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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFAND6-KLC1 (FusionGDB2 ID:100947)

Fusion Gene Summary for ZFAND6-KLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAND6-KLC1
Fusion gene ID: 100947
HgeneTgene
Gene symbol

ZFAND6

KLC1

Gene ID

54469

3831

Gene namezinc finger AN1-type containing 6kinesin light chain 1
SynonymsAWP1|ZA20D3|ZFAND5BKLC|KNS2|KNS2A
Cytomap

15q25.1

14q32.33

Type of geneprotein-codingprotein-coding
DescriptionAN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6kinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50
Modification date2020031320200313
UniProtAcc.

Q07866

Ensembl transtripts involved in fusion geneENST00000261749, ENST00000558494, 
ENST00000559157, ENST00000561060, 
ENST00000558087, ENST00000558688, 
ENST00000559775, ENST00000559835, 
ENST00000246489, ENST00000334553, 
ENST00000347839, ENST00000348520, 
ENST00000380038, ENST00000389744, 
ENST00000445352, ENST00000452929, 
ENST00000553286, ENST00000554280, 
ENST00000555836, ENST00000557450, 
ENST00000557575, 
Fusion gene scores* DoF score11 X 5 X 5=27520 X 16 X 10=3200
# samples 922
** MAII scorelog2(9/275*10)=-1.61143471208235
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/3200*10)=-3.86249647625007
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFAND6 [Title/Abstract] AND KLC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFAND6(80352151)-KLC1(104153417), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZFAND6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KLC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A2HXZFAND6chr15

80352151

+KLC1chr14

104153417

+


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Fusion Gene ORF analysis for ZFAND6-KLC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000261749ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000261749ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000558494ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000559157ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
5UTR-intronENST00000561060ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558087ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000558688ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559775ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000246489ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000334553ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000347839ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000348520ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000380038ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000389744ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000445352ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000452929ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000553286ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000554280ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000555836ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000557450ZFAND6chr15

80352151

+KLC1chr14

104153417

+
intron-intronENST00000559835ENST00000557575ZFAND6chr15

80352151

+KLC1chr14

104153417

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZFAND6-KLC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZFAND6chr1580352151+KLC1chr14104153417+0.0001591280.99984086
ZFAND6chr1580352151+KLC1chr14104153417+0.0001591280.99984086

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZFAND6-KLC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:80352151/:104153417)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KLC1

Q07866

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZFAND6-KLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZFAND6-KLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFAND6-KLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZFAND6-KLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource