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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ZFR-MTMR12 (FusionGDB2 ID:101130) |
Fusion Gene Summary for ZFR-MTMR12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFR-MTMR12 | Fusion gene ID: 101130 | Hgene | Tgene | Gene symbol | ZFR | MTMR12 | Gene ID | 51663 | 54545 |
| Gene name | zinc finger RNA binding protein | myotubularin related protein 12 | |
| Synonyms | SPG71|ZFR1 | 3-PAP|PIP3AP | |
| Cytomap | 5p13.3 | 5p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger RNA-binding proteinM-phase phosphoprotein homolog | myotubularin-related protein 123-phosphatase adapter protein3-phosphatase adapter subunitinactive phosphatidylinositol 3-phosphatase 12phosphatidylinositol 3 phosphate 3-phosphatase adapter subunitphosphatidylinositol-3 phosphate 3-phosphatase adapto | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9C0I1 | |
| Ensembl transtripts involved in fusion gene | ENST00000265069, ENST00000510369, | ENST00000510216, ENST00000264934, ENST00000382142, ENST00000280285, | |
| Fusion gene scores | * DoF score | 9 X 7 X 7=441 | 3 X 4 X 3=36 |
| # samples | 13 | 4 | |
| ** MAII score | log2(13/441*10)=-1.76226703252907 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZFR [Title/Abstract] AND MTMR12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MTMR12(32312864)-ZFR(32364381), # samples:2 ZFR(32444335)-MTMR12(32230453), # samples:1 ZFR(32406879)-MTMR12(32276848), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MTMR12-ZFR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ZFR-MTMR12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ZFR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MTMR12 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-EB-A3HV-01A | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| ChimerDB4 | STAD | TCGA-CG-4441-01A | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
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Fusion Gene ORF analysis for ZFR-MTMR12 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000265069 | ENST00000510216 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| 5CDS-intron | ENST00000265069 | ENST00000510216 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| Frame-shift | ENST00000265069 | ENST00000264934 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| Frame-shift | ENST00000265069 | ENST00000382142 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| In-frame | ENST00000265069 | ENST00000264934 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| In-frame | ENST00000265069 | ENST00000280285 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| In-frame | ENST00000265069 | ENST00000280285 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| In-frame | ENST00000265069 | ENST00000382142 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| intron-3CDS | ENST00000510369 | ENST00000264934 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| intron-3CDS | ENST00000510369 | ENST00000264934 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| intron-3CDS | ENST00000510369 | ENST00000280285 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| intron-3CDS | ENST00000510369 | ENST00000280285 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| intron-3CDS | ENST00000510369 | ENST00000382142 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| intron-3CDS | ENST00000510369 | ENST00000382142 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| intron-5UTR | ENST00000510369 | ENST00000510216 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - |
| intron-intron | ENST00000510369 | ENST00000510216 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000265069 | ZFR | chr5 | 32444335 | - | ENST00000280285 | MTMR12 | chr5 | 32230453 | - | 3594 | 240 | 258 | 809 | 183 |
| ENST00000265069 | ZFR | chr5 | 32406879 | - | ENST00000280285 | MTMR12 | chr5 | 32276848 | - | 5920 | 1135 | 103 | 3135 | 1010 |
| ENST00000265069 | ZFR | chr5 | 32406879 | - | ENST00000382142 | MTMR12 | chr5 | 32276848 | - | 6070 | 1135 | 103 | 3297 | 1064 |
| ENST00000265069 | ZFR | chr5 | 32406879 | - | ENST00000264934 | MTMR12 | chr5 | 32276848 | - | 3138 | 1135 | 103 | 2967 | 954 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000265069 | ENST00000280285 | ZFR | chr5 | 32444335 | - | MTMR12 | chr5 | 32230453 | - | 0.61479294 | 0.38520706 |
| ENST00000265069 | ENST00000280285 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - | 0.000307947 | 0.9996921 |
| ENST00000265069 | ENST00000382142 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - | 0.00012808 | 0.99987185 |
| ENST00000265069 | ENST00000264934 | ZFR | chr5 | 32406879 | - | MTMR12 | chr5 | 32276848 | - | 0.001605617 | 0.9983943 |
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Fusion Genomic Features for ZFR-MTMR12 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ZFR-MTMR12 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:32312864/chr5:32364381) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MTMR12 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:11504939, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:23818870}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ZFR | chr5:32406879 | chr5:32276848 | ENST00000265069 | - | 6 | 20 | 36_302 | 344 | 1075.0 | Compositional bias | Note=Ala-rich |
| Tgene | MTMR12 | chr5:32406879 | chr5:32276848 | ENST00000264934 | 0 | 14 | 205_643 | 27 | 638.0 | Domain | Myotubularin phosphatase | |
| Tgene | MTMR12 | chr5:32406879 | chr5:32276848 | ENST00000280285 | 0 | 15 | 205_643 | 27 | 694.0 | Domain | Myotubularin phosphatase | |
| Tgene | MTMR12 | chr5:32406879 | chr5:32276848 | ENST00000382142 | 0 | 16 | 205_643 | 27 | 748.0 | Domain | Myotubularin phosphatase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ZFR | chr5:32444335 | chr5:32230453 | ENST00000265069 | - | 2 | 20 | 36_302 | 45 | 1075.0 | Compositional bias | Note=Ala-rich |
| Hgene | ZFR | chr5:32406879 | chr5:32276848 | ENST00000265069 | - | 6 | 20 | 703_1073 | 344 | 1075.0 | Domain | DZF |
| Hgene | ZFR | chr5:32444335 | chr5:32230453 | ENST00000265069 | - | 2 | 20 | 703_1073 | 45 | 1075.0 | Domain | DZF |
| Tgene | MTMR12 | chr5:32444335 | chr5:32230453 | ENST00000264934 | 12 | 14 | 205_643 | 448 | 638.0 | Domain | Myotubularin phosphatase | |
| Tgene | MTMR12 | chr5:32444335 | chr5:32230453 | ENST00000280285 | 13 | 15 | 205_643 | 504 | 694.0 | Domain | Myotubularin phosphatase | |
| Tgene | MTMR12 | chr5:32444335 | chr5:32230453 | ENST00000382142 | 14 | 16 | 205_643 | 558 | 748.0 | Domain | Myotubularin phosphatase |
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Fusion Gene Sequence for ZFR-MTMR12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >101130_101130_1_ZFR-MTMR12_ZFR_chr5_32406879_ENST00000265069_MTMR12_chr5_32276848_ENST00000264934_length(transcript)=3138nt_BP=1135nt AGTGCGGTCGGAGGCGGCGGTCTGTTCTCCGCTGAGGAGGAGCGGGGCAGAGGAGGGAGGCAGCGGGTGAGAGTTCAGAGTTCAGCAGCA GCAGCCCGAGCCCATGATTCCCATATGCCCTGTAGTTTCTTTCACCTATGTGCCCAGCCGGCTGGGGGAAGATGCCAAAATGGCGACCGG CAACTACTTTGGATTCACCCACAGCGGGGCGGCGGCGGCGGCGGCTGCGGCCCAATATAGCCAGCAGCCAGCTTCGGGTGTAGCCTATTC TCATCCAACTACAGTTGCTAGCTACACTGTCCATCAGGCTCCAGTAGCTGCTCACACAGTTACTGCTGCCTATGCACCAGCAGCCGCCAC AGTTGCAGTTGCCAGGCCTGCTCCAGTAGCTGTTGCAGCTGCTGCAACAGCTGCTGCTTATGGAGGCTACCCCACTGCACACACAGCAAC TGACTATGGTTATACTCAGAGGCAACAAGAAGCACCACCACCACCACCCCCAGCTACTACACAAAACTACCAGGATTCATACTCATATGT AAGGTCCACAGCTCCTGCTGTAGCTTATGATAGTAAGCAATACTACCAACAACCAACAGCAACTGCTGCTGCTGTAGCTGCCGCTGCCCA ACCTCAGCCTTCTGTTGCTGAAACTTACTATCAGACAGCCCCCAAAGCAGGTTACAGCCAAGGTGCAACTCAGTATACTCAAGCCCAGCA AACTCGACAAGTGACAGCCATAAAACCAGCCACACCAAGTCCAGCTACCACTACTTTCTCCATCTATCCTGTATCCTCCACCGTACAGCC AGTAGCAGCTGCGGCTACTGTGGTGCCATCCTATACTCAGAGTGCTACTTACAGTACCACAGCAGTTACATATTCTGGTACGTCTTATTC AGGTTATGAAGCAGCAGTGTATTCAGCTGCATCTTCCTACTATCAACAGCAGCAGCAGCAACAGAAGCAGGCAGCAGCAGCAGCTGCTGC TGCTGCTGCAACAGCTGCCTGGACAGGGACCACCTTTACTAAAAAAGCACCATTCCAAAATAAACAACTGAAACCAAAACAGCCTCCCAA ACCACCACAGATTCACTATTGTGATGTTTGTAAGATCAGCTGTGCTGGACCACAGGAAATTCACACAAACGAAAAGGAAGTAACAGAGAA GGAAGTAACTCTTCACTTGTTGCCAGGTGAACAGCTGCTTTGTGAAGCCAGCACAGTACTGAAGTATGTCCAGGAAGATTCCTGTCAGCA TGGGGTCTATGGGAGGCTTGTCTGCACAGACTTCAAGATTGCCTTCTTGGGTGATGATGAATCTGCATTGGATAATGATGAAACTCAATT TAAGAATAAGGTTATAGGAGAAAATGACATTACACTCCACTGTGTTGATCAGATTTATGGAGTGTTTGATGAGAAAAAGAAAACTCTCTT TGGACAACTGAAGAAATACCCTGAGAAGCTCATCATCCACTGCAAAGACCTTCGAGTGTTCCAGTTTTGTCTGAGGTACACAAAGGAAGA GGAAGTCAAAAGGATTGTCAGTGGCATAATTCATCATACCCAGGCTCCTAAACTGCTTAAACGATTATTTCTGTTTTCCTATGCGACTGC TGCACAAAACAATACAGTCACTGATCCCAAGAACCATACCGTAATGTTTGACACACTTAAGGACTGGTGTTGGGAACTGGAACGGACCAA AGGCAACATGAAGTACAAAGCAGTGAGTGTCAACGAAGGCTATAAAGTCTGTGAGAGATTGCCAGCATACTTTGTTGTCCCCACCCCTCT TCCTGAAGAGAATGTGCAGCGCTTTCAGGGTCATGGCATACCAATATGGTGTTGGTCCTGCCACAATGGAAGTGCCCTTTTGAAAATGTC AGCACTGCCCAAAGAACAGGATGACGGCATTTTACAAATCCAAAAGAGCTTCTTAGATGGAATTTACAAGACCATCCACAGGCCACCCTA TGAAATTGTTAAAACGGAAGACCTGTCAAGCAACTTCCTGTCCCTGCAGGAAATCCAGACTGCATACTCTAAATTTAAACAGCTATTTCT GATAGATAACAGTACTGAATTTTGGGACACAGATATAAAATGGTTTTCTCTGTTGGAAAGTAGCAGCTGGCTTGACATAATCAGACGTTG CCTGAAAAAAGCAATAGAGATTACAGAATGTATGGAAGCACAAAACATGAATGTTCTTCTTTTAGAGGAGAATGCATCCGACCTCTGCTG TCTCATTTCCTCTCTGGTGCAACTGATGATGGACCCCCACTGCAGAACCAGAATTGGTTTCCAGAGCCTCATCCAAAAGGAGTGGGTCAT GGGTGGCCACTGTTTCTTGGATCGCTGCAACCATCTCCGCCAGAACGACAAAGAGGAGCATCAACGACAACTTTCTTTGCCACTTACACA ATCTAAGTCATCTCCCAAAAGAGGATTTTTCAGGGAAGAAACAGATCATTTAATTAAAAACCTTCTGGGCAAGAGAATTAGCAAACTTAT TAATTCTTCTGATGAGCTCCAAGACAACTTTCGAGAGTTCTATGACAGCTGGCATAGCAAGTCCACTGACTACCATGGTTTGTTGTTACC GCATATCGAGGGGCCCGAAATCAAAGTCTGGGCCCAGCGCTACCTACGTTGGATTCCAGAAGCCCAAATCCTAGGTGGTGGCCAAGTGGC CACTCTGAGCAAACTCTTGGAAATGATGGAGGAAGTCCAGAGTTTACAAGAGAAGATCGACGAGAGACACCACAGCCAGCAGGCCCCCCA GGCTGAGGCCCCCTGCCTGCTGAGGAACTCTGCCCGCCTCTCGTCTTTGTTTCCTTTCGCTCTGCTCCAGCGACATTCCTCTAAGCCCGT CTTACCCACCAGTGGCTGGAAAGCTTTGGGAGATGAAGACGATTTGGCCAAACGAGAAGATGAGTTCGTGGACCTAGGGGATGTGTGACC TGTTTGTTGAGTGATTGTGAAAGAGGAATGTGGGAGATTGGGACAGCTGATCCCTGGATTTGTGTCACGCTACAGCTCATGCTGGCTGGG >101130_101130_1_ZFR-MTMR12_ZFR_chr5_32406879_ENST00000265069_MTMR12_chr5_32276848_ENST00000264934_length(amino acids)=954AA_BP=0 MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVA RPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPS VAETYYQTAPKAGYSQGATQYTQAQQTRQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSGTSYSGYEA AVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKAPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQEIHTNEKEVTEKEVTL HLLPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLFGQLK KYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK YKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGIYKTIHRPPYEIVK TEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISS LVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSD ELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATLSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAP -------------------------------------------------------------- >101130_101130_2_ZFR-MTMR12_ZFR_chr5_32406879_ENST00000265069_MTMR12_chr5_32276848_ENST00000280285_length(transcript)=5920nt_BP=1135nt AGTGCGGTCGGAGGCGGCGGTCTGTTCTCCGCTGAGGAGGAGCGGGGCAGAGGAGGGAGGCAGCGGGTGAGAGTTCAGAGTTCAGCAGCA GCAGCCCGAGCCCATGATTCCCATATGCCCTGTAGTTTCTTTCACCTATGTGCCCAGCCGGCTGGGGGAAGATGCCAAAATGGCGACCGG CAACTACTTTGGATTCACCCACAGCGGGGCGGCGGCGGCGGCGGCTGCGGCCCAATATAGCCAGCAGCCAGCTTCGGGTGTAGCCTATTC TCATCCAACTACAGTTGCTAGCTACACTGTCCATCAGGCTCCAGTAGCTGCTCACACAGTTACTGCTGCCTATGCACCAGCAGCCGCCAC AGTTGCAGTTGCCAGGCCTGCTCCAGTAGCTGTTGCAGCTGCTGCAACAGCTGCTGCTTATGGAGGCTACCCCACTGCACACACAGCAAC TGACTATGGTTATACTCAGAGGCAACAAGAAGCACCACCACCACCACCCCCAGCTACTACACAAAACTACCAGGATTCATACTCATATGT AAGGTCCACAGCTCCTGCTGTAGCTTATGATAGTAAGCAATACTACCAACAACCAACAGCAACTGCTGCTGCTGTAGCTGCCGCTGCCCA ACCTCAGCCTTCTGTTGCTGAAACTTACTATCAGACAGCCCCCAAAGCAGGTTACAGCCAAGGTGCAACTCAGTATACTCAAGCCCAGCA AACTCGACAAGTGACAGCCATAAAACCAGCCACACCAAGTCCAGCTACCACTACTTTCTCCATCTATCCTGTATCCTCCACCGTACAGCC AGTAGCAGCTGCGGCTACTGTGGTGCCATCCTATACTCAGAGTGCTACTTACAGTACCACAGCAGTTACATATTCTGGTACGTCTTATTC AGGTTATGAAGCAGCAGTGTATTCAGCTGCATCTTCCTACTATCAACAGCAGCAGCAGCAACAGAAGCAGGCAGCAGCAGCAGCTGCTGC TGCTGCTGCAACAGCTGCCTGGACAGGGACCACCTTTACTAAAAAAGCACCATTCCAAAATAAACAACTGAAACCAAAACAGCCTCCCAA ACCACCACAGATTCACTATTGTGATGTTTGTAAGATCAGCTGTGCTGGACCACAGGAAATTCACACAAACGAAAAGGAAGTAACAGAGAA GGAAGTAACTCTTCACTTGTTGCCAGGTGAACAGCTGCTTTGTGAAGCCAGCACAGTACTGAAGTATGTCCAGGAAGATTCCTGTCAGCA TGGGGTCTATGGGAGGCTTGTCTGCACAGACTTCAAGATTGCCTTCTTGGGTGATGATGAATCTGCATTGGATAATGATGAAACTCAATT TAAGAATAAGGTTATAGGAGAAAATGACATTACACTCCACTGTGTTGATCAGATTTATGGAGTGTTTGATGAGAAAAAGAAAACTCTCTT TGGACAACTGAAGAAATACCCTGAGAAGCTCATCATCCACTGCAAAGACCTTCGAGTGTTCCAGTTTTGTCTGAGGTACACAAAGGAAGA GGAAGTCAAAAGGATTGTCAGTGGCATAATTCATCATACCCAGGCTCCTAAACTGCTTAAACGATTATTTCTGTTTTCCTATGCGACTGC TGCACAAAACAATACAGTCACTGATCCCAAGAACCATACCGTAATGTTTGACACACTTAAGGACTGGTGTTGGGAACTGGAACGGACCAA AGGCAACATGAAGTACAAAGCAGTGAGTGTCAACGAAGGCTATAAAGTCTGTGAGAGATTGCCAGCATACTTTGTTGTCCCCACCCCTCT TCCTGAAGAGAATGTGCAGCGCTTTCAGGGTCATGGCATACCAATATGGTGTTGGTCCTGCCACAATGGAAGTGCCCTTTTGAAAATGTC AGCACTGCCCAAAGAACAGGATGACGGCATTTTACAAATCCAAAAGAGCTTCTTAGATGGAATTTACAAGACCATCCACAGGCCACCCTA TGAAATTGTTAAAACGGAAGACCTGTCAAGCAACTTCCTGTCCCTGCAGGAAATCCAGACTGCATACTCTAAATTTAAACAGCTATTTCT GATAGATAACAGTACTGAATTTTGGGACACAGATATAAAATGGTTTTCTCTGTTGGAAAGTAGCAGCTGGCTTGACATAATCAGACGTTG CCTGAAAAAAGCAATAGAGATTACAGAATGTATGGAAGCACAAAACATGAATGTTCTTCTTTTAGAGGAGAATGCATCCGACCTCTGCTG TCTCATTTCCTCTCTGGTGCAACTGATGATGGACCCCCACTGCAGAACCAGAATTGGTTTCCAGAGCCTCATCCAAAAGGAGTGGGTCAT GGGTGGCCACTGTTTCTTGGATCGCTGCAACCATCTCCGCCAGAACGACAAAGAGGAGGTTCCTGTGTTCCTGCTTTTCCTAGATTGTGT CTGGCAGCTGGTGCACCAGCATCCCCCGGCATTTGAATTCACAGAGACTTACCTGACTGTTTTGTCAGATAGCCTGTATATACCTATTTT TAGCACCTTCTTCTTCAATTCACCTCATCAAAAAGATACTAACATGCATCAACGACAACTTTCTTTGCCACTTACACAATCTAAGTCATC TCCCAAAAGAGGATTTTTCAGGGAAGAAACAGATCATTTAATTAAAAACCTTCTGGGCAAGAGAATTAGCAAACTTATTAATTCTTCTGA TGAGCTCCAAGACAACTTTCGAGAGTTCTATGACAGCTGGCATAGCAAGTCCACTGACTACCATGGTTTGTTGTTACCGCATATCGAGGG GCCCGAAATCAAAGTCTGGGCCCAGCGCTACCTACGTTGGATTCCAGAAGCCCAAATCCTAGGTGGTGGCCAAGTGGCCACTCTGAGCAA ACTCTTGGAAATGATGGAGGAAGTCCAGAGTTTACAAGAGAAGATCGACGAGAGACACCACAGCCAGCAGGCCCCCCAGGCTGAGGCCCC CTGCCTGCTGAGGAACTCTGCCCGCCTCTCGTCTTTGTTTCCTTTCGCTCTGCTCCAGCGACATTCCTCTAAGCCCGTCTTACCCACCAG TGGCTGGAAAGCTTTGGGAGATGAAGACGATTTGGCCAAACGAGAAGATGAGTTCGTGGACCTAGGGGATGTGTGACCTGTTTGTTGAGT GATTGTGAAAGAGGAATGTGGGAGATTGGGACAGCTGATCCCTGGATTTGTGTCACGCTACAGCTCATGCTGGCTGGGTCCTTAGCCCGG CACTCCGTTAGAATAAACCTGGGCCTTCGGGAAAAGAGGTGGCTCTCATTATTTTTCATGATTCTAAAAGACTATGCAATTAAAACCGCA TCTGTAGTATTACTAATTGGAAGGAATTATTACTTGACCCGTAATAGGGTTGTGGCCGTTTTCTGATGCCTAAGTATTATACAGAGCCCA CAATGGCCAGTTTACTACCAGAAAGGGCTTCAGTAAGATATTCTTGGACTTGATACTTTCTTCAGATCCTCTTTGTGCCAAGATAATTTA TCCAGTCATTGGGAATAGTAAGTTTCTGTGTAACCCATCTCAATTATAGAAGCAAGTTCAGCTTTATGTATTTGTATGGGGAGTTGAAGA TTCAGATAGAGGTATTAAGATGTGTGGCATTTACTTAAACCATCACATTTTTTTCTTTCTACGCCCCCTTGCCTGTAAAACACCTGGGAA GTTCCACTGGTGTCATCCATCCTGATGCTTCAGACCACCCTCCCTTCTTCACAGACCGTGTCACTTTGCCTGTGGGTGGGGGCTAGCCAG CCACCACCCTCTTTTCTGTGCTGCCAGCCCCAGGTCTTCCTCCGCCTGCTCCACACCACTCGCCGCTGTCCCTCTGCACTCCCTGCCTTG GTGCGTGTAGTCCCAGTGTCTCACTGCCAAACCTCTTGGTTACGCTGCGGGGATCTGTTTCTTTGCCTGAGATCCTTCCTGAGGAGCGTC CATTCCTCTGGAGTCTCTCCTTGTTTGGAACAAATCGCTTCGCCTTTTTCTACTTGCCTGCTGAAGCTTTGGAGCACTTGTGATTGCAGT TTTCTGCCGCAACCCCTGAGCCGAGTTCCTCACATTCTTTTACCTTTATGGACTGATGGGATTGGGTCACTTTTGAATGTGGCTTTCATA GGAAAGCAGCTTAAACATAAATATCAGAAGTGATGATTATCATATGATACCTCAGTGATTTTAAAAGCCATAGAAGAAACTTGACTATGC CTGGTCACCTTCTTGGATCTGCTGTCTAAATGATATATATATGATATATATGTGATATATATATATCATATATATGATATATATATATAT ATCACATATATATGATATATATATGATATATATATATCACATATATATGATATATATATCATATATATGATATATATTTTTTTTAATGCA GGAAAGTATACTTTGTAAGGAGCAGATTTTTTTGTTCTCAGTGGAACCCTGTCAAATCGCATAAAAGAGGAAAAAAACAAAACTCATTAG AATGTTTTAAATTGAATGTTCGCCTTTTACATATATTTGCTCTTCAGTATGGATCCCAATTTGAATGTTACATGTTCGGAAAAACTTTCA GTTGCTCAAGGGCAATAAGAAAATTTGAGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTCAGGTGGGCGAATT GCTTGAGCCCAGGAGTTCGAGACCAGCCGGGGCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTG CATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGTGGGAGGATCCCGTGAGCCTGGGAGGTGGAGTTTGCAGTGAGCTAAGATCGTGCC ACTGCACTCCGGCCTGGGTGATGGAGCAAGACCTCGTCTCAGAAAATTGGAAACTATTGACTAAGAGAAGTTTCTAGGTTTGCACTGAAT TGTCTTTTGTACATACAGTGAATTGTTTTGCTGTTCTCCCCACTCCATATTAATGCAGGAGCCAGGTTGGTCTGTTAGGATGAACAAAGG TTGAGGGGAGGGCAGGATTCGTGCATCTGGGGGCCAAACACATGTTCCGTCTTGATTGCCTTAAGAGTTACTAGCGAGGTCAGTGTTAGG CTTGCAATAGGGATTTTAAAATACACTAACTAGTTCCTTAGCTACCTTCACATACATTCTATAGGCCTTCTTAAATTAGCACTAACCTCC ACTTCCTTCTCTGCCCCATTGCCTCCCAAATATGCTATGGAGCTATTTTTGTTACCACGTTATAACGTGAATATTTATACAGTAGCCTCT TCAGGCTTTGTAATTTTCATTCCAAAAATGCCCGGTGTGATGCTTTACACTCTACAAAGTATGGTTTAAAGGCACAAGGTCATGGCCTTT GTCATAGCAGTTGAATGTGCATTGACATATTTTTCTATGATTTTTTAAAATTACAATAGAAAAATAAGCTGTTGTAACGTGTAAGGTCAT GACAATTTTTGTATTTATATTTGAAATCAGATTTCTATAACTCGTATTTGTGTACAGAATTCTCAATGGATTTATATATTGTGAAATTTT TATCTGAGATTGGGATGTGGATTATGCTTAACAGTGAGAGCTGAAATGAGACCATTTACTTTGTTTAAAATGCTGTACTGTGCAAGTTTG GAAATGTAAATTAATTTACTGTATATAATATCTTGAGTTTGTTTATACCTCCAAGTTTTTACACTGAAGATAAACTAGCTTTAATTCAAA ACTTTTTTTTTCTTTATAAGGGAATAAGCTGTTGAGCTAAACCTGTATACTTGTGCTTTTTATTTTCTGGATGCACAATGAAAGTTTATA >101130_101130_2_ZFR-MTMR12_ZFR_chr5_32406879_ENST00000265069_MTMR12_chr5_32276848_ENST00000280285_length(amino acids)=1010AA_BP=0 MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVA RPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPS VAETYYQTAPKAGYSQGATQYTQAQQTRQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSGTSYSGYEA AVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKAPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQEIHTNEKEVTEKEVTL HLLPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLFGQLK KYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK YKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGIYKTIHRPPYEIVK TEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISS LVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFF FNSPHQKDTNMHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIK VWAQRYLRWIPEAQILGGGQVATLSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVLPTSGWKA -------------------------------------------------------------- >101130_101130_3_ZFR-MTMR12_ZFR_chr5_32406879_ENST00000265069_MTMR12_chr5_32276848_ENST00000382142_length(transcript)=6070nt_BP=1135nt AGTGCGGTCGGAGGCGGCGGTCTGTTCTCCGCTGAGGAGGAGCGGGGCAGAGGAGGGAGGCAGCGGGTGAGAGTTCAGAGTTCAGCAGCA GCAGCCCGAGCCCATGATTCCCATATGCCCTGTAGTTTCTTTCACCTATGTGCCCAGCCGGCTGGGGGAAGATGCCAAAATGGCGACCGG CAACTACTTTGGATTCACCCACAGCGGGGCGGCGGCGGCGGCGGCTGCGGCCCAATATAGCCAGCAGCCAGCTTCGGGTGTAGCCTATTC TCATCCAACTACAGTTGCTAGCTACACTGTCCATCAGGCTCCAGTAGCTGCTCACACAGTTACTGCTGCCTATGCACCAGCAGCCGCCAC AGTTGCAGTTGCCAGGCCTGCTCCAGTAGCTGTTGCAGCTGCTGCAACAGCTGCTGCTTATGGAGGCTACCCCACTGCACACACAGCAAC TGACTATGGTTATACTCAGAGGCAACAAGAAGCACCACCACCACCACCCCCAGCTACTACACAAAACTACCAGGATTCATACTCATATGT AAGGTCCACAGCTCCTGCTGTAGCTTATGATAGTAAGCAATACTACCAACAACCAACAGCAACTGCTGCTGCTGTAGCTGCCGCTGCCCA ACCTCAGCCTTCTGTTGCTGAAACTTACTATCAGACAGCCCCCAAAGCAGGTTACAGCCAAGGTGCAACTCAGTATACTCAAGCCCAGCA AACTCGACAAGTGACAGCCATAAAACCAGCCACACCAAGTCCAGCTACCACTACTTTCTCCATCTATCCTGTATCCTCCACCGTACAGCC AGTAGCAGCTGCGGCTACTGTGGTGCCATCCTATACTCAGAGTGCTACTTACAGTACCACAGCAGTTACATATTCTGGTACGTCTTATTC AGGTTATGAAGCAGCAGTGTATTCAGCTGCATCTTCCTACTATCAACAGCAGCAGCAGCAACAGAAGCAGGCAGCAGCAGCAGCTGCTGC TGCTGCTGCAACAGCTGCCTGGACAGGGACCACCTTTACTAAAAAAGCACCATTCCAAAATAAACAACTGAAACCAAAACAGCCTCCCAA ACCACCACAGATTCACTATTGTGATGTTTGTAAGATCAGCTGTGCTGGACCACAGGAAATTCACACAAACGAAAAGGAAGTAACAGAGAA GGAAGTAACTCTTCACTTGTTGCCAGGTGAACAGCTGCTTTGTGAAGCCAGCACAGTACTGAAGTATGTCCAGGAAGATTCCTGTCAGCA TGGGGTCTATGGGAGGCTTGTCTGCACAGACTTCAAGATTGCCTTCTTGGGTGATGATGAATCTGCATTGGATAATGATGAAACTCAATT TAAGAATAAGGTTATAGGAGAAAATGACATTACACTCCACTGTGTTGATCAGATTTATGGAGTGTTTGATGAGAAAAAGAAAACTCTCTT TGGACAACTGAAGAAATACCCTGAGAAGCTCATCATCCACTGCAAAGACCTTCGAGTGTTCCAGTTTTGTCTGAGGTACACAAAGGAAGA GGAAGTCAAAAGGATTGTCAGTGGCATAATTCATCATACCCAGGCTCCTAAACTGCTTAAACGATTATTTCTGTTTTCCTATGCGACTGC TGCACAAAACAATACAGTCACTGATCCCAAGAACCATACCGTAATGTTTGACACACTTAAGGACTGGTGTTGGGAACTGGAACGGACCAA AGGCAACATGAAGTACAAAGCAGTGAGTGTCAACGAAGGCTATAAAGTCTGTGAGAGATTGCCAGCATACTTTGTTGTCCCCACCCCTCT TCCTGAAGAGAATGTGCAGCGCTTTCAGGGTCATGGCATACCAATATGGTGTTGGTCCTGCCACAATGGAAGTGCCCTTTTGAAAATGTC AGCACTGCCCAAAGAACAGGATGACGGCATTTTACAAATCCAAAAGAGCTTCTTAGATGGAATTTACAAGACCATCCACAGGCCACCCTA TGAAATTGTTAAAACGGAAGACCTGTCAAGCAACTTCCTGTCCCTGCAGGAAATCCAGACTGCATACTCTAAATTTAAACAGCTATTTCT GATAGATAACAGTACTGAATTTTGGGACACAGATATAAAATGGTTTTCTCTGTTGGAAAGTAGCAGCTGGCTTGACATAATCAGACGTTG CCTGAAAAAAGCAATAGAGATTACAGAATGTATGGAAGCACAAAACATGAATGTTCTTCTTTTAGAGGAGAATGCATCCGACCTCTGCTG TCTCATTTCCTCTCTGGTGCAACTGATGATGGACCCCCACTGCAGAACCAGAATTGGTTTCCAGAGCCTCATCCAAAAGGAGTGGGTCAT GGGTGGCCACTGTTTCTTGGATCGCTGCAACCATCTCCGCCAGAACGACAAAGAGGAGGTTCCTGTGTTCCTGCTTTTCCTAGATTGTGT CTGGCAGCTGGTGCACCAGCATCCCCCGGCATTTGAATTCACAGAGACTTACCTGACTGTTTTGTCAGATAGCCTGTATATACCTATTTT TAGCACCTTCTTCTTCAATTCACCTCATCAAAAAGATACTAACATGGGTAGAGAAGGCCAGGATACACAAAGCAAGCCTTTGAATCTGCT CACCGTGTGGGATTGGTCGGTGCAGTTTGAACCCAAAGCCCAGACATTGCTCAAAAACCCTCTTTATGTGGAAAAGCCAAAACTGGACAA AGGCCAACGGAAAGGAATGCGCTTCAAACATCAACGACAACTTTCTTTGCCACTTACACAATCTAAGTCATCTCCCAAAAGAGGATTTTT CAGGGAAGAAACAGATCATTTAATTAAAAACCTTCTGGGCAAGAGAATTAGCAAACTTATTAATTCTTCTGATGAGCTCCAAGACAACTT TCGAGAGTTCTATGACAGCTGGCATAGCAAGTCCACTGACTACCATGGTTTGTTGTTACCGCATATCGAGGGGCCCGAAATCAAAGTCTG GGCCCAGCGCTACCTACGTTGGATTCCAGAAGCCCAAATCCTAGGTGGTGGCCAAGTGGCCACTCTGAGCAAACTCTTGGAAATGATGGA GGAAGTCCAGAGTTTACAAGAGAAGATCGACGAGAGACACCACAGCCAGCAGGCCCCCCAGGCTGAGGCCCCCTGCCTGCTGAGGAACTC TGCCCGCCTCTCGTCTTTGTTTCCTTTCGCTCTGCTCCAGCGACATTCCTCTAAGCCCGTCTTACCCACCAGTGGCTGGAAAGCTTTGGG AGATGAAGACGATTTGGCCAAACGAGAAGATGAGTTCGTGGACCTAGGGGATGTGTGACCTGTTTGTTGAGTGATTGTGAAAGAGGAATG TGGGAGATTGGGACAGCTGATCCCTGGATTTGTGTCACGCTACAGCTCATGCTGGCTGGGTCCTTAGCCCGGCACTCCGTTAGAATAAAC CTGGGCCTTCGGGAAAAGAGGTGGCTCTCATTATTTTTCATGATTCTAAAAGACTATGCAATTAAAACCGCATCTGTAGTATTACTAATT GGAAGGAATTATTACTTGACCCGTAATAGGGTTGTGGCCGTTTTCTGATGCCTAAGTATTATACAGAGCCCACAATGGCCAGTTTACTAC CAGAAAGGGCTTCAGTAAGATATTCTTGGACTTGATACTTTCTTCAGATCCTCTTTGTGCCAAGATAATTTATCCAGTCATTGGGAATAG TAAGTTTCTGTGTAACCCATCTCAATTATAGAAGCAAGTTCAGCTTTATGTATTTGTATGGGGAGTTGAAGATTCAGATAGAGGTATTAA GATGTGTGGCATTTACTTAAACCATCACATTTTTTTCTTTCTACGCCCCCTTGCCTGTAAAACACCTGGGAAGTTCCACTGGTGTCATCC ATCCTGATGCTTCAGACCACCCTCCCTTCTTCACAGACCGTGTCACTTTGCCTGTGGGTGGGGGCTAGCCAGCCACCACCCTCTTTTCTG TGCTGCCAGCCCCAGGTCTTCCTCCGCCTGCTCCACACCACTCGCCGCTGTCCCTCTGCACTCCCTGCCTTGGTGCGTGTAGTCCCAGTG TCTCACTGCCAAACCTCTTGGTTACGCTGCGGGGATCTGTTTCTTTGCCTGAGATCCTTCCTGAGGAGCGTCCATTCCTCTGGAGTCTCT CCTTGTTTGGAACAAATCGCTTCGCCTTTTTCTACTTGCCTGCTGAAGCTTTGGAGCACTTGTGATTGCAGTTTTCTGCCGCAACCCCTG AGCCGAGTTCCTCACATTCTTTTACCTTTATGGACTGATGGGATTGGGTCACTTTTGAATGTGGCTTTCATAGGAAAGCAGCTTAAACAT AAATATCAGAAGTGATGATTATCATATGATACCTCAGTGATTTTAAAAGCCATAGAAGAAACTTGACTATGCCTGGTCACCTTCTTGGAT CTGCTGTCTAAATGATATATATATGATATATATGTGATATATATATATCATATATATGATATATATATATATATCACATATATATGATAT ATATATGATATATATATATCACATATATATGATATATATATCATATATATGATATATATTTTTTTTAATGCAGGAAAGTATACTTTGTAA GGAGCAGATTTTTTTGTTCTCAGTGGAACCCTGTCAAATCGCATAAAAGAGGAAAAAAACAAAACTCATTAGAATGTTTTAAATTGAATG TTCGCCTTTTACATATATTTGCTCTTCAGTATGGATCCCAATTTGAATGTTACATGTTCGGAAAAACTTTCAGTTGCTCAAGGGCAATAA GAAAATTTGAGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTCAGGTGGGCGAATTGCTTGAGCCCAGGAGTTC GAGACCAGCCGGGGCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAGTCCCAGC TACTCGGGAGGCTGAGGTGGGAGGATCCCGTGAGCCTGGGAGGTGGAGTTTGCAGTGAGCTAAGATCGTGCCACTGCACTCCGGCCTGGG TGATGGAGCAAGACCTCGTCTCAGAAAATTGGAAACTATTGACTAAGAGAAGTTTCTAGGTTTGCACTGAATTGTCTTTTGTACATACAG TGAATTGTTTTGCTGTTCTCCCCACTCCATATTAATGCAGGAGCCAGGTTGGTCTGTTAGGATGAACAAAGGTTGAGGGGAGGGCAGGAT TCGTGCATCTGGGGGCCAAACACATGTTCCGTCTTGATTGCCTTAAGAGTTACTAGCGAGGTCAGTGTTAGGCTTGCAATAGGGATTTTA AAATACACTAACTAGTTCCTTAGCTACCTTCACATACATTCTATAGGCCTTCTTAAATTAGCACTAACCTCCACTTCCTTCTCTGCCCCA TTGCCTCCCAAATATGCTATGGAGCTATTTTTGTTACCACGTTATAACGTGAATATTTATACAGTAGCCTCTTCAGGCTTTGTAATTTTC ATTCCAAAAATGCCCGGTGTGATGCTTTACACTCTACAAAGTATGGTTTAAAGGCACAAGGTCATGGCCTTTGTCATAGCAGTTGAATGT GCATTGACATATTTTTCTATGATTTTTTAAAATTACAATAGAAAAATAAGCTGTTGTAACGTGTAAGGTCATGACAATTTTTGTATTTAT ATTTGAAATCAGATTTCTATAACTCGTATTTGTGTACAGAATTCTCAATGGATTTATATATTGTGAAATTTTTATCTGAGATTGGGATGT GGATTATGCTTAACAGTGAGAGCTGAAATGAGACCATTTACTTTGTTTAAAATGCTGTACTGTGCAAGTTTGGAAATGTAAATTAATTTA CTGTATATAATATCTTGAGTTTGTTTATACCTCCAAGTTTTTACACTGAAGATAAACTAGCTTTAATTCAAAACTTTTTTTTTCTTTATA AGGGAATAAGCTGTTGAGCTAAACCTGTATACTTGTGCTTTTTATTTTCTGGATGCACAATGAAAGTTTATACTTGTATCTCACTGCATC >101130_101130_3_ZFR-MTMR12_ZFR_chr5_32406879_ENST00000265069_MTMR12_chr5_32276848_ENST00000382142_length(amino acids)=1064AA_BP=0 MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVA RPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPS VAETYYQTAPKAGYSQGATQYTQAQQTRQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSGTSYSGYEA AVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKAPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQEIHTNEKEVTEKEVTL HLLPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKTLFGQLK KYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK YKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGIYKTIHRPPYEIVK TEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISS LVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFF FNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREET DHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATLSKLLEMMEEVQS -------------------------------------------------------------- >101130_101130_4_ZFR-MTMR12_ZFR_chr5_32444335_ENST00000265069_MTMR12_chr5_32230453_ENST00000280285_length(transcript)=3594nt_BP=240nt AGTGCGGTCGGAGGCGGCGGTCTGTTCTCCGCTGAGGAGGAGCGGGGCAGAGGAGGGAGGCAGCGGGTGAGAGTTCAGAGTTCAGCAGCA GCAGCCCGAGCCCATGATTCCCATATGCCCTGTAGTTTCTTTCACCTATGTGCCCAGCCGGCTGGGGGAAGATGCCAAAATGGCGACCGG CAACTACTTTGGATTCACCCACAGCGGGGCGGCGGCGGCGGCGGCTGCGGCCCAATATAGCATCAACGACAACTTTCTTTGCCACTTACA CAATCTAAGTCATCTCCCAAAAGAGGATTTTTCAGGGAAGAAACAGATCATTTAATTAAAAACCTTCTGGGCAAGAGAATTAGCAAACTT ATTAATTCTTCTGATGAGCTCCAAGACAACTTTCGAGAGTTCTATGACAGCTGGCATAGCAAGTCCACTGACTACCATGGTTTGTTGTTA CCGCATATCGAGGGGCCCGAAATCAAAGTCTGGGCCCAGCGCTACCTACGTTGGATTCCAGAAGCCCAAATCCTAGGTGGTGGCCAAGTG GCCACTCTGAGCAAACTCTTGGAAATGATGGAGGAAGTCCAGAGTTTACAAGAGAAGATCGACGAGAGACACCACAGCCAGCAGGCCCCC CAGGCTGAGGCCCCCTGCCTGCTGAGGAACTCTGCCCGCCTCTCGTCTTTGTTTCCTTTCGCTCTGCTCCAGCGACATTCCTCTAAGCCC GTCTTACCCACCAGTGGCTGGAAAGCTTTGGGAGATGAAGACGATTTGGCCAAACGAGAAGATGAGTTCGTGGACCTAGGGGATGTGTGA CCTGTTTGTTGAGTGATTGTGAAAGAGGAATGTGGGAGATTGGGACAGCTGATCCCTGGATTTGTGTCACGCTACAGCTCATGCTGGCTG GGTCCTTAGCCCGGCACTCCGTTAGAATAAACCTGGGCCTTCGGGAAAAGAGGTGGCTCTCATTATTTTTCATGATTCTAAAAGACTATG CAATTAAAACCGCATCTGTAGTATTACTAATTGGAAGGAATTATTACTTGACCCGTAATAGGGTTGTGGCCGTTTTCTGATGCCTAAGTA TTATACAGAGCCCACAATGGCCAGTTTACTACCAGAAAGGGCTTCAGTAAGATATTCTTGGACTTGATACTTTCTTCAGATCCTCTTTGT GCCAAGATAATTTATCCAGTCATTGGGAATAGTAAGTTTCTGTGTAACCCATCTCAATTATAGAAGCAAGTTCAGCTTTATGTATTTGTA TGGGGAGTTGAAGATTCAGATAGAGGTATTAAGATGTGTGGCATTTACTTAAACCATCACATTTTTTTCTTTCTACGCCCCCTTGCCTGT AAAACACCTGGGAAGTTCCACTGGTGTCATCCATCCTGATGCTTCAGACCACCCTCCCTTCTTCACAGACCGTGTCACTTTGCCTGTGGG TGGGGGCTAGCCAGCCACCACCCTCTTTTCTGTGCTGCCAGCCCCAGGTCTTCCTCCGCCTGCTCCACACCACTCGCCGCTGTCCCTCTG CACTCCCTGCCTTGGTGCGTGTAGTCCCAGTGTCTCACTGCCAAACCTCTTGGTTACGCTGCGGGGATCTGTTTCTTTGCCTGAGATCCT TCCTGAGGAGCGTCCATTCCTCTGGAGTCTCTCCTTGTTTGGAACAAATCGCTTCGCCTTTTTCTACTTGCCTGCTGAAGCTTTGGAGCA CTTGTGATTGCAGTTTTCTGCCGCAACCCCTGAGCCGAGTTCCTCACATTCTTTTACCTTTATGGACTGATGGGATTGGGTCACTTTTGA ATGTGGCTTTCATAGGAAAGCAGCTTAAACATAAATATCAGAAGTGATGATTATCATATGATACCTCAGTGATTTTAAAAGCCATAGAAG AAACTTGACTATGCCTGGTCACCTTCTTGGATCTGCTGTCTAAATGATATATATATGATATATATGTGATATATATATATCATATATATG ATATATATATATATATCACATATATATGATATATATATGATATATATATATCACATATATATGATATATATATCATATATATGATATATA TTTTTTTTAATGCAGGAAAGTATACTTTGTAAGGAGCAGATTTTTTTGTTCTCAGTGGAACCCTGTCAAATCGCATAAAAGAGGAAAAAA ACAAAACTCATTAGAATGTTTTAAATTGAATGTTCGCCTTTTACATATATTTGCTCTTCAGTATGGATCCCAATTTGAATGTTACATGTT CGGAAAAACTTTCAGTTGCTCAAGGGCAATAAGAAAATTTGAGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCT CAGGTGGGCGAATTGCTTGAGCCCAGGAGTTCGAGACCAGCCGGGGCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGC TGGGTGTGGTGGTGCATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGTGGGAGGATCCCGTGAGCCTGGGAGGTGGAGTTTGCAGTGA GCTAAGATCGTGCCACTGCACTCCGGCCTGGGTGATGGAGCAAGACCTCGTCTCAGAAAATTGGAAACTATTGACTAAGAGAAGTTTCTA GGTTTGCACTGAATTGTCTTTTGTACATACAGTGAATTGTTTTGCTGTTCTCCCCACTCCATATTAATGCAGGAGCCAGGTTGGTCTGTT AGGATGAACAAAGGTTGAGGGGAGGGCAGGATTCGTGCATCTGGGGGCCAAACACATGTTCCGTCTTGATTGCCTTAAGAGTTACTAGCG AGGTCAGTGTTAGGCTTGCAATAGGGATTTTAAAATACACTAACTAGTTCCTTAGCTACCTTCACATACATTCTATAGGCCTTCTTAAAT TAGCACTAACCTCCACTTCCTTCTCTGCCCCATTGCCTCCCAAATATGCTATGGAGCTATTTTTGTTACCACGTTATAACGTGAATATTT ATACAGTAGCCTCTTCAGGCTTTGTAATTTTCATTCCAAAAATGCCCGGTGTGATGCTTTACACTCTACAAAGTATGGTTTAAAGGCACA AGGTCATGGCCTTTGTCATAGCAGTTGAATGTGCATTGACATATTTTTCTATGATTTTTTAAAATTACAATAGAAAAATAAGCTGTTGTA ACGTGTAAGGTCATGACAATTTTTGTATTTATATTTGAAATCAGATTTCTATAACTCGTATTTGTGTACAGAATTCTCAATGGATTTATA TATTGTGAAATTTTTATCTGAGATTGGGATGTGGATTATGCTTAACAGTGAGAGCTGAAATGAGACCATTTACTTTGTTTAAAATGCTGT ACTGTGCAAGTTTGGAAATGTAAATTAATTTACTGTATATAATATCTTGAGTTTGTTTATACCTCCAAGTTTTTACACTGAAGATAAACT AGCTTTAATTCAAAACTTTTTTTTTCTTTATAAGGGAATAAGCTGTTGAGCTAAACCTGTATACTTGTGCTTTTTATTTTCTGGATGCAC >101130_101130_4_ZFR-MTMR12_ZFR_chr5_32444335_ENST00000265069_MTMR12_chr5_32230453_ENST00000280285_length(amino acids)=183AA_BP= MPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILG GGQVATLSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVLPTSGWKALGDEDDLAKREDEFVDL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ZFR-MTMR12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ZFR-MTMR12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ZFR-MTMR12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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