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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZBTB48-ESPN (FusionGDB2 ID:100448)

Fusion Gene Summary for ZBTB48-ESPN

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB48-ESPN
Fusion gene ID: 100448
HgeneTgene
Gene symbol

ZBTB48

ESPN

Gene ID

3104

83715

Gene namezinc finger and BTB domain containing 48espin
SynonymsHKR3|TZAP|ZNF855|pp9964DFNB36|LP2654|USH1M
Cytomap

1p36.31

1p36.31

Type of geneprotein-codingprotein-coding
Descriptiontelomere zinc finger-associated proteinGLI-Kruppel family member HKR3krueppel-related zinc finger protein 3telomeric zinc finger-associated proteinzinc finger and BTB domain-containing protein 48zinc finger protein 855espinautosomal recessive deafness type 36 proteinectoplasmic specialization protein
Modification date2020031320200313
UniProtAcc.

Q6ZVH7

Ensembl transtripts involved in fusion geneENST00000377674, ENST00000416731, 
ENST00000461727, ENST00000475228, 
ENST00000377828, 
Fusion gene scores* DoF score4 X 5 X 3=605 X 4 X 3=60
# samples 45
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZBTB48 [Title/Abstract] AND ESPN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZBTB48(6647351)-ESPN(6488286), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZBTB48 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ESPN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0786-01BZBTB48chr1

6647351

-ESPNchr1

6488286

+


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Fusion Gene ORF analysis for ZBTB48-ESPN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377674ENST00000416731ZBTB48chr1

6647351

-ESPNchr1

6488286

+
5CDS-intronENST00000377674ENST00000461727ZBTB48chr1

6647351

-ESPNchr1

6488286

+
5CDS-intronENST00000377674ENST00000475228ZBTB48chr1

6647351

-ESPNchr1

6488286

+
In-frameENST00000377674ENST00000377828ZBTB48chr1

6647351

-ESPNchr1

6488286

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377674ZBTB48chr16647351-ENST00000377828ESPNchr16488286+445113823236521206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377674ENST00000377828ZBTB48chr16647351-ESPNchr16488286+0.0104286770.98957133

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Fusion Genomic Features for ZBTB48-ESPN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZBTB48-ESPN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6647351/chr1:6488286)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ESPN

Q6ZVH7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-61126_89408689.0DomainBTB
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611291_313408689.0Zinc fingerC2H2-type 1
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611319_341408689.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611350_372408689.0Zinc fingerC2H2-type 3
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611378_401408689.0Zinc fingerC2H2-type 4
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013756_83098855.0Coiled coilOntology_term=ECO:0000255
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107756_8300289.0Coiled coilOntology_term=ECO:0000255
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708756_8300289.0Coiled coilOntology_term=ECO:0000255
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013428_73098855.0Compositional biasNote=Pro-rich
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013768_82598855.0Compositional biasNote=Glu-rich
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107428_7300289.0Compositional biasNote=Pro-rich
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107768_8250289.0Compositional biasNote=Glu-rich
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708428_7300289.0Compositional biasNote=Pro-rich
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708768_8250289.0Compositional biasNote=Glu-rich
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013651_66898855.0DomainWH2
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107651_6680289.0DomainWH2
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708651_6680289.0DomainWH2
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013103_13398855.0RepeatNote=ANK 4
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013137_16798855.0RepeatNote=ANK 5
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013171_20198855.0RepeatNote=ANK 6
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013205_23598855.0RepeatNote=ANK 7
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013239_26898855.0RepeatNote=ANK 8
TgeneESPNchr1:6647351chr1:6488286ENST00000377828013271_30098855.0RepeatNote=ANK 9
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107103_1330289.0RepeatNote=ANK 4
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107137_1670289.0RepeatNote=ANK 5
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107171_2010289.0RepeatNote=ANK 6
TgeneESPNchr1:6647351chr1:6488286ENST00000416731071_310289.0RepeatNote=ANK 1
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107205_2350289.0RepeatNote=ANK 7
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107239_2680289.0RepeatNote=ANK 8
TgeneESPNchr1:6647351chr1:6488286ENST0000041673107271_3000289.0RepeatNote=ANK 9
TgeneESPNchr1:6647351chr1:6488286ENST000004167310735_640289.0RepeatNote=ANK 2
TgeneESPNchr1:6647351chr1:6488286ENST000004167310769_990289.0RepeatNote=ANK 3
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708103_1330289.0RepeatNote=ANK 4
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708137_1670289.0RepeatNote=ANK 5
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708171_2010289.0RepeatNote=ANK 6
TgeneESPNchr1:6647351chr1:6488286ENST00000461727081_310289.0RepeatNote=ANK 1
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708205_2350289.0RepeatNote=ANK 7
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708239_2680289.0RepeatNote=ANK 8
TgeneESPNchr1:6647351chr1:6488286ENST0000046172708271_3000289.0RepeatNote=ANK 9
TgeneESPNchr1:6647351chr1:6488286ENST000004617270835_640289.0RepeatNote=ANK 2
TgeneESPNchr1:6647351chr1:6488286ENST000004617270869_990289.0RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611407_430408689.0Zinc fingerC2H2-type 5
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611436_459408689.0Zinc fingerC2H2-type 6
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611465_487408689.0Zinc fingerC2H2-type 7
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611493_515408689.0Zinc fingerC2H2-type 8
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611521_544408689.0Zinc fingerC2H2-type 9
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611550_572408689.0Zinc fingerC2H2-type 10
HgeneZBTB48chr1:6647351chr1:6488286ENST00000377674-611578_600408689.0Zinc fingerC2H2-type 11
TgeneESPNchr1:6647351chr1:6488286ENST000003778280131_3198855.0RepeatNote=ANK 1
TgeneESPNchr1:6647351chr1:6488286ENST0000037782801335_6498855.0RepeatNote=ANK 2
TgeneESPNchr1:6647351chr1:6488286ENST0000037782801369_9998855.0RepeatNote=ANK 3


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Fusion Gene Sequence for ZBTB48-ESPN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100448_100448_1_ZBTB48-ESPN_ZBTB48_chr1_6647351_ENST00000377674_ESPN_chr1_6488286_ENST00000377828_length(transcript)=4451nt_BP=1382nt
GGGTACGCATAGCCGGGCACTAGGTTCGTGGGCTGTGGAGGCGACGGAGCAGGGGGCCAGTGGGGCCAGCTCAGGGAGGACCTGCCTGGG
AGCTTTCTCTTGCATACCCTCGCTTAGGCTGGCCGGGGTGTCACTTCTGCCTCCCTGCCCTCCAGACCATGGACGGCTCCTTCGTCCAGC
ACAGTGTGAGGGTTCTGCAGGAGCTCAACAAGCAGCGGGAGAAGGGCCAGTACTGCGACGCCACTCTGGACGTGGGGGGCCTGGTGTTTA
AGGCACACTGGAGTGTCCTTGCCTGCTGCAGTCACTTTTTCCAGAGCCTCTACGGGGATGGCTCAGGGGGCAGTGTCGTCCTCCCTGCTG
GCTTCGCTGAGATCTTTGGCCTCTTGTTGGACTTTTTCTACACTGGTCACCTCGCTCTCACCTCAGGGAACCGGGATCAGGTGCTCCTGG
CAGCCAGGGAGTTGCGAGTGCCAGAGGCCGTAGAGCTGTGCCAGAGCTTCAAGCCCAAAACTTCAGTGGGACAGGCAGCAGGTGGCCAGA
GTGGGCTGGGGCCCCCTGCCTCCCAGAATGTGAACAGCCACGTCAAGGAGCCGGCAGGCTTGGAAGAAGAGGAAGTTTCGAGGACTCTGG
GTCTAGTCCCCAGGGATCAGGAGCCCAGAGGCAGTCATAGTCCTCAGAGGCCCCAGCTCCATTCCCCAGCTCAGAGTGAGGGCCCCTCCT
CCCTCTGTGGGAAACTGAAGCAGGCCTTGAAGCCTTGTCCCCTTGAGGACAAGAAACCCGAGGACTGCAAAGTGCCCCCAAGGCCCTTAG
AGGCTGAAGGTGCCCAGCTGCAGGGCGGCAGTAATGAGTGGGAAGTGGTGGTTCAAGTGGAGGATGATGGGGATGGCGATTACATGTCTG
AGCCTGAGGCTGTGCTGACCAGGAGGAAGTCAAATGTAATCCGAAAGCCCTGTGCAGCTGAGCCAGCCCTGAGCGCGGGCTCCCTAGCAG
CTGAGCCTGCTGAGAACAGAAAAGGTACAGCGGTGCCGGTCGAATGCCCCACATGTCATAAAAAGTTCCTCAGCAAATATTATCTAAAAG
TCCACAACAGGAAACATACTGGGGAGAAACCCTTTGAGTGTCCCAAATGTGGGAAGTGTTACTTTCGGAAGGAGAACCTCCTGGAGCATG
AAGCCCGGAATTGCATGAACCGCTCGGAACAGGTCTTCACGTGCTCTGTGTGCCAGGAGACATTCCGCCGAAGGATGGAGCTGCGGGTGC
ACATGGTGTCTCACACAGGGGAGATGCCCTACAAGTGTTCCTCCTGCTCCCAGCAGTTCATGCAGAAGAAGGACTTGCAGAGCCACATGA
TCAAACTTCATGGAGCCCCCAAGCCCCATGCAGACAAAGACAATTCTGGTGCCACAGTCTTGCATCTGGCTGCCCGCTTCGGCCACCCCG
AGGTGGTGAACTGGCTCTTGCATCATGGCGGTGGGGACCCCACCGCGGCCACAGACATGGGCGCCCTGCCTATCCACTACGCTGCCGCCA
AAGGAGACTTCCCCTCCCTGAGGCTTCTCGTCGAGCACTACCCTGAGGGAGTGAATGCCCAAACCAAGAACGGTGCCACGCCCCTGTACC
TGGCGTGCCAGGAGGGCCACCTGGAGGTGACCCAGTACCTGGTGCAGGAATGCGGCGCAGACCCGCACGCGCGCGCCCACGACGGCATGA
CCCCGCTGCACGCCGCGGCGCAGATGGGCCACAGCCCAGTCATCGTGTGGTTGGTGAGCTGCACCGACGTGAGCCTGTCCGAGCAGGACA
AAGACGGCGCCACCGCCATGCACTTCGCGGCGAGCCGCGGCCACACCAAGGTGCTCAGCTGGCTGCTGCTGCACGGCGGGGAGATCTCGG
CTGACCTGTGGGGCGGGACCCCGCTGCACGACGCCGCCGAGAACGGGGAGCTAGAGTGCTGCCAGATCCTGGTAGTGAACGGCGCGGAGC
TGGACGTCCGCGACCGCGACGGGTACACGGCCGCCGACCTGTCGGACTTCAACGGCCACAGCCACTGCACCCGCTACCTGCGCACGGTGG
AGAACCTGAGCGTGGAGCACCGCGTGCTTTCCCGGGATCCATCCGCAGAGCTGGAGGCTAAGCAGCCGGATTCAGGCATGTCCTCACCCA
ATACCACGGTGTCGGTCCAGCCGCTGAACTTTGACCTCAGCTCGCCTACCAGCACCCTCTCCAACTACGACTCCTGCTCCTCCAGCCACT
CCAGCATCAAGGGCCAGCACCCTCCATGTGGGCTTTCCAGCGCTAGAGCTGCAGACATACAGAGCTACATGGACATGCTGAACCCGGAGC
TGGGCCTGCCTCGGGGCACGATTGGGAAGCCCACACCCCCACCACCCCCACCCAGCTTCCCCCCGCCACCCCCGCCCCCAGGCACCCAAC
TGCCCCCACCCCCACCTGGCTACCCAGCTCCCAAGCCTCCTGTAGGACCACAGGCAGCTGACATCTACATGCAGACCAAGAACAAACTCC
GCCACGTGGAGACAGAGGCCCTCAAGAAGGAGCTGAGCTCCTGTGACGGCCACGACGGGCTGCGGAGGCAGGACTCCAGCCGCAAGCCCC
GCGCCTTCAGCAAGCAGCCCAGCACGGGGGACTACTACCGGCAGCTGGGCCGCTGCCCCGGCGAGACGCTGGCCGCACGCCCGGGCATGG
CGCACAGCGAGGAGGTGCGTGCCCGCCAGCCCGCGCGCGCCGGCTGCCCGCGCCTCGGCCCTGCCGCCCGCGGCTCACTCGAAGGCCCCT
CCGCTCCCCCGCAGGCGGCGCTGCTTCCTGGGAACCATGTTCCTAACGGCTGCGCCGCGGACCCCAAGGCGTCCAGGGAGCTGCCACCGC
CGCCCCCACCGCCGCCGCCGCCCCTGCCGGAGGCCGCGAGTTCGCCACCGCCGGCCCCGCCTCTGCCCCTCGAGAGCGCTGGCCCTGGCT
GCGGGCAGCGCCGCTCCTCCTCGTCCACCGGCAGCACCAAGTCTTTCAACATGATGTCCCCGACGGGCGACAACTCGGAGCTACTGGCTG
AGATTAAGGCAGGCAAGAGCCTGAAGCCGACGCCCCAGAGCAAGGGGCTGACCACAGTGTTCTCAGGCATCGGGCAGCCGGCCTTCCAGC
CCGATTCGCCGCTGCCTTCTGTGTCACCTGCACTGTCACCAGTCCGGAGCCCCACACCGCCAGCTGCGGGGTTTCAGCCGCTGCTCAATG
GAAGCTTGGTTCCCGTGCCGCCCACTACTCCTGCGCCGGGAGTGCAGCTGGACGTGGAGGCTCTCATCCCCACGCACGATGAGCAGGGCC
GGCCCATCCCCGAGTGGAAGCGCCAGGTGATGGTGCGCAAGATGCAGCTGAAGATGCAGGAGGAGGAGGAGCAGAGGCGGAAGGAGGAGG
AGGAGGAGGCCCGGCTGGCCAGCATGCCCGCCTGGAGGCGGGACCTCCTGCGGAAGAAGCTGGAAGAAGAGAGGGAGCAGAAGCGGAAAG
AGGAGGAGCGACAGAAGCAGGAGGAGCTGCGGCGGGAGAAGGAACAGTCAGAGAAGCTGCGGACGCTGGGCTACGATGAGAGCAAGCTGG
CGCCCTGGCAGCGACAGGTCATCCTGAAGAAGGGGGACATCGCTAAGTACTAGAGGCCGCAGACTCCTGTCCGCAGCCTCGCAGCTCCGT
GGGGCCCTCCGCCCCAGCCCCAGCCAGCCAGGCCCTGGTGGAAAGGCTGGGAGCCGCACAGCCCTCCCCTCCTGCGCTGGAAACCCTCCC
TGACCCCCACCCTGGCCCCCCGTATCCCCAGCCCTTGGCAACACTGGAGTGCACACGCCGCCACGGTTGCCCAGAAAAAGTGCCCAAGCT
GCTGACGCAAACAACAACAAATGCTGCTTATTTGCATGCCGACTTACATATATTTGCATGTTCGTTGACTATCAAAGAGTGCAGAGCTCT
CCCCAGCCCCGTGGGTGGTGACTTTGTTTTCCTGCGGGGCTCAGCCCCCTCCAGGATGCAGCCCCCTCCCCCGCACCCCGGAACCGGCGT
CGCTGGCGCATCCTGGGTGGAGGCAGGCCCCGAGCTCGGGGAAGGGGTTTTCCCTTCCTCTCTGACCCAGATCTGCGCGCGGCCTAGCCC
GGGCCTCATTTCTTATCCCCGCCAAGGGTTTCCTCTCAGTCATTTGTTTACCAGAAACATGAAAACTGCCTGTCTGGCCGGGCCGCACTT
GTGGCCCCCGGGACCCCACCTCTGGCCCCACCTCCCTCAAGTCTGCGCCCCGTCCCCAGCCAGACCCACTCGCTGCCGGGACCCTTTCAC
TGCCCCGGTGGAGTGAATAGAGGATGAGGGGCCCTGACCCTGTGTCTCCAACTGCTGCACCCCATCCCGACCCTGTCTCCGCCACCTCGC

>100448_100448_1_ZBTB48-ESPN_ZBTB48_chr1_6647351_ENST00000377674_ESPN_chr1_6488286_ENST00000377828_length(amino acids)=1206AA_BP=450
MWRRRSRGPVGPAQGGPAWELSLAYPRLGWPGCHFCLPALQTMDGSFVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCS
HFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKTSVGQAAGGQSGLGPPASQNV
NSHVKEPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSPAQSEGPSSLCGKLKQALKPCPLEDKKPEDCKVPPRPLEAEGAQLQGGS
NEWEVVVQVEDDGDGDYMSEPEAVLTRRKSNVIRKPCAAEPALSAGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNRKHTGEKP
FECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHA
DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT
QYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGGTPLHD
AAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNF
DLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPPPPPGTQLPPPPPGYPAP
KPPVGPQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHSEEVRARQP
ARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTG
STKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTP
APGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWRRDLLRKKLEEEREQKRKEEERQKQEELR

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Fusion Gene PPI Analysis for ZBTB48-ESPN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZBTB48-ESPN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZBTB48-ESPN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource