FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ZDHHC6-TCF7L2 (FusionGDB2 ID:100842)

Fusion Gene Summary for ZDHHC6-TCF7L2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC6-TCF7L2
Fusion gene ID: 100842
HgeneTgene
Gene symbol

ZDHHC6

TCF7L2

Gene ID

64429

6934

Gene namezinc finger DHHC-type palmitoyltransferase 6transcription factor 7 like 2
SynonymsDHHC-6|DHHC6|ZNF376TCF-4|TCF4
Cytomap

10q25.2

10q25.2-q25.3

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC6transmembrane protein H4zinc finger DHHC domain-containing protein 6zinc finger DHHC-type containing 6zinc finger protein 376transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)
Modification date2020031320200315
UniProtAcc.

Q9NQB0

Ensembl transtripts involved in fusion geneENST00000369404, ENST00000369405, 
ENST00000482410, 		ENST00000542695, 
ENST00000369386, ENST00000369389, 
ENST00000466338, ENST00000349937, 
ENST00000352065, ENST00000355717, 
ENST00000355995, ENST00000369395, 
ENST00000369397, ENST00000534894, 
ENST00000536810, ENST00000538897, 
ENST00000543371, ENST00000545257, 
Fusion gene scores* DoF score3 X 6 X 3=5412 X 11 X 10=1320
# samples 317
** MAII scorelog2(3/54*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1320*10)=-2.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZDHHC6 [Title/Abstract] AND TCF7L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZDHHC6(114194055)-TCF7L2(114900943), # samples:1
Anticipated loss of major functional domain due to fusion event.ZDHHC6-TCF7L2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ZDHHC6-TCF7L2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
ZDHHC6-TCF7L2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZDHHC6

GO:0018345

protein palmitoylation

22728137|23034182|25368151|28826475

TgeneTCF7L2

GO:0000122

negative regulation of transcription by RNA polymerase II

12799378

TgeneTCF7L2

GO:0006357

regulation of transcription by RNA polymerase II

9727977

TgeneTCF7L2

GO:0032092

positive regulation of protein binding

12799378

TgeneTCF7L2

GO:0032350

regulation of hormone metabolic process

15525634

TgeneTCF7L2

GO:0042593

glucose homeostasis

15525634

TgeneTCF7L2

GO:0043433

negative regulation of DNA-binding transcription factor activity

12799378

TgeneTCF7L2

GO:0045444

fat cell differentiation

10937998

TgeneTCF7L2

GO:0045892

negative regulation of transcription, DNA-templated

12799378|15525634

TgeneTCF7L2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065401|19168596

TgeneTCF7L2

GO:0048625

myoblast fate commitment

10937998


check buttonFusion gene breakpoints across ZDHHC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TCF7L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4449-01AZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+


Top

Fusion Gene ORF analysis for ZDHHC6-TCF7L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000369404ENST00000542695ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
5CDS-5UTRENST00000369405ENST00000542695ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
5CDS-intronENST00000369404ENST00000369386ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
5CDS-intronENST00000369404ENST00000369389ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
5CDS-intronENST00000369404ENST00000466338ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
5CDS-intronENST00000369405ENST00000369386ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
5CDS-intronENST00000369405ENST00000369389ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
5CDS-intronENST00000369405ENST00000466338ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000349937ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000352065ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000355717ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000355995ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000369395ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000369397ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000534894ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000536810ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000538897ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000543371ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369404ENST00000545257ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000349937ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000352065ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000355717ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000355995ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000369395ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000369397ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000534894ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000536810ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000538897ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000543371ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
Frame-shiftENST00000369405ENST00000545257ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000349937ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000352065ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000355717ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000355995ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000369395ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000369397ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000534894ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000536810ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000538897ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000543371ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-3CDSENST00000482410ENST00000545257ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-5UTRENST00000482410ENST00000542695ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-intronENST00000482410ENST00000369386ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-intronENST00000482410ENST00000369389ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+
intron-intronENST00000482410ENST00000466338ZDHHC6chr10

114194055

-TCF7L2chr10

114900943

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ZDHHC6-TCF7L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZDHHC6chr10114194054-TCF7L2chr10114900942+1.15E-050.99998844
ZDHHC6chr10114194054-TCF7L2chr10114900942+1.15E-050.99998844

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ZDHHC6-TCF7L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:114194055/:114900943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TCF7L2

Q9NQB0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ZDHHC6-TCF7L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ZDHHC6-TCF7L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ZDHHC6-TCF7L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ZDHHC6-TCF7L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource