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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:YIPF6-NUGGC (FusionGDB2 ID:100027)

Fusion Gene Summary for YIPF6-NUGGC

Fusion gene summary

Fusion gene information	Fusion gene name: YIPF6-NUGGC
	Fusion gene ID: 100027
		Hgene	Tgene
	Gene symbol	YIPF6	NUGGC
	Gene ID	286451	389643
	Gene name	Yip1 domain family member 6	nuclear GTPase, germinal center associated
	Synonyms	FinGER6	C8orf80\|HMFN0672\|SLIP-GC
	Cytomap	Xq12-q13.1	8p21.1
	Type of gene	protein-coding	protein-coding
	Description	protein YIPF6YIP1 family member 6	nuclear GTPase SLIP-GCGTPase SLIP-GCspeckled-like pattern in the germinal center
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000470730, ENST00000374622, ENST00000462683,	ENST00000341513, ENST00000413272,
Fusion gene scores	* DoF score	2 X 2 X 2=8	3 X 4 X 3=36
	# samples	2	4
	** MAII score	log2(2/8*10)=1.32192809488736	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: YIPF6 [Title/Abstract] AND NUGGC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	YIPF6(67718965)-NUGGC(27905129), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NUGGC	GO:0071222	cellular response to lipopolysaccharide	19734146

Fusion gene breakpoints across YIPF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUGGC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GU-A767-01A	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-

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Fusion Gene ORF analysis for YIPF6-NUGGC

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000470730	ENST00000341513	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-
3UTR-3CDS	ENST00000470730	ENST00000413272	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-
In-frame	ENST00000374622	ENST00000341513	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-
In-frame	ENST00000374622	ENST00000413272	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-
In-frame	ENST00000462683	ENST00000341513	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-
In-frame	ENST00000462683	ENST00000413272	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000462683	YIPF6	chrX	67718965	+	ENST00000413272	NUGGC	chr8	27905129	-	3339	801	711	1985	424
ENST00000462683	YIPF6	chrX	67718965	+	ENST00000341513	NUGGC	chr8	27905129	-	3337	801	711	1985	424
ENST00000374622	YIPF6	chrX	67718965	+	ENST00000413272	NUGGC	chr8	27905129	-	2610	72	15	1256	413
ENST00000374622	YIPF6	chrX	67718965	+	ENST00000341513	NUGGC	chr8	27905129	-	2608	72	15	1256	413

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000462683	ENST00000413272	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-	0.00664929	0.9933507
ENST00000462683	ENST00000341513	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-	0.006705009	0.993295
ENST00000374622	ENST00000413272	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-	0.00758147	0.9924185
ENST00000374622	ENST00000341513	YIPF6	chrX	67718965	+	NUGGC	chr8	27905129	-	0.007534358	0.9924656

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Fusion Genomic Features for YIPF6-NUGGC

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for YIPF6-NUGGC

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:67718965/chr8:27905129)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUGGC

chrX:67718965

chr8:27905129

ENST00000413272

745_775

402

797.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

106_115

194.0

Topological domain

Lumenal

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

137_146

194.0

Topological domain

Cytoplasmic

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

168_184

194.0

Topological domain

Lumenal

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

206_212

194.0

Topological domain

Cytoplasmic

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

234_236

194.0

Topological domain

Lumenal

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

2_84

194.0

Topological domain

Cytoplasmic

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

106_115

237.0

Topological domain

Lumenal

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

137_146

237.0

Topological domain

Cytoplasmic

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

168_184

237.0

Topological domain

Lumenal

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

206_212

237.0

Topological domain

Cytoplasmic

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

234_236

237.0

Topological domain

Lumenal

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

2_84

237.0

Topological domain

Cytoplasmic

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

116_136

194.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

147_167

194.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

185_205

194.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

213_233

194.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000374622

85_105

194.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

116_136

237.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

147_167

237.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

185_205

237.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

213_233

237.0

Transmembrane

Helical

Hgene

YIPF6

chrX:67718965

chr8:27905129

ENST00000462683

85_105

237.0

Transmembrane

Helical

Tgene

NUGGC

chrX:67718965

chr8:27905129

ENST00000413272

158_185

402

797.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NUGGC

chrX:67718965

chr8:27905129

ENST00000413272

107_114

402

797.0

Nucleotide binding

GTP

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Fusion Gene Sequence for YIPF6-NUGGC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>100027_100027_1_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000374622_NUGGC_chr8_27905129_ENST00000341513_length(transcript)=2608nt_BP=72nt
AGAAGGAGGGCCAAGATGGCGGAAGCGGAGGAGTCTCCAGGAGACCCGGGGACAGCATCGCCCAGGCCCCTGAGAAAACTGCCAGCTGAC
TTCAAGGTTCTGGAAGCCTCAGATCTGGTGTATACAGTCAGCGCCCAGGAGTACTGGCAGCAGGCTCTCCTCACCGAGGAGGAAACGGAA
ATCCCTAAGTTAAGAGAATACATCAGGAAGAGCCTCTTGGACAAGAAGAAGAGGACAGTGACCAAGTATGTGACTGAAGCCTTTGGCCTG
TTGCTCCTCACAGATAGTTTCAACTCCACGCAAAACCTGCCGAATGAACACTTGCACATGAGTGTCCTGCGGAGATTTGCGGAAGAGAAG
GTTGAGCTGCTGGAGAAGGCCATCGCACAGTGCTTCGCCTGCATGGAGCAGCCTCTGCAAGAAGGGGTCAGGACCGCCAGGACTTCTTAC
CGCTGCATCCTCAGAGCATGCTTGGTGAGGAGTAAAGGAAACCAAGGTTTTCATCAGACCCTGAAAGCTGTTTGCCTGAAAAATGGCATC
TATGCCTCCAGGACTCTGGCGAGAATTGATCTAAATGAAGCCCTCACTCAGCCCGTCTATGACCAGATCGACCCTGTTTTTGGAAGCATT
TTTAGGACGGGGAAGCCCACTGGTTCAGCTCTGATGCCTCACATAGATGCTTTTAAGCAGTCCCTGCAGGAGAAAATGACAGAAATTGGG
ATAAGAAGTGGCTGGAAATATGATAGCTGCAAAAAAAATTTCCTGATCCAGGAGATAAGTGCCATCCTCGGGGGCCTGGAGGACCACATC
CTCAGAAGGAAGAGGAGGATCTACGAGTCCCTCACTGCCTCTGTCCAGAGTGACCTGAAGCTCTGTTACGAAGAGGCAGCTCAGATCACG
GGCAAAAAAGCGTGTGAGCGGATGAAAGATGCCATCAGAAGAGGAGTGGACCGGCAGGTGGCTGAGGGCATGTTTGAAAGGGCCCAGGAA
AGGATGCAGCACCAGTTTCAGCAGCTGAAGACTGGAATCGTGGAGAAGGTGAAGGGCAGCATCACCACTATGCTGGCCCTTGCTTCGTCC
CAGGGGGATGGCCTCTACAAGGAGCTTGCAGATGTCGGGAGTGAATACAAGGAGATGGAGAAGCTGCACAGAAGCCTGAGGGAGGTCGCG
GAGAATGCACGGCTGAGGAAGGGCATGCAAGAATTCCTCCTAAGGGCATCCCCCAGCAAGGCTGGCCCCCCCGGGACATCACTGTAACTC
CTGGGGCTTAGTCCCAATGGATGAAAAATCAGCCCAGAGCCAGAGAATTAGAATTACTTTTTTTGTTCTTAAGAGACAAGATCTATCTAC
CTCTGTTGCCCAGGCTGGAGTGCAGTGGCACCATCACAGCTCACTGCAGCCTCGAACTCCTAGGCTCAAGCGATCCTCCAGCCTCAGCCT
CCAGAGCAGCTGGGGCTACAGGTACAGGCCACCACACCTGGGTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTGTGTCACCCA
GGCTGGAATGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGAAATTCTCTGCCTCAGCCTCCCAAGTAGCTGG
GATTATAGGCGACTGCCACCACACCCGGTTAATTTTTATATTTTTAGTAGAGACGGGGTTTCATCATCTTGGCCAGGCTGGTCCTGAACT
CCTGACCTCGTGATCCACCCATCTCTGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCGTGCCCGGCCCATACCTGGGTAATTTT
TTAATTTTTTGTGGAGATGGCATCTTGCTCTGTTGCCCAGGGTGGTCTCAAACTCCTGGCCTCAAGTGATTCTCTCCCACCTCAGTCTCT
TGTGCTAGGATTGCAGGCATGAGCCATTGTGCCTGGCTCAGAATTCTTTCTGTTTTGTGAAATCTAATAGAGGACATTTCTCAACTATTT
GGACTTTGCATGCAATATAAAACTAGTATGTTTACTGCATTTTATTTTATAGCCCCAAAGAGTCATCTTCAATACCTAATGGAGTTCTAA
AGCTTTAGGGCAAGAAACTTTTGCTTCCGCAAAAACATCTAAACATCGCTGGGCATGGTGGCTCACTCCCGTAATCCCAGCACTTTGGGA
GGCTGAGGCGGGCGGATCATGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAATACAAAAAATT
AGCCAGGCGTGGTAGCATGTGCCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCATAGGTTGCAG
TGAGCCAAGGTCGCGCCACTGCACTCCAGCCTGGACGACGGAGTGAGACTATGTCTCAAAAAAAAAAAAAAAAAAAGAAAAAGAAAAAAA
TATATATATATACACACACACACCCATACATAAAAAAACTTAAACATTATAGAAAAAACATTGCACGATATAAAACAAGCCATAAAAAGA

>100027_100027_1_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000374622_NUGGC_chr8_27905129_ENST00000341513_length(amino acids)=413AA_BP=19
MAEAEESPGDPGTASPRPLRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYVTEAFGLLLLTD
SFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSKGNQGFHQTLKAVCLKNGIYASRT
LARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALMPHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKR
RIYESLTASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTMLALASSQGDGL

--------------------------------------------------------------
>100027_100027_2_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000374622_NUGGC_chr8_27905129_ENST00000413272_length(transcript)=2610nt_BP=72nt
AGAAGGAGGGCCAAGATGGCGGAAGCGGAGGAGTCTCCAGGAGACCCGGGGACAGCATCGCCCAGGCCCCTGAGAAAACTGCCAGCTGAC
TTCAAGGTTCTGGAAGCCTCAGATCTGGTGTATACAGTCAGCGCCCAGGAGTACTGGCAGCAGGCTCTCCTCACCGAGGAGGAAACGGAA
ATCCCTAAGTTAAGAGAATACATCAGGAAGAGCCTCTTGGACAAGAAGAAGAGGACAGTGACCAAGTATGTGACTGAAGCCTTTGGCCTG
TTGCTCCTCACAGATAGTTTCAACTCCACGCAAAACCTGCCGAATGAACACTTGCACATGAGTGTCCTGCGGAGATTTGCGGAAGAGAAG
GTTGAGCTGCTGGAGAAGGCCATCGCACAGTGCTTCGCCTGCATGGAGCAGCCTCTGCAAGAAGGGGTCAGGACCGCCAGGACTTCTTAC
CGCTGCATCCTCAGAGCATGCTTGGTGAGGAGTAAAGGAAACCAAGGTTTTCATCAGACCCTGAAAGCTGTTTGCCTGAAAAATGGCATC
TATGCCTCCAGGACTCTGGCGAGAATTGATCTAAATGAAGCCCTCACTCAGCCCGTCTATGACCAGATCGACCCTGTTTTTGGAAGCATT
TTTAGGACGGGGAAGCCCACTGGTTCAGCTCTGATGCCTCACATAGATGCTTTTAAGCAGTCCCTGCAGGAGAAAATGACAGAAATTGGG
ATAAGAAGTGGCTGGAAATATGATAGCTGCAAAAAAAATTTCCTGATCCAGGAGATAAGTGCCATCCTCGGGGGCCTGGAGGACCACATC
CTCAGAAGGAAGAGGAGGATCTACGAGTCCCTCACTGCCTCTGTCCAGAGTGACCTGAAGCTCTGTTACGAAGAGGCAGCTCAGATCACG
GGCAAAAAAGCGTGTGAGCGGATGAAAGATGCCATCAGAAGAGGAGTGGACCGGCAGGTGGCTGAGGGCATGTTTGAAAGGGCCCAGGAA
AGGATGCAGCACCAGTTTCAGCAGCTGAAGACTGGAATCGTGGAGAAGGTGAAGGGCAGCATCACCACTATGCTGGCCCTTGCTTCGTCC
CAGGGGGATGGCCTCTACAAGGAGCTTGCAGATGTCGGGAGTGAATACAAGGAGATGGAGAAGCTGCACAGAAGCCTGAGGGAGGTCGCG
GAGAATGCACGGCTGAGGAAGGGCATGCAAGAATTCCTCCTAAGGGCATCCCCCAGCAAGGCTGGCCCCCCCGGGACATCACTGTAACTC
CTGGGGCTTAGTCCCAATGGATGAAAAATCAGCCCAGAGCCAGAGAATTAGAATTACTTTTTTTGTTCTTAAGAGACAAGATCTATCTAC
CTCTGTTGCCCAGGCTGGAGTGCAGTGGCACCATCACAGCTCACTGCAGCCTCGAACTCCTAGGCTCAAGCGATCCTCCAGCCTCAGCCT
CCAGAGCAGCTGGGGCTACAGGTACAGGCCACCACACCTGGGTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTGTGTCACCCA
GGCTGGAATGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGAAATTCTCTGCCTCAGCCTCCCAAGTAGCTGG
GATTATAGGCGACTGCCACCACACCCGGTTAATTTTTATATTTTTAGTAGAGACGGGGTTTCATCATCTTGGCCAGGCTGGTCCTGAACT
CCTGACCTCGTGATCCACCCATCTCTGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCGTGCCCGGCCCATACCTGGGTAATTTT
TTAATTTTTTGTGGAGATGGCATCTTGCTCTGTTGCCCAGGGTGGTCTCAAACTCCTGGCCTCAAGTGATTCTCTCCCACCTCAGTCTCT
TGTGCTAGGATTGCAGGCATGAGCCATTGTGCCTGGCTCAGAATTCTTTCTGTTTTGTGAAATCTAATAGAGGACATTTCTCAACTATTT
GGACTTTGCATGCAATATAAAACTAGTATGTTTACTGCATTTTATTTTATAGCCCCAAAGAGTCATCTTCAATACCTAATGGAGTTCTAA
AGCTTTAGGGCAAGAAACTTTTGCTTCCGCAAAAACATCTAAACATCGCTGGGCATGGTGGCTCACTCCCGTAATCCCAGCACTTTGGGA
GGCTGAGGCGGGCGGATCATGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAATACAAAAAATT
AGCCAGGCGTGGTAGCATGTGCCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCATAGGTTGCAG
TGAGCCAAGGTCGCGCCACTGCACTCCAGCCTGGACGACGGAGTGAGACTATGTCTCAAAAAAAAAAAAAAAAAAAGAAAAAGAAAAAAA
TATATATATATACACACACACACCCATACATAAAAAAACTTAAACATTATAGAAAAAACATTGCACGATATAAAACAAGCCATAAAAAGA
AATTCATCCTTCAATAAAGAAAAATATCTAAACGTTGAAAAACTTAAGTATTATGGAAAACATTGCAAAATAAAGCTTTTAGGAATCCAA

>100027_100027_2_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000374622_NUGGC_chr8_27905129_ENST00000413272_length(amino acids)=413AA_BP=19
MAEAEESPGDPGTASPRPLRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYVTEAFGLLLLTD
SFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSKGNQGFHQTLKAVCLKNGIYASRT
LARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALMPHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKR
RIYESLTASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTMLALASSQGDGL

--------------------------------------------------------------
>100027_100027_3_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000462683_NUGGC_chr8_27905129_ENST00000341513_length(transcript)=3337nt_BP=801nt
TTATCTTTTAAGTTATTGTCACAATAGTTACTCTCTTTTAGACCCTGAACATTTTCAGTACTTGCTCCAAATGGTTTAGCAACTTTTGAA
GTGGGATTAACAAGTTTGGCCAATGAAGCTTCTTCCCTGCCCACCGCCAGAGGTGCTGGAGAAAAGTAATCCTGGAGGGTCGGCGTGGAG
GCAGTAGAGAGGTTTATAAAAGTCAAGGAAGTGGGAAGAGGCTTGCGAGCAGCAGGAGAGGCGCAGAGTCAGAGGGGCAGGGGCGGCGGC
GGAGGGAGCAGGAGGTTGGGGCTTGAGCCCGTCATTCCGGCGCACGAAAACTTGAAGTCGCTCGGTAGCCGGGGAAGGGAAGGAAGAGAG
GCAGGCTCTTTCCTAGAGGTGCCGTGATCGAGGGTCTGGCACTCCAAGCCAACTCCTGAGAACGGGAAATGGGCGGGAGTCGGTGGGGTG
GAGAGGGCAGCCGTGGTCGCGAGAGCGAAGGAGCGGTCTGAGAATCCGGCTTGAGTGTTAAAGGCTAAGCGTGTCTAGCTGGACCCGTGG
CCCCGAAGAAGCGAGACAAGGCGACGCGGAGCTGTCCCTGACACCCCGAGGACCGAGGGACAGCGAAGGGCCGGGGCCGCCGGCCATTGC
CAGGCGCCATTAGGTGACGCGGCCGTCACGCGATGACGCGCTGACCGGCAGTGGCCTCCACGTCGCAGGTTCCGCAAAGACCTGTGGGAG
CGACCCGGGAGAAGGAGGGCCAAGATGGCGGAAGCGGAGGAGTCTCCAGGAGACCCGGGGACAGCATCGCCCAGGCCCCTGAGAAAACTG
CCAGCTGACTTCAAGGTTCTGGAAGCCTCAGATCTGGTGTATACAGTCAGCGCCCAGGAGTACTGGCAGCAGGCTCTCCTCACCGAGGAG
GAAACGGAAATCCCTAAGTTAAGAGAATACATCAGGAAGAGCCTCTTGGACAAGAAGAAGAGGACAGTGACCAAGTATGTGACTGAAGCC
TTTGGCCTGTTGCTCCTCACAGATAGTTTCAACTCCACGCAAAACCTGCCGAATGAACACTTGCACATGAGTGTCCTGCGGAGATTTGCG
GAAGAGAAGGTTGAGCTGCTGGAGAAGGCCATCGCACAGTGCTTCGCCTGCATGGAGCAGCCTCTGCAAGAAGGGGTCAGGACCGCCAGG
ACTTCTTACCGCTGCATCCTCAGAGCATGCTTGGTGAGGAGTAAAGGAAACCAAGGTTTTCATCAGACCCTGAAAGCTGTTTGCCTGAAA
AATGGCATCTATGCCTCCAGGACTCTGGCGAGAATTGATCTAAATGAAGCCCTCACTCAGCCCGTCTATGACCAGATCGACCCTGTTTTT
GGAAGCATTTTTAGGACGGGGAAGCCCACTGGTTCAGCTCTGATGCCTCACATAGATGCTTTTAAGCAGTCCCTGCAGGAGAAAATGACA
GAAATTGGGATAAGAAGTGGCTGGAAATATGATAGCTGCAAAAAAAATTTCCTGATCCAGGAGATAAGTGCCATCCTCGGGGGCCTGGAG
GACCACATCCTCAGAAGGAAGAGGAGGATCTACGAGTCCCTCACTGCCTCTGTCCAGAGTGACCTGAAGCTCTGTTACGAAGAGGCAGCT
CAGATCACGGGCAAAAAAGCGTGTGAGCGGATGAAAGATGCCATCAGAAGAGGAGTGGACCGGCAGGTGGCTGAGGGCATGTTTGAAAGG
GCCCAGGAAAGGATGCAGCACCAGTTTCAGCAGCTGAAGACTGGAATCGTGGAGAAGGTGAAGGGCAGCATCACCACTATGCTGGCCCTT
GCTTCGTCCCAGGGGGATGGCCTCTACAAGGAGCTTGCAGATGTCGGGAGTGAATACAAGGAGATGGAGAAGCTGCACAGAAGCCTGAGG
GAGGTCGCGGAGAATGCACGGCTGAGGAAGGGCATGCAAGAATTCCTCCTAAGGGCATCCCCCAGCAAGGCTGGCCCCCCCGGGACATCA
CTGTAACTCCTGGGGCTTAGTCCCAATGGATGAAAAATCAGCCCAGAGCCAGAGAATTAGAATTACTTTTTTTGTTCTTAAGAGACAAGA
TCTATCTACCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACCATCACAGCTCACTGCAGCCTCGAACTCCTAGGCTCAAGCGATCCTCCAG
CCTCAGCCTCCAGAGCAGCTGGGGCTACAGGTACAGGCCACCACACCTGGGTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTG
TGTCACCCAGGCTGGAATGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGAAATTCTCTGCCTCAGCCTCCCA
AGTAGCTGGGATTATAGGCGACTGCCACCACACCCGGTTAATTTTTATATTTTTAGTAGAGACGGGGTTTCATCATCTTGGCCAGGCTGG
TCCTGAACTCCTGACCTCGTGATCCACCCATCTCTGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCGTGCCCGGCCCATACCTG
GGTAATTTTTTAATTTTTTGTGGAGATGGCATCTTGCTCTGTTGCCCAGGGTGGTCTCAAACTCCTGGCCTCAAGTGATTCTCTCCCACC
TCAGTCTCTTGTGCTAGGATTGCAGGCATGAGCCATTGTGCCTGGCTCAGAATTCTTTCTGTTTTGTGAAATCTAATAGAGGACATTTCT
CAACTATTTGGACTTTGCATGCAATATAAAACTAGTATGTTTACTGCATTTTATTTTATAGCCCCAAAGAGTCATCTTCAATACCTAATG
GAGTTCTAAAGCTTTAGGGCAAGAAACTTTTGCTTCCGCAAAAACATCTAAACATCGCTGGGCATGGTGGCTCACTCCCGTAATCCCAGC
ACTTTGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAATA
CAAAAAATTAGCCAGGCGTGGTAGCATGTGCCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAT
AGGTTGCAGTGAGCCAAGGTCGCGCCACTGCACTCCAGCCTGGACGACGGAGTGAGACTATGTCTCAAAAAAAAAAAAAAAAAAAGAAAA
AGAAAAAAATATATATATATACACACACACACCCATACATAAAAAAACTTAAACATTATAGAAAAAACATTGCACGATATAAAACAAGCC
ATAAAAAGAAATTCATCCTTCAATAAAGAAAAATATCTAAACGTTGAAAAACTTAAGTATTATGGAAAACATTGCAAAATAAAGCTTTTA

>100027_100027_3_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000462683_NUGGC_chr8_27905129_ENST00000341513_length(amino acids)=424AA_BP=30
MWERPGRRRAKMAEAEESPGDPGTASPRPLRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYV
TEAFGLLLLTDSFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSKGNQGFHQTLKAV
CLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALMPHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILG
GLEDHILRRKRRIYESLTASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTM

--------------------------------------------------------------
>100027_100027_4_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000462683_NUGGC_chr8_27905129_ENST00000413272_length(transcript)=3339nt_BP=801nt
TTATCTTTTAAGTTATTGTCACAATAGTTACTCTCTTTTAGACCCTGAACATTTTCAGTACTTGCTCCAAATGGTTTAGCAACTTTTGAA
GTGGGATTAACAAGTTTGGCCAATGAAGCTTCTTCCCTGCCCACCGCCAGAGGTGCTGGAGAAAAGTAATCCTGGAGGGTCGGCGTGGAG
GCAGTAGAGAGGTTTATAAAAGTCAAGGAAGTGGGAAGAGGCTTGCGAGCAGCAGGAGAGGCGCAGAGTCAGAGGGGCAGGGGCGGCGGC
GGAGGGAGCAGGAGGTTGGGGCTTGAGCCCGTCATTCCGGCGCACGAAAACTTGAAGTCGCTCGGTAGCCGGGGAAGGGAAGGAAGAGAG
GCAGGCTCTTTCCTAGAGGTGCCGTGATCGAGGGTCTGGCACTCCAAGCCAACTCCTGAGAACGGGAAATGGGCGGGAGTCGGTGGGGTG
GAGAGGGCAGCCGTGGTCGCGAGAGCGAAGGAGCGGTCTGAGAATCCGGCTTGAGTGTTAAAGGCTAAGCGTGTCTAGCTGGACCCGTGG
CCCCGAAGAAGCGAGACAAGGCGACGCGGAGCTGTCCCTGACACCCCGAGGACCGAGGGACAGCGAAGGGCCGGGGCCGCCGGCCATTGC
CAGGCGCCATTAGGTGACGCGGCCGTCACGCGATGACGCGCTGACCGGCAGTGGCCTCCACGTCGCAGGTTCCGCAAAGACCTGTGGGAG
CGACCCGGGAGAAGGAGGGCCAAGATGGCGGAAGCGGAGGAGTCTCCAGGAGACCCGGGGACAGCATCGCCCAGGCCCCTGAGAAAACTG
CCAGCTGACTTCAAGGTTCTGGAAGCCTCAGATCTGGTGTATACAGTCAGCGCCCAGGAGTACTGGCAGCAGGCTCTCCTCACCGAGGAG
GAAACGGAAATCCCTAAGTTAAGAGAATACATCAGGAAGAGCCTCTTGGACAAGAAGAAGAGGACAGTGACCAAGTATGTGACTGAAGCC
TTTGGCCTGTTGCTCCTCACAGATAGTTTCAACTCCACGCAAAACCTGCCGAATGAACACTTGCACATGAGTGTCCTGCGGAGATTTGCG
GAAGAGAAGGTTGAGCTGCTGGAGAAGGCCATCGCACAGTGCTTCGCCTGCATGGAGCAGCCTCTGCAAGAAGGGGTCAGGACCGCCAGG
ACTTCTTACCGCTGCATCCTCAGAGCATGCTTGGTGAGGAGTAAAGGAAACCAAGGTTTTCATCAGACCCTGAAAGCTGTTTGCCTGAAA
AATGGCATCTATGCCTCCAGGACTCTGGCGAGAATTGATCTAAATGAAGCCCTCACTCAGCCCGTCTATGACCAGATCGACCCTGTTTTT
GGAAGCATTTTTAGGACGGGGAAGCCCACTGGTTCAGCTCTGATGCCTCACATAGATGCTTTTAAGCAGTCCCTGCAGGAGAAAATGACA
GAAATTGGGATAAGAAGTGGCTGGAAATATGATAGCTGCAAAAAAAATTTCCTGATCCAGGAGATAAGTGCCATCCTCGGGGGCCTGGAG
GACCACATCCTCAGAAGGAAGAGGAGGATCTACGAGTCCCTCACTGCCTCTGTCCAGAGTGACCTGAAGCTCTGTTACGAAGAGGCAGCT
CAGATCACGGGCAAAAAAGCGTGTGAGCGGATGAAAGATGCCATCAGAAGAGGAGTGGACCGGCAGGTGGCTGAGGGCATGTTTGAAAGG
GCCCAGGAAAGGATGCAGCACCAGTTTCAGCAGCTGAAGACTGGAATCGTGGAGAAGGTGAAGGGCAGCATCACCACTATGCTGGCCCTT
GCTTCGTCCCAGGGGGATGGCCTCTACAAGGAGCTTGCAGATGTCGGGAGTGAATACAAGGAGATGGAGAAGCTGCACAGAAGCCTGAGG
GAGGTCGCGGAGAATGCACGGCTGAGGAAGGGCATGCAAGAATTCCTCCTAAGGGCATCCCCCAGCAAGGCTGGCCCCCCCGGGACATCA
CTGTAACTCCTGGGGCTTAGTCCCAATGGATGAAAAATCAGCCCAGAGCCAGAGAATTAGAATTACTTTTTTTGTTCTTAAGAGACAAGA
TCTATCTACCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACCATCACAGCTCACTGCAGCCTCGAACTCCTAGGCTCAAGCGATCCTCCAG
CCTCAGCCTCCAGAGCAGCTGGGGCTACAGGTACAGGCCACCACACCTGGGTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTG
TGTCACCCAGGCTGGAATGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGAAATTCTCTGCCTCAGCCTCCCA
AGTAGCTGGGATTATAGGCGACTGCCACCACACCCGGTTAATTTTTATATTTTTAGTAGAGACGGGGTTTCATCATCTTGGCCAGGCTGG
TCCTGAACTCCTGACCTCGTGATCCACCCATCTCTGCCTCCCAAAGTGCTGGGATTACGGGCATGAGCCACCGTGCCCGGCCCATACCTG
GGTAATTTTTTAATTTTTTGTGGAGATGGCATCTTGCTCTGTTGCCCAGGGTGGTCTCAAACTCCTGGCCTCAAGTGATTCTCTCCCACC
TCAGTCTCTTGTGCTAGGATTGCAGGCATGAGCCATTGTGCCTGGCTCAGAATTCTTTCTGTTTTGTGAAATCTAATAGAGGACATTTCT
CAACTATTTGGACTTTGCATGCAATATAAAACTAGTATGTTTACTGCATTTTATTTTATAGCCCCAAAGAGTCATCTTCAATACCTAATG
GAGTTCTAAAGCTTTAGGGCAAGAAACTTTTGCTTCCGCAAAAACATCTAAACATCGCTGGGCATGGTGGCTCACTCCCGTAATCCCAGC
ACTTTGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAATA
CAAAAAATTAGCCAGGCGTGGTAGCATGTGCCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAT
AGGTTGCAGTGAGCCAAGGTCGCGCCACTGCACTCCAGCCTGGACGACGGAGTGAGACTATGTCTCAAAAAAAAAAAAAAAAAAAGAAAA
AGAAAAAAATATATATATATACACACACACACCCATACATAAAAAAACTTAAACATTATAGAAAAAACATTGCACGATATAAAACAAGCC
ATAAAAAGAAATTCATCCTTCAATAAAGAAAAATATCTAAACGTTGAAAAACTTAAGTATTATGGAAAACATTGCAAAATAAAGCTTTTA

>100027_100027_4_YIPF6-NUGGC_YIPF6_chrX_67718965_ENST00000462683_NUGGC_chr8_27905129_ENST00000413272_length(amino acids)=424AA_BP=30
MWERPGRRRAKMAEAEESPGDPGTASPRPLRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYV
TEAFGLLLLTDSFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSKGNQGFHQTLKAV
CLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALMPHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILG
GLEDHILRRKRRIYESLTASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for YIPF6-NUGGC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for YIPF6-NUGGC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for YIPF6-NUGGC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source