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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ZC3H7B-L3MBTL2 (FusionGDB2 ID:100591)

Fusion Gene Summary for ZC3H7B-L3MBTL2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H7B-L3MBTL2
Fusion gene ID: 100591
HgeneTgene
Gene symbol

ZC3H7B

L3MBTL2

Gene ID

23264

83746

Gene namezinc finger CCCH-type containing 7BL3MBTL histone methyl-lysine binding protein 2
SynonymsROXAN1|RoXaNH-l(3)mbt-l|L3MBT
Cytomap

22q13.2

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 7BRotavirus 'X' associated non-structural proteinrotavirus 'X'-associated non-structural proteinrotavirus X protein associated with NSP3ubiquitous tetratricopeptide containing protein RoXaNlethal(3)malignant brain tumor-like protein 2H-l(3)mbt-like protein 2L(3)mbt-like protein 2L3MBTL2, polycomb repressive complex 1 subunitl(3)mbt-like 2
Modification date2020031320200313
UniProtAcc.

Q969R5

Ensembl transtripts involved in fusion geneENST00000351589, ENST00000352645, 
ENST00000489136, ENST00000216237, 
Fusion gene scores* DoF score15 X 12 X 9=16203 X 8 X 4=96
# samples 187
** MAII scorelog2(18/1620*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZC3H7B [Title/Abstract] AND L3MBTL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZC3H7B(41697776)-L3MBTL2(41615423), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZC3H7B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across L3MBTL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A6SB-01AZC3H7Bchr22

41723368

-L3MBTL2chr22

41605700

+
ChimerDB4BRCATCGA-EW-A6SB-01AZC3H7Bchr22

41723368

+L3MBTL2chr22

41605700

+
ChimerDB4LIHCTCGA-2Y-A9H3-01AZC3H7Bchr22

41723368

-L3MBTL2chr22

41620024

+
ChimerDB4LIHCTCGA-CC-A9FU-01AZC3H7Bchr22

41697776

-L3MBTL2chr22

41615423

+
ChimerDB4LIHCTCGA-CC-A9FU-01AZC3H7Bchr22

41697776

+L3MBTL2chr22

41615423

+


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Fusion Gene ORF analysis for ZC3H7B-L3MBTL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000351589ENST00000489136ZC3H7Bchr22

41723368

+L3MBTL2chr22

41605700

+
5CDS-3UTRENST00000352645ENST00000489136ZC3H7Bchr22

41723368

+L3MBTL2chr22

41605700

+
5CDS-intronENST00000351589ENST00000489136ZC3H7Bchr22

41723368

-L3MBTL2chr22

41620024

+
5CDS-intronENST00000352645ENST00000489136ZC3H7Bchr22

41723368

-L3MBTL2chr22

41620024

+
5UTR-3CDSENST00000352645ENST00000216237ZC3H7Bchr22

41697776

+L3MBTL2chr22

41615423

+
5UTR-intronENST00000352645ENST00000489136ZC3H7Bchr22

41697776

+L3MBTL2chr22

41615423

+
In-frameENST00000351589ENST00000216237ZC3H7Bchr22

41723368

+L3MBTL2chr22

41605700

+
In-frameENST00000351589ENST00000216237ZC3H7Bchr22

41723368

-L3MBTL2chr22

41620024

+
In-frameENST00000352645ENST00000216237ZC3H7Bchr22

41723368

+L3MBTL2chr22

41605700

+
In-frameENST00000352645ENST00000216237ZC3H7Bchr22

41723368

-L3MBTL2chr22

41620024

+
intron-3CDSENST00000351589ENST00000216237ZC3H7Bchr22

41697776

+L3MBTL2chr22

41615423

+
intron-intronENST00000351589ENST00000489136ZC3H7Bchr22

41697776

+L3MBTL2chr22

41615423

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000352645ZC3H7Bchr2241723368+ENST00000216237L3MBTL2chr2241605700+38157012542794846
ENST00000351589ZC3H7Bchr2241723368+ENST00000216237L3MBTL2chr2241605700+355844402537845
ENST00000352645ZC3H7Bchr2241723368-ENST00000216237L3MBTL2chr2241620024+28977012541876540
ENST00000351589ZC3H7Bchr2241723368-ENST00000216237L3MBTL2chr2241620024+264044401619539

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000352645ENST00000216237ZC3H7Bchr2241723368+L3MBTL2chr2241605700+0.0027544720.99724555
ENST00000351589ENST00000216237ZC3H7Bchr2241723368+L3MBTL2chr2241605700+0.0028235520.9971764
ENST00000352645ENST00000216237ZC3H7Bchr2241723368-L3MBTL2chr2241620024+0.0045070.99549294
ENST00000351589ENST00000216237ZC3H7Bchr2241723368-L3MBTL2chr2241620024+0.0046262170.9953738

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Fusion Genomic Features for ZC3H7B-L3MBTL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZC3H7Bchr2241723368+L3MBTL2chr2241605699+3.40E-101
ZC3H7Bchr2241697776+L3MBTL2chr2241615422+2.66E-091
ZC3H7Bchr2241723368+L3MBTL2chr2241605699+3.40E-101
ZC3H7Bchr2241697776+L3MBTL2chr2241615422+2.66E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZC3H7B-L3MBTL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41697776/chr22:41615423)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.L3MBTL2

Q969R5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+4221_27148978.0RepeatTPR 1
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+42236_69148978.0RepeatTPR 2
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+42282_115148978.0RepeatTPR 3
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+5231_27148978.0RepeatTPR 1
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+52336_69148978.0RepeatTPR 2
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+52382_115148978.0RepeatTPR 3
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-4221_27148978.0RepeatTPR 1
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-42236_69148978.0RepeatTPR 2
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-42282_115148978.0RepeatTPR 3
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-5231_27148978.0RepeatTPR 1
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-52336_69148978.0RepeatTPR 2
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-52382_115148978.0RepeatTPR 3
TgeneL3MBTL2chr22:41723368chr22:41605700ENST0000021623701717_208706.0Compositional biasNote=Poly-Glu
TgeneL3MBTL2chr22:41723368chr22:41605700ENST00000216237017620_6248706.0Compositional biasNote=Poly-Lys
TgeneL3MBTL2chr22:41723368chr22:41620024ENST00000216237717620_624314706.0Compositional biasNote=Poly-Lys
TgeneL3MBTL2chr22:41723368chr22:41605700ENST00000216237017179_2838706.0RepeatNote=MBT 1
TgeneL3MBTL2chr22:41723368chr22:41605700ENST00000216237017291_3918706.0RepeatNote=MBT 2
TgeneL3MBTL2chr22:41723368chr22:41605700ENST00000216237017397_5008706.0RepeatNote=MBT 3
TgeneL3MBTL2chr22:41723368chr22:41605700ENST00000216237017508_6048706.0RepeatNote=MBT 4
TgeneL3MBTL2chr22:41723368chr22:41620024ENST00000216237717397_500314706.0RepeatNote=MBT 3
TgeneL3MBTL2chr22:41723368chr22:41620024ENST00000216237717508_604314706.0RepeatNote=MBT 4
TgeneL3MBTL2chr22:41723368chr22:41605700ENST0000021623701781_1168706.0Zinc fingerFCS-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+422484_508148978.0Zinc fingerC3H1-type 1
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+422616_638148978.0Zinc fingerC3H1-type 2
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+422754_782148978.0Zinc fingerC3H1-type 3
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+422842_866148978.0Zinc fingerC2H2-type
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000351589+422886_914148978.0Zinc fingerC3H1-type 4
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+523484_508148978.0Zinc fingerC3H1-type 1
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+523616_638148978.0Zinc fingerC3H1-type 2
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+523754_782148978.0Zinc fingerC3H1-type 3
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+523842_866148978.0Zinc fingerC2H2-type
HgeneZC3H7Bchr22:41723368chr22:41605700ENST00000352645+523886_914148978.0Zinc fingerC3H1-type 4
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-422484_508148978.0Zinc fingerC3H1-type 1
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-422616_638148978.0Zinc fingerC3H1-type 2
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-422754_782148978.0Zinc fingerC3H1-type 3
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-422842_866148978.0Zinc fingerC2H2-type
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000351589-422886_914148978.0Zinc fingerC3H1-type 4
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-523484_508148978.0Zinc fingerC3H1-type 1
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-523616_638148978.0Zinc fingerC3H1-type 2
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-523754_782148978.0Zinc fingerC3H1-type 3
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-523842_866148978.0Zinc fingerC2H2-type
HgeneZC3H7Bchr22:41723368chr22:41620024ENST00000352645-523886_914148978.0Zinc fingerC3H1-type 4
TgeneL3MBTL2chr22:41723368chr22:41620024ENST0000021623771717_20314706.0Compositional biasNote=Poly-Glu
TgeneL3MBTL2chr22:41723368chr22:41620024ENST00000216237717179_283314706.0RepeatNote=MBT 1
TgeneL3MBTL2chr22:41723368chr22:41620024ENST00000216237717291_391314706.0RepeatNote=MBT 2
TgeneL3MBTL2chr22:41723368chr22:41620024ENST0000021623771781_116314706.0Zinc fingerFCS-type


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Fusion Gene Sequence for ZC3H7B-L3MBTL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100591_100591_1_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000351589_L3MBTL2_chr22_41605700_ENST00000216237_length(transcript)=3558nt_BP=444nt
ATGGAGAGGCAGAAACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCC
TTTCTGCTCAAGCTGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATG
GAAGGGCTGAACGTGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCC
TGCTACTTCACCATGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTC
CGCAAGGCACGCGCTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACGAGACC
CCATCTTCAGAACCAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTG
GGCAGTGAGAGCAGCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCAT
TTGCTCAGCCCTGGGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAA
GCCTTCTTCTCCAAGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGG
TTACAGGGAAAACCACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGG
ACAGGACAGCTGGCAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTAC
AAGGCTGCTCCCGTCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAAC
AGTGATGCTGTGCTCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTT
GAAAATGACGCCAGCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTA
GTGCCCCCACGGACCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGAT
TTCCACATCAAGATGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACT
CGCATGGCTGTGGTGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATG
TGGAGCCCCCTGATCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCAC
CCCACCTTCCGGAAGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAA
GGGATGAAGCTGGAGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATG
ATCTGTGTGGACGGGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGT
CAGAAGAATGACATTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAA
GCCGCTCCATCGAGACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCC
CGGCTCATCTGTGTGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGG
GTGGACTGCGAGTCCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCC
ACACCGCTGAAGGCCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCC
CTCAGACAGGGGTCCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATT
GCTGTGCGTGTGAAGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAG
CAGGAAACAGACGACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTC
CACCTGACTTTGGCTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTC
CTGGGACCCGCCTGTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCT
TTTCCAGCCAGAGTTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCC
AGGGATGGGGCCACCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAG
CTCTCTGAGCAGGATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAG
CCTCATGTGTTGGTCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATG
TGGATTTTGGCGACCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGA
GGACATTGGGAGGAAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCT
TTGTAGTTAAAGGGTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAA
ACCATGCCTGGAGGGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTG

>100591_100591_1_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000351589_L3MBTL2_chr22_41605700_ENST00000216237_length(amino acids)=845AA_BP=148
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHETPSSEPMEEEEDDDLELFGGYDSFRSYNSSV
GSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILAR
LQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLN
SDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVD
FHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHH
PTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFC
QKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQW
VDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEII

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>100591_100591_2_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000351589_L3MBTL2_chr22_41620024_ENST00000216237_length(transcript)=2640nt_BP=444nt
ATGGAGAGGCAGAAACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCC
TTTCTGCTCAAGCTGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATG
GAAGGGCTGAACGTGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCC
TGCTACTTCACCATGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTC
CGCAAGGCACGCGCTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACATGGTG
GAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGCTGTGGTGGAC
ACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCCCCTGATCCAC
CCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTTCCGGAAGATC
TACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAAGCTGGAGGCC
ATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGTGGACGGGGGG
CCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAATGACATTGAG
CTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCCATCGAGACTC
TTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCATCTGTGTGGCC
ACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTGCGAGTCCCCA
GACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCTGAAGGCCAAA
GAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACAGGGGTCCAAG
AAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCGTGTGAAGGAA
GAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAACAGACGACTGA
GCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGACTTTGGCTTGG
AGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACCCGCCTGTTGC
TTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGCCAGAGTTCCC
AAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGGGGCCACCACT
GTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGAGCAGGATAAG
GTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGTGTTGGTCCTC
TGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTTGGCGACCTGT
GTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTGGGAGGAAGAT
GGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTTAAAGGGTCCA
GTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCCTGGAGGGGCC
GTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCCAGACTCTGTG

>100591_100591_2_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000351589_L3MBTL2_chr22_41620024_ENST00000216237_length(amino acids)=539AA_BP=148
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVD
TVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEA
IDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRL
FNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAK

--------------------------------------------------------------
>100591_100591_3_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000352645_L3MBTL2_chr22_41605700_ENST00000216237_length(transcript)=3815nt_BP=701nt
AGGGAGACAGTGCCTCCAGCGGGTGCTGCCGCGAGCGGCCAGCCGAGGGGCTGGAAATGAAAGTAAAGCGCTCCAGAGCCACATGGACGG
AGCTGCCGGGGCGGCGGCGCCGGGAGCAGGATGCGGCCGCCCGTAATTAAATAGCATTTACTCTTATTATTACTAATAATAATAACGTAA
TCATACCTCTAGTCATAGCATACCATTTATCGGGCTCGGCGCAGGCCCGCGGGGAGCGCAGCCCGGCGGAGAGACTGATGGAGAGGCAGA
AACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCCTTTCTGCTCAAGC
TGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATGGAAGGGCTGAACG
TGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCCTGCTACTTCACCA
TGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTCCGCAAGGCACGCG
CTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACGAGACCCCATCTTCAGAAC
CAATGGAGGAAGAGGAAGATGACGACTTGGAGCTGTTTGGTGGCTATGATAGTTTCCGGAGTTATAACAGCAGTGTGGGCAGTGAGAGCA
GCTCCTATCTGGAGGAGTCAAGTGAAGCAGAAAATGAGGATCGGGAAGCAGGGGAACTGCCGACCTCCCCGCTGCATTTGCTCAGCCCTG
GGACTCCTCGCTCCTTGGATGGCAGTGGTTCTGAGCCAGCTGTCTGTGAGATGTGTGGTATCGTGGGTACAAGGGAAGCCTTCTTCTCCA
AGACCAAGAGGTTCTGCAGCGTCTCCTGCTCCAGGAGCTACTCCTCCAACTCCAAGAAAGCCAGTATCTTGGCTAGGTTACAGGGAAAAC
CACCGACCAAAAAAGCCAAAGTCCTGCACAAGGCTGCCTGGTCTGCCAAAATTGGAGCCTTCCTCCACTCTCAAGGGACAGGACAGCTGG
CAGATGGGACACCAACAGGACAAGACGCTCTGGTCTTGGGCTTCGACTGGGGGAAGTTCCTGAAGGATCACAGTTACAAGGCTGCTCCCG
TCAGCTGTTTCAAGCACGTCCCACTCTATGACCAGTGGGAGGATGTGATGAAAGGGATGAAGGTGGAGGTGCTCAACAGTGATGCTGTGC
TCCCCAGCCGGGTGTACTGGATCGCCTCTGTCATCCAGACAGCAGGGTATCGGGTGCTGCTTCGGTATGAAGGCTTTGAAAATGACGCCA
GCCATGACTTCTGGTGCAACCTGGGAACAGTGGATGTCCACCCCATTGGCTGGTGTGCCATCAACAGCAAGATCCTAGTGCCCCCACGGA
CCATCCATGCCAAGTTCACCGACTGGAAGGGCTACCTCATGAAACGGCTGGTGGGCTCCAGGACGCTTCCCGTGGATTTCCACATCAAGA
TGGTGGAGAGCATGAAGTACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGCTGTGG
TGGACACAGTAATCGGGGGTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCCCCTGA
TCCACCCAGTGGGTTGGTCACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTTCCGGA
AGATCTACTGTGATGCCGTTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAAGCTGG
AGGCCATTGACCCCCTGAATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGTGGACG
GGGGGCCCTCCACAGATGGCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAATGACA
TTGAGCTCACACCGCCAAAAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCCATCGA
GACTCTTTAACATGGATTGCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCATCTGTG
TGGCCACGGTGAAACGAGTGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTGCGAGT
CCCCAGACATCTACCCCGTCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCTGAAGG
CCAAAGAGGCCACAAAGAAGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACAGGGGT
CCAAGAAGCCCCTGCTGGAGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCGTGTGA
AGGAAGAGCATCTAGACGTGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAACAGACG
ACTGAGCCTTCCTGCCTCCAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGACTTTGG
CTTGGAGACTGATCCTCTCTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACCCGCCT
GTTGCTTCTGCCCTCCCCTGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGCCAGAG
TTCCCAAAGCTGGAACGCTAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGGGGCCA
CCACTGTCACACTGTGGAATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGAGCAGG
ATAAGGTCCCCTGACAGTGAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGTGTTGG
TCCTCTGCTCCTCCTAGCTCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTTGGCGA
CCTGTGTGGTGGCCTTGAGCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTGGGAGG
AAGATGGCCTGAGTGTGCACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTTAAAGG
GTCCAGTTCTGACTGGAGCCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCCTGGAG
GGGCCGTGAACACAGAACCCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCCAGACT

>100591_100591_3_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000352645_L3MBTL2_chr22_41605700_ENST00000216237_length(amino acids)=846AA_BP=149
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHETPSSEPMEEEEDDDLELFGGYDSFRSYNSS
VGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILA
RLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVL
NSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPV
DFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAH
HPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATF
CQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQ
WVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEI

--------------------------------------------------------------
>100591_100591_4_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000352645_L3MBTL2_chr22_41620024_ENST00000216237_length(transcript)=2897nt_BP=701nt
AGGGAGACAGTGCCTCCAGCGGGTGCTGCCGCGAGCGGCCAGCCGAGGGGCTGGAAATGAAAGTAAAGCGCTCCAGAGCCACATGGACGG
AGCTGCCGGGGCGGCGGCGCCGGGAGCAGGATGCGGCCGCCCGTAATTAAATAGCATTTACTCTTATTATTACTAATAATAATAACGTAA
TCATACCTCTAGTCATAGCATACCATTTATCGGGCTCGGCGCAGGCCCGCGGGGAGCGCAGCCCGGCGGAGAGACTGATGGAGAGGCAGA
AACGGAAGGCGGACATCGAGAAAGGGCTGCAGTTCATTCAGTCGACACTACCCCTAAAGCAAGAAGAATATGAGGCCTTTCTGCTCAAGC
TGGTGCAGAATCTGTTTGCTGAGGGCAATGATCTGTTCCGGGAGAAGGACTATAAGCAGGCTCTGGTGCAGTACATGGAAGGGCTGAACG
TGGCCGACTACGCTGCCTCTGACCAGGTGGCCCTGCCCCGGGAGCTGCTGTGCAAGCTGCATGTCAATAGGGCCGCCTGCTACTTCACCA
TGGGCCTGTATGAGAAGGCGCTGGAGGACAGCGAGAAGGCGCTGGGCCTGGACAGTGAGAGTATCCGGGCGTTGTTCCGCAAGGCACGCG
CTCTCAATGAACTGGGACGCCACAAGGAGGCCTACGAGTGCAGCAGCCGGTGTTCCCTCGCCCTGCCCCACATGGTGGAGAGCATGAAGT
ACCCCTTTAGGCAGGGCATGCGGCTGGAAGTGGTGGACAAGTCCCAGGTGTCACGCACTCGCATGGCTGTGGTGGACACAGTAATCGGGG
GTCGCCTACGGCTCCTCTACGAGGATGGTGACAGTGACGACGACTTCTGGTGCCACATGTGGAGCCCCCTGATCCACCCAGTGGGTTGGT
CACGACGTGTGGGCCACGGCATCAAGATGTCAGAGAGGCGAAGTGACATGGCCCATCACCCCACCTTCCGGAAGATCTACTGTGATGCCG
TTCCTTACCTCTTCAAGAAGGTACGAGCAGTCTACACAGAAGGCGGTTGGTTTGAGGAAGGGATGAAGCTGGAGGCCATTGACCCCCTGA
ATCTGGGCAACATCTGCGTGGCAACTGTCTGTAAGGTTCTCCTGGATGGATACCTGATGATCTGTGTGGACGGGGGGCCCTCCACAGATG
GCTTGGACTGGTTCTGCTACCATGCCTCTTCCCACGCCATCTTCCCGGCCACCTTCTGTCAGAAGAATGACATTGAGCTCACACCGCCAA
AAGGTTATGAGGCACAGACTTTCAACTGGGAGAACTACTTGGAGAAGACCAAGTCGAAAGCCGCTCCATCGAGACTCTTTAACATGGATT
GCCCAAACCATGGCTTCAAGGTGGGCATGAAGCTGGAGGCCGTGGACCTGATGGAGCCCCGGCTCATCTGTGTGGCCACGGTGAAACGAG
TGGTGCATCGGCTCCTCAGCATCCACTTTGACGGCTGGGACAGCGAGTACGACCAGTGGGTGGACTGCGAGTCCCCAGACATCTACCCCG
TCGGCTGGTGTGAGCTCACCGGCTACCAGCTCCAGCCTCCTGTGGCCGCAGAACCGGCCACACCGCTGAAGGCCAAAGAGGCCACAAAGA
AGAAAAAGAAACAGTTTGGGAAGAAAAGGAAAAGAATCCCGCCCACTAAGACGCGACCCCTCAGACAGGGGTCCAAGAAGCCCCTGCTGG
AGGACGACCCTCAGGGTGCCAGGAAGATCTCGTCGGAGCCTGTTCCTGGCGAGATCATTGCTGTGCGTGTGAAGGAAGAGCATCTAGACG
TGGCCTCGCCCGACAAGGCTTCAAGTCCAGAGCTGCCTGTCTCCGTCGAGAACATCAAGCAGGAAACAGACGACTGAGCCTTCCTGCCTC
CAGCCTGGCTTCTAGCTGGAAGCCAGCCCAGCGTTTCTCTACCACCACCACCATGCCTCCACCTGACTTTGGCTTGGAGACTGATCCTCT
CTGTGTAAATTCTGCCCGGTGCTGTGAAGGCTGGACGGTGGAGGACCTGCTGGGGTCTCCTGGGACCCGCCTGTTGCTTCTGCCCTCCCC
TGTGGAAAGGTCTATATGACGGGCCGCCTGAGGCCCCAGAACTCGTCTGTGAACCACCTTTTCCAGCCAGAGTTCCCAAAGCTGGAACGC
TAGCTGCCTGCTCTTCCTTAAGATGGCCTCCCCCCGACCCGCCACGGCCCTCAGTTGCCAGGGATGGGGCCACCACTGTCACACTGTGGA
ATACAAGACAGTGAACTCTGTCTGCCTGAACGAGCCATGTAAATTAAGTTCTAGAGCAGCTCTCTGAGCAGGATAAGGTCCCCTGACAGT
GAGTTGTGTGGTGGGGGCAGCCTCTGCCTCAAAAATTCACCAAGCAGAATGCCTCTCAGCCTCATGTGTTGGTCCTCTGCTCCTCCTAGC
TCCCCAGGGATGTTGGGGACCCAGCTTGTCTCGGCAGCTAAGAAGCAGTGACCAGGATGTGGATTTTGGCGACCTGTGTGGTGGCCTTGA
GCTGCTTTCTGTGTTTGTGAGGACTGACTCCCATTTCCTAAAGGAAATGCCCCCGGGGAGGACATTGGGAGGAAGATGGCCTGAGTGTGC
ACTTTGGCTCTGCTACCTGCTCCTGAAGCCCCGCTAAAAATAATTCATCCAAGATTCCTTTGTAGTTAAAGGGTCCAGTTCTGACTGGAG
CCTCTAGAGAGCTGGGCTTGTATGTTCTTTTGGCCTTTTGTTCCTACCTAAATGAAGAAACCATGCCTGGAGGGGCCGTGAACACAGAAC
CCTCAAGACAAGGATGACAGAGCTGGAGGACACATCTAGCTGCCATTGCAACCTCACTGGGCTCCCCAGACTCTGTGTGTGAGAAATTAA

>100591_100591_4_ZC3H7B-L3MBTL2_ZC3H7B_chr22_41723368_ENST00000352645_L3MBTL2_chr22_41620024_ENST00000216237_length(amino acids)=540AA_BP=149
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHMVESMKYPFRQGMRLEVVDKSQVSRTRMAVV
DTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLE
AIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSR
LFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKA
KEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEIIAVRVKEEHLDVASPDKASSPELPVSVENIKQETDD

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Fusion Gene PPI Analysis for ZC3H7B-L3MBTL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZC3H7B-L3MBTL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZC3H7B-L3MBTL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource