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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:YWHAB-STK4 (FusionGDB2 ID:100124)

Fusion Gene Summary for YWHAB-STK4

check button Fusion gene summary
Fusion gene informationFusion gene name: YWHAB-STK4
Fusion gene ID: 100124
HgeneTgene
Gene symbol

YWHAB

STK4

Gene ID

7529

6789

Gene nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaserine/threonine kinase 4
SynonymsGW128|HEL-S-1|HS1|KCIP-1|YWHAAKRS2|MST1|YSK3
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Description14-3-3 protein beta/alpha14-3-3 alphabrain protein 14-3-3, beta isoformepididymis secretory protein Li 1protein 1054protein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptidetyrosinserine/threonine-protein kinase 4STE20-like kinase MST1kinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2
Modification date2020032720200313
UniProtAcc.

Q13043

Ensembl transtripts involved in fusion geneENST00000479421, ENST00000353703, 
ENST00000372839, 		ENST00000372801, 
ENST00000372806, ENST00000396731, 
ENST00000499879, ENST00000487587, 
Fusion gene scores* DoF score16 X 16 X 6=153613 X 13 X 7=1183
# samples 2716
** MAII scorelog2(27/1536*10)=-2.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1183*10)=-2.88630626345243
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YWHAB [Title/Abstract] AND STK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTK4(43653771)-YWHAB(43530171), # samples:1
YWHAB(43514527)-STK4(43615773), # samples:2
YWHAB(43514527)-STK4(43703659), # samples:2
YWHAB(43514527)-STK4(43703658), # samples:2
YWHAB(43516383)-STK4(43703658), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYWHAB

GO:0035308

negative regulation of protein dephosphorylation

17255105

HgeneYWHAB

GO:0043085

positive regulation of catalytic activity

17255105

HgeneYWHAB

GO:0051220

cytoplasmic sequestering of protein

10869435

TgeneSTK4

GO:0000902

cell morphogenesis

11805089

TgeneSTK4

GO:0001934

positive regulation of protein phosphorylation

19962960

TgeneSTK4

GO:0006468

protein phosphorylation

8566796|11805089

TgeneSTK4

GO:0006915

apoptotic process

21212262

TgeneSTK4

GO:0018105

peptidyl-serine phosphorylation

16751106

TgeneSTK4

GO:0032092

positive regulation of protein binding

22292086

TgeneSTK4

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19962960

TgeneSTK4

GO:0035329

hippo signaling

20412773

TgeneSTK4

GO:0035556

intracellular signal transduction

8566796

TgeneSTK4

GO:0043065

positive regulation of apoptotic process

15109305

TgeneSTK4

GO:0046777

protein autophosphorylation

11805089

TgeneSTK4

GO:0050821

protein stabilization

19962960


check buttonFusion gene breakpoints across YWHAB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across STK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09A-01AYWHABchr20

43514527

+STK4chr20

43615773

+
ChimerDB4BRCATCGA-A8-A09AYWHABchr20

43514527

+STK4chr20

43615772

+
ChimerDB4ESCATCGA-VR-A8ET-01AYWHABchr20

43514527

+STK4chr20

43703659

+
ChimerDB4ESCATCGA-VR-A8ETYWHABchr20

43514527

+STK4chr20

43703658

+
ChimerDB4ESCATCGA-VR-A8ETYWHABchr20

43514527

+STK4chr20

43703659

+
ChimerDB4ESCATCGA-VR-A8ETYWHABchr20

43516383

+STK4chr20

43703658

+


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Fusion Gene ORF analysis for YWHAB-STK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479421ENST00000372801YWHABchr20

43514527

+STK4chr20

43615773

+
3UTR-3CDSENST00000479421ENST00000372801YWHABchr20

43514527

+STK4chr20

43615772

+
3UTR-3CDSENST00000479421ENST00000372806YWHABchr20

43514527

+STK4chr20

43615773

+
3UTR-3CDSENST00000479421ENST00000372806YWHABchr20

43514527

+STK4chr20

43615772

+
3UTR-3CDSENST00000479421ENST00000372806YWHABchr20

43514527

+STK4chr20

43703659

+
3UTR-3CDSENST00000479421ENST00000372806YWHABchr20

43514527

+STK4chr20

43703658

+
3UTR-3CDSENST00000479421ENST00000396731YWHABchr20

43514527

+STK4chr20

43615773

+
3UTR-3CDSENST00000479421ENST00000396731YWHABchr20

43514527

+STK4chr20

43615772

+
3UTR-3UTRENST00000479421ENST00000372801YWHABchr20

43514527

+STK4chr20

43703659

+
3UTR-3UTRENST00000479421ENST00000372801YWHABchr20

43514527

+STK4chr20

43703658

+
3UTR-3UTRENST00000479421ENST00000499879YWHABchr20

43514527

+STK4chr20

43703659

+
3UTR-3UTRENST00000479421ENST00000499879YWHABchr20

43514527

+STK4chr20

43703658

+
3UTR-intronENST00000479421ENST00000396731YWHABchr20

43514527

+STK4chr20

43703659

+
3UTR-intronENST00000479421ENST00000396731YWHABchr20

43514527

+STK4chr20

43703658

+
3UTR-intronENST00000479421ENST00000487587YWHABchr20

43514527

+STK4chr20

43615773

+
3UTR-intronENST00000479421ENST00000487587YWHABchr20

43514527

+STK4chr20

43615772

+
3UTR-intronENST00000479421ENST00000487587YWHABchr20

43514527

+STK4chr20

43703659

+
3UTR-intronENST00000479421ENST00000487587YWHABchr20

43514527

+STK4chr20

43703658

+
3UTR-intronENST00000479421ENST00000499879YWHABchr20

43514527

+STK4chr20

43615773

+
3UTR-intronENST00000479421ENST00000499879YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-3CDSENST00000353703ENST00000372801YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-3CDSENST00000353703ENST00000372801YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-3CDSENST00000353703ENST00000372806YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-3CDSENST00000353703ENST00000372806YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-3CDSENST00000353703ENST00000372806YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-3CDSENST00000353703ENST00000372806YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-3CDSENST00000353703ENST00000396731YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-3CDSENST00000353703ENST00000396731YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-3CDSENST00000372839ENST00000372801YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-3CDSENST00000372839ENST00000372801YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-3CDSENST00000372839ENST00000372806YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-3CDSENST00000372839ENST00000372806YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-3CDSENST00000372839ENST00000372806YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-3CDSENST00000372839ENST00000372806YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-3CDSENST00000372839ENST00000372806YWHABchr20

43516383

+STK4chr20

43703658

+
5UTR-3CDSENST00000372839ENST00000396731YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-3CDSENST00000372839ENST00000396731YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-3UTRENST00000353703ENST00000372801YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-3UTRENST00000353703ENST00000372801YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-3UTRENST00000353703ENST00000499879YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-3UTRENST00000353703ENST00000499879YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-3UTRENST00000372839ENST00000372801YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-3UTRENST00000372839ENST00000372801YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-3UTRENST00000372839ENST00000372801YWHABchr20

43516383

+STK4chr20

43703658

+
5UTR-3UTRENST00000372839ENST00000499879YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-3UTRENST00000372839ENST00000499879YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-3UTRENST00000372839ENST00000499879YWHABchr20

43516383

+STK4chr20

43703658

+
5UTR-intronENST00000353703ENST00000396731YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-intronENST00000353703ENST00000396731YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-intronENST00000353703ENST00000487587YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-intronENST00000353703ENST00000487587YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-intronENST00000353703ENST00000487587YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-intronENST00000353703ENST00000487587YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-intronENST00000353703ENST00000499879YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-intronENST00000353703ENST00000499879YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-intronENST00000372839ENST00000396731YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-intronENST00000372839ENST00000396731YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-intronENST00000372839ENST00000396731YWHABchr20

43516383

+STK4chr20

43703658

+
5UTR-intronENST00000372839ENST00000487587YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-intronENST00000372839ENST00000487587YWHABchr20

43514527

+STK4chr20

43615772

+
5UTR-intronENST00000372839ENST00000487587YWHABchr20

43514527

+STK4chr20

43703659

+
5UTR-intronENST00000372839ENST00000487587YWHABchr20

43514527

+STK4chr20

43703658

+
5UTR-intronENST00000372839ENST00000487587YWHABchr20

43516383

+STK4chr20

43703658

+
5UTR-intronENST00000372839ENST00000499879YWHABchr20

43514527

+STK4chr20

43615773

+
5UTR-intronENST00000372839ENST00000499879YWHABchr20

43514527

+STK4chr20

43615772

+
intron-3CDSENST00000353703ENST00000372806YWHABchr20

43516383

+STK4chr20

43703658

+
intron-3CDSENST00000479421ENST00000372806YWHABchr20

43516383

+STK4chr20

43703658

+
intron-3UTRENST00000353703ENST00000372801YWHABchr20

43516383

+STK4chr20

43703658

+
intron-3UTRENST00000353703ENST00000499879YWHABchr20

43516383

+STK4chr20

43703658

+
intron-3UTRENST00000479421ENST00000372801YWHABchr20

43516383

+STK4chr20

43703658

+
intron-3UTRENST00000479421ENST00000499879YWHABchr20

43516383

+STK4chr20

43703658

+
intron-intronENST00000353703ENST00000396731YWHABchr20

43516383

+STK4chr20

43703658

+
intron-intronENST00000353703ENST00000487587YWHABchr20

43516383

+STK4chr20

43703658

+
intron-intronENST00000479421ENST00000396731YWHABchr20

43516383

+STK4chr20

43703658

+
intron-intronENST00000479421ENST00000487587YWHABchr20

43516383

+STK4chr20

43703658

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for YWHAB-STK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
YWHABchr2043514527+STK4chr2043615772+6.82E-070.9999993
YWHABchr2043514527+STK4chr2043615772+6.82E-070.9999993
YWHABchr2043516383+STK4chr2043703658+9.06E-080.9999999
YWHABchr2043514527+STK4chr2043703658+3.86E-111
YWHABchr2043514527+STK4chr2043703658+3.86E-111
YWHABchr2043514527+STK4chr2043615772+6.82E-070.9999993
YWHABchr2043514527+STK4chr2043615772+6.82E-070.9999993
YWHABchr2043516383+STK4chr2043703658+9.06E-080.9999999
YWHABchr2043514527+STK4chr2043703658+3.86E-111
YWHABchr2043514527+STK4chr2043703658+3.86E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for YWHAB-STK4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43653771/:43530171)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.STK4

Q13043

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for YWHAB-STK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for YWHAB-STK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for YWHAB-STK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for YWHAB-STK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource