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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:YWHAZ-MAL2 (FusionGDB2 ID:100223) |
Fusion Gene Summary for YWHAZ-MAL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YWHAZ-MAL2 | Fusion gene ID: 100223 | Hgene | Tgene | Gene symbol | YWHAZ | MAL2 | Gene ID | 7534 | 114569 |
| Gene name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | mal, T cell differentiation protein 2 (gene/pseudogene) | |
| Synonyms | 14-3-3-zeta|HEL-S-3|HEL-S-93|HEL4|KCIP-1|POPCHAS|YWHAD | - | |
| Cytomap | 8q22.3 | 8q24.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 14-3-3 protein zeta/delta14-3-3 delta14-3-3 protein/cytosolic phospholipase A214-3-3 zetaepididymis luminal protein 4epididymis secretory protein Li 3epididymis secretory protein Li 93phospholipase A2protein kinase C inhibitor protein-1tyrosine 3 | protein MAL2MAL proteolipid protein 2MAL2 proteolipid proteinmal, T-cell differentiation protein 2myelin and lymphocyte protein 2 | |
| Modification date | 20200329 | 20200326 | |
| UniProtAcc | . | Q969L2 | |
| Ensembl transtripts involved in fusion gene | ENST00000353245, ENST00000395948, ENST00000395951, ENST00000395953, ENST00000395956, ENST00000395957, ENST00000395958, ENST00000419477, ENST00000457309, ENST00000492736, ENST00000521309, ENST00000522542, ENST00000522819, | ENST00000521748, ENST00000276681, | |
| Fusion gene scores | * DoF score | 22 X 20 X 10=4400 | 2 X 2 X 2=8 |
| # samples | 29 | 2 | |
| ** MAII score | log2(29/4400*10)=-3.92337871839709 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: YWHAZ [Title/Abstract] AND MAL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | YWHAZ(101960823)-MAL2(120233826), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | YWHAZ-MAL2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. YWHAZ-MAL2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. YWHAZ-MAL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YWHAZ | GO:0070372 | regulation of ERK1 and ERK2 cascade | 31024343 |
| Hgene | YWHAZ | GO:0090128 | regulation of synapse maturation | 16959763 |
| Fusion gene breakpoints across YWHAZ (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MAL2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-LN-A8I1 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
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Fusion Gene ORF analysis for YWHAZ-MAL2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000353245 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000395948 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000395951 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000395953 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000395956 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000395957 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000395958 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000419477 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| 5CDS-3UTR | ENST00000457309 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| Frame-shift | ENST00000395948 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| Frame-shift | ENST00000395951 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| Frame-shift | ENST00000395953 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| Frame-shift | ENST00000395957 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| Frame-shift | ENST00000395958 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| Frame-shift | ENST00000419477 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| Frame-shift | ENST00000457309 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| In-frame | ENST00000353245 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| In-frame | ENST00000395956 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3CDS | ENST00000492736 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3CDS | ENST00000521309 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3CDS | ENST00000522542 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3CDS | ENST00000522819 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3UTR | ENST00000492736 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3UTR | ENST00000521309 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3UTR | ENST00000522542 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| intron-3UTR | ENST00000522819 | ENST00000521748 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000395956 | YWHAZ | chr8 | 101960823 | - | ENST00000276681 | MAL2 | chr8 | 120233826 | + | 3100 | 520 | 193 | 918 | 241 |
| ENST00000353245 | YWHAZ | chr8 | 101960823 | - | ENST00000276681 | MAL2 | chr8 | 120233826 | + | 2958 | 378 | 84 | 776 | 230 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000395956 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + | 0.000572376 | 0.9994276 |
| ENST00000353245 | ENST00000276681 | YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + | 0.000692914 | 0.99930704 |
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Fusion Genomic Features for YWHAZ-MAL2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + | 8.54E-07 | 0.99999917 |
| YWHAZ | chr8 | 101960823 | - | MAL2 | chr8 | 120233826 | + | 8.54E-07 | 0.99999917 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for YWHAZ-MAL2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:101960823/chr8:120233826) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MAL2 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 124_149 | 44 | 177.0 | Topological domain | Lumenal | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 171_176 | 44 | 177.0 | Topological domain | Cytoplasmic | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 56_66 | 44 | 177.0 | Topological domain | Lumenal | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 88_102 | 44 | 177.0 | Topological domain | Cytoplasmic | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 103_123 | 44 | 177.0 | Transmembrane | Helical | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 150_170 | 44 | 177.0 | Transmembrane | Helical | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 67_87 | 44 | 177.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 31_175 | 44 | 177.0 | Domain | MARVEL | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 1_34 | 44 | 177.0 | Topological domain | Cytoplasmic | |
| Tgene | MAL2 | chr8:101960823 | chr8:120233826 | ENST00000276681 | 1 | 5 | 35_55 | 44 | 177.0 | Transmembrane | Helical |
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Fusion Gene Sequence for YWHAZ-MAL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >100223_100223_1_YWHAZ-MAL2_YWHAZ_chr8_101960823_ENST00000353245_MAL2_chr8_120233826_ENST00000276681_length(transcript)=2958nt_BP=378nt GCCCACTCCCACCGCCAGCTGGAACCCTGGGGACTACGACGTCCCTCAAACCTTGCTTCTAGGAGATAAAAAGAACATCCAGTCATGGAT AAAAATGAGCTGGTTCAGAAGGCCAAACTGGCCGAGCAGGCTGAGCGATATGATGACATGGCAGCCTGCATGAAGTCTGTAACTGAGCAA GGAGCTGAATTATCCAATGAGGAGAGGAATCTTCTCTCAGTTGCTTATAAAAATGTTGTAGGAGCCCGTAGGTCATCTTGGAGGGTCGTC TCAAGTATTGAACAAAAGACGGAAGGTGCTGAGAAAAAACAGCAGATGGCTCGAGAATACAGAGAGAAAATTGAGACGGAGCTAAGAGAT ATCTGCAATGATGTACTGCTGTTCGGGGGTCTTGTCTGGATTTTGGTTGCCTCCTCCAATGTTCCTCTACCTCTACTACAAGGATGGGTC ATGTTTGTGTCCGTGACAGCGTTTTTCTTTTCGCTCCTCTTTCTGGGCATGTTCCTCTCTGGCATGGTGGCTCAAATTGATGCTAACTGG AACTTCCTGGATTTTGCCTACCATTTTACAGTATTTGTCTTCTATTTTGGAGCCTTTTTATTGGAAGCAGCAGCCACATCCCTGCATGAT TTGCATTGCAATACAACCATAACCGGGCAGCCACTCCTGAGTGATAACCAGTATAACATAAACGTAGCAGCCTCAATTTTTGCCTTTATG ACGACAGCTTGTTATGGTTGCAGTTTGGGTCTGGCTTTACGAAGATGGCGACCGTAACACTCCTTAGAAACTGGCAGTCGTATGTTAGTT TCACTTGTCTACTTTATATGTCTGATCAATTTGGATACCATTTTGTCCAGATGCAAAAACATTCCAAAAGTAATGTGTTTAGTAGAGAGA GACTCTAAGCTCAAGTTCTGGTTTATTTCATGGATGGAATGTTAATTTTATTATGATATTAAAGAAATGGCCTTTTATTTTACATCTCTC CCCTTTTTCCCTTTCCCCCTTTATTTTCCTCCTTTTCTTTCTGAAAGTTTCCTTTTATGTCCATAAAATACAAATATATTGTTCATAAAA AATTAGTATCCCTTTTGTTTGGTTGCTGAGTCACCTGAACCTTAATTTTAATTGGTAATTACAGCCCCTAAAAAAAACACATTTCAAATA GGCTTCCCACTAAACTCTATATTTTAGTGTAAACCAGGAATTGGCACACTTTTTTTAGAATGGGCCAGATGGTAAATATTTATGCTTCAC GGTCCATACAGTCTCTGTCACAACTATTCAGTTCTGCTAGTATAGCGTGAAAGCAGCTATACACAATACAGAAATGAATGAGTGTGGTTA TGTTCTAATAAAACTTATTTATAAAAACAAGGGGAGGCTGGGTTTAGCCTGTGGGCCATAGTTTGTCAACCACTGGTGTAAAACCTTAGT TATATATGATCTGCATTTTCTTGAACTGATCATTGAAAACTTATAAACCTAACAGAAAAGCCACATAATATTTAGTGTCATTATGCAATA ATCACATTGCCTTTGTGTTAATAGTCAAATACTTACCTTTGGAGAATACTTACCTTTGGAGGAATGTATAAAATTTCTCAGGCAGAGTCC TGGATATAGGAAAAAGTAATTTATGAAGTAAACTTCAGTTGCTTAATCAAACTAATGATAGTCTAACAACTGAGCAAGATCCTCATCTGA GAGTGCTTAAAATGGGATCCCCAGAGACCATTAACCAATACTGGAACTGGTATCTAGCTACTGATGTCTTACTTTGAGTTTATTTATGCT TCAGAATACAGTTGTTTGCCCTGTGCATGAATATACCCATATTTGTGTGTGGATATGTGAAGCTTTTCCAAATAGAGCTCTCAGAAGAAT TAAGTTTTTACTTCTAATTATTTTGCATTACTTTGAGTTAAATTTGAATAGAGTATTAAATATAAAGTTGTAGATTCTTATGTGTTTTTG TATTAGCCCAGACATCTGTAATGTTTTTGCACTGGTGACAGACAAAATCTGTTTTAAAATCATATCCAGCACAAAAACTATTTCTGGCTG AATAGCACAGAAAAGTATTTTAACCTACCTGTAGAGATCCTCGTCATGGAAAGGTGCCAAACTGTTTTGAATGGAAGGACAAGTAAGAGT GAGGCCACAGTTCCCACCACACGAGGGCTTTTGTATTGTTCTACTTTTTCAGCCCTTTACTTTCTGGCTGAAGCATCCCCTTGGAGTGCC ATGTATAAGTTGGGCTATTAGAGTTCATGGAACATAGAACAACCATGAATGAGTGGCATGATCCGTGCTTAATGATCAAGTGTTACTTAT CTAATAATCCTCTAGAAAGAACCCTGTTAGATCTTGGTTTGTGATAAAAATATAAAGACAGAAGACATGAGGAAAAACAAAAGGTTTGAG GAAATCAGGCATATGACTTTATACTTAACATCAGATCTTTTCTATAATATCCTACTACTTTGGTTTTCCTAGCTCCATACCACACACCTA AACCTGTATTATGAATTACATATTACAAAGTCATAAATGTGCCATATGGATATACAGTACATTCTAGTTGGAATCGTTTACTCTGCTAGA ATTTAGGTGTGAGATTTTTTGTTTCCCAGGTATAGCAGGCTTATGTTTGGTGGCATTAAATTGGTTTCTTTAAAATGCTTTGGTGGCACT TTTGTAAACAGATTGCTTCTAGATTGTTACAAACCAAGCCTAAGACACATCTGTGAATACTTAGATTTGTAGCTTAATCACATTCTAGAC TTGTGAGTTGAATGACAAAGCAGTTGAACAAAAATTATGGCATTTAAGAATTTAACATGTCTTAGCTGTAAAAATGAGAAAGTGTTGGTT >100223_100223_1_YWHAZ-MAL2_YWHAZ_chr8_101960823_ENST00000353245_MAL2_chr8_120233826_ENST00000276681_length(amino acids)=230AA_BP=98 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETEL RDICNDVLLFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSL -------------------------------------------------------------- >100223_100223_2_YWHAZ-MAL2_YWHAZ_chr8_101960823_ENST00000395956_MAL2_chr8_120233826_ENST00000276681_length(transcript)=3100nt_BP=520nt CCGCCCCCTCCCCTCTCCCTCGGCCGCCCCCTCCTTTCCCTCCCCCTCGCGCAGCCTCCGCGCTGGGCGCTGCGGCGGCGGGACCCGGCC CTCCCCCACCCCGGGAGGCGGTGGCGCGGCGGGGAGGGGCCGGGGGCCTCGGGGACCCAAGCGCGAGGGAAAGGCCTGGCCGAGAGCGGG CCGGAGCCCAGGCCTGGCGCGGCGGCGCCCGCCAGAACATCCAGTCATGGATAAAAATGAGCTGGTTCAGAAGGCCAAACTGGCCGAGCA GGCTGAGCGATATGATGACATGGCAGCCTGCATGAAGTCTGTAACTGAGCAAGGAGCTGAATTATCCAATGAGGAGAGGAATCTTCTCTC AGTTGCTTATAAAAATGTTGTAGGAGCCCGTAGGTCATCTTGGAGGGTCGTCTCAAGTATTGAACAAAAGACGGAAGGTGCTGAGAAAAA ACAGCAGATGGCTCGAGAATACAGAGAGAAAATTGAGACGGAGCTAAGAGATATCTGCAATGATGTACTGCTGTTCGGGGGTCTTGTCTG GATTTTGGTTGCCTCCTCCAATGTTCCTCTACCTCTACTACAAGGATGGGTCATGTTTGTGTCCGTGACAGCGTTTTTCTTTTCGCTCCT CTTTCTGGGCATGTTCCTCTCTGGCATGGTGGCTCAAATTGATGCTAACTGGAACTTCCTGGATTTTGCCTACCATTTTACAGTATTTGT CTTCTATTTTGGAGCCTTTTTATTGGAAGCAGCAGCCACATCCCTGCATGATTTGCATTGCAATACAACCATAACCGGGCAGCCACTCCT GAGTGATAACCAGTATAACATAAACGTAGCAGCCTCAATTTTTGCCTTTATGACGACAGCTTGTTATGGTTGCAGTTTGGGTCTGGCTTT ACGAAGATGGCGACCGTAACACTCCTTAGAAACTGGCAGTCGTATGTTAGTTTCACTTGTCTACTTTATATGTCTGATCAATTTGGATAC CATTTTGTCCAGATGCAAAAACATTCCAAAAGTAATGTGTTTAGTAGAGAGAGACTCTAAGCTCAAGTTCTGGTTTATTTCATGGATGGA ATGTTAATTTTATTATGATATTAAAGAAATGGCCTTTTATTTTACATCTCTCCCCTTTTTCCCTTTCCCCCTTTATTTTCCTCCTTTTCT TTCTGAAAGTTTCCTTTTATGTCCATAAAATACAAATATATTGTTCATAAAAAATTAGTATCCCTTTTGTTTGGTTGCTGAGTCACCTGA ACCTTAATTTTAATTGGTAATTACAGCCCCTAAAAAAAACACATTTCAAATAGGCTTCCCACTAAACTCTATATTTTAGTGTAAACCAGG AATTGGCACACTTTTTTTAGAATGGGCCAGATGGTAAATATTTATGCTTCACGGTCCATACAGTCTCTGTCACAACTATTCAGTTCTGCT AGTATAGCGTGAAAGCAGCTATACACAATACAGAAATGAATGAGTGTGGTTATGTTCTAATAAAACTTATTTATAAAAACAAGGGGAGGC TGGGTTTAGCCTGTGGGCCATAGTTTGTCAACCACTGGTGTAAAACCTTAGTTATATATGATCTGCATTTTCTTGAACTGATCATTGAAA ACTTATAAACCTAACAGAAAAGCCACATAATATTTAGTGTCATTATGCAATAATCACATTGCCTTTGTGTTAATAGTCAAATACTTACCT TTGGAGAATACTTACCTTTGGAGGAATGTATAAAATTTCTCAGGCAGAGTCCTGGATATAGGAAAAAGTAATTTATGAAGTAAACTTCAG TTGCTTAATCAAACTAATGATAGTCTAACAACTGAGCAAGATCCTCATCTGAGAGTGCTTAAAATGGGATCCCCAGAGACCATTAACCAA TACTGGAACTGGTATCTAGCTACTGATGTCTTACTTTGAGTTTATTTATGCTTCAGAATACAGTTGTTTGCCCTGTGCATGAATATACCC ATATTTGTGTGTGGATATGTGAAGCTTTTCCAAATAGAGCTCTCAGAAGAATTAAGTTTTTACTTCTAATTATTTTGCATTACTTTGAGT TAAATTTGAATAGAGTATTAAATATAAAGTTGTAGATTCTTATGTGTTTTTGTATTAGCCCAGACATCTGTAATGTTTTTGCACTGGTGA CAGACAAAATCTGTTTTAAAATCATATCCAGCACAAAAACTATTTCTGGCTGAATAGCACAGAAAAGTATTTTAACCTACCTGTAGAGAT CCTCGTCATGGAAAGGTGCCAAACTGTTTTGAATGGAAGGACAAGTAAGAGTGAGGCCACAGTTCCCACCACACGAGGGCTTTTGTATTG TTCTACTTTTTCAGCCCTTTACTTTCTGGCTGAAGCATCCCCTTGGAGTGCCATGTATAAGTTGGGCTATTAGAGTTCATGGAACATAGA ACAACCATGAATGAGTGGCATGATCCGTGCTTAATGATCAAGTGTTACTTATCTAATAATCCTCTAGAAAGAACCCTGTTAGATCTTGGT TTGTGATAAAAATATAAAGACAGAAGACATGAGGAAAAACAAAAGGTTTGAGGAAATCAGGCATATGACTTTATACTTAACATCAGATCT TTTCTATAATATCCTACTACTTTGGTTTTCCTAGCTCCATACCACACACCTAAACCTGTATTATGAATTACATATTACAAAGTCATAAAT GTGCCATATGGATATACAGTACATTCTAGTTGGAATCGTTTACTCTGCTAGAATTTAGGTGTGAGATTTTTTGTTTCCCAGGTATAGCAG GCTTATGTTTGGTGGCATTAAATTGGTTTCTTTAAAATGCTTTGGTGGCACTTTTGTAAACAGATTGCTTCTAGATTGTTACAAACCAAG CCTAAGACACATCTGTGAATACTTAGATTTGTAGCTTAATCACATTCTAGACTTGTGAGTTGAATGACAAAGCAGTTGAACAAAAATTAT GGCATTTAAGAATTTAACATGTCTTAGCTGTAAAAATGAGAAAGTGTTGGTTGGTTTTAAAATCTGGTAACTCCATGATGAAAAGAAATT >100223_100223_2_YWHAZ-MAL2_YWHAZ_chr8_101960823_ENST00000395956_MAL2_chr8_120233826_ENST00000276681_length(amino acids)=241AA_BP=109 MARRRPPEHPVMDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMA REYREKIETELRDICNDVLLFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for YWHAZ-MAL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for YWHAZ-MAL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for YWHAZ-MAL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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