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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZCCHC17-UBXN4 (FusionGDB2 ID:100660)

Fusion Gene Summary for ZCCHC17-UBXN4

Fusion gene summary

Fusion gene information	Fusion gene name: ZCCHC17-UBXN4
	Fusion gene ID: 100660
		Hgene	Tgene
	Gene symbol	ZCCHC17	UBXN4
	Gene ID	51538	23190
	Gene name	zinc finger CCHC-type containing 17	UBX domain protein 4
	Synonyms	HSPC251\|PS1D\|pNO40	UBXD2\|UBXDC1\|erasin
	Cytomap	1p35.2	2q21.3
	Type of gene	protein-coding	protein-coding
	Description	nucleolar protein of 40 kDanucleolar protein 40pnn-interacting nucleolar proteinputative S1 RNA binding domain proteinzinc finger CCHC domain-containing protein 17zinc finger, CCHC domain containing 17	UBX domain-containing protein 4UBX domain containing 2UBX domain-containing 1UBX domain-containing protein 2
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000479629, ENST00000344147, ENST00000373714, ENST00000422613, ENST00000546109,	ENST00000272638, ENST00000490163,
Fusion gene scores	* DoF score	14 X 8 X 6=672	9 X 10 X 3=270
	# samples	16	11
	** MAII score	log2(16/672*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/270*10)=-1.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZCCHC17 [Title/Abstract] AND UBXN4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZCCHC17(31792013)-UBXN4(136505837), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZCCHC17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBXN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GY-01A	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+

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Fusion Gene ORF analysis for ZCCHC17-UBXN4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000479629	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
3UTR-intron	ENST00000479629	ENST00000490163	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
5CDS-intron	ENST00000344147	ENST00000490163	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
5CDS-intron	ENST00000373714	ENST00000490163	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
5CDS-intron	ENST00000422613	ENST00000490163	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
5CDS-intron	ENST00000546109	ENST00000490163	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
In-frame	ENST00000344147	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
In-frame	ENST00000373714	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
In-frame	ENST00000422613	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+
In-frame	ENST00000546109	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000344147

ZCCHC17

chr1

31792013

ENST00000272638

UBXN4

chr2

136505837

3873

260

136

1704

522

ENST00000373714

ZCCHC17

chr1

31792013

ENST00000272638

UBXN4

chr2

136505837

3998

385

153

1829

558

ENST00000546109

ZCCHC17

chr1

31792013

ENST00000272638

UBXN4

chr2

136505837

3906

293

115

1737

540

ENST00000422613

ZCCHC17

chr1

31792013

ENST00000272638

UBXN4

chr2

136505837

3711

1542

498

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000344147	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+	0.000244563	0.99975544
ENST00000373714	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+	0.000260657	0.99973935
ENST00000546109	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+	0.000122218	0.9998778
ENST00000422613	ENST00000272638	ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505837	+	0.00039673	0.99960333

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Fusion Genomic Features for ZCCHC17-UBXN4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505836	+	7.61E-07	0.9999993
ZCCHC17	chr1	31792013	+	UBXN4	chr2	136505836	+	7.61E-07	0.9999993

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZCCHC17-UBXN4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:31792013/chr2:136505837)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UBXN4

chr1:31792013

chr2:136505837

ENST00000272638

315_393

509.0

Domain

UBX

Tgene

UBXN4

chr1:31792013

chr2:136505837

ENST00000272638

414_434

509.0

Intramembrane

Ontology_term=ECO:0000255

Tgene

UBXN4

chr1:31792013

chr2:136505837

ENST00000272638

435_508

509.0

Topological domain

Cytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000344147

110_113

242.0

Compositional bias

Note=Poly-Arg

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000344147

161_167

242.0

Compositional bias

Note=Poly-Glu

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000344147

185_240

242.0

Compositional bias

Note=Lys-rich

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000373714

110_113

242.0

Compositional bias

Note=Poly-Arg

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000373714

161_167

242.0

Compositional bias

Note=Poly-Glu

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000373714

185_240

242.0

Compositional bias

Note=Lys-rich

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000344147

16_88

242.0

Domain

S1 motif

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000373714

16_88

242.0

Domain

S1 motif

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000344147

131_148

242.0

Zinc finger

CCHC-type

Hgene

ZCCHC17

chr1:31792013

chr2:136505837

ENST00000373714

131_148

242.0

Zinc finger

CCHC-type

Tgene

UBXN4

chr1:31792013

chr2:136505837

ENST00000272638

1_413

509.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for ZCCHC17-UBXN4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>100660_100660_1_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000344147_UBXN4_chr2_136505837_ENST00000272638_length(transcript)=3873nt_BP=260nt
CTTGTGGGTGGAAACGCGCTGGCTGACTGGGGTCGGCGTTTAGTTCAGCGCAGCGACTCGGGGACCTGGAGCTGACGCCTAGACACTTGT
ATTAGCTTTAATAGAAGAGAAATGGAGGAGCCATAGAATATTAAGGATGAATTCAGGAAGGCCTGAGACCATGGAAAACTTGCCTGCTCT
CTACACTATTTTCCAAGGAGAGGTTGCTATGGTGACAGACTATGGGGCCTTTATCAAAATCCCAGGCTGTCGGAAGCAAGGTGATGATGA
ACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAGAAGCATCTTCAAACAGTTTTGTTGCTATTAAAATCGATACCAA
AAGTGAAGCCTGCCTACAGTTTTCACAAATCTATCCTGTAGTGTGTGTTCCATCCAGTTTCTTTATTGGAGACAGTGGAATTCCCTTGGA
AGTAATAGCAGGAAGTGTTTCTGCAGATGAACTTGTTACAAGAATTCACAAGGTCCGACAGATGCATTTGCTAAAAAGTGAAACATCAGT
AGCAAATGGCAGTCAGTCAGAAAGTTCAGTGTCTACTCCATCTGCGTCATTTGAACCTAACAACACTTGTGAAAACTCTCAGTCCAGAAA
TGCAGAGCTTTGTGAGATACCACCCACTTCTGATACAAAGTCAGATACTGCAACAGGAGGAGAAAGTGCAGGCCATGCCACTTCCTCTCA
GGAGCCTAGTGGATGCTCAGATCAGAGACCTGCAGAGGACCTCAACATCCGAGTGGAAAGACTAACAAAAAAACTTGAAGAAAGGAGAGA
AGAGAAAAGAAAAGAGGAAGAACAGAGAGAAATTAAGAAGGAAATTGAGAGGAGAAAAACTGGAAAAGAAATGTTGGATTATAAAAGAAA
ACAAGAAGAAGAATTAACAAAAAGAATGCTGGAGGAAAGAAACAGAGAGAAAGCAGAAGATAGGGCAGCTCGAGAACGTATAAAACAGCA
GATTGCATTGGACCGTGCAGAGAGAGCTGCTCGTTTTGCAAAGACAAAGGAAGAAGTAGAGGCTGCCAAAGCTGCTGCCTTGCTAGCAAA
ACAGGCAGAAATGGAAGTCAAGAGGGAATCTTATGCAAGAGAAAGAAGCACTGTTGCAAGAATTCAATTCCGTCTTCCTGATGGTTCTTC
CTTTACAAATCAGTTCCCTTCTGATGCTCCTCTAGAAGAGGCAAGGCAGTTTGCTGCACAGACTGTTGGCAACACTTACGGTAATTTTTC
GTTAGCAACCATGTTTCCCAGGAGGGAATTTACCAAAGAAGATTATAAAAAGAAGTTACTGGATTTGGAACTTGCCCCAAGCGCTTCGGT
GGTACTGTTGCCAGCAGGAAGACCAACTGCATCCATTGTACACTCTTCCAGCGGAGACATTTGGACCTTGTTGGGAACAGTGCTTTATCC
ATTCCTTGCCATCTGGAGATTAATTAGCAATTTCTTGTTTAGTAATCCGCCTCCCACACAGACTTCAGTGAGAGTAACATCGTCAGAACC
CCCAAACCCTGCATCATCTAGCAAATCAGAAAAAAGGGAACCAGTGAGAAAAAGAGTGCTGGAAAAACGTGGAGACGACTTTAAAAAGGA
GGGGAAAATTTATAGATTAAGGACTCAAGATGATGGTGAAGATGAAAACAACACTTGGAATGGAAATTCCACTCAACAGATGTAGTGTGA
CAAGTATAATATGTGCAATAATCATTGTTTCTCTTATGATTTAATTCAACTAAAATTCTACTGGAGAAGTGGGACTGCTTTATATTTTCC
AACTGGTCTATAAAATGTCTCTTTATTCCTGCTTAGTGGGTGTGGGTTGAAGGTGTTTAACTCAGAAAAGTAAAGACAGGAAATAACTCT
CTGCTAGGTCCTTGCTTATATGGCAACCACTGCTAGAACCCTAAAAGAACCAAAAATCTGCCACAGCCTGCCTCCATCAGCTTCTTATTT
AGTATTTCATATGCCCATTAGCCCTATGCTTCAGATGACACGTTTTGTTTAGAGCTACTTTGCTCCAAGACTCTTAAGCCCAAAGTAACT
GGTATGTCACTGAGTAACTTGACTCGGTGTCAGAGCATTTTAACTAGCCACTCAGATGAGAATTTATGTTTAACTTCTCTTTTTACTCAT
CAGCTGCAAGCAAAATCTTGTAGTTTTTAATCTTAAACACTGAATAAAAAAACTTTCCCCTAAATTGGAATGATCTTAGTTTTGCTTTGA
GTTTTGTTATCTAGCATCTTTTTGTTGCACAGGGCTCTATTGAGGTCCTATGTCTCTGATTTTTTTTTTTCCCCAGTATTGCCCTGGAGC
TGTCTCTGGAAAGTAGCTGGCGAGGTTACCTTAACTATCACTGAAGAAAGAAATTTTCTGACACACTGATGGCATGTGACTTGTCTCCTA
AGTCAGTGAGGCATCACTTTGTTTGCATAAAGTATACGGTTTGTTAAGGCCTTTGTTCTTGTGAGATGCAAAACAGCTGCTAGTCTGCAA
CCTAGTTTTCCCTCTCACCTTTAACTGACGTTTTGTCCTCAATAATTACACAAGGACCTAGAGTACCTATAGGACAAAAAGTATAGAATA
AAAATATGCCTTTAGTCATTTGGTTTTTCTTAAAAAGTTGAGATTCTTAATCTGACTTACATGTTACTTTATCCGTATGTCTTTGTTAGT
GGAGACCGCTAAACTAATGATGTTTGAAAACAGTTCCTCTGTTTTAGATTGGAAGATAGCACTCTAGAGTGGACATACGGAAAGACTGTG
ACTTTATTTTGTAATGGGAGGAAGAAATTTTCTCAGAGCAAACTTTCTATTTTTTACCTGTGAAATAACAGTGACTTTTTAAAATGGTGA
CAGTGTTGGCAAGGAAACAGCAACACAGGCTGCGCTGTTGGTAGGAGTGAAAACCAGTATAATTCTTCTGAAAAACATTTATCAGAAACT
TAAAATATTTCATACCGTTTGATCCAGTAGCTTCTTCTAAATCATAAATGCAGACAATGTTTAGGTAAAGACATACTCATTAAGTGTTAT
TTATTTTACTCAAGAACTGGAAACCAACTAAATGCCTTCTATAGAAGTAATTTTTGATGAGGAGAAATGGTACAATACTAATTAACAACT
TGGTTTAACATGTTTACTGAGCATCTGTTAAGTGTTGGGGGAAAAAGCAGCAGGATCCAGAGCTATAGGTACAGTGTGATCTCAGCTTTG
CAAACACATTTTCTACATAGATAGTACTAGGTATTAATAGATATGTAAAGAAAGAAATCACACCATTAATAATGGTAAGATTGGTTTATG
TGATTTTAGTGGTATTTTTGGCACCCTTATATATGTTTTCCAAACTTTCAGCAGTGATATTATTTCCATAACTTAAAAAGTGAGTTTGAA
AAAGAAAATCTCCAGCAAGCATCTCATTTAAATAAAGGTTTGTCATCTTTAAAAATACAGCAATATGTGACTTTTTAAAAAAGCTGTCAA
ATAGGTGTGACCCTACTAATAATTATTAGAAATACATTTAAAAACATCGAGTACCTCAAGTCAGTTTGCCTTGAAAAATATCAAATATAA
CTCTTAGAGAAATGTACATAAAAGAATGCTTCGTAATTTTGGAGTAGGAGGTTCCCTCCTCAATTTTGTATTTTTAAAAGTACATGGTAA
AAAAAAAAATTCACAACAGTATATAAGGCTGTAAAATGAGAATTCTGCCCCCTCACCTCTTACCCCAGTACTATTCTCCAGAGGTAATCT
ATTAACAATTTCTTATGTAATTTTCAGAAAATTTGTATGCGTATATAAGCAAATATGTAATCTTTATTTTTTAAATAAATGGGATCATAT

>100660_100660_1_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000344147_UBXN4_chr2_136505837_ENST00000272638_length(amino acids)=522AA_BP=41
MNSGRPETMENLPALYTIFQGEVAMVTDYGAFIKIPGCRKQGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVC
VPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSD
TATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNR
EKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEAR
QFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSN

--------------------------------------------------------------
>100660_100660_2_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000373714_UBXN4_chr2_136505837_ENST00000272638_length(transcript)=3998nt_BP=385nt
ACGCGCTGGCTGACTGGGGTCGGCGTTTAGTTCAGCGCAGCGACTCGGGGACCTGGAGCTGACGCCTAGTACGTATGAGGAAGAACGGGG
TGGGTGGCTGCCTGAGTCTGGAGGCGACGCCTCGGTTGTGCAGTCTGAACCTGCCCTTCTCAGCTGAGGGTGCTGACAGCAAGGGGTGGG
AGGCGGGCCCCGAGTCCCCAGCTGTGGACACTTGTATTAGCTTTAATAGAAGAGAAATGGAGGAGCCATAGAATATTAAGGATGAATTCA
GGAAGGCCTGAGACCATGGAAAACTTGCCTGCTCTCTACACTATTTTCCAAGGAGAGGTTGCTATGGTGACAGACTATGGGGCCTTTATC
AAAATCCCAGGCTGTCGGAAGCAAGGTGATGATGAACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAGAAGCATCT
TCAAACAGTTTTGTTGCTATTAAAATCGATACCAAAAGTGAAGCCTGCCTACAGTTTTCACAAATCTATCCTGTAGTGTGTGTTCCATCC
AGTTTCTTTATTGGAGACAGTGGAATTCCCTTGGAAGTAATAGCAGGAAGTGTTTCTGCAGATGAACTTGTTACAAGAATTCACAAGGTC
CGACAGATGCATTTGCTAAAAAGTGAAACATCAGTAGCAAATGGCAGTCAGTCAGAAAGTTCAGTGTCTACTCCATCTGCGTCATTTGAA
CCTAACAACACTTGTGAAAACTCTCAGTCCAGAAATGCAGAGCTTTGTGAGATACCACCCACTTCTGATACAAAGTCAGATACTGCAACA
GGAGGAGAAAGTGCAGGCCATGCCACTTCCTCTCAGGAGCCTAGTGGATGCTCAGATCAGAGACCTGCAGAGGACCTCAACATCCGAGTG
GAAAGACTAACAAAAAAACTTGAAGAAAGGAGAGAAGAGAAAAGAAAAGAGGAAGAACAGAGAGAAATTAAGAAGGAAATTGAGAGGAGA
AAAACTGGAAAAGAAATGTTGGATTATAAAAGAAAACAAGAAGAAGAATTAACAAAAAGAATGCTGGAGGAAAGAAACAGAGAGAAAGCA
GAAGATAGGGCAGCTCGAGAACGTATAAAACAGCAGATTGCATTGGACCGTGCAGAGAGAGCTGCTCGTTTTGCAAAGACAAAGGAAGAA
GTAGAGGCTGCCAAAGCTGCTGCCTTGCTAGCAAAACAGGCAGAAATGGAAGTCAAGAGGGAATCTTATGCAAGAGAAAGAAGCACTGTT
GCAAGAATTCAATTCCGTCTTCCTGATGGTTCTTCCTTTACAAATCAGTTCCCTTCTGATGCTCCTCTAGAAGAGGCAAGGCAGTTTGCT
GCACAGACTGTTGGCAACACTTACGGTAATTTTTCGTTAGCAACCATGTTTCCCAGGAGGGAATTTACCAAAGAAGATTATAAAAAGAAG
TTACTGGATTTGGAACTTGCCCCAAGCGCTTCGGTGGTACTGTTGCCAGCAGGAAGACCAACTGCATCCATTGTACACTCTTCCAGCGGA
GACATTTGGACCTTGTTGGGAACAGTGCTTTATCCATTCCTTGCCATCTGGAGATTAATTAGCAATTTCTTGTTTAGTAATCCGCCTCCC
ACACAGACTTCAGTGAGAGTAACATCGTCAGAACCCCCAAACCCTGCATCATCTAGCAAATCAGAAAAAAGGGAACCAGTGAGAAAAAGA
GTGCTGGAAAAACGTGGAGACGACTTTAAAAAGGAGGGGAAAATTTATAGATTAAGGACTCAAGATGATGGTGAAGATGAAAACAACACT
TGGAATGGAAATTCCACTCAACAGATGTAGTGTGACAAGTATAATATGTGCAATAATCATTGTTTCTCTTATGATTTAATTCAACTAAAA
TTCTACTGGAGAAGTGGGACTGCTTTATATTTTCCAACTGGTCTATAAAATGTCTCTTTATTCCTGCTTAGTGGGTGTGGGTTGAAGGTG
TTTAACTCAGAAAAGTAAAGACAGGAAATAACTCTCTGCTAGGTCCTTGCTTATATGGCAACCACTGCTAGAACCCTAAAAGAACCAAAA
ATCTGCCACAGCCTGCCTCCATCAGCTTCTTATTTAGTATTTCATATGCCCATTAGCCCTATGCTTCAGATGACACGTTTTGTTTAGAGC
TACTTTGCTCCAAGACTCTTAAGCCCAAAGTAACTGGTATGTCACTGAGTAACTTGACTCGGTGTCAGAGCATTTTAACTAGCCACTCAG
ATGAGAATTTATGTTTAACTTCTCTTTTTACTCATCAGCTGCAAGCAAAATCTTGTAGTTTTTAATCTTAAACACTGAATAAAAAAACTT
TCCCCTAAATTGGAATGATCTTAGTTTTGCTTTGAGTTTTGTTATCTAGCATCTTTTTGTTGCACAGGGCTCTATTGAGGTCCTATGTCT
CTGATTTTTTTTTTTCCCCAGTATTGCCCTGGAGCTGTCTCTGGAAAGTAGCTGGCGAGGTTACCTTAACTATCACTGAAGAAAGAAATT
TTCTGACACACTGATGGCATGTGACTTGTCTCCTAAGTCAGTGAGGCATCACTTTGTTTGCATAAAGTATACGGTTTGTTAAGGCCTTTG
TTCTTGTGAGATGCAAAACAGCTGCTAGTCTGCAACCTAGTTTTCCCTCTCACCTTTAACTGACGTTTTGTCCTCAATAATTACACAAGG
ACCTAGAGTACCTATAGGACAAAAAGTATAGAATAAAAATATGCCTTTAGTCATTTGGTTTTTCTTAAAAAGTTGAGATTCTTAATCTGA
CTTACATGTTACTTTATCCGTATGTCTTTGTTAGTGGAGACCGCTAAACTAATGATGTTTGAAAACAGTTCCTCTGTTTTAGATTGGAAG
ATAGCACTCTAGAGTGGACATACGGAAAGACTGTGACTTTATTTTGTAATGGGAGGAAGAAATTTTCTCAGAGCAAACTTTCTATTTTTT
ACCTGTGAAATAACAGTGACTTTTTAAAATGGTGACAGTGTTGGCAAGGAAACAGCAACACAGGCTGCGCTGTTGGTAGGAGTGAAAACC
AGTATAATTCTTCTGAAAAACATTTATCAGAAACTTAAAATATTTCATACCGTTTGATCCAGTAGCTTCTTCTAAATCATAAATGCAGAC
AATGTTTAGGTAAAGACATACTCATTAAGTGTTATTTATTTTACTCAAGAACTGGAAACCAACTAAATGCCTTCTATAGAAGTAATTTTT
GATGAGGAGAAATGGTACAATACTAATTAACAACTTGGTTTAACATGTTTACTGAGCATCTGTTAAGTGTTGGGGGAAAAAGCAGCAGGA
TCCAGAGCTATAGGTACAGTGTGATCTCAGCTTTGCAAACACATTTTCTACATAGATAGTACTAGGTATTAATAGATATGTAAAGAAAGA
AATCACACCATTAATAATGGTAAGATTGGTTTATGTGATTTTAGTGGTATTTTTGGCACCCTTATATATGTTTTCCAAACTTTCAGCAGT
GATATTATTTCCATAACTTAAAAAGTGAGTTTGAAAAAGAAAATCTCCAGCAAGCATCTCATTTAAATAAAGGTTTGTCATCTTTAAAAA
TACAGCAATATGTGACTTTTTAAAAAAGCTGTCAAATAGGTGTGACCCTACTAATAATTATTAGAAATACATTTAAAAACATCGAGTACC
TCAAGTCAGTTTGCCTTGAAAAATATCAAATATAACTCTTAGAGAAATGTACATAAAAGAATGCTTCGTAATTTTGGAGTAGGAGGTTCC
CTCCTCAATTTTGTATTTTTAAAAGTACATGGTAAAAAAAAAAATTCACAACAGTATATAAGGCTGTAAAATGAGAATTCTGCCCCCTCA
CCTCTTACCCCAGTACTATTCTCCAGAGGTAATCTATTAACAATTTCTTATGTAATTTTCAGAAAATTTGTATGCGTATATAAGCAAATA

>100660_100660_2_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000373714_UBXN4_chr2_136505837_ENST00000272638_length(amino acids)=558AA_BP=77
MRVLTARGGRRAPSPQLWTLVLALIEEKWRSHRILRMNSGRPETMENLPALYTIFQGEVAMVTDYGAFIKIPGCRKQGDDEQSTQMAASW
EDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESS
VSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQR
EIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRE
SYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPT
ASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQ

--------------------------------------------------------------
>100660_100660_3_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000422613_UBXN4_chr2_136505837_ENST00000272638_length(transcript)=3711nt_BP=98nt
AGTTCAGCGCAGCGACTCGGGGACCTGGAGCTGACGCCTAGTTGCTATGGTGACAGACTATGGGGCCTTTATCAAAATCCCAGGCTGTCG
GAAGCAAGGTGATGATGAACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAGAAGCATCTTCAAACAGTTTTGTTGC
TATTAAAATCGATACCAAAAGTGAAGCCTGCCTACAGTTTTCACAAATCTATCCTGTAGTGTGTGTTCCATCCAGTTTCTTTATTGGAGA
CAGTGGAATTCCCTTGGAAGTAATAGCAGGAAGTGTTTCTGCAGATGAACTTGTTACAAGAATTCACAAGGTCCGACAGATGCATTTGCT
AAAAAGTGAAACATCAGTAGCAAATGGCAGTCAGTCAGAAAGTTCAGTGTCTACTCCATCTGCGTCATTTGAACCTAACAACACTTGTGA
AAACTCTCAGTCCAGAAATGCAGAGCTTTGTGAGATACCACCCACTTCTGATACAAAGTCAGATACTGCAACAGGAGGAGAAAGTGCAGG
CCATGCCACTTCCTCTCAGGAGCCTAGTGGATGCTCAGATCAGAGACCTGCAGAGGACCTCAACATCCGAGTGGAAAGACTAACAAAAAA
ACTTGAAGAAAGGAGAGAAGAGAAAAGAAAAGAGGAAGAACAGAGAGAAATTAAGAAGGAAATTGAGAGGAGAAAAACTGGAAAAGAAAT
GTTGGATTATAAAAGAAAACAAGAAGAAGAATTAACAAAAAGAATGCTGGAGGAAAGAAACAGAGAGAAAGCAGAAGATAGGGCAGCTCG
AGAACGTATAAAACAGCAGATTGCATTGGACCGTGCAGAGAGAGCTGCTCGTTTTGCAAAGACAAAGGAAGAAGTAGAGGCTGCCAAAGC
TGCTGCCTTGCTAGCAAAACAGGCAGAAATGGAAGTCAAGAGGGAATCTTATGCAAGAGAAAGAAGCACTGTTGCAAGAATTCAATTCCG
TCTTCCTGATGGTTCTTCCTTTACAAATCAGTTCCCTTCTGATGCTCCTCTAGAAGAGGCAAGGCAGTTTGCTGCACAGACTGTTGGCAA
CACTTACGGTAATTTTTCGTTAGCAACCATGTTTCCCAGGAGGGAATTTACCAAAGAAGATTATAAAAAGAAGTTACTGGATTTGGAACT
TGCCCCAAGCGCTTCGGTGGTACTGTTGCCAGCAGGAAGACCAACTGCATCCATTGTACACTCTTCCAGCGGAGACATTTGGACCTTGTT
GGGAACAGTGCTTTATCCATTCCTTGCCATCTGGAGATTAATTAGCAATTTCTTGTTTAGTAATCCGCCTCCCACACAGACTTCAGTGAG
AGTAACATCGTCAGAACCCCCAAACCCTGCATCATCTAGCAAATCAGAAAAAAGGGAACCAGTGAGAAAAAGAGTGCTGGAAAAACGTGG
AGACGACTTTAAAAAGGAGGGGAAAATTTATAGATTAAGGACTCAAGATGATGGTGAAGATGAAAACAACACTTGGAATGGAAATTCCAC
TCAACAGATGTAGTGTGACAAGTATAATATGTGCAATAATCATTGTTTCTCTTATGATTTAATTCAACTAAAATTCTACTGGAGAAGTGG
GACTGCTTTATATTTTCCAACTGGTCTATAAAATGTCTCTTTATTCCTGCTTAGTGGGTGTGGGTTGAAGGTGTTTAACTCAGAAAAGTA
AAGACAGGAAATAACTCTCTGCTAGGTCCTTGCTTATATGGCAACCACTGCTAGAACCCTAAAAGAACCAAAAATCTGCCACAGCCTGCC
TCCATCAGCTTCTTATTTAGTATTTCATATGCCCATTAGCCCTATGCTTCAGATGACACGTTTTGTTTAGAGCTACTTTGCTCCAAGACT
CTTAAGCCCAAAGTAACTGGTATGTCACTGAGTAACTTGACTCGGTGTCAGAGCATTTTAACTAGCCACTCAGATGAGAATTTATGTTTA
ACTTCTCTTTTTACTCATCAGCTGCAAGCAAAATCTTGTAGTTTTTAATCTTAAACACTGAATAAAAAAACTTTCCCCTAAATTGGAATG
ATCTTAGTTTTGCTTTGAGTTTTGTTATCTAGCATCTTTTTGTTGCACAGGGCTCTATTGAGGTCCTATGTCTCTGATTTTTTTTTTTCC
CCAGTATTGCCCTGGAGCTGTCTCTGGAAAGTAGCTGGCGAGGTTACCTTAACTATCACTGAAGAAAGAAATTTTCTGACACACTGATGG
CATGTGACTTGTCTCCTAAGTCAGTGAGGCATCACTTTGTTTGCATAAAGTATACGGTTTGTTAAGGCCTTTGTTCTTGTGAGATGCAAA
ACAGCTGCTAGTCTGCAACCTAGTTTTCCCTCTCACCTTTAACTGACGTTTTGTCCTCAATAATTACACAAGGACCTAGAGTACCTATAG
GACAAAAAGTATAGAATAAAAATATGCCTTTAGTCATTTGGTTTTTCTTAAAAAGTTGAGATTCTTAATCTGACTTACATGTTACTTTAT
CCGTATGTCTTTGTTAGTGGAGACCGCTAAACTAATGATGTTTGAAAACAGTTCCTCTGTTTTAGATTGGAAGATAGCACTCTAGAGTGG
ACATACGGAAAGACTGTGACTTTATTTTGTAATGGGAGGAAGAAATTTTCTCAGAGCAAACTTTCTATTTTTTACCTGTGAAATAACAGT
GACTTTTTAAAATGGTGACAGTGTTGGCAAGGAAACAGCAACACAGGCTGCGCTGTTGGTAGGAGTGAAAACCAGTATAATTCTTCTGAA
AAACATTTATCAGAAACTTAAAATATTTCATACCGTTTGATCCAGTAGCTTCTTCTAAATCATAAATGCAGACAATGTTTAGGTAAAGAC
ATACTCATTAAGTGTTATTTATTTTACTCAAGAACTGGAAACCAACTAAATGCCTTCTATAGAAGTAATTTTTGATGAGGAGAAATGGTA
CAATACTAATTAACAACTTGGTTTAACATGTTTACTGAGCATCTGTTAAGTGTTGGGGGAAAAAGCAGCAGGATCCAGAGCTATAGGTAC
AGTGTGATCTCAGCTTTGCAAACACATTTTCTACATAGATAGTACTAGGTATTAATAGATATGTAAAGAAAGAAATCACACCATTAATAA
TGGTAAGATTGGTTTATGTGATTTTAGTGGTATTTTTGGCACCCTTATATATGTTTTCCAAACTTTCAGCAGTGATATTATTTCCATAAC
TTAAAAAGTGAGTTTGAAAAAGAAAATCTCCAGCAAGCATCTCATTTAAATAAAGGTTTGTCATCTTTAAAAATACAGCAATATGTGACT
TTTTAAAAAAGCTGTCAAATAGGTGTGACCCTACTAATAATTATTAGAAATACATTTAAAAACATCGAGTACCTCAAGTCAGTTTGCCTT
GAAAAATATCAAATATAACTCTTAGAGAAATGTACATAAAAGAATGCTTCGTAATTTTGGAGTAGGAGGTTCCCTCCTCAATTTTGTATT
TTTAAAAGTACATGGTAAAAAAAAAAATTCACAACAGTATATAAGGCTGTAAAATGAGAATTCTGCCCCCTCACCTCTTACCCCAGTACT
ATTCTCCAGAGGTAATCTATTAACAATTTCTTATGTAATTTTCAGAAAATTTGTATGCGTATATAAGCAAATATGTAATCTTTATTTTTT

>100660_100660_3_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000422613_UBXN4_chr2_136505837_ENST00000272638_length(amino acids)=498AA_BP=17
MVTDYGAFIKIPGCRKQGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSAD
ELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQR
PAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERA
ARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRRE
FTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKS

--------------------------------------------------------------
>100660_100660_4_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000546109_UBXN4_chr2_136505837_ENST00000272638_length(transcript)=3906nt_BP=293nt
GTTTAGTTCAGCGCAGCGACTCGGGGACCTGGAGCTGACGCCTAGACACTTGTATTAGCTTTAATAGAAGAGAAATGGAGGAGCCATAGA
ATATTAAGGATGAATTCAGGAAGGCCTGAGACCATGGAAAACTTGCCTGCTCTCTACACTATTTTCCAAGGAGAGTTATGGTGAAGCTGA
AACAGTGCTCAAGATGAAGCAGCTAATTGAAGACACTGAAAAGAATAAAGTTTATGTTGCTATGGTGACAGACTATGGGGCCTTTATCAA
AATCCCAGGCTGTCGGAAGCAAGGTGATGATGAACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAGAAGCATCTTC
AAACAGTTTTGTTGCTATTAAAATCGATACCAAAAGTGAAGCCTGCCTACAGTTTTCACAAATCTATCCTGTAGTGTGTGTTCCATCCAG
TTTCTTTATTGGAGACAGTGGAATTCCCTTGGAAGTAATAGCAGGAAGTGTTTCTGCAGATGAACTTGTTACAAGAATTCACAAGGTCCG
ACAGATGCATTTGCTAAAAAGTGAAACATCAGTAGCAAATGGCAGTCAGTCAGAAAGTTCAGTGTCTACTCCATCTGCGTCATTTGAACC
TAACAACACTTGTGAAAACTCTCAGTCCAGAAATGCAGAGCTTTGTGAGATACCACCCACTTCTGATACAAAGTCAGATACTGCAACAGG
AGGAGAAAGTGCAGGCCATGCCACTTCCTCTCAGGAGCCTAGTGGATGCTCAGATCAGAGACCTGCAGAGGACCTCAACATCCGAGTGGA
AAGACTAACAAAAAAACTTGAAGAAAGGAGAGAAGAGAAAAGAAAAGAGGAAGAACAGAGAGAAATTAAGAAGGAAATTGAGAGGAGAAA
AACTGGAAAAGAAATGTTGGATTATAAAAGAAAACAAGAAGAAGAATTAACAAAAAGAATGCTGGAGGAAAGAAACAGAGAGAAAGCAGA
AGATAGGGCAGCTCGAGAACGTATAAAACAGCAGATTGCATTGGACCGTGCAGAGAGAGCTGCTCGTTTTGCAAAGACAAAGGAAGAAGT
AGAGGCTGCCAAAGCTGCTGCCTTGCTAGCAAAACAGGCAGAAATGGAAGTCAAGAGGGAATCTTATGCAAGAGAAAGAAGCACTGTTGC
AAGAATTCAATTCCGTCTTCCTGATGGTTCTTCCTTTACAAATCAGTTCCCTTCTGATGCTCCTCTAGAAGAGGCAAGGCAGTTTGCTGC
ACAGACTGTTGGCAACACTTACGGTAATTTTTCGTTAGCAACCATGTTTCCCAGGAGGGAATTTACCAAAGAAGATTATAAAAAGAAGTT
ACTGGATTTGGAACTTGCCCCAAGCGCTTCGGTGGTACTGTTGCCAGCAGGAAGACCAACTGCATCCATTGTACACTCTTCCAGCGGAGA
CATTTGGACCTTGTTGGGAACAGTGCTTTATCCATTCCTTGCCATCTGGAGATTAATTAGCAATTTCTTGTTTAGTAATCCGCCTCCCAC
ACAGACTTCAGTGAGAGTAACATCGTCAGAACCCCCAAACCCTGCATCATCTAGCAAATCAGAAAAAAGGGAACCAGTGAGAAAAAGAGT
GCTGGAAAAACGTGGAGACGACTTTAAAAAGGAGGGGAAAATTTATAGATTAAGGACTCAAGATGATGGTGAAGATGAAAACAACACTTG
GAATGGAAATTCCACTCAACAGATGTAGTGTGACAAGTATAATATGTGCAATAATCATTGTTTCTCTTATGATTTAATTCAACTAAAATT
CTACTGGAGAAGTGGGACTGCTTTATATTTTCCAACTGGTCTATAAAATGTCTCTTTATTCCTGCTTAGTGGGTGTGGGTTGAAGGTGTT
TAACTCAGAAAAGTAAAGACAGGAAATAACTCTCTGCTAGGTCCTTGCTTATATGGCAACCACTGCTAGAACCCTAAAAGAACCAAAAAT
CTGCCACAGCCTGCCTCCATCAGCTTCTTATTTAGTATTTCATATGCCCATTAGCCCTATGCTTCAGATGACACGTTTTGTTTAGAGCTA
CTTTGCTCCAAGACTCTTAAGCCCAAAGTAACTGGTATGTCACTGAGTAACTTGACTCGGTGTCAGAGCATTTTAACTAGCCACTCAGAT
GAGAATTTATGTTTAACTTCTCTTTTTACTCATCAGCTGCAAGCAAAATCTTGTAGTTTTTAATCTTAAACACTGAATAAAAAAACTTTC
CCCTAAATTGGAATGATCTTAGTTTTGCTTTGAGTTTTGTTATCTAGCATCTTTTTGTTGCACAGGGCTCTATTGAGGTCCTATGTCTCT
GATTTTTTTTTTTCCCCAGTATTGCCCTGGAGCTGTCTCTGGAAAGTAGCTGGCGAGGTTACCTTAACTATCACTGAAGAAAGAAATTTT
CTGACACACTGATGGCATGTGACTTGTCTCCTAAGTCAGTGAGGCATCACTTTGTTTGCATAAAGTATACGGTTTGTTAAGGCCTTTGTT
CTTGTGAGATGCAAAACAGCTGCTAGTCTGCAACCTAGTTTTCCCTCTCACCTTTAACTGACGTTTTGTCCTCAATAATTACACAAGGAC
CTAGAGTACCTATAGGACAAAAAGTATAGAATAAAAATATGCCTTTAGTCATTTGGTTTTTCTTAAAAAGTTGAGATTCTTAATCTGACT
TACATGTTACTTTATCCGTATGTCTTTGTTAGTGGAGACCGCTAAACTAATGATGTTTGAAAACAGTTCCTCTGTTTTAGATTGGAAGAT
AGCACTCTAGAGTGGACATACGGAAAGACTGTGACTTTATTTTGTAATGGGAGGAAGAAATTTTCTCAGAGCAAACTTTCTATTTTTTAC
CTGTGAAATAACAGTGACTTTTTAAAATGGTGACAGTGTTGGCAAGGAAACAGCAACACAGGCTGCGCTGTTGGTAGGAGTGAAAACCAG
TATAATTCTTCTGAAAAACATTTATCAGAAACTTAAAATATTTCATACCGTTTGATCCAGTAGCTTCTTCTAAATCATAAATGCAGACAA
TGTTTAGGTAAAGACATACTCATTAAGTGTTATTTATTTTACTCAAGAACTGGAAACCAACTAAATGCCTTCTATAGAAGTAATTTTTGA
TGAGGAGAAATGGTACAATACTAATTAACAACTTGGTTTAACATGTTTACTGAGCATCTGTTAAGTGTTGGGGGAAAAAGCAGCAGGATC
CAGAGCTATAGGTACAGTGTGATCTCAGCTTTGCAAACACATTTTCTACATAGATAGTACTAGGTATTAATAGATATGTAAAGAAAGAAA
TCACACCATTAATAATGGTAAGATTGGTTTATGTGATTTTAGTGGTATTTTTGGCACCCTTATATATGTTTTCCAAACTTTCAGCAGTGA
TATTATTTCCATAACTTAAAAAGTGAGTTTGAAAAAGAAAATCTCCAGCAAGCATCTCATTTAAATAAAGGTTTGTCATCTTTAAAAATA
CAGCAATATGTGACTTTTTAAAAAAGCTGTCAAATAGGTGTGACCCTACTAATAATTATTAGAAATACATTTAAAAACATCGAGTACCTC
AAGTCAGTTTGCCTTGAAAAATATCAAATATAACTCTTAGAGAAATGTACATAAAAGAATGCTTCGTAATTTTGGAGTAGGAGGTTCCCT
CCTCAATTTTGTATTTTTAAAAGTACATGGTAAAAAAAAAAATTCACAACAGTATATAAGGCTGTAAAATGAGAATTCTGCCCCCTCACC
TCTTACCCCAGTACTATTCTCCAGAGGTAATCTATTAACAATTTCTTATGTAATTTTCAGAAAATTTGTATGCGTATATAAGCAAATATG

>100660_100660_4_ZCCHC17-UBXN4_ZCCHC17_chr1_31792013_ENST00000546109_UBXN4_chr2_136505837_ENST00000272638_length(amino acids)=540AA_BP=59
MRPWKTCLLSTLFSKESYGEAETVLKMKQLIEDTEKNKVYVAMVTDYGAFIKIPGCRKQGDDEQSTQMAASWEDDKVTEASSNSFVAIKI
DTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQ
SRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDY
KRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPD
GSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTV
LYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZCCHC17-UBXN4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	UBXN4	chr1:31792013	chr2:136505837	ENST00000272638		0	13	1_200	27.333333333333332	509.0	UBQLN1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZCCHC17-UBXN4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZCCHC17-UBXN4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source