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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZDHHC17-NAV3 (FusionGDB2 ID:100767)

Fusion Gene Summary for ZDHHC17-NAV3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC17-NAV3
Fusion gene ID: 100767
HgeneTgene
Gene symbol

ZDHHC17

NAV3

Gene ID

23390

89795

Gene namezinc finger DHHC-type palmitoyltransferase 17neuron navigator 3
SynonymsDHHC-17|HIP14|HIP3|HSPC294|HYPHPOMFIL1|STEERIN3|unc53H3
Cytomap

12q21.2

12q21.2

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC17huntingtin interacting protein 14huntingtin interacting protein 3huntingtin yeast partner Hhuntingtin-interacting protein Hputative MAPK-activating protein PM11putative NF-kappa-B-activating protein 205zinc finger DHHC dneuron navigator 3pore membrane and/or filament interacting like protein 1unc-53 homolog 3
Modification date2020031320200313
UniProtAcc.

Q8IVL0

Ensembl transtripts involved in fusion geneENST00000334822, ENST00000359019, 
ENST00000426126, ENST00000550789, 
ENST00000228327, ENST00000266692, 
ENST00000541270, ENST00000552300, 
ENST00000397909, ENST00000536525, 
Fusion gene scores* DoF score19 X 6 X 9=102622 X 21 X 4=1848
# samples 2220
** MAII scorelog2(22/1026*10)=-2.22145530208239
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1848*10)=-3.20789285164133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZDHHC17 [Title/Abstract] AND NAV3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZDHHC17(77158109)-NAV3(78540149), # samples:3
Anticipated loss of major functional domain due to fusion event.ZDHHC17-NAV3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZDHHC17-NAV3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZDHHC17

GO:0018345

protein palmitoylation

23034182

HgeneZDHHC17

GO:0042953

lipoprotein transport

15603740


check buttonFusion gene breakpoints across ZDHHC17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NAV3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A2J0-01AZDHHC17chr12

77158109

-NAV3chr12

78540149

+
ChimerDB4SARCTCGA-DX-A2J0-01AZDHHC17chr12

77158109

+NAV3chr12

78540149

+


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Fusion Gene ORF analysis for ZDHHC17-NAV3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334822ENST00000228327ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000334822ENST00000266692ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000334822ENST00000541270ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000334822ENST00000552300ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000359019ENST00000228327ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000359019ENST00000266692ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000359019ENST00000541270ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000359019ENST00000552300ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000426126ENST00000228327ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000426126ENST00000266692ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000426126ENST00000541270ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
5CDS-intronENST00000426126ENST00000552300ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
Frame-shiftENST00000359019ENST00000397909ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
Frame-shiftENST00000359019ENST00000536525ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
In-frameENST00000334822ENST00000397909ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
In-frameENST00000334822ENST00000536525ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
In-frameENST00000426126ENST00000397909ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
In-frameENST00000426126ENST00000536525ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
intron-3CDSENST00000550789ENST00000397909ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
intron-3CDSENST00000550789ENST00000536525ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
intron-intronENST00000550789ENST00000228327ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
intron-intronENST00000550789ENST00000266692ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
intron-intronENST00000550789ENST00000541270ZDHHC17chr12

77158109

+NAV3chr12

78540149

+
intron-intronENST00000550789ENST00000552300ZDHHC17chr12

77158109

+NAV3chr12

78540149

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334822ZDHHC17chr1277158109+ENST00000536525NAV3chr1278540149+32727423133150945
ENST00000334822ZDHHC17chr1277158109+ENST00000397909NAV3chr1278540149+57077423133216967
ENST00000426126ZDHHC17chr1277158109+ENST00000536525NAV3chr1278540149+32727423133150945
ENST00000426126ZDHHC17chr1277158109+ENST00000397909NAV3chr1278540149+57077423133216967

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334822ENST00000536525ZDHHC17chr1277158109+NAV3chr1278540149+0.0017638960.99823606
ENST00000334822ENST00000397909ZDHHC17chr1277158109+NAV3chr1278540149+0.0004677350.99953234
ENST00000426126ENST00000536525ZDHHC17chr1277158109+NAV3chr1278540149+0.0017638960.99823606
ENST00000426126ENST00000397909ZDHHC17chr1277158109+NAV3chr1278540149+0.0004677350.99953234

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Fusion Genomic Features for ZDHHC17-NAV3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZDHHC17chr1277158109+NAV3chr1278540148+1.25E-070.9999999
ZDHHC17chr1277158109+NAV3chr1278540148+1.25E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZDHHC17-NAV3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:77158109/chr12:78540149)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NAV3

Q8IVL0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May regulate IL2 production by T-cells. May be involved in neuron regeneration. {ECO:0000269|PubMed:16166283}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNAV3chr12:77158109chr12:78540149ENST0000039790919401562_165315612386.0Coiled coilOntology_term=ECO:0000255
TgeneNAV3chr12:77158109chr12:78540149ENST0000039790919401794_186115612386.0Coiled coilOntology_term=ECO:0000255
TgeneNAV3chr12:77158109chr12:78540149ENST0000053652519391562_165315612364.0Coiled coilOntology_term=ECO:0000255
TgeneNAV3chr12:77158109chr12:78540149ENST0000053652519391794_186115612364.0Coiled coilOntology_term=ECO:0000255
TgeneNAV3chr12:77158109chr12:78540149ENST0000039790919401694_169915612386.0Compositional biasNote=Poly-Lys
TgeneNAV3chr12:77158109chr12:78540149ENST0000039790919401867_188515612386.0Compositional biasNote=Ser-rich
TgeneNAV3chr12:77158109chr12:78540149ENST0000053652519391694_169915612364.0Compositional biasNote=Poly-Lys
TgeneNAV3chr12:77158109chr12:78540149ENST0000053652519391867_188515612364.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117437_48731633.0DomainDHHC
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17437_48715217.0DomainDHHC
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117437_48731633.0DomainDHHC
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117123_15231633.0RepeatANK 3
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117156_18531633.0RepeatANK 4
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117189_21931633.0RepeatANK 5
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117224_25331633.0RepeatANK 6
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117257_28631633.0RepeatANK 7
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+11751_8631633.0RepeatANK 1
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+11789_11831633.0RepeatANK 2
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17123_15215217.0RepeatANK 3
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17156_18515217.0RepeatANK 4
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17189_21915217.0RepeatANK 5
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17224_25315217.0RepeatANK 6
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17257_28615217.0RepeatANK 7
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+1751_8615217.0RepeatANK 1
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+1789_11815217.0RepeatANK 2
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117123_15231633.0RepeatANK 3
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117156_18531633.0RepeatANK 4
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117189_21931633.0RepeatANK 5
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117224_25331633.0RepeatANK 6
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117257_28631633.0RepeatANK 7
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+11751_8631633.0RepeatANK 1
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+11789_11831633.0RepeatANK 2
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+1171_30431633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117347_35731633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117379_38131633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117403_48031633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117502_52931633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117551_63231633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+171_30415217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17347_35715217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17379_38115217.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17403_48015217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17502_52915217.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17551_63215217.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+1171_30431633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117347_35731633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117379_38131633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117403_48031633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117502_52931633.0Topological domainLumenal
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117551_63231633.0Topological domainCytoplasmic
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117305_32531633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117326_34631633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117358_37831633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117382_40231633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117481_50131633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000334822+117530_55031633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17305_32515217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17326_34615217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17358_37815217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17382_40215217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17481_50115217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000359019+17530_55015217.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117305_32531633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117326_34631633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117358_37831633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117382_40231633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117481_50131633.0TransmembraneHelical
HgeneZDHHC17chr12:77158109chr12:78540149ENST00000426126+117530_55031633.0TransmembraneHelical
TgeneNAV3chr12:77158109chr12:78540149ENST000003979091940679_70715612386.0Coiled coilOntology_term=ECO:0000255
TgeneNAV3chr12:77158109chr12:78540149ENST000005365251939679_70715612364.0Coiled coilOntology_term=ECO:0000255
TgeneNAV3chr12:77158109chr12:78540149ENST0000039790919401032_156015612386.0Compositional biasNote=Ser-rich
TgeneNAV3chr12:77158109chr12:78540149ENST000003979091940618_62115612386.0Compositional biasNote=Poly-Gln
TgeneNAV3chr12:77158109chr12:78540149ENST0000053652519391032_156015612364.0Compositional biasNote=Ser-rich
TgeneNAV3chr12:77158109chr12:78540149ENST000005365251939618_62115612364.0Compositional biasNote=Poly-Gln
TgeneNAV3chr12:77158109chr12:78540149ENST00000397909194077_18415612386.0DomainCalponin-homology (CH)
TgeneNAV3chr12:77158109chr12:78540149ENST00000536525193977_18415612364.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for ZDHHC17-NAV3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100767_100767_1_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000334822_NAV3_chr12_78540149_ENST00000397909_length(transcript)=5707nt_BP=742nt
TTGTATCCATGTTTTTCCGGGCGTCCCCCGGAGGGACAGGTTGCGGGTGACCTTTTCAAGTGTGGAGGAAAGGGAAGCTGCTTTTGTCTT
CAGGAATGATGCAGGTCTCGACTCAAGCCTGACGGGCCCAAACCTCCCTGGAGCTGGCTGACGACTCTGCCCGAGTTCCTGAAGAGGGGT
CCCGGGGGTCCCGGAGCGGAAGTGGGAGCGCGTGGGCGTGGGCTCCTCGGCTGCCTGGGGCTCCAGACTTGTGCTGCGTGCGGCTCCGGA
GCTCTGTTCTCGCTCCTGAGCAGCTGCTAGGTTTCCCAAGCGACTGTCTCAACCGCCCGGCCGCCTCCCCCGGGCAGCCAGAGCTTCACA
TCTACCTCCAGCCGGGACCCGCCCCCGAGCCGCGGGGCCCACGCCCAGAGCCCTCCGCCGTCCCCAGCGCAGTGCAGCAGAGCGCGATCC
AGTCTGGGGCCGGGCCGCGCTTCCGCGCACGCGCGGAGAAACCCGCGCCCTCCGAGGGGGGAGGGGACAGAGGGGGCGTCACGGGGGCAG
GAGAAGAAGGAGGAGGAGGCCCGCGTCGCCTCCGGCGGGGCTCGCGCTCGCCCCGCGCTCGCCCTCCGCCTCGCCCGAGCCCCGGGAGGG
TGAAACGCTTTCTCCCAGCATGCAGCGGGAGGAGGGATTTAACACCAAGATGGCGGACGGCCCGGATGAGTACGATACCGAAGCGGGCTG
TGTGCCCCTTCTCCACCCAGAGGCTGAAGAAAAGGCTCATTCAGAGCAAATCCATAAACTGCGGAGAGAGCTGGTTGCATCACAAGAAAA
AGTTGCTACCCTCACATCTCAGCTTTCAGCAAATGCTCACCTTGTAGCAGCTTTTGAAAAGAGCTTAGGGAATATGACTGGCCGATTGCA
AAGTCTAACTATGACAGCGGAACAAAAGGAATCTGAACTTATAGAACTAAGAGAAACCATTGAAATGCTGAAGGCTCAGAATTCTGCTGC
CCAGGCGGCTATTCAGGGAGCACTGAATGGTCCAGACCATCCTCCCAAAGATCTTCGCATCAGAAGACAGCATTCCTCTGAAAGTGTTTC
TAGTATCAACAGTGCCACAAGCCATTCCAGTATTGGCAGTGGTAATGATGCCGACTCCAAGAAGAAGAAAAAGAAAAACTGGGTGAACTC
TAGAGGAAGTGAGCTGAGAAGTTCTTTCAAACAAGCCTTTGGGAAGAAAAAGTCCACCAAGCCTCCTTCATCACATTCTGACATTGAAGA
GCTTACTGATTCATCCCTTCCGGCATCCCCCAAGTTACCCCATAATGCTGGTGACTGTGGCTCAGCATCCATGAAGCCCTCACAATCTGC
TTCAGCGTCACCCCTTGTCTGGCCACCAAAGAAACGACAAAATGGCCCTGTGATCTACAAGCATAGATCTCGGATCTGTGAATGCACAGA
AGCTGAGGCAGAGATAATTCTGCAGCTGAAGAGCGAGCTCAGAGAAAAGGAATTAAAATTAACGGATATTCGGCTGGAGGCCCTCAGCTC
TGCTCATCATCTTGATCAGATCCGGGAAGCCATGAACCGGATGCAGAATGAAATTGAAATACTGAAAGCTGAAAATGACCGGTTGAAGGC
AGAAACTGGTAACACAGCTAAGCCTACTCGGCCACCGTCAGAATCCTCAAGCAGCACCTCCTCTTCATCTTCCAGGCAGTCATTAGGACT
TTCTCTAAACAATTTGAACATCACAGAGGCTGTTAGCTCAGATATTTTGCTAGATGATGCTGGTGATGCAACTGGACATAAAGATGGCCG
CAGTGTGAAAATTATAGTCTCCATAAGCAAGGGCTATGGTCGAGCAAAGGACCAAAAATCTCAGGCATATTTGATAGGATCCATTGGTGT
TAGTGGAAAAACCAAGTGGGATGTCTTAGATGGTGTAATAAGACGTCTCTTTAAGGAATATGTATTCCGAATTGATACATCCACTAGCCT
TGGTCTGAGCTCTGACTGCATTGCTAGCTACTGTATAGGAGACTTAATTAGATCCCATAACCTAGAAGTGCCTGAATTGCTGCCTTGTGG
ATACCTTGTTGGAGATAATAACATCATCACTGTGAACCTCAAAGGGGTAGAAGAAAATAGTTTGGACAGTTTTGTTTTTGATACGCTGAT
TCCTAAACCAATTACCCAAAGGTACTTTAACTTGTTGATGGAGCATCACAGAATTATACTCTCAGGACCGAGTGGTACTGGAAAGACCTA
TTTGGCAAACAAACTTGCTGAATATGTAATAACCAAATCTGGAAGGAAAAAAACAGAGGATGCAATTGCCACTTTTAATGTGGACCACAA
GTCAAGTAAGGAATTGCAACAATATCTAGCTAACCTGGCTGAACAGTGCAGTGCTGATAATAATGGAGTGGAGCTCCCAGTTGTAATAAT
TCTTGATAATCTTCATCATGTGGGCTCTCTGAGTGATATCTTCAATGGTTTTCTCAATTGTAAATACAACAAATGTCCATATATTATTGG
AACAATGAATCAGGGAGTTTCTTCATCACCAAATCTAGAGCTGCATCACAATTTCAGGTGGGTATTATGTGCAAATCATACAGAACCAGT
GAAAGGCTTTTTAGGCAGATATCTTCGAAGAAAACTCATAGAGATAGAAATTGAAAGGAACATTCGCAATAATGACCTAGTCAAAATTAT
AGATTGGATTCCGAAGACGTGGCATCATCTCAACAGTTTTTTGGAAACACACAGTTCTTCTGACGTTACCATTGGTCCCCGACTATTCCT
TCCTTGCCCCATGGATGTAGAAGGTTCTAGAGTATGGTTCATGGATCTCTGGAACTATTCTTTAGTACCTTATATTCTGGAGGCAGTGAG
AGAGGGTCTTCAGATGTATGGGAAACGCACACCATGGGAAGATCCTTCAAAGTGGGTGCTTGACACATATCCATGGAGCTCAGCAACTCT
GCCTCAGGAGAGCCCAGCCTTACTTCAGCTGCGACCAGAAGATGTTGGGTATGAAAGCTGCACATCCACTAAGGAAGCCACAACCTCAAA
GCACATTCCGCAAACTGACACAGAAGGAGATCCCCTGATGAATATGCTAATGAAACTCCAAGAAGCAGCCAATTACTCGAGCACACAAAG
CTGCGACAGCGAAAGCACCAGCCACCATGAAGACATTTTGGATTCATCTCTTGAATCTACCCTCTAGAGGGTGAAAAAAGTTAAGGGAAA
AGACTTTGCTTTTAAAAAAATGTTTCAAAAGAAAGGTATTTTCACTAAACCACTGCCAGTATAAAAGCACCCTGTCAAGGGCCCTGACCC
AGAGTTGTGGTCTCCAAGGAGGCAGCAGAACTAAGTCTGAACCGCCAAGATGCTAAATTGCAATGGAAGCTTAACTTTAGTTTATTTCTA
AGCATTTTTTATATCTGTGGAGTAATAGAAAGCTCCATTACTCAACTGGAAAGGACCCTAATGACAGGGCAACTGAACAGATTGCACATG
GGATAGCCAAACTGGACTTTCTTTGTTTCCTCTTTAAAAGTTTACAATGCAGACCATTTTTTGTCCCTTCCTTTTGTTTCCTCTGAGGGG
CTGTTCGCCCCAGGCAGGGTCCATCTTTCTGATCTGTCCAACCTCCTTTGTGCCACACGGTGCTGGTCACAGGGCTTCAGTAGTGTTTGT
GTTGTGCGCTCACCCCATTCCAGAACAAATCCAAGAGGCCAGTCCTCCATAAGCACAAATGGAATTGTGCAACCACCAGAAAAACACTAC
TGTGGCAAACTGGAGAAGTGCCAATTTAATTCTAACTGCCACGTTCTCATGATGTGCTCCACCAACTTTTTAGTATATGAGTCACTGGTT
TTATAAGGTTGTTTTTACCACAGTGGTCTTTTTAAACCACCTGCCCACTCCCTTAACAAGAGTTTTATACCAATTATTAGTCAACACTGA
TAAAAGGCTTTTTTAGGGCTTTATTTGTTTGAGCCTTTTCAGTGAAAGAAGGAACATTTCCTATGGTGCTGTCTCACTGCCTTAAAACAG
ATTTCTATGACAGTTTAACAGTTGGTTTAAATCCTAAACCATTGGTAATTTCCACTGTCTTTTCATTTACAACCAAGCAACACCAGTTAA
CATAGTAGCCTCATCTCTATATATCTTTCTCTTTTTTTTTTTTTTGAAGAAATGGATAGGAGAAAGATCAGTATTTTTAGCCTTGTGAAT
AGATCGCTTTGCCTATCCTCCAAAATATTAAAATAACCCAGAAATGCTCTTTGACCGTCACTTAAAACCTAAGACATGTGGCGAAATTCC
ATCCAGTTCTAAGTGAAAGAGTTTCAGAAGGCAGAAGATTTTGAATTATTATCCAGCAGGGCTGGAAGCACTAGATGCAGCATGAGCACA
ACTATTCGGCTTTCCTTCCCTATTGTTTTTGTTTTTTTAATGAGTTTTGACGCATGTTGTTTTGATTGCTATTGTTGTACATGAGAAATT
CAGCATTAAAGAACACTGAAGCGGTAAGGTCACTGTGGAAGAGGAAGCGTTTATACTGTAAAAGAAGGTTAGATTTGCACAGTCTACTGG
GTAGGTATTGTAAATAATAATTTTTAAAACTTGCACAAATCAAAACAAACACAAACAAAATTGTATTTTATCCTGTTGGTGTTAAGAGGT
GTTTCACTTGCTGAGATTTCCTGTACATTGCAAACAAATACAGAATGCAAACCCTCAAAGCTGTATTATCTGGTGTGTTTGTCCTGTATT
TACAGTTGTTTTTGACTATGCAGGAGCTATCAGTGCTAGAGTGAGCATGCTTCAAAACTGTACATGAAGCCAATATATTTTTGGATAAGT
AAAACTGTCTGAAAGTACATCTGTCATGGCAGGCTTTAAAGAGAGTGCATGAAAACTGATCAGTCATTGGAGAAGTTACCACCACACACA
AAGGACAGGTTTTAAGTTTATGAAACCCAAGGGCTAGGCCATGGTATAGACTTCTTCTATGAGTGTGTGAAAATGTGTTACTTTTAGGAC
GTGTATTTGGTGCTACTCTCTGTGACCACCAATGGGTCAGTTGCTATAGAACAACAACACCACGAAACATCTGTGCAGTTTTCAGAGTGT
CACAAAGTCAATAGGTCCTTACACGGTGCTATTGCCCTAAGGGAAATCCGAACTGAATTTATGCACATAGAATTGTCACCCTGACTTTGA
AGCCTCAAACATGGATCAAATCTGTTGTGAAACATCAATATATGTAGCTGGATGAGTGACTAGTTTCCCTTGTATAATATGTGATCTAAG
AAAATTGCTAATCTTTCCCTGCCATTTTGAGAAACACAGTCCAAACATGAGCATAAACAGAATTTCCTGCAATACATCCCAGTAGGTCCA
CCTAGTTTACAACTTAAACTAGTTTGTGAAACATTTGTCTGTATACATTTTATATTTTGTACATTTTGATGTAACATATCATGTAAATAG
GCAGAAACAGTGAAATAAATCATCTGAAAAGTTTTGTAGTCTTTGTAAAGCCCCAACAATAAGTACTTGGTGTCAATGGACTTAACTGGA
TGATGTATTTTCTATTGGTTTATTGTTCCTCTAGCTTGTAAACCAGCTTGCATATATTTTTTTGCAAATGTGCACCCTGTATCTGTCTAA

>100767_100767_1_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000334822_NAV3_chr12_78540149_ENST00000397909_length(amino acids)=967AA_BP=1
MSQPPGRLPRAARASHLPPAGTRPRAAGPTPRALRRPQRSAAERDPVWGRAALPRTRGETRALRGGRGQRGRHGGRRRRRRRPASPPAGL
ALAPRSPSASPEPREGETLSPSMQREEGFNTKMADGPDEYDTEAGCVPLLHPEAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHL
VAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSG
NDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQN
GPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPTRPPSE
SSSSTSSSSSRQSLGLSLNNLNITEAVSSDILLDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIR
RLFKEYVFRIDTSTSLGLSSDCIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLME
HHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIF
NGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFL
ETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPED

--------------------------------------------------------------
>100767_100767_2_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000334822_NAV3_chr12_78540149_ENST00000536525_length(transcript)=3272nt_BP=742nt
TTGTATCCATGTTTTTCCGGGCGTCCCCCGGAGGGACAGGTTGCGGGTGACCTTTTCAAGTGTGGAGGAAAGGGAAGCTGCTTTTGTCTT
CAGGAATGATGCAGGTCTCGACTCAAGCCTGACGGGCCCAAACCTCCCTGGAGCTGGCTGACGACTCTGCCCGAGTTCCTGAAGAGGGGT
CCCGGGGGTCCCGGAGCGGAAGTGGGAGCGCGTGGGCGTGGGCTCCTCGGCTGCCTGGGGCTCCAGACTTGTGCTGCGTGCGGCTCCGGA
GCTCTGTTCTCGCTCCTGAGCAGCTGCTAGGTTTCCCAAGCGACTGTCTCAACCGCCCGGCCGCCTCCCCCGGGCAGCCAGAGCTTCACA
TCTACCTCCAGCCGGGACCCGCCCCCGAGCCGCGGGGCCCACGCCCAGAGCCCTCCGCCGTCCCCAGCGCAGTGCAGCAGAGCGCGATCC
AGTCTGGGGCCGGGCCGCGCTTCCGCGCACGCGCGGAGAAACCCGCGCCCTCCGAGGGGGGAGGGGACAGAGGGGGCGTCACGGGGGCAG
GAGAAGAAGGAGGAGGAGGCCCGCGTCGCCTCCGGCGGGGCTCGCGCTCGCCCCGCGCTCGCCCTCCGCCTCGCCCGAGCCCCGGGAGGG
TGAAACGCTTTCTCCCAGCATGCAGCGGGAGGAGGGATTTAACACCAAGATGGCGGACGGCCCGGATGAGTACGATACCGAAGCGGGCTG
TGTGCCCCTTCTCCACCCAGAGGCTGAAGAAAAGGCTCATTCAGAGCAAATCCATAAACTGCGGAGAGAGCTGGTTGCATCACAAGAAAA
AGTTGCTACCCTCACATCTCAGCTTTCAGCAAATGCTCACCTTGTAGCAGCTTTTGAAAAGAGCTTAGGGAATATGACTGGCCGATTGCA
AAGTCTAACTATGACAGCGGAACAAAAGGAATCTGAACTTATAGAACTAAGAGAAACCATTGAAATGCTGAAGGCTCAGAATTCTGCTGC
CCAGGCGGCTATTCAGGGAGCACTGAATGGTCCAGACCATCCTCCCAAAGATCTTCGCATCAGAAGACAGCATTCCTCTGAAAGTGTTTC
TAGTATCAACAGTGCCACAAGCCATTCCAGTATTGGCAGTGGTAATGATGCCGACTCCAAGAAGAAGAAAAAGAAAAACTGGGTGAACTC
TAGAGGAAGTGAGCTGAGAAGTTCTTTCAAACAAGCCTTTGGGAAGAAAAAGTCCACCAAGCCTCCTTCATCACATTCTGACATTGAAGA
GCTTACTGATTCATCCCTTCCGGCATCCCCCAAGTTACCCCATAATGCTGGTGACTGTGGCTCAGCATCCATGAAGCCCTCACAATCTGC
TTCAGCGATCTGTGAATGCACAGAAGCTGAGGCAGAGATAATTCTGCAGCTGAAGAGCGAGCTCAGAGAAAAGGAATTAAAATTAACGGA
TATTCGGCTGGAGGCCCTCAGCTCTGCTCATCATCTTGATCAGATCCGGGAAGCCATGAACCGGATGCAGAATGAAATTGAAATACTGAA
AGCTGAAAATGACCGGTTGAAGGCAGAAACTGGTAACACAGCTAAGCCTACTCGGCCACCGTCAGAATCCTCAAGCAGCACCTCCTCTTC
ATCTTCCAGGCAGTCATTAGGACTTTCTCTAAACAATTTGAACATCACAGAGGCTGTTAGCTCAGATATTTTGCTAGATGATGCTGGTGA
TGCAACTGGACATAAAGATGGCCGCAGTGTGAAAATTATAGTCTCCATAAGCAAGGGCTATGGTCGAGCAAAGGACCAAAAATCTCAGGC
ATATTTGATAGGATCCATTGGTGTTAGTGGAAAAACCAAGTGGGATGTCTTAGATGGTGTAATAAGACGTCTCTTTAAGGAATATGTATT
CCGAATTGATACATCCACTAGCCTTGGTCTGAGCTCTGACTGCATTGCTAGCTACTGTATAGGAGACTTAATTAGATCCCATAACCTAGA
AGTGCCTGAATTGCTGCCTTGTGGATACCTTGTTGGAGATAATAACATCATCACTGTGAACCTCAAAGGGGTAGAAGAAAATAGTTTGGA
CAGTTTTGTTTTTGATACGCTGATTCCTAAACCAATTACCCAAAGGTACTTTAACTTGTTGATGGAGCATCACAGAATTATACTCTCAGG
ACCGAGTGGTACTGGAAAGACCTATTTGGCAAACAAACTTGCTGAATATGTAATAACCAAATCTGGAAGGAAAAAAACAGAGGATGCAAT
TGCCACTTTTAATGTGGACCACAAGTCAAGTAAGGAATTGCAACAATATCTAGCTAACCTGGCTGAACAGTGCAGTGCTGATAATAATGG
AGTGGAGCTCCCAGTTGTAATAATTCTTGATAATCTTCATCATGTGGGCTCTCTGAGTGATATCTTCAATGGTTTTCTCAATTGTAAATA
CAACAAATGTCCATATATTATTGGAACAATGAATCAGGGAGTTTCTTCATCACCAAATCTAGAGCTGCATCACAATTTCAGGTGGGTATT
ATGTGCAAATCATACAGAACCAGTGAAAGGCTTTTTAGGCAGATATCTTCGAAGAAAACTCATAGAGATAGAAATTGAAAGGAACATTCG
CAATAATGACCTAGTCAAAATTATAGATTGGATTCCGAAGACGTGGCATCATCTCAACAGTTTTTTGGAAACACACAGTTCTTCTGACGT
TACCATTGGTCCCCGACTATTCCTTCCTTGCCCCATGGATGTAGAAGGTTCTAGAGTATGGTTCATGGATCTCTGGAACTATTCTTTAGT
ACCTTATATTCTGGAGGCAGTGAGAGAGGGTCTTCAGATGTATGGGAAACGCACACCATGGGAAGATCCTTCAAAGTGGGTGCTTGACAC
ATATCCATGGAGCTCAGCAACTCTGCCTCAGGAGAGCCCAGCCTTACTTCAGCTGCGACCAGAAGATGTTGGGTATGAAAGCTGCACATC
CACTAAGGAAGCCACAACCTCAAAGCACATTCCGCAAACTGACACAGAAGGAGATCCCCTGATGAATATGCTAATGAAACTCCAAGAAGC
AGCCAATTACTCGAGCACACAAAGCTGCGACAGCGAAAGCACCAGCCACCATGAAGACATTTTGGATTCATCTCTTGAATCTACCCTCTA
GAGGGTGAAAAAAGTTAAGGGAAAAGACTTTGCTTTTAAAAAAATGTTTCAAAAGAAAGGTATTTTCACTAAACCACTGCCAGTATAAAA

>100767_100767_2_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000334822_NAV3_chr12_78540149_ENST00000536525_length(amino acids)=945AA_BP=1
MSQPPGRLPRAARASHLPPAGTRPRAAGPTPRALRRPQRSAAERDPVWGRAALPRTRGETRALRGGRGQRGRHGGRRRRRRRPASPPAGL
ALAPRSPSASPEPREGETLSPSMQREEGFNTKMADGPDEYDTEAGCVPLLHPEAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHL
VAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSG
NDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASAICECTEAEAEII
LQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPTRPPSESSSSTSSSSSRQSLGLSLNNLN
ITEAVSSDILLDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSDC
IASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLANKLA
EYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGV
SSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDV
EGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTD

--------------------------------------------------------------
>100767_100767_3_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000426126_NAV3_chr12_78540149_ENST00000397909_length(transcript)=5707nt_BP=742nt
TTGTATCCATGTTTTTCCGGGCGTCCCCCGGAGGGACAGGTTGCGGGTGACCTTTTCAAGTGTGGAGGAAAGGGAAGCTGCTTTTGTCTT
CAGGAATGATGCAGGTCTCGACTCAAGCCTGACGGGCCCAAACCTCCCTGGAGCTGGCTGACGACTCTGCCCGAGTTCCTGAAGAGGGGT
CCCGGGGGTCCCGGAGCGGAAGTGGGAGCGCGTGGGCGTGGGCTCCTCGGCTGCCTGGGGCTCCAGACTTGTGCTGCGTGCGGCTCCGGA
GCTCTGTTCTCGCTCCTGAGCAGCTGCTAGGTTTCCCAAGCGACTGTCTCAACCGCCCGGCCGCCTCCCCCGGGCAGCCAGAGCTTCACA
TCTACCTCCAGCCGGGACCCGCCCCCGAGCCGCGGGGCCCACGCCCAGAGCCCTCCGCCGTCCCCAGCGCAGTGCAGCAGAGCGCGATCC
AGTCTGGGGCCGGGCCGCGCTTCCGCGCACGCGCGGAGAAACCCGCGCCCTCCGAGGGGGGAGGGGACAGAGGGGGCGTCACGGGGGCAG
GAGAAGAAGGAGGAGGAGGCCCGCGTCGCCTCCGGCGGGGCTCGCGCTCGCCCCGCGCTCGCCCTCCGCCTCGCCCGAGCCCCGGGAGGG
TGAAACGCTTTCTCCCAGCATGCAGCGGGAGGAGGGATTTAACACCAAGATGGCGGACGGCCCGGATGAGTACGATACCGAAGCGGGCTG
TGTGCCCCTTCTCCACCCAGAGGCTGAAGAAAAGGCTCATTCAGAGCAAATCCATAAACTGCGGAGAGAGCTGGTTGCATCACAAGAAAA
AGTTGCTACCCTCACATCTCAGCTTTCAGCAAATGCTCACCTTGTAGCAGCTTTTGAAAAGAGCTTAGGGAATATGACTGGCCGATTGCA
AAGTCTAACTATGACAGCGGAACAAAAGGAATCTGAACTTATAGAACTAAGAGAAACCATTGAAATGCTGAAGGCTCAGAATTCTGCTGC
CCAGGCGGCTATTCAGGGAGCACTGAATGGTCCAGACCATCCTCCCAAAGATCTTCGCATCAGAAGACAGCATTCCTCTGAAAGTGTTTC
TAGTATCAACAGTGCCACAAGCCATTCCAGTATTGGCAGTGGTAATGATGCCGACTCCAAGAAGAAGAAAAAGAAAAACTGGGTGAACTC
TAGAGGAAGTGAGCTGAGAAGTTCTTTCAAACAAGCCTTTGGGAAGAAAAAGTCCACCAAGCCTCCTTCATCACATTCTGACATTGAAGA
GCTTACTGATTCATCCCTTCCGGCATCCCCCAAGTTACCCCATAATGCTGGTGACTGTGGCTCAGCATCCATGAAGCCCTCACAATCTGC
TTCAGCGTCACCCCTTGTCTGGCCACCAAAGAAACGACAAAATGGCCCTGTGATCTACAAGCATAGATCTCGGATCTGTGAATGCACAGA
AGCTGAGGCAGAGATAATTCTGCAGCTGAAGAGCGAGCTCAGAGAAAAGGAATTAAAATTAACGGATATTCGGCTGGAGGCCCTCAGCTC
TGCTCATCATCTTGATCAGATCCGGGAAGCCATGAACCGGATGCAGAATGAAATTGAAATACTGAAAGCTGAAAATGACCGGTTGAAGGC
AGAAACTGGTAACACAGCTAAGCCTACTCGGCCACCGTCAGAATCCTCAAGCAGCACCTCCTCTTCATCTTCCAGGCAGTCATTAGGACT
TTCTCTAAACAATTTGAACATCACAGAGGCTGTTAGCTCAGATATTTTGCTAGATGATGCTGGTGATGCAACTGGACATAAAGATGGCCG
CAGTGTGAAAATTATAGTCTCCATAAGCAAGGGCTATGGTCGAGCAAAGGACCAAAAATCTCAGGCATATTTGATAGGATCCATTGGTGT
TAGTGGAAAAACCAAGTGGGATGTCTTAGATGGTGTAATAAGACGTCTCTTTAAGGAATATGTATTCCGAATTGATACATCCACTAGCCT
TGGTCTGAGCTCTGACTGCATTGCTAGCTACTGTATAGGAGACTTAATTAGATCCCATAACCTAGAAGTGCCTGAATTGCTGCCTTGTGG
ATACCTTGTTGGAGATAATAACATCATCACTGTGAACCTCAAAGGGGTAGAAGAAAATAGTTTGGACAGTTTTGTTTTTGATACGCTGAT
TCCTAAACCAATTACCCAAAGGTACTTTAACTTGTTGATGGAGCATCACAGAATTATACTCTCAGGACCGAGTGGTACTGGAAAGACCTA
TTTGGCAAACAAACTTGCTGAATATGTAATAACCAAATCTGGAAGGAAAAAAACAGAGGATGCAATTGCCACTTTTAATGTGGACCACAA
GTCAAGTAAGGAATTGCAACAATATCTAGCTAACCTGGCTGAACAGTGCAGTGCTGATAATAATGGAGTGGAGCTCCCAGTTGTAATAAT
TCTTGATAATCTTCATCATGTGGGCTCTCTGAGTGATATCTTCAATGGTTTTCTCAATTGTAAATACAACAAATGTCCATATATTATTGG
AACAATGAATCAGGGAGTTTCTTCATCACCAAATCTAGAGCTGCATCACAATTTCAGGTGGGTATTATGTGCAAATCATACAGAACCAGT
GAAAGGCTTTTTAGGCAGATATCTTCGAAGAAAACTCATAGAGATAGAAATTGAAAGGAACATTCGCAATAATGACCTAGTCAAAATTAT
AGATTGGATTCCGAAGACGTGGCATCATCTCAACAGTTTTTTGGAAACACACAGTTCTTCTGACGTTACCATTGGTCCCCGACTATTCCT
TCCTTGCCCCATGGATGTAGAAGGTTCTAGAGTATGGTTCATGGATCTCTGGAACTATTCTTTAGTACCTTATATTCTGGAGGCAGTGAG
AGAGGGTCTTCAGATGTATGGGAAACGCACACCATGGGAAGATCCTTCAAAGTGGGTGCTTGACACATATCCATGGAGCTCAGCAACTCT
GCCTCAGGAGAGCCCAGCCTTACTTCAGCTGCGACCAGAAGATGTTGGGTATGAAAGCTGCACATCCACTAAGGAAGCCACAACCTCAAA
GCACATTCCGCAAACTGACACAGAAGGAGATCCCCTGATGAATATGCTAATGAAACTCCAAGAAGCAGCCAATTACTCGAGCACACAAAG
CTGCGACAGCGAAAGCACCAGCCACCATGAAGACATTTTGGATTCATCTCTTGAATCTACCCTCTAGAGGGTGAAAAAAGTTAAGGGAAA
AGACTTTGCTTTTAAAAAAATGTTTCAAAAGAAAGGTATTTTCACTAAACCACTGCCAGTATAAAAGCACCCTGTCAAGGGCCCTGACCC
AGAGTTGTGGTCTCCAAGGAGGCAGCAGAACTAAGTCTGAACCGCCAAGATGCTAAATTGCAATGGAAGCTTAACTTTAGTTTATTTCTA
AGCATTTTTTATATCTGTGGAGTAATAGAAAGCTCCATTACTCAACTGGAAAGGACCCTAATGACAGGGCAACTGAACAGATTGCACATG
GGATAGCCAAACTGGACTTTCTTTGTTTCCTCTTTAAAAGTTTACAATGCAGACCATTTTTTGTCCCTTCCTTTTGTTTCCTCTGAGGGG
CTGTTCGCCCCAGGCAGGGTCCATCTTTCTGATCTGTCCAACCTCCTTTGTGCCACACGGTGCTGGTCACAGGGCTTCAGTAGTGTTTGT
GTTGTGCGCTCACCCCATTCCAGAACAAATCCAAGAGGCCAGTCCTCCATAAGCACAAATGGAATTGTGCAACCACCAGAAAAACACTAC
TGTGGCAAACTGGAGAAGTGCCAATTTAATTCTAACTGCCACGTTCTCATGATGTGCTCCACCAACTTTTTAGTATATGAGTCACTGGTT
TTATAAGGTTGTTTTTACCACAGTGGTCTTTTTAAACCACCTGCCCACTCCCTTAACAAGAGTTTTATACCAATTATTAGTCAACACTGA
TAAAAGGCTTTTTTAGGGCTTTATTTGTTTGAGCCTTTTCAGTGAAAGAAGGAACATTTCCTATGGTGCTGTCTCACTGCCTTAAAACAG
ATTTCTATGACAGTTTAACAGTTGGTTTAAATCCTAAACCATTGGTAATTTCCACTGTCTTTTCATTTACAACCAAGCAACACCAGTTAA
CATAGTAGCCTCATCTCTATATATCTTTCTCTTTTTTTTTTTTTTGAAGAAATGGATAGGAGAAAGATCAGTATTTTTAGCCTTGTGAAT
AGATCGCTTTGCCTATCCTCCAAAATATTAAAATAACCCAGAAATGCTCTTTGACCGTCACTTAAAACCTAAGACATGTGGCGAAATTCC
ATCCAGTTCTAAGTGAAAGAGTTTCAGAAGGCAGAAGATTTTGAATTATTATCCAGCAGGGCTGGAAGCACTAGATGCAGCATGAGCACA
ACTATTCGGCTTTCCTTCCCTATTGTTTTTGTTTTTTTAATGAGTTTTGACGCATGTTGTTTTGATTGCTATTGTTGTACATGAGAAATT
CAGCATTAAAGAACACTGAAGCGGTAAGGTCACTGTGGAAGAGGAAGCGTTTATACTGTAAAAGAAGGTTAGATTTGCACAGTCTACTGG
GTAGGTATTGTAAATAATAATTTTTAAAACTTGCACAAATCAAAACAAACACAAACAAAATTGTATTTTATCCTGTTGGTGTTAAGAGGT
GTTTCACTTGCTGAGATTTCCTGTACATTGCAAACAAATACAGAATGCAAACCCTCAAAGCTGTATTATCTGGTGTGTTTGTCCTGTATT
TACAGTTGTTTTTGACTATGCAGGAGCTATCAGTGCTAGAGTGAGCATGCTTCAAAACTGTACATGAAGCCAATATATTTTTGGATAAGT
AAAACTGTCTGAAAGTACATCTGTCATGGCAGGCTTTAAAGAGAGTGCATGAAAACTGATCAGTCATTGGAGAAGTTACCACCACACACA
AAGGACAGGTTTTAAGTTTATGAAACCCAAGGGCTAGGCCATGGTATAGACTTCTTCTATGAGTGTGTGAAAATGTGTTACTTTTAGGAC
GTGTATTTGGTGCTACTCTCTGTGACCACCAATGGGTCAGTTGCTATAGAACAACAACACCACGAAACATCTGTGCAGTTTTCAGAGTGT
CACAAAGTCAATAGGTCCTTACACGGTGCTATTGCCCTAAGGGAAATCCGAACTGAATTTATGCACATAGAATTGTCACCCTGACTTTGA
AGCCTCAAACATGGATCAAATCTGTTGTGAAACATCAATATATGTAGCTGGATGAGTGACTAGTTTCCCTTGTATAATATGTGATCTAAG
AAAATTGCTAATCTTTCCCTGCCATTTTGAGAAACACAGTCCAAACATGAGCATAAACAGAATTTCCTGCAATACATCCCAGTAGGTCCA
CCTAGTTTACAACTTAAACTAGTTTGTGAAACATTTGTCTGTATACATTTTATATTTTGTACATTTTGATGTAACATATCATGTAAATAG
GCAGAAACAGTGAAATAAATCATCTGAAAAGTTTTGTAGTCTTTGTAAAGCCCCAACAATAAGTACTTGGTGTCAATGGACTTAACTGGA
TGATGTATTTTCTATTGGTTTATTGTTCCTCTAGCTTGTAAACCAGCTTGCATATATTTTTTTGCAAATGTGCACCCTGTATCTGTCTAA

>100767_100767_3_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000426126_NAV3_chr12_78540149_ENST00000397909_length(amino acids)=967AA_BP=1
MSQPPGRLPRAARASHLPPAGTRPRAAGPTPRALRRPQRSAAERDPVWGRAALPRTRGETRALRGGRGQRGRHGGRRRRRRRPASPPAGL
ALAPRSPSASPEPREGETLSPSMQREEGFNTKMADGPDEYDTEAGCVPLLHPEAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHL
VAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSG
NDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQN
GPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPTRPPSE
SSSSTSSSSSRQSLGLSLNNLNITEAVSSDILLDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIR
RLFKEYVFRIDTSTSLGLSSDCIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLME
HHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIF
NGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFL
ETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPED

--------------------------------------------------------------
>100767_100767_4_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000426126_NAV3_chr12_78540149_ENST00000536525_length(transcript)=3272nt_BP=742nt
TTGTATCCATGTTTTTCCGGGCGTCCCCCGGAGGGACAGGTTGCGGGTGACCTTTTCAAGTGTGGAGGAAAGGGAAGCTGCTTTTGTCTT
CAGGAATGATGCAGGTCTCGACTCAAGCCTGACGGGCCCAAACCTCCCTGGAGCTGGCTGACGACTCTGCCCGAGTTCCTGAAGAGGGGT
CCCGGGGGTCCCGGAGCGGAAGTGGGAGCGCGTGGGCGTGGGCTCCTCGGCTGCCTGGGGCTCCAGACTTGTGCTGCGTGCGGCTCCGGA
GCTCTGTTCTCGCTCCTGAGCAGCTGCTAGGTTTCCCAAGCGACTGTCTCAACCGCCCGGCCGCCTCCCCCGGGCAGCCAGAGCTTCACA
TCTACCTCCAGCCGGGACCCGCCCCCGAGCCGCGGGGCCCACGCCCAGAGCCCTCCGCCGTCCCCAGCGCAGTGCAGCAGAGCGCGATCC
AGTCTGGGGCCGGGCCGCGCTTCCGCGCACGCGCGGAGAAACCCGCGCCCTCCGAGGGGGGAGGGGACAGAGGGGGCGTCACGGGGGCAG
GAGAAGAAGGAGGAGGAGGCCCGCGTCGCCTCCGGCGGGGCTCGCGCTCGCCCCGCGCTCGCCCTCCGCCTCGCCCGAGCCCCGGGAGGG
TGAAACGCTTTCTCCCAGCATGCAGCGGGAGGAGGGATTTAACACCAAGATGGCGGACGGCCCGGATGAGTACGATACCGAAGCGGGCTG
TGTGCCCCTTCTCCACCCAGAGGCTGAAGAAAAGGCTCATTCAGAGCAAATCCATAAACTGCGGAGAGAGCTGGTTGCATCACAAGAAAA
AGTTGCTACCCTCACATCTCAGCTTTCAGCAAATGCTCACCTTGTAGCAGCTTTTGAAAAGAGCTTAGGGAATATGACTGGCCGATTGCA
AAGTCTAACTATGACAGCGGAACAAAAGGAATCTGAACTTATAGAACTAAGAGAAACCATTGAAATGCTGAAGGCTCAGAATTCTGCTGC
CCAGGCGGCTATTCAGGGAGCACTGAATGGTCCAGACCATCCTCCCAAAGATCTTCGCATCAGAAGACAGCATTCCTCTGAAAGTGTTTC
TAGTATCAACAGTGCCACAAGCCATTCCAGTATTGGCAGTGGTAATGATGCCGACTCCAAGAAGAAGAAAAAGAAAAACTGGGTGAACTC
TAGAGGAAGTGAGCTGAGAAGTTCTTTCAAACAAGCCTTTGGGAAGAAAAAGTCCACCAAGCCTCCTTCATCACATTCTGACATTGAAGA
GCTTACTGATTCATCCCTTCCGGCATCCCCCAAGTTACCCCATAATGCTGGTGACTGTGGCTCAGCATCCATGAAGCCCTCACAATCTGC
TTCAGCGATCTGTGAATGCACAGAAGCTGAGGCAGAGATAATTCTGCAGCTGAAGAGCGAGCTCAGAGAAAAGGAATTAAAATTAACGGA
TATTCGGCTGGAGGCCCTCAGCTCTGCTCATCATCTTGATCAGATCCGGGAAGCCATGAACCGGATGCAGAATGAAATTGAAATACTGAA
AGCTGAAAATGACCGGTTGAAGGCAGAAACTGGTAACACAGCTAAGCCTACTCGGCCACCGTCAGAATCCTCAAGCAGCACCTCCTCTTC
ATCTTCCAGGCAGTCATTAGGACTTTCTCTAAACAATTTGAACATCACAGAGGCTGTTAGCTCAGATATTTTGCTAGATGATGCTGGTGA
TGCAACTGGACATAAAGATGGCCGCAGTGTGAAAATTATAGTCTCCATAAGCAAGGGCTATGGTCGAGCAAAGGACCAAAAATCTCAGGC
ATATTTGATAGGATCCATTGGTGTTAGTGGAAAAACCAAGTGGGATGTCTTAGATGGTGTAATAAGACGTCTCTTTAAGGAATATGTATT
CCGAATTGATACATCCACTAGCCTTGGTCTGAGCTCTGACTGCATTGCTAGCTACTGTATAGGAGACTTAATTAGATCCCATAACCTAGA
AGTGCCTGAATTGCTGCCTTGTGGATACCTTGTTGGAGATAATAACATCATCACTGTGAACCTCAAAGGGGTAGAAGAAAATAGTTTGGA
CAGTTTTGTTTTTGATACGCTGATTCCTAAACCAATTACCCAAAGGTACTTTAACTTGTTGATGGAGCATCACAGAATTATACTCTCAGG
ACCGAGTGGTACTGGAAAGACCTATTTGGCAAACAAACTTGCTGAATATGTAATAACCAAATCTGGAAGGAAAAAAACAGAGGATGCAAT
TGCCACTTTTAATGTGGACCACAAGTCAAGTAAGGAATTGCAACAATATCTAGCTAACCTGGCTGAACAGTGCAGTGCTGATAATAATGG
AGTGGAGCTCCCAGTTGTAATAATTCTTGATAATCTTCATCATGTGGGCTCTCTGAGTGATATCTTCAATGGTTTTCTCAATTGTAAATA
CAACAAATGTCCATATATTATTGGAACAATGAATCAGGGAGTTTCTTCATCACCAAATCTAGAGCTGCATCACAATTTCAGGTGGGTATT
ATGTGCAAATCATACAGAACCAGTGAAAGGCTTTTTAGGCAGATATCTTCGAAGAAAACTCATAGAGATAGAAATTGAAAGGAACATTCG
CAATAATGACCTAGTCAAAATTATAGATTGGATTCCGAAGACGTGGCATCATCTCAACAGTTTTTTGGAAACACACAGTTCTTCTGACGT
TACCATTGGTCCCCGACTATTCCTTCCTTGCCCCATGGATGTAGAAGGTTCTAGAGTATGGTTCATGGATCTCTGGAACTATTCTTTAGT
ACCTTATATTCTGGAGGCAGTGAGAGAGGGTCTTCAGATGTATGGGAAACGCACACCATGGGAAGATCCTTCAAAGTGGGTGCTTGACAC
ATATCCATGGAGCTCAGCAACTCTGCCTCAGGAGAGCCCAGCCTTACTTCAGCTGCGACCAGAAGATGTTGGGTATGAAAGCTGCACATC
CACTAAGGAAGCCACAACCTCAAAGCACATTCCGCAAACTGACACAGAAGGAGATCCCCTGATGAATATGCTAATGAAACTCCAAGAAGC
AGCCAATTACTCGAGCACACAAAGCTGCGACAGCGAAAGCACCAGCCACCATGAAGACATTTTGGATTCATCTCTTGAATCTACCCTCTA
GAGGGTGAAAAAAGTTAAGGGAAAAGACTTTGCTTTTAAAAAAATGTTTCAAAAGAAAGGTATTTTCACTAAACCACTGCCAGTATAAAA

>100767_100767_4_ZDHHC17-NAV3_ZDHHC17_chr12_77158109_ENST00000426126_NAV3_chr12_78540149_ENST00000536525_length(amino acids)=945AA_BP=1
MSQPPGRLPRAARASHLPPAGTRPRAAGPTPRALRRPQRSAAERDPVWGRAALPRTRGETRALRGGRGQRGRHGGRRRRRRRPASPPAGL
ALAPRSPSASPEPREGETLSPSMQREEGFNTKMADGPDEYDTEAGCVPLLHPEAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHL
VAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSG
NDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASAICECTEAEAEII
LQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPTRPPSESSSSTSSSSSRQSLGLSLNNLN
ITEAVSSDILLDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSDC
IASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLANKLA
EYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGV
SSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDV
EGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTD

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Fusion Gene PPI Analysis for ZDHHC17-NAV3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZDHHC17-NAV3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZDHHC17-NAV3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource