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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFHX3-ZMAT4 (FusionGDB2 ID:101001)

Fusion Gene Summary for ZFHX3-ZMAT4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFHX3-ZMAT4
Fusion gene ID: 101001
HgeneTgene
Gene symbol

ZFHX3

ZMAT4

Gene ID

463

79698

Gene namezinc finger homeobox 3zinc finger matrin-type 4
SynonymsATBF1|ATBT|C16orf47|ZFH-3|ZNF927-
Cytomap

16q22.2-q22.3

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionzinc finger homeobox protein 3AT motif-binding factor 1AT-binding transcription factor 1alpha-fetoprotein enhancer binding proteinzinc finger homeodomain protein 3zinc finger matrin-type protein 4
Modification date2020031320200313
UniProtAcc

Q15911

.
Ensembl transtripts involved in fusion geneENST00000268489, ENST00000397992, 
ENST00000558842, 		ENST00000523823, 
ENST00000297737, ENST00000315769, 
Fusion gene scores* DoF score13 X 13 X 7=118315 X 12 X 7=1260
# samples 1917
** MAII scorelog2(19/1183*10)=-2.63837875000884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1260*10)=-2.88981708224958
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFHX3 [Title/Abstract] AND ZMAT4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFHX3(72845476)-ZMAT4(40438780), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFHX3

GO:0000122

negative regulation of transcription by RNA polymerase II

11314020

HgeneZFHX3

GO:0045893

positive regulation of transcription, DNA-templated

20599712

HgeneZFHX3

GO:0071559

response to transforming growth factor beta

20599712


check buttonFusion gene breakpoints across ZFHX3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZMAT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-7522-01AZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
ChimerDB4PRADTCGA-G9-7522ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-


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Fusion Gene ORF analysis for ZFHX3-ZMAT4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000268489ENST00000523823ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
5CDS-intronENST00000397992ENST00000523823ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
In-frameENST00000268489ENST00000297737ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
In-frameENST00000268489ENST00000315769ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
In-frameENST00000397992ENST00000297737ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
In-frameENST00000397992ENST00000315769ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
intron-3CDSENST00000558842ENST00000297737ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
intron-3CDSENST00000558842ENST00000315769ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
intron-intronENST00000558842ENST00000523823ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268489ZFHX3chr1672845476-ENST00000315769ZMAT4chr840438780-6283453767345421289
ENST00000268489ZFHX3chr1672845476-ENST00000297737ZMAT4chr840438780-6279453767345421289
ENST00000397992ZFHX3chr1672845476-ENST00000315769ZMAT4chr840438780-4060231411382319393
ENST00000397992ZFHX3chr1672845476-ENST00000297737ZMAT4chr840438780-4056231411382319393

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268489ENST00000315769ZFHX3chr1672845476-ZMAT4chr840438780-0.0034011950.9965988
ENST00000268489ENST00000297737ZFHX3chr1672845476-ZMAT4chr840438780-0.0034144010.9965856
ENST00000397992ENST00000315769ZFHX3chr1672845476-ZMAT4chr840438780-0.0041413750.9958586
ENST00000397992ENST00000297737ZFHX3chr1672845476-ZMAT4chr840438780-0.0041780620.99582195

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Fusion Genomic Features for ZFHX3-ZMAT4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZFHX3-ZMAT4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:72845476/chr8:40438780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFHX3

Q15911

.
FUNCTION: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710104_10712883704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710460_48912883704.0Compositional biasNote=Poly-Glu
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710770_78412883704.0Compositional biasNote=Poly-Ala
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69104_1073742790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101040_106412883704.0Zinc fingerC2H2-type 9%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101088_111212883704.0Zinc fingerC2H2-type 10%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101223_124612883704.0Zinc fingerC2H2-type 11%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101252_127512883704.0Zinc fingerC2H2-type 12
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710282_30512883704.0Zinc fingerC2H2-type 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710640_66312883704.0Zinc fingerC2H2-type 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710671_69412883704.0Zinc fingerC2H2-type 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710726_75012883704.0Zinc fingerC2H2-type 5
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-71079_10112883704.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710804_82812883704.0Zinc fingerC2H2-type 6%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710945_96812883704.0Zinc fingerC2H2-type 7%3B degenerate
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710984_100812883704.0Zinc fingerC2H2-type 8%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69282_3053742790.0Zinc fingerC2H2-type 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-6979_1013742790.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZMAT4chr16:72845476chr8:40438780ENST0000029773747198_228192230.0Zinc fingerNote=Matrin-type 4
TgeneZMAT4chr16:72845476chr8:40438780ENST0000031576936145_175116154.0Zinc fingerNote=Matrin-type 3
TgeneZMAT4chr16:72845476chr8:40438780ENST0000031576936198_228116154.0Zinc fingerNote=Matrin-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101723_174312883704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101789_179412883704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101852_185712883704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102037_205212883704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103197_320912883704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103210_321412883704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103227_323112883704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103376_338912883704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103392_339512883704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103507_352712883704.0Compositional biasNote=Poly-Gly
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103597_360012883704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103636_363912883704.0Compositional biasNote=Poly-Ser
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691723_17433742790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691789_17943742790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691852_18573742790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692037_20523742790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693197_32093742790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693210_32143742790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693227_32313742790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693376_33893742790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693392_33953742790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693507_35273742790.0Compositional biasNote=Poly-Gly
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693597_36003742790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693636_36393742790.0Compositional biasNote=Poly-Ser
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69460_4893742790.0Compositional biasNote=Poly-Glu
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69770_7843742790.0Compositional biasNote=Poly-Ala
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102145_220412883704.0DNA bindingHomeobox 1
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102242_230112883704.0DNA bindingHomeobox 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102641_270012883704.0DNA bindingHomeobox 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102944_300312883704.0DNA bindingHomeobox 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692145_22043742790.0DNA bindingHomeobox 1
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692242_23013742790.0DNA bindingHomeobox 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692641_27003742790.0DNA bindingHomeobox 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692944_30033742790.0DNA bindingHomeobox 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101360_138512883704.0Zinc fingerC2H2-type 13
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101401_142312883704.0Zinc fingerC2H2-type 14
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101429_145212883704.0Zinc fingerC2H2-type 15
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101545_156912883704.0Zinc fingerC2H2-type 16
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101596_162012883704.0Zinc fingerC2H2-type 17
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101983_200612883704.0Zinc fingerC2H2-type 18
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102328_235112883704.0Zinc fingerC2H2-type 19%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102530_255212883704.0Zinc fingerC2H2-type 20
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102711_273412883704.0Zinc fingerC2H2-type 21
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103024_304812883704.0Zinc fingerC2H2-type 22
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103529_355312883704.0Zinc fingerC2H2-type 23
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691040_10643742790.0Zinc fingerC2H2-type 9%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691088_11123742790.0Zinc fingerC2H2-type 10%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691223_12463742790.0Zinc fingerC2H2-type 11%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691252_12753742790.0Zinc fingerC2H2-type 12
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691360_13853742790.0Zinc fingerC2H2-type 13
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691401_14233742790.0Zinc fingerC2H2-type 14
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691429_14523742790.0Zinc fingerC2H2-type 15
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691545_15693742790.0Zinc fingerC2H2-type 16
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691596_16203742790.0Zinc fingerC2H2-type 17
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691983_20063742790.0Zinc fingerC2H2-type 18
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692328_23513742790.0Zinc fingerC2H2-type 19%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692530_25523742790.0Zinc fingerC2H2-type 20
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692711_27343742790.0Zinc fingerC2H2-type 21
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693024_30483742790.0Zinc fingerC2H2-type 22
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693529_35533742790.0Zinc fingerC2H2-type 23
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69640_6633742790.0Zinc fingerC2H2-type 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69671_6943742790.0Zinc fingerC2H2-type 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69726_7503742790.0Zinc fingerC2H2-type 5
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69804_8283742790.0Zinc fingerC2H2-type 6%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69945_9683742790.0Zinc fingerC2H2-type 7%3B degenerate
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69984_10083742790.0Zinc fingerC2H2-type 8%3B atypical
TgeneZMAT4chr16:72845476chr8:40438780ENST0000029773747145_175192230.0Zinc fingerNote=Matrin-type 3
TgeneZMAT4chr16:72845476chr8:40438780ENST000002977374714_44192230.0Zinc fingerNote=Matrin-type 1
TgeneZMAT4chr16:72845476chr8:40438780ENST000002977374772_106192230.0Zinc fingerNote=Matrin-type 2
TgeneZMAT4chr16:72845476chr8:40438780ENST000003157693614_44116154.0Zinc fingerNote=Matrin-type 1
TgeneZMAT4chr16:72845476chr8:40438780ENST000003157693672_106116154.0Zinc fingerNote=Matrin-type 2


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Fusion Gene Sequence for ZFHX3-ZMAT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101001_101001_1_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000268489_ZMAT4_chr8_40438780_ENST00000297737_length(transcript)=6279nt_BP=4537nt
CCGCGCGTCCCTGTGCGTCCCCGGGTCCCTGCGGGCGGGCGGGCGCGGTCGCCGCCGAGCAACCCGGCCTGCGCCCGGCACGACTGTAGA
TGTCAGGCTTTGCCCGGGGAGCCGAGCGGCAGCGGGGCTGTGAGTTTCAAATTAACCTTCCGCTTTGTTGCTGTGTAATGTGGATCCCCG
AAGGCCCCCCGCCCCGCCCGCCCCCCTTCCCCGGGCGGTGCGCGCTGCAAACTGCGAGTTGGGCTTCATTTACATAAAGCGATTCCGGGC
GGGCGGCGGCAGAGGAGGAGGCGGCGGCGGCGGGCAGGCCGGGGACCCGGACGCCAGCGCCGCGCCCCGTGGGTGAATCCCCGCCGCGTC
CCGGGGACCTCCCTCCGGGGACGGGCCGACCGCCAGCCCTGCCGCCACCATGAGCTCCCCTCCCCTGTCTCCGGGCCCCCTGCTCCTGAC
CAGAGCCACCTCCGAGTCCTGGGGCCAGCGGGAGGTGGGGAGCATGCCGCCTGGGGTGGGTGAGCTCGGGGCTCGGGTGCCACTGGAATT
TCCCGTTGTTGCGCATGGCGGCGCGGCCCCCGGACCTGCAAGTGCCGCCTCCCTCCGGAGGTGCGCGGAGGCTTGGTGTGCCAGGTCCGA
GCCTCCGTACTGGGTGCAATGAAAGCTCCACGCAGGCCTTACCATGGAAGGCTGTGACTCGCCCGTCGTCTCGGGGAAGGACAATGGGTG
CGGTATCCCTCAGCACCAGCAATGGACTGAACTCAACAGCACCCACCTCCCTGACAAACCCAGTAGCATGGAGCAGTCCACAGGCGAGAG
CCACGGGCCCTTGGACAGCCTGAGGGCCCCCTTCAATGAGCGCCTCGCGGAGAGCACCGCGTCGGCCGGGCCCCCCTCCGAGCCCGCCAG
CAAGGAGGTCACCTGCAACGAATGTTCGGCCTCCTTTGCCAGCCTCCAGACCTACATGGAGCACCACTGCCCCAGCGCGCGCCCCCCGCC
ACCCCTGAGAGAGGAGAGCGCCAGCGACACCGGTGAGGAGGGGGACGAGGAGAGTGACGTGGAGAACCTGGCCGGGGAGATCGTCTACCA
GCCGGACGGCTCCGCGTACATTGTGGAGAGCCTGAGCCAGCTGACCCAGGGCGGGGGCGCCTGTGGGAGTGGCAGTGGCAGTGGGCCTCT
CCCCTCGCTTTTCCTGAACTCTCTCCCTGGCGCGGGGGGCAAGCAAGGGGACCCTTCGTGTGCTGCACCCGTGTACCCGCAGATCATCAA
CACTTTCCACATAGCCTCATCCTTCGGGAAATGGTTTGAGGGCCCAGACCAGGCTTTCCCGAATACCTCAGCCCTGGCGGGGCTCAGCCC
CGTCCTGCACAGCTTCCGCGTGTTTGACGTGCGACACAAAAGCAACAAGGATTACCTGAACAGCGACGGTTCTGCCAAAAGCTCCTGCGT
ATCCAAAGATGTTCCCAACAATGTGGACCTGTCCAAATTCGATGGCTTTGTGCTCTATGGCAAGAGGAAGCCCATCCTGATGTGTTTCTT
GTGCAAACTCTCCTTTGGGTACGTCCGTTCGTTTGTGACCCACGCGGTGCATGACCATCGAATGACCCTGAGCGAAGACGAGCGGAAAAT
TCTTAGCAATAAGAACATCTCCGCTATCATCCAAGGGATCGGCAAAGACAAGGAACCCCTTGTAAGTTTTCTGGAACCAAAAAACAAAAA
CTTTCAACACCCTTTAGTTTCCACAGCTAACCTCATAGGCCCCGGACACAGTTTTTATGGTAAATTTAGTGGCATTCGAATGGAAGGGGA
GGAAGCTCTCCCAGCGGGCTCCGCCGCTGGCCCCGAGCAGCCCCAGGCTGGTCTCTTGACCCCCAGCACCCTGTTGAACCTTGGCGGGCT
CACCAGCTCGGTACTGAAGACCCCCATTACCTCAGTCCCCCTGGGGCCTCTGGCTTCCAGTCCTACCAAATCCTCAGAGGGCAAGGACTC
TGGGGCGGCAGAAGGAGAGAAGCAGGAAGTGGGCGACGGGGATTGCTTCTCTGAGAAGGTAGAGCCAGCCGAAGAGGAGGCGGAGGAGGA
AGAGGAGGAGGAAGAGGCGGAGGAGGAGGAGGAAGAAGAGGAGGAGGAAGAAGAGGAGGAGGAAGACGAGGGTTGCAAAGGACTCTTTCC
AAGCGAGTTGGATGAGGAACTGGAGGACAGGCCCCATGAGGAGCCTGGGGCCGCAGCAGGTAGTAGCAGCAAAAAGGACCTTGCTCTCTC
AAACCAAAGCATTTCTAACTCCCCCTTAATGCCTAACGTGCTCCAGACCCTGTCGAGGGGCACAGCTTCTACTAGTTCTAATTCTGCTTC
TTCCTTTGTTGTCTTTGATGGTGCGAACAGGAGGAATCGTTTAAGCTTTAACAGTGAGGGCGTCAGGGCCAATGTGGCAGAGGGCGGCAG
GAGGCTGGACTTCGCTGACGAAAGTGCCAATAAAGACAATGCCACAGCACCAGAACCAAATGAAAGCACAGAGGGTGACGATGGGGGCTT
CGTTCCCCATCACCAGCACGCTGGCTCCCTCTGCGAGCTTGGGGTTGGGGAGTGCCCCTCGGGGAGTGGCGTGGAGTGCCCCAAATGCGA
CACGGTCCTGGGCTCCTCCCGCTCGCTGGGCGGCCACATGACCATGATGCATTCTCGTAACTCGTGTAAGACACTCAAGTGCCCCAAGTG
CAACTGGCACTATAAGTACCAGCAGACCCTGGAGGCACACATGAAGGAGAAGCACCCGGAGCCGGGGGGCTCCTGTGTCTACTGCAAAAG
CGGGCAGCCCCACCCCCGGCTGGCACGAGGCGAGAGCTACACGTGTGGTTACAAGCCTTTCCGCTGCGAGGTGTGTAACTACTCCACAAC
TACCAAAGGCAACCTCAGTATTCATATGCAGTCTGACAAGCATCTCAACAACATGCAGAACCTGCAGAATGGAGGGGGGGAGCAGGTCTT
CAGCCACACTGCCGGGGCGGCGGCGGCGGCGGTGGCTGCGGCGGCGGCGGCAGCCAATATCAGTAGCTCCTGCGGGGCCCCCTCGCCGAC
CAAACCAAAAACCAAACCCACCTGGCGGTGCGAGGTGTGTGATTATGAGACCAACGTGGCCAGGAACCTCCGCATTCACATGACCAGTGA
GAAGCACATGCATAACATGATGTTACTGCAACAGAACATGACCCAGATCCAACACAACCGCCACCTGGGCCTCGGCAGCCTGCCCTCACC
CGCCGAGGCCGAGCTCTACCAATACTACCTGGCCCAGAACATGAACCTGCCCAACCTGAAGATGGACAGTGCTGCCTCGGACGCCCAGTT
CATGATGAGCGGATTCCAGCTGGATCCCGCCGGGCCCATGGCCGCCATGACGCCTGCTCTAGTGGGCGGTGAGATCCCCCTAGACATGCG
GCTCGGGGGCGGGCAGCTGGTGTCAGAGGAGCTGATGAACCTGGGCGAGAGCTTCATCCAGACCAACGACCCGTCGCTGAAGCTCTTCCA
GTGCGCCGTCTGCAACAAGTTCACGACGGACAACCTGGACATGCTGGGCCTGCACATGAACGTGGAGCGCAGCCTGTCGGAGGACGAGTG
GAAGGCGGTGATGGGGGACTCATACCAGTGCAAGCTCTGCCGCTACAACACCCAGCTCAAGGCCAACTTCCAGCTGCACTGCAAGACAGA
CAAGCACGTGCAGAAGTACCAGCTGGTGGCCCACATCAAGGAGGGCGGCAAGGCCAACGAGTGGAGGCTCAAGTGTGTGGCCATCGGCAA
CCCCGTGCACCTCAAGTGCAACGCCTGTGACTACTACACCAACAGCCTGGAGAAGCTGCGGCTGCACACGGTCAACTCCAGGCACGAGGC
CAGCCTGAAGTTGTACAAGCACCTGCAGCAGCATGAGAGTGGTGTAGAAGGTGAGAGCTGCTACTACCACTGCGTTCTGTGCAACTACTC
CACCAAGGCCAAGCTCAACCTCATCCAGCATGTGCGCTCCATGAAGCACCAGCGAAGCGAGAGCCTGCGAAAGCTGCAGCGGCTGCAGAA
GGGCCTTCCAGAGGAGGACGAGGACCTGGGGCAGATCTTCACCATCCGCAGGTGCCCCTCCACGGACCCAGAAGAAGCCATTGAAGATGT
TGAAGGACCCAGTGAAACAGCTGCTGATCCAGAGGAGCTTGCTAAGGACCAAGAGGGCGGAGCATCGTCCAGCCAAGCAGAGAAGGAGCT
GACAGATTCTCCTGCAACCTCCAAACGCATCTCCTTCCCAGGTAGCTCAGAGTCTCCCCTCTCTTCGAAGCGACCAAAAACAGCTGAGGA
GATCAAACCGGAGCAGATGTACCAGTGTCCCTACTGCAAGTACAGTAATGCCGATGTCAACCGGCTCCGGGTGCATGCCATGACGCAGCA
CTCGGTGCAACCCATGCTTCGCTGCCCCCTGTGCCAGGACATGCTCAACAACAAGATCCACCTCCAGCTGCACCTCACCCACCTCCACAG
CGTGGCACCTGACTGCGTGGAGAAGCTCATTATGACGGTCTGAGGCGCAATTACAGATGTACCATCTGCAGTGTCTCCCTAAACTCAATA
GAACAGTATCATGCCCATCTGAAAGGATCTAAACACCAGACCAACCTGAAGAATAAGTAGTGAAAGCATCAATCAAGACATAAGAACAAA
ACATTAGCATTTCTCTGCCGTGGAGAATTGCTTATCAACCACCAGAGGAGGCTTCTTTCTTGAACAATAAACATTTCTTATAAGGATTCA
CAGATTCACATACGACTGATCTTGATTTTTGGAAATGAATGAGGTTTCTTTTTTCTTTTTCCTTTTTTTAATTTTGGGGTAAGTTATGAT
ATTTGGATGGATTTTTAAATTCTTTCCTGATAACATATTTAGCACATGTTCTAAATTATAATCCTATAGCAAACAGTTGGAGCATTATTC
AAACTGAAAGTGGAAAAATTTAAATTTCCAATTTATTCTAGATTTCCTCAGAGCATAATTATTCTGTTAAATCCTCAATGAGTGTGATGT
AAACCACCTCTATCCAGAAATATACATTCTTTTCTCATCATGTTGGACACAGTTGAGGGTGACATGCACAGAACTGGAACAGATCACTAT
TAGTGGAAAATACCAAATGGACAAATAAATACCAGTCGTTTTCTCCGTTCTCCAAGCACAGGAGCCAGGTTTACCATCTGAACAATGAAG
ACGAAGGGAGTAAATAAAGGAAGAATTCTCATCTTTTTTCCTGATCATTCAAAGAACAGTTTCTCAAGGTTAAGCCAAGTCCTCCTTGCA
AGTTGCCAAATAATAGCTTAGGAAAAGAATTAGTCTGCCTGCATGATGATCTTCTTAGGCAAAAACGTCTTCACAGCCCTTGACCTTGGT
GAATTTTTTTCCCCAAAAGCATCCAAAAGAAGAATTATAAACCCCAGAATGAGATGGAAATAAACAAGTATTTTTTTTTATGATGTTTGG
CCTGAACTGTGGGCTTTAATTGGGGGATACTGATCGTTTGGAAAGAAGTGAGAAAATTCTGAAGAAATGGCGGCCTTGGGCTAGGCGGGG
TCCCCTATTTCTTCTGTTTCTCACTGAAGTCCTACTGCTGAGCCAAGACTCAGTCACTCTGGAAAGAGCATGACCGATAAAGAAAACAGT
TCCTTTCTGATGGGGAGCGTCTGAGTGCAGATCATGAGGCTCTTTCTCTAGGTTTAATTCTTTTCCATGGTGACCGGACTTGGTGTCTTG
TAGCCTGGTTACGAAGTGGGACGTTGAGCTTCTACTGACGATGCCCTGCATGGACCAGCTGGGATCTGGCTGGGGCTGCCCTGTGTCCCT
AACGACCATAGGCAATCCATCTTCTTGTGTCAGCAATTTCTGGACACCCACTGTTTTCCACCAAGAGCTGAGGTGGCAACAACTCAGTGA
GCAATAAACAAAATGACACAGAAATGCACAGTGTTGTTATGAAGGAGCCTGTTTACCTGTGTTCAAAATCTGGCACCATTCCCTTGAGCA
GGGCCCGCTCAGGAGGGACCAGGTCTGCCAGTTTCTGTGCCTGCAGAGAGACGAAGCCCCACGAGCCACACCCTACTCTACAAGAGGAAA
GGGGGTTGGATGGGAAGAATCTATTTTGCTGTTTTGGAAAGCACACAGCCGACCTACAAACCTCCTGTGATGGTGTTTCTTCGGATGTGT

>101001_101001_1_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000268489_ZMAT4_chr8_40438780_ENST00000297737_length(amino acids)=1289AA_BP=
MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNERLAESTASAGPPSEPASKEVTCNECSASFAS
LQTYMEHHCPSARPPPPLREESASDTGEEGDEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGK
QGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFD
GFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGP
GHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDGD
CFSEKVEPAEEEAEEEEEEEEAEEEEEEEEEEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVL
QTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDDGGFVPHHQHAGSLCELG
VGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYT
CGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAVAAAAAAANISSSCGAPSPTKPKTKPTWRCEVCD
YETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMA
AMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCR
YNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESG
VEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELA
KDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDM

--------------------------------------------------------------
>101001_101001_2_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000268489_ZMAT4_chr8_40438780_ENST00000315769_length(transcript)=6283nt_BP=4537nt
CCGCGCGTCCCTGTGCGTCCCCGGGTCCCTGCGGGCGGGCGGGCGCGGTCGCCGCCGAGCAACCCGGCCTGCGCCCGGCACGACTGTAGA
TGTCAGGCTTTGCCCGGGGAGCCGAGCGGCAGCGGGGCTGTGAGTTTCAAATTAACCTTCCGCTTTGTTGCTGTGTAATGTGGATCCCCG
AAGGCCCCCCGCCCCGCCCGCCCCCCTTCCCCGGGCGGTGCGCGCTGCAAACTGCGAGTTGGGCTTCATTTACATAAAGCGATTCCGGGC
GGGCGGCGGCAGAGGAGGAGGCGGCGGCGGCGGGCAGGCCGGGGACCCGGACGCCAGCGCCGCGCCCCGTGGGTGAATCCCCGCCGCGTC
CCGGGGACCTCCCTCCGGGGACGGGCCGACCGCCAGCCCTGCCGCCACCATGAGCTCCCCTCCCCTGTCTCCGGGCCCCCTGCTCCTGAC
CAGAGCCACCTCCGAGTCCTGGGGCCAGCGGGAGGTGGGGAGCATGCCGCCTGGGGTGGGTGAGCTCGGGGCTCGGGTGCCACTGGAATT
TCCCGTTGTTGCGCATGGCGGCGCGGCCCCCGGACCTGCAAGTGCCGCCTCCCTCCGGAGGTGCGCGGAGGCTTGGTGTGCCAGGTCCGA
GCCTCCGTACTGGGTGCAATGAAAGCTCCACGCAGGCCTTACCATGGAAGGCTGTGACTCGCCCGTCGTCTCGGGGAAGGACAATGGGTG
CGGTATCCCTCAGCACCAGCAATGGACTGAACTCAACAGCACCCACCTCCCTGACAAACCCAGTAGCATGGAGCAGTCCACAGGCGAGAG
CCACGGGCCCTTGGACAGCCTGAGGGCCCCCTTCAATGAGCGCCTCGCGGAGAGCACCGCGTCGGCCGGGCCCCCCTCCGAGCCCGCCAG
CAAGGAGGTCACCTGCAACGAATGTTCGGCCTCCTTTGCCAGCCTCCAGACCTACATGGAGCACCACTGCCCCAGCGCGCGCCCCCCGCC
ACCCCTGAGAGAGGAGAGCGCCAGCGACACCGGTGAGGAGGGGGACGAGGAGAGTGACGTGGAGAACCTGGCCGGGGAGATCGTCTACCA
GCCGGACGGCTCCGCGTACATTGTGGAGAGCCTGAGCCAGCTGACCCAGGGCGGGGGCGCCTGTGGGAGTGGCAGTGGCAGTGGGCCTCT
CCCCTCGCTTTTCCTGAACTCTCTCCCTGGCGCGGGGGGCAAGCAAGGGGACCCTTCGTGTGCTGCACCCGTGTACCCGCAGATCATCAA
CACTTTCCACATAGCCTCATCCTTCGGGAAATGGTTTGAGGGCCCAGACCAGGCTTTCCCGAATACCTCAGCCCTGGCGGGGCTCAGCCC
CGTCCTGCACAGCTTCCGCGTGTTTGACGTGCGACACAAAAGCAACAAGGATTACCTGAACAGCGACGGTTCTGCCAAAAGCTCCTGCGT
ATCCAAAGATGTTCCCAACAATGTGGACCTGTCCAAATTCGATGGCTTTGTGCTCTATGGCAAGAGGAAGCCCATCCTGATGTGTTTCTT
GTGCAAACTCTCCTTTGGGTACGTCCGTTCGTTTGTGACCCACGCGGTGCATGACCATCGAATGACCCTGAGCGAAGACGAGCGGAAAAT
TCTTAGCAATAAGAACATCTCCGCTATCATCCAAGGGATCGGCAAAGACAAGGAACCCCTTGTAAGTTTTCTGGAACCAAAAAACAAAAA
CTTTCAACACCCTTTAGTTTCCACAGCTAACCTCATAGGCCCCGGACACAGTTTTTATGGTAAATTTAGTGGCATTCGAATGGAAGGGGA
GGAAGCTCTCCCAGCGGGCTCCGCCGCTGGCCCCGAGCAGCCCCAGGCTGGTCTCTTGACCCCCAGCACCCTGTTGAACCTTGGCGGGCT
CACCAGCTCGGTACTGAAGACCCCCATTACCTCAGTCCCCCTGGGGCCTCTGGCTTCCAGTCCTACCAAATCCTCAGAGGGCAAGGACTC
TGGGGCGGCAGAAGGAGAGAAGCAGGAAGTGGGCGACGGGGATTGCTTCTCTGAGAAGGTAGAGCCAGCCGAAGAGGAGGCGGAGGAGGA
AGAGGAGGAGGAAGAGGCGGAGGAGGAGGAGGAAGAAGAGGAGGAGGAAGAAGAGGAGGAGGAAGACGAGGGTTGCAAAGGACTCTTTCC
AAGCGAGTTGGATGAGGAACTGGAGGACAGGCCCCATGAGGAGCCTGGGGCCGCAGCAGGTAGTAGCAGCAAAAAGGACCTTGCTCTCTC
AAACCAAAGCATTTCTAACTCCCCCTTAATGCCTAACGTGCTCCAGACCCTGTCGAGGGGCACAGCTTCTACTAGTTCTAATTCTGCTTC
TTCCTTTGTTGTCTTTGATGGTGCGAACAGGAGGAATCGTTTAAGCTTTAACAGTGAGGGCGTCAGGGCCAATGTGGCAGAGGGCGGCAG
GAGGCTGGACTTCGCTGACGAAAGTGCCAATAAAGACAATGCCACAGCACCAGAACCAAATGAAAGCACAGAGGGTGACGATGGGGGCTT
CGTTCCCCATCACCAGCACGCTGGCTCCCTCTGCGAGCTTGGGGTTGGGGAGTGCCCCTCGGGGAGTGGCGTGGAGTGCCCCAAATGCGA
CACGGTCCTGGGCTCCTCCCGCTCGCTGGGCGGCCACATGACCATGATGCATTCTCGTAACTCGTGTAAGACACTCAAGTGCCCCAAGTG
CAACTGGCACTATAAGTACCAGCAGACCCTGGAGGCACACATGAAGGAGAAGCACCCGGAGCCGGGGGGCTCCTGTGTCTACTGCAAAAG
CGGGCAGCCCCACCCCCGGCTGGCACGAGGCGAGAGCTACACGTGTGGTTACAAGCCTTTCCGCTGCGAGGTGTGTAACTACTCCACAAC
TACCAAAGGCAACCTCAGTATTCATATGCAGTCTGACAAGCATCTCAACAACATGCAGAACCTGCAGAATGGAGGGGGGGAGCAGGTCTT
CAGCCACACTGCCGGGGCGGCGGCGGCGGCGGTGGCTGCGGCGGCGGCGGCAGCCAATATCAGTAGCTCCTGCGGGGCCCCCTCGCCGAC
CAAACCAAAAACCAAACCCACCTGGCGGTGCGAGGTGTGTGATTATGAGACCAACGTGGCCAGGAACCTCCGCATTCACATGACCAGTGA
GAAGCACATGCATAACATGATGTTACTGCAACAGAACATGACCCAGATCCAACACAACCGCCACCTGGGCCTCGGCAGCCTGCCCTCACC
CGCCGAGGCCGAGCTCTACCAATACTACCTGGCCCAGAACATGAACCTGCCCAACCTGAAGATGGACAGTGCTGCCTCGGACGCCCAGTT
CATGATGAGCGGATTCCAGCTGGATCCCGCCGGGCCCATGGCCGCCATGACGCCTGCTCTAGTGGGCGGTGAGATCCCCCTAGACATGCG
GCTCGGGGGCGGGCAGCTGGTGTCAGAGGAGCTGATGAACCTGGGCGAGAGCTTCATCCAGACCAACGACCCGTCGCTGAAGCTCTTCCA
GTGCGCCGTCTGCAACAAGTTCACGACGGACAACCTGGACATGCTGGGCCTGCACATGAACGTGGAGCGCAGCCTGTCGGAGGACGAGTG
GAAGGCGGTGATGGGGGACTCATACCAGTGCAAGCTCTGCCGCTACAACACCCAGCTCAAGGCCAACTTCCAGCTGCACTGCAAGACAGA
CAAGCACGTGCAGAAGTACCAGCTGGTGGCCCACATCAAGGAGGGCGGCAAGGCCAACGAGTGGAGGCTCAAGTGTGTGGCCATCGGCAA
CCCCGTGCACCTCAAGTGCAACGCCTGTGACTACTACACCAACAGCCTGGAGAAGCTGCGGCTGCACACGGTCAACTCCAGGCACGAGGC
CAGCCTGAAGTTGTACAAGCACCTGCAGCAGCATGAGAGTGGTGTAGAAGGTGAGAGCTGCTACTACCACTGCGTTCTGTGCAACTACTC
CACCAAGGCCAAGCTCAACCTCATCCAGCATGTGCGCTCCATGAAGCACCAGCGAAGCGAGAGCCTGCGAAAGCTGCAGCGGCTGCAGAA
GGGCCTTCCAGAGGAGGACGAGGACCTGGGGCAGATCTTCACCATCCGCAGGTGCCCCTCCACGGACCCAGAAGAAGCCATTGAAGATGT
TGAAGGACCCAGTGAAACAGCTGCTGATCCAGAGGAGCTTGCTAAGGACCAAGAGGGCGGAGCATCGTCCAGCCAAGCAGAGAAGGAGCT
GACAGATTCTCCTGCAACCTCCAAACGCATCTCCTTCCCAGGTAGCTCAGAGTCTCCCCTCTCTTCGAAGCGACCAAAAACAGCTGAGGA
GATCAAACCGGAGCAGATGTACCAGTGTCCCTACTGCAAGTACAGTAATGCCGATGTCAACCGGCTCCGGGTGCATGCCATGACGCAGCA
CTCGGTGCAACCCATGCTTCGCTGCCCCCTGTGCCAGGACATGCTCAACAACAAGATCCACCTCCAGCTGCACCTCACCCACCTCCACAG
CGTGGCACCTGACTGCGTGGAGAAGCTCATTATGACGGTCTGAGGCGCAATTACAGATGTACCATCTGCAGTGTCTCCCTAAACTCAATA
GAACAGTATCATGCCCATCTGAAAGGATCTAAACACCAGACCAACCTGAAGAATAAGTAGTGAAAGCATCAATCAAGACATAAGAACAAA
ACATTAGCATTTCTCTGCCGTGGAGAATTGCTTATCAACCACCAGAGGAGGCTTCTTTCTTGAACAATAAACATTTCTTATAAGGATTCA
CAGATTCACATACGACTGATCTTGATTTTTGGAAATGAATGAGGTTTCTTTTTTCTTTTTCCTTTTTTTAATTTTGGGGTAAGTTATGAT
ATTTGGATGGATTTTTAAATTCTTTCCTGATAACATATTTAGCACATGTTCTAAATTATAATCCTATAGCAAACAGTTGGAGCATTATTC
AAACTGAAAGTGGAAAAATTTAAATTTCCAATTTATTCTAGATTTCCTCAGAGCATAATTATTCTGTTAAATCCTCAATGAGTGTGATGT
AAACCACCTCTATCCAGAAATATACATTCTTTTCTCATCATGTTGGACACAGTTGAGGGTGACATGCACAGAACTGGAACAGATCACTAT
TAGTGGAAAATACCAAATGGACAAATAAATACCAGTCGTTTTCTCCGTTCTCCAAGCACAGGAGCCAGGTTTACCATCTGAACAATGAAG
ACGAAGGGAGTAAATAAAGGAAGAATTCTCATCTTTTTTCCTGATCATTCAAAGAACAGTTTCTCAAGGTTAAGCCAAGTCCTCCTTGCA
AGTTGCCAAATAATAGCTTAGGAAAAGAATTAGTCTGCCTGCATGATGATCTTCTTAGGCAAAAACGTCTTCACAGCCCTTGACCTTGGT
GAATTTTTTTCCCCAAAAGCATCCAAAAGAAGAATTATAAACCCCAGAATGAGATGGAAATAAACAAGTATTTTTTTTTATGATGTTTGG
CCTGAACTGTGGGCTTTAATTGGGGGATACTGATCGTTTGGAAAGAAGTGAGAAAATTCTGAAGAAATGGCGGCCTTGGGCTAGGCGGGG
TCCCCTATTTCTTCTGTTTCTCACTGAAGTCCTACTGCTGAGCCAAGACTCAGTCACTCTGGAAAGAGCATGACCGATAAAGAAAACAGT
TCCTTTCTGATGGGGAGCGTCTGAGTGCAGATCATGAGGCTCTTTCTCTAGGTTTAATTCTTTTCCATGGTGACCGGACTTGGTGTCTTG
TAGCCTGGTTACGAAGTGGGACGTTGAGCTTCTACTGACGATGCCCTGCATGGACCAGCTGGGATCTGGCTGGGGCTGCCCTGTGTCCCT
AACGACCATAGGCAATCCATCTTCTTGTGTCAGCAATTTCTGGACACCCACTGTTTTCCACCAAGAGCTGAGGTGGCAACAACTCAGTGA
GCAATAAACAAAATGACACAGAAATGCACAGTGTTGTTATGAAGGAGCCTGTTTACCTGTGTTCAAAATCTGGCACCATTCCCTTGAGCA
GGGCCCGCTCAGGAGGGACCAGGTCTGCCAGTTTCTGTGCCTGCAGAGAGACGAAGCCCCACGAGCCACACCCTACTCTACAAGAGGAAA
GGGGGTTGGATGGGAAGAATCTATTTTGCTGTTTTGGAAAGCACACAGCCGACCTACAAACCTCCTGTGATGGTGTTTCTTCGGATGTGT

>101001_101001_2_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000268489_ZMAT4_chr8_40438780_ENST00000315769_length(amino acids)=1289AA_BP=
MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNERLAESTASAGPPSEPASKEVTCNECSASFAS
LQTYMEHHCPSARPPPPLREESASDTGEEGDEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGK
QGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFD
GFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGP
GHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDGD
CFSEKVEPAEEEAEEEEEEEEAEEEEEEEEEEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVL
QTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDDGGFVPHHQHAGSLCELG
VGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYT
CGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAVAAAAAAANISSSCGAPSPTKPKTKPTWRCEVCD
YETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMA
AMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCR
YNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESG
VEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELA
KDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDM

--------------------------------------------------------------
>101001_101001_3_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000397992_ZMAT4_chr8_40438780_ENST00000297737_length(transcript)=4056nt_BP=2314nt
AATTTAAAGTGGTCTCTATTCGAAGTCTCTGCTCTTTCACTTAAACCTTTACTCTAAGCTGTCCCCCTCCACTAATGCCCCCATTCTTTG
GAGATGCTCTTTTCCTAGTTAATTTAAACATTGCTGCGTTTGCTTAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAAGGGG
AAAATAATAAGAAAGAAAAGAGAAGGGGGGGAAGAAGAAAGGAAAAAAAAAATCTTAAAAAGATTCTTAGCCAGGTTCCTATTGTTGCTC
CTATGCATTCCACTTCTCGGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGCTCGTGTGTGTGTCGTGTGTGTGTGTGT
GTGTGTTTTTAATACATGCATAAACTTTTGGAGCCTCTCTCCCTCTTCTAGGCTCTTCTCCCATCCTCTCTTCCTGCTCTCCTTGCCCTG
CTCATCACTTTCCCCTGTTTTTTTTTTTTTTTCCTCCCTTCCTCCCCTCTGCCTCCCTCCACCTCCCCCTTTTCTTTTTTGCTGAATCTT
ATTGATCCAGAAGGTGGCTAATTAGCCCTTCCCGTCGTGCCTGGGTAATGAAGCACATGCGCACTGAATTAATCACAGCCATTTTTTGCA
GGAAACTAATTAGCAGAATAAAGATCCAAAGACTTTTTTTTCTTTTCACTCATCAGCTCCCACTTCCAGCGCGTCCCCTCCGACCGCTGC
AGCCGCCACCGCCGCCGCCTCCTCCTCCTCCTCCTCCCGGCCGCAGCCGCCGCCGCCGCCTGCTTTGCATCCCAATTACAGCCTAGAGCC
GCTGCCGCCGCCGCCGCCGCTTCTCTTCCGTGGCCCCTGCCCGCTCCGGGGGCTGTAAACTCCCCGCCAACCATGCTGCTCGGCGGCAGC
GGCGGCGGCGGCTCCGGCTCCCCGGCTGCGGCCGCCTCCCGCCCCGGGCTCCGCCGAGCGCGCTCCAGCTCCGCCGCCGCCGCCGCCGCC
GCCGCCGCCGCCAGCAGCGCGTCCTCCGCCGCCGCCGACCCCCGCCAGCCGCCGCTGCTGCCTTGATGGGCTCCGCGGCCCGAGCGCCTC
TTTTCGGGATTAAAAGCGCCGCCAGCTCCCGCCGCCGCCGCCGTCGCCAGCAGCGCCGCTGCAGCCGCCGCCGCCGGAGAAGCAACCGCT
GGGCGGTGAGATCCCCCTAGACATGCGGCTCGGGGGCGGGCAGCTGGTGTCAGAGGAGCTGATGAACCTGGGCGAGAGCTTCATCCAGAC
CAACGACCCGTCGCTGAAGCTCTTCCAGTGCGCCGTCTGCAACAAGTTCACGACGGACAACCTGGACATGCTGGGCCTGCACATGAACGT
GGAGCGCAGCCTGTCGGAGGACGAGTGGAAGGCGGTGATGGGGGACTCATACCAGTGCAAGCTCTGCCGCTACAACACCCAGCTCAAGGC
CAACTTCCAGCTGCACTGCAAGACAGACAAGCACGTGCAGAAGTACCAGCTGGTGGCCCACATCAAGGAGGGCGGCAAGGCCAACGAGTG
GAGGCTCAAGTGTGTGGCCATCGGCAACCCCGTGCACCTCAAGTGCAACGCCTGTGACTACTACACCAACAGCCTGGAGAAGCTGCGGCT
GCACACGGTCAACTCCAGGCACGAGGCCAGCCTGAAGTTGTACAAGCACCTGCAGCAGCATGAGAGTGGTGTAGAAGGTGAGAGCTGCTA
CTACCACTGCGTTCTGTGCAACTACTCCACCAAGGCCAAGCTCAACCTCATCCAGCATGTGCGCTCCATGAAGCACCAGCGAAGCGAGAG
CCTGCGAAAGCTGCAGCGGCTGCAGAAGGGCCTTCCAGAGGAGGACGAGGACCTGGGGCAGATCTTCACCATCCGCAGGTGCCCCTCCAC
GGACCCAGAAGAAGCCATTGAAGATGTTGAAGGACCCAGTGAAACAGCTGCTGATCCAGAGGAGCTTGCTAAGGACCAAGAGGGCGGAGC
ATCGTCCAGCCAAGCAGAGAAGGAGCTGACAGATTCTCCTGCAACCTCCAAACGCATCTCCTTCCCAGGTAGCTCAGAGTCTCCCCTCTC
TTCGAAGCGACCAAAAACAGCTGAGGAGATCAAACCGGAGCAGATGTACCAGTGTCCCTACTGCAAGTACAGTAATGCCGATGTCAACCG
GCTCCGGGTGCATGCCATGACGCAGCACTCGGTGCAACCCATGCTTCGCTGCCCCCTGTGCCAGGACATGCTCAACAACAAGATCCACCT
CCAGCTGCACCTCACCCACCTCCACAGCGTGGCACCTGACTGCGTGGAGAAGCTCATTATGACGGTCTGAGGCGCAATTACAGATGTACC
ATCTGCAGTGTCTCCCTAAACTCAATAGAACAGTATCATGCCCATCTGAAAGGATCTAAACACCAGACCAACCTGAAGAATAAGTAGTGA
AAGCATCAATCAAGACATAAGAACAAAACATTAGCATTTCTCTGCCGTGGAGAATTGCTTATCAACCACCAGAGGAGGCTTCTTTCTTGA
ACAATAAACATTTCTTATAAGGATTCACAGATTCACATACGACTGATCTTGATTTTTGGAAATGAATGAGGTTTCTTTTTTCTTTTTCCT
TTTTTTAATTTTGGGGTAAGTTATGATATTTGGATGGATTTTTAAATTCTTTCCTGATAACATATTTAGCACATGTTCTAAATTATAATC
CTATAGCAAACAGTTGGAGCATTATTCAAACTGAAAGTGGAAAAATTTAAATTTCCAATTTATTCTAGATTTCCTCAGAGCATAATTATT
CTGTTAAATCCTCAATGAGTGTGATGTAAACCACCTCTATCCAGAAATATACATTCTTTTCTCATCATGTTGGACACAGTTGAGGGTGAC
ATGCACAGAACTGGAACAGATCACTATTAGTGGAAAATACCAAATGGACAAATAAATACCAGTCGTTTTCTCCGTTCTCCAAGCACAGGA
GCCAGGTTTACCATCTGAACAATGAAGACGAAGGGAGTAAATAAAGGAAGAATTCTCATCTTTTTTCCTGATCATTCAAAGAACAGTTTC
TCAAGGTTAAGCCAAGTCCTCCTTGCAAGTTGCCAAATAATAGCTTAGGAAAAGAATTAGTCTGCCTGCATGATGATCTTCTTAGGCAAA
AACGTCTTCACAGCCCTTGACCTTGGTGAATTTTTTTCCCCAAAAGCATCCAAAAGAAGAATTATAAACCCCAGAATGAGATGGAAATAA
ACAAGTATTTTTTTTTATGATGTTTGGCCTGAACTGTGGGCTTTAATTGGGGGATACTGATCGTTTGGAAAGAAGTGAGAAAATTCTGAA
GAAATGGCGGCCTTGGGCTAGGCGGGGTCCCCTATTTCTTCTGTTTCTCACTGAAGTCCTACTGCTGAGCCAAGACTCAGTCACTCTGGA
AAGAGCATGACCGATAAAGAAAACAGTTCCTTTCTGATGGGGAGCGTCTGAGTGCAGATCATGAGGCTCTTTCTCTAGGTTTAATTCTTT
TCCATGGTGACCGGACTTGGTGTCTTGTAGCCTGGTTACGAAGTGGGACGTTGAGCTTCTACTGACGATGCCCTGCATGGACCAGCTGGG
ATCTGGCTGGGGCTGCCCTGTGTCCCTAACGACCATAGGCAATCCATCTTCTTGTGTCAGCAATTTCTGGACACCCACTGTTTTCCACCA
AGAGCTGAGGTGGCAACAACTCAGTGAGCAATAAACAAAATGACACAGAAATGCACAGTGTTGTTATGAAGGAGCCTGTTTACCTGTGTT
CAAAATCTGGCACCATTCCCTTGAGCAGGGCCCGCTCAGGAGGGACCAGGTCTGCCAGTTTCTGTGCCTGCAGAGAGACGAAGCCCCACG
AGCCACACCCTACTCTACAAGAGGAAAGGGGGTTGGATGGGAAGAATCTATTTTGCTGTTTTGGAAAGCACACAGCCGACCTACAAACCT
CCTGTGATGGTGTTTCTTCGGATGTGTAAAATAAGGCTTTATTTGTCAATTCCGCTGTAAAATAAGCATTGTCCGAGTAAAAACAGCAGC

>101001_101001_3_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000397992_ZMAT4_chr8_40438780_ENST00000297737_length(amino acids)=393AA_BP=
MQPPPPEKQPLGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQC
KLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQ
HESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADP
EELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPL

--------------------------------------------------------------
>101001_101001_4_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000397992_ZMAT4_chr8_40438780_ENST00000315769_length(transcript)=4060nt_BP=2314nt
AATTTAAAGTGGTCTCTATTCGAAGTCTCTGCTCTTTCACTTAAACCTTTACTCTAAGCTGTCCCCCTCCACTAATGCCCCCATTCTTTG
GAGATGCTCTTTTCCTAGTTAATTTAAACATTGCTGCGTTTGCTTAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAAGGGG
AAAATAATAAGAAAGAAAAGAGAAGGGGGGGAAGAAGAAAGGAAAAAAAAAATCTTAAAAAGATTCTTAGCCAGGTTCCTATTGTTGCTC
CTATGCATTCCACTTCTCGGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGCTCGTGTGTGTGTCGTGTGTGTGTGTGT
GTGTGTTTTTAATACATGCATAAACTTTTGGAGCCTCTCTCCCTCTTCTAGGCTCTTCTCCCATCCTCTCTTCCTGCTCTCCTTGCCCTG
CTCATCACTTTCCCCTGTTTTTTTTTTTTTTTCCTCCCTTCCTCCCCTCTGCCTCCCTCCACCTCCCCCTTTTCTTTTTTGCTGAATCTT
ATTGATCCAGAAGGTGGCTAATTAGCCCTTCCCGTCGTGCCTGGGTAATGAAGCACATGCGCACTGAATTAATCACAGCCATTTTTTGCA
GGAAACTAATTAGCAGAATAAAGATCCAAAGACTTTTTTTTCTTTTCACTCATCAGCTCCCACTTCCAGCGCGTCCCCTCCGACCGCTGC
AGCCGCCACCGCCGCCGCCTCCTCCTCCTCCTCCTCCCGGCCGCAGCCGCCGCCGCCGCCTGCTTTGCATCCCAATTACAGCCTAGAGCC
GCTGCCGCCGCCGCCGCCGCTTCTCTTCCGTGGCCCCTGCCCGCTCCGGGGGCTGTAAACTCCCCGCCAACCATGCTGCTCGGCGGCAGC
GGCGGCGGCGGCTCCGGCTCCCCGGCTGCGGCCGCCTCCCGCCCCGGGCTCCGCCGAGCGCGCTCCAGCTCCGCCGCCGCCGCCGCCGCC
GCCGCCGCCGCCAGCAGCGCGTCCTCCGCCGCCGCCGACCCCCGCCAGCCGCCGCTGCTGCCTTGATGGGCTCCGCGGCCCGAGCGCCTC
TTTTCGGGATTAAAAGCGCCGCCAGCTCCCGCCGCCGCCGCCGTCGCCAGCAGCGCCGCTGCAGCCGCCGCCGCCGGAGAAGCAACCGCT
GGGCGGTGAGATCCCCCTAGACATGCGGCTCGGGGGCGGGCAGCTGGTGTCAGAGGAGCTGATGAACCTGGGCGAGAGCTTCATCCAGAC
CAACGACCCGTCGCTGAAGCTCTTCCAGTGCGCCGTCTGCAACAAGTTCACGACGGACAACCTGGACATGCTGGGCCTGCACATGAACGT
GGAGCGCAGCCTGTCGGAGGACGAGTGGAAGGCGGTGATGGGGGACTCATACCAGTGCAAGCTCTGCCGCTACAACACCCAGCTCAAGGC
CAACTTCCAGCTGCACTGCAAGACAGACAAGCACGTGCAGAAGTACCAGCTGGTGGCCCACATCAAGGAGGGCGGCAAGGCCAACGAGTG
GAGGCTCAAGTGTGTGGCCATCGGCAACCCCGTGCACCTCAAGTGCAACGCCTGTGACTACTACACCAACAGCCTGGAGAAGCTGCGGCT
GCACACGGTCAACTCCAGGCACGAGGCCAGCCTGAAGTTGTACAAGCACCTGCAGCAGCATGAGAGTGGTGTAGAAGGTGAGAGCTGCTA
CTACCACTGCGTTCTGTGCAACTACTCCACCAAGGCCAAGCTCAACCTCATCCAGCATGTGCGCTCCATGAAGCACCAGCGAAGCGAGAG
CCTGCGAAAGCTGCAGCGGCTGCAGAAGGGCCTTCCAGAGGAGGACGAGGACCTGGGGCAGATCTTCACCATCCGCAGGTGCCCCTCCAC
GGACCCAGAAGAAGCCATTGAAGATGTTGAAGGACCCAGTGAAACAGCTGCTGATCCAGAGGAGCTTGCTAAGGACCAAGAGGGCGGAGC
ATCGTCCAGCCAAGCAGAGAAGGAGCTGACAGATTCTCCTGCAACCTCCAAACGCATCTCCTTCCCAGGTAGCTCAGAGTCTCCCCTCTC
TTCGAAGCGACCAAAAACAGCTGAGGAGATCAAACCGGAGCAGATGTACCAGTGTCCCTACTGCAAGTACAGTAATGCCGATGTCAACCG
GCTCCGGGTGCATGCCATGACGCAGCACTCGGTGCAACCCATGCTTCGCTGCCCCCTGTGCCAGGACATGCTCAACAACAAGATCCACCT
CCAGCTGCACCTCACCCACCTCCACAGCGTGGCACCTGACTGCGTGGAGAAGCTCATTATGACGGTCTGAGGCGCAATTACAGATGTACC
ATCTGCAGTGTCTCCCTAAACTCAATAGAACAGTATCATGCCCATCTGAAAGGATCTAAACACCAGACCAACCTGAAGAATAAGTAGTGA
AAGCATCAATCAAGACATAAGAACAAAACATTAGCATTTCTCTGCCGTGGAGAATTGCTTATCAACCACCAGAGGAGGCTTCTTTCTTGA
ACAATAAACATTTCTTATAAGGATTCACAGATTCACATACGACTGATCTTGATTTTTGGAAATGAATGAGGTTTCTTTTTTCTTTTTCCT
TTTTTTAATTTTGGGGTAAGTTATGATATTTGGATGGATTTTTAAATTCTTTCCTGATAACATATTTAGCACATGTTCTAAATTATAATC
CTATAGCAAACAGTTGGAGCATTATTCAAACTGAAAGTGGAAAAATTTAAATTTCCAATTTATTCTAGATTTCCTCAGAGCATAATTATT
CTGTTAAATCCTCAATGAGTGTGATGTAAACCACCTCTATCCAGAAATATACATTCTTTTCTCATCATGTTGGACACAGTTGAGGGTGAC
ATGCACAGAACTGGAACAGATCACTATTAGTGGAAAATACCAAATGGACAAATAAATACCAGTCGTTTTCTCCGTTCTCCAAGCACAGGA
GCCAGGTTTACCATCTGAACAATGAAGACGAAGGGAGTAAATAAAGGAAGAATTCTCATCTTTTTTCCTGATCATTCAAAGAACAGTTTC
TCAAGGTTAAGCCAAGTCCTCCTTGCAAGTTGCCAAATAATAGCTTAGGAAAAGAATTAGTCTGCCTGCATGATGATCTTCTTAGGCAAA
AACGTCTTCACAGCCCTTGACCTTGGTGAATTTTTTTCCCCAAAAGCATCCAAAAGAAGAATTATAAACCCCAGAATGAGATGGAAATAA
ACAAGTATTTTTTTTTATGATGTTTGGCCTGAACTGTGGGCTTTAATTGGGGGATACTGATCGTTTGGAAAGAAGTGAGAAAATTCTGAA
GAAATGGCGGCCTTGGGCTAGGCGGGGTCCCCTATTTCTTCTGTTTCTCACTGAAGTCCTACTGCTGAGCCAAGACTCAGTCACTCTGGA
AAGAGCATGACCGATAAAGAAAACAGTTCCTTTCTGATGGGGAGCGTCTGAGTGCAGATCATGAGGCTCTTTCTCTAGGTTTAATTCTTT
TCCATGGTGACCGGACTTGGTGTCTTGTAGCCTGGTTACGAAGTGGGACGTTGAGCTTCTACTGACGATGCCCTGCATGGACCAGCTGGG
ATCTGGCTGGGGCTGCCCTGTGTCCCTAACGACCATAGGCAATCCATCTTCTTGTGTCAGCAATTTCTGGACACCCACTGTTTTCCACCA
AGAGCTGAGGTGGCAACAACTCAGTGAGCAATAAACAAAATGACACAGAAATGCACAGTGTTGTTATGAAGGAGCCTGTTTACCTGTGTT
CAAAATCTGGCACCATTCCCTTGAGCAGGGCCCGCTCAGGAGGGACCAGGTCTGCCAGTTTCTGTGCCTGCAGAGAGACGAAGCCCCACG
AGCCACACCCTACTCTACAAGAGGAAAGGGGGTTGGATGGGAAGAATCTATTTTGCTGTTTTGGAAAGCACACAGCCGACCTACAAACCT
CCTGTGATGGTGTTTCTTCGGATGTGTAAAATAAGGCTTTATTTGTCAATTCCGCTGTAAAATAAGCATTGTCCGAGTAAAAACAGCAGC

>101001_101001_4_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000397992_ZMAT4_chr8_40438780_ENST00000315769_length(amino acids)=393AA_BP=
MQPPPPEKQPLGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQC
KLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQ
HESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADP
EELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZFHX3-ZMAT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFHX3-ZMAT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZFHX3-ZMAT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource