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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFPM2-SLC27A2 (FusionGDB2 ID:101124)

Fusion Gene Summary for ZFPM2-SLC27A2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFPM2-SLC27A2
Fusion gene ID: 101124
HgeneTgene
Gene symbol

ZFPM2

SLC27A2

Gene ID

23414

11001

Gene namezinc finger protein, FOG family member 2solute carrier family 27 member 2
SynonymsDIH3|FOG2|SRXY9|ZC2HC11B|ZNF89B|hFOG-2ACSVL1|FACVL1|FATP2|HsT17226|VLACS|VLCS|hFACVL1
Cytomap

8q23.1

15q21.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein ZFPM2FOG-2Friend of GATA2friend of GATA 2friend of GATA protein 2transcription factor GATA4, modulator ofzinc finger protein 89Bzinc finger protein, multitype 2very long-chain acyl-CoA synthetaseFATP-2THCA-CoA ligasearachidonate--CoA ligasefatty acid transport protein 2fatty-acid-coenzyme A ligase, very long-chain 1long-chain-fatty-acid--CoA ligasephytanate--CoA ligasesolute carrier family 27 (fatty acid
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000407775, ENST00000378472, 
ENST00000517361, ENST00000520492, 
ENST00000522296, 		ENST00000544960, 
ENST00000267842, ENST00000380902, 
Fusion gene scores* DoF score17 X 16 X 8=21765 X 3 X 4=60
# samples 185
** MAII scorelog2(18/2176*10)=-3.59560974492067
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFPM2 [Title/Abstract] AND SLC27A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFPM2(106331209)-SLC27A2(50489697), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFPM2

GO:0045892

negative regulation of transcription, DNA-templated

20206639

HgeneZFPM2

GO:0045944

positive regulation of transcription by RNA polymerase II

10438528

TgeneSLC27A2

GO:0001561

fatty acid alpha-oxidation

10198260

TgeneSLC27A2

GO:0001676

long-chain fatty acid metabolic process

22022213

TgeneSLC27A2

GO:0006635

fatty acid beta-oxidation

10198260

TgeneSLC27A2

GO:0006699

bile acid biosynthetic process

11980911

TgeneSLC27A2

GO:0044539

long-chain fatty acid import

22022213

TgeneSLC27A2

GO:0097089

methyl-branched fatty acid metabolic process

10198260


check buttonFusion gene breakpoints across ZFPM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC27A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BX-01AZFPM2chr8

106331209

-SLC27A2chr15

50489697

+
ChimerDB4SARCTCGA-DX-A8BX-01AZFPM2chr8

106331209

+SLC27A2chr15

50489697

+


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Fusion Gene ORF analysis for ZFPM2-SLC27A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000407775ENST00000544960ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
In-frameENST00000407775ENST00000267842ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
In-frameENST00000407775ENST00000380902ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000378472ENST00000267842ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000378472ENST00000380902ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000517361ENST00000267842ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000517361ENST00000380902ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000520492ENST00000267842ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000520492ENST00000380902ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000522296ENST00000267842ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-3CDSENST00000522296ENST00000380902ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-5UTRENST00000378472ENST00000544960ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-5UTRENST00000517361ENST00000544960ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-5UTRENST00000520492ENST00000544960ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+
intron-5UTRENST00000522296ENST00000544960ZFPM2chr8

106331209

+SLC27A2chr15

50489697

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407775ZFPM2chr8106331209+ENST00000267842SLC27A2chr1550489697+19742902501674474
ENST00000407775ZFPM2chr8106331209+ENST00000380902SLC27A2chr1550489697+17982902501515421

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407775ENST00000267842ZFPM2chr8106331209+SLC27A2chr1550489697+0.0006647820.9993352
ENST00000407775ENST00000380902ZFPM2chr8106331209+SLC27A2chr1550489697+0.0003418120.9996582

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Fusion Genomic Features for ZFPM2-SLC27A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZFPM2chr8106331209+SLC27A2chr1550489696+2.22E-050.9999778
ZFPM2chr8106331209+SLC27A2chr1550489696+2.22E-050.9999778

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZFPM2-SLC27A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:106331209/chr15:50489697)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC27A2chr8:106331209chr15:50489697ENST00000267842010222_233159621.0Nucleotide bindingAMP
TgeneSLC27A2chr8:106331209chr15:50489697ENST0000038090209222_233159568.0Nucleotide bindingAMP
TgeneSLC27A2chr8:106331209chr15:50489697ENST00000267842010283_620159621.0Topological domainCytoplasmic
TgeneSLC27A2chr8:106331209chr15:50489697ENST0000038090209283_620159568.0Topological domainCytoplasmic
TgeneSLC27A2chr8:106331209chr15:50489697ENST00000267842010262_282159621.0TransmembraneHelical
TgeneSLC27A2chr8:106331209chr15:50489697ENST0000038090209262_282159568.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18736_740131152.0MotifNuclear localization signal
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+181113_1146131152.0Zinc fingerCCHC FOG-type 5
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18244_277131152.0Zinc fingerCCHC FOG-type 1
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18296_320131152.0Zinc fingerC2H2-type 1
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18335_357131152.0Zinc fingerC2H2-type 2
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18363_385131152.0Zinc fingerC2H2-type 3
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18542_575131152.0Zinc fingerCCHC FOG-type 2
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18681_714131152.0Zinc fingerCCHC FOG-type 3
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18848_881131152.0Zinc fingerCCHC FOG-type 4
TgeneSLC27A2chr8:106331209chr15:50489697ENST00000267842010128_261159621.0Topological domainLumenal
TgeneSLC27A2chr8:106331209chr15:50489697ENST000002678420101_4159621.0Topological domainLumenal
TgeneSLC27A2chr8:106331209chr15:50489697ENST0000026784201028_106159621.0Topological domainCytoplasmic
TgeneSLC27A2chr8:106331209chr15:50489697ENST0000038090209128_261159568.0Topological domainLumenal
TgeneSLC27A2chr8:106331209chr15:50489697ENST00000380902091_4159568.0Topological domainLumenal
TgeneSLC27A2chr8:106331209chr15:50489697ENST000003809020928_106159568.0Topological domainCytoplasmic
TgeneSLC27A2chr8:106331209chr15:50489697ENST00000267842010107_127159621.0TransmembraneHelical
TgeneSLC27A2chr8:106331209chr15:50489697ENST000002678420105_27159621.0TransmembraneHelical
TgeneSLC27A2chr8:106331209chr15:50489697ENST0000038090209107_127159568.0TransmembraneHelical
TgeneSLC27A2chr8:106331209chr15:50489697ENST00000380902095_27159568.0TransmembraneHelical


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Fusion Gene Sequence for ZFPM2-SLC27A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101124_101124_1_ZFPM2-SLC27A2_ZFPM2_chr8_106331209_ENST00000407775_SLC27A2_chr15_50489697_ENST00000267842_length(transcript)=1974nt_BP=290nt
CTCTCCCCCTCCCCTCCTCACTGTCACACTCTCTGTGCCCCCGTCTCTCTTCTCTCATTTGCTTGCTCATCTCCGAACGTGAATCCGCGG
CTCCCGGAGGAGCCCAGCGCCCGGAGCACCTGGAGTCCGGCCGGCGGCGGGCCGAGCCTGGCCAGCGGCGGCGGCGGCGGCGGCGGCGGC
GGGAGCCGAGGGAGCGGCAGCCGCGACCGCGGGCACCGCGGGAGCCCCAGCGGCAGCAGCCGCCGCCGAGATGTCCCGGCGAAAGCAAAG
CAAACCCCGGCAGATCAAACAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGATGTGTCCATCTATTATGTGAG
CAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATCCCAGAGTCATGGAGGTCTGA
AGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTCTTCCAAAAGCAGCCATGATCACTCATCAGCGCATATG
GTATGGAACTGGCCTCACTTTTGTAAGCGGATTGAAGGCAGATGATGTCATCTATATCACTCTGCCCTTTTACCACAGTGCTGCACTACT
GATTGGCATTCACGGATGTATTGTGGCTGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAGCCAGTTTTGGGATGACTGCAGAAA
ATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAAACCAAATGACCGTGATCATAAAGT
GAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGACATATGCATCTATGAGTTCTATGC
TGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAACTACCTACAGAAAAAAATCATAAC
TTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGTCAGAGTTCCCAAAGGTGAAGTTGG
ACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGACAGAGAAGAAAAAACTGAGAGATGT
CTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCATCTATTTCCACGACAGAGTTGGAGA
TACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGATTTTGTCCAAGAAGTAAATGTTTA
TGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCATGAATTTGATGGAAAGAAACTCTT
TCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCATTGAGATCACTGGAACTTTTAAACA
CCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTTGGATGACACAGCAAAAATGTATGT
GCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCTGAAACTCTGAATATTCCCAGGAGGATAACTCAACATTTCCAGAAA
GAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGATTGAAGATTGTGAGGAAATTTTGTAGGAAATTTGCATACCCGTAA
AGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAGATTTAGAGATTATTATTTTTCAGTGTGCACCTACTGTTTGTATTT

>101124_101124_1_ZFPM2-SLC27A2_ZFPM2_chr8_106331209_ENST00000407775_SLC27A2_chr15_50489697_ENST00000267842_length(amino acids)=474AA_BP=9
MSRRKQSKPRQIKQLQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAM
ITHQRIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKP
NDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVR
VPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDF
VQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLD

--------------------------------------------------------------
>101124_101124_2_ZFPM2-SLC27A2_ZFPM2_chr8_106331209_ENST00000407775_SLC27A2_chr15_50489697_ENST00000380902_length(transcript)=1798nt_BP=290nt
CTCTCCCCCTCCCCTCCTCACTGTCACACTCTCTGTGCCCCCGTCTCTCTTCTCTCATTTGCTTGCTCATCTCCGAACGTGAATCCGCGG
CTCCCGGAGGAGCCCAGCGCCCGGAGCACCTGGAGTCCGGCCGGCGGCGGGCCGAGCCTGGCCAGCGGCGGCGGCGGCGGCGGCGGCGGC
GGGAGCCGAGGGAGCGGCAGCCGCGACCGCGGGCACCGCGGGAGCCCCAGCGGCAGCAGCCGCCGCCGAGATGTCCCGGCGAAAGCAAAG
CAAACCCCGGCAGATCAAACAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGATGATGTGTCCATCTATTATGTGAG
CAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACCTATCCCAGAGTCATGGAGGTCTGA
AGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAGCCA
GTTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAAACC
AAATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGACAT
ATGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAACTA
CCTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGTCAG
AGTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGACAGA
GAAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCATCTA
TTTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGATTT
TGTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCATGA
ATTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCATTGA
GATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTTGGA
TGACACAGCAAAAATGTATGTGCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCTGAAACTCTGAATATTCCCAGGAGG
ATAACTCAACATTTCCAGAAAGAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGATTGAAGATTGTGAGGAAATTTTGT
AGGAAATTTGCATACCCGTAAAGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAGATTTAGAGATTATTATTTTTCAGT

>101124_101124_2_ZFPM2-SLC27A2_ZFPM2_chr8_106331209_ENST00000407775_SLC27A2_chr15_50489697_ENST00000380902_length(amino acids)=421AA_BP=9
MSRRKQSKPRQIKQLQAAVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGATLALR
TKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVG
AVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMV
DHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZFPM2-SLC27A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZFPM2chr8:106331209chr15:50489697ENST00000407775+18829_83513.3333333333333341152.0CTBP2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFPM2-SLC27A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZFPM2-SLC27A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource