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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFX-EIF2S3 (FusionGDB2 ID:101140)

Fusion Gene Summary for ZFX-EIF2S3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFX-EIF2S3
Fusion gene ID: 101140
HgeneTgene
Gene symbol

ZFX

EIF2S3

Gene ID

7543

1968

Gene namezinc finger protein X-linkedeukaryotic translation initiation factor 2 subunit gamma
SynonymsZNF926EIF2|EIF2G|EIF2gamma|MEHMO|MRXSBRK|eIF-2gA
Cytomap

Xp22.11

Xp22.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger X-chromosomal proteinX-linked zinc finger proteineukaryotic translation initiation factor 2 subunit 3eIF-2-gamma XeIF-2gXeukaryotic translation initiation factor 2 subunit gamma Xeukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaeukaryotic translation initiation factor 2G
Modification date2020031320200313
UniProtAcc.

P41091

Ensembl transtripts involved in fusion geneENST00000304543, ENST00000379177, 
ENST00000379188, ENST00000539115, 
ENST00000338565, ENST00000459724, 
ENST00000540034, 		ENST00000253039, 
ENST00000460032, 
Fusion gene scores* DoF score8 X 7 X 7=3926 X 7 X 4=168
# samples 107
** MAII scorelog2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFX [Title/Abstract] AND EIF2S3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFX(24167911)-EIF2S3(24089674), # samples:1
ZFX(24167911)-EIF2S3(24089675), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF2S3

GO:0006413

translational initiation

10900014


check buttonFusion gene breakpoints across ZFX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF2S3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AX-A3G4-01AZFXchrX

24167911

+EIF2S3chrX

24089675

+
ChimerDB4UCECTCGA-AX-A3G4ZFXchrX

24167911

+EIF2S3chrX

24089674

+


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Fusion Gene ORF analysis for ZFX-EIF2S3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000304543ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-3CDSENST00000304543ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089674

+
5UTR-3CDSENST00000379177ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-3CDSENST00000379177ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089674

+
5UTR-3CDSENST00000379188ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-3CDSENST00000379188ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089674

+
5UTR-3CDSENST00000539115ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-3CDSENST00000539115ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089674

+
5UTR-intronENST00000304543ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-intronENST00000304543ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089674

+
5UTR-intronENST00000379177ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-intronENST00000379177ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089674

+
5UTR-intronENST00000379188ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-intronENST00000379188ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089674

+
5UTR-intronENST00000539115ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089675

+
5UTR-intronENST00000539115ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089674

+
intron-3CDSENST00000338565ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089675

+
intron-3CDSENST00000338565ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089674

+
intron-3CDSENST00000459724ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089675

+
intron-3CDSENST00000459724ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089674

+
intron-3CDSENST00000540034ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089675

+
intron-3CDSENST00000540034ENST00000253039ZFXchrX

24167911

+EIF2S3chrX

24089674

+
intron-intronENST00000338565ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089675

+
intron-intronENST00000338565ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089674

+
intron-intronENST00000459724ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089675

+
intron-intronENST00000459724ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089674

+
intron-intronENST00000540034ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089675

+
intron-intronENST00000540034ENST00000460032ZFXchrX

24167911

+EIF2S3chrX

24089674

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZFX-EIF2S3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZFXchrX24167911+EIF2S3chrX24089674+0.0155214620.9844786
ZFXchrX24167911+EIF2S3chrX24089674+0.0155214620.9844786
ZFXchrX24167911+EIF2S3chrX24089674+0.0155214620.9844786
ZFXchrX24167911+EIF2S3chrX24089674+0.0155214620.9844786

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZFX-EIF2S3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24167911/:24089674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF2S3

P41091

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). {ECO:0000250|UniProtKB:P32481, ECO:0000250|UniProtKB:Q9Z0N1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZFX-EIF2S3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZFX-EIF2S3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFX-EIF2S3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZFX-EIF2S3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource