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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZC3H15-NCKAP1 (FusionGDB2 ID:100539)

Fusion Gene Summary for ZC3H15-NCKAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H15-NCKAP1
Fusion gene ID: 100539
HgeneTgene
Gene symbol

ZC3H15

NCKAP1

Gene ID

55854

10787

Gene namezinc finger CCCH-type containing 15NCK associated protein 1
SynonymsHT010|LEREPO4|MSTP012HEM2|NAP1|NAP125|p125Nap1
Cytomap

2q32.1

2q32.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 15DRG family-regulatory protein 1likely ortholog of mouse immediate early response erythropoietin 4nck-associated protein 1membrane-associated protein HEM-2
Modification date2020031320200327
UniProtAcc.

P55160

Ensembl transtripts involved in fusion geneENST00000468120, ENST00000337859, 
ENST00000544130, 		ENST00000360982, 
ENST00000361354, ENST00000478449, 
Fusion gene scores* DoF score7 X 5 X 6=21014 X 14 X 8=1568
# samples 817
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1568*10)=-3.20531890797751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZC3H15 [Title/Abstract] AND NCKAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZC3H15(187360061)-NCKAP1(183888644), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZC3H15

GO:0043547

positive regulation of GTPase activity

23711155

TgeneNCKAP1

GO:0016601

Rac protein signal transduction

21107423

TgeneNCKAP1

GO:2000601

positive regulation of Arp2/3 complex-mediated actin nucleation

21107423


check buttonFusion gene breakpoints across ZC3H15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCKAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8530-01AZC3H15chr2

187360061

+NCKAP1chr2

183888644

-


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Fusion Gene ORF analysis for ZC3H15-NCKAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000468120ENST00000360982ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
3UTR-3CDSENST00000468120ENST00000361354ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
3UTR-intronENST00000468120ENST00000478449ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
5CDS-intronENST00000337859ENST00000478449ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
5UTR-3CDSENST00000544130ENST00000360982ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
5UTR-3CDSENST00000544130ENST00000361354ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
5UTR-intronENST00000544130ENST00000478449ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
In-frameENST00000337859ENST00000360982ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-
In-frameENST00000337859ENST00000361354ZC3H15chr2

187360061

+NCKAP1chr2

183888644

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337859ZC3H15chr2187360061+ENST00000361354NCKAP1chr2183888644-2027040422736821151
ENST00000337859ZC3H15chr2187360061+ENST00000360982NCKAP1chr2183888644-450840422736821151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337859ENST00000361354ZC3H15chr2187360061+NCKAP1chr2183888644-0.0001708510.9998292
ENST00000337859ENST00000360982ZC3H15chr2187360061+NCKAP1chr2183888644-0.000411210.9995888

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Fusion Genomic Features for ZC3H15-NCKAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZC3H15-NCKAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:187360061/chr2:183888644)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCKAP1

P55160

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). {ECO:0000250|UniProtKB:Q8K1X4, ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648, ECO:0000303|PubMed:20969869}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCKAP1chr2:187360061chr2:183888644ENST00000360982132995_1015421135.0TransmembraneHelical
TgeneNCKAP1chr2:187360061chr2:183888644ENST00000361354031995_1015361129.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZC3H15chr2:187360061chr2:183888644ENST00000337859+210218_28559427.0Coiled coilOntology_term=ECO:0000255
HgeneZC3H15chr2:187360061chr2:183888644ENST00000337859+21061_8659427.0Coiled coilOntology_term=ECO:0000255
HgeneZC3H15chr2:187360061chr2:183888644ENST00000337859+210174_21259427.0Zinc fingerC3H1-type 2
HgeneZC3H15chr2:187360061chr2:183888644ENST00000337859+21099_12659427.0Zinc fingerC3H1-type 1


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Fusion Gene Sequence for ZC3H15-NCKAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100539_100539_1_ZC3H15-NCKAP1_ZC3H15_chr2_187360061_ENST00000337859_NCKAP1_chr2_183888644_ENST00000360982_length(transcript)=4508nt_BP=404nt
TGGGCGCGCACGCGCAGCTCCGCTTCCGGGAGCCGCTCCTCGCTACCCACTATGCTCTGCGACATCGACCTGTCGCAAAGGCCGCGTTTG
CGGGGCCAATGAGCGACTCGCTTTCCGTGCGGTGCGGCGAGTGAGGCCCCGGTCTTCCTCCTCGTCCTGCCGCAGGGCCAGAACCCCTGA
CGGTATTCAGCTGCGCGTAAGTCTGGCCGGTGCCATCTGTCTCCGCAATGCCCCCCAAGAAACAGGCTCAGGCCGGGGGCAGCAAAAAGG
CGGAGCAAAAAAAGAAGGAGAAGATTATCGAAGACAAAACTTTCGGTTTGAAGAATAAGAAAGGAGCAAAGCAACAGAAGTTTATCAAGG
CTGTCACACATCAAGTTAAATTTGGTCAACAAAATCCACGTCAGGCATGTGGAGACCCCAAGGCAAAACCATCCTATCTTATCGACAAAA
ACCTGGAATCTGCTGTGAAATTCATAGTCAGAAAATTCCCTGCTGTAGAAACCCGCAACAACAATCAACAGCTTGCACAACTACAGAAAG
AAAAATCAGAGATTCTGAAAAATCTGGCATTATATTACTTCACATTTGTAGATGTTATGGAATTTAAGGACCATGTTTGTGAATTGCTGA
ATACTATTGACGTTTGCCAAGTCTTCTTTGATATTACTGTAAACTTTGATTTAACAAAGAACTACTTAGATTTAATTATAACCTATACAA
CACTAATGATACTGCTGTCTCGAATTGAAGAAAGGAAGGCAATCATTGGATTATACAACTATGCCCATGAAATGACTCATGGAGCAAGTG
ACAGAGAATACCCACGCCTTGGCCAGATGATTGTGGATTATGAAAACCCTTTAAAGAAGATGATGGAAGAATTTGTACCCCATAGCAAGT
CTCTTTCAGATGCACTAATTTCTCTTCAAATGGTATATCCTCGAAGGAATCTTTCAGCTGACCAGTGGAGAAATGCCCAGTTATTGAGCC
TCATCAGTGCACCTAGTACAATGCTTAATCCAGCACAGTCCGACACTATGCCTTGTGAATACCTCTCTTTGGATGCAATGGAAAAGTGGA
TTATCTTTGGCTTTATTTTGTGCCATGGGATCCTAAATACTGACGCTACAGCACTGAACCTTTGGAAACTAGCTCTTCAAAGTAGCTCTT
GCCTCTCTCTCTTTCGGGATGAAGTTTTCCACATTCACAAAGCTGCAGAAGACTTATTTGTAAACATACGAGGCTATAATAAACGTATTA
ATGACATAAGAGAATGCAAGGAGGCAGCCGTGTCACATGCTGGTTCAATGCACAGAGAAAGACGCAAGTTTTTAAGATCTGCACTGAAGG
AATTGGCTACTGTCCTCTCTGATCAACCTGGATTGCTAGGTCCCAAGGCACTTTTTGTTTTTATGGCATTATCCTTTGCCCGTGATGAAA
TCATCTGGCTACTTCGTCATGCAGATAACATGCCAAAGAAGAGTGCAGACGACTTTATAGATAAGCACATTGCTGAATTAATATTTTACA
TGGAAGAACTTAGAGCACATGTGAGGAAATACGGACCTGTAATGCAGAGGTATTACGTGCAGTACCTTTCTGGCTTTGATGCTGTTGTCC
TCAATGAACTCGTGCAGAATCTTTCTGTTTGCCCTGAAGATGAATCAATCATCATGTCCTCTTTTGTTAACACTATGACTTCCCTAAGTG
TAAAACAAGTTGAAGATGGGGAAGTATTTGATTTCAGAGGAATGAGATTAGATTGGTTTAGGTTACAGGCATATACTAGTGTCTCAAAGG
CTTCACTTGGCCTTGCAGATCACAGAGAACTTGGAAAGATGATGAATACAATAATTTTTCATACAAAAATGGTAGATTCCTTGGTGGAAA
TGTTGGTGGAAACATCAGATCTCTCCATATTTTGTTTTTATAGTCGTGCTTTTGAGAAGATGTTTCAACAGTGTTTGGAGTTACCCTCTC
AATCAAGATACTCAATTGCATTTCCACTACTTTGCACTCATTTTATGAGTTGCACGCATGAACTATGTCCAGAAGAGCGACATCATATTG
GAGATCGCAGTCTTTCCTTATGTAATATGTTCCTAGATGAAATGGCCAAACAAGCTCGAAATCTCATCACTGATATTTGCACAGAACAGT
GTACCCTTAGTGACCAGTTGCTACCCAAGCATTGTGCCAAAACTATCAGTCAAGCAGTGAATAAGAAATCAAAAAAGCAGACTGGTAAGA
AAGGGGAACCTGAAAGGGAGAAACCAGGTGTTGAGAGCATGAGGAAAAACAGGCTGGTTGTGACCAACCTTGATAAATTGCACACTGCAC
TTTCTGAGTTATGCTTCTCTATAAATTATGTACCAAACATGGTGGTATGGGAACATACCTTTACCCCACGAGAATATTTGACTTCTCATC
TGGAAATACGCTTTACCAAGTCAATTGTTGGGATGACTATGTATAATCAAGCCACACAGGAAATTGCAAAACCTTCAGAACTTCTAACAA
GTGTAAGAGCATACATGACCGTACTCCAGTCAATAGAAAACTATGTGCAGATTGATATTACAAGAGTATTTAATAATGTGCTTCTTCAAC
AAACACAACATTTAGACAGTCATGGAGAGCCAACCATTACAAGTCTATACACAAATTGGTATTTGGAAACTTTGTTACGACAAGTCAGCA
ATGGCCATATAGCATATTTTCCTGCAATGAAAGCGTTTGTGAACTTACCTACAGAAAATGAATTAACATTCAATGCAGAGGAATATTCTG
ACATATCAGAAATGAGGTCATTATCAGAACTACTAGGCCCATATGGTATGAAGTTTCTAAGTGAAAGCCTTATGTGGCATATTTCATCAC
AAGTTGCTGAACTTAAGAAACTTGTGGTGGAGAATGTTGATGTGTTAACACAAATGAGGACCAGCTTTGACAAACCAGACCAGATGGCTG
CACTGTTTAAAAGATTATCATCTGTTGACAGTGTCTTGAAGAGGATGACAATAATTGGTGTAATTTTATCCTTCCGATCATTGGCACAAG
AAGCACTTAGAGATGTCTTATCCTACCACATTCCTTTTCTTGTAAGTTCAATTGAAGATTTTAAGGATCACATTCCAAGGGAAACTGATA
TGAAGGTTGCAATGAATGTGTATGAGTTATCATCAGCTGCCGGATTACCTTGTGAGATTGATCCTGCATTGGTCGTAGCTCTTTCTTCAC
AAAAATCGGAAAACATTAGTCCAGAAGAAGAGTATAAAATTGCCTGCCTTCTCATGGTGTTTGTGGCAGTTTCTTTGCCAACACTGGCCA
GTAATGTGATGTCTCAGTACAGCCCTGCTATAGAAGGGCATTGCAACAACATACATTGCTTGGCCAAAGCCATCAACCAGATTGCTGCAG
CTTTGTTTACAATTCACAAAGGAAGCATTGAAGACCGTCTTAAAGAATTTCTGGCGCTTGCATCCTCCAGTCTACTGAAAATTGGCCAGG
AGACAGATAAAACTACAACAAGAAATAGAGAATCTGTTTATTTACTGCTAGATATGATTGTACAAGAATCTCCATTCCTTACAATGGATC
TTTTGGAATCTTGTTTTCCTTATGTCTTGCTGAGAAATGCATACCATGCTGTCTACAAACAAAGTGTTACATCTTCTGCATAAAATTACC
TACTTAATCAAGATAAGCACGCATTTTTGTTGCCTTGGTTTTACCTGTAGACTGTGGAACTATTTTACCTTAAGACCTGAAAAAGTTTTG
TGGATTATAAATTTCTTTCATACGGTTGTATTTTCTGATCATTGGTTTCTTAATATGGTTGTACTACAGTATACTTGGTTGATTTAGGTT
GCACATTCACTGAATTCACTGAGATTATTCCTATAATTTTAAAGTATCATTTATTTGAAAAACATACATTATCAACATGTTTTTGATATT
TGATAATGAAAAAAATCTTTGCTTGTTTATTTCTGAAAAAGAACTGTATTTAGTGATTATTTTAGATAGTGATATTATAGTATTCATCTG
TGTGTAAATTATTTCATATAGGGAAGAGTTCTGATCTGTACCTATGGTTCTTATTGAAAACAACATTGGATGTGCATTTCTGTGATGTTA
TGAATACATTTCTACTTTATTTTGAAACATTTGCCAAACTAAATACTGTAACACTGTATAACATTTAAAAATGTTAAAGAACTGCTTAGT
ATTAGAAGCAGATCATTTCCCAAAATTCTAAGAGCAGCAGCATATGTTGTTGCTTGTATAAAGCCTAGCGATAATTTTTAGACTAACTTC
CATGGTGCCCTGTTGGCATTAGCACTACCATTGTACCCTGCTGTATAATAAACAATCTTAGACATTTATCAACTGTTGATACAAATGTTA
GTCCCTAACCACTTTTTATATATGTTTTAAATTTTTGAAATTCAAGTGTACCTGCCATAACATAAAATAAACACTAGACTGTATCACACT

>100539_100539_1_ZC3H15-NCKAP1_ZC3H15_chr2_187360061_ENST00000337859_NCKAP1_chr2_183888644_ENST00000360982_length(amino acids)=1151AA_BP=59
MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQACGDPKAKPSYLIDKNLESAVKFIVRKFPAV
ETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAII
GLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDT
MPCEYLSLDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGS
MHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQ
RYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMN
TIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMA
KQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVV
WEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSL
YTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVL
TQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGL
PCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKE

--------------------------------------------------------------
>100539_100539_2_ZC3H15-NCKAP1_ZC3H15_chr2_187360061_ENST00000337859_NCKAP1_chr2_183888644_ENST00000361354_length(transcript)=20270nt_BP=404nt
TGGGCGCGCACGCGCAGCTCCGCTTCCGGGAGCCGCTCCTCGCTACCCACTATGCTCTGCGACATCGACCTGTCGCAAAGGCCGCGTTTG
CGGGGCCAATGAGCGACTCGCTTTCCGTGCGGTGCGGCGAGTGAGGCCCCGGTCTTCCTCCTCGTCCTGCCGCAGGGCCAGAACCCCTGA
CGGTATTCAGCTGCGCGTAAGTCTGGCCGGTGCCATCTGTCTCCGCAATGCCCCCCAAGAAACAGGCTCAGGCCGGGGGCAGCAAAAAGG
CGGAGCAAAAAAAGAAGGAGAAGATTATCGAAGACAAAACTTTCGGTTTGAAGAATAAGAAAGGAGCAAAGCAACAGAAGTTTATCAAGG
CTGTCACACATCAAGTTAAATTTGGTCAACAAAATCCACGTCAGGCATGTGGAGACCCCAAGGCAAAACCATCCTATCTTATCGACAAAA
ACCTGGAATCTGCTGTGAAATTCATAGTCAGAAAATTCCCTGCTGTAGAAACCCGCAACAACAATCAACAGCTTGCACAACTACAGAAAG
AAAAATCAGAGATTCTGAAAAATCTGGCATTATATTACTTCACATTTGTAGATGTTATGGAATTTAAGGACCATGTTTGTGAATTGCTGA
ATACTATTGACGTTTGCCAAGTCTTCTTTGATATTACTGTAAACTTTGATTTAACAAAGAACTACTTAGATTTAATTATAACCTATACAA
CACTAATGATACTGCTGTCTCGAATTGAAGAAAGGAAGGCAATCATTGGATTATACAACTATGCCCATGAAATGACTCATGGAGCAAGTG
ACAGAGAATACCCACGCCTTGGCCAGATGATTGTGGATTATGAAAACCCTTTAAAGAAGATGATGGAAGAATTTGTACCCCATAGCAAGT
CTCTTTCAGATGCACTAATTTCTCTTCAAATGGTATATCCTCGAAGGAATCTTTCAGCTGACCAGTGGAGAAATGCCCAGTTATTGAGCC
TCATCAGTGCACCTAGTACAATGCTTAATCCAGCACAGTCCGACACTATGCCTTGTGAATACCTCTCTTTGGATGCAATGGAAAAGTGGA
TTATCTTTGGCTTTATTTTGTGCCATGGGATCCTAAATACTGACGCTACAGCACTGAACCTTTGGAAACTAGCTCTTCAAAGTAGCTCTT
GCCTCTCTCTCTTTCGGGATGAAGTTTTCCACATTCACAAAGCTGCAGAAGACTTATTTGTAAACATACGAGGCTATAATAAACGTATTA
ATGACATAAGAGAATGCAAGGAGGCAGCCGTGTCACATGCTGGTTCAATGCACAGAGAAAGACGCAAGTTTTTAAGATCTGCACTGAAGG
AATTGGCTACTGTCCTCTCTGATCAACCTGGATTGCTAGGTCCCAAGGCACTTTTTGTTTTTATGGCATTATCCTTTGCCCGTGATGAAA
TCATCTGGCTACTTCGTCATGCAGATAACATGCCAAAGAAGAGTGCAGACGACTTTATAGATAAGCACATTGCTGAATTAATATTTTACA
TGGAAGAACTTAGAGCACATGTGAGGAAATACGGACCTGTAATGCAGAGGTATTACGTGCAGTACCTTTCTGGCTTTGATGCTGTTGTCC
TCAATGAACTCGTGCAGAATCTTTCTGTTTGCCCTGAAGATGAATCAATCATCATGTCCTCTTTTGTTAACACTATGACTTCCCTAAGTG
TAAAACAAGTTGAAGATGGGGAAGTATTTGATTTCAGAGGAATGAGATTAGATTGGTTTAGGTTACAGGCATATACTAGTGTCTCAAAGG
CTTCACTTGGCCTTGCAGATCACAGAGAACTTGGAAAGATGATGAATACAATAATTTTTCATACAAAAATGGTAGATTCCTTGGTGGAAA
TGTTGGTGGAAACATCAGATCTCTCCATATTTTGTTTTTATAGTCGTGCTTTTGAGAAGATGTTTCAACAGTGTTTGGAGTTACCCTCTC
AATCAAGATACTCAATTGCATTTCCACTACTTTGCACTCATTTTATGAGTTGCACGCATGAACTATGTCCAGAAGAGCGACATCATATTG
GAGATCGCAGTCTTTCCTTATGTAATATGTTCCTAGATGAAATGGCCAAACAAGCTCGAAATCTCATCACTGATATTTGCACAGAACAGT
GTACCCTTAGTGACCAGTTGCTACCCAAGCATTGTGCCAAAACTATCAGTCAAGCAGTGAATAAGAAATCAAAAAAGCAGACTGGTAAGA
AAGGGGAACCTGAAAGGGAGAAACCAGGTGTTGAGAGCATGAGGAAAAACAGGCTGGTTGTGACCAACCTTGATAAATTGCACACTGCAC
TTTCTGAGTTATGCTTCTCTATAAATTATGTACCAAACATGGTGGTATGGGAACATACCTTTACCCCACGAGAATATTTGACTTCTCATC
TGGAAATACGCTTTACCAAGTCAATTGTTGGGATGACTATGTATAATCAAGCCACACAGGAAATTGCAAAACCTTCAGAACTTCTAACAA
GTGTAAGAGCATACATGACCGTACTCCAGTCAATAGAAAACTATGTGCAGATTGATATTACAAGAGTATTTAATAATGTGCTTCTTCAAC
AAACACAACATTTAGACAGTCATGGAGAGCCAACCATTACAAGTCTATACACAAATTGGTATTTGGAAACTTTGTTACGACAAGTCAGCA
ATGGCCATATAGCATATTTTCCTGCAATGAAAGCGTTTGTGAACTTACCTACAGAAAATGAATTAACATTCAATGCAGAGGAATATTCTG
ACATATCAGAAATGAGGTCATTATCAGAACTACTAGGCCCATATGGTATGAAGTTTCTAAGTGAAAGCCTTATGTGGCATATTTCATCAC
AAGTTGCTGAACTTAAGAAACTTGTGGTGGAGAATGTTGATGTGTTAACACAAATGAGGACCAGCTTTGACAAACCAGACCAGATGGCTG
CACTGTTTAAAAGATTATCATCTGTTGACAGTGTCTTGAAGAGGATGACAATAATTGGTGTAATTTTATCCTTCCGATCATTGGCACAAG
AAGCACTTAGAGATGTCTTATCCTACCACATTCCTTTTCTTGTAAGTTCAATTGAAGATTTTAAGGATCACATTCCAAGGGAAACTGATA
TGAAGGTTGCAATGAATGTGTATGAGTTATCATCAGCTGCCGGATTACCTTGTGAGATTGATCCTGCATTGGTCGTAGCTCTTTCTTCAC
AAAAATCGGAAAACATTAGTCCAGAAGAAGAGTATAAAATTGCCTGCCTTCTCATGGTGTTTGTGGCAGTTTCTTTGCCAACACTGGCCA
GTAATGTGATGTCTCAGTACAGCCCTGCTATAGAAGGGCATTGCAACAACATACATTGCTTGGCCAAAGCCATCAACCAGATTGCTGCAG
CTTTGTTTACAATTCACAAAGGAAGCATTGAAGACCGTCTTAAAGAATTTCTGGCGCTTGCATCCTCCAGTCTACTGAAAATTGGCCAGG
AGACAGATAAAACTACAACAAGAAATAGAGAATCTGTTTATTTACTGCTAGATATGATTGTACAAGAATCTCCATTCCTTACAATGGATC
TTTTGGAATCTTGTTTTCCTTATGTCTTGCTGAGAAATGCATACCATGCTGTCTACAAACAAAGTGTTACATCTTCTGCATAAAATTACC
TACTTAATCAAGATAAGCACGCATTTTTGTTGCCTTGGTTTTACCTGTAGACTGTGGAACTATTTTACCTTAAGACCTGAAAAAGTTTTG
TGGATTATAAATTTCTTTCATACGGTTGTATTTTCTGATCATTGGTTTCTTAATATGGTTGTACTACAGTATACTTGGTTGATTTAGGTT
GCACATTCACTGAATTCACTGAGATTATTCCTATAATTTTAAAGTATCATTTATTTGAAAAACATACATTATCAACATGTTTTTGATATT
TGATAATGAAAAAAATCTTTGCTTGTTTATTTCTGAAAAAGAACTGTATTTAGTGATTATTTTAGATAGTGATATTATAGTATTCATCTG
TGTGTAAATTATTTCATATAGGGAAGAGTTCTGATCTGTACCTATGGTTCTTATTGAAAACAACATTGGATGTGCATTTCTGTGATGTTA
TGAATACATTTCTACTTTATTTTGAAACATTTGCCAAACTAAATACTGTAACACTGTATAACATTTAAAAATGTTAAAGAACTGCTTAGT
ATTAGAAGCAGATCATTTCCCAAAATTCTAAGAGCAGCAGCATATGTTGTTGCTTGTATAAAGCCTAGCGATAATTTTTAGACTAACTTC
CATGGTGCCCTGTTGGCATTAGCACTACCATTGTACCCTGCTGTATAATAAACAATCTTAGACATTTATCAACTGTTGATACAAATGTTA
GTCCCTAACCACTTTTTATATATGTTTTAAATTTTTGAAATTCAAGTGTACCTGCCATAACATAAAATAAACACTAGACTGTATCACACT
TCGATTGATTTCTTTAAGATCCTTGGATATTCGTTCAATAATAATAAAGTTTTTGTTTAAACTTAGTTTGAAATATAAAAAATAATGGTT
TAGGAATGTCTAAGTACAGCATTCGATACCAGGTCAGCTATTATATGATTTGTTTAAATGTTTTAAAAAACATTTTATTGAAAAAAATAC
CAAAATTAGAAAATAAAATTACACAATACTTCTTAAAAATTAAGAACTTAAAGAAAACTTGTATGCTGTCAACTTGCTCATTTTATCTGT
AACCAAATAGAGTTATTTAAAAGAATAGGGAAAAAAAATTGAGTGATCATGGGACTAGTGAGAATGTTGAGAACTGCTGCATTAGTCAGT
AATGAATGGGAAAGACATAAAAGGGCCTATTGCTTAATAGTTGGCATGGAGGGCAAAGCAGCTCATTTAGTTTGAAAACTAACCCAATGT
TTTGCTCTTTGATTGGCATTGTTGAGGCTGTTTCTCAGCAGCTTTGTATATGAATATCATAAAGAGCTTCTGTTCACAGCTTCTTATGTA
TACACTGGTAACTTGTGTTAAGATAAAAGAAGGCTGCTGTGAACTCAGTTATAATGTTTTTCTTTCTTCAAACATAGAGAGTAGAATGAA
ATTGAAGTACTATGAGATTATGCTATTATTTTGTGTATGATTTGTCCAGCCTATATTTAAAGTAGGGAGTAGTTGTCACTATCTGTCGAA
AAATTGTACTTGTTCCATAAAGATTTTTTAAAAAGGGAAATTTTAAAATGGCATAGTTCAGACCTGAAATAGTCTGATTTACACAGTGAG
CAGTCAAAACTAAGATTTAATGCCGTTTGTTTTGAAATATTAGGATCTTAGAGAGGTAATAACTTTGTTGGCAGTGATCTCTGGAGAGGT
AAAGTAGGAATTTGGATATGTACACTTTGGAATCATATGTGAAAGGGCATAAGGATGAAAATAAGGCATTCTCTACCACTGCTAGGCTGA
GAAAAAAATCGCTCCTCATAGTCACCTGAAGTTTTTGTCCAAATTTTTTCTCATACAGCAAAGGCGGGGGAGGAGGCGTGGCAAAGGTAA
CTTGGAGGAAAAAGTTAAAAGTAAATTGACAACTACTATTTTTAATATCTTGTTTGTTTTATTTTCTTCTAAACTTACACAACAACATAC
TATTTTTGTTGTTTTCTCTACATTAATGTGATCATACCATACATACTGGCCTGTAATCTGCTTATTTCACTCAGTAGTAGAAAAAATGTC
TTTAATATTCTTTTTAATACCTTTATAGATACCATAACTAATTTAACAATTTCATGGCCAGGCGTAGTGGCACACGCCTATTTCAGCACT
TTGGGAGGCCAAGGCGGATGGATCACTTGAGGTCAGGAGTTCAACACCAGCCTGGCCAACATGGCAAAACCCTGACACTACTAAAAATAC
AAAAATTACCCAGGTATGATGGTGCACACCTATCATCCTGGCTACATGGGAGGCTGAGGTGGAAGAATTGTTTGAACCCGGAAGGAGGAG
GTTGCTGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGATGACAGAATGAGACTGTCTCAAAAAAAAAAAGAAAATACTCATTTGGA
TAGATTGGATAGATTTTTAGACAATTTCTTTTCATTATTATAAATGTATATCTATATCTTGGTAAAGTTGACCTGTTATTTTTTTAGAAT
AATTTTTCAGAAGTAAAATTGCTTCCTTTCTGCTGCTTTTTCATTCACTTATTTAAGCAAGTATTTTTAGATGCCTGCATGTAATGGTGA
GCAAAAAGGTGACCCTTTTATAGTTGAGCTTGGATTTTAGTGATGGTATACAATAAACAAACCAGCTTCTTGAGACGGAGTTTCACTCTT
GTTGCCCAGGAAATGGGCAATGGCCTGATCTCGGCTCACTGTAACCTCCGCCTCCCGGGTTCAAGCAATTCTCCCATCTCAGCCTCCTGA
GTAGCTGAGATTACAGGCGCCCGCCACTACGCCCAGTTAATTTTTGGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGGCCAGGCTGG
TCTCGAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCATGAGC
AAACTTCTGATGGTGACTGGAAAGTATACAGGATAATGTGGGGAGGCAGTGGTGAAACTACTTTAGAAGAAAGTGTTAGAAGAAAGTGTC
ATCTGTGTAAGAGAAAACATTTGAGCTGGTACGTGAAGGATTAGAAGGAACCACAAGTGGGCTGAGGGGAGGAATAATAAAGGCAAAGAC
CCAGAAGGCAAGCACAAACTTGGCATGTTTGAGAAGTTAGAAGTGTGTCATCTGTGTCTCTGTCATGAGGAGTGCTCAAGTTCCCTCTAG
GAGCCTTATGGGCTATCTAGCTCTTTTTCTCTTCTGATCATGTGCTTGCTTGCTTTCTTCTTTGCTTATATAGCAGAGTTCACAAATTAA
ATCTAATGTAGGCTGGTTAATAAAGGAAATGAACATGAATTCACTGATAGGCTCTTGCATTAATGTGAAAATGTAAAGTCTGTTGTACAC
CATCAGGCCTTCTAAATGAAGCCCAAATTCTGTAAGGTAGTGAATTGTAACCTACTGATTAGTACATGATCCATGCCCATTCTGTTATAA
GGACTTGCCTTTCTGAGACTTCACCTGTATTATTCCTAAGACTTTTGTGAATAATCCTTAAAGTAGTGACTCCTTACATCTTTCTTTCAT
TTCTTCTTTGTAGTCACTTGAAATGACAGCATGAACCATCATTTCATTTGAAGGCCTGAGCCTGAATTTTCAAATAGACAAAATGCTCTC
TTTCTCCGAAGATTTGCCATGACCTCTGCCTTTGGGAAAAAATATTTGAGATTTTAAAATTTTTATTCTGTAGTACAAAAATTATGTTTT
TCGTTAATTGGTCCTGTGGAATTGGAAGGAAATTTAATATTTATTGACTCTACTTTGGTATTATTTTCAGAGTGAGAAGTAACTTTAAGT
GTATTAAAATTTCATTCATTTTTGCATGAACCAAACTTTCCCTACACATCGCTGTCCTTGACTGTCCAGAGTAAACATGTCTAACTCTGG
AATGTTTCATTTCCAATAAAAGTATTCAGCCTGTCATTTTGGGCCTAAGTAAAATGGGATAAATTAGCAATCTGAAGTTAGGATCCTAGC
CACAGAGGGCCATGTCTCATTTCTGGTTTAAGTGCACCCCTCATCCCCAGCCCTTACCTTCTTCTTTCTCTTAAGGATTGAGACAATCCT
CTTGGTGCTCTTGGTGCAGGTGCATCTTGGTCACCTCTTACATGAGGGCCACAAACTTGGTAAATGGGTGGCCTGGAGATGGGGTTGTAC
TAGGTATGTGACCTTGGTGATTGCCTTGTCTCAGTTGTAGTATATGGCTGAGTCACATTCATAGTACACTACATACACATACTGACCAAA
TGCCAATGGCTAAGGCTTGAAATTATTTCACCAAGACCTAAACTGAAGATTACCATCATAAAATAAGCTTCTAGAATCCATGAATAAGTA
GGAAATCATATTTAAAATTTACTGTAATTTTATTAAAGCTCATTTTTTAAATTTAATGCAGTGCAGAGTCATTAATTTCTCAGCAGTATC
AGGTGCTAAATTGCTCACTCATTAAACTACTAATTTAAGATAGTTATTTTAAATTATAGAACAGGAAGCAACTTACGAGGTTGCAACCAA
ATTATATTTATTTTTTCTCCATTAGTAACTGACTAAAAGTGTTTTCTTCAACTCTGGGATTTGAAGATTTTGTGGTCAGTGGTGATATAA
TTTCACTGAAGCGTGCTCACAGACTAAAACTGTGCACTACTCAGTGATGCGTCCTGAATGTTTTCAGAGACAAACCTAAGATAATGTTGC
CCTTGTTTACTTTCATTATTTCTGATTTTTTTTTTATGCATGTGTTTGCTGCATCACACAATTACTTAAGAAGTTGTCCCTAACCTTTGT
GCTGTGGTCTGAATGTTTGTGTCCCCCTGGCCACAAAATTCATATGTTGAAATCTGATCATCAGTGTGACAGGATGTGGGGCCTTTGGGA
GGTGATTAGGTCATGAGAGTGGAGCCTTCATGAATGGGATTAATGCCCTCGTAAAAGGGGCCCCAGACAGCCGACTTGCCCCAACCACCA
CGTGAGGACAAAGCAAGAAGCCACTGTTCATGAACCAGAAAGCAGACCCTCCACAAACACCAAATATGCCAGCACACTGATTGGCTTCCC
AGCCTCCAGAACTATAAGCAAGAAGTTTTTTTATAGTAACAAATTTATTGTTCACAGTTCTTGCTTATAAACTTTATAAACCAGACTAAG
GCATTTCGTTATAGCAGCCCACACGGACTCATATTTTGGTTCTAGAAATGTGACACTGGAATGATGTGGCTCTCAAGATGACAGTGTTGC
TTCTGAATGTCTATGTTCATGTCATCTTTAATTGCATGAACACCAGTTTTAGCATCTTCCCTTGAGTAGAAAGAGATTCTCTACAGCAAG
TATTACGTAAGAAGTACTGGTGGCCAGGCACAGTGGTTCACGCCTGTAATCCCAACACTTTGAGAGGCGGAGCCAGAGGTATCATTTGAG
CCTAGAAGTTCGAGAGCAGCCTGGGCAATATGTCTAAACCCCATCTCTACAAAAAAAATACAAAAATGAAAAAGCCGGGTGTGATTGTGT
ACACCTGTAGTCCCAGCAACTTGAGAAGCTGAGGTGGCAGGATTGCTTGAGCCCAAGGGGAGGGTTGGCGGCAGTGGGTGGTTCGAGGCT
GCAGTGAGCCATGATTATACCAGTGCGCTCCAGCCTAGGTGACAGAGCAAGAGCCGGTCTCGATAATAATTAAGGCCAGACGCGGTGGCT
CACTCCTGTGATCCCAGCACTTTGGGAGGCCAAGGTGGATGGATCACCTGAGGTCAAGAGATTGAGACCAACCTGGCCAACATGGTGAAA
CCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCTTTGTGGCTCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCGGGAGAATC
GCTTGAACCCAGGAGGCGGAGATTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAACAAGACTCTGTCTCAAAAA
AAAAAAAAATTATAATACATTAAAAAAAAAAAGCACTTGCATTCTGAAGGCATATTCACCCTTGAACTGATAGCATTCAATGTATAAAAC
ACATGAGTTTCACTCCAAGTTACATATAGAATGTTTATCTTTATTTGAGAGGAAATATCCAGTTAATAATCAGAATGTCATACTAATTAG
GTATGACCATAACTTACGTTAGTCACATGGTCATTGATTGCATGCAGATTCTGGCTGCCAGAAAGCACATTGAAGTAGGTAGTCATTTAA
CCATTTAACTGTTAGATCTTGCAAAGGTTGAAGCTGAAGCTGAGGAGCAGGTAGTACACAACTTTACAGGTTAATGCTGAATGTCAGTTC
ATTCTGAATTCTTACCTTCAGCCAAAAGGTACAAGGGTCTTTGCAGTCTGAAGCAAGGCCCAGATGGCAGAACTTGTGATGGCTAGGAGG
GGAAAATTTGACCTTAACTGGTAGTTGTGGTTTTATCAAGCCAAAAATGCTGACTAGAATAATAATGAGAGCTAATGTTTATTGAAAGCC
CATTGTGTACCAGATACTCTGTTTTCTCTAATTCAAACCTCTAAATATTGCTCTTTTAGTCTTCACAGTAATCCTATATCATGATGACCC
CCATTTATTGATATGGAAACTGAAGCTCAGGAAAGACAAAGCAATTTTTACAAACTCACACTACAAGGAAGTAGCAGAGGCCAACATTTA
AATCTGGCCCCAGAGTTGTGTTCTTCTCATTAAACTGTGTCTCAGATCTCTCAAATGTGAGTGTGGACTTTTCTAACCAATAGCATTTTT
TAATTAATGTTTTAAAAATTTGAATAGCTTTTAGGGTACAGTGGGTTTTTGTTTACATGGATGAATCATACATTGGTGAAGTCTGAGGTT
TTAGTGTACCTGTCACCCAGGTAGTATGCATTGTACCCAATGTGTAGTTTTTTATCCCTAGACCCGTTCCCATCCTCCCACTTCTGAGTC
TCCAAAGTCCATGATATCACTCTGTATGCCTTTGCATACACATAGCTTAGCTCCCACTTACAAGTGAGAACATACGGTATTTGGTTTTCT
GTTCCTGAGTTACTTTGCTTAGAATAATGGCCTCTGGCTCCATCATAGTTGCTGCAAAAAGACATTGTTTCTTTTTTTATGGCTGAACAG
TATTCCGTGGTGTGTATATATACCACACTTTCTTTGTCCACTCATTGGTCAGTGGGCACTTAGGTTGGTTCCATATCTTTGCAGTTATGA
ATTGTGCTGCAATAAATATACACATGCAGATTTTTTTTGATATATTGACTTCCTTTGGGTAGATACCCAGTAGTAGGATTGCTGGATCAA
ATTCTATCCAGTAGCATTTGAAACTGCTTTACATTAACAATGAGGGACAAAAAAAATAACAATGAGGGCTTACATTATGCTACTCTTGAT
ACTAGACATTTTCATATCCATTACTTCATTTAAACTCCACAACCAAATTACTCAATAGGGATTGTTTTCTTTATTTTTGTAAATGAATGT
GGAAACCAGCTCATAAAACTTTAAATTCCTTGCCCCAGTGTCATAAAATTACTGAGTTTGAGTGGCAGTGCTGAGATTAAAACCTAAGGC
TCTAGGATTTCCAGCCCATATTTTTTCTACTGTATCATGTTCTTTCCCAAAGCACTAAAAAACATTTCCTGGGTAAATGACTGTGGGCTT
GGGGACACTATGCCCACTTTCTGGCCTTCATGGGTCTAAGTTGCTTCTTTGCTTCTTCACTTTTTCTCTCTGATCCTGCTCAGATTAATC
TCTAGTAAATCAGATTTCTTTCCTAGGCTGTCTTATCCCACATATATAGTAGATAATATGTCACATATTTGTGAATGTTAAAAATATTTG
TTTTAGTTTTAAATCTCAAGCTCACACAGTACTTACTCTCTATGTTAACAAAAATGGTTTTTACTATTTTCTGAAGGTAACGCAGCTGTT
GAAGTGAGATCCTACACTGGAACATACAACACTTGGTCTAATATTAAAGTTCGTGCCAAGAGCTCTCTAAATGTGATTGATGGATTAATT
CTGCCTTTATGAAAGATGAACTTATTTTCAAGATAATAGCTAATTCTTGAATGGGCAACCTATTATGTATCAATGATTGTAATGATGGAG
CATTTTAGTCATTTGTAGCTGGAAGAGCCTTAGAGATTATCTGGTTCAACCTATTCAAGAGTTAGGTAATTTAACCAAATTAACATATGT
GGCGATGTGCTCATATAGTGTTCCTTCCACTGTGCTGTGTTGCCGCATATATGCTGATCTTATGTTTATGCAGTAATAGTCTTCATAATG
ATAAACAGCTACTGGTTCCTGGTAGGATTTTGGACGTGGATATGACTTGAAGTATGATGCCACAGCCTCAAACAAATCTGGGGTTTGAAT
CCCAGCTCTGTCACTTATGGACAAATTACTTAACTTCTCCAAGTTTGTTTCCCTAAGTGTAGAATGTGGATAATATCTACTTTAAAGGGC
TATTGTAAGCATTAAAATAAGATCATGCGTATAAATTGATGAGATGGTGGGGAAGAAGAGGCTACCACAAAGTAGGCATTCAGTGTAAAT
GGTGGTAGTTTCTCCAGTATTATTAGGCTATTTGGTTTCACTTATAAAATTGCCTTCAAAGAGTTTTTTCATGGCTTTTATGAGTATTAT
AATATCAGAACTTCCACTCATGCAAATGTAACATTTGTGTGTTAGTCTATTCTATAGCTCTGATCGGAGTCTTTATCTTAAATGGGAAAG
ATTATTTTCCCTGTCATGTAACTTTAACAGAAAACGATGCTAAAATTAATTTTAAGACTGCTCTATACTATATGTATGTTATACTATATT
TTTATATACTATACACAAAAATGTATAAGATGTAAAGCTTGTATTTTCAAATGTTATTGCAGTATCCAGAACAATTGCGACAATTGCTCT
TGGAAGCTTCTGTGCTTTTCCACATGCTGTTCCCTGTCTCTGGAATGGAATGTTCTCTTATTCTGGCTGGCAAACTCCTGAACATAATGT
AAACAGTAAGCTCAAACATCACTTGCCCTTTCCTTACCATGCCATCCTGTTTCTTCTAAACCTTATAAATGCCTTTATTATAGTACATAT
TGAATCATAATGTAATTATTATTTATCTCTGACTCCTTTGATTCTGGGACTGCCTTGAGGTCACGGTCTAGGTTTATTTCATCTTTCTGT
CTGTTTAGTCAAATTTCCTACCCTGTGTAACTCTCAGAATCTTACTTTAAGTTAGGAAAGGCCAGTGGCTGGACAGATGCTACAGACCTC
CATTGGTACAGATGCCCTTAGCTTCATGTTGGGAACAAGTGGTTCTGTTTCTTTTTGTTCCTGTGGAGAAGCATCAGAGATACAGGCAGC
TGGGGATTTCTACACCTGTAATAGCAGCAGCTCAGTGATGACACAGAGACATGTTTTTTTTTTTTTTTTTTTTTTGACAGAAGGCGAAGG
GGAAGCAAGGTACTTCTTACATGGCAGAGGGAAAAGGAGAGTTGGAGTGGGGGAGGGGGAGAGGGAGGAGCAGGAGCAGGGAGACGGGGA
GGGAGAGGAAACTGCCCCGAAGACATGGTTTCTAAGATTTCTCCCAATGAGACAAATCACTTGTCTGGGATGTCAGGGGGAGAAGATGCA
GAATCTGAGCCCCTTGTATAAATAGACAAAAGGTGAAAGCATTGGCAATAGATCAAAAAGGCATTCCACGTAGCAAAAAAATTATTTTTA
AATCTGAAAATTTAAGTGAAATGCCAAGAGCAAAGAAGAGAGGCCATCAGAAAAATTTCAAAGTGACTACTCAGGTCATTGTCCTGAAAT
AAATGATCATTTTATTCTGGTGACTCACCCCTAGCTAGAGTCAGTACTTCATAGAAAAGACAGGAGCTGTGAGACACTTAACTGTAATCT
TACCCCTTTACAGAAATGCCTCCTATAGTCAAGCTGGTCTGATGATCTCATGTCATCATGCACAAGGATTAGCAAGCCTTGAAATTTTAT
CCTGTCAGTGTAACTCCTCATCTAGTCTCAAGATTGCACTGGCAGTTCTTTCGCAGCTGATCGTACAGGGAGGACCAATAAGGCTCATAG
AACACCCTTGGAGAATGAATGCCTCTGCTGCTGGAGGTCACAGCACCCAGAAAGTGACTAGAGGGAGCAGCTGATACCTGCTCTAGTGAG
TTGTGCTATTCCTGTCACATCCTTGCAGAGGTCCAAGGGTTGCTGGCAAGTGAAGGAATATCATGCCTGTAGTTTGAAGGATAGATCACT
CAACTCTCAACTATTCTCTCTTCAGCTGTGAACCATACAACGTTTTTGAAAAGCAAAGTCTGAACATTTGCATTCTATACAGAATATTAC
AGTTGGAAAATAGGTGTGGTGTCTAGAGAAATGCTTCTAAATGCTGCAAGCCACCCTATGTGAAGCCTAGTCTAGAAATCTGCTTTGCTT
CATTTATTAACTTCATTGTATCTTTGGAAGTAGAAGTTCTTAAAAGTGTGTACAGAAGATGAGTCCTCAGCATGAGTTTCACTGCCTGTC
TGTGTGAGAGGAAGTGACCTTGAGAGCAGCTGTAGCCCTAGGGGGACACCCAGGTAGAGGTGCTCACAACATGCTCTGACACCCGGTATG
GCTGCATTCCCAGCTTAAATGATCACATCTGCTCTTGGTTTTTTCACTGTTTACAAAATCTGATTTCTTTAAAGGGAAGGGATGGAAAAG
GTAGTCAATGCTCCTCTGAGCACCCAAAGCATCCCTCCACAAGAACAAAGAGGAAAAATCATTACTTGCTCCCAACATTACACAAAGCGC
ATCTCTACCAATGGAACTCTGCAGTGTCGGTCTAGCCATCAGCCTTTCCCACCTCACAGCATATTTTCTGTGGGGGTAATTTATTAGAGG
GGAATTTGTTCCTTTTTACTCTTTTTACTCTTCAAATTAGTAATAGAACCCCTCATGTCATTCTAAGTGACTTAAGTTTTAAAGGGAACC
AGAAAAGGAGAGAATATGCTATTGTGGCACTTCTAAAATGCAGAGTGTCCTCAAAGATGGTTATAGTGGGTAATGGGTTTCATATAAATT
GCATACTAGAGTATCTCCATTTCCTCTTTTAATTTTTTAATTGGTTTTTTAAAGCTTGATATGCTGAGTTAGTTTTCATTTAAAAACAAT
GCTTGAGTAGGAAAGTTAAAGAAATAGAAATTGCCTGTTTTAATCTATTCATCCTGGCAGCAGGTATGTATTGTATCTGTCCAGAGTCCA
AAACGTCAGCTCCCTCCACTTGCCTTCCCCATTTCACATAAACTATAAAAGTTAGAAATAATATATTATGTCATATCCTAACATCAGTTC
AATGAATATAGTTTTTAAAATACCTACTATGTGCTAGATACTGAGGACAGAATGATAAAATACAAAACAAAGCTAACTAAAAACACAGTT
TAACTAGTCTTGTCTACGATTACCTGCCCTAACTATAACTTCATTTAAGGGGAGATACTGCTAAAGGGAGTTCCTTCTGTGACTGCACAC
TCTGATACCAATATGTGACTTCTCCCTGGCTACAACTGATTAAATGAGGGAAGAAAACTGATCCAAGGGGAGTTAGTCCAATAGCTTGTA
AATGGTGGGTTCTTATCAGAGTTTTCTCACTAAGTTAGAACCAAGAGGCTGAGGGTTGTGGGGGCTACTTAAGCAGAAAGTTTCATGGAG
TATGGACTGTGCACCATTGTGAAGTTTCCTGTATTTCCACAGGCTGTGGGGGCAGAGAGCATCAGAGTGCTGATCAGGAAAAAAGAATGA
GGCAGATGCAGACAGAGAAGCAAAGAAGCATGAGAGGATGAGAATTAGGAAGTAGACTCTTTTTTCATTTTAATTAATTTGACTAGATTA
TATTTCTTGCAATCAAAAGGGCCCTGTGCAGAGAAGGTCCTTATCTTCGTTCATTTTTTGTTGCTATAGCTGAATACCCGAGACTGGGTA
ATTTATAAAGTAAAGAAATTTATTGCTTACCATTTTAGATGCTGGGAAGTACAAGGTCAAGGGTTCTCATCTAGTGAGGGCCTTCTTGCT
AGTGGGGTCTCTGTAGAGTCCTGAGGTAACACAGAGCATCACATGGTGTGGGGGTGGGATTCACCAGAGAGAGCCAAACTGACTTTTATA
ACAGACTCACTTTTGTGGTAACTAACCCACTCCCTTGATAGCCCATCAATCCATTAATCTAGAAATAAATTCATTCACTCATGAGGGCAG
AGCTCTTGTGAACCAATCACCTCCCAGAAGTCCCACCTCTCAACACTGCTGCACTGGGGACCAAATTTCCAACACATGAACTTTTCGGGG
ACACATTCAAGCCACAACAGTCCTCAATAAATATTTGTTGAATCAATAAATACACAGGACATAGTGTCCTAAATGCTTGGCATGTACATG
AACCAGATTTGGTCCTTGATGTCACAGAGCTTATAATATAGTGGAGGAGACAGACTTTACATGTTTGATCTTGACTGTAAAACTAGGGTC
ACTACTCATCATCTGATGAAGGAGGCAGACAGTAAAACAAATAACAACTATTCAACATGGTAACGTCAAAACTGAACAGAGGCTCAAGTG
AAAGTTTCAATGATAGTAACCATGGCCAATGGATAGGTGAATGCATTGGAAAATTAGTATGATGCCATTAGCAAAAACATAAATTGCACT
TAACTAAAGTTCATCTGGCTGAATTCTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTTCTTCCTCTATCTTTCTTTGGTTTT
GAGATCTGTCTATAGTATTGTGCTAGTGCACATATTTTAATTTGGTGCAAGGCATGCTTAACAGAGTAAGTGAAAAGCTATAAAGGTTAG
AGCGTGTATTAGTTTCAATGACGAAGGAGTAATAAATCATTTTGTCAGGTTGCACTCTAACATTCAAATTCCATTTTTATTATGGCTAAC
TAGCCAAGCATTTATAATTCTGAACTCCACAGAATGGGGAAAAAGTGTATTAACTTATAATAGATCATTGAGCTTGTTAAATGTACCTTT
CCTAATTCGTACTTTTTCCCTTTTGCTGAGAAAAATGCCTTTCTGAATATATAATTTTTACAGGTCATTGGAAAGGAGTACTGCACAACA
GGATTATTATAATGTGCTAAAAGATGGCACTTGTATCTCATTGCCACATAGAGAGCTCATGTGAAAACTCTTTGATCTTTGCTGGCTTTT
TAGCTGAAAAGATTTGGAAATCTTTTTGGCACTGGCAAAAACAGAACTGTGGTAACTGTTTATAGTTGGTTGATTTTTAGCAATGGGTAA
GAATGTCTTTGTTGAATCCAGTTTATTAATACGTAATGGGCAACATGTTGCCTTAAAGGCAAAAGCATATTTTTCTCATATCAAAAAGCT
CCCTAAATTTTTGCCAATATCCAAAGATATTTTAAGATGGTCTTCATTTTCTTTTTCAGTCTGTCCTATGCTGAGAAAAAAAAATTACAA
CCTCTGAACTTCAGCAGTTTTTTAGGTAAAAGGAATTTTTCATGATGTGATTGATATAACTACTCAGCTGGACATAAGCTTTCAAGGGCT
AAGTCCATTTGCCGATTTGTTTGCATTTCCTACTCCAACTAAAATAATTCAAAGACATGAAGTGTCTATTGTGGAAAATGCATGAATAAT
GCAAAAGTCATTCTCAAGTGACCTATCAGAAAGGCCTACCAGAAATGCAGTTACTGCTTTCTAATAAAATCATGAAAAACTTTTTTAAAA
AGTATAACCATCTTGAATTTGTTGAGGCAATTATAAGAGAGTATATAAGGGCAAGTTTCTCCAAAAGCGGTTCTGTTTGTTTTGTTTTTT
TTTAATAATTCCCATCAACAGCAATCTGTTTTCTCATTGTAGTAGTATAGGTGTTAACATAAAAGCTCAAACAGCTTGGGAGAAAAAAAA
GGATATAGCAAACCTAACTGATAACTTTGCTAGTTTCAAATCATTATGATGGCCATTCATAGATGACTGAAATATTTAACATTTGAAGTA
ACAGAATTTTGACTTATGTTTTCATGGTTTAAGAGTTTATATTTCAAATTTTTTCACATAGTCTGTTTATAACAGTATATAAAACATGTA
TTAACTATATAAGTTAATAAAGTCATGAACTGATGGCCATTTTTTGGTCTTATTCATATAGTATAGGCTGTTTTGTGAATTAATCCCCTT
CCCATGTGTTTGAATTCCCCACTATGTAAGGCTTAGTGGTGTTAGCATGATCCAAGGGTGGGATTTTCAGCCCTCTGACATCAAAAGGTG
AAGCAGAGGACACAAAAACCCTCACTGCATCTTCCCTAGACTGGCCAGAACCACTCCATGGTCAGTGGACTCCCTTAATAGGAAGGAATG
CTGGTCAGTTGTCAAAGAGCAAAAAGGGAGGGGTAGTCATGAGGTTGGTTGTAATCAGAGGTGCAACAGGTCTTTCCAAAGGGCTGGTTT
CTGTTTAACTCTTAGGAAAGAACACCTAATGGTAGTTAGTGAGGAGGGGGTATAATGAGATGTGCCCAACCTCCCATCCCATCATGGCCG
GGAACTCAGTTTTTAAGGTTTCCCTGAAGTCCTCTTGGCCAGGAGAGGGTCTGTTTAGTCAAATGTGGGGGGGGAGCTTAGGATTTTATT
TTTATTTCCAAGTTATAATGTTGGACCATCAGAGCATGAATACAGGTTGAGTCTTTAATCTGTAAATACTTAGCAATCACCTTCTTCTCA
GTAACTTTCTCTGAAGGTTGCTGATAAGCCAGTGTTCTTGATGTTTGCCCACTTACCCCTCAAGATGAGGAGTGAAGAAATTAGATTGCA
TTGCCAGGAATTTCCTAGAAGAAAAGGTTTTGAGGATGCATGACCTATGAGGGTGCTGAGGACCCCTTTCCACCAAACATGGACTAACTT
CTGGGTTGCTCTTTCACATCTATTGTCTTGTTCGACGTACACAGAAGTGCAGAGCACAGCCGCAGCCCTCACAGCATCATCTATCTAGGT
TCTGAATCCTGAATGGTCTGAGGCTCTCCTAGAGCTGAGATTCTCCTTTGCAGTTCCAGTGGAGAAAAGCACTTTCTTTGCCGAGGCAGT
GTAACTTCCTTGTTCCCAAGGCTCCAACTGTTGTGGGCACATATGAGTATACATTAACATCCATGCCCAATTTATAATCACTGTTTTCCC
CACATGTGTACTCAGACCTCCAAGCTTCTGAAAAATATTTCCTCTCATCTCTCAAAGAATTTTAGTACATTTGCCTGGATGCAGAAACAC
AAATCATGCTGGCTTTCCTACTCAATCAAAAACTGTAGCTTGAGTGGGGTGGCAAGGGTTGTCCCACAGCAGGTTTACTTGGACTCCAAA
ATGATGTAGAGTTTAGTGAGGCAGCTCCTTGAGTTTGAACTTAGAGCCCTTTTGGCTACCAGGGCACCTGCAGTCCTCCAAGATAGTAGA
GTCTGAACCAGTTAAAGAGCCAGCTACCACAGCTTTGCAGAAACCACTGTTTCTCCTTAACTCTAGGGCTCAGCGGTTGAACTCCTTAGA
ATAAAACTTTCTGTCTGCGACCCTATCATTTTCTTTTGTATTTTGGCCTTCACTGAATTCCCACCCCATCCATTCCAACAGACTTGGTTA
TACGTGTCTGAACACCAAATGTGACAGAATTTGTGGCCTTGGATCAGGAGGCTATTTGGCCCTTATCTAAATCGGTGGCTGAGAATGGAT
TCCAGGGAAGTGTTTTTCTTAGGAGTACCCAAGAAGCTCAGCTCAGGTTGGGCTCCCTGTTCTATTCTGAGAACTACAAATCAAATTCAA
AATGGAGCACAGAAAATTCTCATTTCTAGTTGACTTATTTGTATTTTGGTGTCCTGTGCCCTAAATATCTTCTCAAGGAAACCTTGGCTT
TAAAAGTGATTGTTTACTTAAACAAATAAAACAACAACATACAAGAAAAGGCAGTAAATCCGAGCGTCCATCAACAAATGAATCAAAAAA
CAAATGAGATATATATGTACGGTGGCATATTATTCAGCCTTAAAAAGGAAAGAAATTTTGACACATGAGACAATATGAATGAACCTTGAA
GACATTAATTATGCTGAGTGAAATAAGCCAGCCACAAAAGAACAGATATTGTATAATTCCTCTTATATTAGGTACCTAAAATAGTCAAAT
TGATAGAAAGTAGAATGTTGGTTGGCAGGGGCTGGCAAGGAGAGGGAAATGAAGAGAAGGTGTATGAAGGGAACAGAGTTTCAGTTGGGG
AAGACGAAAAAGTTCTGACAGTGGATGATGGTGGTTGTTGCACAGCAACATGAATGTACTTAATGCCACAGAACTGTATGCTTAAAAATG
GTTGAAACGGTAAATTTGATATAATGTGTATTGAACCTATTTCCAGATCAAAACAGAGAGATCTACATTCCTTTTGGTGGTGTCAAAATA

>100539_100539_2_ZC3H15-NCKAP1_ZC3H15_chr2_187360061_ENST00000337859_NCKAP1_chr2_183888644_ENST00000361354_length(amino acids)=1151AA_BP=59
MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQACGDPKAKPSYLIDKNLESAVKFIVRKFPAV
ETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAII
GLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDT
MPCEYLSLDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGS
MHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQ
RYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMN
TIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMA
KQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVV
WEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSL
YTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVL
TQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGL
PCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKE

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Fusion Gene PPI Analysis for ZC3H15-NCKAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZC3H15-NCKAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZC3H15-NCKAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource