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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFAND6-TRIM13 (FusionGDB2 ID:100953)

Fusion Gene Summary for ZFAND6-TRIM13

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAND6-TRIM13
Fusion gene ID: 100953
HgeneTgene
Gene symbol

ZFAND6

TRIM13

Gene ID

54469

10206

Gene namezinc finger AN1-type containing 6tripartite motif containing 13
SynonymsAWP1|ZA20D3|ZFAND5BCAR|DLEU5|LEU5|RFP2|RNF77
Cytomap

15q25.1

13q14.2

Type of geneprotein-codingprotein-coding
DescriptionAN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6E3 ubiquitin-protein ligase TRIM13B-cell chronic lymphocytic leukemia tumor suppressor Leu5CLL-associated RING fingerRING finger protein 77RING-type E3 ubiquitin transferase TRIM13leukemia-associated protein 5putative tumor suppressor RFP2ret finge
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261749, ENST00000559775, 
ENST00000558087, ENST00000558494, 
ENST00000558688, ENST00000559157, 
ENST00000559835, ENST00000561060, 
ENST00000478111, ENST00000298772, 
ENST00000356017, ENST00000378182, 
ENST00000420995, ENST00000457662, 
Fusion gene scores* DoF score11 X 5 X 5=2754 X 7 X 4=112
# samples 95
** MAII scorelog2(9/275*10)=-1.61143471208235
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/112*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFAND6 [Title/Abstract] AND TRIM13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFAND6(80390920)-TRIM13(50594350), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM13

GO:0010942

positive regulation of cell death

21333377

TgeneTRIM13

GO:0016239

positive regulation of macroautophagy

22178386

TgeneTRIM13

GO:0030433

ubiquitin-dependent ERAD pathway

17314412

TgeneTRIM13

GO:0032897

negative regulation of viral transcription

18248090

TgeneTRIM13

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

TgeneTRIM13

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

17314412

TgeneTRIM13

GO:0045087

innate immune response

18248090

TgeneTRIM13

GO:0051865

protein autoubiquitination

17314412

TgeneTRIM13

GO:1902187

negative regulation of viral release from host cell

18248090


check buttonFusion gene breakpoints across ZFAND6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRIM13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A2J6-06AZFAND6chr15

80390920

+TRIM13chr13

50594350

+


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Fusion Gene ORF analysis for ZFAND6-TRIM13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000261749ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-3UTRENST00000559775ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000261749ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
5UTR-intronENST00000559775ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000558087ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000558494ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000558688ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000559157ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000559835ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-3UTRENST00000561060ENST00000478111ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558087ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558494ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000558688ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559157ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000559835ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000298772ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000356017ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000378182ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000420995ZFAND6chr15

80390920

+TRIM13chr13

50594350

+
intron-intronENST00000561060ENST00000457662ZFAND6chr15

80390920

+TRIM13chr13

50594350

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZFAND6-TRIM13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZFAND6chr1580390920+TRIM13chr1350594349+9.46E-060.9999906
ZFAND6chr1580390920+TRIM13chr1350594349+9.46E-060.9999906

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZFAND6-TRIM13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:80390920/:50594350)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZFAND6-TRIM13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZFAND6-TRIM13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFAND6-TRIM13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZFAND6-TRIM13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource