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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MTRF1 (NCBI Gene ID:9617)

Gene Summary

Gene Summary

Gene Information	Gene Name: MTRF1
	Gene ID: 9617
	Gene Symbol	MTRF1
	Gene ID	9617
	Gene Name	mitochondrial translation release factor 1
	Synonyms	MRF1\|MTTRF1\|RF1
	Cytomap	13q14.11
	Type of Gene	protein-coding
	Description	peptide chain release factor 1, mitochondrialMRF-1mitochondrial translational release factor 1mitochontrial peptide chain release factor 1mtRF-1
	Modification date	20200313
	UniProtAcc	O75570

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006415	Translational termination
GO:0032543	Mitochondrial translation
GO:0008135	Translation factor activity, RNA binding
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MTRF1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MTRF1[title] AND translation [title] AND human.'

Gene	Title	PMID
MTRF1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000379477	41797391	41797490	In-frame
ENST00000379480	41797391	41797490	In-frame
ENST00000379477	41800567	41800704	Frame-shift
ENST00000379480	41800567	41800704	Frame-shift
ENST00000379477	41814396	41814569	Frame-shift
ENST00000379480	41814396	41814569	Frame-shift
ENST00000379477	41835826	41835961	3UTR-3UTR
ENST00000379477	41836350	41836467	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000379477	41797391	41797490	1965	1596	1694	445	375	408
ENST00000379480	41797391	41797490	2202	1227	1325	445	375	408

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
O75570	375	408	407	407	Natural variant	ID=VAR_051789;Note=I->V;Dbxref=dbSNP:rs9315812
O75570	375	408	407	407	Natural variant	ID=VAR_051789;Note=I->V;Dbxref=dbSNP:rs9315812

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	MTRF1	-3.09442355715565	0.0048209944049292
COAD	MTRF1	1.47985135182376	0.00729089975357057
BRCA	MTRF1	1.22201104478671	0.0180265605125636
CHOL	MTRF1	-4.61466528468525	0.02734375
KIRC	MTRF1	-4.93943424334119	9.90629858601199e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
PAAD	MTRF1	-0.27502185	0.015649788
ESCA	MTRF1	0.054080372	0.040450897
LIHC	MTRF1	0.044983581	0.044311725

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MTRF1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	TSG	MTRF1	CCAR1	0.814241691	4.05E-30
UCS	TSG	MTRF1	CCAR1	0.814241691	4.05E-30
UVM	Cell metabolism gene	MTRF1	IDI1	0.800056521	5.49E-19
UVM	Cell metabolism gene	MTRF1	AUH	0.800541464	5.05E-19
UVM	Cell metabolism gene	MTRF1	PHAX	0.80075158	4.87E-19
UVM	Cell metabolism gene	MTRF1	MTR	0.801520875	4.25E-19
UVM	Cell metabolism gene	MTRF1	ARFGEF2	0.801886272	3.99E-19
UVM	Cell metabolism gene	MTRF1	ACSL4	0.802949931	3.30E-19
UVM	Cell metabolism gene	MTRF1	PI4K2B	0.803017499	3.26E-19
UVM	Cell metabolism gene	MTRF1	AKAP5	0.803541643	2.97E-19
UVM	Cell metabolism gene	MTRF1	C1GALT1C1	0.803667589	2.91E-19
UVM	Cell metabolism gene	MTRF1	FBXW7	0.804562647	2.48E-19
UVM	Cell metabolism gene	MTRF1	COL4A3BP	0.805085387	2.25E-19
UVM	Cell metabolism gene	MTRF1	DBT	0.805514176	2.09E-19
UVM	Cell metabolism gene	MTRF1	SACM1L	0.806092239	1.88E-19
UVM	Cell metabolism gene	MTRF1	RPE	0.806742666	1.67E-19
UVM	Cell metabolism gene	MTRF1	NANP	0.806785756	1.66E-19
UVM	Cell metabolism gene	MTRF1	MINPP1	0.807586523	1.43E-19
UVM	Cell metabolism gene	MTRF1	PPAT	0.808303777	1.26E-19
UVM	Cell metabolism gene	MTRF1	DPM1	0.809744286	9.65E-20
UVM	Cell metabolism gene	MTRF1	ACADSB	0.810637779	8.18E-20
UVM	Cell metabolism gene	MTRF1	SGPP1	0.811714472	6.69E-20
UVM	Cell metabolism gene	MTRF1	IDI2	0.811785243	6.61E-20
UVM	Cell metabolism gene	MTRF1	TGS1	0.813426027	4.85E-20
UVM	Cell metabolism gene	MTRF1	GNPDA2	0.813791692	4.53E-20
UVM	Cell metabolism gene	MTRF1	MGAT2	0.814435876	4.01E-20
UVM	Cell metabolism gene	MTRF1	DCK	0.814686527	3.82E-20
UVM	Cell metabolism gene	MTRF1	AASS	0.81633122	2.79E-20
UVM	Cell metabolism gene	MTRF1	MANEA	0.817745144	2.13E-20
UVM	Cell metabolism gene	MTRF1	CNOT8	0.819439555	1.53E-20
UVM	Cell metabolism gene	MTRF1	PITPNB	0.820400429	1.27E-20
UVM	Cell metabolism gene	MTRF1	GPD2	0.821858902	9.48E-21
UVM	Cell metabolism gene	MTRF1	RANBP2	0.823157794	7.32E-21
UVM	Cell metabolism gene	MTRF1	CSGALNACT2	0.824175148	5.97E-21
UVM	Cell metabolism gene	MTRF1	NUDT12	0.825131962	4.92E-21
UVM	Cell metabolism gene	MTRF1	SRP19	0.825250787	4.80E-21
UVM	Cell metabolism gene	MTRF1	CDK8	0.825409851	4.65E-21
UVM	Cell metabolism gene	MTRF1	PNPLA8	0.828983108	2.23E-21
UVM	Cell metabolism gene	MTRF1	PSME4	0.830314802	1.69E-21
UVM	Cell metabolism gene	MTRF1	MCEE	0.83090793	1.49E-21
UVM	Cell metabolism gene	MTRF1	LCLAT1	0.835327994	5.80E-22
UVM	Cell metabolism gene	MTRF1	ALG13	0.835563383	5.51E-22
UVM	Cell metabolism gene	MTRF1	PIK3C2A	0.835921765	5.10E-22
UVM	Cell metabolism gene	MTRF1	FBXL3	0.837776318	3.40E-22
UVM	Cell metabolism gene	MTRF1	NUPL1	0.838624578	2.82E-22
UVM	Cell metabolism gene	MTRF1	TNPO1	0.842291213	1.24E-22
UVM	Cell metabolism gene	MTRF1	ALG10B	0.843196109	1.01E-22
UVM	Cell metabolism gene	MTRF1	GRPEL2	0.845422054	6.02E-23
UVM	Cell metabolism gene	MTRF1	PLA2G12A	0.847548771	3.66E-23
UVM	Cell metabolism gene	MTRF1	EDEM3	0.84877101	2.74E-23
UVM	Cell metabolism gene	MTRF1	MED17	0.850979906	1.61E-23
UVM	Cell metabolism gene	MTRF1	NAMPT	0.853005286	9.85E-24
UVM	Cell metabolism gene	MTRF1	PSMA4	0.854852444	6.24E-24
UVM	Cell metabolism gene	MTRF1	NUPL2	0.866738993	2.82E-25
UVM	Cell metabolism gene	MTRF1	PSMD14	0.866878488	2.72E-25
UVM	Cell metabolism gene	MTRF1	DIS3	0.877028581	1.51E-26
UVM	Cell metabolism gene	MTRF1	PRKAA1	0.877705848	1.23E-26
UVM	Cell metabolism gene	MTRF1	NUP107	0.878245646	1.05E-26
UVM	Cell metabolism gene	MTRF1	ETNK1	0.88047825	5.31E-27
UVM	Cell metabolism gene	MTRF1	MED7	0.88062659	5.07E-27
UVM	Cell metabolism gene	MTRF1	MED4	0.890441533	2.17E-28
UVM	Cell metabolism gene	MTRF1	MTMR6	0.894146542	6.09E-29
UVM	Cell metabolism gene	MTRF1	FAR1	0.895433117	3.87E-29
UVM	Cell metabolism gene	MTRF1	UGGT2	0.898172106	1.45E-29
UVM	Cell metabolism gene	MTRF1	PSMC6	0.898574989	1.25E-29
UVM	Cell metabolism gene	MTRF1	NUP50	0.900060669	7.25E-30
UVM	Cell metabolism gene	MTRF1	XPO1	0.911788902	7.00E-32
UVM	CGC	MTRF1	BCLAF1	0.800246005	5.32E-19
UVM	CGC	MTRF1	MDM4	0.802008713	3.90E-19
UVM	CGC	MTRF1	FIP1L1	0.8025913	3.52E-19
UVM	CGC	MTRF1	RB1	0.804496207	2.51E-19
UVM	CGC	MTRF1	FBXW7	0.804562647	2.48E-19
UVM	CGC	MTRF1	ABI1	0.80495427	2.31E-19
UVM	CGC	MTRF1	NBN	0.806248895	1.83E-19
UVM	CGC	MTRF1	TRIM24	0.806388553	1.78E-19
UVM	CGC	MTRF1	AKAP9	0.806905112	1.62E-19
UVM	CGC	MTRF1	ARID2	0.808481305	1.22E-19
UVM	CGC	MTRF1	TOP1	0.809895739	9.39E-20
UVM	CGC	MTRF1	ATRX	0.811050296	7.58E-20
UVM	CGC	MTRF1	JAK2	0.811155402	7.43E-20
UVM	CGC	MTRF1	TET2	0.813592365	4.70E-20
UVM	CGC	MTRF1	RANBP2	0.823157794	7.32E-21
UVM	CGC	MTRF1	RABEP1	0.824009149	6.17E-21
UVM	CGC	MTRF1	GOLGA5	0.827753911	2.88E-21
UVM	CGC	MTRF1	DICER1	0.830140424	1.75E-21
UVM	CGC	MTRF1	BRCA2	0.833233518	9.10E-22
UVM	CGC	MTRF1	KRAS	0.836239386	4.76E-22
UVM	CGC	MTRF1	POT1	0.837847485	3.34E-22
UVM	CGC	MTRF1	CDC73	0.839016957	2.58E-22
UVM	CGC	MTRF1	BMPR1A	0.839992451	2.08E-22
UVM	CGC	MTRF1	SS18L1	0.841328202	1.54E-22
UVM	CGC	MTRF1	CUL3	0.841432249	1.50E-22
UVM	CGC	MTRF1	STAG2	0.842366737	1.22E-22
UVM	CGC	MTRF1	USP8	0.843632312	9.10E-23
UVM	CGC	MTRF1	FBXO11	0.856161806	4.50E-24
UVM	CGC	MTRF1	CREB1	0.860126771	1.64E-24
UVM	CGC	MTRF1	RAD17	0.860238329	1.59E-24
UVM	CGC	MTRF1	KTN1	0.861303779	1.20E-24
UVM	CGC	MTRF1	EZH2	0.861790892	1.06E-24
UVM	CGC	MTRF1	KIF5B	0.86888318	1.56E-25
UVM	CGC	MTRF1	SUZ12	0.876086045	1.99E-26
UVM	CGC	MTRF1	DDX5	0.877080344	1.48E-26
UVM	CGC	MTRF1	ETNK1	0.88047825	5.31E-27
UVM	CGC	MTRF1	SF3B1	0.888748635	3.81E-28
UVM	CGC	MTRF1	ZMYM2	0.890260965	2.30E-28
UVM	CGC	MTRF1	PWWP2A	0.892799934	9.71E-29
UVM	CGC	MTRF1	BAZ1A	0.910609286	1.15E-31
UVM	CGC	MTRF1	XPO1	0.911788902	7.00E-32
UVM	CGC	MTRF1	ATM	0.91695356	7.35E-33
UVM	CGC	MTRF1	PMS1	0.929694857	1.42E-35
UVM	Epifactor	MTRF1	RCOR3	0.80034778	5.22E-19
UVM	Epifactor	MTRF1	HCFC2	0.800454838	5.12E-19
UVM	Epifactor	MTRF1	PHIP	0.80085326	4.78E-19
UVM	Epifactor	MTRF1	TLK2	0.802004401	3.90E-19
UVM	Epifactor	MTRF1	MBTD1	0.802784196	3.40E-19
UVM	Epifactor	MTRF1	RB1	0.804496207	2.51E-19
UVM	Epifactor	MTRF1	CTBP2	0.805600245	2.06E-19
UVM	Epifactor	MTRF1	H2AFV	0.806160014	1.86E-19
UVM	Epifactor	MTRF1	NBN	0.806248895	1.83E-19
UVM	Epifactor	MTRF1	BRMS1L	0.806288571	1.82E-19
UVM	Epifactor	MTRF1	TRIM24	0.806388553	1.78E-19
UVM	Epifactor	MTRF1	ARID2	0.808481305	1.22E-19
UVM	Epifactor	MTRF1	ATRX	0.811050296	7.58E-20
UVM	Epifactor	MTRF1	JAK2	0.811155402	7.43E-20
UVM	Epifactor	MTRF1	TET2	0.813592365	4.70E-20
UVM	Epifactor	MTRF1	LEO1	0.814356456	4.07E-20
UVM	Epifactor	MTRF1	ANP32E	0.814750449	3.78E-20
UVM	Epifactor	MTRF1	ARID4B	0.815550302	3.24E-20
UVM	Epifactor	MTRF1	CUL1	0.819304259	1.57E-20
UVM	Epifactor	MTRF1	HAT1	0.819582593	1.49E-20
UVM	Epifactor	MTRF1	RMI1	0.819904008	1.40E-20
UVM	Epifactor	MTRF1	UHRF2	0.82102286	1.12E-20
UVM	Epifactor	MTRF1	PHF14	0.824928687	5.12E-21
UVM	Epifactor	MTRF1	TAF2	0.826837954	3.47E-21
UVM	Epifactor	MTRF1	BRCC3	0.828180413	2.63E-21
UVM	Epifactor	MTRF1	FAM175B	0.829160496	2.15E-21
UVM	Epifactor	MTRF1	CHD9	0.829938679	1.83E-21
UVM	Epifactor	MTRF1	GATAD1	0.830077127	1.77E-21
UVM	Epifactor	MTRF1	CHD1	0.830223506	1.72E-21
UVM	Epifactor	MTRF1	ACTR6	0.830469308	1.63E-21
UVM	Epifactor	MTRF1	CDK17	0.831706767	1.26E-21
UVM	Epifactor	MTRF1	PCGF6	0.832651531	1.03E-21
UVM	Epifactor	MTRF1	YEATS4	0.832758979	1.01E-21
UVM	Epifactor	MTRF1	BRCA2	0.833233518	9.10E-22
UVM	Epifactor	MTRF1	DNAJC2	0.833395545	8.79E-22
UVM	Epifactor	MTRF1	UCHL5	0.834711511	6.63E-22
UVM	Epifactor	MTRF1	CDC73	0.839016957	2.58E-22
UVM	Epifactor	MTRF1	DNTTIP2	0.840938379	1.68E-22
UVM	Epifactor	MTRF1	SMARCAD1	0.841258105	1.56E-22
UVM	Epifactor	MTRF1	SS18L1	0.841328202	1.54E-22
UVM	Epifactor	MTRF1	CUL3	0.841432249	1.50E-22
UVM	Epifactor	MTRF1	NIPBL	0.8452363	6.29E-23
UVM	Epifactor	MTRF1	NSL1	0.846531059	4.65E-23
UVM	Epifactor	MTRF1	RLIM	0.848252663	3.10E-23
UVM	Epifactor	MTRF1	CBX3	0.85012103	1.98E-23
UVM	Epifactor	MTRF1	EPC2	0.851076579	1.58E-23
UVM	Epifactor	MTRF1	CIR1	0.853338739	9.08E-24
UVM	Epifactor	MTRF1	SMARCA5	0.854061232	7.59E-24
UVM	Epifactor	MTRF1	EID1	0.854771903	6.37E-24
UVM	Epifactor	MTRF1	SP100	0.855440439	5.39E-24
UVM	Epifactor	MTRF1	BAZ2B	0.859703851	1.83E-24
UVM	Epifactor	MTRF1	EZH2	0.861790892	1.06E-24
UVM	Epifactor	MTRF1	PHF20L1	0.862206392	9.51E-25
UVM	Epifactor	MTRF1	MASTL	0.863841952	6.16E-25
UVM	Epifactor	MTRF1	AEBP2	0.86437299	5.35E-25
UVM	Epifactor	MTRF1	CUL5	0.866736849	2.82E-25
UVM	Epifactor	MTRF1	TLK1	0.870819759	9.09E-26
UVM	Epifactor	MTRF1	TDG	0.872370749	5.85E-26
UVM	Epifactor	MTRF1	ARID4A	0.874896234	2.82E-26
UVM	Epifactor	MTRF1	BRWD1	0.875601315	2.30E-26
UVM	Epifactor	MTRF1	SUZ12	0.876086045	1.99E-26
UVM	Epifactor	MTRF1	PRKAA1	0.877705848	1.23E-26
UVM	Epifactor	MTRF1	INO80D	0.879126782	8.02E-27
UVM	Epifactor	MTRF1	ATAD2B	0.879839814	6.46E-27
UVM	Epifactor	MTRF1	OGT	0.882014005	3.30E-27
UVM	Epifactor	MTRF1	JMJD1C	0.882385136	2.94E-27
UVM	Epifactor	MTRF1	SMEK2	0.884480897	1.52E-27
UVM	Epifactor	MTRF1	TAF7	0.8855139	1.09E-27
UVM	Epifactor	MTRF1	CUL2	0.886189379	8.80E-28
UVM	Epifactor	MTRF1	SF3B1	0.888748635	3.81E-28
UVM	Epifactor	MTRF1	ZMYM2	0.890260965	2.30E-28
UVM	Epifactor	MTRF1	SMEK1	0.891621141	1.45E-28
UVM	Epifactor	MTRF1	USP15	0.905185262	1.03E-30
UVM	Epifactor	MTRF1	BAZ1A	0.910609286	1.15E-31
UVM	Epifactor	MTRF1	HMGB1	0.910843578	1.04E-31
UVM	Epifactor	MTRF1	ATM	0.91695356	7.35E-33
UVM	IUPHAR	MTRF1	IDI1	0.800056521	5.49E-19
UVM	IUPHAR	MTRF1	PHIP	0.80085326	4.78E-19
UVM	IUPHAR	MTRF1	SLC26A2	0.800955095	4.69E-19
UVM	IUPHAR	MTRF1	NIPA1	0.801037173	4.63E-19
UVM	IUPHAR	MTRF1	MTR	0.801520875	4.25E-19
UVM	IUPHAR	MTRF1	TLK2	0.802004401	3.90E-19
UVM	IUPHAR	MTRF1	NEK3	0.802537408	3.55E-19
UVM	IUPHAR	MTRF1	DYRK1A	0.80254775	3.55E-19
UVM	IUPHAR	MTRF1	CDK13	0.80284813	3.36E-19
UVM	IUPHAR	MTRF1	PI4K2B	0.803017499	3.26E-19
UVM	IUPHAR	MTRF1	ATP11C	0.805533904	2.08E-19
UVM	IUPHAR	MTRF1	TRIM24	0.806388553	1.78E-19
UVM	IUPHAR	MTRF1	PLK4	0.806895449	1.63E-19
UVM	IUPHAR	MTRF1	PPAT	0.808303777	1.26E-19
UVM	IUPHAR	MTRF1	USP14	0.808653078	1.18E-19
UVM	IUPHAR	MTRF1	ADAM17	0.808767951	1.16E-19
UVM	IUPHAR	MTRF1	NEK7	0.808827006	1.14E-19
UVM	IUPHAR	MTRF1	TMEM165	0.809459558	1.02E-19
UVM	IUPHAR	MTRF1	TOP1	0.809895739	9.39E-20
UVM	IUPHAR	MTRF1	JAK2	0.811155402	7.43E-20
UVM	IUPHAR	MTRF1	SGPP1	0.811714472	6.69E-20
UVM	IUPHAR	MTRF1	IDI2	0.811785243	6.61E-20
UVM	IUPHAR	MTRF1	PRPF4B	0.812892535	5.37E-20
UVM	IUPHAR	MTRF1	SLC37A3	0.813524116	4.77E-20
UVM	IUPHAR	MTRF1	SLC25A46	0.816112146	2.91E-20
UVM	IUPHAR	MTRF1	IFNGR1	0.816519111	2.69E-20
UVM	IUPHAR	MTRF1	BMPR2	0.817007208	2.45E-20
UVM	IUPHAR	MTRF1	HAT1	0.819582593	1.49E-20
UVM	IUPHAR	MTRF1	ABCB10	0.824812152	5.25E-21
UVM	IUPHAR	MTRF1	PKN2	0.825123765	4.92E-21
UVM	IUPHAR	MTRF1	CDK8	0.825409851	4.65E-21
UVM	IUPHAR	MTRF1	VRK2	0.83102801	1.45E-21
UVM	IUPHAR	MTRF1	MAP3K2	0.831237934	1.39E-21
UVM	IUPHAR	MTRF1	CDK17	0.831706767	1.26E-21
UVM	IUPHAR	MTRF1	PIK3C2A	0.835921765	5.10E-22
UVM	IUPHAR	MTRF1	KRAS	0.836239386	4.76E-22
UVM	IUPHAR	MTRF1	MAPK6	0.836706726	4.29E-22
UVM	IUPHAR	MTRF1	CYP2R1	0.837957783	3.26E-22
UVM	IUPHAR	MTRF1	BMPR1A	0.839992451	2.08E-22
UVM	IUPHAR	MTRF1	BIRC2	0.84035346	1.92E-22
UVM	IUPHAR	MTRF1	PRMT3	0.842668128	1.13E-22
UVM	IUPHAR	MTRF1	ATP6V0A2	0.842968684	1.06E-22
UVM	IUPHAR	MTRF1	TRPM7	0.845732175	5.60E-23
UVM	IUPHAR	MTRF1	RIOK3	0.846984451	4.18E-23
UVM	IUPHAR	MTRF1	PLA2G12A	0.847548771	3.66E-23
UVM	IUPHAR	MTRF1	CLK1	0.848201482	3.14E-23
UVM	IUPHAR	MTRF1	CLK4	0.851393524	1.46E-23
UVM	IUPHAR	MTRF1	TNKS2	0.854691633	6.50E-24
UVM	IUPHAR	MTRF1	SP100	0.855440439	5.39E-24
UVM	IUPHAR	MTRF1	FBXO11	0.856161806	4.50E-24
UVM	IUPHAR	MTRF1	BAZ2B	0.859703851	1.83E-24
UVM	IUPHAR	MTRF1	IRAK4	0.860482028	1.49E-24
UVM	IUPHAR	MTRF1	EZH2	0.861790892	1.06E-24
UVM	IUPHAR	MTRF1	NR2C1	0.86298862	7.73E-25
UVM	IUPHAR	MTRF1	MAP4K3	0.863663936	6.46E-25
UVM	IUPHAR	MTRF1	MASTL	0.863841952	6.16E-25
UVM	IUPHAR	MTRF1	CSNK1G3	0.866501132	3.01E-25
UVM	IUPHAR	MTRF1	PSMD14	0.866878488	2.72E-25
UVM	IUPHAR	MTRF1	STK17A	0.870086041	1.12E-25
UVM	IUPHAR	MTRF1	TLK1	0.870819759	9.09E-26
UVM	IUPHAR	MTRF1	CSNK1A1	0.871556368	7.38E-26
UVM	IUPHAR	MTRF1	NAPEPLD	0.874653859	3.03E-26
UVM	IUPHAR	MTRF1	BRWD1	0.875601315	2.30E-26
UVM	IUPHAR	MTRF1	XIAP	0.87725082	1.41E-26
UVM	IUPHAR	MTRF1	PRKAA1	0.877705848	1.23E-26
UVM	IUPHAR	MTRF1	ATAD2B	0.879839814	6.46E-27
UVM	IUPHAR	MTRF1	TBK1	0.881960735	3.36E-27
UVM	IUPHAR	MTRF1	JMJD1C	0.882385136	2.94E-27
UVM	IUPHAR	MTRF1	MARK3	0.900277396	6.69E-30
UVM	IUPHAR	MTRF1	BAZ1A	0.910609286	1.15E-31
UVM	IUPHAR	MTRF1	XPO1	0.911788902	7.00E-32
UVM	IUPHAR	MTRF1	ATM	0.91695356	7.35E-33
UVM	Kinase	MTRF1	TLK2	0.802004401	3.90E-19
UVM	Kinase	MTRF1	NEK3	0.802537408	3.55E-19
UVM	Kinase	MTRF1	DYRK1A	0.80254775	3.55E-19
UVM	Kinase	MTRF1	CDK13	0.80284813	3.36E-19
UVM	Kinase	MTRF1	COL4A3BP	0.805085387	2.25E-19
UVM	Kinase	MTRF1	TRIM24	0.806388553	1.78E-19
UVM	Kinase	MTRF1	PLK4	0.806895449	1.63E-19
UVM	Kinase	MTRF1	NEK7	0.808827006	1.14E-19
UVM	Kinase	MTRF1	JAK2	0.811155402	7.43E-20
UVM	Kinase	MTRF1	PRPF4B	0.812892535	5.37E-20
UVM	Kinase	MTRF1	BMPR2	0.817007208	2.45E-20
UVM	Kinase	MTRF1	PKN2	0.825123765	4.92E-21
UVM	Kinase	MTRF1	CDK8	0.825409851	4.65E-21
UVM	Kinase	MTRF1	VRK2	0.83102801	1.45E-21
UVM	Kinase	MTRF1	MAP3K2	0.831237934	1.39E-21
UVM	Kinase	MTRF1	CDK17	0.831706767	1.26E-21
UVM	Kinase	MTRF1	PAN3	0.832926932	9.72E-22
UVM	Kinase	MTRF1	MAPK6	0.836706726	4.29E-22
UVM	Kinase	MTRF1	BMPR1A	0.839992451	2.08E-22
UVM	Kinase	MTRF1	TRPM7	0.845732175	5.60E-23
UVM	Kinase	MTRF1	RIOK3	0.846984451	4.18E-23
UVM	Kinase	MTRF1	CLK1	0.848201482	3.14E-23
UVM	Kinase	MTRF1	CLK4	0.851393524	1.46E-23
UVM	Kinase	MTRF1	IRAK4	0.860482028	1.49E-24
UVM	Kinase	MTRF1	MAP4K3	0.863663936	6.46E-25
UVM	Kinase	MTRF1	MASTL	0.863841952	6.16E-25
UVM	Kinase	MTRF1	CSNK1G3	0.866501132	3.01E-25
UVM	Kinase	MTRF1	STK17A	0.870086041	1.12E-25
UVM	Kinase	MTRF1	TLK1	0.870819759	9.09E-26
UVM	Kinase	MTRF1	CSNK1A1	0.871556368	7.38E-26
UVM	Kinase	MTRF1	PRKAA1	0.877705848	1.23E-26
UVM	Kinase	MTRF1	TBK1	0.881960735	3.36E-27
UVM	Kinase	MTRF1	MARK3	0.900277396	6.69E-30
UVM	Kinase	MTRF1	BAZ1A	0.910609286	1.15E-31
UVM	Kinase	MTRF1	ATM	0.91695356	7.35E-33
UVM	TF	MTRF1	ZNF45	0.800582759	5.01E-19
UVM	TF	MTRF1	ZNF23	0.801103312	4.57E-19
UVM	TF	MTRF1	GABPA	0.801239659	4.47E-19
UVM	TF	MTRF1	ZBTB25	0.803074605	3.23E-19
UVM	TF	MTRF1	ZNF225	0.803601364	2.94E-19
UVM	TF	MTRF1	ZNF600	0.804101795	2.69E-19
UVM	TF	MTRF1	ZNF347	0.804179158	2.65E-19
UVM	TF	MTRF1	ZNF37A	0.804194243	2.65E-19
UVM	TF	MTRF1	ZNF107	0.805472406	2.10E-19
UVM	TF	MTRF1	ZNF585B	0.806023911	1.90E-19
UVM	TF	MTRF1	ZNF14	0.807125964	1.56E-19
UVM	TF	MTRF1	ARID2	0.808481305	1.22E-19
UVM	TF	MTRF1	ZNF146	0.809012246	1.10E-19
UVM	TF	MTRF1	ZNF567	0.80963709	9.84E-20
UVM	TF	MTRF1	ZNF440	0.81346134	4.82E-20
UVM	TF	MTRF1	TET2	0.813592365	4.70E-20
UVM	TF	MTRF1	ZMAT1	0.813735166	4.58E-20
UVM	TF	MTRF1	ZNF555	0.814209278	4.19E-20
UVM	TF	MTRF1	ZNF761	0.815449106	3.31E-20
UVM	TF	MTRF1	ZNF799	0.815913593	3.03E-20
UVM	TF	MTRF1	ZNF254	0.816069879	2.94E-20
UVM	TF	MTRF1	ZNF200	0.816111741	2.91E-20
UVM	TF	MTRF1	TERF1	0.816365592	2.77E-20
UVM	TF	MTRF1	ZNF564	0.816387177	2.76E-20
UVM	TF	MTRF1	CEBPG	0.817018599	2.45E-20
UVM	TF	MTRF1	ZBTB41	0.817216204	2.35E-20
UVM	TF	MTRF1	ZNF326	0.817564761	2.20E-20
UVM	TF	MTRF1	ZNF131	0.81801486	2.02E-20
UVM	TF	MTRF1	BACH1	0.819938833	1.39E-20
UVM	TF	MTRF1	ZNF823	0.820582142	1.22E-20
UVM	TF	MTRF1	ZNF721	0.820966662	1.13E-20
UVM	TF	MTRF1	ZNF24	0.82148719	1.02E-20
UVM	TF	MTRF1	ZNF224	0.822251434	8.77E-21
UVM	TF	MTRF1	ZNF557	0.822924571	7.67E-21
UVM	TF	MTRF1	SP3	0.823070403	7.45E-21
UVM	TF	MTRF1	ELF2	0.823175176	7.29E-21
UVM	TF	MTRF1	ZNF432	0.823431958	6.93E-21
UVM	TF	MTRF1	ZNF566	0.824002558	6.18E-21
UVM	TF	MTRF1	ZNF230	0.82443501	5.66E-21
UVM	TF	MTRF1	ZNF268	0.8246087	5.47E-21
UVM	TF	MTRF1	ZNF565	0.824733688	5.33E-21
UVM	TF	MTRF1	ZNF845	0.825041509	5.01E-21
UVM	TF	MTRF1	JRKL	0.825910846	4.20E-21
UVM	TF	MTRF1	ZNF83	0.826085398	4.05E-21
UVM	TF	MTRF1	ZNF674	0.826482501	3.73E-21
UVM	TF	MTRF1	MEF2A	0.827112122	3.28E-21
UVM	TF	MTRF1	ZNF354B	0.828177815	2.63E-21
UVM	TF	MTRF1	MYBL1	0.82852477	2.45E-21
UVM	TF	MTRF1	TOPORS	0.829346536	2.07E-21
UVM	TF	MTRF1	LIN54	0.829908871	1.84E-21
UVM	TF	MTRF1	ZNF680	0.83170548	1.26E-21
UVM	TF	MTRF1	PCGF6	0.832651531	1.03E-21
UVM	TF	MTRF1	FOXN2	0.833057334	9.45E-22
UVM	TF	MTRF1	AHCTF1	0.833432227	8.72E-22
UVM	TF	MTRF1	ZNF780B	0.834964842	6.27E-22
UVM	TF	MTRF1	ZNF260	0.835392771	5.72E-22
UVM	TF	MTRF1	ZNF141	0.835526688	5.55E-22
UVM	TF	MTRF1	ZNF266	0.837315621	3.76E-22
UVM	TF	MTRF1	ZNF138	0.837480799	3.62E-22
UVM	TF	MTRF1	ZNF44	0.838023113	3.22E-22
UVM	TF	MTRF1	ELF1	0.838319947	3.01E-22
UVM	TF	MTRF1	ZBTB6	0.838534927	2.87E-22
UVM	TF	MTRF1	ZNF248	0.839309981	2.42E-22
UVM	TF	MTRF1	ZNF180	0.841143441	1.60E-22
UVM	TF	MTRF1	ZNF430	0.842563206	1.16E-22
UVM	TF	MTRF1	PRMT3	0.842668128	1.13E-22
UVM	TF	MTRF1	ZNF280D	0.843223167	1.00E-22
UVM	TF	MTRF1	ZNF624	0.84506754	6.54E-23
UVM	TF	MTRF1	ZNF302	0.846405059	4.79E-23
UVM	TF	MTRF1	ZNF28	0.846416598	4.78E-23
UVM	TF	MTRF1	ZNF12	0.846930229	4.23E-23
UVM	TF	MTRF1	ZNF484	0.846998139	4.17E-23
UVM	TF	MTRF1	ZNF800	0.84735535	3.83E-23
UVM	TF	MTRF1	ZNF10	0.848653497	2.82E-23
UVM	TF	MTRF1	ZBED5	0.84866933	2.81E-23
UVM	TF	MTRF1	ZNF222	0.849749407	2.17E-23
UVM	TF	MTRF1	THAP9	0.84995706	2.06E-23
UVM	TF	MTRF1	ZNF92	0.850393339	1.86E-23
UVM	TF	MTRF1	THAP6	0.853474848	8.78E-24
UVM	TF	MTRF1	ZNF708	0.855019953	5.99E-24
UVM	TF	MTRF1	SP100	0.855440439	5.39E-24
UVM	TF	MTRF1	ZNF701	0.856875248	3.76E-24
UVM	TF	MTRF1	SMAD5	0.857160708	3.50E-24
UVM	TF	MTRF1	ZNF383	0.857439401	3.26E-24
UVM	TF	MTRF1	ZNF431	0.858133854	2.73E-24
UVM	TF	MTRF1	ZNF658	0.858542567	2.46E-24
UVM	TF	MTRF1	ZNF100	0.859658765	1.85E-24
UVM	TF	MTRF1	BAZ2B	0.859703851	1.83E-24
UVM	TF	MTRF1	ZNF480	0.85989342	1.74E-24
UVM	TF	MTRF1	CREB1	0.860126771	1.64E-24
UVM	TF	MTRF1	ZNF84	0.860326621	1.55E-24
UVM	TF	MTRF1	ZNF546	0.860632969	1.43E-24
UVM	TF	MTRF1	PRDM10	0.861293834	1.21E-24
UVM	TF	MTRF1	RBAK	0.862424823	8.98E-25
UVM	TF	MTRF1	NR2C1	0.86298862	7.73E-25
UVM	TF	MTRF1	AEBP2	0.86437299	5.35E-25
UVM	TF	MTRF1	ZNF267	0.86438439	5.33E-25
UVM	TF	MTRF1	ZNF234	0.865499033	3.95E-25
UVM	TF	MTRF1	PURB	0.866929626	2.68E-25
UVM	TF	MTRF1	ZNF101	0.86776856	2.13E-25
UVM	TF	MTRF1	ZNF136	0.869117002	1.47E-25
UVM	TF	MTRF1	ZNF25	0.86914789	1.45E-25
UVM	TF	MTRF1	THAP5	0.871174358	8.23E-26
UVM	TF	MTRF1	IKZF5	0.872488998	5.66E-26
UVM	TF	MTRF1	ZNF33A	0.873143692	4.69E-26
UVM	TF	MTRF1	ZNF510	0.876439565	1.79E-26
UVM	TF	MTRF1	ZNF527	0.876988639	1.52E-26
UVM	TF	MTRF1	GPBP1	0.878410275	9.95E-27
UVM	TF	MTRF1	ZNF75D	0.879551406	7.05E-27
UVM	TF	MTRF1	CEBPZ	0.879631995	6.88E-27
UVM	TF	MTRF1	ZNF518A	0.886655057	7.57E-28
UVM	TF	MTRF1	ZNF780A	0.890252291	2.31E-28
UVM	TF	MTRF1	ZNF451	0.891471255	1.53E-28
UVM	TF	MTRF1	ZNF26	0.891873255	1.33E-28
UVM	TF	MTRF1	ZNF449	0.8928472	9.55E-29
UVM	TF	MTRF1	ZNF182	0.892871971	9.47E-29
UVM	TF	MTRF1	ZNF140	0.892960501	9.18E-29
UVM	TF	MTRF1	ZNF195	0.893269196	8.26E-29
UVM	TF	MTRF1	ZNF226	0.894856397	4.75E-29
UVM	TF	MTRF1	ZNF181	0.896626143	2.53E-29
UVM	TF	MTRF1	ZBTB1	0.897395082	1.92E-29
UVM	TF	MTRF1	ZNF43	0.89916417	1.01E-29
UVM	TF	MTRF1	DMTF1	0.901906684	3.63E-30
UVM	TF	MTRF1	CREBZF	0.905174964	1.03E-30
UVM	TF	MTRF1	ZNF700	0.908339557	2.92E-31
UVM	TF	MTRF1	ZNF441	0.910716304	1.10E-31
UVM	TF	MTRF1	ZNF675	0.916789079	7.92E-33
UVM	TSG	MTRF1	RB1	0.804496207	2.51E-19
UVM	TSG	MTRF1	FBXW7	0.804562647	2.48E-19
UVM	TSG	MTRF1	NBN	0.806248895	1.83E-19
UVM	TSG	MTRF1	TRIM24	0.806388553	1.78E-19
UVM	TSG	MTRF1	ARID2	0.808481305	1.22E-19
UVM	TSG	MTRF1	LIN9	0.808710811	1.17E-19
UVM	TSG	MTRF1	PTPN12	0.809288632	1.05E-19
UVM	TSG	MTRF1	TET2	0.813592365	4.70E-20
UVM	TSG	MTRF1	VEZT	0.814039729	4.32E-20
UVM	TSG	MTRF1	GTPBP4	0.816558439	2.67E-20
UVM	TSG	MTRF1	BMPR2	0.817007208	2.45E-20
UVM	TSG	MTRF1	CUL1	0.819304259	1.57E-20
UVM	TSG	MTRF1	UHRF2	0.82102286	1.12E-20
UVM	TSG	MTRF1	PPP2R5C	0.82293802	7.65E-21
UVM	TSG	MTRF1	TANK	0.823689681	6.58E-21
UVM	TSG	MTRF1	ANXA7	0.823805892	6.43E-21
UVM	TSG	MTRF1	PPM1A	0.825173442	4.88E-21
UVM	TSG	MTRF1	RB1CC1	0.826061585	4.07E-21
UVM	TSG	MTRF1	TOPORS	0.829346536	2.07E-21
UVM	TSG	MTRF1	DICER1	0.830140424	1.75E-21
UVM	TSG	MTRF1	CHD1	0.830223506	1.72E-21
UVM	TSG	MTRF1	BRCA2	0.833233518	9.10E-22
UVM	TSG	MTRF1	TBRG1	0.837831357	3.36E-22
UVM	TSG	MTRF1	CDC73	0.839016957	2.58E-22
UVM	TSG	MTRF1	BMPR1A	0.839992451	2.08E-22
UVM	TSG	MTRF1	CCAR1	0.844198333	7.99E-23
UVM	TSG	MTRF1	RBBP8	0.84675677	4.41E-23
UVM	TSG	MTRF1	WDR11	0.849039898	2.57E-23
UVM	TSG	MTRF1	NEDD4	0.850766682	1.70E-23
UVM	TSG	MTRF1	IFT88	0.854600185	6.65E-24
UVM	TSG	MTRF1	DCLRE1A	0.854870515	6.21E-24
UVM	TSG	MTRF1	SP100	0.855440439	5.39E-24
UVM	TSG	MTRF1	GGNBP2	0.857129481	3.52E-24
UVM	TSG	MTRF1	PDS5B	0.857409462	3.28E-24
UVM	TSG	MTRF1	EZH2	0.861790892	1.06E-24
UVM	TSG	MTRF1	CUL5	0.866736849	2.82E-25
UVM	TSG	MTRF1	SMCHD1	0.869404669	1.35E-25
UVM	TSG	MTRF1	FAM188A	0.871402428	7.71E-26
UVM	TSG	MTRF1	CSNK1A1	0.871556368	7.38E-26
UVM	TSG	MTRF1	NAPEPLD	0.874653859	3.03E-26
UVM	TSG	MTRF1	SUZ12	0.876086045	1.99E-26
UVM	TSG	MTRF1	PRKAA1	0.877705848	1.23E-26
UVM	TSG	MTRF1	APAF1	0.884435204	1.54E-27
UVM	TSG	MTRF1	KRIT1	0.88476122	1.39E-27
UVM	TSG	MTRF1	CUL2	0.886189379	8.80E-28
UVM	TSG	MTRF1	MLH3	0.888242642	4.50E-28
UVM	TSG	MTRF1	INTS6	0.891221897	1.66E-28
UVM	TSG	MTRF1	RINT1	0.89925382	9.77E-30
UVM	TSG	MTRF1	DMTF1	0.901906684	3.63E-30
UVM	TSG	MTRF1	GORAB	0.913218452	3.80E-32
UVM	TSG	MTRF1	ATM	0.91695356	7.35E-33

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MTRF1	MTIF2	-1.91099017365555	0.000110303983092308
KIRC	MTRF1	MRPL20	1.48585631024503	0.000111704804180407
KICH	MTRF1	MRPL9	1.16888038960038	0.000120222568511963
PRAD	MTRF1	MTIF2	-2.91163945232732	0.000148819683073472
THCA	MTRF1	GFM2	1.24335152208863	0.000405886158765646
LUAD	MTRF1	MRPL20	-3.00071204707904	0.000452706327224566
THCA	MTRF1	MTIF2	1.01909960064239	0.00052377205169468
LIHC	MTRF1	MRPL13	1.54402472107614	0.000655351190157038
BRCA	MTRF1	MRPL20	-1.74379528461375	0.000756034430433012
KICH	MTRF1	MRRF	1.86992130954506	0.0014527440071106
KIRP	MTRF1	GFM1	-3.60557651795202	0.00154796987771988
KICH	MTRF1	GFM1	1.05246565332639	0.00378090143203735
KIRP	MTRF1	GFM2	-3.00163848603689	0.0044123362749815
ESCA	MTRF1	MRPL13	-1.07746088474995	0.0068359375
PRAD	MTRF1	ICT1	-1.54848444909352	0.00907723161841939
LUSC	MTRF1	GFM2	-1.44135486663635	0.00981186007251347
STAD	MTRF1	MRPL9	-1.54523483458273	0.0118026207201183
LIHC	MTRF1	MRPL20	-1.08735154161025	0.0158079482509981
KIRC	MTRF1	MTIF2	-1.30575511475086	0.0182888755834972
THCA	MTRF1	MRPS11	-3.10694728540962	0.0252226935182201
LIHC	MTRF1	MRRF	-1.19805818879659	0.0305924082275009
BLCA	MTRF1	MRPS11	-2.30276998968219	0.040130615234375
BRCA	MTRF1	MRPS11	-1.24304977976804	2.31302509538916e-07
BRCA	MTRF1	ICT1	-4.17488220449664	2.73719348917167e-14
PRAD	MTRF1	MRRF	-1.56810957454655	2.74398347191128e-05
KIRC	MTRF1	GFM2	-2.05005965144326	3.97470828213212e-07
LUAD	MTRF1	MTIF2	-5.14356588709714	3.996080695583e-11
LUAD	MTRF1	GFM1	-2.84901818322678	4.2869535120076e-07
LUSC	MTRF1	MRPS11	-2.9004097541444	5.43966600483641e-07
LUSC	MTRF1	ICT1	-3.23093376049456	6.60526357089358e-07
BRCA	MTRF1	GFM1	1.76831243345242	7.05963288731276e-10
LUAD	MTRF1	GFM2	-3.28752735953651	9.23397908905824e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MTRF1

PARK7, MOV10, CSK, KRT8, E, ORF6, C21orf33, AARS2, ABCB7, ACAD9, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALAS1, ANGEL2, ATP5B, ATP5J2-PTCD1, ATP5F1, ATP5J, ATPAF1, BCKDHA, BCS1L, C17orf80, C7orf55-LUC7L2, CARS2, CENPV, CLPP, CLPX, COQ5, COX5A, CS, DAP3, DBT, DHX30, DLAT, DLST, DNAJC28, ECHS1, ECSIT, EIF2AK2, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FASTKD5, GADD45GIP1, GATB, GCDH, GFM1, GLS, GLUD1, GRSF1, GTPBP10, GTPBP6, GUF1, HADHA, HARS2, HINT2, HNRNPAB, HNRNPDL, HNRNPL, HNRNPUL1, HSDL2, HSPE1, IARS2, KIAA0391, LARS2, LETM1, LRP2, LRPPRC, LYRM2, LYRM4, MDH2, ME2, MMAB, RNMTL1, MRPL1, MRPL10, MRPL12, MRPL13, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL35, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL53, MRPL55, ICT1, MRPL9, MRPS10, MRPS11, MRPS14, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTERF3, MTIF2, MTPAP, MTRF1L, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF4, NDUFAF5, NDUFAF7, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NNT, NOA1, OGDH, PAM16, PDE12, PDHA1, PDHB, PDHX, PDK3, PDPR, PMPCA, PNPT1, POLDIP2, POLG, POLRMT, PPA2, PPIF, PREPL, PTCD3, PYCR1, PYCR2, QRSL1, RBMX, RPS27A, RTN4IP1, ACN9, SHMT2, SLC30A9, SLIRP, STOML2, SUCLA2, SUPV3L1, TACO1, TEFM, TFAM, THEM4, THG1L, TIMM44, TOP3A, TRMT10C, TRMT11, TRMT5, TRMT61B, TRUB2, C10orf2, VARS2, VWA8, TSFM, SREBF2, TP53, C4orf29, ASB7, ATF7IP, LYPLA1, CADM4, PALM, C1orf21, MTMR2, VAMP3, XRCC4, PBX2, RHOB, TYW3, C7orf55, PALB2, BLK, MEIS1, ACTA1, YES1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MTRF1	chr13	41791310	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MTRF1	chr13	41814538	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MTRF1	chr13	41827092	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
MTRF1	chr13	41834639	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MTRF1	READ	chr13	41826864	41826864	C	T	Missense_Mutation	p.R205Q	4
MTRF1	SKCM	chr13	41814411	41814411	G	A	Missense_Mutation	p.P286S	4
MTRF1	PAAD	chr13	41791362	41791362	T	A	Missense_Mutation	p.E409D	3
MTRF1	BRCA	chr13	41834948	41834948	C	G	Missense_Mutation	p.Q32H	3
MTRF1	LIHC	chr13	41828685	41828685	T	-	Frame_Shift_Del	p.I163fs	3
MTRF1	UCS	chr13	41834816	41834816	C	A	Missense_Mutation	p.Q76H	3
MTRF1	LIHC	chr13	41834743	41834743	C	-	Frame_Shift_Del	p.E101fs	3
MTRF1	BLCA	chr13	41791298	41791298	C	G	Missense_Mutation	p.E431Q	3
MTRF1	HNSC	chr13	41826834	41826834	G	A	Missense_Mutation	p.S215L	3
MTRF1	LIHC	chr13	41800662	41800662	T	-	Frame_Shift_Del	p.N344fs	3
MTRF1	ESCA	chr13	41826879	41826879	C	T	Missense_Mutation		2
MTRF1	CESC	chr13	41814474	41814474	C	T	Missense_Mutation		2
MTRF1	ESCA	chr13	41834744	41834744	C	T	Silent		2
MTRF1	STAD	chr13	41834765	41834765	C	T	Silent	p.L93L	2
MTRF1	ESCA	chr13	41826879	41826879	C	T	Missense_Mutation	p.C200Y	2
MTRF1	SARC	chr13	41834665	41834665	C	T	Missense_Mutation		2
MTRF1	STAD	chr13	41834883	41834883	C	T	Missense_Mutation	p.S54N	2
MTRF1	CESC	chr13	41814474	41814474	C	T	Missense_Mutation	p.E265K	2
MTRF1	LUAD	chr13	41827091	41827091	T	C	Missense_Mutation	p.T195A	2
MTRF1	STAD	chr13	41800599	41800599	T	G	Missense_Mutation	p.K365T	2
MTRF1	UCEC	chr13	41797412	41797412	A	G	Missense_Mutation	p.Y402H	2
MTRF1	UCEC	chr13	41800663	41800663	T	G	Missense_Mutation	p.N344H	2
MTRF1	SKCM	chr13	41797443	41797443	G	A	Silent	p.T391T	2
MTRF1	STAD	chr13	41797467	41797467	C	T	Silent	p.E383E	2
MTRF1	UCEC	chr13	41800681	41800681	C	A	Nonsense_Mutation	p.E338*	2
MTRF1	SKCM	chr13	41797453	41797453	T	A	Missense_Mutation	p.Y388F	2
MTRF1	STAD	chr13	41808045	41808045	T	G	Missense_Mutation	p.R323S	2
MTRF1	BLCA	chr13	41791298	41791298	C	G	Missense_Mutation		2
MTRF1	KIRP	chr13	41791352	41791352	C	T	Missense_Mutation	p.G413S	2
MTRF1	UCEC	chr13	41808078	41808078	C	T	Silent	p.G312	2
MTRF1	LIHC	chr13	41791357	41791357	A	-	Frame_Shift_Del	p.L411fs	2
MTRF1	UCEC	chr13	41808104	41808104	T	C	Missense_Mutation	p.T304A	2
MTRF1	LIHC	chr13	41797447	41797447	A	-	Frame_Shift_Del	p.F390fs	2
MTRF1	PAAD	chr13	41791362	41791362	T	A	Missense_Mutation		2
MTRF1	BLCA	chr13	41797465	41797465	C	A	Missense_Mutation		2
MTRF1	UCEC	chr13	41834650	41834650	C	A	Nonsense_Mutation	p.E132*	2
MTRF1	LIHC	chr13	41827126	41827126	T	-	Frame_Shift_Del	p.N183fs	2
MTRF1	STAD	chr13	41826831	41826831	C	T	Missense_Mutation		1
MTRF1	ESCA	chr13	41826879	41826879	C	T	Missense_Mutation	p.C213Y	1
MTRF1	BLCA	chr13	41834938	41834938	C	G	Missense_Mutation		1
MTRF1	LGG	chr13	41814544	41814544	T	C	Silent	p.R241R	1
MTRF1	UCS	chr13	41834816	41834816	C	A	Missense_Mutation		1
MTRF1	SKCM	chr13	41800645	41800645	G	A	Missense_Mutation	p.R350C	1
MTRF1	UCEC	chr13	41808078	41808078	C	T	Silent	p.G325G	1
MTRF1	READ	chr13	41828724	41828724	C	A	Nonsense_Mutation	p.E150X	1
MTRF1	BLCA	chr13	41835046	41835046	C	G	Missense_Mutation		1
MTRF1	LGG	chr13	41834982	41834982	C	T	Missense_Mutation	p.C21Y	1
MTRF1	SKCM	chr13	41808047	41808047	T	G	Silent	p.R323R	1
MTRF1	UCEC	chr13	41797412	41797412	A	G	Missense_Mutation	p.Y415H	1
MTRF1	BLCA	chr13	41834874	41834874	C	A	Missense_Mutation		1
MTRF1	LGG	chr13	41814544	41814544	T	C	Silent		1
MTRF1	CESC	chr13	41834944	41834944	G	A	Missense_Mutation		1
MTRF1	LIHC	chr13	41800658	41800658	T	-	Frame_Shift_Del	p.K345fs	1
MTRF1	UCEC	chr13	41814568	41814568	A	G	Silent	p.G246_splice	1
MTRF1	BLCA	chr13	41834630	41834630	T	C	Silent		1
MTRF1	LGG	chr13	41834982	41834982	C	T	Missense_Mutation		1
MTRF1	SARC	chr13	41834665	41834665	C	T	Missense_Mutation	p.E127K	1
MTRF1	UCEC	chr13	41808098	41808098	G	A	Nonsense_Mutation	p.R319*	1
MTRF1	HNSC	chr13	41826834	41826834	G	A	Missense_Mutation		1
MTRF1	LIHC	chr13	41835024	41835024	A	G	Missense_Mutation		1
MTRF1	CESC	chr13	41834684	41834684	G	T	Nonsense_Mutation		1
MTRF1	LUAD	chr13	41814395	41814395	A	G	Splice_Site		1
MTRF1	HNSC	chr13	41826842	41826842	C	T	Silent		1
MTRF1	SARC	chr13	41834665	41834665	C	T	Missense_Mutation	p.E140K	1
MTRF1	BLCA	chr13	41808097	41808097	C	T	Missense_Mutation	p.R306Q	1
MTRF1	LIHC	chr13	41797468	41797468	T	C	Missense_Mutation		1
MTRF1	STAD	chr13	41834827	41834827	T	C	Missense_Mutation	p.K73E	1
MTRF1	CESC	chr13	41814474	41814474	C	T	Missense_Mutation	p.E278K	1
MTRF1	LUAD	chr13	41814395	41814395	A	G	Splice_Site	p.E290_splice	1
MTRF1	HNSC	chr13	41826842	41826842	C	T	Silent	p.Q212Q	1
MTRF1	BLCA	chr13	41834938	41834938	C	G	Missense_Mutation	p.D36H	1
MTRF1	LIHC	chr13	41835039	41835039	T	C	Missense_Mutation		1
MTRF1	CESC	chr13	41834684	41834684	G	T	Nonsense_Mutation	p.Y133*	1
MTRF1	LUSC	chr13	41828703	41828703	G	T	Missense_Mutation	p.Q170K	1
MTRF1	BLCA	chr13	41835046	41835046	C	G	Missense_Mutation	p.E13Q	1
MTRF1	COAD	chr13	41797486	41797486	C	T	Missense_Mutation	p.G377E	1
MTRF1	LUSC	chr13	41834927	41834927	C	A	Silent	p.L52L	1
MTRF1	SKCM	chr13	41834738	41834738	G	A	Silent	p.N102N	1
MTRF1	BLCA	chr13	41834874	41834874	C	A	Missense_Mutation	p.W57L	1
MTRF1	STAD	chr13	41834827	41834827	T	C	Missense_Mutation	p.K86E	1
MTRF1	ESCA	chr13	41826690	41826691	-	A	RNA	NULL	1
MTRF1	LUSC	chr13	41826881	41826881	G	A	Silent	p.I212I	1
MTRF1	BLCA	chr13	41808097	41808097	C	T	Missense_Mutation		1
MTRF1	KIRP	chr13	41791352	41791352	C	T	Silent	p.V461V	1
MTRF1	SKCM	chr13	41834968	41834968	G	A	Missense_Mutation	p.H26Y	1
MTRF1	BLCA	chr13	41834630	41834630	T	C	Splice_Site	p.K138K	1
MTRF1	STAD	chr13	41827154	41827154	G	T	Missense_Mutation	p.L174I	1
MTRF1	ESCA	chr13	41826691	41826691	A	-	RNA	NULL	1
MTRF1	KIRP	chr13	41791352	41791352	C	T	Missense_Mutation		1
MTRF1	SKCM	chr13	41834698	41834698	G	A	Missense_Mutation	p.L116F	1
MTRF1	BLCA	chr13	41834746	41834746	C	T	Missense_Mutation	p.E100K	1

Copy number variation (CNV) of MTRF1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MTRF1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
84911	N/A	BE645642	C4orf3	chr4	120218684	+	MTRF1	chr13	41811325	-
84911	N/A	AI525733	CLPTM1	chr19	45457571	-	MTRF1	chr13	41873356	-
84911	STAD	TCGA-EQ-A4SO-01A	FAM120A	chr9	96327703	+	MTRF1	chr13	41836172	-
84911	GBM	TCGA-27-1831-01A	FREM2	chr13	39438743	+	MTRF1	chr13	41808143	-
97902	N/A	BD237250	MTRF1	chr13	41848068	+	VMP1	chr17	57917332	+
84917	Non-Cancer	131Nd	SNX1	chr15	64415745	+	MTRF1	chr13	41835051	-
84911	N/A	BF216280	SUGT1P3	chr13	41488673	+	MTRF1	chr13	41865156	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
LGG	MTRF1	0.476183337793491	-0.741952335475408	0.0103281604123066	0.0118340303608926	0.010360565398333	525
LIHC	MTRF1	1.42359288304895	0.35318387537823	0.0253530605954308	0.0231118250437433	0.0252448674473513	417
LIHC	MTRF1	1.42359288304895	0.35318387537823	0.0253530605954308	0.0231118250437433	0.0252448674473513	417
THCA	MTRF1	0.171559250354104	-1.76282658892738	0.0276042928143707	0.0231063780861764	0.0262490190051646	571
THCA	MTRF1	0.171559250354104	-1.76282658892738	0.0276042928143707	0.0231063780861764	0.0262490190051646	571
BRCA	MTRF1	1.92560041300088	0.655237821965761	1.21066622607558e-05	1.63199488377346e-05	1.48898383932591e-05	1200

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MTRF1	0.000555996667117829	0.016
KIRP	MTRF1	0.00187572570607221	0.051

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	MTRF1	0.0142461963231723	0.46
PRAD	MTRF1	0.0142788411793317	0.46
BLCA	MTRF1	0.000394603072887689	0.013

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source