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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZDHHC17-C10orf112 (FusionGDB2 ID:100757)

Fusion Gene Summary for ZDHHC17-C10orf112

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC17-C10orf112
Fusion gene ID: 100757
HgeneTgene
Gene symbol

ZDHHC17

C10orf112

Gene ID

23390

340895

Gene namezinc finger DHHC-type palmitoyltransferase 17MAM and LDL receptor class A domain containing 1
SynonymsDHHC-17|HIP14|HIP3|HSPC294|HYPHC10orf112|DIET1|bA265G8.2
Cytomap

12q21.2

10p12.31

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC17huntingtin interacting protein 14huntingtin interacting protein 3huntingtin yeast partner Hhuntingtin-interacting protein Hputative MAPK-activating protein PM11putative NF-kappa-B-activating protein 205zinc finger DHHC dMAM and LDL-receptor class A domain-containing protein 1MAM and LDL-receptor class A domain-containing protein C10orf112novel MAM domain containing protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334822, ENST00000359019, 
ENST00000426126, ENST00000550789, 
ENST00000455457, ENST00000492202, 
ENST00000454679, 
Fusion gene scores* DoF score19 X 6 X 9=10265 X 5 X 4=100
# samples 225
** MAII scorelog2(22/1026*10)=-2.22145530208239
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZDHHC17 [Title/Abstract] AND C10orf112 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZDHHC17(77158109)-C10orf112(19546613), # samples:1
Anticipated loss of major functional domain due to fusion event.ZDHHC17-C10orf112 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZDHHC17

GO:0018345

protein palmitoylation

23034182

HgeneZDHHC17

GO:0042953

lipoprotein transport

15603740


check buttonFusion gene breakpoints across ZDHHC17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C10orf112 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L4-01AZDHHC17chr12

77158109

-C10orf112chr10

19546613

+


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Fusion Gene ORF analysis for ZDHHC17-C10orf112

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334822ENST00000455457ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
5CDS-intronENST00000334822ENST00000492202ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
5CDS-intronENST00000359019ENST00000455457ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
5CDS-intronENST00000359019ENST00000492202ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
5CDS-intronENST00000426126ENST00000455457ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
5CDS-intronENST00000426126ENST00000492202ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
Frame-shiftENST00000359019ENST00000454679ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
In-frameENST00000334822ENST00000454679ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
In-frameENST00000426126ENST00000454679ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
intron-3CDSENST00000550789ENST00000454679ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
intron-intronENST00000550789ENST00000455457ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+
intron-intronENST00000550789ENST00000492202ZDHHC17chr12

77158109

-C10orf112chr10

19546613

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334822ZDHHC17chr1277158109-ENST00000454679C10orf112chr1019546613+452474231342841323
ENST00000426126ZDHHC17chr1277158109-ENST00000454679C10orf112chr1019546613+452474231342841323

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334822ENST00000454679ZDHHC17chr1277158109-C10orf112chr1019546613+0.0008100690.9991899
ENST00000426126ENST00000454679ZDHHC17chr1277158109-C10orf112chr1019546613+0.0008100690.9991899

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Fusion Genomic Features for ZDHHC17-C10orf112


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZDHHC17-C10orf112


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:77158109/chr10:19546613)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117437_48731633.0DomainDHHC
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17437_48715217.0DomainDHHC
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117437_48731633.0DomainDHHC
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117123_15231633.0RepeatANK 3
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117156_18531633.0RepeatANK 4
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117189_21931633.0RepeatANK 5
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117224_25331633.0RepeatANK 6
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117257_28631633.0RepeatANK 7
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-11751_8631633.0RepeatANK 1
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-11789_11831633.0RepeatANK 2
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17123_15215217.0RepeatANK 3
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17156_18515217.0RepeatANK 4
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17189_21915217.0RepeatANK 5
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17224_25315217.0RepeatANK 6
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17257_28615217.0RepeatANK 7
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-1751_8615217.0RepeatANK 1
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-1789_11815217.0RepeatANK 2
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117123_15231633.0RepeatANK 3
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117156_18531633.0RepeatANK 4
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117189_21931633.0RepeatANK 5
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117224_25331633.0RepeatANK 6
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117257_28631633.0RepeatANK 7
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-11751_8631633.0RepeatANK 1
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-11789_11831633.0RepeatANK 2
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-1171_30431633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117347_35731633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117379_38131633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117403_48031633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117502_52931633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117551_63231633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-171_30415217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17347_35715217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17379_38115217.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17403_48015217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17502_52915217.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17551_63215217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-1171_30431633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117347_35731633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117379_38131633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117403_48031633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117502_52931633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117551_63231633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117305_32531633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117326_34631633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117358_37831633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117382_40231633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117481_50131633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000334822-117530_55031633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17305_32515217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17326_34615217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17358_37815217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17382_40215217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17481_50115217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000359019-17530_55015217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117305_32531633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117326_34631633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117358_37831633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117382_40231633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117481_50131633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr10:19546613ENST00000426126-117530_55031633.0TransmembraneHelical


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Fusion Gene Sequence for ZDHHC17-C10orf112


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100757_100757_1_ZDHHC17-C10orf112_ZDHHC17_chr12_77158109_ENST00000334822_C10orf112_chr10_19546613_ENST00000454679_length(transcript)=4524nt_BP=742nt
TTGTATCCATGTTTTTCCGGGCGTCCCCCGGAGGGACAGGTTGCGGGTGACCTTTTCAAGTGTGGAGGAAAGGGAAGCTGCTTTTGTCTT
CAGGAATGATGCAGGTCTCGACTCAAGCCTGACGGGCCCAAACCTCCCTGGAGCTGGCTGACGACTCTGCCCGAGTTCCTGAAGAGGGGT
CCCGGGGGTCCCGGAGCGGAAGTGGGAGCGCGTGGGCGTGGGCTCCTCGGCTGCCTGGGGCTCCAGACTTGTGCTGCGTGCGGCTCCGGA
GCTCTGTTCTCGCTCCTGAGCAGCTGCTAGGTTTCCCAAGCGACTGTCTCAACCGCCCGGCCGCCTCCCCCGGGCAGCCAGAGCTTCACA
TCTACCTCCAGCCGGGACCCGCCCCCGAGCCGCGGGGCCCACGCCCAGAGCCCTCCGCCGTCCCCAGCGCAGTGCAGCAGAGCGCGATCC
AGTCTGGGGCCGGGCCGCGCTTCCGCGCACGCGCGGAGAAACCCGCGCCCTCCGAGGGGGGAGGGGACAGAGGGGGCGTCACGGGGGCAG
GAGAAGAAGGAGGAGGAGGCCCGCGTCGCCTCCGGCGGGGCTCGCGCTCGCCCCGCGCTCGCCCTCCGCCTCGCCCGAGCCCCGGGAGGG
TGAAACGCTTTCTCCCAGCATGCAGCGGGAGGAGGGATTTAACACCAAGATGGCGGACGGCCCGGATGAGTACGATACCGAAGCGGGCTG
TGTGCCCCTTCTCCACCCAGAGATATTGGTGGAGGCTTCAGTGGGAGATGGCTTCACTGGAGATATTGCGATTGATGATCTGTCATTTAT
GGACTGCACCCTCTACCCTGGTAATTTGCCAGCAGACCTCCCAACTCCACCAGAAACGTCAGTTCCTGTAACATTACCTCCACACAACTG
CACAGACAATGAATTTATCTGCAGGTCTGATGGTCACTGCATTGAAAAAATGCAGAAATGTGATTTTAAATATGACTGCCCTGACAAATC
AGATGAAGCATCCTGTGTTATGGAAGTTTGCAGCTTTGAGAAAAGAAGCCTGTGTAAATGGTATCAACCAATCCCAGTACATTTGCTTCA
AGATTCAAACACATTCAGGTGGGGGCTTGGGAACGGGATCAGCATTCATCATGGGGAAGAAAACCACAGGCCATCAGTGGATCATACACA
AAATACCACTGATGGCTGGTACCTGTATGCTGACAGTTCTAATGGGAAATTTGGTGACACGGCTGACATTCTCACTCCTATCATTTCACT
CACGGGACCAAAATGTACCTTGGTGTTCTGGACACATATGAATGGGGCCACCGTTGGTTCTCTCCAGGTGCTCATCAAGAAAGATAACGT
TACTTCTAAATTGTGGGCTCAAACTGGACAGCAAGGTGCACAGTGGAAGAGAGCAGAAGTGTTTTTAGGCATTCGTTCACATACACAGAT
TGTCTTCAGAGCCAAACGTGGTATCAGTTACATAGGAGATGTAGCAGTGGATGATATTTCCTTCCAAGATTGCTCCCCTTTGCTTAGCCC
AGAGAGAAAGTGTACTGATCATGAATTCATGTGTGCTAATAAGCACTGCATTGCCAAAGACAAGCTGTGTGATTTTGTGAATGATTGTGC
TGATAATTCAGATGAGACTACTTTCATTTGCCGTACCTCCAGTGGGCGCTGTGATTTCGAATTTGATCTTTGTTCCTGGAAGCAGGAGAA
AGATGAGGACTTTGACTGGAACCTGAAAGCTAGCAGCATCCCTGCAGCAGGCACAGAGCCAGCAGCAGATCACACTTTGGGAAATTCATC
TGGTCATTACATCTTTATAAAGAGTTTGTTTCCTCAGCAGCCCATGAGAGCTGCCAGAATTTCAAGTCCAGTTATAAGTAAGAGAAGCAA
AAACTGCAAGATTATTTTTCATTATCACATGTATGGAAATGGCATTGGGGCACTCACCTTAATGCAGGTGTCAGTCACAAACCAAACGAA
GGTTCTACTTAACCTCACTGTAGAACAAGGCAATTTCTGGCGGAGAGAAGAACTGTCACTGTTTGGTGATGAAGACTTCCAACTCAAATT
TGAAGGTAGAGTTGGGAAAGGTCAGCGTGGAGACATTGCACTTGATGACATTGTGCTTACAGAAAATTGTCTATCACTCCATGATTCCGT
GCAAGAAGAACTGGCAGTGCCTCTTCCAACAGGTTTCTGCCCACTTGGCTATAGGGAATGTCATAATGGAAAATGCTATAGGCTGGAACA
AAGCTGTAACTTCGTAGATAACTGTGGAGATAATACTGATGAAAATGAGTGTGGTAGCTCCTGTACTTTTGAAAAAGGCTGGTGTGGCTG
GCAAAACTCCCAGGCTGACAACTTTGATTGGGTTTTAGGGGTTGGCTCTCATCAAAGCTTAAGACCTCCCAAAGACCACACACTTGGAAA
TGAAAATGCTATCTTGTTGATGCGACGGCATAAATATCCCATCAGATCAGTTAATCTGCATACTGTGAAGCACGTGCTAAAAGCACAGAC
AGTTGGAAATTGTTCTGTCAGCAAGCTAGAGGCGAGGCTATTAGATTTTCTTTCTGTTCCAAATGAAAATACTTTTGGCAGCTCAGATCA
TACGAATTGGCACTTCATGTATCTGGAAGCTACTGCAGTGGGCCTTCGGGGTGACAAAGCACACTTCAGGAGTACCATGTGGCGAGAATC
CAGTGCAGCCTGCACCATGAGCTTCTGGTATTTCGTATCTGCAAAGGCCACAGGATCCATTCAGATTCTCATCAAGCGGGGGCGGAGGAG
AAGGCGGGCTCCCAATCCGGTTCTATCCGGTTCTCCCACCATCCCCCGCCAGGGGTCTCAGCAGCTCGGAGGGTGGAGGGGCGGCAGCGC
CAGGCACCGCGCACGCGCCTTTCCGGAGCCAGAATGCCCAAGAGGAAGGTCAGCTCTGCTGAAGGGGCCGCCACAGGAAAAGCCTAACAG
GAGGTCAGCGCTGTTGTCAGTGGGAGAGATCTCTGAGCTTTGTCCGGAAATCACTGATTTTTTGTGCCGGGACAAGAAGTGCATTGCATC
CCACCTTCTTTGTGACTATAAGCCAGACTGCTCTGATAGGTCTGATGAAGCTCACTGTGCACATTATACAAGCACAACAGGAAGCTGCAA
TTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAGTCTTACTCAAGACTCTGAGGATGACTTGGACTGGGCCATTGGCAGCAGAAT
TCCTGCCAAAGCATTAATTCCAGACTCTGATCACACGCCAGGTAGTGGTCAGCACTTCCTGTACGTCAACTCATCTGGCTCCAAGGAAGG
ATCCGTTGCCAGAATTACTACTTCCAAATCCTTCCCAGCAAGCCTTGGAATGTGTACTGTTCGGTTCTGGTTCTACATGATTGATCCCAG
GAGTATGGGAATATTAAAGGTGTATACCATTGAAGAATCGGGGCTAAACATCCTGGTGTGGTCAGTGATTGGAAATAAAAGAACGGGATG
GACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTTTAAGGTGGCATTTGAAGCTGATTTGGATGGAAATGAGGACATCTTTATTGC
TCTTGATGACATCTCTTTTACCCCAGAGTGTGTGACTGGAGGTCCTGTCCCAGTGCAGCCATCACCCTGTGAAGCTGATCAGTTTTCTTG
TATCTACACACTCCAATGTGTCCCTCTCTCAGGGAAATGTGATGGACATGAAGACTGCATAGATGGATCTGATGAAATGGATTGTCCTCT
CAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCCGTGCTCTACAGACGAGTGTATACCTTCCCTCCTGCTATGCGATGGAGTGCC
CGACTGCCACTTTAATGAAGATGAGCTCATCTGCTCCAACAAAAGCTGTTCTAATGGAGCTCTGGTGTGTGCCTCCTCCAACAGCTGTAT
CCCAGCCCACCAGCGCTGTGATGGTTTTGCCGACTGCATGGATTTCCAGCTTGATGAGTCCAGCTGCTCCGATACATGGACTCTCCTGGG
TATTGGATTAGCATTCCTGATGACTCACATCACAGTTGCAGTCTTGTGTTTTCTTGCAAACAGAAAGGTACCAATAAGGAAAACCGAGGG
AAGTGGTAACTGTGCCTTTGTCAATCCAGTTTACGGGAACTGGAGCAACCCAGAGAAAACAGAGAGTTCTGTCTATTCCTTCTCAAACCC
ATTATATGGCACAACATCAGGAAGCCTGGAGACCCTGTCACATCATCTCAAATAGCAGCATCGAGACCAAGTCTGATCCAACATGTGTAG
TTTCTAGAAAATTGAAGTCTCCACAATCTGATAGAAACTCATCTTCTACAATGGTAAAAAGAGAAAGGATTGTAAATGCCAGTGTAATTA
TAACATTTATGAATGAATTTTCTTGCAGAATATAGAGAATGTTTATATGGAATCAGAATCAGTACCTTATCTTCACTGAACATCTGAATA

>100757_100757_1_ZDHHC17-C10orf112_ZDHHC17_chr12_77158109_ENST00000334822_C10orf112_chr10_19546613_ENST00000454679_length(amino acids)=1323AA_BP=143
MSQPPGRLPRAARASHLPPAGTRPRAAGPTPRALRRPQRSAAERDPVWGRAALPRTRGETRALRGGRGQRGRHGGRRRRRRRPASPPAGL
ALAPRSPSASPEPREGETLSPSMQREEGFNTKMADGPDEYDTEAGCVPLLHPEILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLP
TPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGIS
IHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQ
WKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSS
GRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNG
IGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCP
LGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPI
RSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPNENTFGSSDHTNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSA
KATGSIQILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLKGPPQEKPNRRSALLSVGEISELC
PEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPG
SGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFK
VAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPC
STDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDTWTLLGIGLAFLMTHITVAV

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>100757_100757_2_ZDHHC17-C10orf112_ZDHHC17_chr12_77158109_ENST00000426126_C10orf112_chr10_19546613_ENST00000454679_length(transcript)=4524nt_BP=742nt
TTGTATCCATGTTTTTCCGGGCGTCCCCCGGAGGGACAGGTTGCGGGTGACCTTTTCAAGTGTGGAGGAAAGGGAAGCTGCTTTTGTCTT
CAGGAATGATGCAGGTCTCGACTCAAGCCTGACGGGCCCAAACCTCCCTGGAGCTGGCTGACGACTCTGCCCGAGTTCCTGAAGAGGGGT
CCCGGGGGTCCCGGAGCGGAAGTGGGAGCGCGTGGGCGTGGGCTCCTCGGCTGCCTGGGGCTCCAGACTTGTGCTGCGTGCGGCTCCGGA
GCTCTGTTCTCGCTCCTGAGCAGCTGCTAGGTTTCCCAAGCGACTGTCTCAACCGCCCGGCCGCCTCCCCCGGGCAGCCAGAGCTTCACA
TCTACCTCCAGCCGGGACCCGCCCCCGAGCCGCGGGGCCCACGCCCAGAGCCCTCCGCCGTCCCCAGCGCAGTGCAGCAGAGCGCGATCC
AGTCTGGGGCCGGGCCGCGCTTCCGCGCACGCGCGGAGAAACCCGCGCCCTCCGAGGGGGGAGGGGACAGAGGGGGCGTCACGGGGGCAG
GAGAAGAAGGAGGAGGAGGCCCGCGTCGCCTCCGGCGGGGCTCGCGCTCGCCCCGCGCTCGCCCTCCGCCTCGCCCGAGCCCCGGGAGGG
TGAAACGCTTTCTCCCAGCATGCAGCGGGAGGAGGGATTTAACACCAAGATGGCGGACGGCCCGGATGAGTACGATACCGAAGCGGGCTG
TGTGCCCCTTCTCCACCCAGAGATATTGGTGGAGGCTTCAGTGGGAGATGGCTTCACTGGAGATATTGCGATTGATGATCTGTCATTTAT
GGACTGCACCCTCTACCCTGGTAATTTGCCAGCAGACCTCCCAACTCCACCAGAAACGTCAGTTCCTGTAACATTACCTCCACACAACTG
CACAGACAATGAATTTATCTGCAGGTCTGATGGTCACTGCATTGAAAAAATGCAGAAATGTGATTTTAAATATGACTGCCCTGACAAATC
AGATGAAGCATCCTGTGTTATGGAAGTTTGCAGCTTTGAGAAAAGAAGCCTGTGTAAATGGTATCAACCAATCCCAGTACATTTGCTTCA
AGATTCAAACACATTCAGGTGGGGGCTTGGGAACGGGATCAGCATTCATCATGGGGAAGAAAACCACAGGCCATCAGTGGATCATACACA
AAATACCACTGATGGCTGGTACCTGTATGCTGACAGTTCTAATGGGAAATTTGGTGACACGGCTGACATTCTCACTCCTATCATTTCACT
CACGGGACCAAAATGTACCTTGGTGTTCTGGACACATATGAATGGGGCCACCGTTGGTTCTCTCCAGGTGCTCATCAAGAAAGATAACGT
TACTTCTAAATTGTGGGCTCAAACTGGACAGCAAGGTGCACAGTGGAAGAGAGCAGAAGTGTTTTTAGGCATTCGTTCACATACACAGAT
TGTCTTCAGAGCCAAACGTGGTATCAGTTACATAGGAGATGTAGCAGTGGATGATATTTCCTTCCAAGATTGCTCCCCTTTGCTTAGCCC
AGAGAGAAAGTGTACTGATCATGAATTCATGTGTGCTAATAAGCACTGCATTGCCAAAGACAAGCTGTGTGATTTTGTGAATGATTGTGC
TGATAATTCAGATGAGACTACTTTCATTTGCCGTACCTCCAGTGGGCGCTGTGATTTCGAATTTGATCTTTGTTCCTGGAAGCAGGAGAA
AGATGAGGACTTTGACTGGAACCTGAAAGCTAGCAGCATCCCTGCAGCAGGCACAGAGCCAGCAGCAGATCACACTTTGGGAAATTCATC
TGGTCATTACATCTTTATAAAGAGTTTGTTTCCTCAGCAGCCCATGAGAGCTGCCAGAATTTCAAGTCCAGTTATAAGTAAGAGAAGCAA
AAACTGCAAGATTATTTTTCATTATCACATGTATGGAAATGGCATTGGGGCACTCACCTTAATGCAGGTGTCAGTCACAAACCAAACGAA
GGTTCTACTTAACCTCACTGTAGAACAAGGCAATTTCTGGCGGAGAGAAGAACTGTCACTGTTTGGTGATGAAGACTTCCAACTCAAATT
TGAAGGTAGAGTTGGGAAAGGTCAGCGTGGAGACATTGCACTTGATGACATTGTGCTTACAGAAAATTGTCTATCACTCCATGATTCCGT
GCAAGAAGAACTGGCAGTGCCTCTTCCAACAGGTTTCTGCCCACTTGGCTATAGGGAATGTCATAATGGAAAATGCTATAGGCTGGAACA
AAGCTGTAACTTCGTAGATAACTGTGGAGATAATACTGATGAAAATGAGTGTGGTAGCTCCTGTACTTTTGAAAAAGGCTGGTGTGGCTG
GCAAAACTCCCAGGCTGACAACTTTGATTGGGTTTTAGGGGTTGGCTCTCATCAAAGCTTAAGACCTCCCAAAGACCACACACTTGGAAA
TGAAAATGCTATCTTGTTGATGCGACGGCATAAATATCCCATCAGATCAGTTAATCTGCATACTGTGAAGCACGTGCTAAAAGCACAGAC
AGTTGGAAATTGTTCTGTCAGCAAGCTAGAGGCGAGGCTATTAGATTTTCTTTCTGTTCCAAATGAAAATACTTTTGGCAGCTCAGATCA
TACGAATTGGCACTTCATGTATCTGGAAGCTACTGCAGTGGGCCTTCGGGGTGACAAAGCACACTTCAGGAGTACCATGTGGCGAGAATC
CAGTGCAGCCTGCACCATGAGCTTCTGGTATTTCGTATCTGCAAAGGCCACAGGATCCATTCAGATTCTCATCAAGCGGGGGCGGAGGAG
AAGGCGGGCTCCCAATCCGGTTCTATCCGGTTCTCCCACCATCCCCCGCCAGGGGTCTCAGCAGCTCGGAGGGTGGAGGGGCGGCAGCGC
CAGGCACCGCGCACGCGCCTTTCCGGAGCCAGAATGCCCAAGAGGAAGGTCAGCTCTGCTGAAGGGGCCGCCACAGGAAAAGCCTAACAG
GAGGTCAGCGCTGTTGTCAGTGGGAGAGATCTCTGAGCTTTGTCCGGAAATCACTGATTTTTTGTGCCGGGACAAGAAGTGCATTGCATC
CCACCTTCTTTGTGACTATAAGCCAGACTGCTCTGATAGGTCTGATGAAGCTCACTGTGCACATTATACAAGCACAACAGGAAGCTGCAA
TTTTGAAACAAGTTCAGGAAACTGGACCACAGCCTGCAGTCTTACTCAAGACTCTGAGGATGACTTGGACTGGGCCATTGGCAGCAGAAT
TCCTGCCAAAGCATTAATTCCAGACTCTGATCACACGCCAGGTAGTGGTCAGCACTTCCTGTACGTCAACTCATCTGGCTCCAAGGAAGG
ATCCGTTGCCAGAATTACTACTTCCAAATCCTTCCCAGCAAGCCTTGGAATGTGTACTGTTCGGTTCTGGTTCTACATGATTGATCCCAG
GAGTATGGGAATATTAAAGGTGTATACCATTGAAGAATCGGGGCTAAACATCCTGGTGTGGTCAGTGATTGGAAATAAAAGAACGGGATG
GACATATGGCTCTGTGCCTCTCTCCAGTAACAGTCCGTTTAAGGTGGCATTTGAAGCTGATTTGGATGGAAATGAGGACATCTTTATTGC
TCTTGATGACATCTCTTTTACCCCAGAGTGTGTGACTGGAGGTCCTGTCCCAGTGCAGCCATCACCCTGTGAAGCTGATCAGTTTTCTTG
TATCTACACACTCCAATGTGTCCCTCTCTCAGGGAAATGTGATGGACATGAAGACTGCATAGATGGATCTGATGAAATGGATTGTCCTCT
CAGCCCCACCCCTCCACTCTGTAGTAACATGGAGTTCCCGTGCTCTACAGACGAGTGTATACCTTCCCTCCTGCTATGCGATGGAGTGCC
CGACTGCCACTTTAATGAAGATGAGCTCATCTGCTCCAACAAAAGCTGTTCTAATGGAGCTCTGGTGTGTGCCTCCTCCAACAGCTGTAT
CCCAGCCCACCAGCGCTGTGATGGTTTTGCCGACTGCATGGATTTCCAGCTTGATGAGTCCAGCTGCTCCGATACATGGACTCTCCTGGG
TATTGGATTAGCATTCCTGATGACTCACATCACAGTTGCAGTCTTGTGTTTTCTTGCAAACAGAAAGGTACCAATAAGGAAAACCGAGGG
AAGTGGTAACTGTGCCTTTGTCAATCCAGTTTACGGGAACTGGAGCAACCCAGAGAAAACAGAGAGTTCTGTCTATTCCTTCTCAAACCC
ATTATATGGCACAACATCAGGAAGCCTGGAGACCCTGTCACATCATCTCAAATAGCAGCATCGAGACCAAGTCTGATCCAACATGTGTAG
TTTCTAGAAAATTGAAGTCTCCACAATCTGATAGAAACTCATCTTCTACAATGGTAAAAAGAGAAAGGATTGTAAATGCCAGTGTAATTA
TAACATTTATGAATGAATTTTCTTGCAGAATATAGAGAATGTTTATATGGAATCAGAATCAGTACCTTATCTTCACTGAACATCTGAATA

>100757_100757_2_ZDHHC17-C10orf112_ZDHHC17_chr12_77158109_ENST00000426126_C10orf112_chr10_19546613_ENST00000454679_length(amino acids)=1323AA_BP=143
MSQPPGRLPRAARASHLPPAGTRPRAAGPTPRALRRPQRSAAERDPVWGRAALPRTRGETRALRGGRGQRGRHGGRRRRRRRPASPPAGL
ALAPRSPSASPEPREGETLSPSMQREEGFNTKMADGPDEYDTEAGCVPLLHPEILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLP
TPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGIS
IHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQ
WKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSS
GRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNG
IGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCP
LGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPI
RSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPNENTFGSSDHTNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSA
KATGSIQILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLKGPPQEKPNRRSALLSVGEISELC
PEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPG
SGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFK
VAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPC
STDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDTWTLLGIGLAFLMTHITVAV

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Fusion Gene PPI Analysis for ZDHHC17-C10orf112


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZDHHC17-C10orf112


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZDHHC17-C10orf112


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource