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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:YWHAE-TXLNB (FusionGDB2 ID:100162)

Fusion Gene Summary for YWHAE-TXLNB

Fusion gene summary

Fusion gene information	Fusion gene name: YWHAE-TXLNB
	Fusion gene ID: 100162
		Hgene	Tgene
	Gene symbol	YWHAE	TXLNB
	Gene ID	7531	167838
	Gene name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	taxilin beta
	Synonyms	14-3-3E\|HEL2\|KCIP-1\|MDCR\|MDS	C6orf198\|LST001\|MDP77\|dJ522B19.2
	Cytomap	17p13.3	6q24.1
	Type of gene	protein-coding	protein-coding
	Description	14-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine	beta-taxilinmuscle-derived protein 77
	Modification date	20200327	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000498643, ENST00000571732, ENST00000264335, ENST00000573026, ENST00000575977,	ENST00000358430,
Fusion gene scores	* DoF score	28 X 9 X 15=3780	4 X 4 X 2=32
	# samples	42	4
	** MAII score	log2(42/3780*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: YWHAE [Title/Abstract] AND TXLNB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	YWHAE(1303341)-TXLNB(139569046), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	YWHAE	GO:0000165	MAPK cascade	12917326
Hgene	YWHAE	GO:0034605	cellular response to heat	12917326
Hgene	YWHAE	GO:0046827	positive regulation of protein export from nucleus	12917326
Hgene	YWHAE	GO:0051480	regulation of cytosolic calcium ion concentration	18029012
Hgene	YWHAE	GO:0060306	regulation of membrane repolarization	11953308
Hgene	YWHAE	GO:1901016	regulation of potassium ion transmembrane transporter activity	11953308
Hgene	YWHAE	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	18029012
Hgene	YWHAE	GO:1902309	negative regulation of peptidyl-serine dephosphorylation	11953308
Hgene	YWHAE	GO:1905913	negative regulation of calcium ion export across plasma membrane	18029012

Fusion gene breakpoints across YWHAE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TXLNB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EB-A6L9-06A	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-

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Fusion Gene ORF analysis for YWHAE-TXLNB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000498643	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-
5UTR-3CDS	ENST00000571732	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-
In-frame	ENST00000264335	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-
In-frame	ENST00000573026	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-
In-frame	ENST00000575977	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264335	YWHAE	chr17	1303341	-	ENST00000358430	TXLNB	chr6	139569046	-	3775	332	248	1309	353
ENST00000573026	YWHAE	chr17	1303341	-	ENST00000358430	TXLNB	chr6	139569046	-	3578	135	51	1112	353
ENST00000575977	YWHAE	chr17	1303341	-	ENST00000358430	TXLNB	chr6	139569046	-	3611	168	84	1145	353

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264335	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-	0.001061149	0.99893886
ENST00000573026	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-	0.001070652	0.9989293
ENST00000575977	ENST00000358430	YWHAE	chr17	1303341	-	TXLNB	chr6	139569046	-	0.001046439	0.9989536

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Fusion Genomic Features for YWHAE-TXLNB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for YWHAE-TXLNB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1303341/chr6:139569046)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TXLNB

chr17:1303341

chr6:139569046

ENST00000358430

378_467

359

685.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TXLNB

chr17:1303341

chr6:139569046

ENST00000358430

135_351

359

685.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for YWHAE-TXLNB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>100162_100162_1_YWHAE-TXLNB_YWHAE_chr17_1303341_ENST00000264335_TXLNB_chr6_139569046_ENST00000358430_length(transcript)=3775nt_BP=332nt
GCTCCGGCGCCCGCTGAGCCGACAGAGGAGAGGCGTCTCGTGCGCTCGTTCCAGCCGCTTCGGGCGCCGAGTTCCAGGACCCGCCCCCCG
CGCCAGTTGCCAGGGAGCGGTTGCCATAGAGCTGAGCAGTTGTCCGCGTGCGCAGGCGGAAGTCCCGGATTGAGGCGCCGCCATTTTTGC
TGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACCCTGCCGGAGCCGCTGCCGCTAT
GGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGCTCACTCTCTACTCAGGAAGGTTTGAAG
AATTCCAGAGCACACTAACTAAAAGCAACGAGGTGTTTGCCACGTTCAAACAGGAAATGGACAAAACAACTAAGAAAATGAAGAAGCTGG
AAAAGGACACAGCCACATGGAAAGCCCGATTTGAGAACTGTAACAAAGCTCTGTTGGACATGATTGAAGAGAAAGCACTGAGAGCTAAAG
AATATGAGTGCTTTGTGATGAAAATCGGGAGGCTAGAGAACCTCTGCCGTGCTTTACAAGAAGAGAGAAACGAACTCCACAAAAAAATCA
GAGACGCAGAAATATCTGAAAAGGATGACCAAAGTCAGCACAACTCCGATGAAGAGCCAGAGTCAAACGTCTCTGTGGATCAAGAGATTG
ACGCAGAGGAGGTTAATAGTGTCCAAACCGCCGTGAAAAATCTGGCCACAGCCTTCATGATAATTCATCATCCAGAGTCAACCCCGCACC
AGTCCAAAGAAACCCAACCCGAAATAGGCAGTTCTCAGGAGAGTGCTGACGCCGCTCTCAAGGAGCCAGAGCAACCCCCTCTGATCCCTT
CACGGGATTCAGAGAGTCCCCTGCCTCCCCTAACTCCTCAGGCTGAAGCCGAAGGAGGCAGTGATGCTGAACCTCCCTCCAAGGCCAGTA
ATTCTCCTGCCGGGTTGGGAGCAGAAACCCAATGCGAGGGTCTCCCTGTTGGAGCACAGGCTGATCAGGCGTCCTGGAAGCCAGAGGCAG
AAGCTTCCGGTCAGGCCCCACAGGCTCCCACCGAGGCCTCCCTACAGAAGATGGAGGCAGATGTGCCTGCTCCAGCATGCGCAGCAGAAG
AGCACGTTGCAGCCATGGTGCCTGCATGCGAGCCCAGTAGGCAGCCCCCACGAGCAGCAGCAGAGGAGCTGCCAGTAGGGGCCTCAGCTG
GGCCCCAGCCGCGCAACGTGGCTGACACCAATCTGGAAGGCGTCGACTAAGCCTCACCGTGCCTTCAGAGGCTTCTTCCTGCCTCTTTGC
ATATTCAGCATAACAGCTTGTCTTCCGAAAAAGGCATTAAGGGCTAGAGATGTCAAATGGAAGAGACTTAGGATCAAGACATTTTTTAAT
GTTAGGCAGAACACATTCATTCAGACTTTGCTATTTGTTGTCAATTTATAGCTGATTTGAAGGTTTTCTATTTAACACTGGTTGACAGTA
TAATTTTCCCAAAGGGCAACAAAACATACAGATAGCAAATTTATATTCCTTTTCTGTTAAGATAATACTTAAATTTGTTAATCACCAGTA
AGATTTGATGTTTAAAGACTTCCACTGCAATATATAAATACTGAAAATGTGATGTTCTGCTTATTTGGATATATAGTTTAACAAGTTCCA
TAGTAATTTATGGATGCCCAGGTTACATTTAAACTATACATATACATAATATATACATACGTGTGTACTTATTATATGTATATATACACG
TATGTATAGATGTGTGAATATTTGTTTATATACATATATGCACGTATCTATATGTATATATAAATGCATTATTACACATACATTTCTCTC
ACCCCTTAATGCATTTTTCTCAATGCAGAATATTTAGATGCTAATCAAAAAAATGATCTCTTACTTGCACTTGAGACTATGGTTGACTAA
TGCTCTATAAATCCGAAGAGAGTTCGGACTATAAGTATTTAGGCTATCATTATGTTGGGCAAAAATAAGTAACCCAATGGTAGATAAATG
AATTCAACCAGTTGATCAAATGGCAGAAAAGCAGTTAGACTACAATCTGTGCAGACAGCATGGACACAAAGATGACCACAAGGGGCCCAA
AACAGAAAAGAGAAACACAAGCTCACCTCTTGGAGCTGCTTCTCCTACACTTCTCAGCCCATTGCTTTGCCACCCCCTCATGTGCCAGGG
CATCCCATTCCAGGCTTCCTGCAAGGAAACGGTTGGAAGTGGGAAAGGGGAGCTAGGGATTGAGGGGTTAAGGGACCTCACACTAAGAAG
GGGCTGTGCTTTGATCCCCTGCCTCTTGCACTACCAATGTCTCAAGACATAATATTCATCTCTTGCTGTCAGACCCATTCTATATTCTAA
AAGCTTCTGCTCCTTCCTTCCCAATTTCTCCTTTGTAGCAGGAAATTACACCCAGCCCTCATCTCAATTAATGCTAAATAAAGCTATTGT
TTTTCCAAAACACAAATCTACACTGGGTCTCAATATCAGTGATGAGGCTTACAAACCAACACGTTTTCTGCCATGAGGATTTCTCTTTAG
GCCAGAAGTACAAAACAAAAAAACCAATGGATTTTAACCAAAATGATTTGAAATATAGGTGAGGATTCAGGAGAAGGCAAAAGCTAGAAA
CACTTGGGGTTGTCAACATGAGTATTACATTAACATTGCTTGATGAGAACCTCTAATGATACTGACAACATAAATTACCTAGGGTAAAGG
ATAGCTGCAACAATGAAACAGGAAAGAAGAGAGGGAGAGAGAGGAAAGGGAAGGAAGAAAGGAAGGAGGGAGAAGGGAAGAAAGAAACAA
TGTCTAACCCAACCCTATCTTGAAAGTTGAACTCAAGTAGAAAAATGGATAGAAACAAAATTCTCTAGTACTCATCCAGGAAACCATTCT
TCAATGTTGCATGTGGCTGTTTGCCAAGGCACACAAAGTGCTTGTAGGCAGCAACCATATGCTACAAGAATTGTAAACTGCATACAGTTT
GTTTGAAGTAGACAGTGAGGATAATAACAAAGTTGCTAGGCAGGAAAAAAAATCAGGAAAAAAGCTTGTCGCTATTTGAGAATCTGTATA
TTTTTAAAGGCTTAAAATATTATAACCACAGGGTATCCAGCCAAATTCAACATTACTGCAAGTCTTAGAGATTTAAACATTCATTTGATT
CAGAGCTAAATATTCACCATAATCCAGGAGGGTCTCCTTCCCCACTGCAGAGGCAGAACGTCCAAGAATGGAGTAAGATTAGTCATAGTA
AAGTCTCAGTCTGAATATTTAGCAAGAGAAACAGGCAGCAGAGGAACCCAAAGGCAGTAAATCAAATATTCTAAAACCCAAAGTTCATTA
TTTTCATCCAAAAGACTTTCACAGAAACACATTACTCACAGCCATGTATATCTTGGACAGAGTTTCAGATGGAATGACTTGTCTGAAATT
TGTAAAGCTTAATATAGGTTTTGGGGGAATTATTTTAATATTCAAAGAATGTTTTATTATAGTCCTTTGTGTTAAAATTTAGCCTTACTA
ATTATAACAATAACTCATAAAGTTCTAAATTCAGAAGGAATGTCTGTTCTTTATCAAGTGTATGTAACTATTTTTTAGAAATGCCATCTA

>100162_100162_1_YWHAE-TXLNB_YWHAE_chr17_1303341_ENST00000264335_TXLNB_chr6_139569046_ENST00000358430_length(amino acids)=353AA_BP=28
MPEPLPLWMIERIWCTRRSWPSRLSDTTLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIE
EKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIH
HPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQ

--------------------------------------------------------------
>100162_100162_2_YWHAE-TXLNB_YWHAE_chr17_1303341_ENST00000573026_TXLNB_chr6_139569046_ENST00000358430_length(transcript)=3578nt_BP=135nt
AGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACCCTGCCGGAGCCGCTGCCGCTATGGATGATCGAGAGGATC
TGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGCTCACTCTCTACTCAGGAAGGTTTGAAGAATTCCAGAGCACACTA
ACTAAAAGCAACGAGGTGTTTGCCACGTTCAAACAGGAAATGGACAAAACAACTAAGAAAATGAAGAAGCTGGAAAAGGACACAGCCACA
TGGAAAGCCCGATTTGAGAACTGTAACAAAGCTCTGTTGGACATGATTGAAGAGAAAGCACTGAGAGCTAAAGAATATGAGTGCTTTGTG
ATGAAAATCGGGAGGCTAGAGAACCTCTGCCGTGCTTTACAAGAAGAGAGAAACGAACTCCACAAAAAAATCAGAGACGCAGAAATATCT
GAAAAGGATGACCAAAGTCAGCACAACTCCGATGAAGAGCCAGAGTCAAACGTCTCTGTGGATCAAGAGATTGACGCAGAGGAGGTTAAT
AGTGTCCAAACCGCCGTGAAAAATCTGGCCACAGCCTTCATGATAATTCATCATCCAGAGTCAACCCCGCACCAGTCCAAAGAAACCCAA
CCCGAAATAGGCAGTTCTCAGGAGAGTGCTGACGCCGCTCTCAAGGAGCCAGAGCAACCCCCTCTGATCCCTTCACGGGATTCAGAGAGT
CCCCTGCCTCCCCTAACTCCTCAGGCTGAAGCCGAAGGAGGCAGTGATGCTGAACCTCCCTCCAAGGCCAGTAATTCTCCTGCCGGGTTG
GGAGCAGAAACCCAATGCGAGGGTCTCCCTGTTGGAGCACAGGCTGATCAGGCGTCCTGGAAGCCAGAGGCAGAAGCTTCCGGTCAGGCC
CCACAGGCTCCCACCGAGGCCTCCCTACAGAAGATGGAGGCAGATGTGCCTGCTCCAGCATGCGCAGCAGAAGAGCACGTTGCAGCCATG
GTGCCTGCATGCGAGCCCAGTAGGCAGCCCCCACGAGCAGCAGCAGAGGAGCTGCCAGTAGGGGCCTCAGCTGGGCCCCAGCCGCGCAAC
GTGGCTGACACCAATCTGGAAGGCGTCGACTAAGCCTCACCGTGCCTTCAGAGGCTTCTTCCTGCCTCTTTGCATATTCAGCATAACAGC
TTGTCTTCCGAAAAAGGCATTAAGGGCTAGAGATGTCAAATGGAAGAGACTTAGGATCAAGACATTTTTTAATGTTAGGCAGAACACATT
CATTCAGACTTTGCTATTTGTTGTCAATTTATAGCTGATTTGAAGGTTTTCTATTTAACACTGGTTGACAGTATAATTTTCCCAAAGGGC
AACAAAACATACAGATAGCAAATTTATATTCCTTTTCTGTTAAGATAATACTTAAATTTGTTAATCACCAGTAAGATTTGATGTTTAAAG
ACTTCCACTGCAATATATAAATACTGAAAATGTGATGTTCTGCTTATTTGGATATATAGTTTAACAAGTTCCATAGTAATTTATGGATGC
CCAGGTTACATTTAAACTATACATATACATAATATATACATACGTGTGTACTTATTATATGTATATATACACGTATGTATAGATGTGTGA
ATATTTGTTTATATACATATATGCACGTATCTATATGTATATATAAATGCATTATTACACATACATTTCTCTCACCCCTTAATGCATTTT
TCTCAATGCAGAATATTTAGATGCTAATCAAAAAAATGATCTCTTACTTGCACTTGAGACTATGGTTGACTAATGCTCTATAAATCCGAA
GAGAGTTCGGACTATAAGTATTTAGGCTATCATTATGTTGGGCAAAAATAAGTAACCCAATGGTAGATAAATGAATTCAACCAGTTGATC
AAATGGCAGAAAAGCAGTTAGACTACAATCTGTGCAGACAGCATGGACACAAAGATGACCACAAGGGGCCCAAAACAGAAAAGAGAAACA
CAAGCTCACCTCTTGGAGCTGCTTCTCCTACACTTCTCAGCCCATTGCTTTGCCACCCCCTCATGTGCCAGGGCATCCCATTCCAGGCTT
CCTGCAAGGAAACGGTTGGAAGTGGGAAAGGGGAGCTAGGGATTGAGGGGTTAAGGGACCTCACACTAAGAAGGGGCTGTGCTTTGATCC
CCTGCCTCTTGCACTACCAATGTCTCAAGACATAATATTCATCTCTTGCTGTCAGACCCATTCTATATTCTAAAAGCTTCTGCTCCTTCC
TTCCCAATTTCTCCTTTGTAGCAGGAAATTACACCCAGCCCTCATCTCAATTAATGCTAAATAAAGCTATTGTTTTTCCAAAACACAAAT
CTACACTGGGTCTCAATATCAGTGATGAGGCTTACAAACCAACACGTTTTCTGCCATGAGGATTTCTCTTTAGGCCAGAAGTACAAAACA
AAAAAACCAATGGATTTTAACCAAAATGATTTGAAATATAGGTGAGGATTCAGGAGAAGGCAAAAGCTAGAAACACTTGGGGTTGTCAAC
ATGAGTATTACATTAACATTGCTTGATGAGAACCTCTAATGATACTGACAACATAAATTACCTAGGGTAAAGGATAGCTGCAACAATGAA
ACAGGAAAGAAGAGAGGGAGAGAGAGGAAAGGGAAGGAAGAAAGGAAGGAGGGAGAAGGGAAGAAAGAAACAATGTCTAACCCAACCCTA
TCTTGAAAGTTGAACTCAAGTAGAAAAATGGATAGAAACAAAATTCTCTAGTACTCATCCAGGAAACCATTCTTCAATGTTGCATGTGGC
TGTTTGCCAAGGCACACAAAGTGCTTGTAGGCAGCAACCATATGCTACAAGAATTGTAAACTGCATACAGTTTGTTTGAAGTAGACAGTG
AGGATAATAACAAAGTTGCTAGGCAGGAAAAAAAATCAGGAAAAAAGCTTGTCGCTATTTGAGAATCTGTATATTTTTAAAGGCTTAAAA
TATTATAACCACAGGGTATCCAGCCAAATTCAACATTACTGCAAGTCTTAGAGATTTAAACATTCATTTGATTCAGAGCTAAATATTCAC
CATAATCCAGGAGGGTCTCCTTCCCCACTGCAGAGGCAGAACGTCCAAGAATGGAGTAAGATTAGTCATAGTAAAGTCTCAGTCTGAATA
TTTAGCAAGAGAAACAGGCAGCAGAGGAACCCAAAGGCAGTAAATCAAATATTCTAAAACCCAAAGTTCATTATTTTCATCCAAAAGACT
TTCACAGAAACACATTACTCACAGCCATGTATATCTTGGACAGAGTTTCAGATGGAATGACTTGTCTGAAATTTGTAAAGCTTAATATAG
GTTTTGGGGGAATTATTTTAATATTCAAAGAATGTTTTATTATAGTCCTTTGTGTTAAAATTTAGCCTTACTAATTATAACAATAACTCA
TAAAGTTCTAAATTCAGAAGGAATGTCTGTTCTTTATCAAGTGTATGTAACTATTTTTTAGAAATGCCATCTACTTTCTAGAAACACTAA

>100162_100162_2_YWHAE-TXLNB_YWHAE_chr17_1303341_ENST00000573026_TXLNB_chr6_139569046_ENST00000358430_length(amino acids)=353AA_BP=28
MPEPLPLWMIERIWCTRRSWPSRLSDTTLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIE
EKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIH
HPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQ

--------------------------------------------------------------
>100162_100162_3_YWHAE-TXLNB_YWHAE_chr17_1303341_ENST00000575977_TXLNB_chr6_139569046_ENST00000358430_length(transcript)=3611nt_BP=168nt
GCGCCGCCATTTTTGCTGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACCCTGCCG
GAGCCGCTGCCGCTATGGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGCTCACTCTCTAC
TCAGGAAGGTTTGAAGAATTCCAGAGCACACTAACTAAAAGCAACGAGGTGTTTGCCACGTTCAAACAGGAAATGGACAAAACAACTAAG
AAAATGAAGAAGCTGGAAAAGGACACAGCCACATGGAAAGCCCGATTTGAGAACTGTAACAAAGCTCTGTTGGACATGATTGAAGAGAAA
GCACTGAGAGCTAAAGAATATGAGTGCTTTGTGATGAAAATCGGGAGGCTAGAGAACCTCTGCCGTGCTTTACAAGAAGAGAGAAACGAA
CTCCACAAAAAAATCAGAGACGCAGAAATATCTGAAAAGGATGACCAAAGTCAGCACAACTCCGATGAAGAGCCAGAGTCAAACGTCTCT
GTGGATCAAGAGATTGACGCAGAGGAGGTTAATAGTGTCCAAACCGCCGTGAAAAATCTGGCCACAGCCTTCATGATAATTCATCATCCA
GAGTCAACCCCGCACCAGTCCAAAGAAACCCAACCCGAAATAGGCAGTTCTCAGGAGAGTGCTGACGCCGCTCTCAAGGAGCCAGAGCAA
CCCCCTCTGATCCCTTCACGGGATTCAGAGAGTCCCCTGCCTCCCCTAACTCCTCAGGCTGAAGCCGAAGGAGGCAGTGATGCTGAACCT
CCCTCCAAGGCCAGTAATTCTCCTGCCGGGTTGGGAGCAGAAACCCAATGCGAGGGTCTCCCTGTTGGAGCACAGGCTGATCAGGCGTCC
TGGAAGCCAGAGGCAGAAGCTTCCGGTCAGGCCCCACAGGCTCCCACCGAGGCCTCCCTACAGAAGATGGAGGCAGATGTGCCTGCTCCA
GCATGCGCAGCAGAAGAGCACGTTGCAGCCATGGTGCCTGCATGCGAGCCCAGTAGGCAGCCCCCACGAGCAGCAGCAGAGGAGCTGCCA
GTAGGGGCCTCAGCTGGGCCCCAGCCGCGCAACGTGGCTGACACCAATCTGGAAGGCGTCGACTAAGCCTCACCGTGCCTTCAGAGGCTT
CTTCCTGCCTCTTTGCATATTCAGCATAACAGCTTGTCTTCCGAAAAAGGCATTAAGGGCTAGAGATGTCAAATGGAAGAGACTTAGGAT
CAAGACATTTTTTAATGTTAGGCAGAACACATTCATTCAGACTTTGCTATTTGTTGTCAATTTATAGCTGATTTGAAGGTTTTCTATTTA
ACACTGGTTGACAGTATAATTTTCCCAAAGGGCAACAAAACATACAGATAGCAAATTTATATTCCTTTTCTGTTAAGATAATACTTAAAT
TTGTTAATCACCAGTAAGATTTGATGTTTAAAGACTTCCACTGCAATATATAAATACTGAAAATGTGATGTTCTGCTTATTTGGATATAT
AGTTTAACAAGTTCCATAGTAATTTATGGATGCCCAGGTTACATTTAAACTATACATATACATAATATATACATACGTGTGTACTTATTA
TATGTATATATACACGTATGTATAGATGTGTGAATATTTGTTTATATACATATATGCACGTATCTATATGTATATATAAATGCATTATTA
CACATACATTTCTCTCACCCCTTAATGCATTTTTCTCAATGCAGAATATTTAGATGCTAATCAAAAAAATGATCTCTTACTTGCACTTGA
GACTATGGTTGACTAATGCTCTATAAATCCGAAGAGAGTTCGGACTATAAGTATTTAGGCTATCATTATGTTGGGCAAAAATAAGTAACC
CAATGGTAGATAAATGAATTCAACCAGTTGATCAAATGGCAGAAAAGCAGTTAGACTACAATCTGTGCAGACAGCATGGACACAAAGATG
ACCACAAGGGGCCCAAAACAGAAAAGAGAAACACAAGCTCACCTCTTGGAGCTGCTTCTCCTACACTTCTCAGCCCATTGCTTTGCCACC
CCCTCATGTGCCAGGGCATCCCATTCCAGGCTTCCTGCAAGGAAACGGTTGGAAGTGGGAAAGGGGAGCTAGGGATTGAGGGGTTAAGGG
ACCTCACACTAAGAAGGGGCTGTGCTTTGATCCCCTGCCTCTTGCACTACCAATGTCTCAAGACATAATATTCATCTCTTGCTGTCAGAC
CCATTCTATATTCTAAAAGCTTCTGCTCCTTCCTTCCCAATTTCTCCTTTGTAGCAGGAAATTACACCCAGCCCTCATCTCAATTAATGC
TAAATAAAGCTATTGTTTTTCCAAAACACAAATCTACACTGGGTCTCAATATCAGTGATGAGGCTTACAAACCAACACGTTTTCTGCCAT
GAGGATTTCTCTTTAGGCCAGAAGTACAAAACAAAAAAACCAATGGATTTTAACCAAAATGATTTGAAATATAGGTGAGGATTCAGGAGA
AGGCAAAAGCTAGAAACACTTGGGGTTGTCAACATGAGTATTACATTAACATTGCTTGATGAGAACCTCTAATGATACTGACAACATAAA
TTACCTAGGGTAAAGGATAGCTGCAACAATGAAACAGGAAAGAAGAGAGGGAGAGAGAGGAAAGGGAAGGAAGAAAGGAAGGAGGGAGAA
GGGAAGAAAGAAACAATGTCTAACCCAACCCTATCTTGAAAGTTGAACTCAAGTAGAAAAATGGATAGAAACAAAATTCTCTAGTACTCA
TCCAGGAAACCATTCTTCAATGTTGCATGTGGCTGTTTGCCAAGGCACACAAAGTGCTTGTAGGCAGCAACCATATGCTACAAGAATTGT
AAACTGCATACAGTTTGTTTGAAGTAGACAGTGAGGATAATAACAAAGTTGCTAGGCAGGAAAAAAAATCAGGAAAAAAGCTTGTCGCTA
TTTGAGAATCTGTATATTTTTAAAGGCTTAAAATATTATAACCACAGGGTATCCAGCCAAATTCAACATTACTGCAAGTCTTAGAGATTT
AAACATTCATTTGATTCAGAGCTAAATATTCACCATAATCCAGGAGGGTCTCCTTCCCCACTGCAGAGGCAGAACGTCCAAGAATGGAGT
AAGATTAGTCATAGTAAAGTCTCAGTCTGAATATTTAGCAAGAGAAACAGGCAGCAGAGGAACCCAAAGGCAGTAAATCAAATATTCTAA
AACCCAAAGTTCATTATTTTCATCCAAAAGACTTTCACAGAAACACATTACTCACAGCCATGTATATCTTGGACAGAGTTTCAGATGGAA
TGACTTGTCTGAAATTTGTAAAGCTTAATATAGGTTTTGGGGGAATTATTTTAATATTCAAAGAATGTTTTATTATAGTCCTTTGTGTTA
AAATTTAGCCTTACTAATTATAACAATAACTCATAAAGTTCTAAATTCAGAAGGAATGTCTGTTCTTTATCAAGTGTATGTAACTATTTT
TTAGAAATGCCATCTACTTTCTAGAAACACTAAAGTTATTGTTTTCTAAGTTAAATAACTATAATTTATATATCTATTAAAAAGGTACTT

>100162_100162_3_YWHAE-TXLNB_YWHAE_chr17_1303341_ENST00000575977_TXLNB_chr6_139569046_ENST00000358430_length(amino acids)=353AA_BP=28
MPEPLPLWMIERIWCTRRSWPSRLSDTTLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIE
EKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIH
HPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQ

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Top

Fusion Gene PPI Analysis for YWHAE-TXLNB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for YWHAE-TXLNB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for YWHAE-TXLNB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source