AARS2	Q5JTZ9	788	829	24	985	Chain	ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial
AARS2	Q5JTZ9	383	396	24	985	Chain	ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial
AARS2	Q5JTZ9	894	931	24	985	Chain	ID=PRO_0000250725;Note=Alanine--tRNA ligase%2C mitochondrial
ABCE1	P61221	506	546	1	599	Chain	ID=PRO_0000093316;Note=ATP-binding cassette sub-family E member 1
ABCE1	P61221	381	401	1	599	Chain	ID=PRO_0000093316;Note=ATP-binding cassette sub-family E member 1
ABCE1	P61221	506	546	342	562	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCE1	P61221	381	401	342	562	Domain	Note=ABC transporter 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABCE1	P61221	381	401	379	386	Nucleotide binding	Note=ATP 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434
ABTB1	Q969K4	175	214	1	478	Chain	ID=PRO_0000248267;Note=Ankyrin repeat and BTB/POZ domain-containing protein 1
ABTB1	Q969K4	254	287	1	478	Chain	ID=PRO_0000248267;Note=Ankyrin repeat and BTB/POZ domain-containing protein 1
ABTB1	Q969K4	287	343	1	478	Chain	ID=PRO_0000248267;Note=Ankyrin repeat and BTB/POZ domain-containing protein 1
ABTB1	Q969K4	175	214	115	182	Domain	Note=BTB 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ABTB1	Q969K4	254	287	272	346	Domain	Note=BTB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ABTB1	Q969K4	287	343	272	346	Domain	Note=BTB 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037
ABTB1	Q969K4	175	214	87	196	Alternative sequence	ID=VSP_052151;Note=In isoform 4. DYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQ->LCGHEE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABTB1	Q969K4	254	287	255	287	Alternative sequence	ID=VSP_052152;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ABTB1	Q969K4	287	343	255	287	Alternative sequence	ID=VSP_052152;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AGO1	Q9UL18	216	261	1	857	Chain	ID=PRO_0000194055;Note=Protein argonaute-1
AGO1	Q9UL18	216	261	226	346	Domain	Note=PAZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00142
AGO1	Q9UL18	216	261	242	242	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
AGO1	Q9UL18	216	261	208	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KRE
AGO1	Q9UL18	216	261	228	236	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KRE
AGO1	Q9UL18	216	261	241	243	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1SI2
AGO1	Q9UL18	216	261	250	260	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4KRE
AGO2	Q9UKV8	678	723	1	859	Chain	ID=PRO_0000194057;Note=Protein argonaute-2
AGO2	Q9UKV8	723	757	1	859	Chain	ID=PRO_0000194057;Note=Protein argonaute-2
AGO2	Q9UKV8	678	723	517	818	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03031
AGO2	Q9UKV8	723	757	517	818	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03031
AGO2	Q9UKV8	678	723	709	710	Region	Note=Interaction with guide RNA
AGO2	Q9UKV8	723	757	753	761	Region	Note=Interaction with guide RNA
AGO2	Q9UKV8	678	723	700	700	Modified residue	Note=4-hydroxyproline;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03031,ECO:0000269|PubMed:18690212;Dbxref=PMID:18690212
AGO2	Q9UKV8	723	757	724	757	Alternative sequence	ID=VSP_037001;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGO2	Q9UKV8	678	723	682	682	Mutagenesis	Note=No effect. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15284456;Dbxref=PMID:15284456
AGO2	Q9UKV8	678	723	683	683	Mutagenesis	Note=No effect on RNA cleavage. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800637;Dbxref=PMID:15800637
AGO2	Q9UKV8	678	723	700	700	Mutagenesis	Note=Reduced protein stability. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18690212;Dbxref=PMID:18690212
AGO2	Q9UKV8	678	723	704	704	Mutagenesis	Note=No effect. F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15284456;Dbxref=PMID:15284456
AGO2	Q9UKV8	723	757	744	744	Mutagenesis	Note=No effect. T->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15284456;Dbxref=PMID:15284456
AGO2	Q9UKV8	678	723	676	694	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	678	723	701	709	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	678	723	710	712	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4W5Q
AGO2	Q9UKV8	678	723	715	719	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	678	723	720	722	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	725	728	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	734	736	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	738	741	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	743	745	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	747	751	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z4D
AGO2	Q9UKV8	723	757	757	759	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CBD
AGO3	Q9H9G7	219	264	1	860	Chain	ID=PRO_0000194061;Note=Protein argonaute-3
AGO3	Q9H9G7	679	724	1	860	Chain	ID=PRO_0000194061;Note=Protein argonaute-3
AGO3	Q9H9G7	219	264	236	349	Domain	Note=PAZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03032
AGO3	Q9H9G7	679	724	518	819	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03032
AGO3	Q9H9G7	219	264	1	234	Alternative sequence	ID=VSP_041084;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AGO3	Q9H9G7	219	264	213	226	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	219	264	231	238	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	219	264	253	263	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	677	692	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	693	695	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	702	707	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	716	719	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO3	Q9H9G7	679	724	721	723	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5VM9
AGO4	Q9HCK5	725	759	1	861	Chain	ID=PRO_0000194063;Note=Protein argonaute-4
AGO4	Q9HCK5	725	759	509	820	Domain	Note=Piwi;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03033
AIMP1	Q12904	74	130	2	312	Chain	ID=PRO_0000223394;Note=Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
AIMP1	Q12904	74	130	2	312	Chain	ID=PRO_0000223394;Note=Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
AIMP1	Q12904	74	130	54	194	Region	Note=Interaction with HSP90B1;Ontology_term=ECO:0000250;evidence=ECO:0000250
AIMP1	Q12904	74	130	54	194	Region	Note=Interaction with HSP90B1;Ontology_term=ECO:0000250;evidence=ECO:0000250
AIMP1	Q12904	74	130	101	114	Region	Note=Required for endothelial cell death
AIMP1	Q12904	74	130	101	114	Region	Note=Required for endothelial cell death
AIMP1	Q12904	74	130	114	192	Region	Note=Required for endothelial cell migration
AIMP1	Q12904	74	130	114	192	Region	Note=Required for endothelial cell migration
AIMP1	Q12904	74	130	79	79	Natural variant	ID=VAR_025212;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7929199;Dbxref=dbSNP:rs1134648,PMID:7929199
AIMP1	Q12904	74	130	79	79	Natural variant	ID=VAR_025212;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7929199;Dbxref=dbSNP:rs1134648,PMID:7929199
AIMP1	Q12904	74	130	104	104	Natural variant	ID=VAR_029156;Note=T->A;Dbxref=dbSNP:rs113844295
AIMP1	Q12904	74	130	104	104	Natural variant	ID=VAR_029156;Note=T->A;Dbxref=dbSNP:rs113844295
AIMP1	Q12904	74	130	117	117	Natural variant	ID=VAR_050124;Note=T->A;Dbxref=dbSNP:rs2230255
AIMP1	Q12904	74	130	117	117	Natural variant	ID=VAR_050124;Note=T->A;Dbxref=dbSNP:rs2230255
AIRE	O43918	266	293	1	545	Chain	ID=PRO_0000064513;Note=Autoimmune regulator
AIRE	O43918	365	426	1	545	Chain	ID=PRO_0000064513;Note=Autoimmune regulator
AIRE	O43918	266	293	181	280	Domain	Note=SAND;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00185
AIRE	O43918	365	426	414	418	Motif	Note=LXXLL motif 3
AIRE	O43918	266	293	1	292	Alternative sequence	ID=VSP_004089;Note=In isoform 2%2C isoform 3 and isoform 4. MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLH->MWLVYSSGAPGTQQPARNRVFFPIGMAPGGVCWRPDGWGTGGQGRISGPGSMGAGQRLGSSGTQRCCWGSCFGKEVALRRVLHPS;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9398839;Dbxref=PMID:15489334,PMID:9398839
AIRE	O43918	266	293	293	293	Alternative sequence	ID=VSP_043529;Note=In isoform 4. Q->PVCMGVSCLCQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AIRE	O43918	365	426	377	545	Alternative sequence	ID=VSP_004090;Note=In isoform 3. VRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS->PRCQGWTPRPCTPYCVWVLRVSRTWLLVRVAGCAEMVRTCCGVLTAPLPSTGAATSQPAPPGPGRACAADPAQET;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9398839;Dbxref=PMID:9398839
AIRE	O43918	266	293	278	278	Natural variant	ID=VAR_005006;Note=S->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11524731,ECO:0000269|PubMed:12625412,ECO:0000269|PubMed:9717837;Dbxref=dbSNP:rs1800520,PMID:11524731,PMID:12625412,PMID:9717837
AIRE	O43918	365	426	423	426	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LRI
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	234	276	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	211	234	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	145	189	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	1	480	Chain	ID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	15	58	5	108	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	234	276	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	150	408	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	156	164	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	14	19	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	15	58	23	25	Region	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	211	234	228	230	Region	Note=Inhibitor binding
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	234	276	274	274	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	15	58	53	53	Binding site	Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	161	161	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	145	189	179	179	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	211	234	230	230	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	234	276	234	234	Binding site	Note=Inhibitor
AKT1	P31749	211	234	234	234	Binding site	Note=Inhibitor
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Modified residue	Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	1	62	Alternative sequence	ID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	17	17	Natural variant	ID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	15	58	25	25	Natural variant	ID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	145	189	167	167	Natural variant	ID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	17	17	Mutagenesis	Note=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	20	20	Mutagenesis	Note=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	15	58	25	25	Mutagenesis	Note=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	176	176	Mutagenesis	Note=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	145	189	173	174	Sequence conflict	Note=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	211	234	212	212	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	234	276	246	246	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	6	15	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	17	19	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	22	30	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	33	40	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	45	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	15	58	52	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	147	149	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	150	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	160	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	175	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	145	189	183	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	213	218	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	211	234	220	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	235	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT1	P31749	234	276	247	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
AKT2	P31751	213	236	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
AKT2	P31751	191	213	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
AKT2	P31751	277	320	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
AKT2	P31751	213	236	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT2	P31751	191	213	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT2	P31751	277	320	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
AKT2	P31751	213	236	230	232	Region	Note=Inhibitor binding
AKT2	P31751	277	320	277	279	Region	Note=Inhibitor binding
AKT2	P31751	277	320	292	293	Region	Note=Inhibitor binding
AKT2	P31751	277	320	280	280	Metal binding	Note=Manganese;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12434148;Dbxref=PMID:12434148
AKT2	P31751	277	320	293	293	Metal binding	Note=Manganese;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12434148;Dbxref=PMID:12434148
AKT2	P31751	191	213	200	200	Binding site	Note=Inhibitor
AKT2	P31751	213	236	232	232	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT2	P31751	213	236	236	236	Binding site	Note=Inhibitor
AKT2	P31751	277	320	279	279	Binding site	Note=Inhibitor%3B via carbonyl oxygen
AKT2	P31751	277	320	293	293	Binding site	Note=Inhibitor
AKT2	P31751	277	320	294	294	Binding site	Note=Inhibitor%3B via amide nitrogen
AKT2	P31751	277	320	309	309	Modified residue	Note=Phosphothreonine%3B by PDPK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12434148,ECO:0000269|PubMed:15890450,ECO:0000269|PubMed:20059950,ECO:0000269|PubMed:9512493;Dbxref=PMID:12434148,PMID:15890450,PMID:20059950,PMID:9512493
AKT2	P31751	277	320	306	306	Glycosylation	Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKT2	P31751	277	320	313	313	Glycosylation	Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250
AKT2	P31751	277	320	297	311	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12517337;Dbxref=PMID:12517337
AKT2	P31751	277	320	278	320	Alternative sequence	ID=VSP_056930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
AKT2	P31751	191	213	208	208	Natural variant	ID=VAR_040357;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35817154,PMID:17344846
AKT2	P31751	277	320	309	309	Mutagenesis	Note=Impairs interaction with TTC3%3B when associated with A-474. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15890450,ECO:0000269|PubMed:20059950;Dbxref=PMID:15890450,PMID:20059950
AKT2	P31751	277	320	309	309	Mutagenesis	Note=Constitutively active%3B when associated with D-474. T->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15890450,ECO:0000269|PubMed:20059950;Dbxref=PMID:15890450,PMID:20059950
AKT2	P31751	191	213	194	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	213	236	215	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	213	236	222	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	280	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	289	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	298	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2UW9
AKT2	P31751	277	320	310	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JDO
AKT2	P31751	277	320	314	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
AKT2	P31751	277	320	319	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1O6L
APEH	P13798	507	534	1	732	Chain	ID=PRO_0000122430;Note=Acylamino-acid-releasing enzyme
APEH	P13798	479	507	1	732	Chain	ID=PRO_0000122430;Note=Acylamino-acid-releasing enzyme
APEH	P13798	202	248	1	732	Chain	ID=PRO_0000122430;Note=Acylamino-acid-releasing enzyme
ASCC2	Q9H1I8	523	562	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	278	302	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	27	80	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	523	562	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	278	302	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	27	80	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
ASCC2	Q9H1I8	27	80	1	114	Alternative sequence	ID=VSP_011009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	27	80	1	114	Alternative sequence	ID=VSP_011009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	27	80	28	80	Alternative sequence	ID=VSP_045878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	27	80	28	80	Alternative sequence	ID=VSP_045878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	523	562	485	757	Alternative sequence	ID=VSP_011011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	523	562	485	757	Alternative sequence	ID=VSP_011011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ASCC2	Q9H1I8	523	562	546	546	Natural variant	ID=VAR_050677;Note=D->G;Dbxref=dbSNP:rs34833047
ASCC2	Q9H1I8	523	562	546	546	Natural variant	ID=VAR_050677;Note=D->G;Dbxref=dbSNP:rs34833047
ASCC2	Q9H1I8	523	562	526	526	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC2	Q9H1I8	523	562	526	526	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC3	Q8N3C0	579	634	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	1850	1925	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	1025	1084	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	423	465	1	2202	Chain	ID=PRO_0000102093;Note=Activating signal cointegrator 1 complex subunit 3
ASCC3	Q8N3C0	579	634	486	669	Domain	Note=Helicase ATP-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
ASCC3	Q8N3C0	1025	1084	978	1287	Domain	Note=SEC63 1
ASCC3	Q8N3C0	1850	1925	1812	2176	Domain	Note=SEC63 2
ASCC3	Q8N3C0	579	634	611	614	Motif	Note=DEVH box
ASCC3	Q8N3C0	579	634	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	1850	1925	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	1025	1084	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	423	465	112	2202	Alternative sequence	ID=VSP_042956;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
ASCC3	Q8N3C0	1850	1925	732	2202	Alternative sequence	ID=VSP_042958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASCC3	Q8N3C0	1025	1084	732	2202	Alternative sequence	ID=VSP_042958;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ASCC3	Q8N3C0	1025	1084	1050	1050	Natural variant	ID=VAR_034860;Note=V->I;Dbxref=dbSNP:rs9497983
ASCC3	Q8N3C0	423	465	444	444	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
ASCC3	Q8N3C0	579	634	582	582	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
ATXN2	Q99700	276	300	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	423	488	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	548	618	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	679	745	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	1105	1123	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	1172	1248	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	276	300	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	423	488	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	548	618	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	679	745	1	1313	Chain	ID=PRO_0000064756;Note=Ataxin-2
ATXN2	Q99700	548	618	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	679	745	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	548	618	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	679	745	551	734	Compositional bias	Note=Pro-rich
ATXN2	Q99700	423	488	466	466	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ATXN2	Q99700	423	488	466	466	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
ATXN2	Q99700	423	488	478	478	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATXN2	Q99700	423	488	478	478	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ATXN2	Q99700	548	618	554	554	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	548	618	554	554	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	679	745	684	684	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
ATXN2	Q99700	679	745	684	684	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163
ATXN2	Q99700	679	745	728	728	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ATXN2	Q99700	679	745	728	728	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
ATXN2	Q99700	679	745	741	741	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	679	745	741	741	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
ATXN2	Q99700	276	300	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	423	488	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	548	618	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	679	745	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	276	300	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	423	488	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	548	618	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	679	745	1	981	Alternative sequence	ID=VSP_011574;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	276	300	277	300	Alternative sequence	ID=VSP_057286;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATXN2	Q99700	276	300	277	300	Alternative sequence	ID=VSP_057286;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATXN2	Q99700	1105	1123	996	1313	Alternative sequence	ID=VSP_011577;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8896557;Dbxref=PMID:8896557
ATXN2	Q99700	1172	1248	996	1313	Alternative sequence	ID=VSP_011577;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8896557;Dbxref=PMID:8896557
ATXN2	Q99700	1105	1123	1106	1124	Alternative sequence	ID=VSP_057287;Note=In isoform 5. ACPKLPYNKETSPSFYFAI->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
ATXN2	Q99700	1105	1123	1106	1123	Alternative sequence	ID=VSP_011578;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ATXN2	Q99700	1172	1248	1244	1313	Alternative sequence	ID=VSP_011582;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANK1	Q8NDB2	531	633	1	785	Chain	ID=PRO_0000251927;Note=B-cell scaffold protein with ankyrin repeats
BANK1	Q8NDB2	23	156	1	785	Chain	ID=PRO_0000251927;Note=B-cell scaffold protein with ankyrin repeats
BANK1	Q8NDB2	23	156	1	154	Region	Note=Interaction with ITPR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11782428;Dbxref=PMID:11782428
BANK1	Q8NDB2	23	156	1	30	Alternative sequence	ID=VSP_020803;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11782428,ECO:0000303|PubMed:14702039;Dbxref=PMID:11782428,PMID:14702039
BANK1	Q8NDB2	23	156	15	23	Alternative sequence	ID=VSP_020805;Note=In isoform 2. PAPCGPAPP->MVNCHLKI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BANK1	Q8NDB2	23	156	24	156	Alternative sequence	ID=VSP_034214;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:18204447;Dbxref=PMID:18204447
BANK1	Q8NDB2	23	156	61	61	Natural variant	ID=VAR_027729;Note=Polymorphism%3B may influence susceptibility to SLE. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18204447;Dbxref=dbSNP:rs10516487,PMID:18204447
BANK1	Q8NDB2	23	156	143	143	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
BANK1	Q8NDB2	531	633	557	557	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
BCL3	P20749	271	297	1	454	Chain	ID=PRO_0000066976;Note=B-cell lymphoma 3 protein
BCL3	P20749	297	353	1	454	Chain	ID=PRO_0000066976;Note=B-cell lymphoma 3 protein
BCL3	P20749	271	297	275	304	Repeat	Note=ANK 5
BCL3	P20749	297	353	275	304	Repeat	Note=ANK 5
BCL3	P20749	297	353	308	337	Repeat	Note=ANK 6
BCL3	P20749	297	353	338	367	Repeat	Note=ANK 7
BCL3	P20749	271	297	273	275	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	271	297	279	285	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	271	297	289	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	289	297	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	312	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	322	330	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	345	348	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BCL3	P20749	297	353	352	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1K1A
BOLL	Q8N9W6	160	184	1	283	Chain	ID=PRO_0000081494;Note=Protein boule-like
BOLL	Q8N9W6	160	184	1	283	Chain	ID=PRO_0000081494;Note=Protein boule-like
BOLL	Q8N9W6	160	184	164	194	Domain	Note=DAZ-like
BOLL	Q8N9W6	160	184	164	194	Domain	Note=DAZ-like
BOLL	Q8N9W6	160	184	184	184	Alternative sequence	ID=VSP_009445;Note=In isoform 2. Q->QGIKQCHTRRWMDSLLPFTKCDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BOLL	Q8N9W6	160	184	184	184	Alternative sequence	ID=VSP_009445;Note=In isoform 2. Q->QGIKQCHTRRWMDSLLPFTKCDE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BOLL	Q8N9W6	160	184	164	164	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
BOLL	Q8N9W6	160	184	164	164	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
BZW1	Q7L1Q6	21	80	1	419	Chain	ID=PRO_0000254609;Note=Basic leucine zipper and W2 domain-containing protein 1
BZW1	Q7L1Q6	112	134	1	419	Chain	ID=PRO_0000254609;Note=Basic leucine zipper and W2 domain-containing protein 1
BZW1	Q7L1Q6	368	409	1	419	Chain	ID=PRO_0000254609;Note=Basic leucine zipper and W2 domain-containing protein 1
BZW1	Q7L1Q6	368	409	247	414	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
BZW1	Q7L1Q6	368	409	368	368	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
BZW2	Q9Y6E2	19	78	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	217	274	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	19	78	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	217	274	1	419	Chain	ID=PRO_0000254618;Note=Basic leucine zipper and W2 domain-containing protein 2
BZW2	Q9Y6E2	217	274	248	415	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
BZW2	Q9Y6E2	217	274	248	415	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
BZW2	Q9Y6E2	217	274	202	419	Alternative sequence	ID=VSP_055569;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BZW2	Q9Y6E2	217	274	202	419	Alternative sequence	ID=VSP_055569;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
BZW2	Q9Y6E2	19	78	44	44	Natural variant	ID=VAR_033642;Note=D->A;Dbxref=dbSNP:rs35233079
BZW2	Q9Y6E2	19	78	44	44	Natural variant	ID=VAR_033642;Note=D->A;Dbxref=dbSNP:rs35233079
C1QBP	Q07021	159	192	74	282	Chain	ID=PRO_0000018590;Note=Complement component 1 Q subcomponent-binding protein%2C mitochondrial
C1QBP	Q07021	159	192	168	213	Region	Note=Interaction with MAVS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19164550;Dbxref=PMID:19164550
C1QBP	Q07021	159	192	188	188	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:19690332;Dbxref=PMID:17693683,PMID:19690332
C1QBP	Q07021	159	192	186	186	Natural variant	ID=VAR_080391;Note=In COXPD33%3B unknown pathological significance. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28942965;Dbxref=dbSNP:rs748497469,PMID:28942965
C1QBP	Q07021	159	192	188	188	Natural variant	ID=VAR_080392;Note=In COXPD33%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28942965;Dbxref=PMID:28942965
C1QBP	Q07021	159	192	168	174	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P32
C1QBP	Q07021	159	192	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P32
C1QBP	Q07021	159	192	180	187	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P32
CALR	P27797	30	64	18	417	Chain	ID=PRO_0000004173;Note=Calreticulin
CALR	P27797	272	320	18	417	Chain	ID=PRO_0000004173;Note=Calreticulin
CALR	P27797	64	132	18	417	Chain	ID=PRO_0000004173;Note=Calreticulin
CALR	P27797	272	320	273	283	Repeat	Note=2-2
CALR	P27797	272	320	287	297	Repeat	Note=2-3
CALR	P27797	30	64	18	197	Region	Note=N-domain
CALR	P27797	64	132	18	197	Region	Note=N-domain
CALR	P27797	272	320	198	308	Region	Note=P-domain
CALR	P27797	272	320	259	297	Region	Note=3 X approximate repeats
CALR	P27797	272	320	309	417	Region	Note=C-domain
CALR	P27797	30	64	62	62	Metal binding	Note=Calcium%3B via carbonyl oxygen
CALR	P27797	30	64	64	64	Metal binding	Note=Calcium%3B via carbonyl oxygen
CALR	P27797	64	132	64	64	Metal binding	Note=Calcium%3B via carbonyl oxygen
CALR	P27797	64	132	109	109	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	64	132	111	111	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	64	132	128	128	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	272	320	317	317	Binding site	Note=Carbohydrate;Ontology_term=ECO:0000250;evidence=ECO:0000250
CALR	P27797	30	64	48	48	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
CALR	P27797	64	132	105	137	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11322874,ECO:0000269|PubMed:21423620;Dbxref=PMID:11322874,PMID:21423620
CALR	P27797	30	64	30	35	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	42	44	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	49	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	30	64	60	63	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	65	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	70	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	91	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	104	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	119	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	64	132	129	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CALR	P27797	272	320	303	306	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5LK5
CALR	P27797	272	320	311	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3POW
CAPRIN1	Q14444	468	518	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	293	322	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	229	275	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	468	518	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	293	322	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	229	275	2	709	Chain	ID=PRO_0000087549;Note=Caprin-1
CAPRIN1	Q14444	229	275	263	263	Natural variant	ID=VAR_042425;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7657653;Dbxref=dbSNP:rs1132973,PMID:7657653
CAPRIN1	Q14444	229	275	263	263	Natural variant	ID=VAR_042425;Note=A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7657653;Dbxref=dbSNP:rs1132973,PMID:7657653
CAPRIN1	Q14444	229	275	230	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
CAPRIN1	Q14444	229	275	230	242	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
CAPRIN1	Q14444	229	275	245	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
CAPRIN1	Q14444	229	275	245	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WBE
CARS2	Q9HA77	190	218	191	218	Natural variant	ID=VAR_075667;Note=In COXPD27. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25361775;Dbxref=PMID:25361775
CARS2	Q9HA77	190	218	217	217	Natural variant	ID=VAR_075668;Note=In COXPD27. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25787132;Dbxref=PMID:25787132
CARS2	Q9HA77	439	472	440	440	Natural variant	ID=VAR_034523;Note=E->K;Dbxref=dbSNP:rs965189
CARS2	Q9HA77	190	218	182	202	Sequence conflict	Note=RGNAYSTAKGNVYFDLKSRGD->SWERLFNGKRQCLLRSESLEET;Ontology_term=ECO:0000305;evidence=ECO:0000305
CARS2	Q9HA77	190	218	207	223	Sequence conflict	Note=LVGVVPGPVGEPADSDK->IGRRGPWSSPETSGLLTS;Ontology_term=ECO:0000305;evidence=ECO:0000305
CASC3	O15234	550	583	1	703	Chain	ID=PRO_0000089324;Note=Protein CASC3
CASC3	O15234	203	261	1	703	Chain	ID=PRO_0000089324;Note=Protein CASC3
CASC3	O15234	203	261	137	283	Region	Note=Necessary for RNA-binding%2C interaction with MAGOH and localization in nucleus speckles;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15166247;Dbxref=PMID:15166247
CASC3	O15234	203	261	137	283	Region	Note=Sufficient to form the EJC
CASC3	O15234	550	583	377	703	Region	Note=Necessary for localization in cytoplasmic stress granules
CASC3	O15234	203	261	204	210	Motif	Note=Nuclear localization signal 1;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASC3	O15234	203	261	254	262	Motif	Note=Nuclear localization signal 2;Ontology_term=ECO:0000255;evidence=ECO:0000255
CASC3	O15234	203	261	218	218	Mutagenesis	Note=Abolishes interaction with EIF4A3%2C EJC formation and localization in nucleus speckles. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16170325;Dbxref=PMID:16170325
CASC3	O15234	203	261	220	221	Mutagenesis	Note=Abolishes interaction with EIF4A3%2C EJC formation and localization in nucleus speckles. HD->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16170325;Dbxref=PMID:16170325
CASC3	O15234	203	261	240	241	Mutagenesis	Note=Abolishes interaction with EIF4A3%2C EJC formation and localization in nucleus speckles. YG->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16170325;Dbxref=PMID:16170325
CASC3	O15234	203	261	226	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0S
CASC3	O15234	203	261	233	240	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HYI
CASC3	O15234	203	261	244	246	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EX7
CDC123	O75794	239	282	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	188	229	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	25	48	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	79	111	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	282	328	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	68	79	1	336	Chain	ID=PRO_0000228662;Note=Cell division cycle protein 123 homolog
CDC123	O75794	79	111	93	93	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDC123	O75794	282	328	317	317	Sequence conflict	Note=E->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
CDKAL1	Q5VV42	412	433	1	579	Chain	ID=PRO_0000298670;Note=Threonylcarbamoyladenosine tRNA methylthiotransferase
CDKAL1	Q5VV42	412	433	1	579	Chain	ID=PRO_0000298670;Note=Threonylcarbamoyladenosine tRNA methylthiotransferase
CDKAL1	Q5VV42	412	433	431	493	Domain	Note=TRAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00208
CDKAL1	Q5VV42	412	433	431	493	Domain	Note=TRAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00208
CDKAL1	Q5VV42	412	433	98	579	Alternative sequence	ID=VSP_027452;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CDKAL1	Q5VV42	412	433	98	579	Alternative sequence	ID=VSP_027452;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CDKAL1	Q5VV42	412	433	413	433	Alternative sequence	ID=VSP_027453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CDKAL1	Q5VV42	412	433	413	433	Alternative sequence	ID=VSP_027453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
CELF1	Q92879	103	148	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	254	297	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	297	334	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	396	444	1	486	Chain	ID=PRO_0000081538;Note=CUGBP Elav-like family member 1
CELF1	Q92879	103	148	108	188	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF1	Q92879	396	444	401	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF1	Q92879	254	297	287	308	Compositional bias	Note=Ser-rich
CELF1	Q92879	297	334	287	308	Compositional bias	Note=Ser-rich
CELF1	Q92879	297	334	302	302	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P28659
CELF1	Q92879	103	148	109	109	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
CELF1	Q92879	103	148	104	104	Alternative sequence	ID=VSP_026788;Note=In isoform 4%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.6;Dbxref=PMID:14702039
CELF1	Q92879	254	297	297	297	Alternative sequence	ID=VSP_005785;Note=In isoform 3. S->SA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11686919,ECO:0000303|PubMed:15489334;Dbxref=PMID:11686919,PMID:15489334
CELF1	Q92879	297	334	297	297	Alternative sequence	ID=VSP_005785;Note=In isoform 3. S->SA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11686919,ECO:0000303|PubMed:15489334;Dbxref=PMID:11686919,PMID:15489334
CELF1	Q92879	297	334	331	331	Mutagenesis	Note=Does not reduce RNA-binding%3B when associated with L-63 and F-472. Abolishes ARE/EDEN-dependent deadenylation%3B when associated with D-331 and F-472. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12799066;Dbxref=PMID:12799066
CELF1	Q92879	103	148	105	107	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	108	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	121	128	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	129	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	134	141	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	103	148	143	145	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHS
CELF1	Q92879	103	148	147	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3NMR
CELF1	Q92879	396	444	399	401	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RQC
CELF1	Q92879	396	444	403	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	414	421	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	422	424	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	428	434	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	436	438	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF1	Q92879	396	444	440	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPZ
CELF4	Q9BZC1	416	444	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	388	416	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	416	444	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	388	416	1	486	Chain	ID=PRO_0000295221;Note=CUGBP Elav-like family member 4
CELF4	Q9BZC1	416	444	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	388	416	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	416	444	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	388	416	404	479	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CELF4	Q9BZC1	388	416	388	389	Alternative sequence	ID=VSP_026831;Note=In isoform 2. GP->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CELF4	Q9BZC1	388	416	388	389	Alternative sequence	ID=VSP_026831;Note=In isoform 2. GP->A;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
CELF4	Q9BZC1	416	444	417	444	Alternative sequence	ID=VSP_026832;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10893231,ECO:0000303|PubMed:15489334;Dbxref=PMID:10893231,PMID:15489334
CELF4	Q9BZC1	416	444	417	444	Alternative sequence	ID=VSP_026832;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10893231,ECO:0000303|PubMed:15489334;Dbxref=PMID:10893231,PMID:15489334
CELF4	Q9BZC1	388	416	388	388	Natural variant	ID=VAR_052203;Note=G->S;Dbxref=dbSNP:rs12458669
CELF4	Q9BZC1	388	416	388	388	Natural variant	ID=VAR_052203;Note=G->S;Dbxref=dbSNP:rs12458669
CNOT11	Q9UKZ1	226	277	1	510	Chain	ID=PRO_0000089357;Note=CCR4-NOT transcription complex subunit 11
CNOT7	Q9UIV1	206	243	1	285	Chain	ID=PRO_0000212844;Note=CCR4-NOT transcription complex subunit 7
CNOT7	Q9UIV1	104	157	1	285	Chain	ID=PRO_0000212844;Note=CCR4-NOT transcription complex subunit 7
CNOT7	Q9UIV1	206	243	230	230	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT7	Q9UIV1	104	157	138	138	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with Y-142 and K-149. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	104	157	141	141	Mutagenesis	Note=Abolishes interaction with CNOT1. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	104	157	142	142	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with K-138 and K-149. T->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	104	157	149	149	Mutagenesis	Note=Abolishes interaction with CNOT1%3B when associated with K-138 and Y-142. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22977175;Dbxref=PMID:22977175
CNOT7	Q9UIV1	206	243	225	225	Mutagenesis	Note=Abolishes RNA deadenylase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19276069;Dbxref=PMID:19276069
CNOT7	Q9UIV1	206	243	230	230	Mutagenesis	Note=Abolishes RNA deadenylase activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19276069;Dbxref=PMID:19276069
CNOT7	Q9UIV1	206	243	241	241	Sequence conflict	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
CNOT7	Q9UIV1	104	157	103	105	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	110	119	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	123	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	133	141	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	142	144	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	145	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	104	157	152	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	206	243	209	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
CNOT7	Q9UIV1	206	243	227	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2D5R
COPS5	Q92905	126	169	2	334	Chain	ID=PRO_0000194835;Note=COP9 signalosome complex subunit 5
COPS5	Q92905	126	169	55	192	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	138	151	Motif	Note=JAMM motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	138	138	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	140	140	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	151	151	Metal binding	Note=Zinc%3B catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
COPS5	Q92905	126	169	138	138	Mutagenesis	Note=Abolishes ability to deneddylate cullins%2C without affecting the 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19214193;Dbxref=PMID:19214193
COPS5	Q92905	126	169	129	129	Sequence conflict	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
COPS5	Q92905	126	169	111	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	132	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	141	143	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	149	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
COPS5	Q92905	126	169	166	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JOH
CPEB3	Q8NE35	454	484	1	698	Chain	ID=PRO_0000269261;Note=Cytoplasmic polyadenylation element-binding protein 3
CPEB3	Q8NE35	454	484	441	532	Domain	Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
CPEB3	Q8NE35	454	484	463	463	Mutagenesis	Note=Does not impair RNA binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	470	470	Mutagenesis	Note=Does not impair RNA binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	474	474	Mutagenesis	Note=Does not impair RNA binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	479	479	Mutagenesis	Note=Does not impair RNA binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24343026;Dbxref=PMID:24343026
CPEB3	Q8NE35	454	484	454	460	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	454	484	461	464	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	454	484	467	470	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RUG
CPEB3	Q8NE35	454	484	474	477	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DNL
CPEB3	Q8NE35	454	484	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RUG
CPEB4	Q17RY0	402	419	1	729	Chain	ID=PRO_0000269264;Note=Cytoplasmic polyadenylation element-binding protein 4
CPEB4	Q17RY0	402	419	403	419	Alternative sequence	ID=VSP_022041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11214970,ECO:0000303|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334
CPEB4	Q17RY0	402	419	404	428	Alternative sequence	ID=VSP_022042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DALRD3	Q5D0E6	481	504	1	543	Chain	ID=PRO_0000315848;Note=DALR anticodon-binding domain-containing protein 3
DALRD3	Q5D0E6	443	481	1	543	Chain	ID=PRO_0000315848;Note=DALR anticodon-binding domain-containing protein 3
DALRD3	Q5D0E6	481	504	139	543	Alternative sequence	ID=VSP_030744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DALRD3	Q5D0E6	443	481	139	543	Alternative sequence	ID=VSP_030744;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DALRD3	Q5D0E6	481	504	444	543	Alternative sequence	ID=VSP_030746;Note=In isoform 2. GEWLLLFNSILPFPDLLSRTAVLDCTAPGLHIAVRTEMICKFLVQLSMDFSSYYNRVHILGEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGLPPLSHI->YPPLSGSAEPDSSAGLHSPGAPHCCTHRDDMQVPGTAQHGFQLLLQPGTHPGGASTTPLWSDVRPPAASESCA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DALRD3	Q5D0E6	443	481	444	543	Alternative sequence	ID=VSP_030746;Note=In isoform 2. GEWLLLFNSILPFPDLLSRTAVLDCTAPGLHIAVRTEMICKFLVQLSMDFSSYYNRVHILGEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGLPPLSHI->YPPLSGSAEPDSSAGLHSPGAPHCCTHRDDMQVPGTAQHGFQLLLQPGTHPGGASTTPLWSDVRPPAASESCA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAPK1	P53355	306	337	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	804	870	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	21	94	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	377	410	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	608	641	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	741	804	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	306	337	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	804	870	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	21	94	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	377	410	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	608	641	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	741	804	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	306	337	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	804	870	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	21	94	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	377	410	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	608	641	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	741	804	1	1430	Chain	ID=PRO_0000085910;Note=Death-associated protein kinase 1
DAPK1	P53355	21	94	13	275	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DAPK1	P53355	21	94	13	275	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DAPK1	P53355	21	94	13	275	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
DAPK1	P53355	377	410	378	407	Repeat	Note=ANK 1
DAPK1	P53355	377	410	378	407	Repeat	Note=ANK 1
DAPK1	P53355	377	410	378	407	Repeat	Note=ANK 1
DAPK1	P53355	608	641	609	638	Repeat	Note=ANK 8
DAPK1	P53355	608	641	609	638	Repeat	Note=ANK 8
DAPK1	P53355	608	641	609	638	Repeat	Note=ANK 8
DAPK1	P53355	804	870	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	741	804	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	804	870	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	741	804	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	804	870	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	741	804	681	955	Domain	Note=Roc;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00758
DAPK1	P53355	21	94	19	27	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	19	27	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	19	27	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	94	96	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	94	96	Nucleotide binding	Note=ATP
DAPK1	P53355	21	94	94	96	Nucleotide binding	Note=ATP
DAPK1	P53355	306	337	267	334	Region	Note=Calmodulin-binding
DAPK1	P53355	306	337	267	334	Region	Note=Calmodulin-binding
DAPK1	P53355	306	337	267	334	Region	Note=Calmodulin-binding
DAPK1	P53355	21	94	42	42	Binding site	Note=ATP
DAPK1	P53355	21	94	42	42	Binding site	Note=ATP
DAPK1	P53355	21	94	42	42	Binding site	Note=ATP
DAPK1	P53355	306	337	308	308	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
DAPK1	P53355	306	337	308	308	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
DAPK1	P53355	306	337	308	308	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:15729359,ECO:0000269|PubMed:17056602;Dbxref=PMID:11579085,PMID:15729359,PMID:17056602
DAPK1	P53355	306	337	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DAPK1	P53355	306	337	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DAPK1	P53355	306	337	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
DAPK1	P53355	306	337	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
DAPK1	P53355	306	337	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
DAPK1	P53355	306	337	333	333	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:24275569
DAPK1	P53355	306	337	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	21	94	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	377	410	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	306	337	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	21	94	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	377	410	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	306	337	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	21	94	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	377	410	1	446	Alternative sequence	ID=VSP_042053;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	742	783	Alternative sequence	ID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	742	783	Alternative sequence	ID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	742	783	Alternative sequence	ID=VSP_042054;Note=In isoform 2. VSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHH->GRNLHAGPVSPAGVGFRTLSFQGLGGKGVVFGSLGLYWTLWP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	741	804	784	1430	Alternative sequence	ID=VSP_042055;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DAPK1	P53355	804	870	805	870	Alternative sequence	ID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAPK1	P53355	804	870	805	870	Alternative sequence	ID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAPK1	P53355	804	870	805	870	Alternative sequence	ID=VSP_054478;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAPK1	P53355	608	641	622	622	Natural variant	ID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
DAPK1	P53355	608	641	622	622	Natural variant	ID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
DAPK1	P53355	608	641	622	622	Natural variant	ID=VAR_060694;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs36215047
DAPK1	P53355	21	94	42	42	Mutagenesis	Note=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
DAPK1	P53355	21	94	42	42	Mutagenesis	Note=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
DAPK1	P53355	21	94	42	42	Mutagenesis	Note=Loss of activity%2C apoptotic function and of autophosphorylation. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11579085,ECO:0000269|PubMed:7828849;Dbxref=PMID:11579085,PMID:7828849
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Elevated Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Increases apoptotic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	308	308	Mutagenesis	Note=Reduced Ca(2+)-calmodulin binding and Ca(2+)-calmodulin-independent kinase activity. Decreases apoptotic activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	313	313	Mutagenesis	Note=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	313	313	Mutagenesis	Note=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	306	337	313	313	Mutagenesis	Note=Minimal effect on activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11579085;Dbxref=PMID:11579085
DAPK1	P53355	21	94	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	13	21	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	23	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	23	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	23	32	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	33	35	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	33	35	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	33	35	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	38	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	38	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	38	46	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
DAPK1	P53355	21	94	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
DAPK1	P53355	21	94	48	51	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2W4J
DAPK1	P53355	21	94	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	53	56	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	58	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	58	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	58	70	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	79	84	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	21	94	86	94	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4PF4
DAPK1	P53355	306	337	304	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
DAPK1	P53355	306	337	304	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
DAPK1	P53355	306	337	304	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1YR5
DARS2	Q6PI48	132	164	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	98	132	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	521	558	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	376	397	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	340	376	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	397	448	48	645	Chain	ID=PRO_0000250736;Note=Aspartate--tRNA ligase%2C mitochondrial
DARS2	Q6PI48	521	558	535	535	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
DARS2	Q6PI48	521	558	542	542	Binding site	Note=Aspartate;Ontology_term=ECO:0000250;evidence=ECO:0000250
DARS2	Q6PI48	376	397	382	382	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
DARS2	Q6PI48	132	164	152	152	Natural variant	ID=VAR_037016;Note=In LBSL. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17384640;Dbxref=dbSNP:rs121918208,PMID:17384640
DAZ1	Q9NQZ3	642	666	1	744	Chain	ID=PRO_0000081554;Note=Deleted in azoospermia protein 1
DAZ1	Q9NQZ3	642	666	1	744	Chain	ID=PRO_0000081554;Note=Deleted in azoospermia protein 1
DAZ1	Q9NQZ3	642	666	1	744	Chain	ID=PRO_0000081554;Note=Deleted in azoospermia protein 1
DAZ1	Q9NQZ3	642	666	1	744	Chain	ID=PRO_0000081554;Note=Deleted in azoospermia protein 1
DAZ1	Q9NQZ3	642	666	644	664	Domain	Note=DAZ-like 7
DAZ1	Q9NQZ3	642	666	644	664	Domain	Note=DAZ-like 7
DAZ1	Q9NQZ3	642	666	644	664	Domain	Note=DAZ-like 7
DAZ1	Q9NQZ3	642	666	644	664	Domain	Note=DAZ-like 7
DAZ1	Q9NQZ3	642	666	614	744	Alternative sequence	ID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAZ1	Q9NQZ3	642	666	614	744	Alternative sequence	ID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAZ1	Q9NQZ3	642	666	614	744	Alternative sequence	ID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAZ1	Q9NQZ3	642	666	614	744	Alternative sequence	ID=VSP_056240;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	1	558	Chain	ID=PRO_0000081555;Note=Deleted in azoospermia protein 2
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	314	334	Domain	Note=DAZ-like 7
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	338	358	Domain	Note=DAZ-like 8
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	198	389	Alternative sequence	ID=VSP_009452;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7670487;Dbxref=PMID:7670487
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	321	344	Alternative sequence	ID=VSP_009453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:15489334
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	341	341	Sequence conflict	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DAZ2	Q13117	326	350	344	344	Sequence conflict	Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
DCPS	Q96C86	174	212	2	337	Chain	ID=PRO_0000109794;Note=m7GpppX diphosphatase
DCPS	Q96C86	174	212	175	175	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	185	185	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	205	205	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	207	207	Binding site	Note=Substrate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15068804,ECO:0000269|PubMed:15769464;Dbxref=PMID:15068804,PMID:15769464
DCPS	Q96C86	174	212	175	175	Mutagenesis	Note=Loss of decapping activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	185	185	Mutagenesis	Note=Loss of decapping activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	204	204	Mutagenesis	Note=Reduces decapping activity. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	205	205	Mutagenesis	Note=Reduces decapping activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	206	206	Mutagenesis	Note=No effect. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	207	207	Mutagenesis	Note=Reduces decapping activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	207	207	Mutagenesis	Note=No effect. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15068804;Dbxref=PMID:15068804
DCPS	Q96C86	174	212	174	180	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	183	185	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	186	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	196	198	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DCPS	Q96C86	174	212	200	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BL9
DDX1	Q92499	339	372	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	102	130	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	44	54	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	402	465	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	339	372	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	102	130	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	44	54	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	402	465	1	740	Chain	ID=PRO_0000054986;Note=ATP-dependent RNA helicase DDX1
DDX1	Q92499	339	372	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	102	130	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	44	54	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	402	465	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	339	372	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	102	130	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	44	54	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	402	465	2	428	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX1	Q92499	102	130	70	247	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
DDX1	Q92499	102	130	70	247	Domain	Note=B30.2/SPRY;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00548
DDX1	Q92499	44	54	46	53	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX1	Q92499	44	54	46	53	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX1	Q92499	339	372	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	102	130	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	44	54	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	402	465	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	339	372	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	102	130	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	44	54	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	402	465	1	525	Region	Note=Necessary for interaction with RELA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19058135;Dbxref=PMID:19058135
DDX1	Q92499	339	372	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	102	130	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	44	54	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	402	465	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	339	372	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	102	130	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	44	54	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	402	465	1	448	Region	Note=Interaction with dsRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q91VR5
DDX1	Q92499	102	130	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	44	54	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	102	130	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	44	54	1	295	Region	Note=Necessary for interaction with HNRNPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12183465;Dbxref=PMID:12183465
DDX1	Q92499	339	372	370	373	Motif	Note=DEAD box
DDX1	Q92499	339	372	370	373	Motif	Note=DEAD box
DDX1	Q92499	102	130	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	44	54	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	102	130	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	44	54	1	128	Alternative sequence	ID=VSP_055453;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	102	130	98	113	Alternative sequence	ID=VSP_055454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	102	130	98	113	Alternative sequence	ID=VSP_055454;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DDX1	Q92499	44	54	52	52	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24870230;Dbxref=PMID:24870230
DDX1	Q92499	44	54	52	52	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24870230;Dbxref=PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Inhibits the transcriptional activity of RELA and attenuates NF-kappa-B-mediated gene expression. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Inhibits the transcriptional activity of RELA and attenuates NF-kappa-B-mediated gene expression. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	339	372	371	371	Mutagenesis	Note=Abolishes ability to promote guanylylation of RTCB. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19058135,ECO:0000269|PubMed:24870230;Dbxref=PMID:19058135,PMID:24870230
DDX1	Q92499	102	130	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	110	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	120	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX1	Q92499	102	130	120	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XW3
DDX25	Q9UHL0	400	463	1	483	Chain	ID=PRO_0000030813;Note=ATP-dependent RNA helicase DDX25
DDX25	Q9UHL0	400	463	311	478	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX25	Q9UHL0	400	463	400	402	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	407	414	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	425	432	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	442	448	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	450	452	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX25	Q9UHL0	400	463	453	463	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2RB4
DDX6	P26196	166	215	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	288	331	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	88	123	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	166	215	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	288	331	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	88	123	1	483	Chain	ID=PRO_0000054983;Note=Probable ATP-dependent RNA helicase DDX6
DDX6	P26196	166	215	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	288	331	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	166	215	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	288	331	127	298	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DDX6	P26196	288	331	308	468	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX6	P26196	288	331	308	468	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DDX6	P26196	88	123	96	124	Motif	Note=Q motif
DDX6	P26196	88	123	96	124	Motif	Note=Q motif
DDX6	P26196	288	331	320	320	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-323%3B A-327 and A-331. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	320	320	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-323%3B A-327 and A-331. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	323	323	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-327 and A-331. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	323	323	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-327 and A-331. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	327	327	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-331. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	327	327	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-331. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	331	331	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-327. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	331	331	Mutagenesis	Note=Abolishes interaction with EDC3%3B when associated with A-320%3B A-323 and A-327. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19285948;Dbxref=PMID:19285948
DDX6	P26196	288	331	293	293	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX6	P26196	288	331	293	293	Sequence conflict	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
DDX6	P26196	88	123	98	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	98	100	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	105	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	105	112	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	113	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	113	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	121	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	88	123	121	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	167	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	167	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	174	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	174	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	188	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	188	190	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	191	193	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	196	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	196	199	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	201	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	205	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	166	215	205	211	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	282	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	282	291	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	296	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	296	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1VEC
DDX6	P26196	288	331	309	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	309	315	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	318	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	318	320	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	321	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DDX6	P26196	288	331	321	331	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4CRW
DENR	O43583	98	137	2	198	Chain	ID=PRO_0000130600;Note=Density-regulated protein
DENR	O43583	98	137	115	182	Domain	Note=SUI1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00200
DHPS	P49366	296	338	1	369	Chain	ID=PRO_0000134469;Note=Deoxyhypusine synthase
DHPS	P49366	197	226	1	369	Chain	ID=PRO_0000134469;Note=Deoxyhypusine synthase
DHPS	P49366	296	338	308	309	Nucleotide binding	Note=NAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9493264;Dbxref=PMID:9493264
DHPS	P49366	296	338	314	316	Region	Note=Spermidine binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	323	329	Region	Note=Spermidine binding;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	329	329	Active site	Note=Nucleophile;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9405486;Dbxref=PMID:9405486
DHPS	P49366	296	338	262	308	Alternative sequence	ID=VSP_001351;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8615810;Dbxref=PMID:8615810
DHPS	P49366	296	338	305	305	Mutagenesis	Note=Strongly reduced NAD binding. No effect on enzyme activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	313	313	Mutagenesis	Note=Strongly reduced NAD binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	316	316	Mutagenesis	Note=Reduces spermidine binding by 98%25. Loss of covalent intermediate formation and deoxyhypusine synthesis. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	317	317	Mutagenesis	Note=Strongly reduced NAD binding. No effect on enzyme activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	323	323	Mutagenesis	Note=Reduces spermidine binding by 98%25. Strongly reduced formation of covalent intermediate. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	327	327	Mutagenesis	Note=Reduces spermidine binding by 98%25. Loss of covalent intermediate formation and deoxyhypusine synthesis. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11311149;Dbxref=PMID:11311149
DHPS	P49366	296	338	329	329	Mutagenesis	Note=Loss of covalent intermediate formation and deoxyhypusine synthesis. K->A%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9405486;Dbxref=PMID:9405486
DHPS	P49366	197	226	199	199	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	199	199	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	220	220	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	220	220	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	296	297	Sequence conflict	Note=MR->SG;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	296	338	311	311	Sequence conflict	Note=E->EE;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHPS	P49366	197	226	203	214	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	197	226	220	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	296	298	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	299	307	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	321	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHPS	P49366	296	338	337	341	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1RLZ
DHX29	Q7Z478	1276	1320	1	1369	Chain	ID=PRO_0000245535;Note=ATP-dependent RNA helicase DHX29
DHX29	Q7Z478	1175	1276	1	1369	Chain	ID=PRO_0000245535;Note=ATP-dependent RNA helicase DHX29
DHX33	Q9H6R0	226	283	1	707	Chain	ID=PRO_0000055164;Note=ATP-dependent RNA helicase DHX33
DHX33	Q9H6R0	226	283	84	252	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
DHX33	Q9H6R0	226	283	277	450	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX36	Q9H2U1	735	764	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	406	452	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	644	677	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	201	214	1	1008	Chain	ID=PRO_0000247530;Note=ATP-dependent DNA/RNA helicase DHX36
DHX36	Q9H2U1	644	677	477	647	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
DHX36	Q9H2U1	201	214	106	386	Region	Note=RecA-like domain 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	406	452	387	628	Region	Note=RecA-like domain 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	644	677	629	698	Region	Note=WH domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	644	677	638	697	Region	Note=Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q05B79
DHX36	Q9H2U1	735	764	737	765	Alternative sequence	ID=VSP_020007;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DHX36	Q9H2U1	406	452	416	416	Natural variant	ID=VAR_027141;Note=S->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12198572,ECO:0000269|PubMed:14731398,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs9438,PMID:12198572,PMID:14731398,PMID:15489334
DHX9	Q08211	380	444	1	1270	Chain	ID=PRO_0000055157;Note=ATP-dependent RNA helicase A
DHX9	Q08211	37	84	1	1270	Chain	ID=PRO_0000055157;Note=ATP-dependent RNA helicase A
DHX9	Q08211	1087	1153	1	1270	Chain	ID=PRO_0000055157;Note=ATP-dependent RNA helicase A
DHX9	Q08211	37	84	3	71	Domain	Note=DRBM 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00266,ECO:0000269|PubMed:23361462,ECO:0000269|PubMed:9111062;Dbxref=PMID:23361462,PMID:9111062
DHX9	Q08211	380	444	398	564	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00541,ECO:0000269|PubMed:20510246;Dbxref=PMID:20510246
DHX9	Q08211	380	444	411	419	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:3LLM,ECO:0000269|PubMed:11416126,ECO:0000269|PubMed:20510246;Dbxref=PMID:11416126,PMID:20510246
DHX9	Q08211	37	84	1	250	Region	Note=Interaction with CREBBP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9323138;Dbxref=PMID:9323138
DHX9	Q08211	37	84	53	55	Region	Note=siRNA-binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3VYY,ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	380	444	255	664	Region	Note=Necessary for interaction with RNA polymerase II holoenzyme;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9323138;Dbxref=PMID:9323138
DHX9	Q08211	380	444	313	952	Region	Note=Necessary for interaction with H2AFX;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15613478;Dbxref=PMID:15613478
DHX9	Q08211	380	444	331	380	Region	Note=MTAD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11416126;Dbxref=PMID:11416126
DHX9	Q08211	380	444	398	809	Region	Note=Core helicase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25062910;Dbxref=PMID:25062910
DHX9	Q08211	1087	1153	1150	1270	Region	Note=RGG;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10207077,ECO:0000269|PubMed:25062910,ECO:0000269|PubMed:25149208,ECO:0000269|PubMed:9111062;Dbxref=PMID:10207077,PMID:25062910,PMID:25149208,PMID:9111062
DHX9	Q08211	380	444	418	418	Metal binding	Note=Manganese;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:3LLM,ECO:0000269|PubMed:20510246;Dbxref=PMID:20510246
DHX9	Q08211	380	444	1	1035	Alternative sequence	ID=VSP_042314;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:8690889;Dbxref=PMID:19054851,PMID:8690889
DHX9	Q08211	37	84	1	1035	Alternative sequence	ID=VSP_042314;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:19054851,ECO:0000303|PubMed:8690889;Dbxref=PMID:19054851,PMID:8690889
DHX9	Q08211	37	84	53	53	Mutagenesis	Note=Inhibits siRNA-binding and decreases interaction with AGO2%3B when associated with A-54 and A-55. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	37	84	54	54	Mutagenesis	Note=Inhibits siRNA-binding and decreases interaction with AGO2%3B when associated with A-53 and A-55. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	37	84	55	55	Mutagenesis	Note=Inhibits siRNA-binding and decreases interaction with AGO2%3B when associated with A-53 and A-54. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23361462;Dbxref=PMID:23361462
DHX9	Q08211	380	444	417	417	Mutagenesis	Note=Inhibits interaction with AGO2%2C DICER1 and TARBP2. Abrogates helicase activity and transcriptional activation. Does not inhibit binding to origins of DNA replication. K->R%2CN;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15355351,ECO:0000269|PubMed:17531811,ECO:0000269|PubMed:24990949,ECO:0000269|PubMed:9323138;Dbxref=PMID:15355351,PMID:17531811,PMID:24990949,PMID:9323138
DHX9	Q08211	380	444	417	417	Mutagenesis	Note=Reduces NUP98-induced mRNA transcription and alternative splicing activities. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28221134;Dbxref=PMID:28221134
DHX9	Q08211	1087	1153	1140	1140	Sequence conflict	Note=R->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
DHX9	Q08211	37	84	31	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	37	84	47	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	37	84	54	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	37	84	77	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3VYY
DHX9	Q08211	380	444	376	386	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	389	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	394	403	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	405	410	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	417	431	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	435	437	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DHX9	Q08211	380	444	439	446	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3LLM
DIS3L2	Q8IYB7	439	475	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	475	553	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	641	670	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	317	374	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	763	798	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	439	475	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	475	553	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	641	670	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	317	374	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	763	798	1	885	Chain	ID=PRO_0000314817;Note=DIS3-like exonuclease 2
DIS3L2	Q8IYB7	317	374	201	356	Alternative sequence	ID=VSP_030371;Note=In isoform 5. GREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLP->DNEIEAQRSSWAYPVSHRKSEERMVMHRLQKMRPPAFHKTQELYRRNPCKDQQRWFTSWRKNILEQQPASSNSWLIRTANCLGNTPCFLPQTTECLEFMCLSRTVPRTLWHGLKIMPTHCSSAALWTGRRTAILPWGSWLRVLGRLVKLSLKQKEY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	317	374	201	356	Alternative sequence	ID=VSP_030371;Note=In isoform 5. GREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLP->DNEIEAQRSSWAYPVSHRKSEERMVMHRLQKMRPPAFHKTQELYRRNPCKDQQRWFTSWRKNILEQQPASSNSWLIRTANCLGNTPCFLPQTTECLEFMCLSRTVPRTLWHGLKIMPTHCSSAALWTGRRTAILPWGSWLRVLGRLVKLSLKQKEY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	439	475	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	317	374	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	439	475	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	317	374	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	250	885	Alternative sequence	ID=VSP_030373;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17974005,ECO:0000303|Ref.3;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	439	475	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	317	374	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	439	475	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	641	670	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	317	374	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	763	798	357	885	Alternative sequence	ID=VSP_030374;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
DIS3L2	Q8IYB7	475	553	528	603	Alternative sequence	ID=VSP_030375;Note=In isoform 3. AVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPE->QNADKDGAAHLQASHSPSAEDAEAQPSTEERLPETRGICDRDPDTRLFFLQQQSRVLEAKPQNTIRVEEQTTQLQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	475	553	528	603	Alternative sequence	ID=VSP_030375;Note=In isoform 3. AVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPE->QNADKDGAAHLQASHSPSAEDAEAQPSTEERLPETRGICDRDPDTRLFFLQQQSRVLEAKPQNTIRVEEQTTQLQI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	641	670	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	763	798	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	641	670	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	763	798	604	885	Alternative sequence	ID=VSP_030377;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DIS3L2	Q8IYB7	641	670	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	763	798	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	641	670	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	763	798	620	885	Alternative sequence	ID=VSP_030378;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DIS3L2	Q8IYB7	439	475	443	443	Natural variant	ID=VAR_079527;Note=In PRLMNS%3B unknown pathological significance. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28328139;Dbxref=PMID:28328139
DIS3L2	Q8IYB7	439	475	443	443	Natural variant	ID=VAR_079527;Note=In PRLMNS%3B unknown pathological significance. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28328139;Dbxref=PMID:28328139
DIS3L2	Q8IYB7	475	553	483	483	Natural variant	ID=VAR_067577;Note=Probable disease-associated mutation found in a patient with Wilms tumor%3B does not suppress anchorage-independent cell growth. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs186865544,PMID:22306653
DIS3L2	Q8IYB7	475	553	483	483	Natural variant	ID=VAR_067577;Note=Probable disease-associated mutation found in a patient with Wilms tumor%3B does not suppress anchorage-independent cell growth. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs186865544,PMID:22306653
DIS3L2	Q8IYB7	475	553	489	489	Natural variant	ID=VAR_067578;Note=In PRLMNS. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs387907116,PMID:22306653
DIS3L2	Q8IYB7	475	553	489	489	Natural variant	ID=VAR_067578;Note=In PRLMNS. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22306653;Dbxref=dbSNP:rs387907116,PMID:22306653
DNAJC1	Q96KC8	326	366	48	554	Chain	ID=PRO_0000071042;Note=DnaJ homolog subfamily C member 1
DNAJC1	Q96KC8	326	366	175	554	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250
DNAJC1	Q96KC8	326	366	325	379	Domain	Note=SANT 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624
DNAJC1	Q96KC8	326	366	332	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQQ
DNAJC1	Q96KC8	326	366	352	360	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQQ
DNAJC1	Q96KC8	326	366	364	376	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CQQ
DNAJC24	Q6P3W2	83	106	1	149	Chain	ID=PRO_0000082622;Note=DnaJ homolog subfamily C member 24
DNAJC24	Q6P3W2	83	106	93	148	Zinc finger	Note=DPH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00456
DNAJC24	Q6P3W2	83	106	84	149	Alternative sequence	ID=VSP_056274;Note=In isoform 2. EDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN->GS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
DNAJC24	Q6P3W2	83	106	77	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	92	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	99	101	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	102	105	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC24	Q6P3W2	83	106	106	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L6L
DNAJC3	Q13217	243	282	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
DNAJC3	Q13217	131	182	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
DNAJC3	Q13217	106	131	32	504	Chain	ID=PRO_0000071045;Note=DnaJ homolog subfamily C member 3
DNAJC3	Q13217	131	182	105	138	Repeat	Note=TPR 3
DNAJC3	Q13217	106	131	105	138	Repeat	Note=TPR 3
DNAJC3	Q13217	131	182	154	187	Repeat	Note=TPR 4
DNAJC3	Q13217	243	282	222	255	Repeat	Note=TPR 6
DNAJC3	Q13217	243	282	268	301	Repeat	Note=TPR 7
DNAJC3	Q13217	243	282	274	274	Modified residue	Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039
DNAJC3	Q13217	243	282	248	258	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21799829;Dbxref=PMID:21799829
DNAJC3	Q13217	106	131	105	117	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	131	182	121	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	106	131	121	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	131	182	138	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	131	182	170	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	243	282	238	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DNAJC3	Q13217	243	282	256	281	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Y4T
DPH1	Q9BZG8	232	254	1	443	Chain	ID=PRO_0000307882;Note=2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
DPH1	Q9BZG8	232	254	234	234	Natural variant	ID=VAR_076413;Note=In DEDSSH. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25558065;Dbxref=dbSNP:rs730882250,PMID:25558065
DPH2	Q9BQC3	161	389	1	489	Chain	ID=PRO_0000307889;Note=2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
DPH2	Q9BQC3	161	389	27	161	Alternative sequence	ID=VSP_056053;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
DPH2	Q9BQC3	161	389	162	389	Alternative sequence	ID=VSP_047151;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
DPH2	Q9BQC3	161	389	266	266	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
DPH7	Q9BTV6	237	258	1	452	Chain	ID=PRO_0000050906;Note=Diphthine methyltransferase
DPH7	Q9BTV6	237	258	230	273	Repeat	Note=WD 4
DRG2	P55039	318	336	1	364	Chain	ID=PRO_0000205427;Note=Developmentally-regulated GTP-binding protein 2
DRG2	P55039	75	105	1	364	Chain	ID=PRO_0000205427;Note=Developmentally-regulated GTP-binding protein 2
DRG2	P55039	75	105	63	288	Domain	Note=OBG-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
DRG2	P55039	75	105	69	76	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01047
EARS2	Q5JPH6	46	98	42	523	Chain	ID=PRO_0000254560;Note=Probable glutamate--tRNA ligase%2C mitochondrial
EARS2	Q5JPH6	46	98	45	53	Motif	Note="HIGH" region
EARS2	Q5JPH6	46	98	50	50	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EARS2	Q5JPH6	46	98	76	76	Binding site	Note=Glutamate;Ontology_term=ECO:0000250;evidence=ECO:0000250
EARS2	Q5JPH6	46	98	55	55	Natural variant	ID=VAR_069235;Note=In COXPD12. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22492562;Dbxref=dbSNP:rs770862902,PMID:22492562
EARS2	Q5JPH6	46	98	65	65	Natural variant	ID=VAR_069236;Note=In COXPD12. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23008233;Dbxref=dbSNP:rs397514595,PMID:23008233
EARS2	Q5JPH6	46	98	96	96	Natural variant	ID=VAR_069237;Note=In COXPD12. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22492562;Dbxref=dbSNP:rs397514593,PMID:22492562
EEF1A1	P68104	48	108	2	462	Chain	ID=PRO_0000090885;Note=Elongation factor 1-alpha 1
EEF1A1	P68104	48	108	2	462	Chain	ID=PRO_0000090885;Note=Elongation factor 1-alpha 1
EEF1A1	P68104	48	108	5	242	Domain	Note=tr-type G
EEF1A1	P68104	48	108	5	242	Domain	Note=tr-type G
EEF1A1	P68104	48	108	91	95	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	91	95	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	70	74	Region	Note=G2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	70	74	Region	Note=G2;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	91	94	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	91	94	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF1A1	P68104	48	108	55	55	Modified residue	Note=N6%2CN6-dimethyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7
EEF1A1	P68104	48	108	55	55	Modified residue	Note=N6%2CN6-dimethyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7
EEF1A1	P68104	48	108	79	79	Modified residue	Note=N6%2CN6%2CN6-trimethyllysine%3B by EEF1AKMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26545399;Dbxref=PMID:26545399
EEF1A1	P68104	48	108	79	79	Modified residue	Note=N6%2CN6%2CN6-trimethyllysine%3B by EEF1AKMT1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26545399;Dbxref=PMID:26545399
EEF1A1	P68104	48	108	55	55	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	55	55	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	79	79	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	79	79	Mutagenesis	Note=No effect on methylation by EEF1AKMT2. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25144183;Dbxref=PMID:25144183
EEF1A1	P68104	48	108	83	83	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1A1	P68104	48	108	83	83	Sequence conflict	Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	2	281	Chain	ID=PRO_0000155046;Note=Elongation factor 1-delta
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	44	44	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	60	60	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	40	63	Alternative sequence	ID=VSP_043812;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF1D	P29692	39	63	44	44	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
EEF2	P13639	689	750	2	858	Chain	ID=PRO_0000091000;Note=Elongation factor 2
EEF2	P13639	571	689	2	858	Chain	ID=PRO_0000091000;Note=Elongation factor 2
EEF2	P13639	299	337	2	858	Chain	ID=PRO_0000091000;Note=Elongation factor 2
EEF2	P13639	299	337	17	362	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EEF2	P13639	571	689	586	587	Site	Note=Cleavage;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24648518;Dbxref=PMID:24648518
EEF2	P13639	571	689	605	606	Site	Note=Cleavage;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24648518;Dbxref=PMID:24648518
EEF2	P13639	299	337	325	325	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05197
EEF2	P13639	571	689	572	572	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58252
EEF2	P13639	571	689	595	595	Modified residue	Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:23184662;Dbxref=PMID:23186163,PMID:23184662
EEF2	P13639	571	689	619	619	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58252
EEF2	P13639	689	750	715	715	Modified residue	Note=Diphthamide;Ontology_term=ECO:0000250;evidence=ECO:0000250
EEF2	P13639	299	337	322	322	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24648518;Dbxref=PMID:24648518
EEF2	P13639	571	689	596	596	Natural variant	ID=VAR_070792;Note=In SCA26%3B compromises the mechanics of translocation. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001565;Dbxref=dbSNP:rs587777052,PMID:23001565
EEF2	P13639	571	689	595	595	Mutagenesis	Note=Strongly reduced phosphorylation at Thr-57. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23184662;Dbxref=PMID:23184662
EEF2	P13639	571	689	599	599	Mutagenesis	Note=Strongly reduced phosphorylation at Thr-57. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23184662;Dbxref=PMID:23184662
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	1	165	Chain	ID=PRO_0000314151;Note=Probable RNA-binding protein EIF1AD
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AD	Q8N9N8	102	117	104	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DGY
EIF1AX	P47813	68	85	1	144	Chain	ID=PRO_0000145101;Note=Eukaryotic translation initiation factor 1A%2C X-chromosomal
EIF1AX	P47813	68	85	22	96	Domain	Note=S1-like
EIF1AX	P47813	68	85	76	80	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D7Q
EIF1AX	P47813	68	85	82	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1D7Q
EIF1AY	O14602	117	134	1	144	Chain	ID=PRO_0000145102;Note=Eukaryotic translation initiation factor 1A%2C Y-chromosomal
EIF2AK2	P19525	241	261	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	262	302	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	416	459	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	493	511	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	303	355	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	241	261	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	262	302	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	416	459	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	493	511	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	303	355	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
EIF2AK2	P19525	262	302	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	416	459	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	493	511	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	303	355	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	262	302	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	416	459	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	493	511	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	303	355	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	303	355	331	343	Repeat	Note=1
EIF2AK2	P19525	303	355	331	343	Repeat	Note=1
EIF2AK2	P19525	303	355	345	357	Repeat	Note=2
EIF2AK2	P19525	303	355	345	357	Repeat	Note=2
EIF2AK2	P19525	262	302	273	281	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	262	302	273	281	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK2	P19525	262	302	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	416	459	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	493	511	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	303	355	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	262	302	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	416	459	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	493	511	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	303	355	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121867;Dbxref=PMID:15121867
EIF2AK2	P19525	303	355	331	357	Region	Note=2 X 13 AA approximate repeats
EIF2AK2	P19525	303	355	331	357	Region	Note=2 X 13 AA approximate repeats
EIF2AK2	P19525	262	302	296	296	Binding site	Note=ATP
EIF2AK2	P19525	262	302	296	296	Binding site	Note=ATP
EIF2AK2	P19525	241	261	242	242	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	242	242	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	255	255	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	255	255	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	262	302	293	293	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
EIF2AK2	P19525	262	302	293	293	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16373505;Dbxref=PMID:16373505
EIF2AK2	P19525	416	459	446	446	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
EIF2AK2	P19525	416	459	446	446	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
EIF2AK2	P19525	416	459	451	451	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
EIF2AK2	P19525	416	459	451	451	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11337501,ECO:0000269|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
EIF2AK2	P19525	416	459	456	456	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
EIF2AK2	P19525	416	459	456	456	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
EIF2AK2	P19525	262	302	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	303	355	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	262	302	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	303	355	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7
EIF2AK2	P19525	416	459	428	428	Natural variant	ID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
EIF2AK2	P19525	416	459	428	428	Natural variant	ID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
EIF2AK2	P19525	416	459	439	439	Natural variant	ID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EIF2AK2	P19525	416	459	439	439	Natural variant	ID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
EIF2AK2	P19525	493	511	506	506	Natural variant	ID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
EIF2AK2	P19525	493	511	506	506	Natural variant	ID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
EIF2AK2	P19525	241	261	242	242	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	242	242	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	262	302	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	241	261	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	262	302	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	241	261	255	255	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	255	255	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Mutagenesis	Note=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	241	261	258	258	Mutagenesis	Note=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	262	302	296	296	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	262	302	296	296	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11152499;Dbxref=PMID:11152499
EIF2AK2	P19525	416	459	446	446	Mutagenesis	Note=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	416	459	446	446	Mutagenesis	Note=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	416	459	451	451	Mutagenesis	Note=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	416	459	451	451	Mutagenesis	Note=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11337501;Dbxref=PMID:11337501
EIF2AK2	P19525	241	261	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	241	261	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	267	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	267	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	276	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	276	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	292	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	262	302	292	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	303	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	303	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	306	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	306	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	323	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	303	355	323	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	417	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	417	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	420	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	420	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	427	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	427	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	457	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	416	459	457	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	488	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	488	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	505	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
EIF2AK2	P19525	493	511	505	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UIU
EIF2AK2	P19525	493	511	509	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK2	P19525	493	511	509	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A19
EIF2AK3	Q9NZJ5	995	1029	30	1116	Chain	ID=PRO_0000024322;Note=Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3	Q9NZJ5	939	995	30	1116	Chain	ID=PRO_0000024322;Note=Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3	Q9NZJ5	146	211	30	1116	Chain	ID=PRO_0000024322;Note=Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3	Q9NZJ5	146	211	30	514	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF2AK3	Q9NZJ5	995	1029	536	1116	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF2AK3	Q9NZJ5	939	995	536	1116	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF2AK3	Q9NZJ5	995	1029	593	1077	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK3	Q9NZJ5	939	995	593	1077	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
EIF2AK3	Q9NZJ5	939	995	982	982	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z2B5
EIF2AK3	Q9NZJ5	146	211	166	166	Natural variant	ID=VAR_011410;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10026192,ECO:0000269|PubMed:10677345,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs13045,PMID:10026192,PMID:10677345,PMID:15489334
EIF2AK3	Q9NZJ5	146	211	152	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	161	164	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	166	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	171	173	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	178	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	193	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	146	211	207	209	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YZS
EIF2AK3	Q9NZJ5	939	995	940	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	939	995	943	945	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	939	995	951	953	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	995	1029	993	996	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	939	995	993	996	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	995	1029	1004	1018	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2AK3	Q9NZJ5	995	1029	1024	1035	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4X7K
EIF2B1	Q14232	161	183	1	305	Chain	ID=PRO_0000156055;Note=Translation initiation factor eIF-2B subunit alpha
EIF2B1	Q14232	161	183	162	222	Alternative sequence	ID=VSP_055469;Note=In isoform 2. KKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQ->QVPFCSVMCPAIILQSKLRITVQQDQNQNVPPACQQSALPFIVPFPAFGRKITEFAAGRSI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EIF2B1	Q14232	161	183	183	183	Natural variant	ID=VAR_068450;Note=In VWM. V->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15776425;Dbxref=dbSNP:rs863225048,PMID:15776425
EIF2B1	Q14232	161	183	160	169	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	170	172	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	175	178	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	180	182	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B1	Q14232	161	183	183	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ECS
EIF2B3	Q9NR50	325	351	1	452	Chain	ID=PRO_0000156079;Note=Translation initiation factor eIF-2B subunit gamma
EIF2B3	Q9NR50	189	218	1	452	Chain	ID=PRO_0000156079;Note=Translation initiation factor eIF-2B subunit gamma
EIF2B3	Q9NR50	325	351	346	346	Natural variant	ID=VAR_068472;Note=In VWM. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19158808;Dbxref=dbSNP:rs119474039,PMID:19158808
EIF2B3	Q9NR50	189	218	185	189	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B3	Q9NR50	189	218	191	198	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B3	Q9NR50	189	218	209	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	255	281	2	721	Chain	ID=PRO_0000156073;Note=Translation initiation factor eIF-2B subunit epsilon
EIF2B5	Q13144	228	255	2	721	Chain	ID=PRO_0000156073;Note=Translation initiation factor eIF-2B subunit epsilon
EIF2B5	Q13144	255	281	269	269	Natural variant	ID=VAR_068461;Note=In VWM. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15776425;Dbxref=dbSNP:rs113994058,PMID:15776425
EIF2B5	Q13144	255	281	269	269	Natural variant	ID=VAR_068462;Note=In VWM. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19158808;Dbxref=dbSNP:rs113994057,PMID:19158808
EIF2B5	Q13144	255	281	270	270	Natural variant	ID=VAR_068463;Note=In VWM. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21484434;Dbxref=dbSNP:rs397514646,PMID:21484434
EIF2B5	Q13144	228	255	229	233	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	228	255	238	241	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	228	255	244	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	255	281	254	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	228	255	254	262	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2B5	Q13144	255	281	269	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6CAJ
EIF2S2	P20042	228	246	2	333	Chain	ID=PRO_0000137406;Note=Eukaryotic translation initiation factor 2 subunit 2
EIF2S3	P41091	159	212	2	472	Chain	ID=PRO_0000137438;Note=Eukaryotic translation initiation factor 2 subunit 3
EIF2S3	P41091	212	257	2	472	Chain	ID=PRO_0000137438;Note=Eukaryotic translation initiation factor 2 subunit 3
EIF2S3	P41091	159	212	39	248	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	212	257	39	248	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	159	212	190	193	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF2S3	P41091	159	212	190	193	Region	Note=G4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	212	257	225	227	Region	Note=G5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF2S3	P41091	212	257	222	222	Natural variant	ID=VAR_077139;Note=In MEHMO%3B decreased interaction with the other eIF2 complex subunits EIF2S1 and EIF2S2. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23063529;Dbxref=dbSNP:rs886040855,PMID:23063529
EIF3A	Q14152	481	543	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	374	409	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	447	509	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	340	375	2	1382	Chain	ID=PRO_0000123537;Note=Eukaryotic translation initiation factor 3 subunit A
EIF3A	Q14152	481	543	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	374	409	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	447	509	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	340	375	315	498	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3A	Q14152	481	543	492	492	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
EIF3A	Q14152	447	509	492	492	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163
EIF3A	Q14152	374	409	386	386	Natural variant	ID=VAR_024438;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs967185,PMID:14702039
EIF3A	Q14152	481	543	520	520	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF3A	Q14152	340	375	336	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	340	375	346	348	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	340	375	354	358	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	367	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	340	375	367	375	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	377	381	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	385	395	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	374	409	400	416	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	448	451	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	452	458	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	464	476	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	481	543	483	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	483	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	481	543	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	486	489	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	481	543	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3A	Q14152	447	509	490	492	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3B	P55884	386	429	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	718	744	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	386	429	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	718	744	1	814	Chain	ID=PRO_0000123531;Note=Eukaryotic translation initiation factor 3 subunit B
EIF3B	P55884	386	429	366	425	Repeat	Note=WD 3
EIF3B	P55884	386	429	366	425	Repeat	Note=WD 3
EIF3B	P55884	386	429	426	489	Repeat	Note=WD 4
EIF3B	P55884	386	429	426	489	Repeat	Note=WD 4
EIF3B	P55884	386	429	124	413	Region	Note=Sufficient for interaction with EIF3E
EIF3B	P55884	386	429	124	413	Region	Note=Sufficient for interaction with EIF3E
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	1	913	Chain	ID=PRO_0000123525;Note=Eukaryotic translation initiation factor 3 subunit C
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	395	414	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	422	424	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3C	Q99613	394	436	426	428	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3CL	B5ME19	119	161	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
EIF3CL	B5ME19	395	437	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
EIF3CL	B5ME19	119	161	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
EIF3CL	B5ME19	395	437	1	914	Chain	ID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
EIF3E	P60228	122	157	2	445	Chain	ID=PRO_0000123515;Note=Eukaryotic translation initiation factor 3 subunit E
EIF3E	P60228	388	433	2	445	Chain	ID=PRO_0000123515;Note=Eukaryotic translation initiation factor 3 subunit E
EIF3E	P60228	283	317	2	445	Chain	ID=PRO_0000123515;Note=Eukaryotic translation initiation factor 3 subunit E
EIF3E	P60228	388	433	221	398	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3E	P60228	283	317	221	398	Domain	Note=PCI;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01185
EIF3E	P60228	122	157	4	128	Region	Note=Sufficient for interaction with EPAS1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17324924;Dbxref=PMID:17324924
EIF3E	P60228	122	157	9	195	Region	Note=Sufficient for interaction with TRIM27;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10504338;Dbxref=PMID:10504338
EIF3E	P60228	388	433	351	445	Region	Note=Sufficient for interaction with MCM7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17310990;Dbxref=PMID:17310990
EIF3E	P60228	388	433	399	399	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
EIF3E	P60228	283	317	312	312	Mutagenesis	Note=Promotes nuclear accumulation. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17761670;Dbxref=PMID:17761670
EIF3E	P60228	122	157	124	140	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	122	157	144	152	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	283	317	281	289	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	283	317	291	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	283	317	305	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	388	433	386	389	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3E	P60228	388	433	390	392	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3G	O75821	100	135	2	320	Chain	ID=PRO_0000123510;Note=Eukaryotic translation initiation factor 3 subunit G
EIF3H	O15372	186	235	1	352	Chain	ID=PRO_0000213961;Note=Eukaryotic translation initiation factor 3 subunit H
EIF3H	O15372	96	152	1	352	Chain	ID=PRO_0000213961;Note=Eukaryotic translation initiation factor 3 subunit H
EIF3H	O15372	96	152	39	173	Domain	Note=MPN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01182
EIF3H	O15372	96	152	97	109	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	96	152	115	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	96	152	132	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	96	152	148	152	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	197	200	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	203	206	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	209	215	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3H	O15372	186	235	216	219	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3J8B
EIF3I	Q13347	213	243	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
EIF3I	Q13347	1	32	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
EIF3I	Q13347	83	133	1	325	Chain	ID=PRO_0000051036;Note=Eukaryotic translation initiation factor 3 subunit I
EIF3I	Q13347	1	32	1	39	Repeat	Note=WD 1
EIF3I	Q13347	83	133	87	127	Repeat	Note=WD 3
EIF3I	Q13347	213	243	180	217	Repeat	Note=WD 5
EIF3I	Q13347	213	243	221	267	Repeat	Note=WD 6
EIF3I	Q13347	213	243	219	219	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EIF3J	O75822	136	190	2	258	Chain	ID=PRO_0000123506;Note=Eukaryotic translation initiation factor 3 subunit J
EIF3J	O75822	136	190	137	191	Alternative sequence	ID=VSP_054593;Note=In isoform 2. GVNNAVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISL->V;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EIF3J	O75822	136	190	141	141	Natural variant	ID=VAR_034007;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2303578,PMID:14702039
EIF3J	O75822	136	190	145	147	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
EIF3J	O75822	136	190	153	167	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
EIF3J	O75822	136	190	168	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
EIF3J	O75822	136	190	176	188	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BPJ
EIF4A1	P60842	208	256	2	406	Chain	ID=PRO_0000054933;Note=Eukaryotic initiation factor 4A-I
EIF4A1	P60842	256	302	2	406	Chain	ID=PRO_0000054933;Note=Eukaryotic initiation factor 4A-I
EIF4A1	P60842	208	256	63	234	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A1	P60842	208	256	245	406	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A1	P60842	256	302	245	406	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A1	P60842	208	256	238	238	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P60843
EIF4A1	P60842	208	256	225	225	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EIF4A1	P60842	208	256	238	238	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
EIF4A1	P60842	208	256	208	214	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9N
EIF4A1	P60842	208	256	218	224	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9N
EIF4A1	P60842	208	256	225	227	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EIQ
EIF4A1	P60842	208	256	232	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G9N
EIF4A1	P60842	208	256	241	243	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	208	256	246	251	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	208	256	256	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	256	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	273	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	282	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	291	296	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2ZU6
EIF4A1	P60842	256	302	300	302	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EIQ
EIF4A2	Q14240	303	333	1	407	Chain	ID=PRO_0000054938;Note=Eukaryotic initiation factor 4A-II
EIF4A2	Q14240	209	257	1	407	Chain	ID=PRO_0000054938;Note=Eukaryotic initiation factor 4A-II
EIF4A2	Q14240	209	257	64	235	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A2	Q14240	303	333	246	407	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A2	Q14240	209	257	246	407	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A2	Q14240	209	257	212	213	Sequence conflict	Note=LL->FA;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4A2	Q14240	209	257	209	213	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BOR
EIF4A2	Q14240	209	257	219	228	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BOR
EIF4A2	Q14240	209	257	233	235	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BOR
EIF4A3	P38919	168	195	1	411	Chain	ID=PRO_0000423267;Note=Eukaryotic initiation factor 4A-III
EIF4A3	P38919	328	363	1	411	Chain	ID=PRO_0000423267;Note=Eukaryotic initiation factor 4A-III
EIF4A3	P38919	103	124	1	411	Chain	ID=PRO_0000423267;Note=Eukaryotic initiation factor 4A-III
EIF4A3	P38919	168	195	2	411	Chain	ID=PRO_0000054942;Note=Eukaryotic initiation factor 4A-III%2C N-terminally processed
EIF4A3	P38919	328	363	2	411	Chain	ID=PRO_0000054942;Note=Eukaryotic initiation factor 4A-III%2C N-terminally processed
EIF4A3	P38919	103	124	2	411	Chain	ID=PRO_0000054942;Note=Eukaryotic initiation factor 4A-III%2C N-terminally processed
EIF4A3	P38919	168	195	69	239	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A3	P38919	103	124	69	239	Domain	Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541
EIF4A3	P38919	328	363	250	411	Domain	Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542
EIF4A3	P38919	168	195	187	190	Motif	Note=DEAD box;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4A3	P38919	328	363	342	342	Binding site	Note=ATP;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PDB:2HYI,ECO:0000244|PDB:2J0Q,ECO:0000244|PDB:2J0S,ECO:0000244|PDB:2XB2,ECO:0000244|PDB:3EX7,ECO:0000269|PubMed:16923391,ECO:0000269|PubMed:16931718,ECO:0000269|PubMed:19033377;Dbxref=PMID:16923391,PMID:16931718,PMID:19033377
EIF4A3	P38919	103	124	124	124	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P60842
EIF4A3	P38919	328	363	334	334	Mutagenesis	Note=Reduced incorporation into EJCs. T->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23236153;Dbxref=PMID:23236153
EIF4A3	P38919	103	124	102	104	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0U
EIF4A3	P38919	103	124	109	112	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	103	124	116	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	168	195	164	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	168	195	183	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	168	195	189	195	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	335	337	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0S
EIF4A3	P38919	328	363	338	340	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J0S
EIF4A3	P38919	328	363	346	353	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	356	358	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4A3	P38919	328	363	360	365	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4C9B
EIF4B	P23588	177	222	1	611	Chain	ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B
EIF4B	P23588	120	159	1	611	Chain	ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B
EIF4B	P23588	222	268	1	611	Chain	ID=PRO_0000081616;Note=Eukaryotic translation initiation factor 4B
EIF4B	P23588	120	159	96	173	Domain	Note=RRM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
EIF4B	P23588	177	222	164	331	Compositional bias	Note=Arg-rich
EIF4B	P23588	222	268	164	331	Compositional bias	Note=Arg-rich
EIF4B	P23588	177	222	169	325	Compositional bias	Note=Asp-rich
EIF4B	P23588	222	268	169	325	Compositional bias	Note=Asp-rich
EIF4B	P23588	177	222	192	192	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EIF4B	P23588	177	222	207	207	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EIF4B	P23588	177	222	219	219	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
EIF4B	P23588	120	159	121	159	Alternative sequence	ID=VSP_057351;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
EIF4B	P23588	177	222	203	203	Natural variant	ID=VAR_064710;Note=Found in a renal cell carcinoma case%3B somatic mutation. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752
EIF4B	P23588	222	268	246	246	Sequence conflict	Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4B	P23588	120	159	121	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
EIF4B	P23588	120	159	130	133	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2J76
EIF4B	P23588	120	159	140	146	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
EIF4B	P23588	120	159	147	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
EIF4B	P23588	120	159	155	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WI8
EIF4E	P06730	42	73	2	217	Chain	ID=PRO_0000193634;Note=Eukaryotic translation initiation factor 4E
EIF4E	P06730	95	133	2	217	Chain	ID=PRO_0000193634;Note=Eukaryotic translation initiation factor 4E
EIF4E	P06730	42	73	56	57	Region	Note=7-methylguanosine-containing mRNA cap binding
EIF4E	P06730	42	73	73	77	Region	Note=EIF4EBP1/2/3 binding
EIF4E	P06730	95	133	102	103	Region	Note=7-methylguanosine-containing mRNA cap binding
EIF4E	P06730	95	133	132	139	Region	Note=EIF4EBP1/2/3 binding
EIF4E	P06730	95	133	133	133	Alternative sequence	ID=VSP_042014;Note=In isoform 2. T->TRWDLAMLPRLVSNFWPQVILPLQPPKVLELQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16341674;Dbxref=PMID:16341674
EIF4E	P06730	42	73	53	53	Mutagenesis	Note=No effect on phosphorylation level nor incorporation into eIF4F complex. S->A%2CD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7590282,ECO:0000269|PubMed:8505316;Dbxref=PMID:7590282,PMID:8505316
EIF4E	P06730	42	73	73	73	Mutagenesis	Note=Abolishes binding to EIF4EBP1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22578813;Dbxref=PMID:22578813
EIF4E	P06730	95	133	102	102	Mutagenesis	Note=Decrease in mRNA cap binding%3B when associated with A-105. W->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	103	103	Mutagenesis	Note=No effect. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	104	104	Mutagenesis	Note=No effect. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	105	105	Mutagenesis	Note=Decrease in mRNA cap binding%3B when associated with L-102. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1672854;Dbxref=PMID:1672854
EIF4E	P06730	95	133	119	119	Mutagenesis	Note=Higher affinity for EIF4G1. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17036047;Dbxref=PMID:17036047
EIF4E	P06730	95	133	127	127	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4E	P06730	42	73	38	49	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	42	73	51	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5GW6
EIF4E	P06730	42	73	56	59	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	42	73	60	68	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	42	73	69	82	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	89	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	100	103	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2GPQ
EIF4E	P06730	95	133	105	109	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	111	116	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	119	122	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	123	125	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E	P06730	95	133	126	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4TPW
EIF4E2	O60573	90	125	1	245	Chain	ID=PRO_0000193664;Note=Eukaryotic translation initiation factor 4E type 2
EIF4E2	O60573	45	90	1	245	Chain	ID=PRO_0000193664;Note=Eukaryotic translation initiation factor 4E type 2
EIF4E2	O60573	45	90	54	57	Region	Note=EIF4EBP1/2/3 binding
EIF4E2	O60573	45	90	78	79	Region	Note=7-methylguanosine-containing mRNA cap binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4E2	O60573	90	125	95	99	Region	Note=EIF4EBP1/2/3 binding
EIF4E2	O60573	90	125	124	125	Region	Note=7-methylguanosine-containing mRNA cap binding
EIF4E2	O60573	90	125	110	110	Binding site	Note=7-methylguanosine-containing mRNA cap
EIF4E2	O60573	45	90	63	63	Mutagenesis	Note=Unable to bind capped mRNA. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	95	95	Mutagenesis	Note=Ability to bind capped mRNA reduced to 40%25 of wild-type. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	121	121	Mutagenesis	Note=Does not affect ubiquitination by ARIH1%3B when associated with R-130%3B R-134 and R-222. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25624349;Dbxref=PMID:25624349
EIF4E2	O60573	90	125	124	126	Mutagenesis	Note=Unable to bind capped mRNA. WED->FAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	124	124	Mutagenesis	Note=Ability to bind capped mRNA reduced to less than 10%25 of wild-type. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	124	124	Mutagenesis	Note=Ability to bind capped mRNA reduced to 13%25 of wild-type. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	90	125	125	125	Mutagenesis	Note=Ability to bind capped mRNA reduced to less than 10%25 of wild-type. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582349;Dbxref=PMID:9582349
EIF4E2	O60573	45	90	55	67	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	45	90	75	81	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	82	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	45	90	82	90	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	91	98	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	104	106	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E2	O60573	90	125	109	117	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2JGB
EIF4E3	Q8N5X7	157	209	1	224	Chain	ID=PRO_0000287697;Note=Eukaryotic translation initiation factor 4E type 3
EIF4E3	Q8N5X7	157	209	169	174	Region	Note=7-methylguanosine-containing mRNA cap binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4ENIF1	Q9NRA8	504	528	1	985	Chain	ID=PRO_0000064381;Note=Eukaryotic translation initiation factor 4E transporter
EIF4ENIF1	Q9NRA8	504	528	1	985	Chain	ID=PRO_0000064381;Note=Eukaryotic translation initiation factor 4E transporter
EIF4ENIF1	Q9NRA8	504	528	513	513	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EIF4ENIF1	Q9NRA8	504	528	513	513	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
EIF4ENIF1	Q9NRA8	504	528	493	504	Alternative sequence	ID=VSP_003784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4ENIF1	Q9NRA8	504	528	493	504	Alternative sequence	ID=VSP_003784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	10	70	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	218	498	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	946	981	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	695	752	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	1400	1449	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	1367	1400	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	1476	1525	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
EIF4G3	O43432	695	752	745	783	Repeat	Note=HEAT 1
EIF4G3	O43432	946	981	755	983	Domain	Note=MIF4G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00698
EIF4G3	O43432	946	981	945	984	Repeat	Note=HEAT 5
EIF4G3	O43432	1400	1449	1416	1585	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF4G3	O43432	1476	1525	1416	1585	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF4G3	O43432	946	981	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	695	752	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	1400	1449	1433	1585	Region	Note=EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	1476	1525	1433	1585	Region	Note=EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
EIF4G3	O43432	218	498	447	475	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
EIF4G3	O43432	695	752	699	700	Site	Note=Cleavage%3B by enterovirus/rhinovirus protease 2A
EIF4G3	O43432	695	752	700	701	Site	Note=Cleavage%3B by foot-and-mouth disease virus leader protease
EIF4G3	O43432	218	498	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
EIF4G3	O43432	218	498	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EIF4G3	O43432	218	498	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
EIF4G3	O43432	218	498	441	441	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80XI3
EIF4G3	O43432	218	498	495	495	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17693683,ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:16964243,PMID:17693683,PMID:18088087,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EIF4G3	O43432	1400	1449	1409	1409	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
EIF4G3	O43432	10	70	10	10	Alternative sequence	ID=VSP_043447;Note=In isoform 3. P->PGGFRPIQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	10	70	11	11	Alternative sequence	ID=VSP_010487;Note=In isoform 2. F->FAAGPRPPHHQF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	218	498	219	498	Alternative sequence	ID=VSP_054502;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	946	981	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	695	752	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	1400	1449	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	1367	1400	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	1476	1525	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
EIF4G3	O43432	218	498	378	378	Natural variant	ID=VAR_048924;Note=Q->R;Dbxref=dbSNP:rs35731992
EIF4G3	O43432	218	498	496	496	Natural variant	ID=VAR_034009;Note=P->A;Dbxref=dbSNP:rs35176330
EIF4G3	O43432	218	498	333	333	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF4G3	O43432	695	752	746	762	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HU3
EIF4G3	O43432	946	981	946	961	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HU3
EIF4G3	O43432	946	981	967	981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HU3
EIF4H	Q15056	136	156	2	248	Chain	ID=PRO_0000081619;Note=Eukaryotic translation initiation factor 4H
EIF4H	Q15056	136	156	137	157	Region	Note=HHV-1 Vhs binding site
EIF4H	Q15056	136	156	136	136	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUK2
EIF4H	Q15056	136	156	137	156	Alternative sequence	ID=VSP_005799;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7584026;Dbxref=PMID:14702039,PMID:15489334,PMID:7584026
EIF5	P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
EIF5	P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
EIF5	P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
EIF5	P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF5	P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF5	P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00695
EIF5	P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5	P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5	P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5	P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5	P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2IU1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	90	134	2	154	Chain	ID=PRO_0000142451;Note=Eukaryotic translation initiation factor 5A-1
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	55	90	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	20	90	Region	Note=DOHH-binding
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	90	134	121	121	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63242
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	55	55	Mutagenesis	Note=Causes total inactivation of eIF5A in supporting yeast growth. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18067580;Dbxref=PMID:18067580
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	81	81	Mutagenesis	Note=Leads to temperature sensitivity when expressed in yeast cells. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16987817;Dbxref=PMID:16987817
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	85	85	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	90	134	109	109	Sequence conflict	Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	55	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	63	65	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	68	74	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	77	82	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	55	90	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	85	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	98	102	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	117	129	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A	P63241	90	134	134	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CPF
EIF5A2	Q9GZV4	55	90	2	153	Chain	ID=PRO_0000229764;Note=Eukaryotic translation initiation factor 5A-2
EIF5A2	Q9GZV4	90	134	2	153	Chain	ID=PRO_0000229764;Note=Eukaryotic translation initiation factor 5A-2
EIF5B	O60841	492	517	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	462	492	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	757	801	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	862	916	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	801	862	1	1220	Chain	ID=PRO_0000137294;Note=Eukaryotic translation initiation factor 5B
EIF5B	O60841	757	801	629	846	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	801	862	629	846	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	757	801	756	759	Region	Note=G4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	801	862	824	826	Region	Note=G5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
EIF5B	O60841	492	517	491	496	Compositional bias	Note=Poly-Glu
EIF5B	O60841	462	492	491	496	Compositional bias	Note=Poly-Glu
EIF5B	O60841	492	517	498	498	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
EIF5B	O60841	757	801	759	759	Mutagenesis	Note=Loss of activity%3B both in vivo and in vitro. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10200264;Dbxref=PMID:10200264
EIF5B	O60841	862	916	894	894	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
ELAVL4	P26378	245	257	1	380	Chain	ID=PRO_0000081583;Note=ELAV-like protein 4
ERBB2	P04626	908	957	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	736	769	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	633	648	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	146	191	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	769	831	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	831	883	23	1255	Chain	ID=PRO_0000016669;Note=Receptor tyrosine-protein kinase erbB-2
ERBB2	P04626	633	648	23	652	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	146	191	23	652	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	908	957	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	736	769	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	769	831	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	831	883	676	1255	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
ERBB2	P04626	908	957	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	736	769	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	769	831	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	831	883	720	987	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	831	883	845	845	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028
ERBB2	P04626	736	769	753	753	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ERBB2	P04626	146	191	182	182	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ERBB2	P04626	146	191	187	187	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000255;evidence=ECO:0000244|PDB:1N8Z,ECO:0000244|PDB:1S78,ECO:0000244|PDB:2A91,ECO:0000244|PDB:3N85,ECO:0000255
ERBB2	P04626	146	191	162	192	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PDB:1N8Z,ECO:0000244|PDB:1S78,ECO:0000244|PDB:2A91,ECO:0000244|PDB:3BE1,ECO:0000244|PDB:3H3B,ECO:0000244|PDB:3MZW,ECO:0000244|PDB:3N85,ECO:0000244|PDB:3WLW,ECO:0000244|PDB:3WSQ,ECO:0000244|PDB:4HRL,ECO:0000244|PDB:4HRM
ERBB2	P04626	633	648	626	634	Disulfide bond	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N85
ERBB2	P04626	633	648	630	642	Disulfide bond	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N85
ERBB2	P04626	633	648	1	686	Alternative sequence	ID=VSP_039250;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERBB2	P04626	146	191	1	686	Alternative sequence	ID=VSP_039250;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERBB2	P04626	146	191	1	610	Alternative sequence	ID=VSP_039249;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
ERBB2	P04626	633	648	633	648	Alternative sequence	ID=VSP_055902;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	769	831	771	883	Alternative sequence	ID=VSP_055903;Note=In isoform 6. AYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK->TISNLFSNFAPRGPSACCEPTCWCHSGKGQDSLPREEWGRQRRFCLWGCRGEPRVLDTPGRSCPSAPPSSCLQPSLRQPLLLGPGPTRAGGSTQHLQRDTYGREPRVPGSGRASVNQKAKSAEALMCPQGAGKA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	831	883	771	883	Alternative sequence	ID=VSP_055903;Note=In isoform 6. AYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK->TISNLFSNFAPRGPSACCEPTCWCHSGKGQDSLPREEWGRQRRFCLWGCRGEPRVLDTPGRSCPSAPPSSCLQPSLRQPLLLGPGPTRAGGSTQHLQRDTYGREPRVPGSGRASVNQKAKSAEALMCPQGAGKA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	908	957	884	1255	Alternative sequence	ID=VSP_055904;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24722188;Dbxref=PMID:24722188
ERBB2	P04626	736	769	755	755	Natural variant	ID=VAR_055432;Note=In LNCR%3B somatic mutation%3B unknown pathological significance. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=dbSNP:rs121913469,PMID:15457249
ERBB2	P04626	736	769	768	768	Natural variant	ID=VAR_042097;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56366519,PMID:17344846
ERBB2	P04626	769	831	774	774	Natural variant	ID=VAR_055433;Note=In LNCR%3B somatic mutation%3B unknown pathological significance. M->MAYVM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=PMID:15457249
ERBB2	P04626	769	831	776	776	Natural variant	ID=VAR_042098;Note=In GASC%3B somatic mutation%3B unknown pathological significance. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15457249,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs28933369,PMID:15457249,PMID:17344846
ERBB2	P04626	769	831	779	779	Natural variant	ID=VAR_055434;Note=In LNCR%3B somatic mutation%3B unknown pathological significance. S->SVGS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=PMID:15457249
ERBB2	P04626	831	883	857	857	Natural variant	ID=VAR_042099;Note=In OC%3B somatic mutation%3B unknown pathological significance. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15457249,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs28933370,PMID:15457249,PMID:17344846
ERBB2	P04626	908	957	914	914	Natural variant	ID=VAR_055435;Note=In GLM%3B somatic mutation%3B unknown pathological significance. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15457249;Dbxref=dbSNP:rs28933368,PMID:15457249
ERBB2	P04626	146	191	147	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2A91
ERBB2	P04626	146	191	152	156	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MY6
ERBB2	P04626	146	191	164	166	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H3B
ERBB2	P04626	146	191	169	172	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MY6
ERBB2	P04626	146	191	175	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N8Z
ERBB2	P04626	146	191	182	184	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3H3B
ERBB2	P04626	633	648	635	637	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3N85
ERBB2	P04626	736	769	730	739	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	736	769	748	755	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	736	769	761	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	761	774	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	785	799	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	806	812	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	814	816	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	769	831	819	838	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	819	838	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	848	850	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	851	855	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	831	883	858	861	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	901	916	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	922	925	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	931	936	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ERBB2	P04626	908	957	949	958	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PP0
ETF1	P62495	287	339	2	437	Chain	ID=PRO_0000143138;Note=Eukaryotic peptide chain release factor subunit 1
ETF1	P62495	287	339	278	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	296	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	301	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	305	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	318	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1DT9
ETF1	P62495	287	339	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KTU
ETF1	P62495	287	339	336	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2KTU
EXOSC7	Q15024	19	53	2	291	Chain	ID=PRO_0000139963;Note=Exosome complex component RRP42
EXOSC7	Q15024	19	53	8	19	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC7	Q15024	19	53	24	26	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC7	Q15024	19	53	36	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC7	Q15024	19	53	45	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	128	174	1	439	Chain	ID=PRO_0000139971;Note=Exosome complex component RRP45
EXOSC9	Q06265	276	324	1	439	Chain	ID=PRO_0000139971;Note=Exosome complex component RRP45
EXOSC9	Q06265	128	174	1	268	Region	Note=ARE binding
EXOSC9	Q06265	276	324	297	297	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
EXOSC9	Q06265	276	324	306	306	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
EXOSC9	Q06265	276	324	297	297	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
EXOSC9	Q06265	276	324	297	297	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25755297,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733
EXOSC9	Q06265	128	174	128	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	128	174	146	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	276	324	244	277	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	276	324	287	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
EXOSC9	Q06265	276	324	291	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NN6
FARS2	O95363	257	301	287	287	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18611382,ECO:0000269|PubMed:19549855;Dbxref=PMID:18611382,PMID:19549855
FARS2	O95363	257	301	287	287	Binding site	Note=Substrate%3B via carbonyl oxygen;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18611382,ECO:0000269|PubMed:19549855;Dbxref=PMID:18611382,PMID:19549855
FARS2	O95363	257	301	280	280	Natural variant	ID=VAR_052643;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.3,ECO:0000269|Ref.7;Dbxref=dbSNP:rs11243011,PMID:14702039
FARS2	O95363	257	301	280	280	Natural variant	ID=VAR_052643;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.3,ECO:0000269|Ref.7;Dbxref=dbSNP:rs11243011,PMID:14702039
FARS2	O95363	257	301	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HFV
FARS2	O95363	257	301	256	258	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HFV
FARS2	O95363	257	301	261	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	261	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	271	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	271	281	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	284	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	284	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	296	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARS2	O95363	257	301	296	301	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MGW
FARSA	Q9Y285	95	128	2	508	Chain	ID=PRO_0000126824;Note=Phenylalanine--tRNA ligase alpha subunit
FARSA	Q9Y285	168	198	2	508	Chain	ID=PRO_0000126824;Note=Phenylalanine--tRNA ligase alpha subunit
FARSA	Q9Y285	398	424	2	508	Chain	ID=PRO_0000126824;Note=Phenylalanine--tRNA ligase alpha subunit
FARSA	Q9Y285	168	198	190	190	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FARSA	Q9Y285	168	198	193	193	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
FARSA	Q9Y285	168	198	169	199	Alternative sequence	ID=VSP_056196;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
FARSA	Q9Y285	168	198	179	179	Sequence conflict	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
FARSA	Q9Y285	95	128	98	108	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	109	111	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	112	114	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	119	121	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	95	128	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	168	198	167	175	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	168	198	194	198	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	398	424	397	399	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	398	424	404	407	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSA	Q9Y285	398	424	414	421	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	1	589	Chain	ID=PRO_0000127016;Note=Phenylalanine--tRNA ligase beta subunit
FARSB	Q9NSD9	417	448	1	589	Chain	ID=PRO_0000127016;Note=Phenylalanine--tRNA ligase beta subunit
FARSB	Q9NSD9	417	448	416	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	420	423	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	425	427	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	438	441	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	445	447	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	417	448	448	450	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	490	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	508	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	528	531	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FARSB	Q9NSD9	487	539	532	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3L4G
FTO	Q9C0B1	325	373	1	505	Chain	ID=PRO_0000286163;Note=Alpha-ketoglutarate-dependent dioxygenase FTO
FTO	Q9C0B1	250	298	1	505	Chain	ID=PRO_0000286163;Note=Alpha-ketoglutarate-dependent dioxygenase FTO
FTO	Q9C0B1	325	373	32	327	Region	Note=Fe2OG dioxygenase domain
FTO	Q9C0B1	250	298	32	327	Region	Note=Fe2OG dioxygenase domain
FTO	Q9C0B1	250	298	295	295	Binding site	Note=Alpha-ketoglutarate
FTO	Q9C0B1	325	373	1	445	Alternative sequence	ID=VSP_025002;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	250	298	1	445	Alternative sequence	ID=VSP_025002;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	325	373	1	399	Alternative sequence	ID=VSP_025003;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	250	298	1	399	Alternative sequence	ID=VSP_025003;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	325	373	1	378	Alternative sequence	ID=VSP_025004;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	250	298	1	378	Alternative sequence	ID=VSP_025004;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
FTO	Q9C0B1	250	298	271	271	Natural variant	ID=VAR_076423;Note=Found in a patient with microcephaly%2C developmental delay%2C behavioral abnormalities%2C dysmorphic facial features%2C hypotonia and other various phenotypic abnormalities%3B unknown pathological significance. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26740239;Dbxref=PMID:26740239
FTO	Q9C0B1	250	298	271	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	250	298	280	282	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	250	298	284	288	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	250	298	293	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	325	373	327	330	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F8P
FTO	Q9C0B1	325	373	331	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTO	Q9C0B1	325	373	361	377	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4IE5
FTSJ1	Q9UET6	253	319	1	329	Chain	ID=PRO_0000155575;Note=Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
FTSJ1	Q9UET6	190	218	1	329	Chain	ID=PRO_0000155575;Note=Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
FTSJ1	Q9UET6	253	319	271	271	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FXR1	P51114	467	534	2	621	Chain	ID=PRO_0000050106;Note=Fragile X mental retardation syndrome-related protein 1
FXR1	P51114	210	267	2	621	Chain	ID=PRO_0000050106;Note=Fragile X mental retardation syndrome-related protein 1
FXR1	P51114	210	267	222	251	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
FXR1	P51114	467	534	502	510	Compositional bias	Note=Poly-Arg
FXR1	P51114	467	534	483	483	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61584
FXR1	P51114	467	534	485	485	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
FXR1	P51114	467	534	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51116
FXR1	P51114	210	267	233	233	Natural variant	ID=VAR_036050;Note=In a breast cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
FXR1	P51114	210	267	213	216	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	218	224	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	227	234	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	239	245	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	250	256	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	257	260	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR1	P51114	210	267	261	268	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2CPQ
FXR2	P51116	220	277	1	673	Chain	ID=PRO_0000050110;Note=Fragile X mental retardation syndrome-related protein 2
FXR2	P51116	181	220	1	673	Chain	ID=PRO_0000050110;Note=Fragile X mental retardation syndrome-related protein 2
FXR2	P51116	220	277	232	261	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
FXR2	P51116	181	220	192	192	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
FXR2	P51116	220	277	252	252	Natural variant	ID=VAR_067039;Note=Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854734,PMID:15489334
GEMIN5	Q8TEQ6	722	798	1	1508	Chain	ID=PRO_0000051004;Note=Gem-associated protein 5
GEMIN5	Q8TEQ6	798	836	1	1508	Chain	ID=PRO_0000051004;Note=Gem-associated protein 5
GEMIN5	Q8TEQ6	836	877	1	1508	Chain	ID=PRO_0000051004;Note=Gem-associated protein 5
GEMIN5	Q8TEQ6	722	798	738	746	Compositional bias	Note=Poly-Lys
GEMIN5	Q8TEQ6	722	798	751	751	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GEMIN5	Q8TEQ6	722	798	757	757	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
GEMIN5	Q8TEQ6	722	798	770	770	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GEMIN5	Q8TEQ6	722	798	778	778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18691976,PMID:21406692,PMID:23186163
GEMIN5	Q8TEQ6	836	877	847	847	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
GEMIN5	Q8TEQ6	722	798	754	754	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
GFM1	Q96RP9	690	708	37	751	Chain	ID=PRO_0000007440;Note=Elongation factor G%2C mitochondrial
GFM1	Q96RP9	191	229	37	751	Chain	ID=PRO_0000007440;Note=Elongation factor G%2C mitochondrial
GFM1	Q96RP9	361	407	37	751	Chain	ID=PRO_0000007440;Note=Elongation factor G%2C mitochondrial
GFM1	Q96RP9	191	229	44	321	Domain	Note=tr-type G
GFM1	Q96RP9	191	229	215	215	Natural variant	ID=VAR_028303;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2303909,PMID:14702039
GFM1	Q96RP9	361	407	373	373	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
GFM2	Q969S9	101	143	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	360	406	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	101	143	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	360	406	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
GFM2	Q969S9	101	143	68	353	Domain	Note=tr-type G
GFM2	Q969S9	101	143	68	353	Domain	Note=tr-type G
GFM2	Q969S9	101	143	141	145	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03059
GFM2	Q969S9	101	143	141	145	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255|HAMAP-Rule:MF_03059
GFM2	Q969S9	360	406	361	407	Alternative sequence	ID=VSP_001363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GFM2	Q969S9	360	406	361	407	Alternative sequence	ID=VSP_001363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4
GLE1	Q53GS7	592	627	1	698	Chain	ID=PRO_0000204822;Note=Nucleoporin GLE1
GLE1	Q53GS7	107	144	1	698	Chain	ID=PRO_0000204822;Note=Nucleoporin GLE1
GLE1	Q53GS7	107	144	130	130	Natural variant	ID=VAR_024056;Note=G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17852725,PMID:15489334
GLE1	Q53GS7	107	144	144	144	Natural variant	ID=VAR_043874;Note=In LCCS1%3B allele Fin(Major)%3B does not affect subcellular localization. T->TPFQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18204449;Dbxref=PMID:18204449
GLE1	Q53GS7	592	627	617	617	Natural variant	ID=VAR_043876;Note=In LAAHD. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18204449;Dbxref=dbSNP:rs121434408,PMID:18204449
GLE1	Q53GS7	592	627	599	609	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B4F
GLE1	Q53GS7	592	627	617	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B4F
GRM5	P41594	877	908	21	1212	Chain	ID=PRO_0000012932;Note=Metabotropic glutamate receptor 5
GRM5	P41594	877	908	821	1212	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25042998;Dbxref=PMID:25042998
GRM5	P41594	877	908	877	908	Alternative sequence	ID=VSP_002030;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7908515;Dbxref=PMID:7908515
GRM5	P41594	877	908	896	1165	Alternative sequence	ID=VSP_047710;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
GSPT1	P15170	95	120	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	7	83	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	311	338	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	338	396	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	396	426	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	95	120	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	7	83	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	311	338	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	338	396	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	396	426	1	499	Chain	ID=PRO_0000091480;Note=Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
GSPT1	P15170	95	120	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	95	120	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	72	298	Domain	Note=tr-type G;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	81	88	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GSPT1	P15170	7	83	81	88	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
GSPT1	P15170	7	83	81	88	Region	Note=G1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	81	88	Region	Note=G1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01059
GSPT1	P15170	7	83	8	8	Alternative sequence	ID=VSP_042199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GSPT1	P15170	7	83	8	8	Alternative sequence	ID=VSP_042199;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
GTPBP1	O00178	406	467	1	669	Chain	ID=PRO_0000122469;Note=GTP-binding protein 1
GUF1	Q8N442	445	493	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
GUF1	Q8N442	245	312	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
GUF1	Q8N442	572	611	50	669	Chain	ID=PRO_0000256251;Note=Translation factor GUF1%2C mitochondrial
GUF1	Q8N442	245	312	66	247	Domain	Note=tr-type G
GUF1	Q8N442	572	611	609	609	Natural variant	ID=VAR_077804;Note=In EIEE40. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26486472;Dbxref=dbSNP:rs879255631,PMID:26486472
HABP4	Q5JVS0	171	224	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	333	395	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	225	247	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	248	275	1	413	Chain	ID=PRO_0000257972;Note=Intracellular hyaluronan-binding protein 4
HABP4	Q5JVS0	333	395	354	354	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14699138;Dbxref=PMID:14699138
HABP4	Q5JVS0	333	395	375	375	Modified residue	Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:14699138;Dbxref=PMID:14699138
HABP4	Q5JVS0	171	224	172	276	Alternative sequence	ID=VSP_052194;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HABP4	Q5JVS0	225	247	172	276	Alternative sequence	ID=VSP_052194;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HABP4	Q5JVS0	248	275	172	276	Alternative sequence	ID=VSP_052194;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
HABP4	Q5JVS0	333	395	388	389	Sequence conflict	Note=YG->NY;Ontology_term=ECO:0000305;evidence=ECO:0000305
HABP4	Q5JVS0	333	395	388	389	Sequence conflict	Note=YG->NY;Ontology_term=ECO:0000305;evidence=ECO:0000305
HARS2	P49590	61	101	34	506	Chain	ID=PRO_0000136336;Note=Probable histidine--tRNA ligase%2C mitochondrial
HARS2	P49590	211	244	34	506	Chain	ID=PRO_0000136336;Note=Probable histidine--tRNA ligase%2C mitochondrial
HARS2	P49590	61	101	67	67	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:23186163,PMID:24275569
HARS2	P49590	61	101	37	61	Alternative sequence	ID=VSP_055133;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HBS1L	Q9Y450	36	78	1	684	Chain	ID=PRO_0000091491;Note=HBS1-like protein
HBS1L	Q9Y450	78	143	1	684	Chain	ID=PRO_0000091491;Note=HBS1-like protein
HBS1L	Q9Y450	36	78	49	49	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HBS1L	Q9Y450	36	78	67	67	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
HBS1L	Q9Y450	78	143	117	117	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
HBS1L	Q9Y450	78	143	127	127	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
HBS1L	Q9Y450	36	78	37	78	Alternative sequence	ID=VSP_041068;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
HBS1L	Q9Y450	78	143	37	78	Alternative sequence	ID=VSP_041068;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
IGF2BP1	Q9NZI8	509	547	1	577	Chain	ID=PRO_0000282533;Note=Insulin-like growth factor 2 mRNA-binding protein 1
IGF2BP1	Q9NZI8	134	227	1	577	Chain	ID=PRO_0000282533;Note=Insulin-like growth factor 2 mRNA-binding protein 1
IGF2BP1	Q9NZI8	134	227	81	156	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
IGF2BP1	Q9NZI8	134	227	195	260	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP1	Q9NZI8	509	547	487	553	Domain	Note=KH 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP1	Q9NZI8	509	547	187	570	Region	Note=Necessary for interaction with ELAVL4 and binding to TAU mRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
IGF2BP1	Q9NZI8	134	227	187	570	Region	Note=Necessary for interaction with ELAVL4 and binding to TAU mRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250
IGF2BP1	Q9NZI8	134	227	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:20068231,PMID:23186163
IGF2BP1	Q9NZI8	509	547	528	528	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
IGF2BP1	Q9NZI8	134	227	135	273	Alternative sequence	ID=VSP_045366;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
IGF2BP1	Q9NZI8	134	227	213	214	Mutagenesis	Note=50-fold decrease in RNA-binding affinity%2C decreased location in cytoplasmic RNP%2C increased nuclear location%3B when associated with 294-E-L-295 and 423-E-L-424. KE->EL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12921532;Dbxref=PMID:12921532
IGF2BP1	Q9NZI8	509	547	508	517	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IGF2BP1	Q9NZI8	509	547	520	522	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IGF2BP1	Q9NZI8	509	547	533	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IGF2BP1	Q9NZI8	509	547	543	560	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3KRM
IGF2BP2	Q9Y6M1	135	225	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
IGF2BP2	Q9Y6M1	419	444	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
IGF2BP2	Q9Y6M1	444	488	1	599	Chain	ID=PRO_0000244496;Note=Insulin-like growth factor 2 mRNA-binding protein 2
IGF2BP2	Q9Y6M1	135	225	82	157	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
IGF2BP2	Q9Y6M1	135	225	193	258	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP2	Q9Y6M1	419	444	427	492	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP2	Q9Y6M1	444	488	427	492	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP2	Q9Y6M1	135	225	162	162	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:21406692;Dbxref=PMID:18669648,PMID:21406692
IGF2BP2	Q9Y6M1	135	225	164	164	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
IGF2BP2	Q9Y6M1	135	225	211	211	Mutagenesis	Note=Significantly impaired binding to ACTB transcript%2C but little effect on MYC transcript binding%2C accumulation in the nucleus%3B when associated with E-292. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C almost complete loss of ACTB and MYC transcript binding%2C almost complete loss of ELAVL1-%2C DHX9- and HNRNPU-binding and perturbed subcellular location%2C including accumulation in the nucleus and loss of localization to stress granules%3B when associated with E-292%3B 445-E-E-446 and 526-E-E-527. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23640942;Dbxref=PMID:23640942
IGF2BP2	Q9Y6M1	444	488	445	446	Mutagenesis	Note=Significantly impaired binding to ACTB and MYC transcripts%3B when associated with 527-E-E-528. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C almost complete loss of ACTB and MYC transcript binding%2C almost complete loss of ELAVL1-%2C DHX9- and HNRNPU-binding and perturbed subcellular location%2C including accumulation in the nucleus and loss of localization to stress granules%3B when associated with E-211%3B E-292 and 527-E-E-528. KK->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23640942;Dbxref=PMID:23640942
IGF2BP3	O00425	401	440	1	579	Chain	ID=PRO_0000282538;Note=Insulin-like growth factor 2 mRNA-binding protein 3
IGF2BP3	O00425	401	440	405	470	Domain	Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
IGF2BP3	O00425	401	440	423	424	Mutagenesis	Note=Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2%2C Modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-%2C DHX9- and HNRNPU-binding%2C nor on subcellular location%3B when associated with E-213%3B E-294 and 505-E-E-506. KQ->EE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23640942;Dbxref=PMID:23640942
IGF2BP3	O00425	401	440	410	410	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGF2BP3	O00425	401	440	410	410	Sequence conflict	Note=L->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
IGFBP5	P24593	189	229	21	272	Chain	ID=PRO_0000014385;Note=Insulin-like growth factor-binding protein 5
IGFBP5	P24593	189	229	189	263	Domain	Note=Thyroglobulin type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00500
IGFBP5	P24593	189	229	192	219	Disulfide bond	Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00500,ECO:0000269|PubMed:22117064;Dbxref=PMID:22117064
IL6	P05231	108	157	30	212	Chain	ID=PRO_0000015582;Note=Interleukin-6
IL6	P05231	108	157	30	212	Chain	ID=PRO_0000015582;Note=Interleukin-6
IL6	P05231	108	157	101	111	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2472117;Dbxref=PMID:2472117
IL6	P05231	108	157	101	111	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2472117;Dbxref=PMID:2472117
IL6	P05231	108	157	108	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IL6	P05231	108	157	108	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IL6	P05231	108	157	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J4L
IL6	P05231	108	157	134	136	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4J4L
IL6	P05231	108	157	137	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IL6	P05231	108	157	137	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ALU
IMPACT	Q9P2X3	73	93	1	320	Chain	ID=PRO_0000330850;Note=Protein IMPACT
IMPACT	Q9P2X3	253	298	1	320	Chain	ID=PRO_0000330850;Note=Protein IMPACT
IMPACT	Q9P2X3	73	93	14	116	Domain	Note=RWD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00179
IMPACT	Q9P2X3	253	298	297	297	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5GFD9
IMPACT	Q9P2X3	73	93	1	118	Alternative sequence	ID=VSP_033136;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
IMPACT	Q9P2X3	73	93	74	74	Natural variant	ID=VAR_077844;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27607563;Dbxref=dbSNP:rs544203385,PMID:27607563
INPP5E	Q9NRR6	386	426	1	641	Chain	ID=PRO_0000209747;Note=72 kDa inositol polyphosphate 5-phosphatase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24166846;Dbxref=PMID:24166846
INPP5E	Q9NRR6	426	462	1	641	Chain	ID=PRO_0000209747;Note=72 kDa inositol polyphosphate 5-phosphatase;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24166846;Dbxref=PMID:24166846
INPP5E	Q9NRR6	386	426	426	426	Natural variant	ID=VAR_077250;Note=In JBTS1. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23386033;Dbxref=PMID:23386033
INPP5E	Q9NRR6	426	462	426	426	Natural variant	ID=VAR_077250;Note=In JBTS1. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23386033;Dbxref=PMID:23386033
INPP5E	Q9NRR6	426	462	435	435	Natural variant	ID=VAR_063013;Note=In JBTS1%3B severe reduction of activity. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19668216,ECO:0000269|PubMed:23386033;Dbxref=dbSNP:rs121918129,PMID:19668216,PMID:23386033
INPP5E	Q9NRR6	386	426	389	399	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	386	426	402	413	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	386	426	416	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	426	462	432	445	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	426	462	450	452	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
INPP5E	Q9NRR6	426	462	457	459	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XSW
ITGA2	P17301	1086	1116	30	1181	Chain	ID=PRO_0000016233;Note=Integrin alpha-2
ITGA2	P17301	976	1013	30	1181	Chain	ID=PRO_0000016233;Note=Integrin alpha-2
ITGA2	P17301	1086	1116	30	1132	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
ITGA2	P17301	976	1013	30	1132	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
JMJD4	Q9H9V9	189	230	1	463	Chain	ID=PRO_0000291959;Note=JmjC domain-containing protein 4
JMJD4	Q9H9V9	320	369	1	463	Chain	ID=PRO_0000291959;Note=JmjC domain-containing protein 4
JMJD4	Q9H9V9	189	230	188	347	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
JMJD4	Q9H9V9	320	369	188	347	Domain	Note=JmjC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00538
JMJD4	Q9H9V9	320	369	354	369	Alternative sequence	ID=VSP_026324;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
KHDRBS1	Q07666	169	208	1	443	Chain	ID=PRO_0000050124;Note=KH domain-containing%2C RNA-binding%2C signal transduction-associated protein 1
KHDRBS1	Q07666	169	208	171	197	Domain	Note=KH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
KHDRBS1	Q07666	169	208	100	260	Region	Note=Involved in homodimerization;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26758068;Dbxref=PMID:26758068
KHDRBS1	Q07666	169	208	175	175	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
KHDRBS1	Q07666	169	208	183	183	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KHDRBS1	Q07666	169	208	175	175	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KHDRBS1	Q07666	169	208	169	207	Alternative sequence	ID=VSP_051720;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9013542;Dbxref=PMID:9013542
KHSRP	Q92945	158	182	2	711	Chain	ID=PRO_0000050137;Note=Far upstream element-binding protein 2
KHSRP	Q92945	115	128	2	711	Chain	ID=PRO_0000050137;Note=Far upstream element-binding protein 2
KHSRP	Q92945	158	182	144	208	Domain	Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
KHSRP	Q92945	158	182	68	496	Compositional bias	Note=Gly-rich
KHSRP	Q92945	115	128	68	496	Compositional bias	Note=Gly-rich
KHSRP	Q92945	115	128	125	125	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
KHSRP	Q92945	158	182	181	181	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
KHSRP	Q92945	115	128	121	121	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
KHSRP	Q92945	115	128	121	121	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
KHSRP	Q92945	158	182	153	159	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
KHSRP	Q92945	158	182	161	163	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
KHSRP	Q92945	158	182	165	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
KHSRP	Q92945	158	182	179	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2OPU
LARP4	Q71RC2	461	515	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	374	444	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	268	339	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	250	268	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	55	107	1	724	Chain	ID=PRO_0000207611;Note=La-related protein 4
LARP4	Q71RC2	268	339	203	281	Domain	Note=RRM
LARP4	Q71RC2	250	268	203	281	Domain	Note=RRM
LARP4	Q71RC2	268	339	111	303	Region	Note=Interaction with the poly-A tract of mRNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21098120;Dbxref=PMID:21098120
LARP4	Q71RC2	250	268	111	303	Region	Note=Interaction with the poly-A tract of mRNA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21098120;Dbxref=PMID:21098120
LARP4	Q71RC2	374	444	392	392	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
LARP4	Q71RC2	461	515	505	505	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LARP4	Q71RC2	55	107	55	55	Alternative sequence	ID=VSP_033812;Note=In isoform 4. E->EVSVFNT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LARP4	Q71RC2	55	107	97	194	Alternative sequence	ID=VSP_014611;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LARP4	Q71RC2	268	339	269	339	Alternative sequence	ID=VSP_045677;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
LARP4	Q71RC2	374	444	374	444	Alternative sequence	ID=VSP_046780;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LARP4	Q71RC2	461	515	446	724	Alternative sequence	ID=VSP_046781;Note=In isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
LARP4	Q71RC2	461	515	502	502	Natural variant	ID=VAR_055937;Note=N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15498874;Dbxref=dbSNP:rs17124715,PMID:15498874
LARP4	Q71RC2	374	444	422	422	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
LARP4B	Q92615	96	143	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	250	287	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	510	565	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	411	494	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
LARP4B	Q92615	250	287	240	307	Domain	Note=RRM
LARP4B	Q92615	411	494	419	419	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
LARP4B	Q92615	411	494	424	424	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
LARP4B	Q92615	411	494	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648;Dbxref=PMID:16964243,PMID:18669648
LARP4B	Q92615	411	494	451	451	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
LARP4B	Q92615	411	494	488	488	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LARP4B	Q92615	411	494	493	493	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6A0A2
LARP4B	Q92615	510	565	518	518	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332
LARP4B	Q92615	510	565	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
LARP4B	Q92615	510	565	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LARS2	Q15031	78	121	92	102	Motif	Note="HIGH" region
LARS2	Q15031	78	121	92	102	Motif	Note="HIGH" region
LARS2	Q15031	202	250	236	236	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LARS2	Q15031	202	250	236	236	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
LRPPRC	P42704	640	655	60	1394	Chain	ID=PRO_0000084467;Note=Leucine-rich PPR motif-containing protein%2C mitochondrial
LRPPRC	P42704	655	693	60	1394	Chain	ID=PRO_0000084467;Note=Leucine-rich PPR motif-containing protein%2C mitochondrial
LRPPRC	P42704	1275	1300	60	1394	Chain	ID=PRO_0000084467;Note=Leucine-rich PPR motif-containing protein%2C mitochondrial
LRPPRC	P42704	655	693	678	709	Repeat	Note=PPR 9
LRPPRC	P42704	1275	1300	1121	1394	Region	Note=RNA-binding
LRPPRC	P42704	640	655	648	648	Sequence conflict	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRPPRC	P42704	655	693	676	676	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
LRRC47	Q8N1G4	359	398	2	583	Chain	ID=PRO_0000223926;Note=Leucine-rich repeat-containing protein 47
LSM14B	Q9BX40	142	198	2	385	Chain	ID=PRO_0000187093;Note=Protein LSM14 homolog B
LSM14B	Q9BX40	198	224	2	385	Chain	ID=PRO_0000187093;Note=Protein LSM14 homolog B
LSM14B	Q9BX40	142	198	154	154	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
LSM14B	Q9BX40	142	198	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
LSM14B	Q9BX40	142	198	45	142	Alternative sequence	ID=VSP_014659;Note=In isoform 3. SFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAASSLLSQQYAASLGL->MAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGCLFCFRSLFTYTQSHIVLFRVPTGPGTLEREEMER;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
LSM14B	Q9BX40	142	198	143	220	Alternative sequence	ID=VSP_014660;Note=In isoform 2. GAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQ->EKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSPCS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
LSM14B	Q9BX40	198	224	143	220	Alternative sequence	ID=VSP_014660;Note=In isoform 2. GAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQ->EKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSPCS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MAGOH	P61326	49	86	1	146	Chain	ID=PRO_0000174145;Note=Protein mago nashi homolog
MAGOH	P61326	49	86	50	86	Alternative sequence	ID=VSP_056246;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MAGOH	P61326	49	86	66	68	Mutagenesis	Note=Slightly reduced nonsense-mediated decay activity. DSE->RSR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16209946;Dbxref=PMID:16209946
MAGOH	P61326	49	86	68	68	Mutagenesis	Note=Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs%3B when associated with R-72%3B K-73 and R-117. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19410547;Dbxref=PMID:19410547
MAGOH	P61326	49	86	72	73	Mutagenesis	Note=Fully active. ED->RK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16209946;Dbxref=PMID:16209946
MAGOH	P61326	49	86	72	72	Mutagenesis	Note=Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs%3B when associated with R-68%3B K-73 and R-117. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19410547;Dbxref=PMID:19410547
MAGOH	P61326	49	86	73	73	Mutagenesis	Note=Abolishes interaction with PYM1 leading to increase EJC association with splices mRNAs%3B when associated with R-68%3B R-72 and R-117. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19410547;Dbxref=PMID:19410547
MAGOH	P61326	49	86	85	87	Mutagenesis	Note=Fully active. RQE->EQR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16209946;Dbxref=PMID:16209946
MAGOH	P61326	49	86	44	52	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MAGOH	P61326	49	86	54	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MAGOH	P61326	49	86	69	71	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MAGOH	P61326	49	86	74	77	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XB2
MAGOH	P61326	49	86	85	92	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1P27
MAPKAPK5	Q8IW41	193	220	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
MAPKAPK5	Q8IW41	407	442	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
MAPKAPK5	Q8IW41	131	161	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
MAPKAPK5	Q8IW41	193	220	22	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPKAPK5	Q8IW41	131	161	22	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MAPKAPK5	Q8IW41	407	442	409	440	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
MAPKAPK5	Q8IW41	131	161	148	148	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
MAPKAPK5	Q8IW41	193	220	212	212	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808055;Dbxref=PMID:12808055
MAPKAPK5	Q8IW41	407	442	407	408	Alternative sequence	ID=VSP_011597;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
MAPKAPK5	Q8IW41	193	220	212	212	Mutagenesis	Note=Mimicks phosphorylation state and displays a slightly higher protein kinase activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808055;Dbxref=PMID:12808055
MCTS1	Q9ULC4	4	54	1	181	Chain	ID=PRO_0000344786;Note=Malignant T-cell-amplified sequence 1
MCTS1	Q9ULC4	4	54	1	22	Alternative sequence	ID=VSP_034856;Note=In isoform 2. MFKKFDEKENVSNCIQLKTSVI->MENYSFLDKE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MCTS1	Q9ULC4	4	54	1	4	Alternative sequence	ID=VSP_041352;Note=In isoform 3. MFKK->MGKGR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MCTS1	Q9ULC4	4	54	25	25	Sequence conflict	Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MCTS1	Q9ULC4	4	54	7	10	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	11	16	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	19	32	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	34	39	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	40	43	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
MCTS1	Q9ULC4	4	54	50	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3R90
METAP1	P53582	262	310	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
METAP1	P53582	218	262	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
METAP1	P53582	310	332	2	386	Chain	ID=PRO_0000148967;Note=Methionine aminopeptidase 1
METAP1	P53582	218	262	220	220	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	218	262	231	231	Metal binding	Note=Divalent metal cation 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	218	262	231	231	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	262	310	294	294	Metal binding	Note=Divalent metal cation 2%3B catalytic%3B via tele nitrogen;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	310	332	327	327	Metal binding	Note=Divalent metal cation 2%3B catalytic;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16274222,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16274222,PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	262	310	301	301	Binding site	Note=Substrate;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_03174,ECO:0000269|PubMed:16724298,ECO:0000269|PubMed:16823043,ECO:0000269|PubMed:17114291;Dbxref=PMID:16724298,PMID:16823043,PMID:17114291
METAP1	P53582	218	262	216	225	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	218	262	228	237	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	218	262	243	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	271	282	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	293	295	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	297	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	262	310	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	310	332	309	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	310	332	323	326	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METAP1	P53582	310	332	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2B3H
METTL14	Q9HCE5	215	246	1	456	Chain	ID=PRO_0000325790;Note=N6-adenosine-methyltransferase non-catalytic subunit
METTL14	Q9HCE5	215	246	237	238	Region	Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	245	254	Region	Note=Positively charged region required for RNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	242	242	Binding site	Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	245	245	Binding site	Note=Interaction with METTL3;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL0,ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	245	245	Mutagenesis	Note=Reduced RNA-binding. Reduced RNA-binding%3B when associated with E-255. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL14	Q9HCE5	215	246	213	217	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL14	Q9HCE5	215	246	221	223	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL14	Q9HCE5	215	246	225	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL14	Q9HCE5	215	246	240	251	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL16	Q86W50	0	42	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
METTL16	Q86W50	109	156	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
METTL16	Q86W50	266	296	1	562	Chain	ID=PRO_0000310767;Note=U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
METTL16	Q86W50	266	296	289	400	Region	Note=VCR 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28525753;Dbxref=PMID:28525753
METTL16	Q86W50	109	156	110	110	Binding site	Note=S-adenosyl-L-methionine%3B via carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2H00,ECO:0000269|Ref.13
METTL16	Q86W50	109	156	133	133	Binding site	Note=S-adenosyl-L-methionine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2H00,ECO:0000269|Ref.13
METTL16	Q86W50	266	296	225	562	Alternative sequence	ID=VSP_029341;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
METTL16	Q86W50	0	42	39	39	Sequence conflict	Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
METTL16	Q86W50	0	42	5	7	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	0	42	12	15	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	0	42	20	26	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	0	42	28	31	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	105	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	112	115	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	116	125	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	128	134	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	136	148	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	152	154	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	109	156	155	159	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	266	296	268	277	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL16	Q86W50	266	296	280	289	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6B91
METTL17	Q9H7H0	76	121	20	456	Chain	ID=PRO_0000312163;Note=Methyltransferase-like protein 17%2C mitochondrial
METTL3	Q86U44	435	447	2	580	Chain	ID=PRO_0000207630;Note=N6-adenosine-methyltransferase catalytic subunit
METTL3	Q86U44	484	506	2	580	Chain	ID=PRO_0000207630;Note=N6-adenosine-methyltransferase catalytic subunit
METTL3	Q86U44	435	447	438	438	Binding site	Note=Interaction with METTL14;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL3	Q86U44	435	447	441	441	Binding site	Note=Interaction with METTL14;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
METTL3	Q86U44	484	506	486	505	Alternative sequence	ID=VSP_007865;Note=In isoform 2. GVKGNPQGFNQGLDCDVIVA->SSSGAQFNRWSTKKNHLISY;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
METTL3	Q86U44	484	506	506	580	Alternative sequence	ID=VSP_007866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
METTL3	Q86U44	435	447	436	446	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL3	Q86U44	484	506	480	489	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
METTL3	Q86U44	484	506	498	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
MIF4GD	A9UHW6	64	116	1	222	Chain	ID=PRO_0000337089;Note=MIF4G domain-containing protein
MIF4GD	A9UHW6	64	116	3	205	Domain	Note=MIF4G
MKNK1	Q9BUB5	256	321	1	465	Chain	ID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1	Q9BUB5	164	205	1	465	Chain	ID=PRO_0000086334;Note=MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1	Q9BUB5	256	321	49	374	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK1	Q9BUB5	164	205	49	374	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK1	Q9BUB5	164	205	165	205	Alternative sequence	ID=VSP_007352;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15350534,ECO:0000303|PubMed:9155018;Dbxref=PMID:15350534,PMID:9155018
MKNK1	Q9BUB5	256	321	308	308	Natural variant	ID=VAR_040803;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55791614,PMID:17344846
MKNK1	Q9BUB5	256	321	271	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW6
MKNK1	Q9BUB5	256	321	277	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2HW6
MKNK2	Q9HBH9	250	315	1	465	Chain	ID=PRO_0000086336;Note=MAP kinase-interacting serine/threonine-protein kinase 2
MKNK2	Q9HBH9	250	315	1	465	Chain	ID=PRO_0000086336;Note=MAP kinase-interacting serine/threonine-protein kinase 2
MKNK2	Q9HBH9	250	315	84	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK2	Q9HBH9	250	315	84	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
MKNK2	Q9HBH9	250	315	299	299	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	299	299	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	311	311	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	311	311	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	314	314	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	314	314	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16216586,ECO:0000269|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
MKNK2	Q9HBH9	250	315	261	261	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MKNK2	Q9HBH9	250	315	261	261	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MKNK2	Q9HBH9	250	315	254	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	254	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	259	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	259	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	267	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	267	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	273	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	273	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	276	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	276	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	312	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MKNK2	Q9HBH9	250	315	312	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AC3
MOV10	Q9HCE1	540	593	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	836	861	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	279	323	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	46	113	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	540	593	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	836	861	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	279	323	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	46	113	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	540	593	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	836	861	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	279	323	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	46	113	1	1003	Chain	ID=PRO_0000080704;Note=Putative helicase MOV-10
MOV10	Q9HCE1	432	490	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MOV10	Q9HCE1	432	490	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MOV10	Q9HCE1	432	490	432	432	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
MOV10	Q9HCE1	46	113	47	56	Alternative sequence	ID=VSP_037305;Note=In isoform 3. FGTPAPGFSS->LASSKSILQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	47	56	Alternative sequence	ID=VSP_037305;Note=In isoform 3. FGTPAPGFSS->LASSKSILQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	47	56	Alternative sequence	ID=VSP_037305;Note=In isoform 3. FGTPAPGFSS->LASSKSILQS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	540	593	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	432	490	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	279	323	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	540	593	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	432	490	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	279	323	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	540	593	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	432	490	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	279	323	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	46	113	57	1003	Alternative sequence	ID=VSP_037306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10997877;Dbxref=PMID:10997877
MOV10	Q9HCE1	836	861	838	900	Alternative sequence	ID=VSP_010943;Note=In isoform 2. EKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK->RSSVTSKGGAPPPDGTSLISRPLGRGSRSLGLCWLRISEEHQGQLPPPFVPQLPGLLPGSLLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MOV10	Q9HCE1	836	861	838	900	Alternative sequence	ID=VSP_010943;Note=In isoform 2. EKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK->RSSVTSKGGAPPPDGTSLISRPLGRGSRSLGLCWLRISEEHQGQLPPPFVPQLPGLLPGSLLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MOV10	Q9HCE1	836	861	838	900	Alternative sequence	ID=VSP_010943;Note=In isoform 2. EKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK->RSSVTSKGGAPPPDGTSLISRPLGRGSRSLGLCWLRISEEHQGQLPPPFVPQLPGLLPGSLLH;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3
MOV10	Q9HCE1	46	113	98	98	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MOV10	Q9HCE1	46	113	98	98	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MOV10	Q9HCE1	46	113	98	98	Sequence conflict	Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
MRPL2	Q5T653	173	210	61	305	Chain	ID=PRO_0000261640;Note=39S ribosomal protein L2%2C mitochondrial
MRPL2	Q5T653	173	210	181	183	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL2	Q5T653	173	210	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL2	Q5T653	173	210	192	196	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL2	Q5T653	173	210	200	202	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOL
MRPL2	Q5T653	173	210	204	207	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOL
MRPL27	Q9P0M9	13	57	1	30	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q32PC3
MRPL27	Q9P0M9	13	57	31	148	Chain	ID=PRO_0000181229;Note=39S ribosomal protein L27%2C mitochondrial
MRPL27	Q9P0M9	13	57	24	24	Natural variant	ID=VAR_052023;Note=T->A;Dbxref=dbSNP:rs17776919
MRPL27	Q9P0M9	13	57	52	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	41	348	Chain	ID=PRO_0000077253;Note=39S ribosomal protein L3%2C mitochondrial
MRPL3	P09001	123	156	116	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	126	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	135	138	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	140	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL3	P09001	123	156	154	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	30	423	Chain	ID=PRO_0000045905;Note=39S ribosomal protein L37%2C mitochondrial
MRPL37	Q9BZE1	215	277	206	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	218	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	229	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	242	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	257	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	261	264	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL37	Q9BZE1	215	277	265	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	176	180	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	182	186	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	188	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	194	196	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL47	Q9HD33	178	209	206	237	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPL9	Q9BYD2	145	162	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
MRPL9	Q9BYD2	196	224	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
MRPL9	Q9BYD2	162	196	53	267	Chain	ID=PRO_0000030550;Note=39S ribosomal protein L9%2C mitochondrial
MRPL9	Q9BYD2	196	224	210	210	Natural variant	ID=VAR_028137;Note=E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11279069;Dbxref=dbSNP:rs8480,PMID:11279069
MRPS11	P82912	61	93	62	94	Alternative sequence	ID=VSP_005720;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
MRPS14	O60783	15	68	1	128	Chain	ID=PRO_0000131013;Note=28S ribosomal protein S14%2C mitochondrial
MRPS16	Q9Y3D3	4	91	1	34	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255
MRPS16	Q9Y3D3	4	91	35	137	Chain	ID=PRO_0000030618;Note=28S ribosomal protein S16%2C mitochondrial
MRPS16	Q9Y3D3	4	91	12	12	Natural variant	ID=VAR_031525;Note=Y->H;Dbxref=dbSNP:rs7905009
MRPS18A	Q9NVS2	48	84	35	196	Chain	ID=PRO_0000030625;Note=39S ribosomal protein S18a%2C mitochondrial
MRPS18A	Q9NVS2	48	84	48	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPS18A	Q9NVS2	48	84	73	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OOM
MRPS2	Q9Y399	14	56	1	296	Chain	ID=PRO_0000134343;Note=28S ribosomal protein S2%2C mitochondrial
MRPS2	Q9Y399	14	56	1	296	Chain	ID=PRO_0000134343;Note=28S ribosomal protein S2%2C mitochondrial
MRPS27	Q92552	279	335	37	414	Chain	ID=PRO_0000087712;Note=28S ribosomal protein S27%2C mitochondrial
MRPS27	Q92552	279	335	284	284	Natural variant	ID=VAR_047026;Note=Polymorphism%3B confirmed at protein level. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17488105,ECO:0000269|PubMed:9039502;Dbxref=dbSNP:rs3209157,PMID:17488105,PMID:9039502
MRPS5	P82675	46	92	1	430	Chain	ID=PRO_0000131685;Note=28S ribosomal protein S5%2C mitochondrial
MTFMT	Q96DP5	140	180	141	144	Alternative sequence	ID=VSP_057059;Note=In isoform 2. GILN->SFQF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTFMT	Q96DP5	140	180	145	389	Alternative sequence	ID=VSP_057060;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTG2	Q9H4K7	156	229	1	406	Chain	ID=PRO_0000205429;Note=Mitochondrial ribosome-associated GTPase 2
MTG2	Q9H4K7	156	229	225	390	Domain	Note=OBG-type G
MTG2	Q9H4K7	156	229	15	406	Region	Note=Localized in the mitochondria
MTG2	Q9H4K7	156	229	30	406	Region	Note=Not localized in the mitochondria
MTG2	Q9H4K7	156	229	1	228	Alternative sequence	ID=VSP_056672;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
MTIF2	P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
MTIF2	P46199	221	280	178	348	Domain	Note=tr-type G
MTIF2	P46199	221	280	178	348	Domain	Note=tr-type G
MTIF2	P46199	221	280	178	348	Domain	Note=tr-type G
MTIF2	P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTIF2	P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12932832,ECO:0000269|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
MTIF2	P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12932832,ECO:0000269|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
MTIF2	P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12932832,ECO:0000269|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
MTOR	P42345	1562	1588	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	2011	2072	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	838	883	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	235	280	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	471	513	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	595	667	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	1010	1039	1	2549	Chain	ID=PRO_0000088808;Note=Serine/threonine-protein kinase mTOR
MTOR	P42345	235	280	222	276	Repeat	Note=HEAT 6
MTOR	P42345	235	280	277	313	Repeat	Note=HEAT 7
MTOR	P42345	471	513	446	494	Repeat	Note=HEAT 11
MTOR	P42345	471	513	495	529	Repeat	Note=HEAT 12
MTOR	P42345	595	667	564	596	Repeat	Note=HEAT 14
MTOR	P42345	595	667	597	636	Repeat	Note=HEAT 15
MTOR	P42345	595	667	637	683	Repeat	Note=HEAT 16
MTOR	P42345	838	883	814	853	Repeat	Note=HEAT 20
MTOR	P42345	838	883	857	893	Repeat	Note=HEAT 21
MTOR	P42345	1010	1039	989	1027	Repeat	Note=HEAT 24
MTOR	P42345	1010	1039	1029	1068	Repeat	Note=HEAT 25
MTOR	P42345	1562	1588	1382	1982	Domain	Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534
MTOR	P42345	1562	1588	1542	1574	Repeat	Note=TPR 7
MTOR	P42345	1562	1588	1575	1614	Repeat	Note=TPR 8
MTOR	P42345	235	280	1	651	Region	Note=Interaction with NBN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23762398;Dbxref=PMID:23762398
MTOR	P42345	471	513	1	651	Region	Note=Interaction with NBN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23762398;Dbxref=PMID:23762398
MTOR	P42345	595	667	1	651	Region	Note=Interaction with NBN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23762398;Dbxref=PMID:23762398
MTOR	P42345	2011	2072	2012	2144	Region	Note=Sufficient for interaction with the FKBP1A/rapamycin complex;Ontology_term=ECO:0000250;evidence=ECO:0000250
MTOR	P42345	595	667	624	624	Natural variant	ID=VAR_078824;Note=In FCORD2%3B somatic mutation%3B unknown pathological significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25799227;Dbxref=dbSNP:rs913197212,PMID:25799227
MTOR	P42345	2011	2072	2011	2011	Natural variant	ID=VAR_041542;Note=In an ovarian mucinous carcinoma sample%3B somatic mutation. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
MTOR	P42345	471	513	482	484	Sequence conflict	Note=VFT->FFN;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	471	513	489	489	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	471	513	513	513	Sequence conflict	Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	838	883	857	857	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
MTOR	P42345	1562	1588	1557	1577	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	1562	1588	1584	1586	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	1562	1588	1587	1605	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	2011	2072	1985	2020	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5WBY
MTOR	P42345	2011	2072	2025	2039	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DRI
MTOR	P42345	2011	2072	2044	2058	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DRI
MTOR	P42345	2011	2072	2065	2091	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DRI
MTPN	P58546	62	90	2	118	Chain	ID=PRO_0000067031;Note=Myotrophin
MTPN	P58546	62	90	34	66	Repeat	Note=ANK 2
MTPN	P58546	62	90	67	99	Repeat	Note=ANK 3
MTPN	P58546	62	90	71	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AAA
MTPN	P58546	62	90	81	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AAA
MTRF1	O75570	375	408	407	407	Natural variant	ID=VAR_051789;Note=I->V;Dbxref=dbSNP:rs9315812
MTRF1	O75570	375	408	407	407	Natural variant	ID=VAR_051789;Note=I->V;Dbxref=dbSNP:rs9315812
NARS2	Q96I59	171	198	15	477	Chain	ID=PRO_0000250722;Note=Probable asparagine--tRNA ligase%2C mitochondrial
NARS2	Q96I59	171	198	1	227	Alternative sequence	ID=VSP_054120;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAT10	Q9H0A0	904	937	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
NAT10	Q9H0A0	864	904	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
NAT10	Q9H0A0	769	806	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
NAT10	Q9H0A0	962	989	1	1025	Chain	ID=PRO_0000215883;Note=RNA cytidine acetyltransferase
NAT10	Q9H0A0	904	937	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19303003;Dbxref=PMID:19303003
NAT10	Q9H0A0	864	904	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19303003;Dbxref=PMID:19303003
NAT10	Q9H0A0	769	806	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19303003;Dbxref=PMID:19303003
NAT10	Q9H0A0	962	989	702	1025	Region	Note=Required for localization to the nucleolus and midbody;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19303003;Dbxref=PMID:19303003
NAT10	Q9H0A0	904	937	934	934	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NAT10	Q9H0A0	962	989	984	984	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NAT10	Q9H0A0	962	989	987	987	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
NAT10	Q9H0A0	962	989	983	983	Natural variant	ID=VAR_061894;Note=A->T;Dbxref=dbSNP:rs36006049
NAT10	Q9H0A0	864	904	879	879	Sequence conflict	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
NAT10	Q9H0A0	962	989	971	971	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCBP1	Q09161	227	299	1	790	Chain	ID=PRO_0000089364;Note=Nuclear cap-binding protein subunit 1
NCBP1	Q09161	127	163	1	790	Chain	ID=PRO_0000089364;Note=Nuclear cap-binding protein subunit 1
NCBP1	Q09161	227	299	28	240	Domain	Note=MIF4G
NCBP1	Q09161	127	163	28	240	Domain	Note=MIF4G
NCBP1	Q09161	127	163	159	159	Sequence conflict	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305
NCBP1	Q09161	127	163	121	136	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	127	163	138	140	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N52
NCBP1	Q09161	127	163	142	154	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	127	163	155	157	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	127	163	159	161	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6D0Y
NCBP1	Q09161	127	163	163	174	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	228	241	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	242	244	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	247	249	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N54
NCBP1	Q09161	227	299	252	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	257	259	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	262	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	294	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H2V
NCBP1	Q09161	227	299	298	301	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1N52
NCL	P19338	204	270	2	710	Chain	ID=PRO_0000081691;Note=Nucleolin
NCL	P19338	204	270	185	209	Compositional bias	Note=Asp/Glu-rich (acidic)
NCL	P19338	204	270	234	271	Compositional bias	Note=Asp/Glu-rich (acidic)
NCL	P19338	204	270	206	206	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17487921,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17487921,PMID:18669648,PMID:23186163
NCL	P19338	204	270	214	214	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NDUFA7	O95182	34	83	2	113	Chain	ID=PRO_0000118834;Note=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
NDUFA7	O95182	34	83	40	40	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1P6
NDUFA7	O95182	34	83	66	66	Natural variant	ID=VAR_050589;Note=P->A;Dbxref=dbSNP:rs2288415
NDUFA7	O95182	34	83	54	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NDUFA7	O95182	34	83	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5XTB
NOLC1	Q14978	329	366	1	699	Chain	ID=PRO_0000096942;Note=Nucleolar and coiled-body phosphoprotein 1
NOLC1	Q14978	329	366	325	336	Repeat	Note=Acidic serine cluster 6
NOLC1	Q14978	329	366	363	375	Repeat	Note=Acidic serine cluster 7
NOLC1	Q14978	329	366	84	566	Region	Note=11 X 12 AA approximate repeats of an acidic serine cluster
NOLC1	Q14978	329	366	204	382	Region	Note=Interaction with RPA194
NOLC1	Q14978	329	366	362	362	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NOLC1	Q14978	329	366	363	363	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
NOLC1	Q14978	329	366	366	366	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
NOLC1	Q14978	329	366	342	342	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
NOLC1	Q14978	329	366	347	347	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
OGFOD1	Q8N543	219	262	1	542	Chain	ID=PRO_0000288974;Note=Prolyl 3-hydroxylase OGFOD1
OGFOD1	Q8N543	262	300	1	542	Chain	ID=PRO_0000288974;Note=Prolyl 3-hydroxylase OGFOD1
OGFOD1	Q8N543	219	262	134	239	Domain	Note=Fe2OG dioxygenase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00805
OGFOD1	Q8N543	219	262	230	230	Binding site	Note=2-oxoglutarate;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00805,ECO:0000305|PubMed:25728928;Dbxref=PMID:25728928
OGFOD1	Q8N543	219	262	218	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	219	262	230	238	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	266	269	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	272	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	277	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
OGFOD1	Q8N543	262	300	291	297	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NHX
PABPC1	P11940	324	415	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
PABPC1	P11940	445	482	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
PABPC1	P11940	246	292	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
PABPC1	P11940	246	292	191	268	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC1	P11940	324	415	294	370	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC1	P11940	246	292	166	289	Region	Note=CSDE1-binding
PABPC1	P11940	324	415	385	385	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PABPC1	P11940	445	482	455	455	Modified residue	Note=Omega-N-methylated arginine%3B by CARM1%3B partial;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	445	482	460	460	Modified residue	Note=Omega-N-methylated arginine%3B by CARM1%3B partial;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	445	482	475	475	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29341
PABPC1	P11940	445	482	481	481	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
PABPC1	P11940	445	482	447	535	Alternative sequence	ID=VSP_009846;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5
PABPC1	P11940	445	482	455	455	Mutagenesis	Note=Greatly reduces methylation by CARM1 (in vitro)%3B when associated with A-460. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	445	482	460	460	Mutagenesis	Note=Greatly reduces methylation by CARM1 (in vitro)%3B when associated with A-455. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11850402;Dbxref=PMID:11850402
PABPC1	P11940	324	415	410	410	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305
PABPC4	Q13310	468	497	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	246	292	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	292	324	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	324	415	1	644	Chain	ID=PRO_0000081703;Note=Polyadenylate-binding protein 4
PABPC4	Q13310	246	292	191	268	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC4	Q13310	292	324	294	370	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC4	Q13310	324	415	294	370	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
PABPC4	Q13310	292	324	304	304	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PABPC4	Q13310	292	324	315	315	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
PABPC4	Q13310	292	324	319	319	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PABPC4	Q13310	324	415	361	361	Modified residue	Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.6
PABPC4	Q13310	324	415	364	364	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PABPC4	Q13310	324	415	361	361	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PABPC4	Q13310	324	415	375	375	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
PABPC4	Q13310	468	497	468	468	Alternative sequence	ID=VSP_043357;Note=In isoform 3. T->TGNAPASRGLPTTTQRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PABPC4	Q13310	468	497	470	497	Alternative sequence	ID=VSP_013335;Note=In isoform 2. SECPDRLAMDFGGAGAAQQGLTDSCQSG->NAPASRGLPTTTQRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PABPC4	Q13310	324	415	382	382	Natural variant	ID=VAR_054048;Note=Y->F;Dbxref=dbSNP:rs9820
PAIP1	Q9H074	145	207	1	479	Chain	ID=PRO_0000058177;Note=Polyadenylate-binding protein-interacting protein 1
PAIP1	Q9H074	282	324	1	479	Chain	ID=PRO_0000058177;Note=Polyadenylate-binding protein-interacting protein 1
PAIP1	Q9H074	145	207	159	376	Domain	Note=MIF4G
PAIP1	Q9H074	282	324	159	376	Domain	Note=MIF4G
PAIP1	Q9H074	145	207	158	171	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	145	207	173	175	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	145	207	176	190	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	145	207	194	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	282	324	288	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	282	324	294	309	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP1	Q9H074	282	324	313	336	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3RK6
PAIP2	Q9BPZ3	46	106	1	127	Chain	ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2
PAIP2	Q9BPZ3	46	106	1	127	Chain	ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2
PAIP2	Q9BPZ3	46	106	1	127	Chain	ID=PRO_0000058179;Note=Polyadenylate-binding protein-interacting protein 2
PAIP2	Q9BPZ3	46	106	22	75	Region	Note=PABPC1-interacting motif-1 (PAM1)
PAIP2	Q9BPZ3	46	106	22	75	Region	Note=PABPC1-interacting motif-1 (PAM1)
PAIP2	Q9BPZ3	46	106	22	75	Region	Note=PABPC1-interacting motif-1 (PAM1)
PAIP2	Q9BPZ3	46	106	105	120	Region	Note=PABPC1-interacting motif-2 (PAM2)
PAIP2	Q9BPZ3	46	106	105	120	Region	Note=PABPC1-interacting motif-2 (PAM2)
PAIP2	Q9BPZ3	46	106	105	120	Region	Note=PABPC1-interacting motif-2 (PAM2)
PAIP2	Q9BPZ3	46	106	33	72	Compositional bias	Note=Glu-rich
PAIP2	Q9BPZ3	46	106	33	72	Compositional bias	Note=Glu-rich
PAIP2	Q9BPZ3	46	106	33	72	Compositional bias	Note=Glu-rich
PAIP2	Q9BPZ3	46	106	98	98	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAIP2	Q9BPZ3	46	106	98	98	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAIP2	Q9BPZ3	46	106	98	98	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PAIP2B	Q9ULR5	46	105	1	123	Chain	ID=PRO_0000317294;Note=Polyadenylate-binding protein-interacting protein 2B
PASK	Q96RG2	143	200	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	1066	1111	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	1024	1066	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	143	200	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	1066	1111	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	1024	1066	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	880	925	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	838	880	1	1323	Chain	ID=PRO_0000086480;Note=PAS domain-containing serine/threonine-protein kinase
PASK	Q96RG2	143	200	119	190	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
PASK	Q96RG2	143	200	119	190	Domain	Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140
PASK	Q96RG2	1066	1111	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1024	1066	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1066	1111	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1024	1066	999	1251	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
PASK	Q96RG2	1066	1111	1082	1089	Nucleotide binding	Note=ATP
PASK	Q96RG2	1066	1111	1082	1089	Nucleotide binding	Note=ATP
PASK	Q96RG2	1024	1066	1028	1028	Binding site	Note=ATP
PASK	Q96RG2	1024	1066	1028	1028	Binding site	Note=ATP
PASK	Q96RG2	1066	1111	1111	1111	Alternative sequence	ID=VSP_009302;Note=In isoform 2. Q->QVRAGQSR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
PASK	Q96RG2	1066	1111	1111	1111	Alternative sequence	ID=VSP_009302;Note=In isoform 2. Q->QVRAGQSR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8590280;Dbxref=PMID:8590280
PASK	Q96RG2	838	880	844	844	Natural variant	ID=VAR_040991;Note=P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs36082918,PMID:17344846
PASK	Q96RG2	1024	1066	1028	1028	Mutagenesis	Note=Loss of autophosphorylating activity. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11459942,ECO:0000269|PubMed:20943661;Dbxref=PMID:11459942,PMID:20943661
PASK	Q96RG2	1024	1066	1028	1028	Mutagenesis	Note=Loss of autophosphorylating activity. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11459942,ECO:0000269|PubMed:20943661;Dbxref=PMID:11459942,PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Induces lower protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Induces lower protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Does not affect protein kinase activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	1024	1066	1058	1058	Mutagenesis	Note=Does not affect protein kinase activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20943661;Dbxref=PMID:20943661
PASK	Q96RG2	838	880	850	850	Sequence conflict	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	880	925	899	899	Sequence conflict	Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1048	1048	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1048	1048	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1062	1062	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	1024	1066	1062	1062	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PASK	Q96RG2	143	200	143	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	143	147	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	151	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	151	155	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	159	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	159	161	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	167	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	167	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	174	176	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	174	176	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	177	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	177	181	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	188	191	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	143	200	198	203	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LL8
PASK	Q96RG2	1024	1066	1023	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1023	1032	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1039	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1039	1043	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1044	1046	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1044	1046	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1047	1050	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1047	1050	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1051	1056	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1024	1066	1051	1056	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1067	1072	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1067	1072	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1074	1082	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1074	1082	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1090	1095	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1090	1095	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1102	1121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PASK	Q96RG2	1066	1111	1102	1121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3DLS
PCIF1	Q9H4Z3	83	129	1	704	Chain	ID=PRO_0000076087;Note=Phosphorylated CTD-interacting factor 1
PCIF1	Q9H4Z3	274	301	1	704	Chain	ID=PRO_0000076087;Note=Phosphorylated CTD-interacting factor 1
PCIF1	Q9H4Z3	83	129	109	113	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
PCIF1	Q9H4Z3	83	129	116	116	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163
PER1	O15534	739	820	1	1290	Chain	ID=PRO_0000162627;Note=Period circadian protein homolog 1
PER1	O15534	679	739	1	1290	Chain	ID=PRO_0000162627;Note=Period circadian protein homolog 1
PER1	O15534	92	124	1	1290	Chain	ID=PRO_0000162627;Note=Period circadian protein homolog 1
PER1	O15534	92	124	1	151	Region	Note=Interaction with BTRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222
PER1	O15534	739	820	596	815	Region	Note=Required for phosphorylation by CSNK1E;Ontology_term=ECO:0000250;evidence=ECO:0000250
PER1	O15534	679	739	596	815	Region	Note=Required for phosphorylation by CSNK1E;Ontology_term=ECO:0000250;evidence=ECO:0000250
PER1	O15534	92	124	49	129	Compositional bias	Note=Ser-rich
PER1	O15534	92	124	121	121	Modified residue	Note=Phosphothreonine%3B by CSNK1E;Ontology_term=ECO:0000255;evidence=ECO:0000255
PER1	O15534	92	124	122	122	Modified residue	Note=Phosphoserine%3B by CSNK1E;Ontology_term=ECO:0000255;evidence=ECO:0000255
PER1	O15534	679	739	704	704	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
PER1	O15534	739	820	815	815	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
PER1	O15534	679	739	696	696	Natural variant	ID=VAR_036038;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
PER1	O15534	92	124	121	126	Mutagenesis	Note=Strongly decreases interaction with BTRC and FBXW11 and inhibits degradation promoted by CSNK1E. TSGCSS->AAGCSA
PER1	O15534	679	739	714	726	Mutagenesis	Note=No effect on interaction with BTRC and FBXW11. SVVSVTSQCSFSS->AVVAVTAQCAFAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222
PER1	O15534	739	820	794	798	Mutagenesis	Note=Strongly decreases interaction with BTRC and FBXW11. FLSRF->ALSRA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222
PER2	O15055	472	514	1	1255	Chain	ID=PRO_0000162630;Note=Period circadian protein homolog 2
PER2	O15055	472	514	480	484	Region	Note=Important for protein stability;Ontology_term=ECO:0000250;evidence=ECO:0000250
PER2	O15055	472	514	510	513	Compositional bias	Note=Poly-Arg
PER2	O15055	472	514	405	1255	Alternative sequence	ID=VSP_021654;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
PINK1	Q9BXM7	259	319	78	581	Chain	ID=PRO_0000024369;Note=Serine/threonine-protein kinase PINK1%2C mitochondrial
PINK1	Q9BXM7	417	496	78	581	Chain	ID=PRO_0000024369;Note=Serine/threonine-protein kinase PINK1%2C mitochondrial
PINK1	Q9BXM7	259	319	111	581	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PINK1	Q9BXM7	417	496	111	581	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PINK1	Q9BXM7	259	319	156	511	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000305
PINK1	Q9BXM7	417	496	156	511	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000305
PINK1	Q9BXM7	259	319	1	307	Alternative sequence	ID=VSP_050754;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PINK1	Q9BXM7	259	319	308	320	Alternative sequence	ID=VSP_050755;Note=In isoform 2. LGHGRTLFLVMKN->MCGSQRPSPLSTS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PINK1	Q9BXM7	259	319	263	263	Natural variant	ID=VAR_046583;Note=R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=PMID:15596610
PINK1	Q9BXM7	259	319	268	268	Natural variant	ID=VAR_046584;Note=In PARK6. L->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16207217,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs372280083,PMID:16207217,PMID:18330912
PINK1	Q9BXM7	259	319	271	271	Natural variant	ID=VAR_046585;Note=In PARK6. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15349870;Dbxref=dbSNP:rs28940284,PMID:15349870
PINK1	Q9BXM7	259	319	276	276	Natural variant	ID=VAR_046586;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs548506734,PMID:18330912
PINK1	Q9BXM7	259	319	279	279	Natural variant	ID=VAR_046587;Note=In PARK6. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15970950;Dbxref=dbSNP:rs74315358,PMID:15970950
PINK1	Q9BXM7	259	319	280	280	Natural variant	ID=VAR_062774;Note=In PARK6%3B early-onset. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16482571;Dbxref=dbSNP:rs772510148,PMID:16482571
PINK1	Q9BXM7	259	319	296	296	Natural variant	ID=VAR_046588;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15349860,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs779060308,PMID:15349860,PMID:18330912
PINK1	Q9BXM7	259	319	305	305	Natural variant	ID=VAR_018993;Note=P->L;Dbxref=dbSNP:rs7349186
PINK1	Q9BXM7	259	319	309	309	Natural variant	ID=VAR_018994;Note=In PARK6%3B fails to maintain mitochondrial membrane potential%3B full-length mutant has no effect on autophosphorylation%3B strongly reduces interaction with PRKN%3B decreases PRKN and SNCAIP ubiquitination and degradation. G->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15087508,ECO:0000269|PubMed:16207731,ECO:0000269|PubMed:19229105,ECO:0000269|PubMed:20798600;Dbxref=dbSNP:rs74315355,PMID:15087508,PMID:16207731,PMID:19229105,PMID:20798600
PINK1	Q9BXM7	259	319	313	313	Natural variant	ID=VAR_046589;Note=In PARK6%3B decreases PRKN and SNCAIP ubiquitination and degradation. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17030667,ECO:0000269|PubMed:19229105;Dbxref=dbSNP:rs74315359,PMID:17030667,PMID:19229105
PINK1	Q9BXM7	259	319	317	317	Natural variant	ID=VAR_046590;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16969854,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs200949139,PMID:16969854,PMID:18330912
PINK1	Q9BXM7	259	319	318	318	Natural variant	ID=VAR_046591;Note=M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=dbSNP:rs139226733,PMID:15596610
PINK1	Q9BXM7	417	496	417	417	Natural variant	ID=VAR_046599;Note=In PARK6. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15349870;Dbxref=PMID:15349870
PINK1	Q9BXM7	417	496	425	425	Natural variant	ID=VAR_046600;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=dbSNP:rs554114655,PMID:15596610
PINK1	Q9BXM7	417	496	431	431	Natural variant	ID=VAR_046601;Note=May predispose to Parkinson disease development%3B shows decreased mitochondrial membrane potential under stress conditions. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16969854;Dbxref=dbSNP:rs74315361,PMID:16969854
PINK1	Q9BXM7	417	496	442	442	Natural variant	ID=VAR_046602;Note=I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15349860,ECO:0000269|PubMed:18330912;Dbxref=PMID:15349860,PMID:18330912
PINK1	Q9BXM7	417	496	451	451	Natural variant	ID=VAR_046603;Note=May predispose to Parkinson disease development%3B shows decreased mitochondrial membrane potential under stress conditions. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16969854;Dbxref=dbSNP:rs747400197,PMID:16969854
PINK1	Q9BXM7	417	496	456	581	Natural variant	ID=VAR_078935;Note=In PARK6. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24652937;Dbxref=PMID:24652937
PINK1	Q9BXM7	417	496	461	461	Natural variant	ID=VAR_046604;Note=L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16969854;Dbxref=PMID:16969854
PINK1	Q9BXM7	417	496	464	464	Natural variant	ID=VAR_046605;Note=In PARK6. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15349860;Dbxref=dbSNP:rs764328076,PMID:15349860
PINK1	Q9BXM7	417	496	476	476	Natural variant	ID=VAR_046606;Note=May predispose to Parkinson disease development%3B shows decreased mitochondrial membrane potential under stress conditions. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15349860,ECO:0000269|PubMed:15596610,ECO:0000269|PubMed:16009891,ECO:0000269|PubMed:16969854,ECO:0000269|PubMed:18330912;Dbxref=dbSNP:rs115477764,PMID:15349860,PMID:15596610,PMID:16009891,PMID:16969854,PMID:18330912
PINK1	Q9BXM7	417	496	477	477	Natural variant	ID=VAR_041017;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34416410,PMID:17344846
PINK1	Q9BXM7	417	496	489	489	Natural variant	ID=VAR_046607;Note=In PARK6. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15596610;Dbxref=PMID:15596610
PINK1	Q9BXM7	417	496	419	419	Sequence conflict	Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
PIWIL4	Q7Z3Z4	55	99	1	852	Chain	ID=PRO_0000234572;Note=Piwi-like protein 4
PIWIL4	Q7Z3Z4	55	99	1	69	Alternative sequence	ID=VSP_036665;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PIWIL4	Q7Z3Z4	55	99	78	78	Natural variant	ID=VAR_028367;Note=Q->R;Dbxref=dbSNP:rs12276921
PIWIL4	Q7Z3Z4	55	99	99	99	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
PLD1	Q13393	864	909	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	584	622	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	446	513	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	180	202	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	253	303	1	1074	Chain	ID=PRO_0000218802;Note=Phospholipase D1
PLD1	Q13393	180	202	81	212	Domain	Note=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
PLD1	Q13393	253	303	219	328	Domain	Note=PH
PLD1	Q13393	446	513	459	486	Domain	Note=PLD phosphodiesterase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00153
PLD1	Q13393	864	909	891	918	Domain	Note=PLD phosphodiesterase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00153
PLD1	Q13393	864	909	463	928	Region	Note=Catalytic
PLD1	Q13393	584	622	463	928	Region	Note=Catalytic
PLD1	Q13393	446	513	463	928	Region	Note=Catalytic
PLD1	Q13393	446	513	499	499	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70496
PLD1	Q13393	584	622	514	597	Alternative sequence	ID=VSP_005018;Note=In isoform PLD1C. PAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLI->IPGPSVVYRQVWESCMGKPDSGMERTTAISSSKTGFNLINLLLISLTGTPRPGCPGMTLPLQSTGRRLVMWHVTSSSAGTSQKL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD1	Q13393	584	622	585	623	Alternative sequence	ID=VSP_005020;Note=In isoform PLD1B. SYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHAD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9013646,ECO:0000303|PubMed:9761774;Dbxref=PMID:9013646,PMID:9761774
PLD1	Q13393	864	909	598	1074	Alternative sequence	ID=VSP_005019;Note=In isoform PLD1C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD1	Q13393	584	622	598	1074	Alternative sequence	ID=VSP_005019;Note=In isoform PLD1C. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9761774;Dbxref=PMID:9761774
PLD1	Q13393	584	622	622	622	Natural variant	ID=VAR_022056;Note=A->S;Dbxref=dbSNP:rs2290480
PLEKHN1	Q494U1	384	431	2	611	Chain	ID=PRO_0000309363;Note=Pleckstrin homology domain-containing family N member 1
PLEKHN1	Q494U1	431	478	2	611	Chain	ID=PRO_0000309363;Note=Pleckstrin homology domain-containing family N member 1
PLEKHN1	Q494U1	431	478	456	456	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18191643;Dbxref=PMID:18191643
PLEKHN1	Q494U1	384	431	385	431	Alternative sequence	ID=VSP_059840;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHN1	Q494U1	431	478	385	431	Alternative sequence	ID=VSP_059840;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
PLEKHN1	Q494U1	431	478	456	456	Mutagenesis	Note=Loss of phosphorylation and interaction with C1QBP%3B when associated with F-302. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18191643;Dbxref=PMID:18191643
PLXNB2	O15031	696	727	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	1414	1463	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	662	696	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	696	727	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	1414	1463	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	662	696	20	1838	Chain	ID=PRO_0000024673;Note=Plexin-B2
PLXNB2	O15031	696	727	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	662	696	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	696	727	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	662	696	20	1197	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	1414	1463	1219	1838	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	1414	1463	1219	1838	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
PLXNB2	O15031	1414	1463	1462	1469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E71
PLXNB2	O15031	1414	1463	1462	1469	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4E71
PNPT1	Q8TCS8	716	732	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	172	188	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	480	498	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	534	558	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	607	635	46	783	Chain	ID=PRO_0000024751;Note=Polyribonucleotide nucleotidyltransferase 1%2C mitochondrial
PNPT1	Q8TCS8	607	635	605	664	Domain	Note=KH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117
PNPT1	Q8TCS8	716	732	679	750	Domain	Note=S1 motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00180
PNPT1	Q8TCS8	534	558	552	552	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8K1R3
PNPT1	Q8TCS8	480	498	484	484	Mutagenesis	Note=Inhibits poly(A) polymerase and RNA degradation activities. Does not inhibit the import or stabilization of RNase P RNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904
PNPT1	Q8TCS8	534	558	544	544	Mutagenesis	Note=Stimulates in vitro poly(A) polymerase activity. Inhibits RNA degradation activity. Inhibits the import or stabilization of RNase P RNA into the mitochondrial matrix. Does not inhibit homotrimerization activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20691904;Dbxref=PMID:20691904
PNPT1	Q8TCS8	172	188	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	172	188	180	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	480	498	483	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	534	558	535	539	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	534	558	541	549	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	534	558	554	561	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	606	611	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	614	621	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	623	625	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
PNPT1	Q8TCS8	607	635	626	635	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3U1K
POLR2D	O15514	85	116	1	142	Chain	ID=PRO_0000073981;Note=DNA-directed RNA polymerase II subunit RPB4
POLR2D	O15514	85	116	77	88	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2D	O15514	85	116	94	103	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2D	O15514	85	116	108	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2D	O15514	85	116	116	118	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2G	P62487	133	157	1	172	Chain	ID=PRO_0000073986;Note=DNA-directed RNA polymerase II subunit RPB7
POLR2G	P62487	133	157	151	151	Mutagenesis	Note=Strongly reduces RNA-binding. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16282592;Dbxref=PMID:16282592
POLR2G	P62487	133	157	153	153	Mutagenesis	Note=Strongly reduces RNA-binding. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16282592;Dbxref=PMID:16282592
POLR2G	P62487	133	157	135	138	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2G	P62487	133	157	142	153	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
POLR2G	P62487	133	157	156	162	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2C35
PPP1CA	P62136	18	62	2	330	Chain	ID=PRO_0000058774;Note=Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
PPP1CA	P62136	139	174	2	330	Chain	ID=PRO_0000058774;Note=Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
PPP1CA	P62136	62	139	2	330	Chain	ID=PRO_0000058774;Note=Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
PPP1CA	P62136	62	139	125	125	Active site	Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	64	64	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	66	66	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	92	92	Metal binding	Note=Manganese
PPP1CA	P62136	62	139	92	92	Metal binding	Note=Manganese 1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	92	92	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	62	139	124	124	Metal binding	Note=Manganese
PPP1CA	P62136	62	139	124	124	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	139	174	173	173	Metal binding	Note=Manganese
PPP1CA	P62136	139	174	173	173	Metal binding	Note=Manganese 2;Ontology_term=ECO:0000250;evidence=ECO:0000250
PPP1CA	P62136	18	62	22	22	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
PPP1CA	P62136	18	62	18	18	Alternative sequence	ID=VSP_043377;Note=In isoform 2. E->EGSRVLTPHCAP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8384581;Dbxref=PMID:8384581
PPP1CA	P62136	18	62	19	62	Alternative sequence	ID=VSP_046754;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1CA	P62136	62	139	19	62	Alternative sequence	ID=VSP_046754;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
PPP1CA	P62136	18	62	9	18	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	19	21	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	32	48	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	51	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	18	62	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	57	62	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	69	79	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	87	89	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	94	98	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	100	113	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	115	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	118	120	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	124	126	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6ALZ
PPP1CA	P62136	62	139	128	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	136	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	62	139	136	143	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	146	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	162	165	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	166	168	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PPP1CA	P62136	139	174	169	171	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4MOV
PTCD3	Q96EY7	607	659	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
PTCD3	Q96EY7	365	382	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
PTCD3	Q96EY7	382	412	38	689	Chain	ID=PRO_0000305028;Note=Pentatricopeptide repeat domain-containing protein 3%2C mitochondrial
PTCD3	Q96EY7	365	382	331	367	Repeat	Note=PPR 5
PTCD3	Q96EY7	365	382	368	409	Repeat	Note=PPR 6
PTCD3	Q96EY7	382	412	368	409	Repeat	Note=PPR 6
PTCD3	Q96EY7	382	412	412	446	Repeat	Note=PPR 7
PTCD3	Q96EY7	365	382	1	409	Alternative sequence	ID=VSP_028191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTCD3	Q96EY7	382	412	1	409	Alternative sequence	ID=VSP_028191;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTCD3	Q96EY7	382	412	410	413	Alternative sequence	ID=VSP_028192;Note=In isoform 2. PDDD->MMAY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
PTCD3	Q96EY7	382	412	400	400	Sequence conflict	Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2B	Q14289	738	780	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	911	938	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	829	841	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	295	329	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	738	780	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	911	938	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	829	841	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	295	329	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
PTK2B	Q14289	295	329	39	359	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2B	Q14289	295	329	39	359	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00084
PTK2B	Q14289	911	938	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	829	841	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	911	938	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	829	841	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
PTK2B	Q14289	911	938	868	1009	Region	Note=Focal adhesion targeting (FAT)
PTK2B	Q14289	911	938	868	1009	Region	Note=Focal adhesion targeting (FAT)
PTK2B	Q14289	738	780	702	767	Compositional bias	Note=Pro-rich
PTK2B	Q14289	738	780	702	767	Compositional bias	Note=Pro-rich
PTK2B	Q14289	829	841	831	869	Compositional bias	Note=Pro-rich
PTK2B	Q14289	829	841	831	869	Compositional bias	Note=Pro-rich
PTK2B	Q14289	738	780	762	762	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	738	780	762	762	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	738	780	765	765	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
PTK2B	Q14289	738	780	765	765	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
PTK2B	Q14289	829	841	834	834	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	829	841	834	834	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19369195;Dbxref=PMID:19369195
PTK2B	Q14289	829	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PTK2B	Q14289	829	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
PTK2B	Q14289	738	780	739	780	Alternative sequence	ID=VSP_004981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9545257;Dbxref=PMID:9545257
PTK2B	Q14289	738	780	739	780	Alternative sequence	ID=VSP_004981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9545257;Dbxref=PMID:9545257
PTK2B	Q14289	829	841	838	838	Natural variant	ID=VAR_020284;Note=K->T;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs751019,PMID:19369195,PMID:17344846
PTK2B	Q14289	829	841	838	838	Natural variant	ID=VAR_020284;Note=K->T;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19369195,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs751019,PMID:19369195,PMID:17344846
PTK2B	Q14289	738	780	780	780	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2B	Q14289	738	780	780	780	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
PTK2B	Q14289	295	329	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	314	316	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	314	316	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	317	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	295	329	317	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4EKU
PTK2B	Q14289	911	938	906	927	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	906	927	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	933	962	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PTK2B	Q14289	911	938	933	962	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4XEK
PUM1	Q14671	121	144	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	950	996	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	996	1038	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	548	596	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	417	451	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	695	774	2	1186	Chain	ID=PRO_0000075917;Note=Pumilio homolog 1
PUM1	Q14671	950	996	828	1168	Domain	Note=PUM-HD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00318
PUM1	Q14671	996	1038	828	1168	Domain	Note=PUM-HD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00318
PUM1	Q14671	950	996	920	955	Repeat	Note=Pumilio 3;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	950	996	956	991	Repeat	Note=Pumilio 4;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	950	996	992	1027	Repeat	Note=Pumilio 5;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	996	1038	992	1027	Repeat	Note=Pumilio 5;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	996	1038	1028	1063	Repeat	Note=Pumilio 6;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00317,ECO:0000269|PubMed:21397187;Dbxref=PMID:21397187
PUM1	Q14671	950	996	971	975	Region	Note=Non-specific-nucleotide binding in RNA target;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18328718;Dbxref=PMID:18328718
PUM1	Q14671	996	1038	1007	1011	Region	Note=Adenine-nucleotide binding in RNA target;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18328718;Dbxref=PMID:18328718
PUM1	Q14671	548	596	393	613	Compositional bias	Note=Ala-rich
PUM1	Q14671	417	451	393	613	Compositional bias	Note=Ala-rich
PUM1	Q14671	695	774	642	815	Compositional bias	Note=Ser-rich
PUM1	Q14671	121	144	124	124	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569
PUM1	Q14671	695	774	709	709	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
PUM1	Q14671	695	774	714	714	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20818387;Dbxref=PMID:20818387
PUM1	Q14671	417	451	417	417	Alternative sequence	ID=VSP_017059;Note=In isoform 2 and isoform 4. I->IA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7788527;Dbxref=PMID:14702039,PMID:7788527
PUM1	Q14671	950	996	950	950	Alternative sequence	ID=VSP_017061;Note=In isoform 2 and isoform 3. Q->QVI;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7788527,ECO:0000303|Ref.4;Dbxref=PMID:7788527
PUM1	Q14671	996	1038	1033	1033	Natural variant	ID=VAR_080784;Note=In SCA47%3B results in reduced PUM1 protein levels and decreased post-transcriptional repression of E2F3 and ATXN1. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29474920;Dbxref=PMID:29474920
PUM1	Q14671	695	774	714	714	Mutagenesis	Note=Decreased RNA-binding activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20818387;Dbxref=PMID:20818387
PUM1	Q14671	695	774	714	714	Mutagenesis	Note=Phospho-mimic mutant%3B persistent RNA-binding activity in quiescent cells. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20818387;Dbxref=PMID:20818387
PUM1	Q14671	950	996	971	975	Mutagenesis	Note=Specifically binds cytosine-nucleotide in RNA target. NHVVQ->GHVVR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	996	1038	1007	1011	Mutagenesis	Note=Specifically binds cytosine-nucleotide in RNA target. CRVIQ->GRVIR%2CARVIR%2CSRVIR%2CTRVIR%2CCRVIR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	996	1038	1007	1011	Mutagenesis	Note=Specifically binds guanine-nucleotide in RNA target. CRVIQ->SRVIE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	996	1038	1007	1007	Mutagenesis	Note=Specifically binds uracil-nucleotide in RNA target. C->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21572425;Dbxref=PMID:21572425
PUM1	Q14671	950	996	947	954	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	955	957	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	961	966	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	970	980	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	983	986	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	987	992	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	950	996	993	996	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	993	996	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	997	1001	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	1006	1016	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	1019	1031	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUM1	Q14671	996	1038	1033	1036	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1IB2
PUS7	Q96PZ0	307	349	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	161	195	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	508	542	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	307	349	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	161	195	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	508	542	1	661	Chain	ID=PRO_0000152558;Note=Pseudouridylate synthase 7 homolog
PUS7	Q96PZ0	508	542	370	580	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7	Q96PZ0	508	542	370	580	Domain	Note=TRUD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00342
PUS7	Q96PZ0	161	195	166	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	161	195	166	177	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	161	195	192	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	161	195	192	195	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	310	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	310	315	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	316	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	316	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	321	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	321	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	342	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	307	349	342	351	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	510	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	510	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	516	518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	516	518	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	519	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	519	521	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	524	526	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	524	526	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	527	531	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	527	531	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	533	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
PUS7	Q96PZ0	508	542	533	535	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5KKP
RARS2	Q5T160	71	99	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	150	178	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	204	257	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	504	528	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	472	503	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	293	324	17	578	Chain	ID=PRO_0000250731;Note=Probable arginine--tRNA ligase%2C mitochondrial
RARS2	Q5T160	293	324	322	322	Binding site	Note=L-arginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54136
RC3H1	Q5TC82	987	1045	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	790	841	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	445	538	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	987	1045	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	790	841	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	445	538	1	1133	Chain	ID=PRO_0000055965;Note=Roquin-1
RC3H1	Q5TC82	445	538	533	788	Compositional bias	Note=Pro-rich
RC3H1	Q5TC82	445	538	533	788	Compositional bias	Note=Pro-rich
RC3H1	Q5TC82	445	538	510	510	Site	Note=Cleavage%3B by MALT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	510	510	Site	Note=Cleavage%3B by MALT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	462	462	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RC3H1	Q5TC82	445	538	462	462	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
RC3H1	Q5TC82	445	538	531	531	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	531	531	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q4VGL6
RC3H1	Q5TC82	445	538	535	535	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
RC3H1	Q5TC82	445	538	535	535	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
RC3H1	Q5TC82	987	1045	988	996	Alternative sequence	ID=VSP_015015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RC3H1	Q5TC82	987	1045	988	996	Alternative sequence	ID=VSP_015015;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ROCK1	Q13464	92	138	2	1354	Chain	ID=PRO_0000086619;Note=Rho-associated protein kinase 1
ROCK1	Q13464	92	138	76	338	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK1	Q13464	92	138	105	105	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK1	Q13464	92	138	108	108	Natural variant	ID=VAR_041055;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55811609,PMID:17344846
ROCK1	Q13464	92	138	86	95	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	96	98	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	101	108	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	109	114	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK1	Q13464	92	138	121	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3V8S
ROCK2	O75116	108	154	1	1388	Chain	ID=PRO_0000086625;Note=Rho-associated protein kinase 2
ROCK2	O75116	154	241	1	1388	Chain	ID=PRO_0000086625;Note=Rho-associated protein kinase 2
ROCK2	O75116	108	154	92	354	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK2	O75116	154	241	92	354	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK2	O75116	154	241	214	214	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
ROCK2	O75116	108	154	121	121	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
ROCK2	O75116	108	154	102	111	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	112	114	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	117	124	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	125	130	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	108	154	138	146	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	155	160	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	162	169	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	177	183	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	188	207	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	217	219	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	220	222	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	228	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
ROCK2	O75116	154	241	241	246	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q
RPL10	P27635	27	63	2	214	Chain	ID=PRO_0000147105;Note=60S ribosomal protein L10
RPL10	P27635	27	63	2	214	Chain	ID=PRO_0000147105;Note=60S ribosomal protein L10
RPL10	P27635	27	63	32	32	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL10	P27635	27	63	32	32	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL10	P27635	27	63	43	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	43	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	58	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	58	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	62	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10	P27635	27	63	62	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2
RPL10A	P62906	27	53	2	217	Chain	ID=PRO_0000125818;Note=60S ribosomal protein L10a
RPL12	P30050	97	126	1	165	Chain	ID=PRO_0000104456;Note=60S ribosomal protein L12
RPL12	P30050	37	70	1	165	Chain	ID=PRO_0000104456;Note=60S ribosomal protein L12
RPL12	P30050	37	70	38	38	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163
RPL12	P30050	37	70	54	54	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL12	P30050	37	70	40	40	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL12	P30050	37	70	38	70	Alternative sequence	ID=VSP_034695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPL13	P26373	140	159	1	211	Chain	ID=PRO_0000192919;Note=60S ribosomal protein L13
RPL13	P26373	140	159	1	211	Chain	ID=PRO_0000192919;Note=60S ribosomal protein L13
RPL13	P26373	140	159	1	211	Chain	ID=PRO_0000192919;Note=60S ribosomal protein L13
RPL13	P26373	140	159	145	145	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL13	P26373	140	159	145	145	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL13	P26373	140	159	145	145	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL13A	P40429	51	85	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	134	175	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	114	134	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	29	51	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
RPL13A	P40429	51	85	59	59	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL13A	P40429	51	85	77	77	Modified residue	Note=Phosphoserine%3B by ZIPK/DAPK3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18995835;Dbxref=PMID:18995835
RPL13A	P40429	134	175	140	140	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL13A	P40429	51	85	77	77	Mutagenesis	Note=Loss of interferon-gamma induced phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18995835;Dbxref=PMID:18995835
RPL18	Q07020	1	30	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12962325;Dbxref=PMID:12962325
RPL18	Q07020	1	30	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
RPL18	Q07020	30	66	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
RPL18	Q07020	66	99	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
RPL18	Q07020	1	30	1	30	Alternative sequence	ID=VSP_055170;Note=In isoform 2. MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL18	Q07020	30	66	1	30	Alternative sequence	ID=VSP_055170;Note=In isoform 2. MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL18	Q07020	30	66	62	62	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL19	P84098	119	155	1	196	Chain	ID=PRO_0000131169;Note=60S ribosomal protein L19
RPL19	P84098	37	78	1	196	Chain	ID=PRO_0000131169;Note=60S ribosomal protein L19
RPL19	P84098	37	78	38	38	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL22	P35268	4	39	2	128	Chain	ID=PRO_0000215501;Note=60S ribosomal protein L22
RPL23	P62829	75	113	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	32	75	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	75	113	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	32	75	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	4	32	1	140	Chain	ID=PRO_0000128612;Note=60S ribosomal protein L23
RPL23	P62829	4	32	17	17	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
RPL23	P62829	32	75	38	38	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
RPL23	P62829	32	75	38	38	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
RPL23	P62829	75	113	77	77	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL23	P62829	75	113	77	77	Sequence conflict	Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL23A	P62750	70	128	2	156	Chain	ID=PRO_0000129467;Note=60S ribosomal protein L23a
RPL23A	P62750	70	128	70	70	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62751
RPL23A	P62750	70	128	99	99	Natural variant	ID=VAR_069221;Note=Rare variant found in Diamond-Blackfan anemia patients%3B unknown pathological significance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22431104;Dbxref=dbSNP:rs151327030,PMID:22431104
RPL23A	P62750	70	128	78	78	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL23A	P62750	70	128	110	110	Sequence conflict	Note=K->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL24	P83731	27	64	1	157	Chain	ID=PRO_0000136867;Note=60S ribosomal protein L24
RPL24	P83731	27	64	27	27	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL24	P83731	27	64	27	27	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL24	P83731	27	64	35	35	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RPL26L1	Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
RPL3	P39023	283	317	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
RPL3	P39023	349	389	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
RPL3	P39023	317	349	2	403	Chain	ID=PRO_0000077227;Note=60S ribosomal protein L3
RPL3	P39023	283	317	286	286	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27659
RPL3	P39023	283	317	294	294	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL3	P39023	283	317	304	304	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
RPL3	P39023	349	389	366	366	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL3	P39023	349	389	373	373	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27659
RPL3	P39023	283	317	286	286	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL3	P39023	283	317	294	294	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
RPL3	P39023	349	389	366	366	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL3	P39023	349	389	386	386	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL31	P62899	36	77	1	125	Chain	ID=PRO_0000153763;Note=60S ribosomal protein L31
RPL31	P62899	36	77	1	125	Chain	ID=PRO_0000153763;Note=60S ribosomal protein L31
RPL31	P62899	36	77	55	55	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	55	55	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	70	70	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	70	70	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL31	P62899	36	77	75	75	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P62900
RPL35A	P18077	4	54	1	110	Chain	ID=PRO_0000192796;Note=60S ribosomal protein L35a
RPL35A	P18077	4	54	1	110	Chain	ID=PRO_0000192796;Note=60S ribosomal protein L35a
RPL35A	P18077	4	54	8	8	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL35A	P18077	4	54	8	8	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL35A	P18077	4	54	27	27	Natural variant	ID=VAR_055446;Note=In DBA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=PMID:18535205
RPL35A	P18077	4	54	27	27	Natural variant	ID=VAR_055446;Note=In DBA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=PMID:18535205
RPL35A	P18077	4	54	33	33	Natural variant	ID=VAR_055447;Note=In DBA5%3B may result in aberrant splicing. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=dbSNP:rs116840808,PMID:18535205
RPL35A	P18077	4	54	33	33	Natural variant	ID=VAR_055447;Note=In DBA5%3B may result in aberrant splicing. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18535205;Dbxref=dbSNP:rs116840808,PMID:18535205
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	2	105	Chain	ID=PRO_0000195007;Note=60S ribosomal protein L36
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	62	62	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL36	Q9Y3U8	31	76	67	67	Natural variant	ID=VAR_051804;Note=K->E;Dbxref=dbSNP:rs11556110
RPL38	P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
RPL38	P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
RPL38	P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
RPL4	P36578	278	305	2	427	Chain	ID=PRO_0000129350;Note=60S ribosomal protein L4
RPL4	P36578	278	305	290	290	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P50878
RPL4	P36578	278	305	295	295	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18691976,PMID:20068231,PMID:23186163
RPL4	P36578	278	305	300	300	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPL5	P46777	63	108	2	297	Chain	ID=PRO_0000131431;Note=60S ribosomal protein L5
RPL5	P46777	63	108	78	78	Sequence conflict	Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPL6	Q02878	79	112	2	288	Chain	ID=PRO_0000171009;Note=60S ribosomal protein L6
RPL6	Q02878	79	112	2	288	Chain	ID=PRO_0000171009;Note=60S ribosomal protein L6
RPL6	Q02878	79	112	94	94	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47911
RPL6	Q02878	79	112	94	94	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P47911
RPL6	Q02878	79	112	100	100	Natural variant	ID=VAR_036437;Note=In a colorectal cancer sample%3B somatic mutation. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
RPL6	Q02878	79	112	100	100	Natural variant	ID=VAR_036437;Note=In a colorectal cancer sample%3B somatic mutation. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974
RPL7	P18124	97	142	1	248	Chain	ID=PRO_0000104633;Note=60S ribosomal protein L7
RPL7	P18124	97	142	124	124	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL7	P18124	97	142	127	127	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14148
RPL7	P18124	97	142	139	139	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
RPL7A	P62424	41	91	1	266	Chain	ID=PRO_0000136747;Note=60S ribosomal protein L7a
RPL7A	P62424	91	138	1	266	Chain	ID=PRO_0000136747;Note=60S ribosomal protein L7a
RPL7A	P62424	91	138	97	97	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPL7A	P62424	41	91	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL7A	P62424	91	138	97	97	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL7A	P62424	91	138	125	125	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL8	P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
RPL8	P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
RPL8	P62917	93	166	2	257	Chain	ID=PRO_0000129743;Note=60S ribosomal protein L8
RPL8	P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL8	P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL8	P62917	93	166	149	149	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPL8	P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
RPL8	P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
RPL8	P62917	93	166	98	98	Natural variant	ID=VAR_019658;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs11539893,PMID:15489334
RPLP0	P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
RPLP0	P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPLP0	P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPLP0	P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPLP0	P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPLP2	P05387	57	90	1	115	Chain	ID=PRO_0000157640;Note=60S acidic ribosomal protein P2
RPLP2	P05387	57	90	1	115	Chain	ID=PRO_0000157640;Note=60S acidic ribosomal protein P2
RPLP2	P05387	57	90	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:24275569
RPLP2	P05387	57	90	79	79	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:24275569
RPLP2	P05387	57	90	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
RPLP2	P05387	57	90	86	86	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569
RPLP2	P05387	57	90	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBF
RPLP2	P05387	57	90	59	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LBF
RPLP2	P05387	57	90	63	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BEH
RPLP2	P05387	57	90	63	66	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BEH
RPS11	P62280	5	49	2	158	Chain	ID=PRO_0000128509;Note=40S ribosomal protein S11
RPS11	P62280	5	49	22	22	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPS11	P62280	5	49	38	38	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS11	P62280	5	49	45	45	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS12	P25398	5	43	2	132	Chain	ID=PRO_0000122323;Note=40S ribosomal protein S12
RPS12	P25398	78	112	2	132	Chain	ID=PRO_0000122323;Note=40S ribosomal protein S12
RPS12	P25398	78	112	99	99	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS16	P62249	82	98	2	146	Chain	ID=PRO_0000111479;Note=40S ribosomal protein S16
RPS16	P62249	16	50	2	146	Chain	ID=PRO_0000111479;Note=40S ribosomal protein S16
RPS2	P15880	59	89	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
RPS2	P15880	125	183	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
RPS2	P15880	89	125	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
RPS2	P15880	125	183	102	165	Domain	Note=S5 DRBM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00268
RPS2	P15880	89	125	102	165	Domain	Note=S5 DRBM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00268
RPS21	P63220	38	62	1	83	Chain	ID=PRO_0000194730;Note=40S ribosomal protein S21
RPS21	P63220	38	62	41	41	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
RPS27	P42677	38	75	2	84	Chain	ID=PRO_0000149051;Note=40S ribosomal protein S27
RPS27	P42677	38	75	37	59	Zinc finger	Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255
RPS28	P62857	13	29	1	69	Chain	ID=PRO_0000136822;Note=40S ribosomal protein S28
RPS4X	P62701	1	27	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8706699;Dbxref=PMID:8706699
RPS4X	P62701	1	27	2	263	Chain	ID=PRO_0000130805;Note=40S ribosomal protein S4%2C X isoform
RPS5	P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
RPS5	P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
RPS5	P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS5	P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS5	P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
RPS5	P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS5	P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS5	P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS5	P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPS5	P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPS5	P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
RPS5	P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS5	P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS5	P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6	P62753	116	165	1	249	Chain	ID=PRO_0000137312;Note=40S ribosomal protein S6
RPS6	P62753	116	165	148	148	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
RPS6	P62753	116	165	144	144	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6	P62753	116	165	155	156	Sequence conflict	Note=QY->EC;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA3	P51812	42	81	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	108	135	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	534	588	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	481	534	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	451	481	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
RPS6KA3	P51812	42	81	68	327	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	108	135	68	327	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	534	588	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	481	534	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	451	481	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	42	81	74	82	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	534	588	539	539	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
RPS6KA3	P51812	451	481	451	451	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KA3	P51812	481	534	529	529	Modified residue	Note=Phosphotyrosine%3B by FGFR3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P18654
RPS6KA3	P51812	534	588	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18691976;Dbxref=PMID:18691976
RPS6KA3	P51812	42	81	75	75	Natural variant	ID=VAR_006189;Note=In CLS. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8955270;Dbxref=dbSNP:rs122454124,PMID:8955270
RPS6KA3	P51812	108	135	114	114	Natural variant	ID=VAR_006191;Note=In CLS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10094187;Dbxref=dbSNP:rs122454127,PMID:10094187
RPS6KA3	P51812	108	135	115	115	Natural variant	ID=VAR_065892;Note=In MRX19. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17100996;Dbxref=dbSNP:rs387906703,PMID:17100996
RPS6KA3	P51812	108	135	127	127	Natural variant	ID=VAR_006192;Note=In CLS. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9837815;Dbxref=PMID:9837815
RPS6KA3	P51812	451	481	477	477	Natural variant	ID=VAR_065898;Note=In CLS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15214012;Dbxref=PMID:15214012
RPS6KA3	P51812	481	534	483	483	Natural variant	ID=VAR_040629;Note=In a gastric adenocarcinoma sample%3B somatic mutation. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1271090915,PMID:17344846
RPS6KA3	P51812	451	481	480	480	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA3	P51812	481	534	494	494	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
RPS6KA3	P51812	42	81	50	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5D9L
RPS6KA3	P51812	42	81	65	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	42	81	68	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	42	81	78	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	108	135	109	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	108	135	133	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4NW6
RPS6KA3	P51812	451	481	446	454	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	451	481	455	457	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	451	481	461	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	451	481	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	486	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	501	506	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	481	534	513	532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	542	544	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	545	551	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	554	556	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	557	559	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KA3	P51812	534	588	571	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JG8
RPS6KA3	P51812	534	588	587	613	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4D9T
RPS6KB1	P23443	104	127	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
RPS6KB1	P23443	290	326	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
RPS6KB1	P23443	326	347	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
RPS6KB1	P23443	104	127	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	290	326	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	326	347	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	104	127	97	105	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	104	127	123	123	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB1	P23443	104	127	104	126	Alternative sequence	ID=VSP_055026;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS6KB1	P23443	104	127	101	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	104	127	114	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	104	127	119	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	104	127	127	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	290	326	298	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	290	326	314	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3A61
RPS6KB1	P23443	290	326	318	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	318	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	332	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	340	342	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB1	P23443	326	347	343	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3WF7
RPS6KB2	Q9UBS0	302	323	1	482	Chain	ID=PRO_0000086214;Note=Ribosomal protein S6 kinase beta-2
RPS6KB2	Q9UBS0	302	323	67	328	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
RPS6KB2	Q9UBS0	302	323	155	482	Alternative sequence	ID=VSP_056442;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RPS7	P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
RPS7	P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
RPS7	P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
RPUSD3	Q6P087	136	171	26	351	Chain	ID=PRO_0000300822;Note=Mitochondrial mRNA pseudouridine synthase RPUSD3
RPUSD3	Q6P087	87	102	26	351	Chain	ID=PRO_0000300822;Note=Mitochondrial mRNA pseudouridine synthase RPUSD3
RPUSD3	Q6P087	87	102	89	103	Alternative sequence	ID=VSP_027870;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
RPUSD3	Q6P087	136	171	137	351	Alternative sequence	ID=VSP_027869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
RWDD1	Q9H446	182	203	2	243	Chain	ID=PRO_0000097540;Note=RWD domain-containing protein 1
RWDD1	Q9H446	182	203	142	197	Region	Note=Interaction with DRG2;Ontology_term=ECO:0000250;evidence=ECO:0000250
SAMD4A	Q9UPU9	65	238	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	238	326	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	65	238	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	238	326	1	718	Chain	ID=PRO_0000097570;Note=Protein Smaug homolog 1
SAMD4A	Q9UPU9	238	326	323	391	Domain	Note=SAM
SAMD4A	Q9UPU9	238	326	323	391	Domain	Note=SAM
SAMD4A	Q9UPU9	65	238	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAMD4A	Q9UPU9	65	238	168	168	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SAMD4A	Q9UPU9	65	238	1	101	Alternative sequence	ID=VSP_037778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SAMD4A	Q9UPU9	65	238	1	101	Alternative sequence	ID=VSP_037778;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
SAMD4A	Q9UPU9	238	326	239	327	Alternative sequence	ID=VSP_037779;Note=In isoform 3. ILSGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASSGSGGSEHLEDQTTARNTFQEEGSGMKD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
SAMD4A	Q9UPU9	238	326	239	327	Alternative sequence	ID=VSP_037779;Note=In isoform 3. ILSGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASSGSGGSEHLEDQTTARNTFQEEGSGMKD->N;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
SAMD4A	Q9UPU9	65	238	108	108	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD4A	Q9UPU9	65	238	108	108	Sequence conflict	Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD4A	Q9UPU9	65	238	138	138	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SAMD4A	Q9UPU9	65	238	138	138	Sequence conflict	Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
SECISBP2	Q96T21	404	434	1	854	Chain	ID=PRO_0000097655;Note=Selenocysteine insertion sequence-binding protein 2
SECISBP2	Q96T21	404	434	428	428	Natural variant	ID=VAR_061704;Note=Q->E;Dbxref=dbSNP:rs45452691
SECISBP2L	Q93073	345	390	1	1101	Chain	ID=PRO_0000050739;Note=Selenocysteine insertion sequence-binding protein 2-like
SECISBP2L	Q93073	417	473	1	1101	Chain	ID=PRO_0000050739;Note=Selenocysteine insertion sequence-binding protein 2-like
SECISBP2L	Q93073	345	390	346	390	Alternative sequence	ID=VSP_016342;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9039502;Dbxref=PMID:9039502
SHMT1	P34896	310	351	1	483	Chain	ID=PRO_0000113504;Note=Serine hydroxymethyltransferase%2C cytosolic
SHMT1	P34896	271	310	1	483	Chain	ID=PRO_0000113504;Note=Serine hydroxymethyltransferase%2C cytosolic
SHMT1	P34896	310	351	273	352	Alternative sequence	ID=VSP_006096;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHMT1	P34896	271	310	273	352	Alternative sequence	ID=VSP_006096;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
SHMT1	P34896	310	351	274	312	Alternative sequence	ID=VSP_006095;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHMT1	P34896	271	310	274	312	Alternative sequence	ID=VSP_006095;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHMT1	P34896	310	351	340	340	Natural variant	ID=VAR_059795;Note=E->Q;Dbxref=dbSNP:rs7215148
SHMT1	P34896	271	310	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	278	280	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	283	285	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	288	296	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	297	300	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	310	351	306	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	271	310	306	318	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT1	P34896	310	351	322	344	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1BJ4
SHMT2	P34897	198	239	30	504	Chain	ID=PRO_0000032562;Note=Serine hydroxymethyltransferase%2C mitochondrial
SHMT2	P34897	198	239	199	208	Alternative sequence	ID=VSP_043088;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
SHMT2	P34897	198	239	199	201	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
SHMT2	P34897	198	239	202	204	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5V7I
SHMT2	P34897	198	239	206	216	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
SHMT2	P34897	198	239	219	223	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
SHMT2	P34897	198	239	234	244	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6DK3
SLBP	Q14493	94	113	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	160	209	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	59	93	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	20	58	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
SLBP	Q14493	160	209	129	198	Region	Note=RNA-binding
SLBP	Q14493	20	58	31	34	Motif	Note=Nuclear localization signal NLS1
SLBP	Q14493	94	113	96	99	Motif	Note=Nuclear localization signal NLS2
SLBP	Q14493	20	58	20	20	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
SLBP	Q14493	20	58	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
SLBP	Q14493	59	93	59	59	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
SLBP	Q14493	59	93	61	61	Modified residue	Note=Phosphothreonine%3B by CK2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
SLBP	Q14493	59	93	62	62	Modified residue	Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:23186163,PMID:12588979,PMID:18490441
SLBP	Q14493	160	209	171	171	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:23186163,ECO:0000269|PubMed:22439849;Dbxref=PMID:23186163,PMID:22439849
SLBP	Q14493	160	209	182	182	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
SLBP	Q14493	94	113	98	98	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
SLBP	Q14493	20	58	20	58	Alternative sequence	ID=VSP_042164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
SLBP	Q14493	20	58	31	34	Mutagenesis	Note=Reduces interaction with the importin alpha/importin beta receptor. Abolishes interaction with the importin alpha/importin beta receptor%3B when associated with A-96%3B A-97%3B A-98 and A-99 or with A-241%3B A-242%3B A-243 and A-244. RKRR->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15829567;Dbxref=PMID:15829567
SLBP	Q14493	59	93	59	63	Mutagenesis	Note=Does not increase its stability at the end of the S phase and through G2 and mitosis. SFTTP->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18490441;Dbxref=PMID:18490441
SLBP	Q14493	59	93	59	59	Mutagenesis	Note=Does not increase its stability at the end of the S phase and through G2 and mitosis. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12588979;Dbxref=PMID:12588979
SLBP	Q14493	59	93	61	61	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. Active in histone pre-mRNA processing during the G2 phase. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
SLBP	Q14493	59	93	62	62	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
SLBP	Q14493	59	93	63	63	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12588979;Dbxref=PMID:12588979
SLBP	Q14493	94	113	96	99	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. Inhibits phosphorylation of T-62. Localizes in the nucleus. Reduces interaction with the importin alpha/importin beta receptor. Abolishes interaction with the importin alpha/importin beta receptor%3B when associated with A-31%3B A-32%3B A-33 and A-34 or with A-241%3B A-242%3B A-243 and A-244. KRKL->AAAA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12588979,ECO:0000269|PubMed:15829567,ECO:0000269|PubMed:18490441;Dbxref=PMID:12588979,PMID:15829567,PMID:18490441
SLBP	Q14493	160	209	165	167	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QOZ
SLBP	Q14493	160	209	180	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QOZ
SLBP	Q14493	160	209	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4QOZ
SRBD1	Q8N5C6	470	505	1	995	Chain	ID=PRO_0000284357;Note=S1 RNA-binding domain-containing protein 1
STAT3	P40763	629	700	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	350	369	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	427	455	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	455	488	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	124	156	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	91	124	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	629	700	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	350	369	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	427	455	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	455	488	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	124	156	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	91	124	2	770	Chain	ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3
STAT3	P40763	629	700	580	670	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT3	P40763	629	700	580	670	Domain	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
STAT3	P40763	124	156	150	162	Motif	Note=Essential for nuclear import
STAT3	P40763	124	156	150	162	Motif	Note=Essential for nuclear import
STAT3	P40763	629	700	631	631	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	631	631	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	631	631	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	631	631	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=Allysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	629	700	685	685	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28065600;Dbxref=PMID:28065600
STAT3	P40763	124	156	143	143	Natural variant	ID=VAR_018679;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878478
STAT3	P40763	124	156	143	143	Natural variant	ID=VAR_018679;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878478
STAT3	P40763	427	455	437	437	Natural variant	ID=VAR_037372;Note=In AD-HIES%3B loss of function. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17676033;Dbxref=PMID:17676033
STAT3	P40763	427	455	437	437	Natural variant	ID=VAR_037372;Note=In AD-HIES%3B loss of function. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17676033;Dbxref=PMID:17676033
STAT3	P40763	455	488	463	463	Natural variant	ID=VAR_037373;Note=In AD-HIES%3B loss of function. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17676033,ECO:0000269|PubMed:17881745;Dbxref=PMID:17676033,PMID:17881745
STAT3	P40763	455	488	463	463	Natural variant	ID=VAR_037373;Note=In AD-HIES%3B loss of function. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17676033,ECO:0000269|PubMed:17881745;Dbxref=PMID:17676033,PMID:17881745
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037378;Note=In AD-HIES. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037378;Note=In AD-HIES. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037379;Note=In AD-HIES%3B reduced DNA-binding ability. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs113994139,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	637	637	Natural variant	ID=VAR_037379;Note=In AD-HIES%3B reduced DNA-binding ability. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs113994139,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	644	644	Natural variant	ID=VAR_037380;Note=In AD-HIES. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	644	644	Natural variant	ID=VAR_037380;Note=In AD-HIES. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17881745;Dbxref=PMID:17881745
STAT3	P40763	629	700	646	646	Natural variant	ID=VAR_071886;Note=In ADMIO1. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777649,PMID:25038750
STAT3	P40763	629	700	646	646	Natural variant	ID=VAR_071886;Note=In ADMIO1. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777649,PMID:25038750
STAT3	P40763	629	700	657	657	Natural variant	ID=VAR_037381;Note=In AD-HIES%3B reduced DNA-binding ability. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs193922721,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	657	657	Natural variant	ID=VAR_037381;Note=In AD-HIES%3B reduced DNA-binding ability. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17881745,ECO:0000269|PubMed:26293184;Dbxref=dbSNP:rs193922721,PMID:17881745,PMID:26293184
STAT3	P40763	629	700	658	658	Natural variant	ID=VAR_071887;Note=In ADMIO1. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777650,PMID:25038750
STAT3	P40763	629	700	658	658	Natural variant	ID=VAR_071887;Note=In ADMIO1. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25038750;Dbxref=dbSNP:rs587777650,PMID:25038750
STAT3	P40763	427	455	434	435	Mutagenesis	Note=Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. EE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344214,ECO:0000269|PubMed:25476455;Dbxref=PMID:17344214,PMID:25476455
STAT3	P40763	427	455	434	435	Mutagenesis	Note=Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. EE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344214,ECO:0000269|PubMed:25476455;Dbxref=PMID:17344214,PMID:25476455
STAT3	P40763	124	156	133	133	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	124	156	133	133	Sequence conflict	Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	455	488	460	460	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	455	488	460	460	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	652	652	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	652	652	Sequence conflict	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	667	667	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
STAT3	P40763	629	700	667	667	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TARS2	Q9BW92	258	307	211	340	Alternative sequence	ID=VSP_054537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TARS2	Q9BW92	307	340	211	340	Alternative sequence	ID=VSP_054537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TARS2	Q9BW92	258	307	282	282	Natural variant	ID=VAR_071853;Note=In COXPD21%3B decreased expression at mRNA and protein levels%3B decreased threonine-tRNA ligase activity%3B affects both Thr activation and transfer%3B decreased aminoacyl-tRNA editing activity%3B decreased protein stability%3B loss of homodimerization. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24827421,ECO:0000269|PubMed:26811336;Dbxref=dbSNP:rs587777593,PMID:24827421,PMID:26811336
TARS2	Q9BW92	258	307	269	269	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
TARS2	Q9BW92	573	606	579	579	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCOF1	Q13428	826	886	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	496	568	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1061	1099	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	213	290	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	290	361	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1261	1448	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	826	886	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	496	568	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1061	1099	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	213	290	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	290	361	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1260	1447	1	1488	Chain	ID=PRO_0000072459;Note=Treacle protein
TCOF1	Q13428	1261	1448	1362	1366	Compositional bias	Note=Poly-Lys
TCOF1	Q13428	1260	1447	1362	1366	Compositional bias	Note=Poly-Lys
TCOF1	Q13428	213	290	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
TCOF1	Q13428	213	290	233	233	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692
TCOF1	Q13428	213	290	249	249	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:19690332,PMID:20068231,PMID:23186163
TCOF1	Q13428	213	290	249	249	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:19690332,PMID:20068231,PMID:23186163
TCOF1	Q13428	290	361	296	296	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	290	361	296	296	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	290	361	310	310	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	290	361	310	310	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	290	361	313	313	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	290	361	313	313	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	290	361	316	316	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TCOF1	Q13428	290	361	316	316	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
TCOF1	Q13428	290	361	322	322	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	290	361	322	322	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08784
TCOF1	Q13428	496	568	503	503	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	496	568	503	503	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	496	568	533	533	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	496	568	533	533	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	826	886	868	868	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	868	868	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	870	870	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	870	870	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	871	871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	871	871	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	875	875	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	875	875	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	877	877	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	826	886	877	877	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231
TCOF1	Q13428	1261	1448	1350	1350	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TCOF1	Q13428	1260	1447	1350	1350	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
TCOF1	Q13428	1261	1448	1358	1358	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	1260	1447	1358	1358	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TCOF1	Q13428	1261	1448	1376	1376	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
TCOF1	Q13428	1260	1447	1376	1376	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
TCOF1	Q13428	1261	1448	1378	1378	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	1260	1447	1378	1378	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
TCOF1	Q13428	1261	1448	1407	1407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TCOF1	Q13428	1260	1447	1407	1407	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
TCOF1	Q13428	1261	1448	1410	1410	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TCOF1	Q13428	1260	1447	1410	1410	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
TCOF1	Q13428	1261	1448	1414	1414	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	1260	1447	1414	1414	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
TCOF1	Q13428	496	568	507	507	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TCOF1	Q13428	496	568	507	507	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
TCOF1	Q13428	1261	1448	1414	1414	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
TCOF1	Q13428	1260	1447	1414	1414	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:25772364,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:25772364,PMID:28112733
TCOF1	Q13428	213	290	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	290	361	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	213	290	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	290	361	214	290	Alternative sequence	ID=VSP_022295;Note=In isoform 2 and isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:8563749,ECO:0000303|PubMed:9074926;Dbxref=PMID:8563749,PMID:9074926
TCOF1	Q13428	1061	1099	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1261	1448	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1061	1099	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1260	1447	959	1488	Alternative sequence	ID=VSP_023134;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TCOF1	Q13428	1061	1099	1062	1099	Alternative sequence	ID=VSP_040382;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCOF1	Q13428	1061	1099	1062	1099	Alternative sequence	ID=VSP_040382;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TCOF1	Q13428	213	290	221	221	Natural variant	ID=VAR_057002;Note=A->P;Dbxref=dbSNP:rs11541811
TCOF1	Q13428	213	290	221	221	Natural variant	ID=VAR_057002;Note=A->P;Dbxref=dbSNP:rs11541811
TCOF1	Q13428	496	568	516	516	Natural variant	ID=VAR_005631;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs138645438,PMID:9042910
TCOF1	Q13428	496	568	516	516	Natural variant	ID=VAR_005631;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs138645438,PMID:9042910
TCOF1	Q13428	1261	1448	1280	1280	Natural variant	ID=VAR_059730;Note=G->R;Dbxref=dbSNP:rs11541812
TCOF1	Q13428	1260	1447	1280	1280	Natural variant	ID=VAR_059730;Note=G->R;Dbxref=dbSNP:rs11541812
TCOF1	Q13428	1261	1448	1390	1390	Natural variant	ID=VAR_005633;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs15251,PMID:9042910
TCOF1	Q13428	1260	1447	1390	1390	Natural variant	ID=VAR_005633;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs15251,PMID:9042910
TCOF1	Q13428	1261	1448	1431	1431	Natural variant	ID=VAR_061709;Note=G->A;Dbxref=dbSNP:rs45491898
TCOF1	Q13428	1260	1447	1431	1431	Natural variant	ID=VAR_061709;Note=G->A;Dbxref=dbSNP:rs45491898
TCOF1	Q13428	1261	1448	1432	1432	Natural variant	ID=VAR_005634;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs151344580,PMID:9042910
TCOF1	Q13428	1260	1447	1432	1432	Natural variant	ID=VAR_005634;Note=D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9042910;Dbxref=dbSNP:rs151344580,PMID:9042910
TCOF1	Q13428	1261	1448	1271	1271	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCOF1	Q13428	1260	1447	1271	1271	Sequence conflict	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCOF1	Q13428	1261	1448	1389	1389	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
TCOF1	Q13428	1260	1447	1389	1389	Sequence conflict	Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
THBS1	P07996	490	548	19	1170	Chain	ID=PRO_0000035842;Note=Thrombospondin-1
THBS1	P07996	490	548	435	490	Domain	Note=TSP type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THBS1	P07996	490	548	492	547	Domain	Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210
THBS1	P07996	490	548	547	587	Domain	Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
THBS1	P07996	490	548	498	498	Glycosylation	ID=CAR_000210;Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11067851;Dbxref=PMID:11067851
THBS1	P07996	490	548	507	507	Glycosylation	ID=CAR_000211;Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11067851,ECO:0000269|PubMed:12391027;Dbxref=PMID:11067851,PMID:12391027
THBS1	P07996	490	548	504	541	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1LSL,ECO:0000269|PubMed:12391027;Dbxref=PMID:12391027
THBS1	P07996	490	548	508	546	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1LSL,ECO:0000269|PubMed:12391027;Dbxref=PMID:12391027
THBS1	P07996	490	548	519	531	Disulfide bond	Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:1LSL,ECO:0000269|PubMed:12391027;Dbxref=PMID:12391027
THBS1	P07996	490	548	523	523	Natural variant	ID=VAR_028938;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:2918029;Dbxref=dbSNP:rs2292305,PMID:14702039,PMID:2918029
THBS1	P07996	490	548	546	546	Sequence conflict	Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305
THBS1	P07996	490	548	507	509	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LSL
THBS1	P07996	490	548	511	516	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LSL
THBS1	P07996	490	548	535	541	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LSL
TIA1	P31483	92	103	1	386	Chain	ID=PRO_0000031031;Note=Nucleolysin TIA-1 isoform p40
TIA1	P31483	92	103	93	104	Alternative sequence	ID=VSP_005892;Note=In isoform Short. SSTVVSTQRSQD->N;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1934064;Dbxref=PMID:1934064
TMED2	Q15363	124	160	21	201	Chain	ID=PRO_0000010381;Note=Transmembrane emp24 domain-containing protein 2
TMED2	Q15363	124	160	21	168	Topological domain	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255
TMED2	Q15363	124	160	1	181	Region	Note=Interaction with F2RL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17693410;Dbxref=PMID:17693410
TMED2	Q15363	124	160	118	157	Region	Note=Required for TMED10 and TMED2 cis-Golgi network localization
TMED2	Q15363	124	160	117	167	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNRC6B	Q9UPQ9	1309	1368	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	994	1019	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	1170	1202	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	152	935	1	1833	Chain	ID=PRO_0000072605;Note=Trinucleotide repeat-containing gene 6B protein
TNRC6B	Q9UPQ9	994	1019	1	994	Region	Note=Interaction with argonaute proteins
TNRC6B	Q9UPQ9	152	935	1	994	Region	Note=Interaction with argonaute proteins
TNRC6B	Q9UPQ9	1309	1368	1218	1723	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6B	Q9UPQ9	152	935	825	880	Compositional bias	Note=Pro-rich
TNRC6B	Q9UPQ9	1170	1202	1150	1220	Compositional bias	Note=Gln-rich
TNRC6B	Q9UPQ9	152	935	879	879	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:21406692,PMID:23186163,PMID:24275569
TNRC6B	Q9UPQ9	152	935	153	935	Alternative sequence	ID=VSP_037291;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
TNRC6B	Q9UPQ9	1170	1202	1138	1194	Alternative sequence	ID=VSP_037293;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10470851,ECO:0000303|PubMed:15489334;Dbxref=PMID:10470851,PMID:15489334
TNRC6B	Q9UPQ9	152	935	517	517	Natural variant	ID=VAR_051452;Note=S->C;Dbxref=dbSNP:rs17001767
TNRC6B	Q9UPQ9	1309	1368	1321	1321	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TNRC6C	Q9HCJ0	1020	1070	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	926	953	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1070	1119	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1119	1159	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1267	1323	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1435	1500	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1323	1387	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1020	1070	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	926	953	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1070	1119	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1119	1159	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1267	1323	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1435	1500	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	1323	1387	1	1690	Chain	ID=PRO_0000278526;Note=Trinucleotide repeat-containing gene 6C protein
TNRC6C	Q9HCJ0	926	953	933	978	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
TNRC6C	Q9HCJ0	926	953	933	978	Domain	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212
TNRC6C	Q9HCJ0	926	953	1	926	Region	Note=Sufficient for interaction with argonaute family proteins
TNRC6C	Q9HCJ0	926	953	1	926	Region	Note=Sufficient for interaction with argonaute family proteins
TNRC6C	Q9HCJ0	1267	1323	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1435	1500	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1323	1387	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1267	1323	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1435	1500	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1323	1387	1260	1690	Region	Note=Silencing domain%3B interaction with CNOT1 and PAN3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21981923;Dbxref=PMID:21981923
TNRC6C	Q9HCJ0	1435	1500	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1323	1387	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1435	1500	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1323	1387	1371	1690	Region	Note=Sufficient for translational repression when tethered to a target mRNA
TNRC6C	Q9HCJ0	1323	1387	1371	1417	Region	Note=Required for interaction with PABPC1
TNRC6C	Q9HCJ0	1323	1387	1371	1417	Region	Note=Required for interaction with PABPC1
TNRC6C	Q9HCJ0	1323	1387	1381	1399	Region	Note=PABPC1-interacting motif-2 (PAM2)
TNRC6C	Q9HCJ0	1323	1387	1381	1399	Region	Note=PABPC1-interacting motif-2 (PAM2)
TNRC6C	Q9HCJ0	1119	1159	1156	1214	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNRC6C	Q9HCJ0	1119	1159	1156	1214	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TNRC6C	Q9HCJ0	1435	1500	1435	1435	Alternative sequence	ID=VSP_023322;Note=In isoform 2. G->GGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TNRC6C	Q9HCJ0	1435	1500	1435	1435	Alternative sequence	ID=VSP_023322;Note=In isoform 2. G->GGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334
TNRC6C	Q9HCJ0	1267	1323	1294	1300	Mutagenesis	Note=Abolishes association with CCR4-NOT complex. QSRLPQW->AAAAPAA
TNRC6C	Q9HCJ0	1267	1323	1294	1300	Mutagenesis	Note=Abolishes association with CCR4-NOT complex. QSRLPQW->AAAAPAA
TNRC6C	Q9HCJ0	1435	1500	1445	1445	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1487%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1445	1445	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1487%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1487	1487	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1487	1487	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1494%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1494	1494	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1487%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	1435	1500	1494	1494	Mutagenesis	Note=Abolishes translational repression when tethered to a target mRNA%2C abolishes association with the CCR4-NOT complex%3B when associated with A-1445%2C A-1487%2C A-1504%2C A-1515%2C A-1605 and A-1648. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21984184;Dbxref=PMID:21984184
TNRC6C	Q9HCJ0	926	953	936	950	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKL
TNRC6C	Q9HCJ0	926	953	936	950	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DKL
TPR	P12270	1963	2007	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	1868	1896	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	1250	1296	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	2189	2221	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	2313	2345	2	2363	Chain	ID=PRO_0000204920;Note=Nucleoprotein TPR
TPR	P12270	1250	1296	1218	1320	Region	Note=Necessary for interaction with HSF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897941;Dbxref=PMID:17897941
TPR	P12270	1250	1296	1215	1630	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TPR	P12270	1963	2007	1971	1978	Compositional bias	Note=Poly-Asp
TPR	P12270	1868	1896	1893	1893	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569
TPR	P12270	2313	2345	2343	2343	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4
TPR	P12270	2313	2345	2345	2345	Modified residue	Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4
TPR	P12270	1963	2007	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	1868	1896	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	1250	1296	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	2189	2221	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	2313	2345	727	2363	Alternative sequence	ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355
TPR	P12270	1963	2007	1952	1965	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAP1	Q12931	29	82	1	59	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	110	157	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
TRAP1	Q12931	29	82	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
TRAP1	Q12931	157	181	60	704	Chain	ID=PRO_0000013604;Note=Heat shock protein 75 kDa%2C mitochondrial
TRAP1	Q12931	110	157	119	119	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	157	181	158	158	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	157	181	171	171	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRAP1	Q12931	157	181	170	170	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5XHZ0
TRAP1	Q12931	157	181	174	174	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5XHZ0
TRAP1	Q12931	29	82	30	82	Alternative sequence	ID=VSP_055061;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TRAP1	Q12931	29	82	53	53	Sequence conflict	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRAP1	Q12931	110	157	108	110	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	111	134	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	143	148	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	149	152	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	110	157	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	157	181	153	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	157	181	165	176	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRAP1	Q12931	157	181	179	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5F3K
TRIP4	Q15650	276	347	2	581	Chain	ID=PRO_0000065631;Note=Activating signal cointegrator 1
TRIP4	Q15650	135	206	2	581	Chain	ID=PRO_0000065631;Note=Activating signal cointegrator 1
TRIP4	Q15650	135	206	171	187	Zinc finger	Note=C4-type
TRIP4	Q15650	276	347	200	300	Region	Note=Mediates interaction with DDRGK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	135	206	200	300	Region	Note=Mediates interaction with DDRGK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	300	400	Region	Note=Mediates interaction with UFL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	276	276	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRIP4	Q15650	276	347	289	289	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QXN3
TRIP4	Q15650	276	347	341	341	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TRIP4	Q15650	276	347	324	324	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	325	325	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	276	347	334	334	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1);Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25219498;Dbxref=PMID:25219498
TRIP4	Q15650	135	206	157	157	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP4	Q15650	135	206	157	157	Sequence conflict	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRIP4	Q15650	135	206	164	164	Sequence conflict	Note=L->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
TRNAU1AP	Q9NX07	137	176	1	287	Chain	ID=PRO_0000304917;Note=tRNA selenocysteine 1-associated protein 1
TRNAU1AP	Q9NX07	137	176	96	175	Domain	Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176
TRNAU1AP	Q9NX07	137	176	136	145	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TRNAU1AP	Q9NX07	137	176	147	156	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TRNAU1AP	Q9NX07	137	176	157	159	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TRNAU1AP	Q9NX07	137	176	162	166	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DHG
TRUB2	O95900	80	105	11	331	Chain	ID=PRO_0000252090;Note=Mitochondrial mRNA pseudouridine synthase TRUB2
TRUB2	O95900	80	105	98	98	Active site	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250
TRUB2	O95900	80	105	93	93	Natural variant	ID=VAR_027749;Note=V->L;Dbxref=dbSNP:rs2072394
TSC1	Q92574	70	121	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	834	875	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	938	991	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	444	479	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	70	121	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	834	875	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	938	991	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	444	479	1	1164	Chain	ID=PRO_0000065651;Note=Hamartin
TSC1	Q92574	834	875	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	938	991	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	834	875	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	938	991	721	997	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
TSC1	Q92574	70	121	70	120	Alternative sequence	ID=VSP_042890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSC1	Q92574	70	121	70	120	Alternative sequence	ID=VSP_042890;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
TSC1	Q92574	70	121	72	72	Natural variant	ID=VAR_054387;Note=In TSC1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10533069;Dbxref=dbSNP:rs118203354,PMID:10533069
TSC1	Q92574	70	121	72	72	Natural variant	ID=VAR_054387;Note=In TSC1. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10533069;Dbxref=dbSNP:rs118203354,PMID:10533069
TSC1	Q92574	70	121	117	117	Natural variant	ID=VAR_070637;Note=In TSC1%3B reduced expression%3B altered subcellular localization%3B reduced interaction with TSC2%3B reduced inhibition of TORC1 signaling. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18830229,ECO:0000269|PubMed:22161988,ECO:0000269|PubMed:29127155;Dbxref=dbSNP:rs118203368,PMID:18830229,PMID:22161988,PMID:29127155
TSC1	Q92574	70	121	117	117	Natural variant	ID=VAR_070637;Note=In TSC1%3B reduced expression%3B altered subcellular localization%3B reduced interaction with TSC2%3B reduced inhibition of TORC1 signaling. L->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18830229,ECO:0000269|PubMed:22161988,ECO:0000269|PubMed:29127155;Dbxref=dbSNP:rs118203368,PMID:18830229,PMID:22161988,PMID:29127155
TSC1	Q92574	834	875	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	938	991	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	444	479	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	834	875	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	938	991	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	444	479	165	1164	Natural variant	ID=VAR_078845;Note=In TSC1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11829138;Dbxref=PMID:11829138
TSC1	Q92574	444	479	448	448	Natural variant	ID=VAR_070651;Note=Rare polymorphism%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs118203518,PMID:22161988
TSC1	Q92574	444	479	448	448	Natural variant	ID=VAR_070651;Note=Rare polymorphism%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs118203518,PMID:22161988
TSC1	Q92574	938	991	978	978	Natural variant	ID=VAR_070661;Note=In TSC1%3B unknown pathological significance%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs397514859,PMID:22161988
TSC1	Q92574	938	991	978	978	Natural variant	ID=VAR_070661;Note=In TSC1%3B unknown pathological significance%3B no effect on expression%3B no effect on subcellular localization%3B no effect on inhibition of TORC1 signaling. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22161988;Dbxref=dbSNP:rs397514859,PMID:22161988
TSC1	Q92574	938	991	941	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TSC1	Q92574	938	991	941	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TSC1	Q92574	938	991	975	991	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TSC1	Q92574	938	991	975	991	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4Z6Y
TUFM	P49411	272	307	44	452	Chain	ID=PRO_0000007462;Note=Elongation factor Tu%2C mitochondrial
TUFM	P49411	272	307	278	278	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
TUFM	P49411	272	307	286	286	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BFR5
TYMS	P04818	244	268	2	313	Chain	ID=PRO_0000140901;Note=Thymidylate synthase
TYMS	P04818	151	185	2	313	Chain	ID=PRO_0000140901;Note=Thymidylate synthase
TYMS	P04818	151	185	175	176	Nucleotide binding	Note=dUMP%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0A884
TYMS	P04818	244	268	256	258	Nucleotide binding	Note=dUMP;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0A884
TYMS	P04818	151	185	69	151	Alternative sequence	ID=VSP_047745;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12706868;Dbxref=PMID:12706868
TYMS	P04818	151	185	152	185	Alternative sequence	ID=VSP_047746;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12706868;Dbxref=PMID:12706868
TYMS	P04818	151	185	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	151	185	156	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EHI
TYMS	P04818	151	185	160	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	151	185	178	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	151	185	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	244	268	244	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	244	268	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
TYMS	P04818	244	268	262	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ED7
UHMK1	Q8TAS1	187	251	1	419	Chain	ID=PRO_0000086777;Note=Serine/threonine-protein kinase Kist
UHMK1	Q8TAS1	187	251	23	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000305
UHMK1	Q8TAS1	187	251	197	197	Natural variant	ID=VAR_041273;Note=Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56201055,PMID:17344846
UNK	Q9C0B0	435	457	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
UNK	Q9C0B0	549	612	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
UNK	Q9C0B0	35	104	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
UNK	Q9C0B0	35	104	84	113	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00723
UNK	Q9C0B0	35	104	70	73	Compositional bias	Note=Poly-Arg
UPF1	Q92900	619	667	1	1129	Chain	ID=PRO_0000080716;Note=Regulator of nonsense transcripts 1
UPF1	Q92900	619	667	647	648	Mutagenesis	Note=Loss of ATPase activity and helicase activity. DE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10999600,ECO:0000269|PubMed:17159905;Dbxref=PMID:10999600,PMID:17159905
UPF1	Q92900	619	667	647	648	Mutagenesis	Note=Loss of ATPase activity and helicase activity. Inhibits ZC3H12A-mediated IL6 mRNA degradation. DE->AA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10999600,ECO:0000269|PubMed:17159905,ECO:0000269|PubMed:26000482;Dbxref=PMID:10999600,PMID:17159905,PMID:26000482
UPF1	Q92900	619	667	600	620	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	622	627	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	630	632	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	634	636	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	642	646	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	649	651	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	654	661	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	662	664	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF1	Q92900	619	667	665	672	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XZO
UPF3A	Q9H1J1	140	173	1	476	Chain	ID=PRO_0000215296;Note=Regulator of nonsense transcripts 3A
UPF3A	Q9H1J1	140	173	66	140	Region	Note=Required for interaction with UPF2
UPF3A	Q9H1J1	140	173	1	325	Alternative sequence	ID=VSP_012961;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UPF3A	Q9H1J1	140	173	141	173	Alternative sequence	ID=VSP_012962;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
UPF3A	Q9H1J1	140	173	143	150	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2L08
UPF3B	Q9BZI7	123	156	1	483	Chain	ID=PRO_0000215297;Note=Regulator of nonsense transcripts 3B
UPF3B	Q9BZI7	156	193	1	483	Chain	ID=PRO_0000215297;Note=Regulator of nonsense transcripts 3B
UPF3B	Q9BZI7	269	282	1	483	Chain	ID=PRO_0000215297;Note=Regulator of nonsense transcripts 3B
UPF3B	Q9BZI7	123	156	30	255	Region	Note=Necessary for interaction with UPF2
UPF3B	Q9BZI7	156	193	30	255	Region	Note=Necessary for interaction with UPF2
UPF3B	Q9BZI7	123	156	94	483	Region	Note=Sufficient for association with EJC core
UPF3B	Q9BZI7	156	193	94	483	Region	Note=Sufficient for association with EJC core
UPF3B	Q9BZI7	269	282	94	483	Region	Note=Sufficient for association with EJC core
UPF3B	Q9BZI7	156	193	169	169	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163
UPF3B	Q9BZI7	269	282	270	282	Alternative sequence	ID=VSP_012963;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11163187,ECO:0000303|PubMed:15489334;Dbxref=PMID:11163187,PMID:15489334
UPF3B	Q9BZI7	156	193	160	160	Natural variant	ID=VAR_037666;Note=In MRXS14. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17704778;Dbxref=dbSNP:rs122468182,PMID:17704778
UPF3B	Q9BZI7	123	156	126	128	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UW4
UPF3B	Q9BZI7	123	156	130	133	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UW4
UQCC2	Q9BRT2	46	71	14	126	Chain	ID=PRO_0000089526;Note=Ubiquinol-cytochrome-c reductase complex assembly factor 2
WARS2	Q9UGM6	30	116	19	360	Chain	ID=PRO_0000035828;Note=Tryptophan--tRNA ligase%2C mitochondrial
WARS2	Q9UGM6	30	116	48	51	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	42	42	Binding site	Note=ATP;Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	45	45	Natural variant	ID=VAR_079734;Note=In NEMMLAS. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28905505;Dbxref=PMID:28905505
WARS2	Q9UGM6	30	116	50	50	Natural variant	ID=VAR_028848;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11552864,PMID:15489334
WARS2	Q9UGM6	30	116	77	77	Natural variant	ID=VAR_079735;Note=In NEMMLAS%3B unknown pathological significance. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28905505;Dbxref=dbSNP:rs766501807,PMID:28905505
WARS2	Q9UGM6	30	116	100	100	Natural variant	ID=VAR_079736;Note=In NEMMLAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28650581;Dbxref=PMID:28650581
WARS2	Q9UGM6	30	116	37	41	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	43	45	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	49	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	56	65	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	69	73	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	75	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	85	102	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	106	108	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	109	113	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
WARS2	Q9UGM6	30	116	114	116	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5EKD
XRN1	Q8IZH2	1467	1505	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	172	209	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	834	872	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	531	571	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	449	478	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	1068	1087	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	1539	1552	1	1706	Chain	ID=PRO_0000071392;Note=5'-3' exoribonuclease 1
XRN1	Q8IZH2	449	478	449	459	Alternative sequence	ID=VSP_016692;Note=In isoform 3. DDFLADQAACY->EYVFANAFILK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1467	1505	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	834	872	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	531	571	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	449	478	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1068	1087	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1539	1552	460	1706	Alternative sequence	ID=VSP_016693;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
XRN1	Q8IZH2	1539	1552	1540	1552	Alternative sequence	ID=VSP_016695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
XRN1	Q8IZH2	834	872	834	834	Sequence conflict	Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
YARS2	Q9Y2Z4	368	424	17	477	Chain	ID=PRO_0000035830;Note=Tyrosine--tRNA ligase%2C mitochondrial
YARS2	Q9Y2Z4	260	315	17	477	Chain	ID=PRO_0000035830;Note=Tyrosine--tRNA ligase%2C mitochondrial
YARS2	Q9Y2Z4	260	315	281	285	Motif	Note="KMSKS" region;Ontology_term=ECO:0000305;evidence=ECO:0000305
YARS2	Q9Y2Z4	260	315	274	274	Binding site	Note=ATP%3B via amide nitrogen and carbonyl oxygen;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:2PID,ECO:0000244|PDB:3ZXI,ECO:0000269|PubMed:17997975;Dbxref=PMID:17997975
YARS2	Q9Y2Z4	260	315	284	284	Binding site	Note=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
YARS2	Q9Y2Z4	260	315	272	272	Sequence conflict	Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
YARS2	Q9Y2Z4	260	315	311	311	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
YARS2	Q9Y2Z4	260	315	248	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	267	271	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	291	293	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	294	296	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	299	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	260	315	311	321	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YARS2	Q9Y2Z4	368	424	344	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PID
YBX1	P67809	118	219	2	324	Chain	ID=PRO_0000100219;Note=Nuclease-sensitive element-binding protein 1
YBX1	P67809	88	118	2	324	Chain	ID=PRO_0000100219;Note=Nuclease-sensitive element-binding protein 1
YBX1	P67809	118	219	61	125	Domain	Note=CSD
YBX1	P67809	88	118	61	125	Domain	Note=CSD
YBX1	P67809	118	219	219	220	Site	Note=Cleavage%3B by 20S proteasomal protease
YBX1	P67809	88	118	102	102	Modified residue	Note=Phosphoserine%3B by PKB/AKT1;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000269|PubMed:15806160;Dbxref=PMID:19690332,PMID:15806160
YBX1	P67809	118	219	162	162	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:15592455;Dbxref=PMID:15592455
YBX1	P67809	118	219	165	165	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.6;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163
YBX1	P67809	118	219	167	167	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:24275569
YBX1	P67809	118	219	174	174	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
YBX1	P67809	118	219	176	176	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569
YBX1	P67809	118	219	137	137	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18851979;Dbxref=PMID:18851979
YBX1	P67809	88	118	102	102	Mutagenesis	Note=Loss of phosphorylation by PKB/AKT1. Inhibits translocation to the nucleus and tumor cell growth. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15806160;Dbxref=PMID:15806160
YBX1	P67809	118	219	120	120	Sequence conflict	Note=A->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
YBX1	P67809	88	118	88	90	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YBX1	P67809	88	118	108	115	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YBX1	P67809	118	219	117	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YBX1	P67809	88	118	117	125	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1H95
YBX2	Q9Y2T7	123	153	1	364	Chain	ID=PRO_0000100225;Note=Y-box-binding protein 2
YBX2	Q9Y2T7	123	153	93	163	Domain	Note=CSD
YBX2	Q9Y2T7	123	153	87	169	Region	Note=Required for cytoplasmic retention;Ontology_term=ECO:0000250;evidence=ECO:0000250
YBX3	P16989	191	260	2	372	Chain	ID=PRO_0000100214;Note=Y-box-binding protein 3
YBX3	P16989	191	260	201	201	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
YBX3	P16989	191	260	203	203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
YBX3	P16989	191	260	204	204	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231
YBX3	P16989	191	260	251	251	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
YBX3	P16989	191	260	192	260	Alternative sequence	ID=VSP_001135;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
YTHDF1	Q9BYJ9	44	551	2	559	Chain	ID=PRO_0000223073;Note=YTH domain-containing family protein 1
YTHDF1	Q9BYJ9	44	551	389	523	Domain	Note=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
YTHDF1	Q9BYJ9	44	551	395	397	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	411	412	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	241	331	Compositional bias	Note=Gln/Pro-rich
YTHDF1	Q9BYJ9	44	551	401	401	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	441	441	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y5A9
YTHDF1	Q9BYJ9	44	551	465	465	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	470	470	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RCJ,ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	182	182	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YTHDF1	Q9BYJ9	44	551	1	190	Alternative sequence	ID=VSP_006815;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YTHDF1	Q9BYJ9	44	551	191	260	Alternative sequence	ID=VSP_006816;Note=In isoform 2. KIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGL->MLFLGSLGAWGTTSISTGSIFSLKTLRSQHGGQVGLKVSRPRAPRMGAATPTPRAPWVARWLMGSQAFTATPSAR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YTHDF1	Q9BYJ9	44	551	383	559	Alternative sequence	ID=VSP_006817;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
YTHDF1	Q9BYJ9	44	551	397	397	Mutagenesis	Note=Strongly reduced binding to N6-methyladenosine (m6A)-containing RNAs. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	401	401	Mutagenesis	Note=Increased binding to N6-methyladenosine (m6A)-containing RNAs. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	411	411	Mutagenesis	Note=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	465	465	Mutagenesis	Note=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	470	470	Mutagenesis	Note=Abolished binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	506	506	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26318451;Dbxref=PMID:26318451
YTHDF1	Q9BYJ9	44	551	123	124	Sequence conflict	Note=FP->AR;Ontology_term=ECO:0000305;evidence=ECO:0000305
YTHDF1	Q9BYJ9	44	551	283	284	Sequence conflict	Note=AP->PH;Ontology_term=ECO:0000305;evidence=ECO:0000305
YTHDF1	Q9BYJ9	44	551	366	374	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	390	397	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	399	408	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	415	428	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	434	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	443	452	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	457	459	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	465	467	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	473	485	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	486	488	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	489	491	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	495	497	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	502	504	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	513	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	532	535	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF1	Q9BYJ9	44	551	536	550	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RCJ
YTHDF2	Q9Y5A9	44	572	2	579	Chain	ID=PRO_0000223075;Note=YTH domain-containing family protein 2
YTHDF2	Q9Y5A9	44	572	2	579	Chain	ID=PRO_0000223075;Note=YTH domain-containing family protein 2
YTHDF2	Q9Y5A9	44	572	410	544	Domain	Note=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
YTHDF2	Q9Y5A9	44	572	410	544	Domain	Note=YTH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00225
YTHDF2	Q9Y5A9	44	572	2	384	Region	Note=Localization to mRNA processing bodies (P-bodies);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	2	384	Region	Note=Localization to mRNA processing bodies (P-bodies);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	385	579	Region	Note=Interaction with m6A-containing mRNAs;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	385	579	Region	Note=Interaction with m6A-containing mRNAs;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24284625;Dbxref=PMID:24284625
YTHDF2	Q9Y5A9	44	572	416	418	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	416	418	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	432	433	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	432	433	Region	Note=N6-methyladenosine binding;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	422	422	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	422	422	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	462	462	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	462	462	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	486	486	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	486	486	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	491	491	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	491	491	Binding site	Note=N6-methyladenosine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:4RDN,ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YTHDF2	Q9Y5A9	44	572	196	196	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
YTHDF2	Q9Y5A9	44	572	359	359	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
YTHDF2	Q9Y5A9	44	572	359	359	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
YTHDF2	Q9Y5A9	44	572	394	394	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
YTHDF2	Q9Y5A9	44	572	394	394	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
YTHDF2	Q9Y5A9	44	572	1	50	Alternative sequence	ID=VSP_009297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
YTHDF2	Q9Y5A9	44	572	1	50	Alternative sequence	ID=VSP_009297;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.3;Dbxref=PMID:14702039
YTHDF2	Q9Y5A9	44	572	217	217	Natural variant	ID=VAR_053744;Note=T->S;Dbxref=dbSNP:rs16838382
YTHDF2	Q9Y5A9	44	572	217	217	Natural variant	ID=VAR_053744;Note=T->S;Dbxref=dbSNP:rs16838382
YTHDF2	Q9Y5A9	44	572	454	454	Natural variant	ID=VAR_053745;Note=P->S;Dbxref=dbSNP:rs35288745
YTHDF2	Q9Y5A9	44	572	454	454	Natural variant	ID=VAR_053745;Note=P->S;Dbxref=dbSNP:rs35288745
YTHDF2	Q9Y5A9	44	572	411	411	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	411	411	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	416	416	Mutagenesis	Note=Decreased binding to RNAs. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	416	416	Mutagenesis	Note=Decreased binding to RNAs. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	432	432	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	432	432	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	441	441	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	441	441	Mutagenesis	Note=Slightly decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	486	486	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	486	486	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661;Dbxref=PMID:25412658,PMID:25412661
YTHDF2	Q9Y5A9	44	572	491	491	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	491	491	Mutagenesis	Note=Reduced binding to N6-methyladenosine (m6A)-containing RNAs. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412658;Dbxref=PMID:25412658
YTHDF2	Q9Y5A9	44	572	527	527	Mutagenesis	Note=Decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	527	527	Mutagenesis	Note=Decreased binding to RNAs. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25412661;Dbxref=PMID:25412661
YTHDF2	Q9Y5A9	44	572	411	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	411	418	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	420	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	420	429	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	430	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WQN
YTHDF2	Q9Y5A9	44	572	430	432	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WQN
YTHDF2	Q9Y5A9	44	572	436	449	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	436	449	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	455	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	455	461	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	464	473	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	464	473	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDO
YTHDF2	Q9Y5A9	44	572	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDO
YTHDF2	Q9Y5A9	44	572	486	488	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	486	488	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	494	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	494	506	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	507	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	507	509	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	510	512	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	510	512	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	516	520	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	516	520	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	523	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	523	525	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	534	546	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
YTHDF2	Q9Y5A9	44	572	534	546	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4RDN
ZC3H15	Q8WU90	239	288	1	426	Chain	ID=PRO_0000324642;Note=Zinc finger CCCH domain-containing protein 15
ZC3H15	Q8WU90	239	288	236	260	Region	Note=Required for interaction with DRG1;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZC3H15	Q8WU90	239	288	218	285	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
ZNF385A	Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
ZNF385A	Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
ZNF385A	Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
ZNF385A	Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
ZNF385A	Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
ZNF385A	Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
ZNF385A	Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
ZNF385A	Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
ZNF385A	Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZNF385A	Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZNF385A	Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
ZNF385A	Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
ZNF385A	Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
ZNF385A	Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039
ZNF540	Q8NDQ6	45	77	1	660	Chain	ID=PRO_0000047641;Note=Zinc finger protein 540
ZNF540	Q8NDQ6	45	77	1	660	Chain	ID=PRO_0000047641;Note=Zinc finger protein 540
ZNF540	Q8NDQ6	45	77	1	660	Chain	ID=PRO_0000047641;Note=Zinc finger protein 540
ZNF540	Q8NDQ6	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF540	Q8NDQ6	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF540	Q8NDQ6	45	77	6	77	Domain	Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119
ZNF540	Q8NDQ6	45	77	1	77	Alternative sequence	ID=VSP_016036;Note=In isoform 4. MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCP->MLPNFKLYNFIEIFFKPLTPSKNRFHFVSYFENVNFMLCWLQENNFCLLLCFLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF540	Q8NDQ6	45	77	1	77	Alternative sequence	ID=VSP_016036;Note=In isoform 4. MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCP->MLPNFKLYNFIEIFFKPLTPSKNRFHFVSYFENVNFMLCWLQENNFCLLLCFLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF540	Q8NDQ6	45	77	1	77	Alternative sequence	ID=VSP_016036;Note=In isoform 4. MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCP->MLPNFKLYNFIEIFFKPLTPSKNRFHFVSYFENVNFMLCWLQENNFCLLLCFLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
ZNF540	Q8NDQ6	45	77	46	77	Alternative sequence	ID=VSP_016037;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF540	Q8NDQ6	45	77	46	77	Alternative sequence	ID=VSP_016037;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF540	Q8NDQ6	45	77	46	77	Alternative sequence	ID=VSP_016037;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
ZNF540	Q8NDQ6	45	77	53	53	Natural variant	ID=VAR_033575;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1975937,PMID:14702039
ZNF540	Q8NDQ6	45	77	53	53	Natural variant	ID=VAR_033575;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1975937,PMID:14702039
ZNF540	Q8NDQ6	45	77	53	53	Natural variant	ID=VAR_033575;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs1975937,PMID:14702039