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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:YWHAH-SLC5A1 (FusionGDB2 ID:100188)

Fusion Gene Summary for YWHAH-SLC5A1

check button Fusion gene summary
Fusion gene informationFusion gene name: YWHAH-SLC5A1
Fusion gene ID: 100188
HgeneTgene
Gene symbol

YWHAH

SLC5A1

Gene ID

7533

6523

Gene nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etasolute carrier family 5 member 1
SynonymsYWHA1D22S675|NAGT|SGLT1
Cytomap

22q12.3

22q12.3

Type of geneprotein-codingprotein-coding
Description14-3-3 protein eta14-3-3 etatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptidesodium/glucose cotransporter 1Na+/glucose cotransporter 1high affinity sodium-glucose cotransportersolute carrier family 5 (sodium/glucose cotransporter), member 1
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000248975, ENST00000397492, 
ENST00000471374, 
ENST00000543737, 
ENST00000266088, 
Fusion gene scores* DoF score11 X 8 X 6=5284 X 4 X 4=64
# samples 135
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YWHAH [Title/Abstract] AND SLC5A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC5A1(32446001)-YWHAH(32352126), # samples:3
YWHAH(32340806)-SLC5A1(32445930), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC5A1-YWHAH seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLC5A1-YWHAH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC5A1-YWHAH seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYWHAH

GO:0002028

regulation of sodium ion transport

16728661

HgeneYWHAH

GO:0006713

glucocorticoid catabolic process

15790729

HgeneYWHAH

GO:0042921

glucocorticoid receptor signaling pathway

15790729

HgeneYWHAH

GO:0045893

positive regulation of transcription, DNA-templated

15790729

HgeneYWHAH

GO:0086010

membrane depolarization during action potential

16728661

HgeneYWHAH

GO:2000649

regulation of sodium ion transmembrane transporter activity

16728661

TgeneSLC5A1

GO:1904659

glucose transmembrane transport

8836035


check buttonFusion gene breakpoints across YWHAH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC5A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1365-01AYWHAHchr22

32340806

+SLC5A1chr22

32445930

+


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Fusion Gene ORF analysis for YWHAH-SLC5A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000248975ENST00000543737YWHAHchr22

32340806

+SLC5A1chr22

32445930

+
5CDS-intronENST00000397492ENST00000543737YWHAHchr22

32340806

+SLC5A1chr22

32445930

+
In-frameENST00000248975ENST00000266088YWHAHchr22

32340806

+SLC5A1chr22

32445930

+
In-frameENST00000397492ENST00000266088YWHAHchr22

32340806

+SLC5A1chr22

32445930

+
intron-3CDSENST00000471374ENST00000266088YWHAHchr22

32340806

+SLC5A1chr22

32445930

+
intron-intronENST00000471374ENST00000543737YWHAHchr22

32340806

+SLC5A1chr22

32445930

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000248975YWHAHchr2232340806+ENST00000266088SLC5A1chr2232445930+50363602732219648
ENST00000397492YWHAHchr2232340806+ENST00000266088SLC5A1chr2232445930+49752992122158648

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248975ENST00000266088YWHAHchr2232340806+SLC5A1chr2232445930+0.0020874050.9979126
ENST00000397492ENST00000266088YWHAHchr2232340806+SLC5A1chr2232445930+0.0021206730.9978794

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Fusion Genomic Features for YWHAH-SLC5A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
YWHAHchr2232340806+SLC5A1chr2232445929+2.81E-060.99999714
YWHAHchr2232340806+SLC5A1chr2232445929+2.81E-060.99999714

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for YWHAH-SLC5A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:32446001/chr22:32352126)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015527_56345665.0IntramembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014527_5630538.0IntramembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015127_14245665.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015164_17845665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015202_20845665.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015230_27745665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015299_31345665.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015335_38045665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015402_42345665.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015445_45545665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015477_48445665.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015506_52645665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000026608801550_6445665.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015564_64345665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000026608801586_10545665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014127_1420538.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014164_1780538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST000005437370141_280538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014202_2080538.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014230_2770538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014299_3130538.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014335_3800538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014402_4230538.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014445_4550538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014477_4840538.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014506_5260538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000054373701450_640538.0Topological domainCytoplasmic
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014564_6430538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000054373701486_1050538.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015106_12645665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015143_16345665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015179_20145665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015209_22945665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015278_29845665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015314_33445665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015381_40145665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015424_44445665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015456_47645665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015485_50545665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000266088015644_66445665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000026608801565_8545665.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014106_1260538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014143_1630538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014179_2010538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014209_2290538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014278_2980538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000054373701429_490538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014314_3340538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014381_4010538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014424_4440538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014456_4760538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014485_5050538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST00000543737014644_6640538.0TransmembraneHelical
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000054373701465_850538.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC5A1chr22:32340806chr22:32445930ENST000002660880151_2845665.0Topological domainExtracellular
TgeneSLC5A1chr22:32340806chr22:32445930ENST0000026608801529_4945665.0TransmembraneHelical


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Fusion Gene Sequence for YWHAH-SLC5A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100188_100188_1_YWHAH-SLC5A1_YWHAH_chr22_32340806_ENST00000248975_SLC5A1_chr22_32445930_ENST00000266088_length(transcript)=5036nt_BP=360nt
GCAGGCGTCGTCCCGTCCTCCCATCCCCCAGCGCGGCCGCGTCTCCTCCCTCGGCGTTGTCCGCGGCGCGAGCCACAGCGCGCGGGGCGA
GCCAGCGAGAGGGCGCGAGCGGCGGCGCTGCCTGCAGCCTGCAGCCTGCAGCCTCCGGCCGGCCGGCGAGCCAGTGCGCGTGCGCGGCGG
CGGCCTCCGCAGCGACCGGGGAGCGGACTGACCGGCGGGAGGGCTAGCGAGCCAGCGGTGTGAGGCGCGAGGCGAGGCCGAGCCGCGAGC
GACATGGGGGACCGGGAGCAGCTGCTGCAGCGGGCGCGGCTGGCCGAGCAGGCGGAGCGCTACGACGACATGGCCTCCGCTATGAAGGCG
GCTATGTTTTCCACCAATCGTGGGACTGTTGGAGGCTTCTTCCTGGCAGGCCGAAGTATGGTGTGGTGGCCGATTGGAGCCTCCCTCTTT
GCTAGTAACATTGGAAGTGGCCACTTTGTGGGGCTGGCCGGGACTGGGGCAGCTTCAGGCATCGCCATTGGAGGCTTTGAATGGAATGCC
CTGGTTTTGGTGGTTGTGCTGGGCTGGCTGTTTGTCCCCATCTATATTAAGGCTGGGGTGGTGACAATGCCAGAGTACCTGAGGAAGCGG
TTTGGAGGCCAGCGGATCCAGGTCTACCTTTCCCTTCTGTCCCTGCTGCTCTACATTTTCACCAAGATCTCGGCAGACATCTTCTCGGGG
GCCATATTCATCAATCTGGCCTTAGGCCTGAATCTGTATTTAGCCATCTTTCTCTTATTGGCAATCACTGCCCTTTACACAATTACAGGG
GGCCTGGCGGCGGTGATTTACACGGACACCTTGCAGACGGTGATCATGCTGGTGGGGTCTTTAATCCTGACTGGGTTTGCTTTTCACGAA
GTGGGAGGCTATGACGCCTTCATGGAAAAGTACATGAAAGCCATTCCAACCATAGTGTCTGATGGCAACACCACCTTTCAGGAAAAATGC
TACACTCCAAGGGCCGACTCCTTCCACATCTTCCGAGATCCCCTCACGGGAGACCTCCCATGGCCTGGGTTCATCTTTGGGATGTCCATC
CTTACCTTGTGGTACTGGTGCACAGATCAGGTCATTGTGCAGCGCTGCCTCTCAGCCAAGAATATGTCTCACGTGAAGGGTGGCTGCATC
CTGTGTGGGTATCTAAAGCTGATGCCCATGTTCATCATGGTGATGCCAGGAATGATCAGCCGCATTCTGTACACAGAAAAAATTGCCTGT
GTCGTCCCTTCAGAATGTGAGAAATATTGCGGTACCAAGGTTGGCTGTACCAACATCGCCTATCCAACCTTAGTGGTGGAGCTCATGCCC
AATGGACTGCGAGGCCTGATGCTATCAGTCATGCTGGCCTCCCTCATGAGCTCCCTGACCTCCATCTTCAACAGCGCCAGCACCCTCTTC
ACCATGGACATCTACGCCAAGGTCCGCAAGAGAGCATCTGAGAAAGAGCTCATGATTGCCGGAAGGTTGTTTATCCTGGTGCTGATTGGC
ATCAGCATCGCCTGGGTGCCCATTGTGCAGTCAGCACAAAGTGGGCAACTCTTCGATTACATCCAGTCCATCACCAGTTACTTGGGACCA
CCCATTGCGGCTGTCTTCCTGCTTGCTATTTTCTGGAAGAGAGTCAATGAGCCAGGAGCCTTTTGGGGACTGATCCTAGGACTTCTGATT
GGGATTTCACGTATGATTACTGAGTTTGCTTATGGAACCGGGAGCTGCATGGAGCCCAGCAACTGTCCCACGATTATCTGTGGGGTGCAC
TACTTGTACTTTGCCATTATCCTCTTCGCCATTTCTTTCATCACCATCGTGGTCATCTCCCTCCTCACCAAACCCATTCCGGATGTGCAT
CTCTACCGTCTGTGTTGGAGCCTGCGCAACAGCAAAGAGGAGCGTATTGACCTGGATGCGGAAGAGGAGAACATCCAAGAAGGCCCTAAG
GAGACCATTGAAATAGAAACACAAGTTCCTGAGAAGAAAAAAGGAATCTTCAGGAGAGCCTATGACCTATTTTGTGGGCTAGAGCAGCAC
GGTGCACCCAAGATGACTGAGGAAGAGGAGAAAGCCATGAAGATGAAGATGACGGACACCTCTGAGAAGCCTTTGTGGAGGACAGTGTTG
AACGTCAATGGCATCATCCTGGTGACCGTGGCTGTCTTTTGCCATGCATATTTTGCCTGAGTCCTACCTTTTGCTGTAGATTTACCATGG
CTGGACTCTTACTCACCTTCCTTTAGTCTCGTCCTGTGGTGTTGAAGGGAAATCAGCCAGTTGTAAATTTTGCCCAGGTGGATAAATGTG
TACATGTGTAATTATAGGCTAGCTGGAAGAAAACCATTAGTTTGCTGTTAATTTATGCATTTGAAGCCAGTGTGATACAGCCATCTGTAC
CTACTGGAGCTGCAGAAGGGAAGTCCACTCAGTCACATCCAGAAAAAGGCAGACTAAGAATCAGAAGCCATGTGATTGATGTCTGACGTG
AGTCTGTCTCAGGTAGATTCCGGGTGTCAGTGTGGTTTATAATCCTTGAATATTGTTTTAGAAACTTTGGTCTCCCTGGTTCCTGCCACT
TTTCCTGTCCGTCCTCCTCCCCATTTTTTTTTTAAAAGAAAGCTGTTTTCCCCTCATCATATCCCTCTTGAGTTTTGCCTGGACTTTCCC
TCTCAAGTGTGTCAATCAGGTAAACTGAGGAATGCATGGAAGCTGAGGATGGAGCTTGATGGGCTCCCTGTCCTGGGTGTTTGCTCTCTG
AAGTGGAGGCCTGAGGAAGGTAGTACTTCCACAAAAGGGAGGGACCCGGGCCCCAGCCTCAAGCTAGTGGGGGAGGCAGATAGCCTGAAT
CCAGGGGATTTTCTGGGCTTCTTAAAATGTCCATTGTGAGTTCCCCGTGTTTGGGATTCCACTCATTTTGGCATTCACAGTGCCTGGAAT
GTCTTAGATTTTCAGCAATGCGTGTTGAATAAATGAATGACATAGGCATTTATTTTTAAATCTTTGCTTGCTTTTTACATGAGCCTGGCC
CTTAGTTAACCTTTTCTTGTGGCTACACAAAGTATGCTCACTGGTTACTAATGACTTGGGATGCATTTGTCAAACTGATTATATTAGTTT
TCTAGGGATGCCATAACAAAGTAGCACAGACCAGATGGCTCAAGCAGCAGACATTTATTTTCTCACAGTTCTAGAGGCTAGAAGTTGGAG
GCCAAGATGTCAGCAGGGTTGGTTTCTTCTGAGGCCTCTCTCCTTGGTTGCAGATGGTCATATCTCACTCTGTCTTCCGTGGCCTTCCTT
TTGTCTGTGTCCTAAATCTACTCTTCTGATAAGGACATCAGTCATATTGGAATAGGACCCACCCTAATGTCTTCATTTTAATCACCTCTT
TAAAGCCCCTACCTCCAAATACAGTCACACTGTGAGAAACTGAGGGTTAGGAAGTCAGCAAGTGAGTCTTGAAGAGATACTAAACAAACC
CACAACACAGATAAAGTATGCATTTTGGAGATTTCCAAGCCAGAGTCTCCCGTGAAAAAGGTAAACGGAAGCAGTTATTGTGCAGCAAAA
GGAAAAAGAATTACAAACTGAACGTATGTAGGTGAGGCAAGGCAGGGTAGGGCAGGGCCTTTGGGTAGGCTGATCAGAGGGTTTTTCAAC
AATAAATCAATGGGAATGCATTTGTTGCTCCCAGGACCCTGGCACCTTGACTCTGGTACTATAGCATGTCAGCAAATACAAGCAAAGCCC
AACACTCTGATTTGCATTTATGCCAATCTAAACTATCCGGTGTTTAGTTTGATTTTTTGAGTGCAGGTTCATTCAAGGACCAGGTTCCCT
TGTGCTCAGGGTGAAGTAGAACCAGAAAACATCGTTATCCATTCCCAGAAGTTTTGGAAGAGCCTTGGTAGAAAAGCAGAAGCTGCTTTG
ACCGTGAAAATATTTGACTCCTATCAGTTTTTGGTCAGGAGAAGATATCCACCTAGACCAACCTGAGGAGAAGGCTCAGAGTACAGATAT
ACCCCGAGCAACGTGATCAATGTCCTTGAACCTTCATTTTTCATCTGAAAACAGAGACATAAATGCCTGGCTCACAGATTTAAATGTTAT
ACATTGACAGCATTTATCAGTATAACATTTATTTAAATAAGTAGGTGCTCAATAGGTGTTGGTCTTCTAACTTGTCTACATCCCATCCCC
ATTCCAGGGTCTTCAGAATTGAAGGAGAGATGTTGTATCACTGTTAGAAGGCTGCTTTGGGACATTCTGCAGCAGGGAGGAGGGACTGTC
AACCCCTACACCATGACCACCAAGTTCCTCACCTTGGCTGAGTCCCTAAAACTCTCTGAACCTCAGGTTCCTCCAAGCATAATGCAGACT
TCACAGAGCTGTTGTAAAGATTAGGTGAGGTCAATTGATACTGCTTAAAAGGCCCGGTCCGTAGAAAATGCCCAATAAACATTACTGCTT
TCCCCCTCACCCTACTGCCTGAAAAAATATTACACCTGTGAGACTGACTTTGAGAACCAGTGTGGGTGGGGAGTTGTGCATATAAACTAT
TTAATGAGTACCAAACACAAAAGTCAAGCTTGTAAAATATCAGGCCTTGCCCCAGAAAGACAAATACCACATGATCTCACTGATATGTAG
AATCTTAAAAAGTCAAACTCAGAAGCAGAGAGTAGAATGATGGTTATCAAGGGCTGGGGGAGGGAGGGACTGGGGAGATGTTGGTCAAAT
GATACAAAGGTTTAGTTAGGTGGAATAAGTTCAGAAAATCAATTGTACAATGTATCAATTATAGTTAATAGCAATATAACATATACTTGA
AAATTGCTGAGAGTAGTGTGAGTGTTCTACCACAAAAAAATATGTGCAGTAATAGATGTTAATTACCTTAATTTAGTCATTTCACAATAT

>100188_100188_1_YWHAH-SLC5A1_YWHAH_chr22_32340806_ENST00000248975_SLC5A1_chr22_32445930_ENST00000266088_length(amino acids)=648AA_BP=0
MGDREQLLQRARLAEQAERYDDMASAMKAAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNAL
VLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGG
LAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSIL
TLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPN
GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPP
IAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHL
YRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLN

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>100188_100188_2_YWHAH-SLC5A1_YWHAH_chr22_32340806_ENST00000397492_SLC5A1_chr22_32445930_ENST00000266088_length(transcript)=4975nt_BP=299nt
CGCGGCGCGAGCCACAGCGCGCGGGGCGAGCCAGCGAGAGGGCGCGAGCGGCGGCGCTGCCTGCAGCCTGCAGCCTGCAGCCTCCGGCCG
GCCGGCGAGCCAGTGCGCGTGCGCGGCGGCGGCCTCCGCAGCGACCGGGGAGCGGACTGACCGGCGGGAGGGCTAGCGAGCCAGCGGTGT
GAGGCGCGAGGCGAGGCCGAGCCGCGAGCGACATGGGGGACCGGGAGCAGCTGCTGCAGCGGGCGCGGCTGGCCGAGCAGGCGGAGCGCT
ACGACGACATGGCCTCCGCTATGAAGGCGGCTATGTTTTCCACCAATCGTGGGACTGTTGGAGGCTTCTTCCTGGCAGGCCGAAGTATGG
TGTGGTGGCCGATTGGAGCCTCCCTCTTTGCTAGTAACATTGGAAGTGGCCACTTTGTGGGGCTGGCCGGGACTGGGGCAGCTTCAGGCA
TCGCCATTGGAGGCTTTGAATGGAATGCCCTGGTTTTGGTGGTTGTGCTGGGCTGGCTGTTTGTCCCCATCTATATTAAGGCTGGGGTGG
TGACAATGCCAGAGTACCTGAGGAAGCGGTTTGGAGGCCAGCGGATCCAGGTCTACCTTTCCCTTCTGTCCCTGCTGCTCTACATTTTCA
CCAAGATCTCGGCAGACATCTTCTCGGGGGCCATATTCATCAATCTGGCCTTAGGCCTGAATCTGTATTTAGCCATCTTTCTCTTATTGG
CAATCACTGCCCTTTACACAATTACAGGGGGCCTGGCGGCGGTGATTTACACGGACACCTTGCAGACGGTGATCATGCTGGTGGGGTCTT
TAATCCTGACTGGGTTTGCTTTTCACGAAGTGGGAGGCTATGACGCCTTCATGGAAAAGTACATGAAAGCCATTCCAACCATAGTGTCTG
ATGGCAACACCACCTTTCAGGAAAAATGCTACACTCCAAGGGCCGACTCCTTCCACATCTTCCGAGATCCCCTCACGGGAGACCTCCCAT
GGCCTGGGTTCATCTTTGGGATGTCCATCCTTACCTTGTGGTACTGGTGCACAGATCAGGTCATTGTGCAGCGCTGCCTCTCAGCCAAGA
ATATGTCTCACGTGAAGGGTGGCTGCATCCTGTGTGGGTATCTAAAGCTGATGCCCATGTTCATCATGGTGATGCCAGGAATGATCAGCC
GCATTCTGTACACAGAAAAAATTGCCTGTGTCGTCCCTTCAGAATGTGAGAAATATTGCGGTACCAAGGTTGGCTGTACCAACATCGCCT
ATCCAACCTTAGTGGTGGAGCTCATGCCCAATGGACTGCGAGGCCTGATGCTATCAGTCATGCTGGCCTCCCTCATGAGCTCCCTGACCT
CCATCTTCAACAGCGCCAGCACCCTCTTCACCATGGACATCTACGCCAAGGTCCGCAAGAGAGCATCTGAGAAAGAGCTCATGATTGCCG
GAAGGTTGTTTATCCTGGTGCTGATTGGCATCAGCATCGCCTGGGTGCCCATTGTGCAGTCAGCACAAAGTGGGCAACTCTTCGATTACA
TCCAGTCCATCACCAGTTACTTGGGACCACCCATTGCGGCTGTCTTCCTGCTTGCTATTTTCTGGAAGAGAGTCAATGAGCCAGGAGCCT
TTTGGGGACTGATCCTAGGACTTCTGATTGGGATTTCACGTATGATTACTGAGTTTGCTTATGGAACCGGGAGCTGCATGGAGCCCAGCA
ACTGTCCCACGATTATCTGTGGGGTGCACTACTTGTACTTTGCCATTATCCTCTTCGCCATTTCTTTCATCACCATCGTGGTCATCTCCC
TCCTCACCAAACCCATTCCGGATGTGCATCTCTACCGTCTGTGTTGGAGCCTGCGCAACAGCAAAGAGGAGCGTATTGACCTGGATGCGG
AAGAGGAGAACATCCAAGAAGGCCCTAAGGAGACCATTGAAATAGAAACACAAGTTCCTGAGAAGAAAAAAGGAATCTTCAGGAGAGCCT
ATGACCTATTTTGTGGGCTAGAGCAGCACGGTGCACCCAAGATGACTGAGGAAGAGGAGAAAGCCATGAAGATGAAGATGACGGACACCT
CTGAGAAGCCTTTGTGGAGGACAGTGTTGAACGTCAATGGCATCATCCTGGTGACCGTGGCTGTCTTTTGCCATGCATATTTTGCCTGAG
TCCTACCTTTTGCTGTAGATTTACCATGGCTGGACTCTTACTCACCTTCCTTTAGTCTCGTCCTGTGGTGTTGAAGGGAAATCAGCCAGT
TGTAAATTTTGCCCAGGTGGATAAATGTGTACATGTGTAATTATAGGCTAGCTGGAAGAAAACCATTAGTTTGCTGTTAATTTATGCATT
TGAAGCCAGTGTGATACAGCCATCTGTACCTACTGGAGCTGCAGAAGGGAAGTCCACTCAGTCACATCCAGAAAAAGGCAGACTAAGAAT
CAGAAGCCATGTGATTGATGTCTGACGTGAGTCTGTCTCAGGTAGATTCCGGGTGTCAGTGTGGTTTATAATCCTTGAATATTGTTTTAG
AAACTTTGGTCTCCCTGGTTCCTGCCACTTTTCCTGTCCGTCCTCCTCCCCATTTTTTTTTTAAAAGAAAGCTGTTTTCCCCTCATCATA
TCCCTCTTGAGTTTTGCCTGGACTTTCCCTCTCAAGTGTGTCAATCAGGTAAACTGAGGAATGCATGGAAGCTGAGGATGGAGCTTGATG
GGCTCCCTGTCCTGGGTGTTTGCTCTCTGAAGTGGAGGCCTGAGGAAGGTAGTACTTCCACAAAAGGGAGGGACCCGGGCCCCAGCCTCA
AGCTAGTGGGGGAGGCAGATAGCCTGAATCCAGGGGATTTTCTGGGCTTCTTAAAATGTCCATTGTGAGTTCCCCGTGTTTGGGATTCCA
CTCATTTTGGCATTCACAGTGCCTGGAATGTCTTAGATTTTCAGCAATGCGTGTTGAATAAATGAATGACATAGGCATTTATTTTTAAAT
CTTTGCTTGCTTTTTACATGAGCCTGGCCCTTAGTTAACCTTTTCTTGTGGCTACACAAAGTATGCTCACTGGTTACTAATGACTTGGGA
TGCATTTGTCAAACTGATTATATTAGTTTTCTAGGGATGCCATAACAAAGTAGCACAGACCAGATGGCTCAAGCAGCAGACATTTATTTT
CTCACAGTTCTAGAGGCTAGAAGTTGGAGGCCAAGATGTCAGCAGGGTTGGTTTCTTCTGAGGCCTCTCTCCTTGGTTGCAGATGGTCAT
ATCTCACTCTGTCTTCCGTGGCCTTCCTTTTGTCTGTGTCCTAAATCTACTCTTCTGATAAGGACATCAGTCATATTGGAATAGGACCCA
CCCTAATGTCTTCATTTTAATCACCTCTTTAAAGCCCCTACCTCCAAATACAGTCACACTGTGAGAAACTGAGGGTTAGGAAGTCAGCAA
GTGAGTCTTGAAGAGATACTAAACAAACCCACAACACAGATAAAGTATGCATTTTGGAGATTTCCAAGCCAGAGTCTCCCGTGAAAAAGG
TAAACGGAAGCAGTTATTGTGCAGCAAAAGGAAAAAGAATTACAAACTGAACGTATGTAGGTGAGGCAAGGCAGGGTAGGGCAGGGCCTT
TGGGTAGGCTGATCAGAGGGTTTTTCAACAATAAATCAATGGGAATGCATTTGTTGCTCCCAGGACCCTGGCACCTTGACTCTGGTACTA
TAGCATGTCAGCAAATACAAGCAAAGCCCAACACTCTGATTTGCATTTATGCCAATCTAAACTATCCGGTGTTTAGTTTGATTTTTTGAG
TGCAGGTTCATTCAAGGACCAGGTTCCCTTGTGCTCAGGGTGAAGTAGAACCAGAAAACATCGTTATCCATTCCCAGAAGTTTTGGAAGA
GCCTTGGTAGAAAAGCAGAAGCTGCTTTGACCGTGAAAATATTTGACTCCTATCAGTTTTTGGTCAGGAGAAGATATCCACCTAGACCAA
CCTGAGGAGAAGGCTCAGAGTACAGATATACCCCGAGCAACGTGATCAATGTCCTTGAACCTTCATTTTTCATCTGAAAACAGAGACATA
AATGCCTGGCTCACAGATTTAAATGTTATACATTGACAGCATTTATCAGTATAACATTTATTTAAATAAGTAGGTGCTCAATAGGTGTTG
GTCTTCTAACTTGTCTACATCCCATCCCCATTCCAGGGTCTTCAGAATTGAAGGAGAGATGTTGTATCACTGTTAGAAGGCTGCTTTGGG
ACATTCTGCAGCAGGGAGGAGGGACTGTCAACCCCTACACCATGACCACCAAGTTCCTCACCTTGGCTGAGTCCCTAAAACTCTCTGAAC
CTCAGGTTCCTCCAAGCATAATGCAGACTTCACAGAGCTGTTGTAAAGATTAGGTGAGGTCAATTGATACTGCTTAAAAGGCCCGGTCCG
TAGAAAATGCCCAATAAACATTACTGCTTTCCCCCTCACCCTACTGCCTGAAAAAATATTACACCTGTGAGACTGACTTTGAGAACCAGT
GTGGGTGGGGAGTTGTGCATATAAACTATTTAATGAGTACCAAACACAAAAGTCAAGCTTGTAAAATATCAGGCCTTGCCCCAGAAAGAC
AAATACCACATGATCTCACTGATATGTAGAATCTTAAAAAGTCAAACTCAGAAGCAGAGAGTAGAATGATGGTTATCAAGGGCTGGGGGA
GGGAGGGACTGGGGAGATGTTGGTCAAATGATACAAAGGTTTAGTTAGGTGGAATAAGTTCAGAAAATCAATTGTACAATGTATCAATTA
TAGTTAATAGCAATATAACATATACTTGAAAATTGCTGAGAGTAGTGTGAGTGTTCTACCACAAAAAAATATGTGCAGTAATAGATGTTA
ATTACCTTAATTTAGTCATTTCACAATATGTACATATATAAAAATATGTTGTATGCCATGAGTATATATAATTATTATTTGTGAATTTAA

>100188_100188_2_YWHAH-SLC5A1_YWHAH_chr22_32340806_ENST00000397492_SLC5A1_chr22_32445930_ENST00000266088_length(amino acids)=648AA_BP=0
MGDREQLLQRARLAEQAERYDDMASAMKAAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNAL
VLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGG
LAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSIL
TLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPN
GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPP
IAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHL
YRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLN

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Fusion Gene PPI Analysis for YWHAH-SLC5A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for YWHAH-SLC5A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for YWHAH-SLC5A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource