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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:YIPF1-ZCCHC2 (FusionGDB2 ID:100010)

Fusion Gene Summary for YIPF1-ZCCHC2

Fusion gene summary

Fusion gene information	Fusion gene name: YIPF1-ZCCHC2
	Fusion gene ID: 100010
		Hgene	Tgene
	Gene symbol	YIPF1	ZCCHC2
	Gene ID	54432	54877
	Gene name	Yip1 domain family member 1	zinc finger CCHC-type containing 2
	Synonyms	DJ167A19.1\|FinGER1	C18orf49
	Cytomap	1p32.3	18q21.33
	Type of gene	protein-coding	protein-coding
	Description	protein YIPF1YIP1 family member 1	zinc finger CCHC domain-containing protein 2zinc finger, CCHC domain containing 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000072644, ENST00000539954, ENST00000371399, ENST00000469457,	ENST00000590840, ENST00000269499, ENST00000586834,
Fusion gene scores	* DoF score	5 X 9 X 4=180	7 X 8 X 2=112
	# samples	7	8
	** MAII score	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: YIPF1 [Title/Abstract] AND ZCCHC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	YIPF1(54337044)-ZCCHC2(60223435), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across YIPF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZCCHC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-EQ-A4SO	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+

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Fusion Gene ORF analysis for YIPF1-ZCCHC2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000072644	ENST00000590840	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
5CDS-intron	ENST00000539954	ENST00000590840	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
5UTR-3CDS	ENST00000371399	ENST00000269499	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
5UTR-3CDS	ENST00000371399	ENST00000586834	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
5UTR-3CDS	ENST00000469457	ENST00000269499	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
5UTR-3CDS	ENST00000469457	ENST00000586834	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
5UTR-intron	ENST00000371399	ENST00000590840	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
5UTR-intron	ENST00000469457	ENST00000590840	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
Frame-shift	ENST00000539954	ENST00000269499	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
Frame-shift	ENST00000539954	ENST00000586834	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
In-frame	ENST00000072644	ENST00000269499	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+
In-frame	ENST00000072644	ENST00000586834	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000072644

YIPF1

chr1

54337044

ENST00000269499

ZCCHC2

chr18

60223435

5046

818

930

3041

703

ENST00000072644

YIPF1

chr1

54337044

ENST00000586834

ZCCHC2

chr18

60223435

5042

818

930

3041

703

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000072644	ENST00000269499	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+	0.00020502	0.999795
ENST00000072644	ENST00000586834	YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+	0.000204694	0.9997954

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Fusion Genomic Features for YIPF1-ZCCHC2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+	6.41E-06	0.99999356
YIPF1	chr1	54337044	-	ZCCHC2	chr18	60223435	+	6.41E-06	0.99999356

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for YIPF1-ZCCHC2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:54337044/chr18:60223435)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

141_162

160

422.6666666666667

Topological domain

Lumenal

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

1_119

160

422.6666666666667

Topological domain

Cytoplasmic

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

120_140

160

422.6666666666667

Transmembrane

Helical

Tgene

ZCCHC2

chr1:54337044

chr18:60223435

ENST00000269499

1131_1148

437

1179.0

Zinc finger

CCHC-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

184_200

160

422.6666666666667

Topological domain

Cytoplasmic

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

222_227

160

422.6666666666667

Topological domain

Lumenal

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

249_256

160

422.6666666666667

Topological domain

Cytoplasmic

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

278_306

160

422.6666666666667

Topological domain

Lumenal

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

141_162

259.0

Topological domain

Lumenal

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

184_200

259.0

Topological domain

Cytoplasmic

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

1_119

259.0

Topological domain

Cytoplasmic

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

222_227

259.0

Topological domain

Lumenal

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

249_256

259.0

Topological domain

Cytoplasmic

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

278_306

259.0

Topological domain

Lumenal

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

163_183

160

422.6666666666667

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

201_221

160

422.6666666666667

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

228_248

160

422.6666666666667

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000072644

257_277

160

422.6666666666667

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

120_140

259.0

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

163_183

259.0

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

201_221

259.0

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

228_248

259.0

Transmembrane

Helical

Hgene

YIPF1

chr1:54337044

chr18:60223435

ENST00000371399

257_277

259.0

Transmembrane

Helical

Tgene

ZCCHC2

chr1:54337044

chr18:60223435

ENST00000269499

7_70

437

1179.0

Compositional bias

Note=Pro-rich

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Fusion Gene Sequence for YIPF1-ZCCHC2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>100010_100010_1_YIPF1-ZCCHC2_YIPF1_chr1_54337044_ENST00000072644_ZCCHC2_chr18_60223435_ENST00000269499_length(transcript)=5046nt_BP=818nt
CCGAAACCGGCGCGGAGCAACTGAGGCCCGAGCCTTCTCGGGACCCGGGGGACGCCTAACCCCGCGAGATGAGGAAACTGAGGCCGCGAG
GAGCGCGCATACAGCAGAGAAGCAGCAGAATCGGGAATCAAACCCAGCTCTGTCTGACCCCAGAGCCTGTGCCTTTAACCACTGGCTAGG
CTGAACTGCCTTTGTTCTTCACTGTCCCCATCACCTCTTTCAAACCTCAGCCTCTCCTTCCTCATCGTTACATCTCTAGGCTGCACCTGC
TCTCTAAACATTCACACAAACCCTGCAAATTTTCTTCCTCATAATTGGGAGAAGACTCACTGGCCGAATGGCAGCAGTAGATGACTTGCA
ATTTGAAGAATTTGGCAATGCAGCCACTTCTCTGACAGCAAACCCAGATGCCACCACAGTAAACATTGAGGATCCTGGTGAAACCCCAAA
ACATCAGCCAGGATCCCCAAGAGGCTCAGGAAGAGAAGAAGATGATGAGTTACTGGGAAATGATGACTCTGACAAAACTGAGTTACTTGC
TGGACAGAAGAAAAGCTCCCCCTTCTGGACATTTGAATACTACCAAACATTCTTTGATGTGGACACCTACCAGGTCTTTGACAGAATTAA
AGGATCTCTTTTGCCAATACCCGGGAAAAACTTTGTGAGGTTATATATCCGCAGCAATCCAGATCTCTATGGCCCCTTTTGGATATGTGC
CACGTTGGTCTTTGCCATAGCAATTAGTGGGAATCTTTCCAACTTCTTGATCCATCTGGGAGAGAAGACGTACCATTATGTGCCCGAATT
CCGAAAAGGCAGCTATTTTCAAGTTCATCACAAGCTTTTCTACAAAGTCAGAAAGTACACAGCTTCTTTCAGTCCATATCATCAGACTCC
CTACACAGTATCAATAACTTACAATCCTCTCTGAAGACTTCTAAGATATTAGAACACTTAAAAGAAGACAGCTCTGAAGCTTCAAGTCAA
GAAGAAGATGTGTTGCAGCATGCCATAATCCACAAGAAGCATACTGGGAAAAGTCCCATTGTGAACAATATTGGTACAAGTTGTTCTCCA
TTGGATGGGCTTACCATGCAATATTCTGAACAGAATGGAATTGTGGATTGGAGGAAGCAAAGCTGTACCACCATTCAACACCCAGAGCAC
TGTGTGACCTCGGCTGACCAGCATTCTGCTGAAAAACGGAGTTTATCTTCAATAAATAAGAAGAAAGGAAAGCCACAAACAGAAAAGGAG
AAAATTAAGAAAACTGACAACAGATTGAATAGTAGAATAAATGGTATTAGACTCTCCACTCCTCAGCATGCCCATGGTGGTACTGTGAAA
GATGTGAATTTGGACATTGGCTCTGGACATGACACATGTGGAGAAACATCTTCAGAGAGTTACAGTTCTCCATCTAGTCCCCGACATGAT
GGAAGAGAAAGTTTTGAAAGTGAAGAAGAGAAAGACAGAGACACAGACAGCAATTCTGAGGATTCTGGGAATCCATCAACAACTAGGTTT
ACAGGTTACGGTTCTGTCAACCAGACTGTCACTGTCAAGCCACCTGTTCAAATTGCTTCACTAGGAAATGAGAATGGAAACCTTTTAGAA
GATCCCTTAAACTCACCCAAGTATCAGCATATTTCTTTTATGCCAACGTTACACTGTGTCATGCACAATGGTGCCCAGAAGTCTGAAGTT
GTCGTTCCTGCACCCAAACCCGCTGATGGCAAAACCATAGGGATGCTTGTTCCTAGTCCTGTTGCTATTTCTGCAATAAGGGAGTCTGCA
AATTCAACCCCTGTTGGAATACTAGGGCCAACAGCTTGCACTGGAGAATCGGAAAAGCACCTTGAGTTACTGGCTTCCCCTTTACCTATT
CCATCAACCTTCCTTCCACACAGTAGTACTCCCGCTTTGCATCTTACAGTTCAGAGGCTAAAGTTGCCACCACCACAGGGATCTTCTGAG
AGCTGCACAGTTAACATCCCACAACAACCACCCGGAAGCCTGAGCATCGCATCACCAAACACTGCCTTTATTCCTATCCATAACCCAGGT
AGTTTCCCAGGCTCTCCTGTTGCTACCACGGACCCCATCACAAAATCTGCATCCCAAGTGGTAGGACTCAATCAAATGGTGCCTCAAATT
GAGGGAAACACAGGGACAGTCCCTCAGCCTACCAATGTGAAGGTAGTTCTTCCAGCAGCTGGCCTCTCAGCTGCTCAGCCACCAGCTTCC
TACCCCTTACCAGGCTCTCCCCTTGCTGCCGGCGTGTTACCCAGCCAGAACTCCAGTGTGCTCAGCACAGCAGCAACTTCTCCCCAGCCA
GCGAGCGCAGGTATCAGCCAGGCCCAGGCAACTGTTCCTCCTGCAGTTCCTACCCACACCCCAGGCCCTGCCCCGAGCCCAAGCCCTGCC
TTGACACACAGTACCGCGCAGAGTGACAGCACCTCTTACATCAGTGCTGTGGGGAACACGAACGCTAATGGGACAGTAGTGCCACCGCAG
CAGATGGGCTCAGGTCCTTGTGGTTCTTGTGGGCGAAGGTGCAGCTGTGGGACCAATGGAAACCTTCAGCTAAATAGTTACTATTATCCT
AATCCAATGCCTGGACCAATGTACCGAGTCCCTTCATTCTTTACTCTGCCATCCATTTGCAATGGCAGCTACCTCAACCAAGCACATCAG
AGCAATGGAAACCAACTTCCTTTTTTTCTGCCTCAGACTCCATATGCAAATGGACTGGTACATGACCCAGTCATGGGGAGCCAAGCCAAC
TATGGCATGCAGCAGATGGCAGGATTTGGGAGATTCTATCCTGTATATCCAGCACCTAACGTAGTTGCCAACACCAGTGGTTCGGGGCCC
AAGAAGAATGGGAATGTCTCATGTTACAATTGTGGTGTAAGCGGACACTATGCACAGGACTGTAAGCAGTCGTCCATGGAGGCCAATCAA
CAAGGCACTTACAGACTGAGATACGCACCTCCCCTCCCCCCTTCTAATGATACGTTGGATTCTGCAGACTGAAACGAGTAAAGCTTGCCT
ACTTAATACACTCAAGTGTGGGGAGTCATGGGGTGTGGAGGGGAGGAAAGGAAAGGTATTTTGTTTCTTTGTCTATACATTTCCTAGATT
TCTATGCAGTTGGGATTTTTCATTTCTCTTGTACCAATGTCCAAAACAAGAAAGAATGCAATGCTTTTGAGCCTCTGGTCTCCTGGTTCA
ACAACAGGCTTATATGTATGATACATGTAATTTAAACCTTCAGACAAACTTAAATGTTGGTGCGTGCTTTTTTTTTTTTTTTTACACTGA
ATACTTGCTGTGTGCAATGTTTACTGAATCTTTAAAACTGTGTATTTGACCTTTTTTTTACAACACTGGTGACAGTCATATGGTTTTGAA
AAAAAAAAGAAATTTTGCTTCTTCCCAGCTTTTCTCACTTTCACCCTAAACGACACTTCCTCCCCAGCCAGCCTCACTCTGTCTCCGGCC
CGCAGCAGGAGCAGCCAGCAGTGCATTCACCCCACTTTTGTAAACTGCTCTGCATATAAACCAAGGGCAGAATGTTTCACCCTGATCTTA
TGGGAGGAATCAAACTCCCAAAATAGTGTGTATATATGTAATAAACAGCGTCACGTAAATACATATATGCAGTGCTTGTTGTCCAAATAG
AAATGAAAATAAGTGGAAGAGAGAGGAAGAAGTCAAACCATATGAAACTGAAAAAATATGACGTACGAAATGGACAAAAAGCTTTTTCTG
AAACCAACTTTTTACTTCCATCATCCTTTTTTAGCCTGTTGCTTCAGAGAGACACAAAGTGAACACACTGGTGTGAATGTCGCTCTCTGT
GTGCTTGTGTTTGTAATGAAAGTCTACAGCCAATTTTACTTGTCTACCACCGTGTTGTGCTCAAAGAGACACTACTTGAGTGAAGATTTC
TTCTTTCCCTGTACCAGCTGTTACAGTGTTACGTTGTGTTTAAAATGTGTATGGTTTATTGCAATCTGAACAGAGCTATGGGTTTCTACC
ATAAGTCAGGTTGTTTGTTCCCTAACCTGTCTCTCATAGCAAAGTCACTTTTATAACAGTTTACCACTATGCTTGATTATAATGTGAAAG
GCGGAATTCTGAGTGTGTTAAGATGGTATTAATCATGTCGGTGTCATGTCACTAAGTTTAATGCTGCTGTTTTTAAAAAAAAAAAAAAGT
TTTTTTAAAAAGCCAATCTATGTACTAAATTGCTTCCAGGTAATTTTTGATTTCCTAAAGTGCACTGAGGTTATCTGGAAGATTGGGTGT
ATTTTTTGGTGACTGCTGCATTCATCAGCAATGAACAGTTTCCACTGTATAGTCCTAGGGGTCAGGGGGTGGGGGTTTCATTTTCCATTC
CTCAGCACAGAGCAGAAATGATAGATTTTTATTGTTTGGAGTAACGTTGGTATGCAGCAGAGGAACGTAAACATTTGGTCTTGGTTCAGA
AGCCTAACAGATTGCTAGACAAGAGAAAAAACTTGAAGAAAAAAGAAGCTTAATTTCATGCTTCATAAGTAGCATTTATATTTATAGCAC
CAATGTACATTTTGAAACTTTCTTTCAGGGGTGGGAGTTATGGGGAAGGGGTGGGTGTGAAGGGGTAGATGAAAGCTTTAATTTAGAAAG
AAAGTTCAAGTAAAGGAAATTATTTTGATTAAATATATTTTATTTGATCTGGGTATTTTTGGACCACATTATTAAATTAATTGTTAAGCT
GCAGTTGAGTTGTTCAAGTGAGAGTTTTGATAAGCCACTTATGGGCCGCGTTGTGAATCACTTGCCAGTTGTACTTTATGGAGCTTATTT
TATGATTTAAAATACTGTACTGTACATAGGAGGTATGTTACCTTCTCCTTATTTGTATGTTTACCATATACTTTGATATTTGAAATGTTA
TGTACTGGAAAGGCCACTTATATTTCTAGAACAGATTGGATTTTATGCAACCTTTTTTCCTTGAATTAACAGCAATAAAAAAATGAAAAA

>100010_100010_1_YIPF1-ZCCHC2_YIPF1_chr1_54337044_ENST00000072644_ZCCHC2_chr18_60223435_ENST00000269499_length(amino acids)=703AA_BP=
MKTSKILEHLKEDSSEASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIVDWRKQSCTTIQHPEHCVTSADQHSA
EKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHAHGGTVKDVNLDIGSGHDTCGETSSESYSSPSSPRHDGRESFESEEE
KDRDTDSNSEDSGNPSTTRFTGYGSVNQTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMPTLHCVMHNGAQKSEVVVPAPKPADG
KTIGMLVPSPVAISAIRESANSTPVGILGPTACTGESEKHLELLASPLPIPSTFLPHSSTPALHLTVQRLKLPPPQGSSESCTVNIPQQP
PGSLSIASPNTAFIPIHNPGSFPGSPVATTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVKVVLPAAGLSAAQPPASYPLPGSPLAA
GVLPSQNSSVLSTAATSPQPASAGISQAQATVPPAVPTHTPGPAPSPSPALTHSTAQSDSTSYISAVGNTNANGTVVPPQQMGSGPCGSC
GRRCSCGTNGNLQLNSYYYPNPMPGPMYRVPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPYANGLVHDPVMGSQANYGMQQMAGFG

--------------------------------------------------------------
>100010_100010_2_YIPF1-ZCCHC2_YIPF1_chr1_54337044_ENST00000072644_ZCCHC2_chr18_60223435_ENST00000586834_length(transcript)=5042nt_BP=818nt
CCGAAACCGGCGCGGAGCAACTGAGGCCCGAGCCTTCTCGGGACCCGGGGGACGCCTAACCCCGCGAGATGAGGAAACTGAGGCCGCGAG
GAGCGCGCATACAGCAGAGAAGCAGCAGAATCGGGAATCAAACCCAGCTCTGTCTGACCCCAGAGCCTGTGCCTTTAACCACTGGCTAGG
CTGAACTGCCTTTGTTCTTCACTGTCCCCATCACCTCTTTCAAACCTCAGCCTCTCCTTCCTCATCGTTACATCTCTAGGCTGCACCTGC
TCTCTAAACATTCACACAAACCCTGCAAATTTTCTTCCTCATAATTGGGAGAAGACTCACTGGCCGAATGGCAGCAGTAGATGACTTGCA
ATTTGAAGAATTTGGCAATGCAGCCACTTCTCTGACAGCAAACCCAGATGCCACCACAGTAAACATTGAGGATCCTGGTGAAACCCCAAA
ACATCAGCCAGGATCCCCAAGAGGCTCAGGAAGAGAAGAAGATGATGAGTTACTGGGAAATGATGACTCTGACAAAACTGAGTTACTTGC
TGGACAGAAGAAAAGCTCCCCCTTCTGGACATTTGAATACTACCAAACATTCTTTGATGTGGACACCTACCAGGTCTTTGACAGAATTAA
AGGATCTCTTTTGCCAATACCCGGGAAAAACTTTGTGAGGTTATATATCCGCAGCAATCCAGATCTCTATGGCCCCTTTTGGATATGTGC
CACGTTGGTCTTTGCCATAGCAATTAGTGGGAATCTTTCCAACTTCTTGATCCATCTGGGAGAGAAGACGTACCATTATGTGCCCGAATT
CCGAAAAGGCAGCTATTTTCAAGTTCATCACAAGCTTTTCTACAAAGTCAGAAAGTACACAGCTTCTTTCAGTCCATATCATCAGACTCC
CTACACAGTATCAATAACTTACAATCCTCTCTGAAGACTTCTAAGATATTAGAACACTTAAAAGAAGACAGCTCTGAAGCTTCAAGTCAA
GAAGAAGATGTGTTGCAGCATGCCATAATCCACAAGAAGCATACTGGGAAAAGTCCCATTGTGAACAATATTGGTACAAGTTGTTCTCCA
TTGGATGGGCTTACCATGCAATATTCTGAACAGAATGGAATTGTGGATTGGAGGAAGCAAAGCTGTACCACCATTCAACACCCAGAGCAC
TGTGTGACCTCGGCTGACCAGCATTCTGCTGAAAAACGGAGTTTATCTTCAATAAATAAGAAGAAAGGAAAGCCACAAACAGAAAAGGAG
AAAATTAAGAAAACTGACAACAGATTGAATAGTAGAATAAATGGTATTAGACTCTCCACTCCTCAGCATGCCCATGGTGGTACTGTGAAA
GATGTGAATTTGGACATTGGCTCTGGACATGACACATGTGGAGAAACATCTTCAGAGAGTTACAGTTCTCCATCTAGTCCCCGACATGAT
GGAAGAGAAAGTTTTGAAAGTGAAGAAGAGAAAGACAGAGACACAGACAGCAATTCTGAGGATTCTGGGAATCCATCAACAACTAGGTTT
ACAGGTTACGGTTCTGTCAACCAGACTGTCACTGTCAAGCCACCTGTTCAAATTGCTTCACTAGGAAATGAGAATGGAAACCTTTTAGAA
GATCCCTTAAACTCACCCAAGTATCAGCATATTTCTTTTATGCCAACGTTACACTGTGTCATGCACAATGGTGCCCAGAAGTCTGAAGTT
GTCGTTCCTGCACCCAAACCCGCTGATGGCAAAACCATAGGGATGCTTGTTCCTAGTCCTGTTGCTATTTCTGCAATAAGGGAGTCTGCA
AATTCAACCCCTGTTGGAATACTAGGGCCAACAGCTTGCACTGGAGAATCGGAAAAGCACCTTGAGTTACTGGCTTCCCCTTTACCTATT
CCATCAACCTTCCTTCCACACAGTAGTACTCCCGCTTTGCATCTTACAGTTCAGAGGCTAAAGTTGCCACCACCACAGGGATCTTCTGAG
AGCTGCACAGTTAACATCCCACAACAACCACCCGGAAGCCTGAGCATCGCATCACCAAACACTGCCTTTATTCCTATCCATAACCCAGGT
AGTTTCCCAGGCTCTCCTGTTGCTACCACGGACCCCATCACAAAATCTGCATCCCAAGTGGTAGGACTCAATCAAATGGTGCCTCAAATT
GAGGGAAACACAGGGACAGTCCCTCAGCCTACCAATGTGAAGGTAGTTCTTCCAGCAGCTGGCCTCTCAGCTGCTCAGCCACCAGCTTCC
TACCCCTTACCAGGCTCTCCCCTTGCTGCCGGCGTGTTACCCAGCCAGAACTCCAGTGTGCTCAGCACAGCAGCAACTTCTCCCCAGCCA
GCGAGCGCAGGTATCAGCCAGGCCCAGGCAACTGTTCCTCCTGCAGTTCCTACCCACACCCCAGGCCCTGCCCCGAGCCCAAGCCCTGCC
TTGACACACAGTACCGCGCAGAGTGACAGCACCTCTTACATCAGTGCTGTGGGGAACACGAACGCTAATGGGACAGTAGTGCCACCGCAG
CAGATGGGCTCAGGTCCTTGTGGTTCTTGTGGGCGAAGGTGCAGCTGTGGGACCAATGGAAACCTTCAGCTAAATAGTTACTATTATCCT
AATCCAATGCCTGGACCAATGTACCGAGTCCCTTCATTCTTTACTCTGCCATCCATTTGCAATGGCAGCTACCTCAACCAAGCACATCAG
AGCAATGGAAACCAACTTCCTTTTTTTCTGCCTCAGACTCCATATGCAAATGGACTGGTACATGACCCAGTCATGGGGAGCCAAGCCAAC
TATGGCATGCAGCAGATGGCAGGATTTGGGAGATTCTATCCTGTATATCCAGCACCTAACGTAGTTGCCAACACCAGTGGTTCGGGGCCC
AAGAAGAATGGGAATGTCTCATGTTACAATTGTGGTGTAAGCGGACACTATGCACAGGACTGTAAGCAGTCGTCCATGGAGGCCAATCAA
CAAGGCACTTACAGACTGAGATACGCACCTCCCCTCCCCCCTTCTAATGATACGTTGGATTCTGCAGACTGAAACGAGTAAAGCTTGCCT
ACTTAATACACTCAAGTGTGGGGAGTCATGGGGTGTGGAGGGGAGGAAAGGAAAGGTATTTTGTTTCTTTGTCTATACATTTCCTAGATT
TCTATGCAGTTGGGATTTTTCATTTCTCTTGTACCAATGTCCAAAACAAGAAAGAATGCAATGCTTTTGAGCCTCTGGTCTCCTGGTTCA
ACAACAGGCTTATATGTATGATACATGTAATTTAAACCTTCAGACAAACTTAAATGTTGGTGCGTGCTTTTTTTTTTTTTTTTACACTGA
ATACTTGCTGTGTGCAATGTTTACTGAATCTTTAAAACTGTGTATTTGACCTTTTTTTTACAACACTGGTGACAGTCATATGGTTTTGAA
AAAAAAAAGAAATTTTGCTTCTTCCCAGCTTTTCTCACTTTCACCCTAAACGACACTTCCTCCCCAGCCAGCCTCACTCTGTCTCCGGCC
CGCAGCAGGAGCAGCCAGCAGTGCATTCACCCCACTTTTGTAAACTGCTCTGCATATAAACCAAGGGCAGAATGTTTCACCCTGATCTTA
TGGGAGGAATCAAACTCCCAAAATAGTGTGTATATATGTAATAAACAGCGTCACGTAAATACATATATGCAGTGCTTGTTGTCCAAATAG
AAATGAAAATAAGTGGAAGAGAGAGGAAGAAGTCAAACCATATGAAACTGAAAAAATATGACGTACGAAATGGACAAAAAGCTTTTTCTG
AAACCAACTTTTTACTTCCATCATCCTTTTTTAGCCTGTTGCTTCAGAGAGACACAAAGTGAACACACTGGTGTGAATGTCGCTCTCTGT
GTGCTTGTGTTTGTAATGAAAGTCTACAGCCAATTTTACTTGTCTACCACCGTGTTGTGCTCAAAGAGACACTACTTGAGTGAAGATTTC
TTCTTTCCCTGTACCAGCTGTTACAGTGTTACGTTGTGTTTAAAATGTGTATGGTTTATTGCAATCTGAACAGAGCTATGGGTTTCTACC
ATAAGTCAGGTTGTTTGTTCCCTAACCTGTCTCTCATAGCAAAGTCACTTTTATAACAGTTTACCACTATGCTTGATTATAATGTGAAAG
GCGGAATTCTGAGTGTGTTAAGATGGTATTAATCATGTCGGTGTCATGTCACTAAGTTTAATGCTGCTGTTTTTAAAAAAAAAAAAAAGT
TTTTTTAAAAAGCCAATCTATGTACTAAATTGCTTCCAGGTAATTTTTGATTTCCTAAAGTGCACTGAGGTTATCTGGAAGATTGGGTGT
ATTTTTTGGTGACTGCTGCATTCATCAGCAATGAACAGTTTCCACTGTATAGTCCTAGGGGTCAGGGGGTGGGGGTTTCATTTTCCATTC
CTCAGCACAGAGCAGAAATGATAGATTTTTATTGTTTGGAGTAACGTTGGTATGCAGCAGAGGAACGTAAACATTTGGTCTTGGTTCAGA
AGCCTAACAGATTGCTAGACAAGAGAAAAAACTTGAAGAAAAAAGAAGCTTAATTTCATGCTTCATAAGTAGCATTTATATTTATAGCAC
CAATGTACATTTTGAAACTTTCTTTCAGGGGTGGGAGTTATGGGGAAGGGGTGGGTGTGAAGGGGTAGATGAAAGCTTTAATTTAGAAAG
AAAGTTCAAGTAAAGGAAATTATTTTGATTAAATATATTTTATTTGATCTGGGTATTTTTGGACCACATTATTAAATTAATTGTTAAGCT
GCAGTTGAGTTGTTCAAGTGAGAGTTTTGATAAGCCACTTATGGGCCGCGTTGTGAATCACTTGCCAGTTGTACTTTATGGAGCTTATTT
TATGATTTAAAATACTGTACTGTACATAGGAGGTATGTTACCTTCTCCTTATTTGTATGTTTACCATATACTTTGATATTTGAAATGTTA
TGTACTGGAAAGGCCACTTATATTTCTAGAACAGATTGGATTTTATGCAACCTTTTTTCCTTGAATTAACAGCAATAAAAAAATGAAAAA

>100010_100010_2_YIPF1-ZCCHC2_YIPF1_chr1_54337044_ENST00000072644_ZCCHC2_chr18_60223435_ENST00000586834_length(amino acids)=703AA_BP=
MKTSKILEHLKEDSSEASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIVDWRKQSCTTIQHPEHCVTSADQHSA
EKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHAHGGTVKDVNLDIGSGHDTCGETSSESYSSPSSPRHDGRESFESEEE
KDRDTDSNSEDSGNPSTTRFTGYGSVNQTVTVKPPVQIASLGNENGNLLEDPLNSPKYQHISFMPTLHCVMHNGAQKSEVVVPAPKPADG
KTIGMLVPSPVAISAIRESANSTPVGILGPTACTGESEKHLELLASPLPIPSTFLPHSSTPALHLTVQRLKLPPPQGSSESCTVNIPQQP
PGSLSIASPNTAFIPIHNPGSFPGSPVATTDPITKSASQVVGLNQMVPQIEGNTGTVPQPTNVKVVLPAAGLSAAQPPASYPLPGSPLAA
GVLPSQNSSVLSTAATSPQPASAGISQAQATVPPAVPTHTPGPAPSPSPALTHSTAQSDSTSYISAVGNTNANGTVVPPQQMGSGPCGSC
GRRCSCGTNGNLQLNSYYYPNPMPGPMYRVPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPYANGLVHDPVMGSQANYGMQQMAGFG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for YIPF1-ZCCHC2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for YIPF1-ZCCHC2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for YIPF1-ZCCHC2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source