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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZC3H3-SCRIB (FusionGDB2 ID:100561)

Fusion Gene Summary for ZC3H3-SCRIB

Fusion gene summary

Fusion gene information	Fusion gene name: ZC3H3-SCRIB
	Fusion gene ID: 100561
		Hgene	Tgene
	Gene symbol	ZC3H3	SCRIB
	Gene ID	23144	23513
	Gene name	zinc finger CCCH-type containing 3	scribble planar cell polarity protein
	Synonyms	SMICL\|ZC3HDC3	CRIB1\|SCRB1\|SCRIB1\|Vartul
	Cytomap	8q24.3	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	zinc finger CCCH domain-containing protein 3smad-interacting CPSF-like factorzinc finger CCCH-type domain containing 3	protein scribble homologscribbled homologscribbled planar cell polarity protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262577,	ENST00000546337, ENST00000320476, ENST00000356994, ENST00000377533,
Fusion gene scores	* DoF score	14 X 8 X 9=1008	3 X 3 X 3=27
	# samples	17	3
	** MAII score	log2(17/1008*10)=-2.56788898736222 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ZC3H3 [Title/Abstract] AND SCRIB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZC3H3(144547887)-SCRIB(144889183), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SCRIB	GO:0008283	cell proliferation	16965391
Tgene	SCRIB	GO:0045930	negative regulation of mitotic cell cycle	16965391

Fusion gene breakpoints across ZC3H3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCRIB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8580-01A	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-

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Fusion Gene ORF analysis for ZC3H3-SCRIB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262577	ENST00000546337	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-
In-frame	ENST00000262577	ENST00000320476	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-
In-frame	ENST00000262577	ENST00000356994	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-
In-frame	ENST00000262577	ENST00000377533	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262577	ZC3H3	chr8	144547887	-	ENST00000320476	SCRIB	chr8	144889183	-	5297	2339	32	5053	1673
ENST00000262577	ZC3H3	chr8	144547887	-	ENST00000356994	SCRIB	chr8	144889183	-	5372	2339	32	5128	1698
ENST00000262577	ZC3H3	chr8	144547887	-	ENST00000377533	SCRIB	chr8	144889183	-	5291	2339	32	5053	1673

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262577	ENST00000320476	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-	0.010456181	0.9895438
ENST00000262577	ENST00000356994	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-	0.013256623	0.98674333
ENST00000262577	ENST00000377533	ZC3H3	chr8	144547887	-	SCRIB	chr8	144889183	-	0.010599993	0.98939997

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Fusion Genomic Features for ZC3H3-SCRIB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZC3H3-SCRIB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:144547887/chr8:144889183)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZC3H3

chr8:144547887

chr8:144889183

ENST00000262577

382_391

769

949.0

Compositional bias

Note=Poly-Ser

Hgene

ZC3H3

chr8:144547887

chr8:144889183

ENST00000262577

667_695

769

949.0

Zinc finger

C3H1-type 1

Hgene

ZC3H3

chr8:144547887

chr8:144889183

ENST00000262577

699_722

769

949.0

Zinc finger

C3H1-type 2

Hgene

ZC3H3

chr8:144547887

chr8:144889183

ENST00000262577

723_749

769

949.0

Zinc finger

C3H1-type 3

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

1379_1419

726

1631.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

1379_1419

726

1656.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

1379_1419

645

1550.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

656_701

645

1550.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

1296_1349

726

1631.0

Compositional bias

Note=Pro-rich

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

1296_1349

726

1656.0

Compositional bias

Note=Pro-rich

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

1296_1349

645

1550.0

Compositional bias

Note=Pro-rich

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

660_695

645

1550.0

Compositional bias

Note=Glu-rich

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

1004_1093

726

1631.0

Domain

PDZ 3

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

1100_1194

726

1631.0

Domain

PDZ 4

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

728_815

726

1631.0

Domain

PDZ 1

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

862_950

726

1631.0

Domain

PDZ 2

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

1004_1093

726

1656.0

Domain

PDZ 3

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

1100_1194

726

1656.0

Domain

PDZ 4

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

728_815

726

1656.0

Domain

PDZ 1

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

862_950

726

1656.0

Domain

PDZ 2

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

1004_1093

645

1550.0

Domain

PDZ 3

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

1100_1194

645

1550.0

Domain

PDZ 4

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

728_815

645

1550.0

Domain

PDZ 1

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

862_950

645

1550.0

Domain

PDZ 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZC3H3

chr8:144547887

chr8:144889183

ENST00000262577

873_881

769

949.0

Compositional bias

Note=Poly-Ser

Hgene

ZC3H3

chr8:144547887

chr8:144889183

ENST00000262577

750_777

769

949.0

Zinc finger

C3H1-type 4

Hgene

ZC3H3

chr8:144547887

chr8:144889183

ENST00000262577

778_800

769

949.0

Zinc finger

C3H1-type 5

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

458_474

726

1631.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

656_701

726

1631.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

458_474

726

1656.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

656_701

726

1656.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

458_474

645

1550.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

660_695

726

1631.0

Compositional bias

Note=Glu-rich

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

660_695

726

1656.0

Compositional bias

Note=Glu-rich

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

1_818

726

1631.0

Region

Note=Sufficient for targeting to adherens junction and to inhibit cell proliferation

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

1_818

726

1656.0

Region

Note=Sufficient for targeting to adherens junction and to inhibit cell proliferation

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

1_818

645

1550.0

Region

Note=Sufficient for targeting to adherens junction and to inhibit cell proliferation

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

106_127

726

1631.0

Repeat

Note=LRR 4

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

129_150

726

1631.0

Repeat

Note=LRR 5

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

152_174

726

1631.0

Repeat

Note=LRR 6

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

175_197

726

1631.0

Repeat

Note=LRR 7

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

198_219

726

1631.0

Repeat

Note=LRR 8

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

221_243

726

1631.0

Repeat

Note=LRR 9

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

244_265

726

1631.0

Repeat

Note=LRR 10

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

267_288

726

1631.0

Repeat

Note=LRR 11

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

290_312

726

1631.0

Repeat

Note=LRR 12

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

313_334

726

1631.0

Repeat

Note=LRR 13

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

336_357

726

1631.0

Repeat

Note=LRR 14

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

359_381

726

1631.0

Repeat

Note=LRR 15

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

37_58

726

1631.0

Repeat

Note=LRR 1

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

382_402

726

1631.0

Repeat

Note=LRR 16

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

60_81

726

1631.0

Repeat

Note=LRR 2

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000320476

83_104

726

1631.0

Repeat

Note=LRR 3

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

106_127

726

1656.0

Repeat

Note=LRR 4

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

129_150

726

1656.0

Repeat

Note=LRR 5

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

152_174

726

1656.0

Repeat

Note=LRR 6

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

175_197

726

1656.0

Repeat

Note=LRR 7

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

198_219

726

1656.0

Repeat

Note=LRR 8

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

221_243

726

1656.0

Repeat

Note=LRR 9

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

244_265

726

1656.0

Repeat

Note=LRR 10

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

267_288

726

1656.0

Repeat

Note=LRR 11

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

290_312

726

1656.0

Repeat

Note=LRR 12

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

313_334

726

1656.0

Repeat

Note=LRR 13

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

336_357

726

1656.0

Repeat

Note=LRR 14

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

359_381

726

1656.0

Repeat

Note=LRR 15

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

37_58

726

1656.0

Repeat

Note=LRR 1

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

382_402

726

1656.0

Repeat

Note=LRR 16

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

60_81

726

1656.0

Repeat

Note=LRR 2

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000356994

83_104

726

1656.0

Repeat

Note=LRR 3

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

106_127

645

1550.0

Repeat

Note=LRR 4

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

129_150

645

1550.0

Repeat

Note=LRR 5

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

152_174

645

1550.0

Repeat

Note=LRR 6

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

175_197

645

1550.0

Repeat

Note=LRR 7

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

198_219

645

1550.0

Repeat

Note=LRR 8

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

221_243

645

1550.0

Repeat

Note=LRR 9

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

244_265

645

1550.0

Repeat

Note=LRR 10

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

267_288

645

1550.0

Repeat

Note=LRR 11

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

290_312

645

1550.0

Repeat

Note=LRR 12

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

313_334

645

1550.0

Repeat

Note=LRR 13

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

336_357

645

1550.0

Repeat

Note=LRR 14

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

359_381

645

1550.0

Repeat

Note=LRR 15

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

37_58

645

1550.0

Repeat

Note=LRR 1

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

382_402

645

1550.0

Repeat

Note=LRR 16

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

60_81

645

1550.0

Repeat

Note=LRR 2

Tgene

SCRIB

chr8:144547887

chr8:144889183

ENST00000377533

83_104

645

1550.0

Repeat

Note=LRR 3

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Fusion Gene Sequence for ZC3H3-SCRIB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>100561_100561_1_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000320476_length(transcript)=5297nt_BP=2339nt
GGGGGCCTGGCCGGCCGTCGCGGACTCGGGAGATGGAGGAAAAGGAGATATTACGGCGGCAGATCCGCCTACTGCAGGGTCTGATTGATG
ACTACAAAACCCTCCACGGCAATGCCCCGGCCCCTGGTACCCCAGCAGCTTCTGGGTGGCAGCCACCCACTTACCACAGTGGCAGAGCCT
TTAGTGCCCGCTACCCTCGTCCAAGCCGGAGGGGCTACTCTTCCCACCATGGGCCTTCGTGGCGCAAGAAATACTCCCTCGTGAATCGGC
CCCCGGGACCCTCAGACCCTCCTGCCGACCATGCTGTGCGGCCGTTGCACGGGGCCCGGGGGGGCCAGCCTCCTGTCCCGCAGCAGCATG
TCCTTGAGAGACAGGTCCAGCTCAGTCAGGGTCAGAACGTGGTCATCAAAGTTAAACCGCCATCAAAGTCTGGCTCTGCCAGTGCCTCAG
GGGCCCAGCGGGGCTCTTTGGAAGAATTTGAGGAAACCCCCTGGAGTGACCAAAGGCCCCGGGAAGGTGAAGGTGAGCCCCCTCGGGGAC
AGCTGCAGCCCTCGAGGCCAACAAGAGCCAGGGGGACCTGCAGTGTGGAAGATCCTCTTCTGGTCTGCCAGAAGGAGCCTGGTAAGCCCA
GGATGGTGAAGTCAGTGGGCAGTGTGGGCGACAGCCCCCGGGAGCCCCGCCGGACAGTCAGTGAGAGTGTGATTGCCGTCAAGGCGAGCT
TCCCATCCTCCGCTCTGCCCCCACGCACTGGCGTGGCCCTGGGCCGGAAGCTGGGTTCTCATTCCGTGGCCAGCTGTGCTCCACAGCTCC
TTGGGGACAGGAGAGTAGATGCTGGCCACACAGATCAGCCAGTTCCGTCTGGCTCAGTGGGGGGCCCCGCCAGACCGGCCTCAGGACCCA
GGCAGGCCCGGGAGGCCTCGCTGGTTGTGACCTGTCGAACTAACAAGTTCCGGAAAAACAACTACAAATGGGTGGCTGCCTCCTCGAAGA
GTCCCCGGGTTGCTCGGAGGGCCCTCAGTCCCAGAGTGGCTGCAGAGAATGTGTGCAAGGCCTCTGCTGGCATGGCAAACAAGGTGGAGA
AGCCGCAGCTCATAGCTGACCCAGAGCCCAAGCCCAGGAAGCCAGCCACGTCCTCCAAGCCAGGGTCTGCCCCCAGCAAGTACAAGTGGA
AGGCCTCCAGCCCCTCTGCCTCCTCCTCTTCCTCCTTCCGTTGGCAGTCGGAGGCCAGCAGCAAGGACCATGCCTCCCAGCTCTCCCCAG
TCCTGTCTAGGTCCCCGTCGGGGGACAGACCAGCAGTAGGACACAGTGGCTTGAAGCCCCTCTCTGGGGAGACCCCGCTCTCGGCTTACA
AAGTGAAGAGCCGCACCAAGATCATCCGGAGACGCAGCAGCACAAGCCTTCCTGGAGACAAGAAAAGCGGCACCTCACCTGCCGCCACCG
CCAAGAGCCACCTCAGCCTCCGGCGGAGACAGGCCCTCAGGGGGAAGAGCAGCCCTGTCCTGAAGAAGACCCCCAACAAGGGCCTGGTAC
AGGTCACCACGCACCGACTATGTCGCCTGCCACCGAGCCGGGCCCACCTCCCCACCAAGGAAGCGTCCAGCCTGCATGCCGTGCGGACTG
CACCCACCAGCAAGGTGATCAAGACCCGCTACCGCATTGTCAAGAAGACGCCGGCCTCGCCTCTCAGCGCCCCGCCCTTCCCCCTGTCTC
TGCCCTCCTGGCGGGCCCGGCGGCTCTCACTATCCAGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTGCCAGCGGGGGTGGGAAAGCCC
AACCGGGCTCCCCTTGGTGGCGGAGCAAAGGCTACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTGCCAACAAGCTCTCCAAGACCT
CCGGCCAGCCCAGTGATGCGGGCAGCAGGCCCCTCCTGCGCACAGGCCGGCTGGATCCTGCAGGCAGCTGTAGCCGTTCCCTGGCCAGCC
GGGCAGTGCAGCGCAGCCTGGCCATCATCCGGCAGGCGCGGCAGCGCAGGGAGAAGAGGAAGGAGTACTGCATGTACTACAACCGCTTCG
GCAGGTGCAACCGTGGCGAGCGCTGCCCCTACATCCACGATCCCGAGAAGGTGGCCGTGTGCACCAGGTTTGTCCGGGGCACCTGCAAGA
AAACGGATGGGACCTGCCCCTTCTCCCACCATGTGTCCAAGGAGAAGATGCCGGTGTGCTCCTACTTCCTGAAGGGCATCTGCAGCAACA
GCAACTGTCCCTATAGCCACGTGTACGTGTCCCGCAAGGCCGAGGTCTGCAGCGACTTCCTCAAAGGCTACTGCCCCCTGGGTGCAAAGC
TGACCCTCACTATCCTGCGGCAGACTGGGGGCCTGGGCATCAGCATTGCGGGCGGCAAGGGCTCCACACCCTATAAGGGGGACGACGAGG
GCATATTCATCTCTCGGGTGTCCGAGGAAGGCCCTGCGGCCCGGGCTGGAGTCCGTGTGGGTGACAAGCTCCTGGAGGTGAATGGTGTGG
CTCTGCAGGGCGCCGAGCACCACGAGGCCGTGGAGGCGCTCCGGGGGGCCGGCACTGCCGTGCAGATGCGAGTGTGGCGGGAGCGCATGG
TGGAGCCTGAGAACGCGGTCACCATCACGCCGCTGCGGCCCGAGGATGATTACAGCCCCCGAGAGCGGCGGGGAGGGGGGCTGCGCCTGC
CCCTGCTCCCGCCTGAGAGCCCCGGGCCCCTCCGTCAGCGCCACGTGGCCTGCCTGGCACGCAGCGAGAGGGGGCTGGGCTTCAGCATTG
CTGGTGGGAAAGGCTCCACACCCTACAGGGCTGGTGATGCGGGCATCTTCGTCTCCCGCATTGCCGAGGGCGGTGCTGCTCACCGCGCGG
GCACACTGCAGGTTGGCGACCGCGTCCTCTCTATTAATGGAGTGGACGTGACTGAGGCCAGGCATGACCACGCCGTCTCCCTGCTGACCG
CTGCCTCCCCCACCATCGCCCTGCTGTTGGAGCGGGAGGCTGGGGGCCCTCTTCCTCCCAGCCCTCTGCCACATTCCTCACCCCCCACCG
CTGCTGTTGCCACCACCAGCATAACCACTGCCACCCCCGGGGTGCCTGGGTTGCCGAGCCTGGCCCCCAGCCTGCTGGCTGCCGCGTTGG
AAGGGCCATACCCAGTGGAGGAGATCCGTCTGCCAAGAGCTGGGGGCCCTCTGGGGCTTAGTATTGTCGGAGGCTCCGACCATTCCAGCC
ACCCGTTTGGTGTCCAGGAGCCTGGTGTGTTCATCTCCAAGGTGCTCCCGCGGGGCCTGGCCGCTCGCAGCGGCCTGCGGGTTGGGGACC
GCATCCTGGCAGTGAACGGGCAAGACGTGCGGGATGCCACGCACCAAGAAGCAGTCAGTGCCCTGCTCCGGCCCTGCCTGGAGCTGTCGC
TGCTGGTGCGGAGGGACCCGGCACCCCCGGGCCTACGGGAACTGTGCATCCAGAAGGCACCTGGGGAGAGGCTGGGCATCAGCATCCGCG
GGGGTGCCAGGGGCCACGCTGGCAACCCCCGCGACCCCACAGACGAGGGCATCTTCATCTCCAAGGTGAGCCCCACGGGGGCAGCCGGGC
GCGACGGTCGGCTGCGTGTGGGTTTGCGGCTGTTGGAGGTGAACCAGCAGAGCCTGCTGGGCCTGACGCACGGCGAGGCGGTGCAGCTGC
TCCGCAGTGTGGGCGACACCCTCACCGTGCTGGTCTGTGACGGCTTTGAGGCCAGCACCGACGCAGCCCTGGAGGTGTCCCCAGGTGTCA
TTGCCAACCCCTTTGCGGCAGGCATCGGCCACCGGAACAGCCTGGAGAGCATCTCTTCCATCGACCGGGAGCTGAGCCCTGAGGGCCCAG
GCAAGGAGAAGGAGCTGCCTGGACAGACCCTGCACTGGGGGCCCGAGGCCACAGAAGCCGCAGGTCGGGGTCTGCAGCCCCTGAAGCTGG
ACTACCGCGCCCTGGCCGCCGTGCCCAGCGCTGGCAGCGTGCAGAGGGTACCGTCTGGAGCAGCTGGAGGGAAGATGGCTGAATCTCCCT
GCTCCCCTAGTGGCCAGCAGCCGCCCTCCCCGCCTTCTCCGGATGAGCTGCCCGCCAATGTGAAGCAGGCCTACAGGGCCTTCGCGGCCG
TGCCCACTTCTCACCCGCCTGAGGATGCCCCTGCCCAGCCCCCCACGCCTGGGCCTGCAGCCTCCCCGGAGCAGCTGTCCTTCCGGGAGC
GGCAGAAGTACTTTGAGCTGGAGGTGCGCGTGCCCCAGGCCGAGGGCCCCCCTAAGCGCGTGTCCCTGGTGGGTGCTGACGACCTGCGGA
AGATGCAGGAGGAGGAAGCCAGAAAACTACAGCAGAAGAGAGCGCAGATGCTGCGGGAGGCGGCAGAGGCTGGGGCCGAAGCGAGGCTCG
CCCTGGACGGGGAGACGCTGGGCGAGGAGGAACAGGAGGATGAGCAGCCACCCTGGGCCAGCCCGAGCCCCACCTCAAGGCAGAGCCCGG
CGTCCCCCCCACCCCTGGGAGGTGGCGCCCCGGTGCGGACGGCCAAAGCTGAACGGCGCCACCAGGAGCGGCTGCGCGTGCAGAGTCCGG
AGCCACCGGCACCCGAGCGTGCCCTGTCCCCTGCCGAGCTCCGGGCCCTGGAGGCCGAGAAGCGTGCGCTGTGGAGGGCAGCCAGGATGA
AGTCATTGGAACAGGACGCTCTCCGAGCACAGATGGTCCTCAGCAGGTCCCAGGAAGGCCGGGGCACGCGGGGGCCCCTGGAGCGACTGG
CCGAGGCCCCTTCCCCTGCGCCCACCCCGTCGCCCACCCCTGTGGAAGACCTCGGCCCCCAGACCAGCACCTCCCCGGGACGCCTGTCAC
CGGACTTTGCTGAGGAGTTGAGGTCCCTGGAACCATCTCCCAGCCCTGGCCCGCAGGAGGAGGATGGAGAAGTGGCTCTGGTGCTTCTGG
GCAGGCCCTCACCCGGCGCTGTGGGCCCTGAAGATGTGGCACTGTGCAGCAGCCGCCGCCCCGTAAGGCCTGGGCGCCGTGGCCTGGGCC
CTGTGCCCTCCTAGAGGAGCAGGCACCTCCCCCAGACTTGGGGTGGGGGCCCTGCCAGCTCCAGCACCACCCTTGCCCCAAGTCTTTTAA
CCTGGGTGTTAGCATTTTAAAGAGACCCCACAGGAGTTCTGGCCTGTGACTAACTAACTGCCCCACCCCAGCCGAGACCTCGGCGAGACT

>100561_100561_1_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000320476_length(amino acids)=1673AA_BP=769
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADH
AVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHT
DQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR
RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRP
LLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKLTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG
PAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPL
RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE
REAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVF
ISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR
DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGH
RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSP
PSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQ
QKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSP
AELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLSPDFAEELRSLE

--------------------------------------------------------------
>100561_100561_2_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000356994_length(transcript)=5372nt_BP=2339nt
GGGGGCCTGGCCGGCCGTCGCGGACTCGGGAGATGGAGGAAAAGGAGATATTACGGCGGCAGATCCGCCTACTGCAGGGTCTGATTGATG
ACTACAAAACCCTCCACGGCAATGCCCCGGCCCCTGGTACCCCAGCAGCTTCTGGGTGGCAGCCACCCACTTACCACAGTGGCAGAGCCT
TTAGTGCCCGCTACCCTCGTCCAAGCCGGAGGGGCTACTCTTCCCACCATGGGCCTTCGTGGCGCAAGAAATACTCCCTCGTGAATCGGC
CCCCGGGACCCTCAGACCCTCCTGCCGACCATGCTGTGCGGCCGTTGCACGGGGCCCGGGGGGGCCAGCCTCCTGTCCCGCAGCAGCATG
TCCTTGAGAGACAGGTCCAGCTCAGTCAGGGTCAGAACGTGGTCATCAAAGTTAAACCGCCATCAAAGTCTGGCTCTGCCAGTGCCTCAG
GGGCCCAGCGGGGCTCTTTGGAAGAATTTGAGGAAACCCCCTGGAGTGACCAAAGGCCCCGGGAAGGTGAAGGTGAGCCCCCTCGGGGAC
AGCTGCAGCCCTCGAGGCCAACAAGAGCCAGGGGGACCTGCAGTGTGGAAGATCCTCTTCTGGTCTGCCAGAAGGAGCCTGGTAAGCCCA
GGATGGTGAAGTCAGTGGGCAGTGTGGGCGACAGCCCCCGGGAGCCCCGCCGGACAGTCAGTGAGAGTGTGATTGCCGTCAAGGCGAGCT
TCCCATCCTCCGCTCTGCCCCCACGCACTGGCGTGGCCCTGGGCCGGAAGCTGGGTTCTCATTCCGTGGCCAGCTGTGCTCCACAGCTCC
TTGGGGACAGGAGAGTAGATGCTGGCCACACAGATCAGCCAGTTCCGTCTGGCTCAGTGGGGGGCCCCGCCAGACCGGCCTCAGGACCCA
GGCAGGCCCGGGAGGCCTCGCTGGTTGTGACCTGTCGAACTAACAAGTTCCGGAAAAACAACTACAAATGGGTGGCTGCCTCCTCGAAGA
GTCCCCGGGTTGCTCGGAGGGCCCTCAGTCCCAGAGTGGCTGCAGAGAATGTGTGCAAGGCCTCTGCTGGCATGGCAAACAAGGTGGAGA
AGCCGCAGCTCATAGCTGACCCAGAGCCCAAGCCCAGGAAGCCAGCCACGTCCTCCAAGCCAGGGTCTGCCCCCAGCAAGTACAAGTGGA
AGGCCTCCAGCCCCTCTGCCTCCTCCTCTTCCTCCTTCCGTTGGCAGTCGGAGGCCAGCAGCAAGGACCATGCCTCCCAGCTCTCCCCAG
TCCTGTCTAGGTCCCCGTCGGGGGACAGACCAGCAGTAGGACACAGTGGCTTGAAGCCCCTCTCTGGGGAGACCCCGCTCTCGGCTTACA
AAGTGAAGAGCCGCACCAAGATCATCCGGAGACGCAGCAGCACAAGCCTTCCTGGAGACAAGAAAAGCGGCACCTCACCTGCCGCCACCG
CCAAGAGCCACCTCAGCCTCCGGCGGAGACAGGCCCTCAGGGGGAAGAGCAGCCCTGTCCTGAAGAAGACCCCCAACAAGGGCCTGGTAC
AGGTCACCACGCACCGACTATGTCGCCTGCCACCGAGCCGGGCCCACCTCCCCACCAAGGAAGCGTCCAGCCTGCATGCCGTGCGGACTG
CACCCACCAGCAAGGTGATCAAGACCCGCTACCGCATTGTCAAGAAGACGCCGGCCTCGCCTCTCAGCGCCCCGCCCTTCCCCCTGTCTC
TGCCCTCCTGGCGGGCCCGGCGGCTCTCACTATCCAGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTGCCAGCGGGGGTGGGAAAGCCC
AACCGGGCTCCCCTTGGTGGCGGAGCAAAGGCTACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTGCCAACAAGCTCTCCAAGACCT
CCGGCCAGCCCAGTGATGCGGGCAGCAGGCCCCTCCTGCGCACAGGCCGGCTGGATCCTGCAGGCAGCTGTAGCCGTTCCCTGGCCAGCC
GGGCAGTGCAGCGCAGCCTGGCCATCATCCGGCAGGCGCGGCAGCGCAGGGAGAAGAGGAAGGAGTACTGCATGTACTACAACCGCTTCG
GCAGGTGCAACCGTGGCGAGCGCTGCCCCTACATCCACGATCCCGAGAAGGTGGCCGTGTGCACCAGGTTTGTCCGGGGCACCTGCAAGA
AAACGGATGGGACCTGCCCCTTCTCCCACCATGTGTCCAAGGAGAAGATGCCGGTGTGCTCCTACTTCCTGAAGGGCATCTGCAGCAACA
GCAACTGTCCCTATAGCCACGTGTACGTGTCCCGCAAGGCCGAGGTCTGCAGCGACTTCCTCAAAGGCTACTGCCCCCTGGGTGCAAAGC
TGACCCTCACTATCCTGCGGCAGACTGGGGGCCTGGGCATCAGCATTGCGGGCGGCAAGGGCTCCACACCCTATAAGGGGGACGACGAGG
GCATATTCATCTCTCGGGTGTCCGAGGAAGGCCCTGCGGCCCGGGCTGGAGTCCGTGTGGGTGACAAGCTCCTGGAGGTGAATGGTGTGG
CTCTGCAGGGCGCCGAGCACCACGAGGCCGTGGAGGCGCTCCGGGGGGCCGGCACTGCCGTGCAGATGCGAGTGTGGCGGGAGCGCATGG
TGGAGCCTGAGAACGCGGTCACCATCACGCCGCTGCGGCCCGAGGATGATTACAGCCCCCGAGAGCGGCGGGGAGGGGGGCTGCGCCTGC
CCCTGCTCCCGCCTGAGAGCCCCGGGCCCCTCCGTCAGCGCCACGTGGCCTGCCTGGCACGCAGCGAGAGGGGGCTGGGCTTCAGCATTG
CTGGTGGGAAAGGCTCCACACCCTACAGGGCTGGTGATGCGGGCATCTTCGTCTCCCGCATTGCCGAGGGCGGTGCTGCTCACCGCGCGG
GCACACTGCAGGTTGGCGACCGCGTCCTCTCTATTAATGGAGTGGACGTGACTGAGGCCAGGCATGACCACGCCGTCTCCCTGCTGACCG
CTGCCTCCCCCACCATCGCCCTGCTGTTGGAGCGGGAGGCTGGGGGCCCTCTTCCTCCCAGCCCTCTGCCACATTCCTCACCCCCCACCG
CTGCTGTTGCCACCACCAGCATAACCACTGCCACCCCCGGGGTGCCTGGGTTGCCGAGCCTGGCCCCCAGCCTGCTGGCTGCCGCGTTGG
AAGGGCCATACCCAGTGGAGGAGATCCGTCTGCCAAGAGCTGGGGGCCCTCTGGGGCTTAGTATTGTCGGAGGCTCCGACCATTCCAGCC
ACCCGTTTGGTGTCCAGGAGCCTGGTGTGTTCATCTCCAAGGTGCTCCCGCGGGGCCTGGCCGCTCGCAGCGGCCTGCGGGTTGGGGACC
GCATCCTGGCAGTGAACGGGCAAGACGTGCGGGATGCCACGCACCAAGAAGCAGTCAGTGCCCTGCTCCGGCCCTGCCTGGAGCTGTCGC
TGCTGGTGCGGAGGGACCCGGCACCCCCGGGCCTACGGGAACTGTGCATCCAGAAGGCACCTGGGGAGAGGCTGGGCATCAGCATCCGCG
GGGGTGCCAGGGGCCACGCTGGCAACCCCCGCGACCCCACAGACGAGGGCATCTTCATCTCCAAGGTGAGCCCCACGGGGGCAGCCGGGC
GCGACGGTCGGCTGCGTGTGGGTTTGCGGCTGTTGGAGGTGAACCAGCAGAGCCTGCTGGGCCTGACGCACGGCGAGGCGGTGCAGCTGC
TCCGCAGTGTGGGCGACACCCTCACCGTGCTGGTCTGTGACGGCTTTGAGGCCAGCACCGACGCAGCCCTGGAGGTGTCCCCAGGTGTCA
TTGCCAACCCCTTTGCGGCAGGCATCGGCCACCGGAACAGCCTGGAGAGCATCTCTTCCATCGACCGGGAGCTGAGCCCTGAGGGCCCAG
GCAAGGAGAAGGAGCTGCCTGGACAGACCCTGCACTGGGGGCCCGAGGCCACAGAAGCCGCAGGTCGGGGTCTGCAGCCCCTGAAGCTGG
ACTACCGCGCCCTGGCCGCCGTGCCCAGCGCTGGCAGCGTGCAGAGGGTACCGTCTGGAGCAGCTGGAGGGAAGATGGCTGAATCTCCCT
GCTCCCCTAGTGGCCAGCAGCCGCCCTCCCCGCCTTCTCCGGATGAGCTGCCCGCCAATGTGAAGCAGGCCTACAGGGCCTTCGCGGCCG
TGCCCACTTCTCACCCGCCTGAGGATGCCCCTGCCCAGCCCCCCACGCCTGGGCCTGCAGCCTCCCCGGAGCAGCTGTCCTTCCGGGAGC
GGCAGAAGTACTTTGAGCTGGAGGTGCGCGTGCCCCAGGCCGAGGGCCCCCCTAAGCGCGTGTCCCTGGTGGGTGCTGACGACCTGCGGA
AGATGCAGGAGGAGGAAGCCAGAAAACTACAGCAGAAGAGAGCGCAGATGCTGCGGGAGGCGGCAGAGGCTGGGGCCGAAGCGAGGCTCG
CCCTGGACGGGGAGACGCTGGGCGAGGAGGAACAGGAGGATGAGCAGCCACCCTGGGCCAGCCCGAGCCCCACCTCAAGGCAGAGCCCGG
CGTCCCCCCCACCCCTGGGAGGTGGCGCCCCGGTGCGGACGGCCAAAGCTGAACGGCGCCACCAGGAGCGGCTGCGCGTGCAGAGTCCGG
AGCCACCGGCACCCGAGCGTGCCCTGTCCCCTGCCGAGCTCCGGGCCCTGGAGGCCGAGAAGCGTGCGCTGTGGAGGGCAGCCAGGATGA
AGTCATTGGAACAGGACGCTCTCCGAGCACAGATGGTCCTCAGCAGGTCCCAGGAAGGCCGGGGCACGCGGGGGCCCCTGGAGCGACTGG
CCGAGGCCCCTTCCCCTGCGCCCACCCCGTCGCCCACCCCTGTGGAAGACCTCGGCCCCCAGACCAGCACCTCCCCGGGACGCCTGCCCT
TGTCTGGAAAGAAGTTTGACTACAGGGCCTTTGCGGCCCTGCCTTCTTCCAGACCTGTCTATGACATCCAGTCACCGGACTTTGCTGAGG
AGTTGAGGTCCCTGGAACCATCTCCCAGCCCTGGCCCGCAGGAGGAGGATGGAGAAGTGGCTCTGGTGCTTCTGGGCAGGCCCTCACCCG
GCGCTGTGGGCCCTGAAGATGTGGCACTGTGCAGCAGCCGCCGCCCCGTAAGGCCTGGGCGCCGTGGCCTGGGCCCTGTGCCCTCCTAGA
GGAGCAGGCACCTCCCCCAGACTTGGGGTGGGGGCCCTGCCAGCTCCAGCACCACCCTTGCCCCAAGTCTTTTAACCTGGGTGTTAGCAT
TTTAAAGAGACCCCACAGGAGTTCTGGCCTGTGACTAACTAACTGCCCCACCCCAGCCGAGACCTCGGCGAGACTGTAACTAGTGATGTT

>100561_100561_2_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000356994_length(amino acids)=1698AA_BP=769
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADH
AVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHT
DQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR
RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRP
LLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKLTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG
PAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPL
RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE
REAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVF
ISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR
DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGH
RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSP
PSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQ
QKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSP
AELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPLSGKKFDYRAF

--------------------------------------------------------------
>100561_100561_3_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000377533_length(transcript)=5291nt_BP=2339nt
GGGGGCCTGGCCGGCCGTCGCGGACTCGGGAGATGGAGGAAAAGGAGATATTACGGCGGCAGATCCGCCTACTGCAGGGTCTGATTGATG
ACTACAAAACCCTCCACGGCAATGCCCCGGCCCCTGGTACCCCAGCAGCTTCTGGGTGGCAGCCACCCACTTACCACAGTGGCAGAGCCT
TTAGTGCCCGCTACCCTCGTCCAAGCCGGAGGGGCTACTCTTCCCACCATGGGCCTTCGTGGCGCAAGAAATACTCCCTCGTGAATCGGC
CCCCGGGACCCTCAGACCCTCCTGCCGACCATGCTGTGCGGCCGTTGCACGGGGCCCGGGGGGGCCAGCCTCCTGTCCCGCAGCAGCATG
TCCTTGAGAGACAGGTCCAGCTCAGTCAGGGTCAGAACGTGGTCATCAAAGTTAAACCGCCATCAAAGTCTGGCTCTGCCAGTGCCTCAG
GGGCCCAGCGGGGCTCTTTGGAAGAATTTGAGGAAACCCCCTGGAGTGACCAAAGGCCCCGGGAAGGTGAAGGTGAGCCCCCTCGGGGAC
AGCTGCAGCCCTCGAGGCCAACAAGAGCCAGGGGGACCTGCAGTGTGGAAGATCCTCTTCTGGTCTGCCAGAAGGAGCCTGGTAAGCCCA
GGATGGTGAAGTCAGTGGGCAGTGTGGGCGACAGCCCCCGGGAGCCCCGCCGGACAGTCAGTGAGAGTGTGATTGCCGTCAAGGCGAGCT
TCCCATCCTCCGCTCTGCCCCCACGCACTGGCGTGGCCCTGGGCCGGAAGCTGGGTTCTCATTCCGTGGCCAGCTGTGCTCCACAGCTCC
TTGGGGACAGGAGAGTAGATGCTGGCCACACAGATCAGCCAGTTCCGTCTGGCTCAGTGGGGGGCCCCGCCAGACCGGCCTCAGGACCCA
GGCAGGCCCGGGAGGCCTCGCTGGTTGTGACCTGTCGAACTAACAAGTTCCGGAAAAACAACTACAAATGGGTGGCTGCCTCCTCGAAGA
GTCCCCGGGTTGCTCGGAGGGCCCTCAGTCCCAGAGTGGCTGCAGAGAATGTGTGCAAGGCCTCTGCTGGCATGGCAAACAAGGTGGAGA
AGCCGCAGCTCATAGCTGACCCAGAGCCCAAGCCCAGGAAGCCAGCCACGTCCTCCAAGCCAGGGTCTGCCCCCAGCAAGTACAAGTGGA
AGGCCTCCAGCCCCTCTGCCTCCTCCTCTTCCTCCTTCCGTTGGCAGTCGGAGGCCAGCAGCAAGGACCATGCCTCCCAGCTCTCCCCAG
TCCTGTCTAGGTCCCCGTCGGGGGACAGACCAGCAGTAGGACACAGTGGCTTGAAGCCCCTCTCTGGGGAGACCCCGCTCTCGGCTTACA
AAGTGAAGAGCCGCACCAAGATCATCCGGAGACGCAGCAGCACAAGCCTTCCTGGAGACAAGAAAAGCGGCACCTCACCTGCCGCCACCG
CCAAGAGCCACCTCAGCCTCCGGCGGAGACAGGCCCTCAGGGGGAAGAGCAGCCCTGTCCTGAAGAAGACCCCCAACAAGGGCCTGGTAC
AGGTCACCACGCACCGACTATGTCGCCTGCCACCGAGCCGGGCCCACCTCCCCACCAAGGAAGCGTCCAGCCTGCATGCCGTGCGGACTG
CACCCACCAGCAAGGTGATCAAGACCCGCTACCGCATTGTCAAGAAGACGCCGGCCTCGCCTCTCAGCGCCCCGCCCTTCCCCCTGTCTC
TGCCCTCCTGGCGGGCCCGGCGGCTCTCACTATCCAGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTGCCAGCGGGGGTGGGAAAGCCC
AACCGGGCTCCCCTTGGTGGCGGAGCAAAGGCTACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTGCCAACAAGCTCTCCAAGACCT
CCGGCCAGCCCAGTGATGCGGGCAGCAGGCCCCTCCTGCGCACAGGCCGGCTGGATCCTGCAGGCAGCTGTAGCCGTTCCCTGGCCAGCC
GGGCAGTGCAGCGCAGCCTGGCCATCATCCGGCAGGCGCGGCAGCGCAGGGAGAAGAGGAAGGAGTACTGCATGTACTACAACCGCTTCG
GCAGGTGCAACCGTGGCGAGCGCTGCCCCTACATCCACGATCCCGAGAAGGTGGCCGTGTGCACCAGGTTTGTCCGGGGCACCTGCAAGA
AAACGGATGGGACCTGCCCCTTCTCCCACCATGTGTCCAAGGAGAAGATGCCGGTGTGCTCCTACTTCCTGAAGGGCATCTGCAGCAACA
GCAACTGTCCCTATAGCCACGTGTACGTGTCCCGCAAGGCCGAGGTCTGCAGCGACTTCCTCAAAGGCTACTGCCCCCTGGGTGCAAAGC
TGACCCTCACTATCCTGCGGCAGACTGGGGGCCTGGGCATCAGCATTGCGGGCGGCAAGGGCTCCACACCCTATAAGGGGGACGACGAGG
GCATATTCATCTCTCGGGTGTCCGAGGAAGGCCCTGCGGCCCGGGCTGGAGTCCGTGTGGGTGACAAGCTCCTGGAGGTGAATGGTGTGG
CTCTGCAGGGCGCCGAGCACCACGAGGCCGTGGAGGCGCTCCGGGGGGCCGGCACTGCCGTGCAGATGCGAGTGTGGCGGGAGCGCATGG
TGGAGCCTGAGAACGCGGTCACCATCACGCCGCTGCGGCCCGAGGATGATTACAGCCCCCGAGAGCGGCGGGGAGGGGGGCTGCGCCTGC
CCCTGCTCCCGCCTGAGAGCCCCGGGCCCCTCCGTCAGCGCCACGTGGCCTGCCTGGCACGCAGCGAGAGGGGGCTGGGCTTCAGCATTG
CTGGTGGGAAAGGCTCCACACCCTACAGGGCTGGTGATGCGGGCATCTTCGTCTCCCGCATTGCCGAGGGCGGTGCTGCTCACCGCGCGG
GCACACTGCAGGTTGGCGACCGCGTCCTCTCTATTAATGGAGTGGACGTGACTGAGGCCAGGCATGACCACGCCGTCTCCCTGCTGACCG
CTGCCTCCCCCACCATCGCCCTGCTGTTGGAGCGGGAGGCTGGGGGCCCTCTTCCTCCCAGCCCTCTGCCACATTCCTCACCCCCCACCG
CTGCTGTTGCCACCACCAGCATAACCACTGCCACCCCCGGGGTGCCTGGGTTGCCGAGCCTGGCCCCCAGCCTGCTGGCTGCCGCGTTGG
AAGGGCCATACCCAGTGGAGGAGATCCGTCTGCCAAGAGCTGGGGGCCCTCTGGGGCTTAGTATTGTCGGAGGCTCCGACCATTCCAGCC
ACCCGTTTGGTGTCCAGGAGCCTGGTGTGTTCATCTCCAAGGTGCTCCCGCGGGGCCTGGCCGCTCGCAGCGGCCTGCGGGTTGGGGACC
GCATCCTGGCAGTGAACGGGCAAGACGTGCGGGATGCCACGCACCAAGAAGCAGTCAGTGCCCTGCTCCGGCCCTGCCTGGAGCTGTCGC
TGCTGGTGCGGAGGGACCCGGCACCCCCGGGCCTACGGGAACTGTGCATCCAGAAGGCACCTGGGGAGAGGCTGGGCATCAGCATCCGCG
GGGGTGCCAGGGGCCACGCTGGCAACCCCCGCGACCCCACAGACGAGGGCATCTTCATCTCCAAGGTGAGCCCCACGGGGGCAGCCGGGC
GCGACGGTCGGCTGCGTGTGGGTTTGCGGCTGTTGGAGGTGAACCAGCAGAGCCTGCTGGGCCTGACGCACGGCGAGGCGGTGCAGCTGC
TCCGCAGTGTGGGCGACACCCTCACCGTGCTGGTCTGTGACGGCTTTGAGGCCAGCACCGACGCAGCCCTGGAGGTGTCCCCAGGTGTCA
TTGCCAACCCCTTTGCGGCAGGCATCGGCCACCGGAACAGCCTGGAGAGCATCTCTTCCATCGACCGGGAGCTGAGCCCTGAGGGCCCAG
GCAAGGAGAAGGAGCTGCCTGGACAGACCCTGCACTGGGGGCCCGAGGCCACAGAAGCCGCAGGTCGGGGTCTGCAGCCCCTGAAGCTGG
ACTACCGCGCCCTGGCCGCCGTGCCCAGCGCTGGCAGCGTGCAGAGGGTACCGTCTGGAGCAGCTGGAGGGAAGATGGCTGAATCTCCCT
GCTCCCCTAGTGGCCAGCAGCCGCCCTCCCCGCCTTCTCCGGATGAGCTGCCCGCCAATGTGAAGCAGGCCTACAGGGCCTTCGCGGCCG
TGCCCACTTCTCACCCGCCTGAGGATGCCCCTGCCCAGCCCCCCACGCCTGGGCCTGCAGCCTCCCCGGAGCAGCTGTCCTTCCGGGAGC
GGCAGAAGTACTTTGAGCTGGAGGTGCGCGTGCCCCAGGCCGAGGGCCCCCCTAAGCGCGTGTCCCTGGTGGGTGCTGACGACCTGCGGA
AGATGCAGGAGGAGGAAGCCAGAAAACTACAGCAGAAGAGAGCGCAGATGCTGCGGGAGGCGGCAGAGGCTGGGGCCGAAGCGAGGCTCG
CCCTGGACGGGGAGACGCTGGGCGAGGAGGAACAGGAGGATGAGCAGCCACCCTGGGCCAGCCCGAGCCCCACCTCAAGGCAGAGCCCGG
CGTCCCCCCCACCCCTGGGAGGTGGCGCCCCGGTGCGGACGGCCAAAGCTGAACGGCGCCACCAGGAGCGGCTGCGCGTGCAGAGTCCGG
AGCCACCGGCACCCGAGCGTGCCCTGTCCCCTGCCGAGCTCCGGGCCCTGGAGGCCGAGAAGCGTGCGCTGTGGAGGGCAGCCAGGATGA
AGTCATTGGAACAGGACGCTCTCCGAGCACAGATGGTCCTCAGCAGGTCCCAGGAAGGCCGGGGCACGCGGGGGCCCCTGGAGCGACTGG
CCGAGGCCCCTTCCCCTGCGCCCACCCCGTCGCCCACCCCTGTGGAAGACCTCGGCCCCCAGACCAGCACCTCCCCGGGACGCCTGTCAC
CGGACTTTGCTGAGGAGTTGAGGTCCCTGGAACCATCTCCCAGCCCTGGCCCGCAGGAGGAGGATGGAGAAGTGGCTCTGGTGCTTCTGG
GCAGGCCCTCACCCGGCGCTGTGGGCCCTGAAGATGTGGCACTGTGCAGCAGCCGCCGCCCCGTAAGGCCTGGGCGCCGTGGCCTGGGCC
CTGTGCCCTCCTAGAGGAGCAGGCACCTCCCCCAGACTTGGGGTGGGGGCCCTGCCAGCTCCAGCACCACCCTTGCCCCAAGTCTTTTAA
CCTGGGTGTTAGCATTTTAAAGAGACCCCACAGGAGTTCTGGCCTGTGACTAACTAACTGCCCCACCCCAGCCGAGACCTCGGCGAGACT

>100561_100561_3_ZC3H3-SCRIB_ZC3H3_chr8_144547887_ENST00000262577_SCRIB_chr8_144889183_ENST00000377533_length(amino acids)=1673AA_BP=769
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADH
AVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHT
DQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR
RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRP
LLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKLTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG
PAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPL
RQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLE
REAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVF
ISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR
DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGH
RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSP
PSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQ
QKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSP
AELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLSPDFAEELRSLE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZC3H3-SCRIB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SCRIB	chr8:144547887	chr8:144889183	ENST00000377533		15	36	717_1229	645.0	1550.0	ARHGEF7
Tgene	SCRIB	chr8:144547887	chr8:144889183	ENST00000320476		15	36	1105_1117	726.0	1631.0	tick-borne encephalitis virus RNA-directed RNA polymerase NS5
Tgene	SCRIB	chr8:144547887	chr8:144889183	ENST00000356994		15	37	1105_1117	726.0	1656.0	tick-borne encephalitis virus RNA-directed RNA polymerase NS5
Tgene	SCRIB	chr8:144547887	chr8:144889183	ENST00000377533		15	36	1105_1117	645.0	1550.0	tick-borne encephalitis virus RNA-directed RNA polymerase NS5

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SCRIB	chr8:144547887	chr8:144889183	ENST00000320476		15	36	717_1229	726.0	1631.0	ARHGEF7
Tgene	SCRIB	chr8:144547887	chr8:144889183	ENST00000356994		15	37	717_1229	726.0	1656.0	ARHGEF7

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZC3H3-SCRIB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZC3H3-SCRIB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source