UTHEALTH HOUSTON    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY

FGfuncLLM Logo

Home

Download

Statistics

Examples

Help

Contact

Help page

check button 1. Understanding FGfuncLLM's Annotation Categories
 
check button 2. Fusion Gene Search Page
Search page, example: ALK
Input query
 - Official HUGO gene symbol.
 
check button 3. FusionGene Search Result Page
 Select your kinase fusion gene from the fusion gene list.
We provide a classification in the first query search results into two Levels.
 
check button 4. FGfuncLLM's Fusion Gene Annotation Result Page
 These are FGfuncLLM's annotation categories for your query with links to their corresponding annotation parts.
 
check button 1) Fusion Gene Summary.
The 'Fusion Gene Summary' category provides a gene information involved in the fusion gene.
 
check button 2) Most frequent breakpoint information of this fusion gene for domain retention search.
This category provides the most frequent breakpoint information of this fusion gene for the genomic regulation and protein domain retention search.
 
check button 3) Suggested possible scenarios of the mechanisms of action of fusion gene with reasoning.
This category provides all the suggested possible tumorigenic scenarios of the mechanisms of action of the input fusion gene.
 
check button 4) Summary of the suggested possible tumorigenesis scenarios.
This category provides the summary of the suggested scenarios..
 
check button 5. Detailed Information Page for the Chosen Scenario of the Mechanism of Action of Fusion Gene
 These are FGfuncLLM's annotation categories for your query with links to their corresponding annotation parts.
 
check button 1) Senario.
The 'Fusion Gene and Diseases from the Found PubMed Abstracts' category provides the disease information from the MeSH term of our found PubMed Abstracts.
 
check button 2) Prompt part for the gene summary and gene groups.
The 'Fusion Gene and Diseases from the Found PubMed Abstracts' category provides the disease information from the MeSH term of our found PubMed Abstracts.
 
check button 3) Prompt part for the protein domain retention search.
The 'Fusion Gene and Diseases from Manual Curation and Other Resource' category provides the manual curation result of the fusion gene and diseases.
 
check button 4) Prompt part for the gene expression regulation search.
The 'Details of the Found Drugs/Small Molecules' category provides the details of the found drugs/small molecules including general drug information, biochemical properties, and ADME properties.
 
check button 5) Reasoning and Evidence.
The 'Clinical Trials of the Found Drugs/Small Molecules' category provides the previous and current clinical trials information of our found fusion gene and drug/small molecules from clinicaltrials.gov.
 
check button 6) References.
The 'Fusion-Positive Patients' Treatment Records' category provides the treated drugs of the fusion gene-positive patients of TCGA cohorts. It also provides the treatment records of pediatric sarcoma patients from the clinical data warehouse (CDW) of UTHealth.
 
check button 9) Significance.
The 'Generative AI Summary Sentence of the Relationship Between Fusion Gene and Small Molecule that Have at Least Thrree PMIDs from PubMed' category provides one sentence summary of the relationship between fusion gene and each found drug/small molecule from our PubMed search (if they have at least three PMIDs) using the ChatGPT-4.