FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:YWHAZ-GAL (FusionGDB2 ID:100214)

Fusion Gene Summary for YWHAZ-GAL

check button Fusion gene summary
Fusion gene informationFusion gene name: YWHAZ-GAL
Fusion gene ID: 100214
HgeneTgene
Gene symbol

YWHAZ

GAL

Gene ID

7534

51083

Gene nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetagalanin and GMAP prepropeptide
Synonyms14-3-3-zeta|HEL-S-3|HEL-S-93|HEL4|KCIP-1|POPCHAS|YWHADETL8|GAL-GMAP|GALN|GLNN|GMAP
Cytomap

8q22.3

11q13.2

Type of geneprotein-codingprotein-coding
Description14-3-3 protein zeta/delta14-3-3 delta14-3-3 protein/cytosolic phospholipase A214-3-3 zetaepididymis luminal protein 4epididymis secretory protein Li 3epididymis secretory protein Li 93phospholipase A2protein kinase C inhibitor protein-1tyrosine 3galanin peptidesgalanin prepropeptidegalanin-message-associated peptidegalanin-related peptidegalanin/GMAP prepropeptide
Modification date2020032920200329
UniProtAcc.

P07902

Ensembl transtripts involved in fusion geneENST00000395957, ENST00000395958, 
ENST00000521309, ENST00000353245, 
ENST00000395948, ENST00000395951, 
ENST00000395953, ENST00000395956, 
ENST00000419477, ENST00000457309, 
ENST00000492736, ENST00000522542, 
ENST00000522819, 
ENST00000265643, 
ENST00000538401, 
Fusion gene scores* DoF score22 X 20 X 10=44004 X 7 X 5=140
# samples 296
** MAII scorelog2(29/4400*10)=-3.92337871839709
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YWHAZ [Title/Abstract] AND GAL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointYWHAZ(101964157)-GAL(68452392), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYWHAZ

GO:0070372

regulation of ERK1 and ERK2 cascade

31024343

HgeneYWHAZ

GO:0090128

regulation of synapse maturation

16959763

TgeneGAL

GO:0010737

protein kinase A signaling

17982695

TgeneGAL

GO:0019933

cAMP-mediated signaling

17982695

TgeneGAL

GO:0045944

positive regulation of transcription by RNA polymerase II

24517231

TgeneGAL

GO:0051464

positive regulation of cortisol secretion

17982695

TgeneGAL

GO:0051795

positive regulation of timing of catagen

22329353

TgeneGAL

GO:1902608

positive regulation of large conductance calcium-activated potassium channel activity

24602615


check buttonFusion gene breakpoints across YWHAZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GAL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMZ-01AYWHAZchr8

101964157

-GALchr11

68452392

+
ChimerDB4BLCATCGA-XF-AAMZYWHAZchr8

101964156

-GALchr11

68452391

+
ChimerDB4BLCATCGA-XF-AAMZYWHAZchr8

101964156

-GALchr11

68453061

+
ChimerDB4BLCATCGA-XF-AAMZYWHAZchr8

101964157

-GALchr11

68452392

+
ChimerDB4BLCATCGA-XF-AAMZYWHAZchr8

101964157

-GALchr11

68453062

+


Top

Fusion Gene ORF analysis for YWHAZ-GAL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000395957ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
5UTR-intronENST00000395957ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
5UTR-intronENST00000395957ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
5UTR-intronENST00000395957ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
5UTR-intronENST00000395957ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
5UTR-intronENST00000395957ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
5UTR-intronENST00000395957ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
5UTR-intronENST00000395957ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
5UTR-intronENST00000395958ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
5UTR-intronENST00000395958ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
5UTR-intronENST00000395958ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
5UTR-intronENST00000395958ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
5UTR-intronENST00000395958ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
5UTR-intronENST00000395958ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
5UTR-intronENST00000395958ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
5UTR-intronENST00000395958ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
5UTR-intronENST00000521309ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
5UTR-intronENST00000521309ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
5UTR-intronENST00000521309ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
5UTR-intronENST00000521309ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
5UTR-intronENST00000521309ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
5UTR-intronENST00000521309ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
5UTR-intronENST00000521309ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
5UTR-intronENST00000521309ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000353245ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000353245ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000353245ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000353245ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000353245ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000353245ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000353245ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000353245ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395948ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395948ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395948ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395948ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395948ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395948ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395948ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395948ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395951ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395951ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395951ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395951ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395951ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395951ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395951ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395951ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395953ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395953ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395953ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395953ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395953ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395953ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395953ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395953ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395956ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395956ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395956ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395956ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000395956ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000395956ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000395956ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000395956ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000419477ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000419477ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000419477ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000419477ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000419477ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000419477ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000419477ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000419477ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000457309ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000457309ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000457309ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000457309ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000457309ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000457309ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000457309ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000457309ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000492736ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000492736ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000492736ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000492736ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000492736ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000492736ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000492736ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000492736ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000522542ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000522542ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000522542ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000522542ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000522542ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000522542ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000522542ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000522542ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000522819ENST00000265643YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000522819ENST00000265643YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000522819ENST00000265643YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000522819ENST00000265643YWHAZchr8

101964157

-GALchr11

68453062

+
intron-intronENST00000522819ENST00000538401YWHAZchr8

101964157

-GALchr11

68452392

+
intron-intronENST00000522819ENST00000538401YWHAZchr8

101964156

-GALchr11

68452391

+
intron-intronENST00000522819ENST00000538401YWHAZchr8

101964156

-GALchr11

68453061

+
intron-intronENST00000522819ENST00000538401YWHAZchr8

101964157

-GALchr11

68453062

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for YWHAZ-GAL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
YWHAZchr8101964156-GALchr1168452391+0.30943460.69056547
YWHAZchr8101964156-GALchr1168452391+0.30943460.69056547
YWHAZchr8101964156-GALchr1168453061+0.0235860140.976414
YWHAZchr8101964156-GALchr1168452391+0.30943460.69056547
YWHAZchr8101964156-GALchr1168452391+0.30943460.69056547
YWHAZchr8101964156-GALchr1168453061+0.0235860140.976414

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for YWHAZ-GAL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:101964157/:68452392)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GAL

P07902

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays an important role in galactose metabolism. {ECO:0000269|PubMed:22461411, ECO:0000269|PubMed:27005423}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for YWHAZ-GAL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for YWHAZ-GAL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for YWHAZ-GAL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for YWHAZ-GAL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource