849179132	3.51E-160
THCA	TF	CD28	IRF8	0.878791256	2.77E-185
THCA	TF	CD28	RUNX3	0.891727788	2.07E-198
THCA	TF	CD28	SP140	0.893058534	7.43E-200
THCA	TF	CD28	IKZF1	0.901497756	1.75E-209
THCA	TSG	CD28	CXCL10	0.806917309	1.91E-132
THCA	TSG	CD28	CD4	0.807196327	1.32E-132
THCA	TSG	CD28	DOK2	0.83436441	1.43E-149
THCA	TSG	CD28	PYHIN1	0.849505224	1.99E-160
THCA	TSG	CD28	AIM2	0.852714237	6.98E-163
THCA	TSG	CD28	FLT3	0.861761071	3.95E-170
THCA	TSG	CD28	BTK	0.867419445	6.25E-175
THCA	TSG	CD28	IRF8	0.878791256	2.77E-185
THCA	TSG	CD28	RUNX3	0.891727788	2.07E-198
THCA	TSG	CD28	IKZF1	0.901497756	1.75E-209
THCA	TSG	CD28	PTPRC	0.90579086	1.01E-214
THYM	Cell metabolism gene	CD28	NUP210	0.815892874	2.50E-30
THYM	Cell metabolism gene	CD28	CD38	0.817833261	1.41E-30
THYM	Cell metabolism gene	CD28	DGKA	0.81909088	9.67E-31
THYM	Cell metabolism gene	CD28	PIP4K2A	0.843009816	4.15E-34
THYM	Cell metabolism gene	CD28	GNG2	0.868096359	2.64E-38
THYM	CGC	CD28	LCP1	0.80113031	1.59E-28
THYM	CGC	CD28	BCL11B	0.805923645	4.30E-29
THYM	CGC	CD28	FLI1	0.810983022	1.04E-29
THYM	CGC	CD28	LCK	0.817820227	1.41E-30
THYM	CGC	CD28	CXCR4	0.819098434	9.64E-31
THYM	CGC	CD28	LEPROTL1	0.820115812	7.10E-31
THYM	CGC	CD28	WAS	0.822325977	3.63E-31
THYM	CGC	CD28	FNBP1	0.830892413	2.45E-32
THYM	CGC	CD28	P2RY8	0.840704344	9.26E-34
THYM	CGC	CD28	RHOH	0.853763123	8.23E-36
THYM	CGC	CD28	PRKCB	0.87279131	3.47E-39
THYM	CGC	CD28	IKZF1	0.879502327	1.65E-40
THYM	CGC	CD28	ITK	0.880074172	1.26E-40
THYM	Epifactor	CD28	MSL3	0.802805735	1.01E-28
THYM	Epifactor	CD28	GFI1	0.81898009	9.99E-31
THYM	Epifactor	CD28	PRKCB	0.87279131	3.47E-39
THYM	Epifactor	CD28	IKZF1	0.879502327	1.65E-40
THYM	IUPHAR	CD28	PRKCQ	0.800626295	1.83E-28
THYM	IUPHAR	CD28	CAMK4	0.808457787	2.12E-29
THYM	IUPHAR	CD28	PVRIG	0.811812857	8.17E-30
THYM	IUPHAR	CD28	LCK	0.817820227	1.41E-30
THYM	IUPHAR	CD28	CD38	0.817833261	1.41E-30
THYM	IUPHAR	CD28	CXCR4	0.819098434	9.64E-31
THYM	IUPHAR	CD28	GRK6	0.82077636	5.82E-31
THYM	IUPHAR	CD28	PTPN22	0.82161346	4.51E-31
THYM	IUPHAR	CD28	FYN	0.830044335	3.23E-32
THYM	IUPHAR	CD28	KCNA3	0.832039011	1.69E-32
THYM	IUPHAR	CD28	CD4	0.832770912	1.33E-32
THYM	IUPHAR	CD28	SEMA4D	0.834744084	6.96E-33
THYM	IUPHAR	CD28	PDCD1	0.83524595	5.89E-33
THYM	IUPHAR	CD28	P2RY8	0.840704344	9.26E-34
THYM	IUPHAR	CD28	PIP4K2A	0.843009816	4.15E-34
THYM	IUPHAR	CD28	CD52	0.844808168	2.20E-34
THYM	IUPHAR	CD28	CD2	0.846560216	1.18E-34
THYM	IUPHAR	CD28	CD37	0.847142765	9.53E-35
THYM	IUPHAR	CD28	IL2RG	0.847193174	9.36E-35
THYM	IUPHAR	CD28	CD3E	0.860801556	5.31E-37
THYM	IUPHAR	CD28	MAP4K1	0.860930253	5.05E-37
THYM	IUPHAR	CD28	CD6	0.861017207	4.87E-37
THYM	IUPHAR	CD28	CD247	0.864679248	1.10E-37
THYM	IUPHAR	CD28	PRKCB	0.87279131	3.47E-39
THYM	IUPHAR	CD28	ITGAL	0.877148381	4.90E-40
THYM	IUPHAR	CD28	ITK	0.880074172	1.26E-40
THYM	IUPHAR	CD28	NLRC3	0.880798489	8.97E-41
THYM	IUPHAR	CD28	RASGRP1	0.889690519	1.13E-42
THYM	IUPHAR	CD28	ICOS	0.892139702	3.15E-43
THYM	Kinase	CD28	PRKCQ	0.800626295	1.83E-28
THYM	Kinase	CD28	CAMK4	0.808457787	2.12E-29
THYM	Kinase	CD28	LCK	0.817820227	1.41E-30
THYM	Kinase	CD28	GRK6	0.82077636	5.82E-31
THYM	Kinase	CD28	FYN	0.830044335	3.23E-32
THYM	Kinase	CD28	MAP4K1	0.860930253	5.05E-37
THYM	Kinase	CD28	PRKCB	0.87279131	3.47E-39
THYM	Kinase	CD28	ITK	0.880074172	1.26E-40
THYM	TF	CD28	ZNF101	0.802258765	1.18E-28
THYM	TF	CD28	BCL11B	0.805923645	4.30E-29
THYM	TF	CD28	FLI1	0.810983022	1.04E-29
THYM	TF	CD28	GFI1	0.81898009	9.99E-31
THYM	TF	CD28	AKNA	0.867064317	4.08E-38
THYM	TF	CD28	HSF5	0.87345856	2.58E-39
THYM	TF	CD28	IKZF1	0.879502327	1.65E-40
THYM	TSG	CD28	RASSF5	0.813990325	4.36E-30
THYM	TSG	CD28	CD4	0.832770912	1.33E-32
THYM	TSG	CD28	MAP4K1	0.860930253	5.05E-37
THYM	TSG	CD28	PRKCB	0.87279131	3.47E-39
THYM	TSG	CD28	IKZF1	0.879502327	1.65E-40
UCS	Cell metabolism gene	CD28	NUP210	0.815892874	2.50E-30
UCS	Cell metabolism gene	CD28	CD38	0.817833261	1.41E-30
UCS	Cell metabolism gene	CD28	DGKA	0.81909088	9.67E-31
UCS	Cell metabolism gene	CD28	PIP4K2A	0.843009816	4.15E-34
UCS	Cell metabolism gene	CD28	GNG2	0.868096359	2.64E-38
UCS	CGC	CD28	LCP1	0.80113031	1.59E-28
UCS	CGC	CD28	BCL11B	0.805923645	4.30E-29
UCS	CGC	CD28	FLI1	0.810983022	1.04E-29
UCS	CGC	CD28	LCK	0.817820227	1.41E-30
UCS	CGC	CD28	CXCR4	0.819098434	9.64E-31
UCS	CGC	CD28	LEPROTL1	0.820115812	7.10E-31
UCS	CGC	CD28	WAS	0.822325977	3.63E-31
UCS	CGC	CD28	FNBP1	0.830892413	2.45E-32
UCS	CGC	CD28	P2RY8	0.840704344	9.26E-34
UCS	CGC	CD28	RHOH	0.853763123	8.23E-36
UCS	CGC	CD28	PRKCB	0.87279131	3.47E-39
UCS	CGC	CD28	IKZF1	0.879502327	1.65E-40
UCS	CGC	CD28	ITK	0.880074172	1.26E-40
UCS	Epifactor	CD28	MSL3	0.802805735	1.01E-28
UCS	Epifactor	CD28	GFI1	0.81898009	9.99E-31
UCS	Epifactor	CD28	PRKCB	0.87279131	3.47E-39
UCS	Epifactor	CD28	IKZF1	0.879502327	1.65E-40
UCS	IUPHAR	CD28	PRKCQ	0.800626295	1.83E-28
UCS	IUPHAR	CD28	CAMK4	0.808457787	2.12E-29
UCS	IUPHAR	CD28	PVRIG	0.811812857	8.17E-30
UCS	IUPHAR	CD28	LCK	0.817820227	1.41E-30
UCS	IUPHAR	CD28	CD38	0.817833261	1.41E-30
UCS	IUPHAR	CD28	CXCR4	0.819098434	9.64E-31
UCS	IUPHAR	CD28	GRK6	0.82077636	5.82E-31
UCS	IUPHAR	CD28	PTPN22	0.82161346	4.51E-31
UCS	IUPHAR	CD28	FYN	0.830044335	3.23E-32
UCS	IUPHAR	CD28	KCNA3	0.832039011	1.69E-32
UCS	IUPHAR	CD28	CD4	0.832770912	1.33E-32
UCS	IUPHAR	CD28	SEMA4D	0.834744084	6.96E-33
UCS	IUPHAR	CD28	PDCD1	0.83524595	5.89E-33
UCS	IUPHAR	CD28	P2RY8	0.840704344	9.26E-34
UCS	IUPHAR	CD28	PIP4K2A	0.843009816	4.15E-34
UCS	IUPHAR	CD28	CD52	0.844808168	2.20E-34
UCS	IUPHAR	CD28	CD2	0.846560216	1.18E-34
UCS	IUPHAR	CD28	CD37	0.847142765	9.53E-35
UCS	IUPHAR	CD28	IL2RG	0.847193174	9.36E-35
UCS	IUPHAR	CD28	CD3E	0.860801556	5.31E-37
UCS	IUPHAR	CD28	MAP4K1	0.860930253	5.05E-37
UCS	IUPHAR	CD28	CD6	0.861017207	4.87E-37
UCS	IUPHAR	CD28	CD247	0.864679248	1.10E-37
UCS	IUPHAR	CD28	PRKCB	0.87279131	3.47E-39
UCS	IUPHAR	CD28	ITGAL	0.877148381	4.90E-40
UCS	IUPHAR	CD28	ITK	0.880074172	1.26E-40
UCS	IUPHAR	CD28	NLRC3	0.880798489	8.97E-41
UCS	IUPHAR	CD28	RASGRP1	0.889690519	1.13E-42
UCS	IUPHAR	CD28	ICOS	0.892139702	3.15E-43
UCS	Kinase	CD28	PRKCQ	0.800626295	1.83E-28
UCS	Kinase	CD28	CAMK4	0.808457787	2.12E-29
UCS	Kinase	CD28	LCK	0.817820227	1.41E-30
UCS	Kinase	CD28	GRK6	0.82077636	5.82E-31
UCS	Kinase	CD28	FYN	0.830044335	3.23E-32
UCS	Kinase	CD28	MAP4K1	0.860930253	5.05E-37
UCS	Kinase	CD28	PRKCB	0.87279131	3.47E-39
UCS	Kinase	CD28	ITK	0.880074172	1.26E-40
UCS	TF	CD28	ZNF101	0.802258765	1.18E-28
UCS	TF	CD28	BCL11B	0.805923645	4.30E-29
UCS	TF	CD28	FLI1	0.810983022	1.04E-29
UCS	TF	CD28	GFI1	0.81898009	9.99E-31
UCS	TF	CD28	AKNA	0.867064317	4.08E-38
UCS	TF	CD28	HSF5	0.87345856	2.58E-39
UCS	TF	CD28	IKZF1	0.879502327	1.65E-40
UCS	TSG	CD28	RASSF5	0.813990325	4.36E-30
UCS	TSG	CD28	CD4	0.832770912	1.33E-32
UCS	TSG	CD28	MAP4K1	0.860930253	5.05E-37
UCS	TSG	CD28	PRKCB	0.87279131	3.47E-39
UCS	TSG	CD28	IKZF1	0.879502327	1.65E-40

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	CD28	PRKCQ	1.1213411435253	0.000104279746966409
LUSC	CD28	CD2	-1.64189699341398	0.000155452205994213
KIRC	CD28	GRB2	-3.50962289529079	0.000210123708729258
PRAD	CD28	PRKCQ	1.04096641487537	0.000246823037914342
LIHC	CD28	GRB2	-2.6070669266439	0.000329386776931513
LIHC	CD28	PIK3R1	-1.64002418254144	0.000410717093526247
LUSC	CD28	GRB2	-1.60175668402919	0.00116257561090457
KICH	CD28	CD247	-1.6943445904132	0.00162535905838013
COAD	CD28	CD247	-5.95306503840925	0.00177955627441406
ESCA	CD28	CD247	-2.45460482449658	0.0029296875
KIRP	CD28	CD2	-2.42037424000409	0.00337919034063816
THCA	CD28	CD4	-1.71153597045417	0.00728983736301066
STAD	CD28	LCK	2.92169517966211	0.00733334058895707
LUSC	CD28	LCK	-1.05268953072542	0.00832415510571246
CHOL	CD28	GRB2	-1.28858368343854	0.01171875
LIHC	CD28	CD80	2.53130025481773	0.0158079482509981
ESCA	CD28	CD86	-2.25141359721692	0.0185546875
THCA	CD28	CD86	-1.07741841419104	0.0194861051261323
COAD	CD28	CD2	-1.71984045205046	0.023610919713974
KIRP	CD28	CD247	-1.28872967763851	0.0265949876047671
BLCA	CD28	CD80	-3.95011351158442	0.0445594787597656
HNSC	CD28	GRB2	-2.71037834855917	1.00141839993739e-05
KIRC	CD28	PRKCQ	-1.52344108477257	1.18743947617303e-11
PRAD	CD28	PIK3R1	-3.75166351498365	1.29626157955309e-06
LUSC	CD28	CD80	-1.31384157244531	1.30806800182817e-08
LUAD	CD28	PRKCQ	-3.38919430947145	1.96297358529593e-10
LUSC	CD28	CD247	-2.43260994915648	2.34762611303971e-07
LUSC	CD28	CD4	-2.27879902122957	2.42825252900713e-09
KICH	CD28	GRB2	1.69470901099239	2.5629997253418e-06
LUSC	CD28	PRKCQ	-3.85476299586165	2.88359523303561e-09
BRCA	CD28	PIK3R1	-1.45536050972386	3.35573160290929e-27
LIHC	CD28	CD4	-4.06430852629026	4.91907449309094e-09
KIRP	CD28	CD80	-1.46799466140014	5.97489997744561e-06
KIRP	CD28	CD86	-6.99023968239804	8.74791294336319e-06
LUSC	CD28	CD86	-1.83503842404547	9.93264690027618e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CD28

CD80, GRAP2, GRB2, Grb2, PIK3R1, DUSP14, PIK3R2, PIK3CA, DOK1, VAV1, PLXDC2, OR56B4, HBA2, LGALS1, YWHAE, YWHAZ, TMEM192, EFNB2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
CD28	chr2	204591408	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CD28	KIRC	chr2	204591400	204591400	G	A	Missense_Mutation	p.D33N	4
CD28	LUAD	chr2	204571325	204571325	T	C	Missense_Mutation	p.S27P	3
CD28	GBM	chr2	204599561	204599561	C	T	Missense_Mutation		3
CD28	ESCA	chr2	204571260	204571260	T	C	Missense_Mutation	p.L5S	2
CD28	HNSC	chr2	204591669	204591669	C	-	Frame_Shift_Del	p.Y122fs	2
CD28	STAD	chr2	204591492	204591492	G	A	Silent		2
CD28	LUAD	chr2	204591409	204591409	G	T	Missense_Mutation	p.V36F	2
CD28	ESCA	chr2	204591394	204591394	G	T	Missense_Mutation	p.A31S	2
CD28	STAD	chr2	204591475	204591475	G	A	Missense_Mutation	p.G58R	2
CD28	ESCA	chr2	204571260	204571260	T	C	Missense_Mutation		2
CD28	SKCM	chr2	204591369	204591369	G	A	Silent	p.L22L	2
CD28	STAD	chr2	204591492	204591492	G	A	Silent	p.V63V	2
CD28	UCEC	chr2	204591673	204591673	G	T	Splice_Site	e3-1	2
CD28	UCEC	chr2	204591686	204591686	G	T	Missense_Mutation	p.S128I	2
CD28	BRCA	chr2	204599579	204599579	C	T	Missense_Mutation	p.R203C	2
CD28	UCEC	chr2	204591705	204591705	T	C	Silent	p.H134	2
CD28	COAD	chr2	204591543	204591543	A	-	Nonsense_Mutation	p.S80X	2
CD28	SKCM	chr2	204591684	204591684	G	A	Silent	p.K43K	2
CD28	LIHC	chr2	204599608	204599608	A	-	Frame_Shift_Del	p.P128fs	2
CD28	BLCA	chr2	204571328	204571328	C	G	Missense_Mutation	p.Q28E	1
CD28	LUAD	chr2	204599581	204599581	C	G	Silent	p.R119R	1
CD28	READ	chr2	204591513	204591513	G	T	Silent	p.G70G	1
CD28	BLCA	chr2	204591658	204591658	C	A	Missense_Mutation	p.P119T	1
CD28	READ	chr2	204599612	204599612	G	A	Missense_Mutation	p.D95N	1
CD28	HNSC	chr2	204594487	204594487	A	T	Missense_Mutation	p.I176F	1
CD28	BLCA	chr2	204571318	204571318	C	T	Silent	p.D24D	1
CD28	KIRC	chr2	204591642	204591644	AAT	-	In_Frame_Del	p.113_114del	1
CD28	BLCA	chr2	204594492	204594492	C	G	Missense_Mutation	p.F177L	1
CD28	LUAD	chr2	204591649	204591649	G	T	Missense_Mutation	p.V116F	1
CD28	ESCA	chr2	204591394	204591394	G	T	Missense_Mutation		1
CD28	SKCM	chr2	204594400	204594400	C	T	Missense_Mutation	p.P28S	1
CD28	STAD	chr2	204571310	204571310	G	A	Translation_Start_Site		1
CD28	STAD	chr2	204591543	204591543	A	-	Frame_Shift_Del	p.S80fs	1
CD28	BLCA	chr2	204594410	204594410	C	T	Missense_Mutation	p.S150F	1
CD28	LUAD	chr2	204591407	204591407	C	T	Missense_Mutation	p.A35V	1
CD28	GBM	chr2	204599561	204599561	C	T	Missense_Mutation	p.R197C	1
CD28	SKCM	chr2	204591684	204591684	G	A	Silent	p.K127K	1
CD28	KIRC	chr2	204591642	204591644	AAT	-	In_Frame_Del	p.KI113del	1
CD28	BLCA	chr2	204591441	204591441	C	T	Silent	p.L46L	1
CD28	LUAD	chr2	204591549	204591549	G	T	Silent	p.T82T	1
CD28	SKCM	chr2	204599511	204599511	G	A	Missense_Mutation	p.R61K	1
CD28	LGG	chr2	204599561	204599561	C	T	Missense_Mutation	p.R78C	1
CD28	LUAD	chr2	204591706	204591706	G	A	Missense_Mutation	p.V51M	1
CD28	HNSC	chr2	204594487	204594487	A	T	Missense_Mutation		1
CD28	SKCM	chr2	204599511	204599511	G	A	Missense_Mutation	p.R96K	1
CD28	BLCA	chr2	204591658	204591658	C	A	Missense_Mutation		1
CD28	LGG	chr2	204599561	204599561	C	T	Missense_Mutation	p.R113C	1
CD28	COAD	chr2	204591474	204591474	A	C	Missense_Mutation	p.K57N	1
CD28	LUAD	chr2	204599581	204599581	C	G	Silent	p.R203R	1
CD28	HNSC	chr2	204571443	204571443	C	T	Silent		1
CD28	SKCM	chr2	204594378	204594378	C	T	Silent	p.H55H	1
CD28	BLCA	chr2	204594492	204594492	C	G	Missense_Mutation		1
CD28	LGG	chr2	204599533	204599533	G	A	Silent	p.L103L	1
CD28	LUSC	chr2	204599596	204599596	C	T	Silent	p.P208P	1
CD28	UCS	chr2	204571286	204571286	G	A	Missense_Mutation	p.G14R	1
CD28	HNSC	chr2	204591669	204591669	C	-	Frame_Shift_Del		1
CD28	SKCM	chr2	204571291	204571291	G	A	Translation_Start_Site		1
CD28	BLCA	chr2	204594410	204594410	C	T	Missense_Mutation		1
CD28	LGG	chr2	204599533	204599533	G	A	Silent		1
CD28	COAD	chr2	204599558	204599558	C	-	Frame_Shift_Del	p.T195fs	1
CD28	PRAD	chr2	204591557	204591557	A	G	Missense_Mutation	p.N85S	1
CD28	HNSC	chr2	204594487	204594487	A	T	Missense_Mutation	p.I92F	1
CD28	BLCA	chr2	204591441	204591441	C	T	Silent		1
CD28	COAD	chr2	204599565	204599565	G	A	Missense_Mutation	p.R79H	1
CD28	PRAD	chr2	204591691	204591691	G	T	Nonsense_Mutation	p.G46*	1
CD28	HNSC	chr2	204571443	204571443	C	T	Silent	p.L8L	1
CD28	SKCM	chr2	204594400	204594400	C	T	Missense_Mutation	p.P63S	1

Copy number variation (CNV) of CD28
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CD28
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
73209	N/A	CR989260	CD28	chr2	204571472	+	KANSL2	chr12	49048845	-
38216	.	.	CTLA4	chr2	204732510	+	CD28	chr2	204732510	+
38216	.	.	CTLA4	chr2	204735308	+	CD28	chr2	204735308	+
38216	.	.	CTLA4	chr2	204736100	+	CD28	chr2	204736100	+
38217	.	.	ICOS	chr2	204801470	+	CD28	chr2	204801470	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BLCA	CD28	0.00273009790487961	0.074
LIHC	CD28	0.0156437835268888	0.41
KIRC	CD28	0.0169775450177685	0.42
GBM	CD28	0.0312566354374287	0.75
SARC	CD28	2.49270429628617e-05	7e-04

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	CD28	0.0321986056219618	0.9
LUAD	CD28	0.0151975767638956	0.44
PRAD	CD28	0.000358169481162355	0.012
SKCM	CD28	0.00633701990191362	0.2
THYM	CD28	0.000372461743760247	0.012
SARC	CD28	0.0102557406613786	0.31

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0003873	Rheumatoid Arthritis	3	CTD_human
C0079773	Lymphoma, T-Cell, Cutaneous	2	CTD_human
C0376407	Granulomatous Slack Skin	2	CTD_human
C0005138	Berylliosis	1	CTD_human
C0023493	Adult T-Cell Lymphoma/Leukemia	1	CTD_human
C0036920	Sezary Syndrome	1	ORPHANET
C0079774	Peripheral T-Cell Lymphoma	1	CTD_human
C0263454	Chloracne	1	CTD_human
C2350873	Beryllium Disease	1	CTD_human
C4505456	HIV Coinfection	1	CTD_human