Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZFPM1-KLF6 (FusionGDB2 ID:101106)

Fusion Gene Summary for ZFPM1-KLF6

Fusion gene summary

Fusion gene information	Fusion gene name: ZFPM1-KLF6
	Fusion gene ID: 101106
		Hgene	Tgene
	Gene symbol	ZFPM1	KLF6
	Gene ID	161882	1316
	Gene name	zinc finger protein, FOG family member 1	Kruppel like factor 6
	Synonyms	FOG\|FOG1\|ZC2HC11A\|ZNF408\|ZNF89A	BCD1\|CBA1\|COPEB\|CPBP\|GBF\|PAC1\|ST12\|ZF9
	Cytomap	16q24.2	10p15.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein ZFPM1FOG-1friend of GATA 1friend of GATA protein 1zinc finger protein 89Azinc finger protein, multitype 1	Krueppel-like factor 6B-cell-derived protein 1GC-rich binding factorGC-rich sites-binding factor GBFKruppel-like zinc finger protein Zf9core promoter element-binding proteinproto-oncogene BCD1protooncogene B-cell derived 1suppression of tumorigeni
	Modification date	20200313	20200313
	UniProtAcc	.	Q99612
	Ensembl transtripts involved in fusion gene	ENST00000569086, ENST00000319555,	ENST00000497571, ENST00000542957, ENST00000173785, ENST00000469435,
Fusion gene scores	* DoF score	1 X 1 X 1=1	10 X 10 X 2=200
	# samples	1	10
	** MAII score	log2(1/1*10)=3.32192809488736	log2(10/200*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZFPM1 [Title/Abstract] AND KLF6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZFPM1(88580928)-KLF6(3824407), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ZFPM1	GO:0010724	regulation of definitive erythrocyte differentiation	15920471
Hgene	ZFPM1	GO:0045078	positive regulation of interferon-gamma biosynthetic process	21646796
Hgene	ZFPM1	GO:0045403	negative regulation of interleukin-4 biosynthetic process	21646796
Tgene	KLF6	GO:0045944	positive regulation of transcription by RNA polymerase II	18755691

Fusion gene breakpoints across ZFPM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KLF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CT004488	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-

Top

Fusion Gene ORF analysis for ZFPM1-KLF6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000569086	ENST00000497571	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-
3UTR-3CDS	ENST00000569086	ENST00000542957	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-
3UTR-intron	ENST00000569086	ENST00000173785	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-
3UTR-intron	ENST00000569086	ENST00000469435	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-
5CDS-intron	ENST00000319555	ENST00000173785	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-
5CDS-intron	ENST00000319555	ENST00000469435	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-
In-frame	ENST00000319555	ENST00000497571	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-
In-frame	ENST00000319555	ENST00000542957	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000319555

ZFPM1

chr16

88580928

ENST00000497571

KLF6

chr10

3824407

5017

724

1473

482

ENST00000319555

ZFPM1

chr16

88580928

ENST00000542957

KLF6

chr10

3824407

4892

724

1335

436

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000319555	ENST00000497571	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-	0.02314472	0.9768553
ENST00000319555	ENST00000542957	ZFPM1	chr16	88580928	+	KLF6	chr10	3824407	-	0.009790309	0.9902097

Top

Fusion Genomic Features for ZFPM1-KLF6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZFPM1-KLF6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:88580928/chr10:3824407)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KLF6 Q99612
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000469435

62_70

282.0

Motif

9aaTAD%3B inactive

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000497571

62_70

284.0

Motif

9aaTAD%3B inactive

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000542957

62_70

238.0

Motif

9aaTAD%3B inactive

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000469435

200_224

282.0

Zinc finger

C2H2-type 1

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000469435

230_254

282.0

Zinc finger

C2H2-type 2

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000469435

260_282

282.0

Zinc finger

C2H2-type 3

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000497571

200_224

284.0

Zinc finger

C2H2-type 1

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000497571

230_254

284.0

Zinc finger

C2H2-type 2

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000497571

260_282

284.0

Zinc finger

C2H2-type 3

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000542957

200_224

238.0

Zinc finger

C2H2-type 1

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000542957

230_254

238.0

Zinc finger

C2H2-type 2

Tgene

KLF6

chr16:88580928

chr10:3824407

ENST00000542957

260_282

238.0

Zinc finger

C2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

235_268

134

1007.0

Zinc finger

CCHC FOG-type 1

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

290_314

134

1007.0

Zinc finger

C2H2-type 1

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

320_342

134

1007.0

Zinc finger

C2H2-type 2

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

348_371

134

1007.0

Zinc finger

C2H2-type 3

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

571_604

134

1007.0

Zinc finger

CCHC FOG-type 2

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

677_710

134

1007.0

Zinc finger

CCHC FOG-type 3

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

811_844

134

1007.0

Zinc finger

CCHC FOG-type 4

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

854_877

134

1007.0

Zinc finger

C2H2-type 4

Hgene

ZFPM1

chr16:88580928

chr10:3824407

ENST00000319555

968_1001

134

1007.0

Zinc finger

CCHC FOG-type 5

Top

Fusion Gene Sequence for ZFPM1-KLF6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>101106_101106_1_ZFPM1-KLF6_ZFPM1_chr16_88580928_ENST00000319555_KLF6_chr10_3824407_ENST00000497571_length(transcript)=5017nt_BP=724nt
CGCCGCTCGCCGCCCGCGGGTTCCATTGAGAAAAGCCGAGCGGCCGCGGCGGCGGCGGCGAGTGCGCGGGAGCGGAGGAGCCGGCACCCG
CCCGTCGGGCAGTCCGCGCGCCCGCAACGCAGGACCGTGGCCTCTCGGGCCTCCGCGGCAGCTCCAGCGGCTCCGGGGCTGGGCGCGCGG
GCTGGGGGCGCGGGCCGGGGCGGCCGCGGAGACCGGGGGCCGGGGGCATGAGCGGCCCCGCGGCCCCGCCGCGCCCCCGCCGCCCGCCGC
CGCCCGCCCGGGGCTAGAGGCGGCCGCCGGGAGGGCGCGCGGCGCCGGAGACATGTCCAGGCGGAAACAGAGCAACCCCCGGCAGATCAA
GCGTTCCCTCGGAGACATGGAGGCCAGAGAGGAGGTGCAGTTGGTGGGTGCCAGCCACATGGAGCAAAAGGCCACGGCACCTGAAGCCCC
GAGCCCTCCCAGCGCAGATGTTAACTCACCCCCACCGCTGCCGCCCCCCACATCCCCAGGAGGCCCCAAGGAGCTGGAAGGACAGGAACC
AGAACCCAGGCCCACGGAGGAAGAGCCGGGCAGTCCCTGGAGCGGGCCAGACGAGCTGGAGCCGGTGGTGCAGGATGGGCAGAGGCGCAT
ACGGGCCCGACTCAGCCTCGCCACGGGCCTGTCCTGGGGCCCGTTCCATGGGAGTGTCCAGACCAGAGCCTCATCCCCCAGGCAGGCGGA
GCCGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCT
GTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCC
GAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGC
CAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGA
ACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCC
AGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAA
AAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAG
AAGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGTGTTTTTCCAGGTCTGA
CCACCTGGCCCTGCACATGAAGAGGCACCTCTGAGGGAGCAGAGAGGTGGATCCTGTAGGCTAAAAGGCTTCCAGGCTGAGAGCCGGCCG
TGGAAGGAGGGATGCGTGTTCCAGCCAAAGCATGCCGTTCTGCACCCTACCCAGTTGCCTCCAGGGCCTCTCCTTGGAAGGTCTTTTGAG
GGCTAAAAAGGTCCTGTAAGAAGCGGCATAGCACCCGTGGTGCATGGTATGTGGGTGACCCTGGACTCGCCACTGGTACCCGCCCTTCCG
AGCGGCGCCTAAGCCTTTGCCGTGAGCATGCACACTGAGAATGCTAATGGTTGGGTTGATTGTATGTTGAGGATCTATTACTGACCGTAT
GATGAGGCCAACTTTTTTTCCTTGTGGTTAGCAAGACTGCAAGAGATGGAAAAAAAGTAGTTTGAATGTTTTGTGTGTAAGGAGTATACC
ATGAGATGAGATGACCACCAATCATTTCCTTGGGGGGAGGGGGTGTCTGCACCTTAGAAAAAAAAAGAAAAATCAAAAAAACAAAAAAAC
AAAAACAAAAAAAGAAGGAAAATCTTGGAGGGTGGGCGTGGGAACTCAGGACCCCAGAGTGGCGAGTGGTGTGGGGAGGGAGAGCCTCTC
TCCCCCTTTTCTGTGTGAGAGGAACTCTTAGTGTCTGGTGCAGCTATTAAATGTGCAATGTGTCAAGTAGCTTGTTTTACACGCTACAAC
ATAGCTCATTTGTAACCCATTGTATAAGCTGTGTATTTACAAATATAACACAACAATTTAACTTTTCCTTAGAATACAAAAAGTCATGCA
TGGTCTGGGGAACTATATGCTTTTCCATTTTTAAGTCAGGACTGCAATACTGATTCCAGTTAATGAGCAGCTAAGATCCAATCTGTCTAA
TACAGTGACCCCCTAGCCATCCGGGCCTGGCAATATACAATTTTTTTTCCCCTCCAAGTTTGTAACACTCCCCTTCCAGAAAGGCATTGT
GCAACACAGGATTATTTTTAAATGATTCTGAATTTGAATTAACTTTTTGGAGAATTCTGTGATGCCCTTAGAAGAAATTGGACACGTATT
GAGTGTCACAAAGCTGGGGCTGGGAATTGCTGGTCTAATGTTTCATTAGACTTAAGAACCTAAAATTTTTCTCAGTTGGGTGGATAAAAC
CACTAACGCTTAGAAACTGTTTTCTCATGCAGCTATGTTTCTCTTATTTATGCCTTGAGGACTAATTTCTGGTTTTCTAGCTGTTAATGC
ACTGTTGACCTTCATAATGGTGCCTTACGCAAGCGATCCCTTCTGTGGGGGTCTCATACAGGGGTGTGGGCGATGCATGCTTTATTAAGG
CTCTTGTTTCACCTGGCAGTGTACTGTATCAACGTATAATACAGAAAAAAAATCTCTTTAAGGTCCTCCTTCACAAAGACATAGAGTGAA
ACTCCCTTTACATGTCAGTATTTGTTCAACACTTTAGGCAACTTGACTGTCAGTGTTAAAATGGAAAACAGGAAAATGGAAAAATCTGAC
CAATTCTGCCACCTTGAGACTTTCATATAGACCTTGCACAACAATTGTATAGATCACACACCGGCTGTATTTAATATGTAACATTTTCAC
ACATATTAAAGATACAGAAGTATTAAAAAACCCCCAATGTTAATGTATTTGCTTAAAAGGCACAAGTTTCACATATCTGTCTAGCTATCT
GTTGGTAATACAGAAAGTATACTACTTTTTTAAAAAAGTGGGCAGAATTCTTGTGTATGTATATTTGTGTGTACAGTATGTGTATGTGTG
TATATATATATATTATATATATAGATAATATATAAATATTTTTTTTAAGGAGAAACTAGAATGTTTAGCTAGAAAATTCCACAGCCTGTG
AAGAAATATTTCAAAATGGCCATAAAGGAGGTAAAAATGAAAACCATAACCTAACTTTTATAGAGGCTTTATCTTTAATTTAACGATGTG
CGGAGGACTTTCTTGCTTGAATCTGTTCCGGGCTGTCTGCTCTGTCCATCAAATGGGCAGGTCTGGAATGGGGCACCTTCGGCCGTTCAG
AAGTGGCCTGAACAGAATGCTGGAACCCAGGCTGGACTCGGACACACTAAGGTTTTGATTTTGAATTTCAGCCTTATTAGAAGATCTAAC
CTAAGAGTAAGCTAACCACAGGGATTCTTTTGTAGAACACTTTTTATGCAGATGAAGCTATTTTTTCCAGCAAGTAGATTCTTCCAGTTT
TTCCAAGGAGTAATTTCCCCGAATTGGCATACCACGGCGTGGACAGCTGATATTTCACCCAGCTGCTGGCTTGTGGGTGTGGCTCTTTGC
TTTATATATATATACACACATGTGAGTCTGGCTGGGCTGGTATTTTGTTTGATCTTCCTGGAAATGAGCAGTGACTAACGCTCACATAAC
TGGTTTTTTTTTTATCTGGGCTGATGAATACATTTACCTAAGAAACTCATTTCGTTTTACTTAAGAGGGGAAGTGCAGTTTTCTTTTGGC
AGTTCAGAATCCAAGCACTTGATTTGCTGGGTTTGGAAAACTCCTTTTTTGGCCTTCTATGTGCTTAGCCATAACAATTCCATTAAGCAA
GAAGGTAAGCAAAAGACAAAAAAAAAAAAAGGAAAAAAAAAAACTTGCACTGGCTTGTCTCACTTACGAAACATGTCGGAGCTGTTTGCC
TGGGTGGGGCTGGGTACCGTACCTGTCAATGCCTGTGATTTTCATAATTAGCACGTACATAAAGAAGTACATTCTGTTCAGGTGATAACT
GAGCCTCAATCAAGCAGAAACTTTTTGCTTGAAATTAAAAAAAAATTTCTATTAGTGAAATTTCTTTTTTTTTTTTTTTTGGAAGCACCC
TGTTATCTAAAGAATCTTTGTAAGATTTTTGTAAAATTTTGTTTTACAAGATTTTATTTGAAATTGTTTTTTGCAAGATTGTTATATTTC
TGTATGAATGTATTTTTTATTGGAATAACATAAAAGAATTCTTATCAGCATCTTGAGTCTGGTTGTTTTTTTTGGGGGAAGGGGGTTGTT
GGAACAGATTCCTCCTGCATTCATCACCCTGGCTTCCTCCTGGGGGCAAATCTTCATTGAGCAACCCTGAGAACAACTCACCGACCTCAG
CCCCTTCCTCTTTCCACAGCCTGTCCTGGGAGCTGGAGAGGATGTCAGCGAGCCTGACATTGCCCTCCCTGAATGCATCAAATACTCTTC
TCCAAGGACTGACAAAAACAACCCCCCGGCTGTGGGCACAGTAGGGAACCATGCCGGTTTGATCTTCCATTGCTCAAGCCAGGGAATGCA
TTGCAGAGGCACCTGCACAACGACAAACTTGAGTGTTTCCCTGCCACTTCTGTGCCTCCACAGCCTGCTCCAGTTCCGCAGCTAGAGCTG
GGCCTACCTTCCCCAGCCAGCCCTGCCACACACCTGGCTGAGGCATGTCTGGGAGGGGTGGAGGAGGCAGAGGGACTCCAGGCCAGAGGG

>101106_101106_1_ZFPM1-KLF6_ZFPM1_chr16_88580928_ENST00000319555_KLF6_chr10_3824407_ENST00000497571_length(amino acids)=482AA_BP=233
MRKAERPRRRRRVRGSGGAGTRPSGSPRARNAGPWPLGPPRQLQRLRGWARGLGARAGAAAETGGRGHERPRGPAAPPPPAAARPGLEAA
AGRARGAGDMSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEE
PGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAR
EKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQL
WGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHF

--------------------------------------------------------------
>101106_101106_2_ZFPM1-KLF6_ZFPM1_chr16_88580928_ENST00000319555_KLF6_chr10_3824407_ENST00000542957_length(transcript)=4892nt_BP=724nt
CGCCGCTCGCCGCCCGCGGGTTCCATTGAGAAAAGCCGAGCGGCCGCGGCGGCGGCGGCGAGTGCGCGGGAGCGGAGGAGCCGGCACCCG
CCCGTCGGGCAGTCCGCGCGCCCGCAACGCAGGACCGTGGCCTCTCGGGCCTCCGCGGCAGCTCCAGCGGCTCCGGGGCTGGGCGCGCGG
GCTGGGGGCGCGGGCCGGGGCGGCCGCGGAGACCGGGGGCCGGGGGCATGAGCGGCCCCGCGGCCCCGCCGCGCCCCCGCCGCCCGCCGC
CGCCCGCCCGGGGCTAGAGGCGGCCGCCGGGAGGGCGCGCGGCGCCGGAGACATGTCCAGGCGGAAACAGAGCAACCCCCGGCAGATCAA
GCGTTCCCTCGGAGACATGGAGGCCAGAGAGGAGGTGCAGTTGGTGGGTGCCAGCCACATGGAGCAAAAGGCCACGGCACCTGAAGCCCC
GAGCCCTCCCAGCGCAGATGTTAACTCACCCCCACCGCTGCCGCCCCCCACATCCCCAGGAGGCCCCAAGGAGCTGGAAGGACAGGAACC
AGAACCCAGGCCCACGGAGGAAGAGCCGGGCAGTCCCTGGAGCGGGCCAGACGAGCTGGAGCCGGTGGTGCAGGATGGGCAGAGGCGCAT
ACGGGCCCGACTCAGCCTCGCCACGGGCCTGTCCTGGGGCCCGTTCCATGGGAGTGTCCAGACCAGAGCCTCATCCCCCAGGCAGGCGGA
GCCGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCT
GTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCC
GAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGC
CAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGA
ACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCC
AGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAA
AAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGTGTTTTTCCAGGTCTGACCACCTGGCCCTGCACATGAAGAGGCACCTCTGA
GGGAGCAGAGAGGTGGATCCTGTAGGCTAAAAGGCTTCCAGGCTGAGAGCCGGCCGTGGAAGGAGGGATGCGTGTTCCAGCCAAAGCATG
CCGTTCTGCACCCTACCCAGTTGCCTCCAGGGCCTCTCCTTGGAAGGTCTTTTGAGGGCTAAAAAGGTCCTGTAAGAAGCGGCATAGCAC
CCGTGGTGCATGGTATGTGGGTGACCCTGGACTCGCCACTGGTACCCGCCCTTCCGAGCGGCGCCTAAGCCTTTGCCGTGAGCATGCACA
CTGAGAATGCTAATGGTTGGGTTGATTGTATGTTGAGGATCTATTACTGACCGTATGATGAGGCCAACTTTTTTTCCTTGTGGTTAGCAA
GACTGCAAGAGATGGAAAAAAAGTAGTTTGAATGTTTTGTGTGTAAGGAGTATACCATGAGATGAGATGACCACCAATCATTTCCTTGGG
GGGAGGGGGTGTCTGCACCTTAGAAAAAAAAAGAAAAATCAAAAAAACAAAAAAACAAAAACAAAAAAAGAAGGAAAATCTTGGAGGGTG
GGCGTGGGAACTCAGGACCCCAGAGTGGCGAGTGGTGTGGGGAGGGAGAGCCTCTCTCCCCCTTTTCTGTGTGAGAGGAACTCTTAGTGT
CTGGTGCAGCTATTAAATGTGCAATGTGTCAAGTAGCTTGTTTTACACGCTACAACATAGCTCATTTGTAACCCATTGTATAAGCTGTGT
ATTTACAAATATAACACAACAATTTAACTTTTCCTTAGAATACAAAAAGTCATGCATGGTCTGGGGAACTATATGCTTTTCCATTTTTAA
GTCAGGACTGCAATACTGATTCCAGTTAATGAGCAGCTAAGATCCAATCTGTCTAATACAGTGACCCCCTAGCCATCCGGGCCTGGCAAT
ATACAATTTTTTTTCCCCTCCAAGTTTGTAACACTCCCCTTCCAGAAAGGCATTGTGCAACACAGGATTATTTTTAAATGATTCTGAATT
TGAATTAACTTTTTGGAGAATTCTGTGATGCCCTTAGAAGAAATTGGACACGTATTGAGTGTCACAAAGCTGGGGCTGGGAATTGCTGGT
CTAATGTTTCATTAGACTTAAGAACCTAAAATTTTTCTCAGTTGGGTGGATAAAACCACTAACGCTTAGAAACTGTTTTCTCATGCAGCT
ATGTTTCTCTTATTTATGCCTTGAGGACTAATTTCTGGTTTTCTAGCTGTTAATGCACTGTTGACCTTCATAATGGTGCCTTACGCAAGC
GATCCCTTCTGTGGGGGTCTCATACAGGGGTGTGGGCGATGCATGCTTTATTAAGGCTCTTGTTTCACCTGGCAGTGTACTGTATCAACG
TATAATACAGAAAAAAAATCTCTTTAAGGTCCTCCTTCACAAAGACATAGAGTGAAACTCCCTTTACATGTCAGTATTTGTTCAACACTT
TAGGCAACTTGACTGTCAGTGTTAAAATGGAAAACAGGAAAATGGAAAAATCTGACCAATTCTGCCACCTTGAGACTTTCATATAGACCT
TGCACAACAATTGTATAGATCACACACCGGCTGTATTTAATATGTAACATTTTCACACATATTAAAGATACAGAAGTATTAAAAAACCCC
CAATGTTAATGTATTTGCTTAAAAGGCACAAGTTTCACATATCTGTCTAGCTATCTGTTGGTAATACAGAAAGTATACTACTTTTTTAAA
AAAGTGGGCAGAATTCTTGTGTATGTATATTTGTGTGTACAGTATGTGTATGTGTGTATATATATATATTATATATATAGATAATATATA
AATATTTTTTTTAAGGAGAAACTAGAATGTTTAGCTAGAAAATTCCACAGCCTGTGAAGAAATATTTCAAAATGGCCATAAAGGAGGTAA
AAATGAAAACCATAACCTAACTTTTATAGAGGCTTTATCTTTAATTTAACGATGTGCGGAGGACTTTCTTGCTTGAATCTGTTCCGGGCT
GTCTGCTCTGTCCATCAAATGGGCAGGTCTGGAATGGGGCACCTTCGGCCGTTCAGAAGTGGCCTGAACAGAATGCTGGAACCCAGGCTG
GACTCGGACACACTAAGGTTTTGATTTTGAATTTCAGCCTTATTAGAAGATCTAACCTAAGAGTAAGCTAACCACAGGGATTCTTTTGTA
GAACACTTTTTATGCAGATGAAGCTATTTTTTCCAGCAAGTAGATTCTTCCAGTTTTTCCAAGGAGTAATTTCCCCGAATTGGCATACCA
CGGCGTGGACAGCTGATATTTCACCCAGCTGCTGGCTTGTGGGTGTGGCTCTTTGCTTTATATATATATACACACATGTGAGTCTGGCTG
GGCTGGTATTTTGTTTGATCTTCCTGGAAATGAGCAGTGACTAACGCTCACATAACTGGTTTTTTTTTTATCTGGGCTGATGAATACATT
TACCTAAGAAACTCATTTCGTTTTACTTAAGAGGGGAAGTGCAGTTTTCTTTTGGCAGTTCAGAATCCAAGCACTTGATTTGCTGGGTTT
GGAAAACTCCTTTTTTGGCCTTCTATGTGCTTAGCCATAACAATTCCATTAAGCAAGAAGGTAAGCAAAAGACAAAAAAAAAAAAAGGAA
AAAAAAAAACTTGCACTGGCTTGTCTCACTTACGAAACATGTCGGAGCTGTTTGCCTGGGTGGGGCTGGGTACCGTACCTGTCAATGCCT
GTGATTTTCATAATTAGCACGTACATAAAGAAGTACATTCTGTTCAGGTGATAACTGAGCCTCAATCAAGCAGAAACTTTTTGCTTGAAA
TTAAAAAAAAATTTCTATTAGTGAAATTTCTTTTTTTTTTTTTTTTGGAAGCACCCTGTTATCTAAAGAATCTTTGTAAGATTTTTGTAA
AATTTTGTTTTACAAGATTTTATTTGAAATTGTTTTTTGCAAGATTGTTATATTTCTGTATGAATGTATTTTTTATTGGAATAACATAAA
AGAATTCTTATCAGCATCTTGAGTCTGGTTGTTTTTTTTGGGGGAAGGGGGTTGTTGGAACAGATTCCTCCTGCATTCATCACCCTGGCT
TCCTCCTGGGGGCAAATCTTCATTGAGCAACCCTGAGAACAACTCACCGACCTCAGCCCCTTCCTCTTTCCACAGCCTGTCCTGGGAGCT
GGAGAGGATGTCAGCGAGCCTGACATTGCCCTCCCTGAATGCATCAAATACTCTTCTCCAAGGACTGACAAAAACAACCCCCCGGCTGTG
GGCACAGTAGGGAACCATGCCGGTTTGATCTTCCATTGCTCAAGCCAGGGAATGCATTGCAGAGGCACCTGCACAACGACAAACTTGAGT
GTTTCCCTGCCACTTCTGTGCCTCCACAGCCTGCTCCAGTTCCGCAGCTAGAGCTGGGCCTACCTTCCCCAGCCAGCCCTGCCACACACC
TGGCTGAGGCATGTCTGGGAGGGGTGGAGGAGGCAGAGGGACTCCAGGCCAGAGGGCTGTTCTCACAACCTCAGCCCACTCTCAGTCAAG

>101106_101106_2_ZFPM1-KLF6_ZFPM1_chr16_88580928_ENST00000319555_KLF6_chr10_3824407_ENST00000542957_length(amino acids)=436AA_BP=233
MRKAERPRRRRRVRGSGGAGTRPSGSPRARNAGPWPLGPPRQLQRLRGWARGLGARAGAAAETGGRGHERPRGPAAPPPPAAARPGLEAA
AGRARGAGDMSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEE
PGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAR
EKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZFPM1-KLF6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ZFPM1	chr16:88580928	chr10:3824407	ENST00000319555	+	4	10	794_800	134.0	1007.0	CTBP2
Hgene	ZFPM1	chr16:88580928	chr10:3824407	ENST00000319555	+	4	10	330_341	134.0	1007.0	TACC3

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZFPM1-KLF6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZFPM1-KLF6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source