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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BOP1-NECAB1 (FusionGDB2 ID:10033)

Fusion Gene Summary for BOP1-NECAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: BOP1-NECAB1
Fusion gene ID: 10033
HgeneTgene
Gene symbol

BOP1

NECAB1

Gene ID

23246

64168

Gene nameBOP1 ribosomal biogenesis factorN-terminal EF-hand calcium binding protein 1
Synonyms-EFCBP1|STIP-1
Cytomap

8q24.3

8q21.3

Type of geneprotein-codingprotein-coding
Descriptionribosome biogenesis protein BOP1block of proliferation 1N-terminal EF-hand calcium-binding protein 1EF-hand calcium-binding protein 1neuronal calcium binding proteinneuronal calcium-binding protein 1synaptotagmin interacting protein 1
Modification date2020031320200313
UniProtAcc

Q14137

Q8N987

Ensembl transtripts involved in fusion geneENST00000307404, ENST00000529231, 
ENST00000525016, 		ENST00000521954, 
ENST00000521366, ENST00000522820, 
ENST00000417640, 
Fusion gene scores* DoF score9 X 7 X 8=5046 X 3 X 4=72
# samples 126
** MAII scorelog2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BOP1 [Title/Abstract] AND NECAB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBOP1(145500212)-NECAB1(91813919), # samples:2
Anticipated loss of major functional domain due to fusion event.BOP1-NECAB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BOP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NECAB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YX-01ABOP1chr8

145500212

-NECAB1chr8

91813919

+


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Fusion Gene ORF analysis for BOP1-NECAB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000307404ENST00000521954BOP1chr8

145500212

-NECAB1chr8

91813919

+
5CDS-3UTRENST00000529231ENST00000521954BOP1chr8

145500212

-NECAB1chr8

91813919

+
5CDS-intronENST00000307404ENST00000521366BOP1chr8

145500212

-NECAB1chr8

91813919

+
5CDS-intronENST00000307404ENST00000522820BOP1chr8

145500212

-NECAB1chr8

91813919

+
5CDS-intronENST00000529231ENST00000521366BOP1chr8

145500212

-NECAB1chr8

91813919

+
5CDS-intronENST00000529231ENST00000522820BOP1chr8

145500212

-NECAB1chr8

91813919

+
Frame-shiftENST00000529231ENST00000417640BOP1chr8

145500212

-NECAB1chr8

91813919

+
In-frameENST00000307404ENST00000417640BOP1chr8

145500212

-NECAB1chr8

91813919

+
intron-3CDSENST00000525016ENST00000417640BOP1chr8

145500212

-NECAB1chr8

91813919

+
intron-3UTRENST00000525016ENST00000521954BOP1chr8

145500212

-NECAB1chr8

91813919

+
intron-intronENST00000525016ENST00000521366BOP1chr8

145500212

-NECAB1chr8

91813919

+
intron-intronENST00000525016ENST00000522820BOP1chr8

145500212

-NECAB1chr8

91813919

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000307404BOP1chr8145500212-ENST00000417640NECAB1chr891813919+5273420301376448

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307404ENST00000417640BOP1chr8145500212-NECAB1chr891813919+0.000194480.9998055

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Fusion Genomic Features for BOP1-NECAB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BOP1chr8145500211-NECAB1chr891813918+0.0121308840.9878691
BOP1chr8145500211-NECAB1chr891813918+0.0121308840.9878691

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BOP1-NECAB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145500212/chr8:91813919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BOP1

Q14137

NECAB1

Q8N987

FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNECAB1chr8:145500212chr8:91813919ENST0000041764001339_5033352.0Calcium binding1
TgeneNECAB1chr8:145500212chr8:91813919ENST000005213660439_500101.0Calcium binding1
TgeneNECAB1chr8:145500212chr8:91813919ENST000005228200539_500101.0Calcium binding1
TgeneNECAB1chr8:145500212chr8:91813919ENST00000417640013135_16333352.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:145500212chr8:91813919ENST00000417640013209_27533352.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:145500212chr8:91813919ENST0000052136604135_1630101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:145500212chr8:91813919ENST0000052136604209_2750101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:145500212chr8:91813919ENST0000052282005135_1630101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:145500212chr8:91813919ENST0000052282005209_2750101.0Coiled coilOntology_term=ECO:0000255
TgeneNECAB1chr8:145500212chr8:91813919ENST00000417640013252_34033352.0DomainNote=ABM
TgeneNECAB1chr8:145500212chr8:91813919ENST0000041764001360_9533352.0DomainEF-hand 2
TgeneNECAB1chr8:145500212chr8:91813919ENST0000052136604252_3400101.0DomainNote=ABM
TgeneNECAB1chr8:145500212chr8:91813919ENST000005213660426_610101.0DomainEF-hand 1
TgeneNECAB1chr8:145500212chr8:91813919ENST000005213660460_950101.0DomainEF-hand 2
TgeneNECAB1chr8:145500212chr8:91813919ENST0000052282005252_3400101.0DomainNote=ABM
TgeneNECAB1chr8:145500212chr8:91813919ENST000005228200526_610101.0DomainEF-hand 1
TgeneNECAB1chr8:145500212chr8:91813919ENST000005228200560_950101.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316265_427130747.0RegionSufficient for nucleolar localization
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316411_450130747.0RepeatNote=WD 1
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316452_492130747.0RepeatNote=WD 2
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316532_576130747.0RepeatNote=WD 3
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316577_615130747.0RepeatNote=WD 4
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316618_657130747.0RepeatNote=WD 5
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316661_700130747.0RepeatNote=WD 6
HgeneBOP1chr8:145500212chr8:91813919ENST00000307404-316716_746130747.0RepeatNote=WD 7
TgeneNECAB1chr8:145500212chr8:91813919ENST0000041764001326_6133352.0DomainEF-hand 1


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Fusion Gene Sequence for BOP1-NECAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10033_10033_1_BOP1-NECAB1_BOP1_chr8_145500212_ENST00000307404_NECAB1_chr8_91813919_ENST00000417640_length(transcript)=5273nt_BP=420nt
GTGCGGGTGGCGGCCGGCGCGCGGTGGGGCATGGCGGGTTCGCGGGGTGCGGGGCGCACGGCGGCGCCGAGCGTGCGGCCGGAGAAGCGG
CGGTCTGAGCCCGAACTGGAGCCTGAGCCCGAGCCGGAGCCCCCCCTCCTCTGCACCTCTCCTCTCAGCCACAGCACCGGCAGCGATTCT
GGCGTCTCCGACAGCGAGGAGAGTGTGTTCTCAGGCCTGGAAGATTCCGGCAGTGACAGCAGTGAGGATGATGACGAAGGCGACGAGGAG
GGAGAGGACGGAGCCCTTGATGACGAGGGCCACAGTGGGATTAAAAAGACCACTGAGGAGCAGGTGCAGGCCAGCACTCCTTGCCCGAGG
ACAGAGATGGCGAGCGCCCGGATTGGGGATGAGTATGCGGAGGACAGCTCTGATGAGGAGATACTGAGGAGAGCAGACAAAAATGATGAT
GGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTTTTCCATACCATTGAT
ACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAATGTACTAGCAGCACTT
GAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAACAATTCGTAACTAGA
TTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAGGAGCAAACCCGTCAA
GAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAGAGACACAACAGCTTC
TCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATAAATAGACTCCAGAAA
TTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAATCTCACATCATGCTT
GTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGTGCTTCCTCCCAAAGT
GGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAGTGTATGGAATAGC
CACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCTACAATGCTAGTTCCT
GCTTCGTGGTGGATCCTGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTTATCTAAAACGTCA
ATTAGAAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAACTTATTCTATAACT
TTATCAATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCTACATTGTAACTCA
CCTAAAACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATGAATCTGTTATGATAA
AGAAAAAATAAAGTGGAAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGTTAAATCAGCGTTT
TGTGATTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCCCTATGACTACTATCT
TTGCATTAGTTAAAAAGTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTATCAGGTTATAGACTGG
TTTTTCAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAGCATCATAATTCTTTG
TTATGTAAGTTAAATATATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTGGTATGCGATACAG
ACAGCTAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTTTAACCCAAATGAATA
ACTAAGAAATATAAAACAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCTGTTTTCGAATTTC
AACACTAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAAGCTCAGAAATTAAAT
ATTTTTAATAATAAAAATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCATGTTATTTTCTAGT
ATAAATTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAAACTCAGGAAAAAAGG
AAGATTGAACTAATAAAATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACAGCAACTTTTACCA
ATACCTTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATAAGTAGTAAATTTTGA
TATATTGTACATACACACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGTCAACTCTAAGGAT
GACAGACACTGTGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGATGCACAATGATTATT
CAAACAAGCTATATATATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAAGATCAAAAGACTT
TAAAACCTAAATGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATTATAGCCAATCAAAAC
ATTGCTTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAGTAGCATGGTAGTA
TTACTTGTTAAAAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAGCTCTATCATATTCTG
AAACAAGAATTAGAATGACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCCCAGCTCTTATACAAA
TTATACATGTATTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACACATATATACTGGAACC
TATAGTAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACTGGGACCTAAGTAT
AAATATCTCATCCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCTAAAGAACAAAGTAGT
AAAATAAAAAAAAATTTAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACATGGAATACAAGCTTG
AATCTGGGAAACAAGCTCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAACTTTTTGCCAATAGAC
CTAGGGATCTAAGAAATAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAAACCCTTTTTTTTTTT
TTTTTTAAACAGTAACATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTTAAACCCAAAAATTGT
TCATCCATATATAAGAAATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGGAAATAAAAATATCAG
TTTTACTTTGAAATTGCTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAACTTCAGTTTCATTCAC
TACCATTGTTTCCAAATTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAGACCAATCATATATCT
GAAAAGAAATACCCATTAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAAGCCTCTGGAGAGACT
GTAATGATCCATTCATGAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGCAATTATGTACCATAT
ATACACTGTAGCAAATATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAAAAACAAAAAATTGCA
AGTAGTATGCAAATTATAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCAATTTATGCAGGAAAC
CTCCTGCAAAGCTGAAACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAAATAGCCAACCATCAA
AATTAAGAATAAATTGAATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAAACTTAAATTCATCTG
TTCTTAAAATGCTACTTAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGAATACAGTTTTTACTA
ATTAGTTTATCAAACCAAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTATTAAAGTAACTAGAAC
TGTCAAATAACAAAACGGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAACCTGTTCTTCTGTTT
CTGTGGCACCTAGGTTTAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTTTTAAAAAGTGTATGT

>10033_10033_1_BOP1-NECAB1_BOP1_chr8_145500212_ENST00000307404_NECAB1_chr8_91813919_ENST00000417640_length(amino acids)=448AA_BP=130
MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVFSGLEDSGSDSSEDDDEGDEEGEDGALDDEG
HSGIKKTTEEQVQASTPCPRTEMASARIGDEYAEDSSDEEILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTE
ELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEV
LSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEE

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Fusion Gene PPI Analysis for BOP1-NECAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BOP1-NECAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BOP1-NECAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource