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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZCCHC2-KIAA1468 (FusionGDB2 ID:100668)

Fusion Gene Summary for ZCCHC2-KIAA1468

check button Fusion gene summary
Fusion gene informationFusion gene name: ZCCHC2-KIAA1468
Fusion gene ID: 100668
HgeneTgene
Gene symbol

ZCCHC2

KIAA1468

Gene ID

54877

57614

Gene namezinc finger CCHC-type containing 2RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
SynonymsC18orf49HsT3308|HsT885|KIAA1468
Cytomap

18q21.33

18q21.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCHC domain-containing protein 2zinc finger, CCHC domain containing 2RAB11-binding protein RELCHRAB11-binding protein containing LisH, coiled-coil, and HEAT repeats
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269499, ENST00000586834, 
ENST00000590840, 		ENST00000592479, 
ENST00000256858, ENST00000398130, 
Fusion gene scores* DoF score8 X 7 X 5=2804 X 4 X 5=80
# samples 85
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZCCHC2 [Title/Abstract] AND KIAA1468 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZCCHC2(60232329)-KIAA1468(59936101), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIAA1468

GO:0032367

intracellular cholesterol transport

29514919


check buttonFusion gene breakpoints across ZCCHC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIAA1468 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-FI-A2EUZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+


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Fusion Gene ORF analysis for ZCCHC2-KIAA1468

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000269499ENST00000592479ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
5CDS-intronENST00000586834ENST00000592479ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
In-frameENST00000269499ENST00000256858ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
In-frameENST00000269499ENST00000398130ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
In-frameENST00000586834ENST00000256858ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
In-frameENST00000586834ENST00000398130ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
intron-3CDSENST00000590840ENST00000256858ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
intron-3CDSENST00000590840ENST00000398130ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+
intron-intronENST00000590840ENST00000592479ZCCHC2chr18

60232329

+KIAA1468chr18

59936101

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269499ZCCHC2chr1860232329+ENST00000256858KIAA1468chr1859936101+491522644183336972
ENST00000269499ZCCHC2chr1860232329+ENST00000398130KIAA1468chr1859936101+482322644183234938
ENST00000586834ZCCHC2chr1860232329+ENST00000256858KIAA1468chr1859936101+372510741912146651
ENST00000586834ZCCHC2chr1860232329+ENST00000398130KIAA1468chr1859936101+363310741912044617

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000269499ENST00000256858ZCCHC2chr1860232329+KIAA1468chr1859936101+0.0002596920.9997403
ENST00000269499ENST00000398130ZCCHC2chr1860232329+KIAA1468chr1859936101+0.0002517020.9997483
ENST00000586834ENST00000256858ZCCHC2chr1860232329+KIAA1468chr1859936101+0.0002817180.99971825
ENST00000586834ENST00000398130ZCCHC2chr1860232329+KIAA1468chr1859936101+0.0003209690.9996791

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Fusion Genomic Features for ZCCHC2-KIAA1468


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZCCHC2chr1860232329+KIAA1468chr1859936101+0.051732510.9482675
ZCCHC2chr1860232329+KIAA1468chr1859936101+0.051732510.9482675

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZCCHC2-KIAA1468


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:60232329/chr18:59936101)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZCCHC2chr18:60232329chr18:59936101ENST00000269499+11147_706151179.0Compositional biasNote=Pro-rich
TgeneKIAA1468chr18:60232329chr18:59936101ENST0000025685818301004_10428931251.0RepeatHEAT 3
TgeneKIAA1468chr18:60232329chr18:59936101ENST0000039813018291004_10428931217.0RepeatHEAT 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZCCHC2chr18:60232329chr18:59936101ENST00000269499+11141131_11486151179.0Zinc fingerCCHC-type
TgeneKIAA1468chr18:60232329chr18:59936101ENST000002568581830197_2318931251.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1468chr18:60232329chr18:59936101ENST000002568581830359_3978931251.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1468chr18:60232329chr18:59936101ENST000003981301829197_2318931217.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1468chr18:60232329chr18:59936101ENST000003981301829359_3978931217.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1468chr18:60232329chr18:59936101ENST000002568581830255_2878931251.0DomainLisH
TgeneKIAA1468chr18:60232329chr18:59936101ENST000003981301829255_2878931217.0DomainLisH
TgeneKIAA1468chr18:60232329chr18:59936101ENST000002568581830601_6398931251.0RepeatHEAT 1
TgeneKIAA1468chr18:60232329chr18:59936101ENST000002568581830640_6798931251.0RepeatHEAT 2
TgeneKIAA1468chr18:60232329chr18:59936101ENST000003981301829601_6398931217.0RepeatHEAT 1
TgeneKIAA1468chr18:60232329chr18:59936101ENST000003981301829640_6798931217.0RepeatHEAT 2


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Fusion Gene Sequence for ZCCHC2-KIAA1468


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100668_100668_1_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000269499_KIAA1468_chr18_59936101_ENST00000256858_length(transcript)=4915nt_BP=2264nt
GCCCGGCCCGGCTGCTCCACCTCCTCACCCAGCCGCTCCGTCCTCACCGGCTCGCGAGGGAACAGCTCAGGCACCGCCGCCCCGGCTCAG
CGCGGACGGCGGAGAGAGGGAGGCGGAAGGAGGACACCCTCGCTCGCTTGCTCCCACCCGCACCCGGGCTCCCAGAACCGGCGAGGAGCC
CAGGGGGAGGAGCCGTCGCGGGCACGCCCCGCCCCCAGCCCGGGAAGACGACGCCAGCGACCCCGCCGGCCGGCCACCGCCCCCCTCGCC
GGCCGAGACCCGCCCCCGGCCCCGGCCCTCCCCCGGCGGCATGGAGGGGCCCCGCTCCTGACGGCCGCGCCGCCGCCTCGGCCCGTGCTC
CACCTCGCGGCCCCTCCCGCCCGCCCCCGCTCGCATGTCTGCGCCGCCCTAGCCGAGGATGCTGAGGATGAAGCTGCCGCTGAAGCCAAC
GCACCCCGCGGAGCCGCCGCCCGAGGCGGAGGAGCCCGAGGCGGACGCGCGGCCGGGCGCGAAGGCGCCTTCGCGCCGCCGCCGCGACTG
CCGCCCCCCGCCGCCGCCGCCGCCGCCCGCGGGCCCGTCGCGGGGCCCTCTGCCGCCGCCGCCGCCGCCCCGGGGACTCGGGCCGCCTGT
TGCTGGTGGAGCGGCGGCGGGGGCGGGTATGCCGGGCGGCGGCGGGGGGCCCTCGGCGGCGCTGCGCGAGCAGGAGCGGGTATACGAGTG
GTTCGGGCTGGTGCTGGGCTCGGCGCAGCGCCTGGAGTTCATGTGCGGGCTGCTGGACCTGTGCAACCCGCTGGAGCTGCGCTTCCTTGG
CTCGTGCCTGGAGGACCTGGCGCGCAAGGACTACCACTACCTGCGCGACTCGGAGGCCAAGGCCAACGGCCTCTCGGACCCGGGGCCGCT
GGCCGACTTCCGAGAGCCCGCGGTGCGCTCGCGCCTCATCGTCTACCTGGCGCTGCTGGGCTCGGAGAACCGGGAGGCCGCTGGCCGTCT
GCACCGCCTGCTACCCCAGGTGGACTCGGTGCTCAAAAGCCTGCGCGCGGCCCGGGGCGAGGGCTCGCGGGGCGGCGCGGAGGACGAGCG
CGGCGAGGACGGCGACGGCGAGCAGGACGCCGAGAAGGACGGCTCAGGCCCGGAAGGCGGCATTGTGGAGCCCCGGGTCGGCGGCGGGCT
TGGCTCCAGGGCCCAGGAGGAACTGCTGCTGCTCTTCACCATGGCCTCGCTGCACCCGGCTTTCTCCTTCCACCAGCGGGTCACCCTGAG
GGAACACTTGGAGAGGCTCCGCGCCGCGCTCCGCGGGGGCCCCGAGGACGCGGAGGTGGAGGTAGAGCCGTGCAAGTTTGCCGGCCCCAG
GGCCCAGAACAACTCTGCTCATGGTGATTACATGCAAAATAACGAGAGCAGCTTAATAGAGCAAGCTCCAATACCTCAGGACGGACTTAC
CGTGGCACCTCACAGAGCTCAGCGAGAAGCTGTACACATTGAGAAGATAATGTTGAAAGGAGTCCAGAGAAAAAGAGCTGACAAATACTG
GGAGTACACTTTCAAAGTAAATTGGTCTGATCTTTCAGTCACAACAGTAACAAAAACCCACCAAGAACTACAGGAATTTCTACTGAAGCT
TCCAAAGGAACTGTCTTCAGAGACTTTTGACAAGACCATCTTAAGAGCCCTGAATCAGGGTTCCTTGAAAAGGGAGGAACGGCGACATCC
TGACCTAGAGCCCATCCTAAGGCAGCTATTTTCAAGTTCATCACAAGCTTTTCTACAAAGTCAGAAAGTACACAGCTTCTTTCAGTCCAT
ATCATCAGACTCCCTACACAGTATCAATAACTTACAATCCTCTCTGAAGACTTCTAAGATATTAGAACACTTAAAAGAAGACAGCTCTGA
AGCTTCAAGTCAAGAAGAAGATGTGTTGCAGCATGCCATAATCCACAAGAAGCATACTGGGAAAAGTCCCATTGTGAACAATATTGGTAC
AAGTTGTTCTCCATTGGATGGGCTTACCATGCAATATTCTGAACAGAATGGAATTGTGGATTGGAGGAAGCAAAGCTGTACCACCATTCA
ACACCCAGAGCACTGTGTGACCTCGGCTGACCAGCATTCTGCTGAAAAACGGAGTTTATCTTCAATAAATAAGAAGAAAGGAAAGCCACA
AACAGAAAAGGAGAAAATTAAGAAAACTGACAACAGATTGAATAGTAGAATAAATGGTATTAGACTCTCCACTCCTCAGCATGCCCATGG
TGGTACTGTGAAAGATTCCTCAGCAGGAAATGGGGTCCTCACTAAAGCTACAGTCCCCATTTATGCAACAGGAGTCCTTACGTGTTATAT
TCAGATAAAGGAGTATTTGCATATACATAATGAGATATCTTGGGAATGGGACCCAAGTCTAAACACAAAATGTGTTTCATATACACATTA
TACACATAGCCTGAAGGAAGAAGACCGAAAACTGTTAGTTGGATTCTTAGAAGATGTAATGACGCTGCTTTCATTATCTCATGCTCCTCT
TGATAGCCTGAAGGCTTCTTTTGTGGAATTGGGTGCAAACCCAGCCTACCATGAGTTACTATTAACTGTTTTGTGGTATGGTGTTGTCCA
TACTTCAGCACTCGTGAGGTGTACTGCTGCTAGAATGTTTGAGCTGTTGGTGAAGGGGGTGAATGAAACTCTGGTAGCTCAGAGGGTTGT
TCCTGCTCTCATTACTCTCTCCAGTGACCCTGAAATCTCTGTCAGGATTGCCACAATTCCAGCCTTTGGCACTATTATGGAAACAGTAAT
TCAAAGAGAGTTGCTGGAAAGAGTGAAAATGCAGTTGGCTTCTTTCCTGGAAGATCCTCAGTATCAAGACCAACATTCTTTGCATACAGA
GATCATAAAAACATTTGGTAGAGTTGGCCCTAACGCAGAACCCAGGTTCCGAGATGAGTTTGTTATACCACATTTGCATAAGTTAGCCTT
GGTGAACAACTTACAGATTGTGGATTCTAAAAGACTGGACATTGCTACGCATCTTTTTGAAGCCTACAGTGCACTTTCCTGTTGTTTCAT
TTCAGAGGATTTAATGGTTAATCACTTTTTACCTGGTCTCAGATGTTTACGGACTGACATGGAACATCTCTCTCCAGAGCATGAGGTTAT
TTTAAGTTCCATGATAAAAGAATGTGAACAAAAAGTTGAAAACAAGACCGTCCAAGAGCCTCAAGGCTCAATGTCAATTGCTGCAAGCTT
AGTGAGTGAAGATACAAAGACCAAGTTTTTGAACAAAATGGGCCAGTTGACAACATCAGGTGCCATGTTGGCCAATGTATTTCAGAGAAA
GAAGTAGAAGCAGGAAAGAAGCCCCCAGTAAACACTAAGATGGACCTCAAGCCGACTGGTTCCTTGTACTTGAAGTACTTGCCTTTTTTG
TTTCCTCAGTTTTATGTTCTTGCATTATAATTTTATCCTAACCTCCAAAGATATTTGCACTGCTTTTAATTACTGCTGTATATTTGTTGA
TTTTGGAGTTACAACTGTGGTGATAGAAAATTGAGTTGATGGTCTGTACCAAGTCCCTTGTCTATGTTCTTGTCTTTCAGAATAATTTTT
ATATAAATATATATATAGTGAAGAAGTTTTTTTTAATTTTTGGATGGGATATTCGCAAATATCTGTATTATACACTAAGCTATTACAATG
GTACTTAAAATAATGTAAATTTGAAGTCATTGTTATAAAATAATAAAGTGGAGATTACTTAAGTATTTAAATTATGAAAGAATAATGCAG
ACTTTTTATTGTTTCTTAACTGACTAGAAAGAGCCACCAGCATTACTCTGTGCCTTTTGGACATCAGTTTGTGTGTTCTGTAGGAATTGT
GTGCATTCCATTCACACAGTATTTCTTTAGGATGCTGTGATGATTTGAATTACAAATCCTACAGTCAATAGCTAAAGACGAAACCTTCAT
TTCAGAACTCTCATGAATATTCTTTAAGTGCTATTTAAACCTCCCCAGCACTTAGATGCATATAATGGACTTACCTGAGGAAAGACAGCA
CATAGGCATGGGGAGAGGTAACCAAGGTGAATTTTACAAACTGGTGTATAGTAGATTTAAATGCTCAAAAATAAATGTAACTGAGAAGAG
TTAATAATTGTGAGATTTTTCCCAAATTGAGATACAGAAGAAAATATAGTTTGAATCTGAAATTTAACACTTATTTATGTAAAACACTTT
ATTTAAGATATTTTCTAATGATTTTAATTTTAGAGAGTACCTTTTCATTCTGTGTGTTACAGAGAAGTACTGAAAAGTTAAGGACACTTG
GGGGCTACTTTTTTCCCTCTAAACTAAAAAAGACATTGGCTGAATTATAACTAGTTAGTTATCACCTCGTCCCTTAAAGTCAGTGACCTC
CTGTGTTTGATGTATATTACATAGAGTCTTAAGTCAGTGTACAGTTCCACTGGAATTTGACAGTTGTCTCTACAGTCATGCAACTCGAAG
TAGAAAAGAGTGCTGGACATAGGAAGGGGGTGCTTGGTTTGAGGGGTTAATGTGAGGCCTTTTTGAAAAATGAATATTTTGATAAAAAGA
ATTCTTGTTTTAGCACAGTTGATGCACATAAGTGATTCTCATATTTGTTGTATAAACTGGTTTAATACATTTGGAACATAGTTGGATTAC
ATTCATTTCCTGGGAAAGCTAGCTTACCATACATTCAAGTTTATAAAACAATTTGCCATAGGCAAAGCCATTTAAAAAGTTCATTCTGAA
ATTATTTCATTTACCTACAGTGAAATAATTGTGAACTAAGTAGTCTTTCTGAAAACTGTTGGGTTCTAGGCATTCCTGAGAAATTGAAAG

>100668_100668_1_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000269499_KIAA1468_chr18_59936101_ENST00000256858_length(amino acids)=972AA_BP=615
MLRMKLPLKPTHPAEPPPEAEEPEADARPGAKAPSRRRRDCRPPPPPPPPAGPSRGPLPPPPPPRGLGPPVAGGAAAGAGMPGGGGGPSA
ALREQERVYEWFGLVLGSAQRLEFMCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGPLADFREPAVRSRLIVYLALL
GSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRGGAEDERGEDGDGEQDAEKDGSGPEGGIVEPRVGGGLGSRAQEELLLLFTMASLHP
AFSFHQRVTLREHLERLRAALRGGPEDAEVEVEPCKFAGPRAQNNSAHGDYMQNNESSLIEQAPIPQDGLTVAPHRAQREAVHIEKIMLK
GVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKELSSETFDKTILRALNQGSLKREERRHPDLEPILRQLFSSSSQAFLQ
SQKVHSFFQSISSDSLHSINNLQSSLKTSKILEHLKEDSSEASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIV
DWRKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHAHGGTVKDSSAGNGVLTKATVP
IYATGVLTCYIQIKEYLHIHNEISWEWDPSLNTKCVSYTHYTHSLKEEDRKLLVGFLEDVMTLLSLSHAPLDSLKASFVELGANPAYHEL
LLTVLWYGVVHTSALVRCTAARMFELLVKGVNETLVAQRVVPALITLSSDPEISVRIATIPAFGTIMETVIQRELLERVKMQLASFLEDP
QYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIPHLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGLRCLRTD

--------------------------------------------------------------
>100668_100668_2_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000269499_KIAA1468_chr18_59936101_ENST00000398130_length(transcript)=4823nt_BP=2264nt
GCCCGGCCCGGCTGCTCCACCTCCTCACCCAGCCGCTCCGTCCTCACCGGCTCGCGAGGGAACAGCTCAGGCACCGCCGCCCCGGCTCAG
CGCGGACGGCGGAGAGAGGGAGGCGGAAGGAGGACACCCTCGCTCGCTTGCTCCCACCCGCACCCGGGCTCCCAGAACCGGCGAGGAGCC
CAGGGGGAGGAGCCGTCGCGGGCACGCCCCGCCCCCAGCCCGGGAAGACGACGCCAGCGACCCCGCCGGCCGGCCACCGCCCCCCTCGCC
GGCCGAGACCCGCCCCCGGCCCCGGCCCTCCCCCGGCGGCATGGAGGGGCCCCGCTCCTGACGGCCGCGCCGCCGCCTCGGCCCGTGCTC
CACCTCGCGGCCCCTCCCGCCCGCCCCCGCTCGCATGTCTGCGCCGCCCTAGCCGAGGATGCTGAGGATGAAGCTGCCGCTGAAGCCAAC
GCACCCCGCGGAGCCGCCGCCCGAGGCGGAGGAGCCCGAGGCGGACGCGCGGCCGGGCGCGAAGGCGCCTTCGCGCCGCCGCCGCGACTG
CCGCCCCCCGCCGCCGCCGCCGCCGCCCGCGGGCCCGTCGCGGGGCCCTCTGCCGCCGCCGCCGCCGCCCCGGGGACTCGGGCCGCCTGT
TGCTGGTGGAGCGGCGGCGGGGGCGGGTATGCCGGGCGGCGGCGGGGGGCCCTCGGCGGCGCTGCGCGAGCAGGAGCGGGTATACGAGTG
GTTCGGGCTGGTGCTGGGCTCGGCGCAGCGCCTGGAGTTCATGTGCGGGCTGCTGGACCTGTGCAACCCGCTGGAGCTGCGCTTCCTTGG
CTCGTGCCTGGAGGACCTGGCGCGCAAGGACTACCACTACCTGCGCGACTCGGAGGCCAAGGCCAACGGCCTCTCGGACCCGGGGCCGCT
GGCCGACTTCCGAGAGCCCGCGGTGCGCTCGCGCCTCATCGTCTACCTGGCGCTGCTGGGCTCGGAGAACCGGGAGGCCGCTGGCCGTCT
GCACCGCCTGCTACCCCAGGTGGACTCGGTGCTCAAAAGCCTGCGCGCGGCCCGGGGCGAGGGCTCGCGGGGCGGCGCGGAGGACGAGCG
CGGCGAGGACGGCGACGGCGAGCAGGACGCCGAGAAGGACGGCTCAGGCCCGGAAGGCGGCATTGTGGAGCCCCGGGTCGGCGGCGGGCT
TGGCTCCAGGGCCCAGGAGGAACTGCTGCTGCTCTTCACCATGGCCTCGCTGCACCCGGCTTTCTCCTTCCACCAGCGGGTCACCCTGAG
GGAACACTTGGAGAGGCTCCGCGCCGCGCTCCGCGGGGGCCCCGAGGACGCGGAGGTGGAGGTAGAGCCGTGCAAGTTTGCCGGCCCCAG
GGCCCAGAACAACTCTGCTCATGGTGATTACATGCAAAATAACGAGAGCAGCTTAATAGAGCAAGCTCCAATACCTCAGGACGGACTTAC
CGTGGCACCTCACAGAGCTCAGCGAGAAGCTGTACACATTGAGAAGATAATGTTGAAAGGAGTCCAGAGAAAAAGAGCTGACAAATACTG
GGAGTACACTTTCAAAGTAAATTGGTCTGATCTTTCAGTCACAACAGTAACAAAAACCCACCAAGAACTACAGGAATTTCTACTGAAGCT
TCCAAAGGAACTGTCTTCAGAGACTTTTGACAAGACCATCTTAAGAGCCCTGAATCAGGGTTCCTTGAAAAGGGAGGAACGGCGACATCC
TGACCTAGAGCCCATCCTAAGGCAGCTATTTTCAAGTTCATCACAAGCTTTTCTACAAAGTCAGAAAGTACACAGCTTCTTTCAGTCCAT
ATCATCAGACTCCCTACACAGTATCAATAACTTACAATCCTCTCTGAAGACTTCTAAGATATTAGAACACTTAAAAGAAGACAGCTCTGA
AGCTTCAAGTCAAGAAGAAGATGTGTTGCAGCATGCCATAATCCACAAGAAGCATACTGGGAAAAGTCCCATTGTGAACAATATTGGTAC
AAGTTGTTCTCCATTGGATGGGCTTACCATGCAATATTCTGAACAGAATGGAATTGTGGATTGGAGGAAGCAAAGCTGTACCACCATTCA
ACACCCAGAGCACTGTGTGACCTCGGCTGACCAGCATTCTGCTGAAAAACGGAGTTTATCTTCAATAAATAAGAAGAAAGGAAAGCCACA
AACAGAAAAGGAGAAAATTAAGAAAACTGACAACAGATTGAATAGTAGAATAAATGGTATTAGACTCTCCACTCCTCAGCATGCCCATGG
TGGTACTGTGAAAGATTCCTCAGCAGGAAATGGGGTCCTCACTAAAGCTACAGTCCCCATTTATGCAACAGGAGTCCTTACGTGTTATAT
TCAGGAAGAAGACCGAAAACTGTTAGTTGGATTCTTAGAAGATGTAATGACGCTGCTTTCATTATCTCATGCTCCTCTTGATAGCCTGAA
GGCTTCTTTTGTGGAATTGGGTGCAAACCCAGCCTACCATGAGTTACTATTAACTGTTTTGTGGTATGGTGTTGTCCATACTTCAGCACT
CGTGAGGTGTACTGCTGCTAGAATGTTTGAGCTGACTCTTCGAGGCATGAGTGAAGCGTTAGTTGACAAGCGGGTTGCTCCGGCCCTTGT
TACCTTGTCCAGTGATCCTGAATTCTCTGTCAGGATTGCCACAATTCCAGCCTTTGGCACTATTATGGAAACAGTAATTCAAAGAGAGTT
GCTGGAAAGAGTGAAAATGCAGTTGGCTTCTTTCCTGGAAGATCCTCAGTATCAAGACCAACATTCTTTGCATACAGAGATCATAAAAAC
ATTTGGTAGAGTTGGCCCTAACGCAGAACCCAGGTTCCGAGATGAGTTTGTTATACCACATTTGCATAAGTTAGCCTTGGTGAACAACTT
ACAGATTGTGGATTCTAAAAGACTGGACATTGCTACGCATCTTTTTGAAGCCTACAGTGCACTTTCCTGTTGTTTCATTTCAGAGGATTT
AATGGTTAATCACTTTTTACCTGGTCTCAGATGTTTACGGACTGACATGGAACATCTCTCTCCAGAGCATGAGGTTATTTTAAGTTCCAT
GATAAAAGAATGTGAACAAAAAGTTGAAAACAAGACCGTCCAAGAGCCTCAAGGCTCAATGTCAATTGCTGCAAGCTTAGTGAGTGAAGA
TACAAAGACCAAGTTTTTGAACAAAATGGGCCAGTTGACAACATCAGGTGCCATGTTGGCCAATGTATTTCAGAGAAAGAAGTAGAAGCA
GGAAAGAAGCCCCCAGTAAACACTAAGATGGACCTCAAGCCGACTGGTTCCTTGTACTTGAAGTACTTGCCTTTTTTGTTTCCTCAGTTT
TATGTTCTTGCATTATAATTTTATCCTAACCTCCAAAGATATTTGCACTGCTTTTAATTACTGCTGTATATTTGTTGATTTTGGAGTTAC
AACTGTGGTGATAGAAAATTGAGTTGATGGTCTGTACCAAGTCCCTTGTCTATGTTCTTGTCTTTCAGAATAATTTTTATATAAATATAT
ATATAGTGAAGAAGTTTTTTTTAATTTTTGGATGGGATATTCGCAAATATCTGTATTATACACTAAGCTATTACAATGGTACTTAAAATA
ATGTAAATTTGAAGTCATTGTTATAAAATAATAAAGTGGAGATTACTTAAGTATTTAAATTATGAAAGAATAATGCAGACTTTTTATTGT
TTCTTAACTGACTAGAAAGAGCCACCAGCATTACTCTGTGCCTTTTGGACATCAGTTTGTGTGTTCTGTAGGAATTGTGTGCATTCCATT
CACACAGTATTTCTTTAGGATGCTGTGATGATTTGAATTACAAATCCTACAGTCAATAGCTAAAGACGAAACCTTCATTTCAGAACTCTC
ATGAATATTCTTTAAGTGCTATTTAAACCTCCCCAGCACTTAGATGCATATAATGGACTTACCTGAGGAAAGACAGCACATAGGCATGGG
GAGAGGTAACCAAGGTGAATTTTACAAACTGGTGTATAGTAGATTTAAATGCTCAAAAATAAATGTAACTGAGAAGAGTTAATAATTGTG
AGATTTTTCCCAAATTGAGATACAGAAGAAAATATAGTTTGAATCTGAAATTTAACACTTATTTATGTAAAACACTTTATTTAAGATATT
TTCTAATGATTTTAATTTTAGAGAGTACCTTTTCATTCTGTGTGTTACAGAGAAGTACTGAAAAGTTAAGGACACTTGGGGGCTACTTTT
TTCCCTCTAAACTAAAAAAGACATTGGCTGAATTATAACTAGTTAGTTATCACCTCGTCCCTTAAAGTCAGTGACCTCCTGTGTTTGATG
TATATTACATAGAGTCTTAAGTCAGTGTACAGTTCCACTGGAATTTGACAGTTGTCTCTACAGTCATGCAACTCGAAGTAGAAAAGAGTG
CTGGACATAGGAAGGGGGTGCTTGGTTTGAGGGGTTAATGTGAGGCCTTTTTGAAAAATGAATATTTTGATAAAAAGAATTCTTGTTTTA
GCACAGTTGATGCACATAAGTGATTCTCATATTTGTTGTATAAACTGGTTTAATACATTTGGAACATAGTTGGATTACATTCATTTCCTG
GGAAAGCTAGCTTACCATACATTCAAGTTTATAAAACAATTTGCCATAGGCAAAGCCATTTAAAAAGTTCATTCTGAAATTATTTCATTT
ACCTACAGTGAAATAATTGTGAACTAAGTAGTCTTTCTGAAAACTGTTGGGTTCTAGGCATTCCTGAGAAATTGAAAGTGGCTACCTTTC

>100668_100668_2_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000269499_KIAA1468_chr18_59936101_ENST00000398130_length(amino acids)=938AA_BP=615
MLRMKLPLKPTHPAEPPPEAEEPEADARPGAKAPSRRRRDCRPPPPPPPPAGPSRGPLPPPPPPRGLGPPVAGGAAAGAGMPGGGGGPSA
ALREQERVYEWFGLVLGSAQRLEFMCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGPLADFREPAVRSRLIVYLALL
GSENREAAGRLHRLLPQVDSVLKSLRAARGEGSRGGAEDERGEDGDGEQDAEKDGSGPEGGIVEPRVGGGLGSRAQEELLLLFTMASLHP
AFSFHQRVTLREHLERLRAALRGGPEDAEVEVEPCKFAGPRAQNNSAHGDYMQNNESSLIEQAPIPQDGLTVAPHRAQREAVHIEKIMLK
GVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKELSSETFDKTILRALNQGSLKREERRHPDLEPILRQLFSSSSQAFLQ
SQKVHSFFQSISSDSLHSINNLQSSLKTSKILEHLKEDSSEASSQEEDVLQHAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIV
DWRKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTDNRLNSRINGIRLSTPQHAHGGTVKDSSAGNGVLTKATVP
IYATGVLTCYIQEEDRKLLVGFLEDVMTLLSLSHAPLDSLKASFVELGANPAYHELLLTVLWYGVVHTSALVRCTAARMFELTLRGMSEA
LVDKRVAPALVTLSSDPEFSVRIATIPAFGTIMETVIQRELLERVKMQLASFLEDPQYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIP
HLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGLRCLRTDMEHLSPEHEVILSSMIKECEQKVENKTVQEPQGS

--------------------------------------------------------------
>100668_100668_3_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000586834_KIAA1468_chr18_59936101_ENST00000256858_length(transcript)=3725nt_BP=1074nt
GCTTGCGGCTCTCACACTGTGCCTTTGTGCCCATAGTGTGCAGTCACCTATTGGACCTCTAAAAATTGCCACTAAAATGGTTGTTAGTAA
AATGAGAAGACCTAAATCTGTGATTATTACTCTTAGTCCATGGTTTAAGTTAACGTATCTCCCTCTTTCTCATCTAGAACAACTCTGCTC
ATGGTGATTACATGCAAAATAACGAGAGCAGCTTAATAGAGCAAGCTCCAATACCTCAGGACGGACTTACCGTGGCACCTCACAGAGCTC
AGCGAGAAGCTGTACACATTGAGAAGATAATGTTGAAAGGAGTCCAGAGAAAAAGAGCTGACAAATACTGGGAGTACACTTTCAAAGTAA
ATTGGTCTGATCTTTCAGTCACAACAGTAACAAAAACCCACCAAGAACTACAGGAATTTCTACTGAAGCTTCCAAAGGAACTGTCTTCAG
AGACTTTTGACAAGACCATCTTAAGAGCCCTGAATCAGGGTTCCTTGAAAAGGGAGGAACGGCGACATCCTGACCTAGAGCCCATCCTAA
GGCAGCTATTTTCAAGTTCATCACAAGCTTTTCTACAAAGTCAGAAAGTACACAGCTTCTTTCAGTCCATATCATCAGACTCCCTACACA
GTATCAATAACTTACAATCCTCTCTGAAGACTTCTAAGATATTAGAACACTTAAAAGAAGACAGCTCTGAAGCTTCAAGTCAAGAAGAAG
ATGTGTTGCAGCATGCCATAATCCACAAGAAGCATACTGGGAAAAGTCCCATTGTGAACAATATTGGTACAAGTTGTTCTCCATTGGATG
GGCTTACCATGCAATATTCTGAACAGAATGGAATTGTGGATTGGAGGAAGCAAAGCTGTACCACCATTCAACACCCAGAGCACTGTGTGA
CCTCGGCTGACCAGCATTCTGCTGAAAAACGGAGTTTATCTTCAATAAATAAGAAGAAAGGAAAGCCACAAACAGAAAAGGAGAAAATTA
AGAAAACTGACAACAGATTGAATAGTAGAATAAATGGTATTAGACTCTCCACTCCTCAGCATGCCCATGGTGGTACTGTGAAAGATTCCT
CAGCAGGAAATGGGGTCCTCACTAAAGCTACAGTCCCCATTTATGCAACAGGAGTCCTTACGTGTTATATTCAGATAAAGGAGTATTTGC
ATATACATAATGAGATATCTTGGGAATGGGACCCAAGTCTAAACACAAAATGTGTTTCATATACACATTATACACATAGCCTGAAGGAAG
AAGACCGAAAACTGTTAGTTGGATTCTTAGAAGATGTAATGACGCTGCTTTCATTATCTCATGCTCCTCTTGATAGCCTGAAGGCTTCTT
TTGTGGAATTGGGTGCAAACCCAGCCTACCATGAGTTACTATTAACTGTTTTGTGGTATGGTGTTGTCCATACTTCAGCACTCGTGAGGT
GTACTGCTGCTAGAATGTTTGAGCTGTTGGTGAAGGGGGTGAATGAAACTCTGGTAGCTCAGAGGGTTGTTCCTGCTCTCATTACTCTCT
CCAGTGACCCTGAAATCTCTGTCAGGATTGCCACAATTCCAGCCTTTGGCACTATTATGGAAACAGTAATTCAAAGAGAGTTGCTGGAAA
GAGTGAAAATGCAGTTGGCTTCTTTCCTGGAAGATCCTCAGTATCAAGACCAACATTCTTTGCATACAGAGATCATAAAAACATTTGGTA
GAGTTGGCCCTAACGCAGAACCCAGGTTCCGAGATGAGTTTGTTATACCACATTTGCATAAGTTAGCCTTGGTGAACAACTTACAGATTG
TGGATTCTAAAAGACTGGACATTGCTACGCATCTTTTTGAAGCCTACAGTGCACTTTCCTGTTGTTTCATTTCAGAGGATTTAATGGTTA
ATCACTTTTTACCTGGTCTCAGATGTTTACGGACTGACATGGAACATCTCTCTCCAGAGCATGAGGTTATTTTAAGTTCCATGATAAAAG
AATGTGAACAAAAAGTTGAAAACAAGACCGTCCAAGAGCCTCAAGGCTCAATGTCAATTGCTGCAAGCTTAGTGAGTGAAGATACAAAGA
CCAAGTTTTTGAACAAAATGGGCCAGTTGACAACATCAGGTGCCATGTTGGCCAATGTATTTCAGAGAAAGAAGTAGAAGCAGGAAAGAA
GCCCCCAGTAAACACTAAGATGGACCTCAAGCCGACTGGTTCCTTGTACTTGAAGTACTTGCCTTTTTTGTTTCCTCAGTTTTATGTTCT
TGCATTATAATTTTATCCTAACCTCCAAAGATATTTGCACTGCTTTTAATTACTGCTGTATATTTGTTGATTTTGGAGTTACAACTGTGG
TGATAGAAAATTGAGTTGATGGTCTGTACCAAGTCCCTTGTCTATGTTCTTGTCTTTCAGAATAATTTTTATATAAATATATATATAGTG
AAGAAGTTTTTTTTAATTTTTGGATGGGATATTCGCAAATATCTGTATTATACACTAAGCTATTACAATGGTACTTAAAATAATGTAAAT
TTGAAGTCATTGTTATAAAATAATAAAGTGGAGATTACTTAAGTATTTAAATTATGAAAGAATAATGCAGACTTTTTATTGTTTCTTAAC
TGACTAGAAAGAGCCACCAGCATTACTCTGTGCCTTTTGGACATCAGTTTGTGTGTTCTGTAGGAATTGTGTGCATTCCATTCACACAGT
ATTTCTTTAGGATGCTGTGATGATTTGAATTACAAATCCTACAGTCAATAGCTAAAGACGAAACCTTCATTTCAGAACTCTCATGAATAT
TCTTTAAGTGCTATTTAAACCTCCCCAGCACTTAGATGCATATAATGGACTTACCTGAGGAAAGACAGCACATAGGCATGGGGAGAGGTA
ACCAAGGTGAATTTTACAAACTGGTGTATAGTAGATTTAAATGCTCAAAAATAAATGTAACTGAGAAGAGTTAATAATTGTGAGATTTTT
CCCAAATTGAGATACAGAAGAAAATATAGTTTGAATCTGAAATTTAACACTTATTTATGTAAAACACTTTATTTAAGATATTTTCTAATG
ATTTTAATTTTAGAGAGTACCTTTTCATTCTGTGTGTTACAGAGAAGTACTGAAAAGTTAAGGACACTTGGGGGCTACTTTTTTCCCTCT
AAACTAAAAAAGACATTGGCTGAATTATAACTAGTTAGTTATCACCTCGTCCCTTAAAGTCAGTGACCTCCTGTGTTTGATGTATATTAC
ATAGAGTCTTAAGTCAGTGTACAGTTCCACTGGAATTTGACAGTTGTCTCTACAGTCATGCAACTCGAAGTAGAAAAGAGTGCTGGACAT
AGGAAGGGGGTGCTTGGTTTGAGGGGTTAATGTGAGGCCTTTTTGAAAAATGAATATTTTGATAAAAAGAATTCTTGTTTTAGCACAGTT
GATGCACATAAGTGATTCTCATATTTGTTGTATAAACTGGTTTAATACATTTGGAACATAGTTGGATTACATTCATTTCCTGGGAAAGCT
AGCTTACCATACATTCAAGTTTATAAAACAATTTGCCATAGGCAAAGCCATTTAAAAAGTTCATTCTGAAATTATTTCATTTACCTACAG
TGAAATAATTGTGAACTAAGTAGTCTTTCTGAAAACTGTTGGGTTCTAGGCATTCCTGAGAAATTGAAAGTGGCTACCTTTCATGTCAAA

>100668_100668_3_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000586834_KIAA1468_chr18_59936101_ENST00000256858_length(amino acids)=651AA_BP=294
MQNNESSLIEQAPIPQDGLTVAPHRAQREAVHIEKIMLKGVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKELSSETFD
KTILRALNQGSLKREERRHPDLEPILRQLFSSSSQAFLQSQKVHSFFQSISSDSLHSINNLQSSLKTSKILEHLKEDSSEASSQEEDVLQ
HAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIVDWRKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTD
NRLNSRINGIRLSTPQHAHGGTVKDSSAGNGVLTKATVPIYATGVLTCYIQIKEYLHIHNEISWEWDPSLNTKCVSYTHYTHSLKEEDRK
LLVGFLEDVMTLLSLSHAPLDSLKASFVELGANPAYHELLLTVLWYGVVHTSALVRCTAARMFELLVKGVNETLVAQRVVPALITLSSDP
EISVRIATIPAFGTIMETVIQRELLERVKMQLASFLEDPQYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIPHLHKLALVNNLQIVDSK
RLDIATHLFEAYSALSCCFISEDLMVNHFLPGLRCLRTDMEHLSPEHEVILSSMIKECEQKVENKTVQEPQGSMSIAASLVSEDTKTKFL

--------------------------------------------------------------
>100668_100668_4_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000586834_KIAA1468_chr18_59936101_ENST00000398130_length(transcript)=3633nt_BP=1074nt
GCTTGCGGCTCTCACACTGTGCCTTTGTGCCCATAGTGTGCAGTCACCTATTGGACCTCTAAAAATTGCCACTAAAATGGTTGTTAGTAA
AATGAGAAGACCTAAATCTGTGATTATTACTCTTAGTCCATGGTTTAAGTTAACGTATCTCCCTCTTTCTCATCTAGAACAACTCTGCTC
ATGGTGATTACATGCAAAATAACGAGAGCAGCTTAATAGAGCAAGCTCCAATACCTCAGGACGGACTTACCGTGGCACCTCACAGAGCTC
AGCGAGAAGCTGTACACATTGAGAAGATAATGTTGAAAGGAGTCCAGAGAAAAAGAGCTGACAAATACTGGGAGTACACTTTCAAAGTAA
ATTGGTCTGATCTTTCAGTCACAACAGTAACAAAAACCCACCAAGAACTACAGGAATTTCTACTGAAGCTTCCAAAGGAACTGTCTTCAG
AGACTTTTGACAAGACCATCTTAAGAGCCCTGAATCAGGGTTCCTTGAAAAGGGAGGAACGGCGACATCCTGACCTAGAGCCCATCCTAA
GGCAGCTATTTTCAAGTTCATCACAAGCTTTTCTACAAAGTCAGAAAGTACACAGCTTCTTTCAGTCCATATCATCAGACTCCCTACACA
GTATCAATAACTTACAATCCTCTCTGAAGACTTCTAAGATATTAGAACACTTAAAAGAAGACAGCTCTGAAGCTTCAAGTCAAGAAGAAG
ATGTGTTGCAGCATGCCATAATCCACAAGAAGCATACTGGGAAAAGTCCCATTGTGAACAATATTGGTACAAGTTGTTCTCCATTGGATG
GGCTTACCATGCAATATTCTGAACAGAATGGAATTGTGGATTGGAGGAAGCAAAGCTGTACCACCATTCAACACCCAGAGCACTGTGTGA
CCTCGGCTGACCAGCATTCTGCTGAAAAACGGAGTTTATCTTCAATAAATAAGAAGAAAGGAAAGCCACAAACAGAAAAGGAGAAAATTA
AGAAAACTGACAACAGATTGAATAGTAGAATAAATGGTATTAGACTCTCCACTCCTCAGCATGCCCATGGTGGTACTGTGAAAGATTCCT
CAGCAGGAAATGGGGTCCTCACTAAAGCTACAGTCCCCATTTATGCAACAGGAGTCCTTACGTGTTATATTCAGGAAGAAGACCGAAAAC
TGTTAGTTGGATTCTTAGAAGATGTAATGACGCTGCTTTCATTATCTCATGCTCCTCTTGATAGCCTGAAGGCTTCTTTTGTGGAATTGG
GTGCAAACCCAGCCTACCATGAGTTACTATTAACTGTTTTGTGGTATGGTGTTGTCCATACTTCAGCACTCGTGAGGTGTACTGCTGCTA
GAATGTTTGAGCTGACTCTTCGAGGCATGAGTGAAGCGTTAGTTGACAAGCGGGTTGCTCCGGCCCTTGTTACCTTGTCCAGTGATCCTG
AATTCTCTGTCAGGATTGCCACAATTCCAGCCTTTGGCACTATTATGGAAACAGTAATTCAAAGAGAGTTGCTGGAAAGAGTGAAAATGC
AGTTGGCTTCTTTCCTGGAAGATCCTCAGTATCAAGACCAACATTCTTTGCATACAGAGATCATAAAAACATTTGGTAGAGTTGGCCCTA
ACGCAGAACCCAGGTTCCGAGATGAGTTTGTTATACCACATTTGCATAAGTTAGCCTTGGTGAACAACTTACAGATTGTGGATTCTAAAA
GACTGGACATTGCTACGCATCTTTTTGAAGCCTACAGTGCACTTTCCTGTTGTTTCATTTCAGAGGATTTAATGGTTAATCACTTTTTAC
CTGGTCTCAGATGTTTACGGACTGACATGGAACATCTCTCTCCAGAGCATGAGGTTATTTTAAGTTCCATGATAAAAGAATGTGAACAAA
AAGTTGAAAACAAGACCGTCCAAGAGCCTCAAGGCTCAATGTCAATTGCTGCAAGCTTAGTGAGTGAAGATACAAAGACCAAGTTTTTGA
ACAAAATGGGCCAGTTGACAACATCAGGTGCCATGTTGGCCAATGTATTTCAGAGAAAGAAGTAGAAGCAGGAAAGAAGCCCCCAGTAAA
CACTAAGATGGACCTCAAGCCGACTGGTTCCTTGTACTTGAAGTACTTGCCTTTTTTGTTTCCTCAGTTTTATGTTCTTGCATTATAATT
TTATCCTAACCTCCAAAGATATTTGCACTGCTTTTAATTACTGCTGTATATTTGTTGATTTTGGAGTTACAACTGTGGTGATAGAAAATT
GAGTTGATGGTCTGTACCAAGTCCCTTGTCTATGTTCTTGTCTTTCAGAATAATTTTTATATAAATATATATATAGTGAAGAAGTTTTTT
TTAATTTTTGGATGGGATATTCGCAAATATCTGTATTATACACTAAGCTATTACAATGGTACTTAAAATAATGTAAATTTGAAGTCATTG
TTATAAAATAATAAAGTGGAGATTACTTAAGTATTTAAATTATGAAAGAATAATGCAGACTTTTTATTGTTTCTTAACTGACTAGAAAGA
GCCACCAGCATTACTCTGTGCCTTTTGGACATCAGTTTGTGTGTTCTGTAGGAATTGTGTGCATTCCATTCACACAGTATTTCTTTAGGA
TGCTGTGATGATTTGAATTACAAATCCTACAGTCAATAGCTAAAGACGAAACCTTCATTTCAGAACTCTCATGAATATTCTTTAAGTGCT
ATTTAAACCTCCCCAGCACTTAGATGCATATAATGGACTTACCTGAGGAAAGACAGCACATAGGCATGGGGAGAGGTAACCAAGGTGAAT
TTTACAAACTGGTGTATAGTAGATTTAAATGCTCAAAAATAAATGTAACTGAGAAGAGTTAATAATTGTGAGATTTTTCCCAAATTGAGA
TACAGAAGAAAATATAGTTTGAATCTGAAATTTAACACTTATTTATGTAAAACACTTTATTTAAGATATTTTCTAATGATTTTAATTTTA
GAGAGTACCTTTTCATTCTGTGTGTTACAGAGAAGTACTGAAAAGTTAAGGACACTTGGGGGCTACTTTTTTCCCTCTAAACTAAAAAAG
ACATTGGCTGAATTATAACTAGTTAGTTATCACCTCGTCCCTTAAAGTCAGTGACCTCCTGTGTTTGATGTATATTACATAGAGTCTTAA
GTCAGTGTACAGTTCCACTGGAATTTGACAGTTGTCTCTACAGTCATGCAACTCGAAGTAGAAAAGAGTGCTGGACATAGGAAGGGGGTG
CTTGGTTTGAGGGGTTAATGTGAGGCCTTTTTGAAAAATGAATATTTTGATAAAAAGAATTCTTGTTTTAGCACAGTTGATGCACATAAG
TGATTCTCATATTTGTTGTATAAACTGGTTTAATACATTTGGAACATAGTTGGATTACATTCATTTCCTGGGAAAGCTAGCTTACCATAC
ATTCAAGTTTATAAAACAATTTGCCATAGGCAAAGCCATTTAAAAAGTTCATTCTGAAATTATTTCATTTACCTACAGTGAAATAATTGT
GAACTAAGTAGTCTTTCTGAAAACTGTTGGGTTCTAGGCATTCCTGAGAAATTGAAAGTGGCTACCTTTCATGTCAAAAATGTTGATCTA

>100668_100668_4_ZCCHC2-KIAA1468_ZCCHC2_chr18_60232329_ENST00000586834_KIAA1468_chr18_59936101_ENST00000398130_length(amino acids)=617AA_BP=294
MQNNESSLIEQAPIPQDGLTVAPHRAQREAVHIEKIMLKGVQRKRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKELSSETFD
KTILRALNQGSLKREERRHPDLEPILRQLFSSSSQAFLQSQKVHSFFQSISSDSLHSINNLQSSLKTSKILEHLKEDSSEASSQEEDVLQ
HAIIHKKHTGKSPIVNNIGTSCSPLDGLTMQYSEQNGIVDWRKQSCTTIQHPEHCVTSADQHSAEKRSLSSINKKKGKPQTEKEKIKKTD
NRLNSRINGIRLSTPQHAHGGTVKDSSAGNGVLTKATVPIYATGVLTCYIQEEDRKLLVGFLEDVMTLLSLSHAPLDSLKASFVELGANP
AYHELLLTVLWYGVVHTSALVRCTAARMFELTLRGMSEALVDKRVAPALVTLSSDPEFSVRIATIPAFGTIMETVIQRELLERVKMQLAS
FLEDPQYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIPHLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGLR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZCCHC2-KIAA1468


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneKIAA1468chr18:60232329chr18:59936101ENST000002568581830497_779893.33333333333341251.0RAB11A and RAB11B
TgeneKIAA1468chr18:60232329chr18:59936101ENST000003981301829497_779893.33333333333341217.0RAB11A and RAB11B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZCCHC2-KIAA1468


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZCCHC2-KIAA1468


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource