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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFYVE16-BDP1 (FusionGDB2 ID:101151)

Fusion Gene Summary for ZFYVE16-BDP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFYVE16-BDP1
Fusion gene ID: 101151
HgeneTgene
Gene symbol

ZFYVE16

BDP1

Gene ID

9765

55814

Gene namezinc finger FYVE-type containing 16B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
SynonymsPPP1R69DFNB112|HSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR
Cytomap

5q14.1

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger FYVE domain-containing protein 16endosome-associated FYVE-domain proteinprotein phosphatase 1, regulatory subunit 69zinc finger, FYVE domain containing 16transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear
Modification date2020032020200313
UniProtAcc.

A6H8Y1

Ensembl transtripts involved in fusion geneENST00000338008, ENST00000505560, 
ENST00000510158, ENST00000512442, 
ENST00000358731, ENST00000380675, 
Fusion gene scores* DoF score6 X 6 X 2=724 X 5 X 3=60
# samples 65
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFYVE16 [Title/Abstract] AND BDP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFYVE16(79735851)-BDP1(70848943), # samples:1
Anticipated loss of major functional domain due to fusion event.ZFYVE16-BDP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZFYVE16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BDP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4449-01AZFYVE16chr5

79735851

-BDP1chr5

70848943

+


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Fusion Gene ORF analysis for ZFYVE16-BDP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000338008ENST00000358731ZFYVE16chr5

79735851

-BDP1chr5

70848943

+
Frame-shiftENST00000505560ENST00000358731ZFYVE16chr5

79735851

-BDP1chr5

70848943

+
Frame-shiftENST00000510158ENST00000358731ZFYVE16chr5

79735851

-BDP1chr5

70848943

+
In-frameENST00000338008ENST00000380675ZFYVE16chr5

79735851

-BDP1chr5

70848943

+
In-frameENST00000505560ENST00000380675ZFYVE16chr5

79735851

-BDP1chr5

70848943

+
In-frameENST00000510158ENST00000380675ZFYVE16chr5

79735851

-BDP1chr5

70848943

+
intron-3CDSENST00000512442ENST00000358731ZFYVE16chr5

79735851

-BDP1chr5

70848943

+
intron-3CDSENST00000512442ENST00000380675ZFYVE16chr5

79735851

-BDP1chr5

70848943

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338008ZFYVE16chr579735851-ENST00000380675BDP1chr570848943+641625991592774871
ENST00000510158ZFYVE16chr579735851-ENST00000380675BDP1chr570848943+653327162762891871
ENST00000505560ZFYVE16chr579735851-ENST00000380675BDP1chr570848943+645726402002815871

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338008ENST00000380675ZFYVE16chr579735851-BDP1chr570848943+0.0001440540.9998559
ENST00000510158ENST00000380675ZFYVE16chr579735851-BDP1chr570848943+0.0001483810.9998516
ENST00000505560ENST00000380675ZFYVE16chr579735851-BDP1chr570848943+0.0001415390.9998585

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Fusion Genomic Features for ZFYVE16-BDP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZFYVE16-BDP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:79735851/chr5:70848943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BDP1

A6H8Y1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFYVE16chr5:79735851chr5:70848943ENST00000338008-418747_8058061540.0Zinc fingerFYVE-type
HgeneZFYVE16chr5:79735851chr5:70848943ENST00000505560-519747_8058061540.0Zinc fingerFYVE-type
HgeneZFYVE16chr5:79735851chr5:70848943ENST00000510158-519747_8058061540.0Zinc fingerFYVE-type
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381078_11034051360.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381223_12844051360.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238823_13274051360.6666666666667RegionNote=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381041_10944051360.6666666666667RepeatNote=5
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381095_11484051360.6666666666667RepeatNote=6
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381149_12034051360.6666666666667RepeatNote=7
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381204_12574051360.6666666666667RepeatNote=8%3B approximate
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381258_13274051360.6666666666667RepeatNote=9%3B approximate
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238823_8774051360.6666666666667RepeatNote=1%3B approximate
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238878_9324051360.6666666666667RepeatNote=2
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238933_9874051360.6666666666667RepeatNote=3
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238988_10404051360.6666666666667RepeatNote=4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391078_110323312625.0Coiled coilOntology_term=ECO:0000255
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391223_128423312625.0Coiled coilOntology_term=ECO:0000255
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339144_17723312625.0Coiled coilOntology_term=ECO:0000255
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238144_1774051360.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneBDP1chr5:79735851chr5:70848943ENST00000358731333984_11923312625.0Compositional biasNote=Ser-rich
TgeneBDP1chr5:79735851chr5:70848943ENST00000380675323884_1194051360.6666666666667Compositional biasNote=Ser-rich
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339295_34523312625.0DomainNote=Myb-like
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238295_3454051360.6666666666667DomainNote=Myb-like
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339355_47023312625.0RegionNote=Required for phosphorylation by CSNK2A1
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339823_132723312625.0RegionNote=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T
TgeneBDP1chr5:79735851chr5:70848943ENST000003806753238355_4704051360.6666666666667RegionNote=Required for phosphorylation by CSNK2A1
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391041_109423312625.0RepeatNote=5
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391095_114823312625.0RepeatNote=6
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391149_120323312625.0RepeatNote=7
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391204_125723312625.0RepeatNote=8%3B approximate
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391258_132723312625.0RepeatNote=9%3B approximate
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339823_87723312625.0RepeatNote=1%3B approximate
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339878_93223312625.0RepeatNote=2
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339933_98723312625.0RepeatNote=3
TgeneBDP1chr5:79735851chr5:70848943ENST000003587313339988_104023312625.0RepeatNote=4


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Fusion Gene Sequence for ZFYVE16-BDP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101151_101151_1_ZFYVE16-BDP1_ZFYVE16_chr5_79735851_ENST00000338008_BDP1_chr5_70848943_ENST00000380675_length(transcript)=6416nt_BP=2599nt
CTCTGCGCTGCCCGGTGGGGCGGGGAAAGAAGCCCTGAGCCGGGATCTGGCACTCCCAGGACTCCCGGCCGGGGTAGCTCTTCACTCCTC
AGCGCGACGTCGTGTCGAGTTCCCAAAAAGCTCCGCAGGGGCTGTAGGGAGGCATACAAGAATTAAATTCTGAATAAGTCTGCAGGTAGG
ATGGACAGTTATTTTAAAGCAGCTGTCAGTGACTTGGACAAACTCCTTGATGATTTTGAACAGAACCCAGATGAACAAGATTATCTCCAA
GATGTACAAAATGCATATGATTCTAACCACTGCTCAGTTTCTTCAGAGTTGGCTTCCTCACAGCGAACTTCATTGCTCCCAAAAGACCAA
GAGTGCGTTAATAGTTGTGCCTCATCAGAAACAAGCTATGGAACAAATGAGAGTTCCCTGAATGAAAAAACACTCAAGGGACTTACTTCT
ATACAAAATGAAAAAAATGTAACAGGACTTGATCTTCTTTCTTCTGTGGATGGTGGTACTTCAGATGAAATCCAGCCGTTATATATGGGA
CGATGTAGTAAACCTATCTGTGATCTGATAAGTGACATGGGTAACTTAGTTCATGCAACCAATAGTGAAGAAGATATTAAAAAATTATTG
CCAGATGATTTTAAGTCTAATGCAGATTCCTTGATTGGATTGGATTTATCTTCAGTGTCAGATACTCCCTGTGTTTCTTCAACAGACCAT
GATAGTGATACTGTCAGAGAACAACAGAATGATATCAGTTCTGAATTACAAAATAGAGAAATCGGAGGAATCAAAGAATTGGGTATAAAA
GTAGATACAACACTTTCAGATTCCTATAATTACAGTGGAACAGAAAATTTAAAAGATAAAAAGATCTTTAATCAGTTAGAATCAATTGTT
GATTTTAACATGTCATCTGCTTTGACTCGACAAAGTTCCAAAATGTTTCATGCCAAAGACAAGCTACAACACAAGAGCCAGCCATGTGGA
TTACTAAAAGATGTTGGCTTAGTAAAAGAGGAAGTAGATGTGGCAGTCATAACTGCCGCAGAATGTTTAAAAGAAGAGGGCAAGACAAGT
GCTTTGACCTGCAGCCTTCCGAAAAATGAAGATTTATGCTTAAATGATTCAAATTCAAGAGATGAAAATTTCAAATTACCTGACTTTTCC
TTTCAGGAAGATAAGACTGTTATAAAACAATCTGCACAAGAAGACTCAAAAAGTTTAGACCTTAAGGATAATGATGTAATCCAAGATTCC
TCTTCAGCTTTACATGTTTCCAGTAAAGATGTGCCGTCCTCATTGTCCTGTCTTCCTGCGTCTGGGTCTATGTGTGGATCATTAATTGAA
AGTAAAGCACGGGGTGATTTTTTACCTCAGCATGAACATAAAGATAATATACAAGATGCAGTGACTATACATGAAGAAATACAGAACAGT
GTTGTTCTAGGTGGGGAACCATTCAAAGAGAATGATCTTTTGAAACAGGAAAAATGTAAAAGCATACTCCTTCAGTCATTAATTGAAGGG
ATGGAAGACAGAAAGATAGATCCTGACCAGACAGTAATCAGAGCTGAGTCTTTGGATGGTGGTGACACCAGTTCTACAGTTGTAGAATCT
CAAGAGGGGCTTTCTGGCACTCATGTCCCAGAGTCTTCTGATTGTTGTGAAGGTTTTATTAATACTTTTTCAAGCAATGATATGGATGGG
CAAGACTTAGATTACTTTAATATTGATGAAGGCGCAAAAAGTGGCCCACTAATTAGTGATGCTGAACTTGATGCCTTTCTGACAGAACAG
TATCTTCAGACCACTAACATAAAGTCTTTTGAAGAAAATGTAAATGACTCTAAATCGCAAATGAATCAGATAGATATGAAAGGCTTAGAT
GATGGAAACATCAATAATATATATTTCAATGCAGAAGCAGGAGCTATTGGGGAAAGTCATGGTATTAATATAATTTGTGAAATAGTTGAT
AAACAAAATACAATAGAAAATGGCCTTTCTTTAGGAGAAAAAAGCACTATTCCAGTTCAACAAGGGTTACCTACCAGTAAGTCTGAGATT
ACAAATCAATTATCGGTCTCTGATATTAACAGTCAATCTGTTGGAGGGGCCAGACCTAAGCAATTGTTTAGCCTTCCATCAAGAACAAGG
AGTTCAAAGGACCTGAATAAGCCAGATGTTCCAGATACAATAGAAAGTGAACCCAGCACAGCAGATACCGTTGTTCCAATCACTTGTGCT
ATAGATTCTACAGCTGATCCACAGGTTAGCTTCAACTCTAATTACATTGATATAGAAAGTAATTCTGAAGGTGGATCTAGTTTCGTAACT
GCAAATGAAGATTCTGTACCTGAAAACACTTGCAAAGAAGGCTTGGTTTTGGGCCAGAAACAGCCTACTTGGGTTCCTGATTCAGAAGCT
CCAAACTGTATGAACTGCCAAGTCAAATTTACTTTTACCAAACGGCGACACCATTGCCGAGCATGTGGGAAAGTATTTTGTGGTGTCTGT
TGTAATAGGAAGTGTAAACTGCAATATCTAGAAAAGGAAGCAAGAGTATGTGTAGTCTGCTATGAAACTATTAGTAAAGTATTTGTTTAC
CAGCAACTTCAGTTGGTCAAGATGCCATGGGTTTATCTATTTCTGGAAGAGATAATTCTAAAAAGCCGCCTGATAATTTGGATCTTGTAT
CTAGGAAGAGATTTCAATGCAGGCTTGATAAAAATGACCACATTCCTCCTGCCAAAAAACGTTCACTCACTTTAAGAGATGACTGTCAAG
AATATACCACTGAGGTGCACTCAAAGGAATTAACAAATGTTTTTGAGGAAACAGGGGAGTCTCACAAGGGACAAGATATTTTTCTTACCT
CAGGAAGCACACTGACAACTCCAGAACCTCAAAGACAGCAAGTTGAAGCAGCTTTTCAGAGTAGAGGATCTAGATCTCCTGATGCATGCA
TGGACAAGAATGTGCCTCAGTTACCTCAGGATGAAATGATTGTGTCTGATAAGGAAGAAAGAACTGATGCTGCTCCTAAGTCTCAGCAAA
TGGATAGCAGAACATCGTCTTCTAAAGCCTCACTATCCAGACCTGGCAGAAGACCCCTGGGATTTTTATCTTTAATATGCTCAAAGAATA
GTTTGGAGTCTGATGAACCTATGCAAGTCCATAGTAAGAAACGCCTAAAACCTCTTATACCTGGATTAAGAAAGAAATTGAAAAGATCTA
ATCCATTCAATGAAAGCCAGGAAAAAAATCGAGAGTCCTCTGATCTGCTTCCATCTCCAAGTGTTATTACTACTCAATCTGAGAATATTA
GCAGCTCAGCAACTCAGGTTTCTTGTGATCAGCCCTTACTGAAAGAAGGATATAAAAGTGCCCAAAAGCGGGCCCCTCAAGGGGAGGCAA
CCACAGTCTCTGAATATTTCTTCAATGATATCTTCATTGAAGTGGATGAAACAGAATAAAACAATCTTTTCTCTTTTTCTTTTTTAAATT
AGGTCTAGGATTTCCAGAGTCAATTACATCAACAAAACAGTATTTAGAGCAAAATATCACTGTCTTATTTTTCTTTAGGTTGATTTTGAA
TACTTAATGAGCTTGATTTGAAGCTTTTATAATCAGTGGAAAACATTTCTGAGGTTCCTTTCATTCTGACTGATTCAGCATTTTGCAAAT
AGCAAGCAATTAAGACTGCTTTCTCAGACAGAAATAACAACTCTTGTTTACATTTTGACTCTTCCTGTGCTAAGCACACATGGACATTTG
GGAATGTTGTGGATATATGTCTCTGTATGAATTGCAGTGCAGACAGATTTGGGGGTTAATTGTATCATATTTAACATTTAGCAACTTCTT
TTGTGAAGATTTTTTATTTTTAGGGGGAGATGATGAAGGATGAAGGCTTTTTCATTTGCTTCTAAGTACAGTCATGTATCACATAATGAA
GTTTAAGTCAATGATGGACCACATATATTACAGTGGTCCCATGCAATTAAAATGGAGATAAATTCCTATCAACTAGTGACATTATAGCCA
TCATAACACAGTGCATTGCTTTTTTATGTTTAGATATGTTTAGATACACAAATACTTACTATTGTGTTACAACTGCCTACAGTATTCAGC
ATAGTAACACATTGTAGAGGTTTGTAGCCGAGGAGCAATAGGCTATACCACATAGCCTCAGTCTGTACGGTGTGTAGCAGCCTGTACCAT
CTCAGTGTTTGTAAGTACACTCTGCGTTGTTTCACACAAGATCACCTAACAAGGCAATTCTTAGAACATGTAGTTAAGGGACACGTGACT
ATATGTGAAAACAAATTGTCAAACTTCACTTTAGTATGGCAAATGTTAAAGAACTTTTCTATTATCAGCTGTTTGTCTGACTGAAAAATA
CATATTTTTCTAATTCATGGTGATGTAACATTAGTCCTAATTGAAAAACTAGTATTTAAACATAATTATTTATAAAGATGACACATCAAA
GGGCTTATTTATTTTTAAATTTTTTATTTAAAAGGATATTCAGTTTTAGCTATTTTTACCCCTCAGATTGTAGATAAAGAAGGCATTAAA
TTTATGTTTGTCTCCTTTTTCTGTTTAATTTTAAAGATATTTAAAATGATATAACTAAAAATGTTTAGCTGGTGTATATGTTTTGAATAC
CTTTTTCCCCTCAGTTTAGTATATTGACTTTGTACTGTAAATTTTTCTGCTTTTCTTGGATAATCTCAGGATTTTCATGAGGATAGGGGG
AACTCAACTTTATTTATGAGACAAAATTTCCATACAAAGCTCAATCTCCTTTATACACCCACAGACATAATATTAGTTTTTAAAAAGCCA
ATTTCTTCATAGTTTTTTCCCATTAAATTCTCAAGGAACACTTGGATCTTTAAGCACGGAACATAATCATGATGTTAAAAACAGAGAAAA
TAAGGCTTTATAAAGTTAATGATTATCATCAGTATGAATTTAAGGTTTGTTTTAATTTCAAGATTTGATTTTTTATACGTGTAATTCTAT
TATCTACCCAAGCAGATCTGTAGTGGTTCCAATTAGACTTCTCAAACAGCAAATTTATCCTGATTTTATTTGAAAAGCCTCTTGGATTGA
TAGTATAGTAGCTCAGGCATTGGAAACTTTCTGCAAACTGTTTTGGGTTTGCAGGCCAGATGGTCTCTGTGGCAGCTACTCAGCTCTGCA
ATTTCAGTGTGAAAGAAGCCATAGACAGTACTTGAATGAAGGACTGTGGCTGGATTGGCCTTTTAGTTTGACCCCCTACATTAGGCCCCA
AATTTTCTTACCCTGAGGTGCTGATATCTGTATGGATGAGTTATTTGTCACTAAAGTTATGAGTTGTGCCTAAAAGTTAAAACTGTTGAC
TGTATTATGTAATGATCAGTATTTCAGTTGGGAAGATATTTTAGAGTCTAGATAATTATGTTTGTATATTGAAAAAATGGTGGCCAGTTT
TTAAGTTCCTTAATAGAAGAGAATTATGTCTCAGCACATATAACAGTAATGCTAATTTATTGAAACTACTGCTGTTAGAGCACTTCTTAT
TCATTGTCTTTTAGTGAAATTTATGGCGTAACACTTTGTCAGAGAGGAGGCTATATAATTCGGAGCGGAAATTGTCTATAAGTAGGCATT
TATTTCATGATTGATATGTCACAGAAATCATGGTAGTAAATCACATTGCTATTTGAATACCCTGTTTTTGTAAGTTTTTAAAACTCATAT
TCTGAAAAGATTTCATTCTCTTAGTGTTAGCTTGGGAGTTAGATTGCCATGATTAAACTATTATTTATCCTTGTGTAATATTAGTTTTTA
ACTTTAACATCTGTTTCTTTTTAATCTATAATGAGCTAGTTTTATGGAAAATGGAATTTCTTACTATATAAAGAATACAGAGACTCATTG
TATTAGAGAATCAAGTCAGCCAGCTAAAGTATCCTACTGTTAAATCCTTAAACCTAATTTTGGAAAAGAGAAAGTTAATCAATGTATTTA
CCTTACATGTTGGAAAGAACTATGTTAGGTCTGATTCATGTGAAGAAGATGTTGCAAAGGATTTATTTCACAAATTTTAAAGGAGATATG
AGTAAAAGTTTTTATCTTTTCTTGACTTTTTCTCCTGAACACTTATGTCTTAGCAAGTGGTCAACATGAGGATTTGAACGCCTAATTGTT
GGTAAATGGTTGAGGCATGACAAAAATATTAATATCCACTGTTTACCATCATGTTATTTGAAACAAAAGTGACCATGTATACTATCTTGC
TTGAAGAAGTCTTTGACAGAAAAAGCAATATCATGTCATTTATAAATTTTCTTGTTCTAAAGAAAGCAGTTATATATATATATAAATTAT

>101151_101151_1_ZFYVE16-BDP1_ZFYVE16_chr5_79735851_ENST00000338008_BDP1_chr5_70848943_ENST00000380675_length(amino acids)=871AA_BP=813
MNKSAGRMDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQECVNSCASSETSYGTNESSLNEK
TLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTP
CVSSTDHDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESIVDFNMSSALTRQSSKMFHAKDKLQ
HKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEGKTSALTCSLPKNEDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLDLKD
NDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHEEIQNSVVLGGEPFKENDLLKQEKCKSIL
LQSLIEGMEDRKIDPDQTVIRAESLDGGDTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAEL
DAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGL
PTSKSEITNQLSVSDINSQSVGGARPKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSE
GGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYET

--------------------------------------------------------------
>101151_101151_2_ZFYVE16-BDP1_ZFYVE16_chr5_79735851_ENST00000505560_BDP1_chr5_70848943_ENST00000380675_length(transcript)=6457nt_BP=2640nt
GGTGGGGCGGGGAAAGAAGCCCTGAGCCGGGATCTGGCACTCCCAGGACTCCCGGCCGGGGTAGCTCTTCACTCCTCAGCGCGACGTCGT
GTCGAGTTCCCAAAAAGCTCCGCAGGGGCTGTAGGGAGATTCCTGTGAGGTTTCTCGGGCTTATTTGGTGGAGTTTCTGTTCCAGACCAG
AGGCATACAAGAATTAAATTCTGAATAAGTCTGCAGGTAGGATGGACAGTTATTTTAAAGCAGCTGTCAGTGACTTGGACAAACTCCTTG
ATGATTTTGAACAGAACCCAGATGAACAAGATTATCTCCAAGATGTACAAAATGCATATGATTCTAACCACTGCTCAGTTTCTTCAGAGT
TGGCTTCCTCACAGCGAACTTCATTGCTCCCAAAAGACCAAGAGTGCGTTAATAGTTGTGCCTCATCAGAAACAAGCTATGGAACAAATG
AGAGTTCCCTGAATGAAAAAACACTCAAGGGACTTACTTCTATACAAAATGAAAAAAATGTAACAGGACTTGATCTTCTTTCTTCTGTGG
ATGGTGGTACTTCAGATGAAATCCAGCCGTTATATATGGGACGATGTAGTAAACCTATCTGTGATCTGATAAGTGACATGGGTAACTTAG
TTCATGCAACCAATAGTGAAGAAGATATTAAAAAATTATTGCCAGATGATTTTAAGTCTAATGCAGATTCCTTGATTGGATTGGATTTAT
CTTCAGTGTCAGATACTCCCTGTGTTTCTTCAACAGACCATGATAGTGATACTGTCAGAGAACAACAGAATGATATCAGTTCTGAATTAC
AAAATAGAGAAATCGGAGGAATCAAAGAATTGGGTATAAAAGTAGATACAACACTTTCAGATTCCTATAATTACAGTGGAACAGAAAATT
TAAAAGATAAAAAGATCTTTAATCAGTTAGAATCAATTGTTGATTTTAACATGTCATCTGCTTTGACTCGACAAAGTTCCAAAATGTTTC
ATGCCAAAGACAAGCTACAACACAAGAGCCAGCCATGTGGATTACTAAAAGATGTTGGCTTAGTAAAAGAGGAAGTAGATGTGGCAGTCA
TAACTGCCGCAGAATGTTTAAAAGAAGAGGGCAAGACAAGTGCTTTGACCTGCAGCCTTCCGAAAAATGAAGATTTATGCTTAAATGATT
CAAATTCAAGAGATGAAAATTTCAAATTACCTGACTTTTCCTTTCAGGAAGATAAGACTGTTATAAAACAATCTGCACAAGAAGACTCAA
AAAGTTTAGACCTTAAGGATAATGATGTAATCCAAGATTCCTCTTCAGCTTTACATGTTTCCAGTAAAGATGTGCCGTCCTCATTGTCCT
GTCTTCCTGCGTCTGGGTCTATGTGTGGATCATTAATTGAAAGTAAAGCACGGGGTGATTTTTTACCTCAGCATGAACATAAAGATAATA
TACAAGATGCAGTGACTATACATGAAGAAATACAGAACAGTGTTGTTCTAGGTGGGGAACCATTCAAAGAGAATGATCTTTTGAAACAGG
AAAAATGTAAAAGCATACTCCTTCAGTCATTAATTGAAGGGATGGAAGACAGAAAGATAGATCCTGACCAGACAGTAATCAGAGCTGAGT
CTTTGGATGGTGGTGACACCAGTTCTACAGTTGTAGAATCTCAAGAGGGGCTTTCTGGCACTCATGTCCCAGAGTCTTCTGATTGTTGTG
AAGGTTTTATTAATACTTTTTCAAGCAATGATATGGATGGGCAAGACTTAGATTACTTTAATATTGATGAAGGCGCAAAAAGTGGCCCAC
TAATTAGTGATGCTGAACTTGATGCCTTTCTGACAGAACAGTATCTTCAGACCACTAACATAAAGTCTTTTGAAGAAAATGTAAATGACT
CTAAATCGCAAATGAATCAGATAGATATGAAAGGCTTAGATGATGGAAACATCAATAATATATATTTCAATGCAGAAGCAGGAGCTATTG
GGGAAAGTCATGGTATTAATATAATTTGTGAAATAGTTGATAAACAAAATACAATAGAAAATGGCCTTTCTTTAGGAGAAAAAAGCACTA
TTCCAGTTCAACAAGGGTTACCTACCAGTAAGTCTGAGATTACAAATCAATTATCGGTCTCTGATATTAACAGTCAATCTGTTGGAGGGG
CCAGACCTAAGCAATTGTTTAGCCTTCCATCAAGAACAAGGAGTTCAAAGGACCTGAATAAGCCAGATGTTCCAGATACAATAGAAAGTG
AACCCAGCACAGCAGATACCGTTGTTCCAATCACTTGTGCTATAGATTCTACAGCTGATCCACAGGTTAGCTTCAACTCTAATTACATTG
ATATAGAAAGTAATTCTGAAGGTGGATCTAGTTTCGTAACTGCAAATGAAGATTCTGTACCTGAAAACACTTGCAAAGAAGGCTTGGTTT
TGGGCCAGAAACAGCCTACTTGGGTTCCTGATTCAGAAGCTCCAAACTGTATGAACTGCCAAGTCAAATTTACTTTTACCAAACGGCGAC
ACCATTGCCGAGCATGTGGGAAAGTATTTTGTGGTGTCTGTTGTAATAGGAAGTGTAAACTGCAATATCTAGAAAAGGAAGCAAGAGTAT
GTGTAGTCTGCTATGAAACTATTAGTAAAGTATTTGTTTACCAGCAACTTCAGTTGGTCAAGATGCCATGGGTTTATCTATTTCTGGAAG
AGATAATTCTAAAAAGCCGCCTGATAATTTGGATCTTGTATCTAGGAAGAGATTTCAATGCAGGCTTGATAAAAATGACCACATTCCTCC
TGCCAAAAAACGTTCACTCACTTTAAGAGATGACTGTCAAGAATATACCACTGAGGTGCACTCAAAGGAATTAACAAATGTTTTTGAGGA
AACAGGGGAGTCTCACAAGGGACAAGATATTTTTCTTACCTCAGGAAGCACACTGACAACTCCAGAACCTCAAAGACAGCAAGTTGAAGC
AGCTTTTCAGAGTAGAGGATCTAGATCTCCTGATGCATGCATGGACAAGAATGTGCCTCAGTTACCTCAGGATGAAATGATTGTGTCTGA
TAAGGAAGAAAGAACTGATGCTGCTCCTAAGTCTCAGCAAATGGATAGCAGAACATCGTCTTCTAAAGCCTCACTATCCAGACCTGGCAG
AAGACCCCTGGGATTTTTATCTTTAATATGCTCAAAGAATAGTTTGGAGTCTGATGAACCTATGCAAGTCCATAGTAAGAAACGCCTAAA
ACCTCTTATACCTGGATTAAGAAAGAAATTGAAAAGATCTAATCCATTCAATGAAAGCCAGGAAAAAAATCGAGAGTCCTCTGATCTGCT
TCCATCTCCAAGTGTTATTACTACTCAATCTGAGAATATTAGCAGCTCAGCAACTCAGGTTTCTTGTGATCAGCCCTTACTGAAAGAAGG
ATATAAAAGTGCCCAAAAGCGGGCCCCTCAAGGGGAGGCAACCACAGTCTCTGAATATTTCTTCAATGATATCTTCATTGAAGTGGATGA
AACAGAATAAAACAATCTTTTCTCTTTTTCTTTTTTAAATTAGGTCTAGGATTTCCAGAGTCAATTACATCAACAAAACAGTATTTAGAG
CAAAATATCACTGTCTTATTTTTCTTTAGGTTGATTTTGAATACTTAATGAGCTTGATTTGAAGCTTTTATAATCAGTGGAAAACATTTC
TGAGGTTCCTTTCATTCTGACTGATTCAGCATTTTGCAAATAGCAAGCAATTAAGACTGCTTTCTCAGACAGAAATAACAACTCTTGTTT
ACATTTTGACTCTTCCTGTGCTAAGCACACATGGACATTTGGGAATGTTGTGGATATATGTCTCTGTATGAATTGCAGTGCAGACAGATT
TGGGGGTTAATTGTATCATATTTAACATTTAGCAACTTCTTTTGTGAAGATTTTTTATTTTTAGGGGGAGATGATGAAGGATGAAGGCTT
TTTCATTTGCTTCTAAGTACAGTCATGTATCACATAATGAAGTTTAAGTCAATGATGGACCACATATATTACAGTGGTCCCATGCAATTA
AAATGGAGATAAATTCCTATCAACTAGTGACATTATAGCCATCATAACACAGTGCATTGCTTTTTTATGTTTAGATATGTTTAGATACAC
AAATACTTACTATTGTGTTACAACTGCCTACAGTATTCAGCATAGTAACACATTGTAGAGGTTTGTAGCCGAGGAGCAATAGGCTATACC
ACATAGCCTCAGTCTGTACGGTGTGTAGCAGCCTGTACCATCTCAGTGTTTGTAAGTACACTCTGCGTTGTTTCACACAAGATCACCTAA
CAAGGCAATTCTTAGAACATGTAGTTAAGGGACACGTGACTATATGTGAAAACAAATTGTCAAACTTCACTTTAGTATGGCAAATGTTAA
AGAACTTTTCTATTATCAGCTGTTTGTCTGACTGAAAAATACATATTTTTCTAATTCATGGTGATGTAACATTAGTCCTAATTGAAAAAC
TAGTATTTAAACATAATTATTTATAAAGATGACACATCAAAGGGCTTATTTATTTTTAAATTTTTTATTTAAAAGGATATTCAGTTTTAG
CTATTTTTACCCCTCAGATTGTAGATAAAGAAGGCATTAAATTTATGTTTGTCTCCTTTTTCTGTTTAATTTTAAAGATATTTAAAATGA
TATAACTAAAAATGTTTAGCTGGTGTATATGTTTTGAATACCTTTTTCCCCTCAGTTTAGTATATTGACTTTGTACTGTAAATTTTTCTG
CTTTTCTTGGATAATCTCAGGATTTTCATGAGGATAGGGGGAACTCAACTTTATTTATGAGACAAAATTTCCATACAAAGCTCAATCTCC
TTTATACACCCACAGACATAATATTAGTTTTTAAAAAGCCAATTTCTTCATAGTTTTTTCCCATTAAATTCTCAAGGAACACTTGGATCT
TTAAGCACGGAACATAATCATGATGTTAAAAACAGAGAAAATAAGGCTTTATAAAGTTAATGATTATCATCAGTATGAATTTAAGGTTTG
TTTTAATTTCAAGATTTGATTTTTTATACGTGTAATTCTATTATCTACCCAAGCAGATCTGTAGTGGTTCCAATTAGACTTCTCAAACAG
CAAATTTATCCTGATTTTATTTGAAAAGCCTCTTGGATTGATAGTATAGTAGCTCAGGCATTGGAAACTTTCTGCAAACTGTTTTGGGTT
TGCAGGCCAGATGGTCTCTGTGGCAGCTACTCAGCTCTGCAATTTCAGTGTGAAAGAAGCCATAGACAGTACTTGAATGAAGGACTGTGG
CTGGATTGGCCTTTTAGTTTGACCCCCTACATTAGGCCCCAAATTTTCTTACCCTGAGGTGCTGATATCTGTATGGATGAGTTATTTGTC
ACTAAAGTTATGAGTTGTGCCTAAAAGTTAAAACTGTTGACTGTATTATGTAATGATCAGTATTTCAGTTGGGAAGATATTTTAGAGTCT
AGATAATTATGTTTGTATATTGAAAAAATGGTGGCCAGTTTTTAAGTTCCTTAATAGAAGAGAATTATGTCTCAGCACATATAACAGTAA
TGCTAATTTATTGAAACTACTGCTGTTAGAGCACTTCTTATTCATTGTCTTTTAGTGAAATTTATGGCGTAACACTTTGTCAGAGAGGAG
GCTATATAATTCGGAGCGGAAATTGTCTATAAGTAGGCATTTATTTCATGATTGATATGTCACAGAAATCATGGTAGTAAATCACATTGC
TATTTGAATACCCTGTTTTTGTAAGTTTTTAAAACTCATATTCTGAAAAGATTTCATTCTCTTAGTGTTAGCTTGGGAGTTAGATTGCCA
TGATTAAACTATTATTTATCCTTGTGTAATATTAGTTTTTAACTTTAACATCTGTTTCTTTTTAATCTATAATGAGCTAGTTTTATGGAA
AATGGAATTTCTTACTATATAAAGAATACAGAGACTCATTGTATTAGAGAATCAAGTCAGCCAGCTAAAGTATCCTACTGTTAAATCCTT
AAACCTAATTTTGGAAAAGAGAAAGTTAATCAATGTATTTACCTTACATGTTGGAAAGAACTATGTTAGGTCTGATTCATGTGAAGAAGA
TGTTGCAAAGGATTTATTTCACAAATTTTAAAGGAGATATGAGTAAAAGTTTTTATCTTTTCTTGACTTTTTCTCCTGAACACTTATGTC
TTAGCAAGTGGTCAACATGAGGATTTGAACGCCTAATTGTTGGTAAATGGTTGAGGCATGACAAAAATATTAATATCCACTGTTTACCAT
CATGTTATTTGAAACAAAAGTGACCATGTATACTATCTTGCTTGAAGAAGTCTTTGACAGAAAAAGCAATATCATGTCATTTATAAATTT

>101151_101151_2_ZFYVE16-BDP1_ZFYVE16_chr5_79735851_ENST00000505560_BDP1_chr5_70848943_ENST00000380675_length(amino acids)=871AA_BP=813
MNKSAGRMDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQECVNSCASSETSYGTNESSLNEK
TLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTP
CVSSTDHDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESIVDFNMSSALTRQSSKMFHAKDKLQ
HKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEGKTSALTCSLPKNEDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLDLKD
NDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHEEIQNSVVLGGEPFKENDLLKQEKCKSIL
LQSLIEGMEDRKIDPDQTVIRAESLDGGDTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAEL
DAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGL
PTSKSEITNQLSVSDINSQSVGGARPKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSE
GGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYET

--------------------------------------------------------------
>101151_101151_3_ZFYVE16-BDP1_ZFYVE16_chr5_79735851_ENST00000510158_BDP1_chr5_70848943_ENST00000380675_length(transcript)=6533nt_BP=2716nt
CCGGTGGGGCGGGGAAAGAAGCCCTGAGCCGGGATCTGGCACTCCCAGGACTCCCGGCCGGGGTAGCTCTTCACTCCTCAGCGCGACGTC
GTGTCGAGTTCCCAAAAAGCTCCGCAGGGGCTGTAGGGAGGTGATCTCATCCATTAACAGCTGTGTGTTGCCAGTTCCCAAATCTTTATC
TATCTCAGACTTCTCTCCTGCATTCCAGATTCTTATATTCAGCTGCCTTTTGGATATCTCTCCCAGGATGTTCTCAAGGCATACAAGAAT
TAAATTCTGAATAAGTCTGCAGGTAGGATGGACAGTTATTTTAAAGCAGCTGTCAGTGACTTGGACAAACTCCTTGATGATTTTGAACAG
AACCCAGATGAACAAGATTATCTCCAAGATGTACAAAATGCATATGATTCTAACCACTGCTCAGTTTCTTCAGAGTTGGCTTCCTCACAG
CGAACTTCATTGCTCCCAAAAGACCAAGAGTGCGTTAATAGTTGTGCCTCATCAGAAACAAGCTATGGAACAAATGAGAGTTCCCTGAAT
GAAAAAACACTCAAGGGACTTACTTCTATACAAAATGAAAAAAATGTAACAGGACTTGATCTTCTTTCTTCTGTGGATGGTGGTACTTCA
GATGAAATCCAGCCGTTATATATGGGACGATGTAGTAAACCTATCTGTGATCTGATAAGTGACATGGGTAACTTAGTTCATGCAACCAAT
AGTGAAGAAGATATTAAAAAATTATTGCCAGATGATTTTAAGTCTAATGCAGATTCCTTGATTGGATTGGATTTATCTTCAGTGTCAGAT
ACTCCCTGTGTTTCTTCAACAGACCATGATAGTGATACTGTCAGAGAACAACAGAATGATATCAGTTCTGAATTACAAAATAGAGAAATC
GGAGGAATCAAAGAATTGGGTATAAAAGTAGATACAACACTTTCAGATTCCTATAATTACAGTGGAACAGAAAATTTAAAAGATAAAAAG
ATCTTTAATCAGTTAGAATCAATTGTTGATTTTAACATGTCATCTGCTTTGACTCGACAAAGTTCCAAAATGTTTCATGCCAAAGACAAG
CTACAACACAAGAGCCAGCCATGTGGATTACTAAAAGATGTTGGCTTAGTAAAAGAGGAAGTAGATGTGGCAGTCATAACTGCCGCAGAA
TGTTTAAAAGAAGAGGGCAAGACAAGTGCTTTGACCTGCAGCCTTCCGAAAAATGAAGATTTATGCTTAAATGATTCAAATTCAAGAGAT
GAAAATTTCAAATTACCTGACTTTTCCTTTCAGGAAGATAAGACTGTTATAAAACAATCTGCACAAGAAGACTCAAAAAGTTTAGACCTT
AAGGATAATGATGTAATCCAAGATTCCTCTTCAGCTTTACATGTTTCCAGTAAAGATGTGCCGTCCTCATTGTCCTGTCTTCCTGCGTCT
GGGTCTATGTGTGGATCATTAATTGAAAGTAAAGCACGGGGTGATTTTTTACCTCAGCATGAACATAAAGATAATATACAAGATGCAGTG
ACTATACATGAAGAAATACAGAACAGTGTTGTTCTAGGTGGGGAACCATTCAAAGAGAATGATCTTTTGAAACAGGAAAAATGTAAAAGC
ATACTCCTTCAGTCATTAATTGAAGGGATGGAAGACAGAAAGATAGATCCTGACCAGACAGTAATCAGAGCTGAGTCTTTGGATGGTGGT
GACACCAGTTCTACAGTTGTAGAATCTCAAGAGGGGCTTTCTGGCACTCATGTCCCAGAGTCTTCTGATTGTTGTGAAGGTTTTATTAAT
ACTTTTTCAAGCAATGATATGGATGGGCAAGACTTAGATTACTTTAATATTGATGAAGGCGCAAAAAGTGGCCCACTAATTAGTGATGCT
GAACTTGATGCCTTTCTGACAGAACAGTATCTTCAGACCACTAACATAAAGTCTTTTGAAGAAAATGTAAATGACTCTAAATCGCAAATG
AATCAGATAGATATGAAAGGCTTAGATGATGGAAACATCAATAATATATATTTCAATGCAGAAGCAGGAGCTATTGGGGAAAGTCATGGT
ATTAATATAATTTGTGAAATAGTTGATAAACAAAATACAATAGAAAATGGCCTTTCTTTAGGAGAAAAAAGCACTATTCCAGTTCAACAA
GGGTTACCTACCAGTAAGTCTGAGATTACAAATCAATTATCGGTCTCTGATATTAACAGTCAATCTGTTGGAGGGGCCAGACCTAAGCAA
TTGTTTAGCCTTCCATCAAGAACAAGGAGTTCAAAGGACCTGAATAAGCCAGATGTTCCAGATACAATAGAAAGTGAACCCAGCACAGCA
GATACCGTTGTTCCAATCACTTGTGCTATAGATTCTACAGCTGATCCACAGGTTAGCTTCAACTCTAATTACATTGATATAGAAAGTAAT
TCTGAAGGTGGATCTAGTTTCGTAACTGCAAATGAAGATTCTGTACCTGAAAACACTTGCAAAGAAGGCTTGGTTTTGGGCCAGAAACAG
CCTACTTGGGTTCCTGATTCAGAAGCTCCAAACTGTATGAACTGCCAAGTCAAATTTACTTTTACCAAACGGCGACACCATTGCCGAGCA
TGTGGGAAAGTATTTTGTGGTGTCTGTTGTAATAGGAAGTGTAAACTGCAATATCTAGAAAAGGAAGCAAGAGTATGTGTAGTCTGCTAT
GAAACTATTAGTAAAGTATTTGTTTACCAGCAACTTCAGTTGGTCAAGATGCCATGGGTTTATCTATTTCTGGAAGAGATAATTCTAAAA
AGCCGCCTGATAATTTGGATCTTGTATCTAGGAAGAGATTTCAATGCAGGCTTGATAAAAATGACCACATTCCTCCTGCCAAAAAACGTT
CACTCACTTTAAGAGATGACTGTCAAGAATATACCACTGAGGTGCACTCAAAGGAATTAACAAATGTTTTTGAGGAAACAGGGGAGTCTC
ACAAGGGACAAGATATTTTTCTTACCTCAGGAAGCACACTGACAACTCCAGAACCTCAAAGACAGCAAGTTGAAGCAGCTTTTCAGAGTA
GAGGATCTAGATCTCCTGATGCATGCATGGACAAGAATGTGCCTCAGTTACCTCAGGATGAAATGATTGTGTCTGATAAGGAAGAAAGAA
CTGATGCTGCTCCTAAGTCTCAGCAAATGGATAGCAGAACATCGTCTTCTAAAGCCTCACTATCCAGACCTGGCAGAAGACCCCTGGGAT
TTTTATCTTTAATATGCTCAAAGAATAGTTTGGAGTCTGATGAACCTATGCAAGTCCATAGTAAGAAACGCCTAAAACCTCTTATACCTG
GATTAAGAAAGAAATTGAAAAGATCTAATCCATTCAATGAAAGCCAGGAAAAAAATCGAGAGTCCTCTGATCTGCTTCCATCTCCAAGTG
TTATTACTACTCAATCTGAGAATATTAGCAGCTCAGCAACTCAGGTTTCTTGTGATCAGCCCTTACTGAAAGAAGGATATAAAAGTGCCC
AAAAGCGGGCCCCTCAAGGGGAGGCAACCACAGTCTCTGAATATTTCTTCAATGATATCTTCATTGAAGTGGATGAAACAGAATAAAACA
ATCTTTTCTCTTTTTCTTTTTTAAATTAGGTCTAGGATTTCCAGAGTCAATTACATCAACAAAACAGTATTTAGAGCAAAATATCACTGT
CTTATTTTTCTTTAGGTTGATTTTGAATACTTAATGAGCTTGATTTGAAGCTTTTATAATCAGTGGAAAACATTTCTGAGGTTCCTTTCA
TTCTGACTGATTCAGCATTTTGCAAATAGCAAGCAATTAAGACTGCTTTCTCAGACAGAAATAACAACTCTTGTTTACATTTTGACTCTT
CCTGTGCTAAGCACACATGGACATTTGGGAATGTTGTGGATATATGTCTCTGTATGAATTGCAGTGCAGACAGATTTGGGGGTTAATTGT
ATCATATTTAACATTTAGCAACTTCTTTTGTGAAGATTTTTTATTTTTAGGGGGAGATGATGAAGGATGAAGGCTTTTTCATTTGCTTCT
AAGTACAGTCATGTATCACATAATGAAGTTTAAGTCAATGATGGACCACATATATTACAGTGGTCCCATGCAATTAAAATGGAGATAAAT
TCCTATCAACTAGTGACATTATAGCCATCATAACACAGTGCATTGCTTTTTTATGTTTAGATATGTTTAGATACACAAATACTTACTATT
GTGTTACAACTGCCTACAGTATTCAGCATAGTAACACATTGTAGAGGTTTGTAGCCGAGGAGCAATAGGCTATACCACATAGCCTCAGTC
TGTACGGTGTGTAGCAGCCTGTACCATCTCAGTGTTTGTAAGTACACTCTGCGTTGTTTCACACAAGATCACCTAACAAGGCAATTCTTA
GAACATGTAGTTAAGGGACACGTGACTATATGTGAAAACAAATTGTCAAACTTCACTTTAGTATGGCAAATGTTAAAGAACTTTTCTATT
ATCAGCTGTTTGTCTGACTGAAAAATACATATTTTTCTAATTCATGGTGATGTAACATTAGTCCTAATTGAAAAACTAGTATTTAAACAT
AATTATTTATAAAGATGACACATCAAAGGGCTTATTTATTTTTAAATTTTTTATTTAAAAGGATATTCAGTTTTAGCTATTTTTACCCCT
CAGATTGTAGATAAAGAAGGCATTAAATTTATGTTTGTCTCCTTTTTCTGTTTAATTTTAAAGATATTTAAAATGATATAACTAAAAATG
TTTAGCTGGTGTATATGTTTTGAATACCTTTTTCCCCTCAGTTTAGTATATTGACTTTGTACTGTAAATTTTTCTGCTTTTCTTGGATAA
TCTCAGGATTTTCATGAGGATAGGGGGAACTCAACTTTATTTATGAGACAAAATTTCCATACAAAGCTCAATCTCCTTTATACACCCACA
GACATAATATTAGTTTTTAAAAAGCCAATTTCTTCATAGTTTTTTCCCATTAAATTCTCAAGGAACACTTGGATCTTTAAGCACGGAACA
TAATCATGATGTTAAAAACAGAGAAAATAAGGCTTTATAAAGTTAATGATTATCATCAGTATGAATTTAAGGTTTGTTTTAATTTCAAGA
TTTGATTTTTTATACGTGTAATTCTATTATCTACCCAAGCAGATCTGTAGTGGTTCCAATTAGACTTCTCAAACAGCAAATTTATCCTGA
TTTTATTTGAAAAGCCTCTTGGATTGATAGTATAGTAGCTCAGGCATTGGAAACTTTCTGCAAACTGTTTTGGGTTTGCAGGCCAGATGG
TCTCTGTGGCAGCTACTCAGCTCTGCAATTTCAGTGTGAAAGAAGCCATAGACAGTACTTGAATGAAGGACTGTGGCTGGATTGGCCTTT
TAGTTTGACCCCCTACATTAGGCCCCAAATTTTCTTACCCTGAGGTGCTGATATCTGTATGGATGAGTTATTTGTCACTAAAGTTATGAG
TTGTGCCTAAAAGTTAAAACTGTTGACTGTATTATGTAATGATCAGTATTTCAGTTGGGAAGATATTTTAGAGTCTAGATAATTATGTTT
GTATATTGAAAAAATGGTGGCCAGTTTTTAAGTTCCTTAATAGAAGAGAATTATGTCTCAGCACATATAACAGTAATGCTAATTTATTGA
AACTACTGCTGTTAGAGCACTTCTTATTCATTGTCTTTTAGTGAAATTTATGGCGTAACACTTTGTCAGAGAGGAGGCTATATAATTCGG
AGCGGAAATTGTCTATAAGTAGGCATTTATTTCATGATTGATATGTCACAGAAATCATGGTAGTAAATCACATTGCTATTTGAATACCCT
GTTTTTGTAAGTTTTTAAAACTCATATTCTGAAAAGATTTCATTCTCTTAGTGTTAGCTTGGGAGTTAGATTGCCATGATTAAACTATTA
TTTATCCTTGTGTAATATTAGTTTTTAACTTTAACATCTGTTTCTTTTTAATCTATAATGAGCTAGTTTTATGGAAAATGGAATTTCTTA
CTATATAAAGAATACAGAGACTCATTGTATTAGAGAATCAAGTCAGCCAGCTAAAGTATCCTACTGTTAAATCCTTAAACCTAATTTTGG
AAAAGAGAAAGTTAATCAATGTATTTACCTTACATGTTGGAAAGAACTATGTTAGGTCTGATTCATGTGAAGAAGATGTTGCAAAGGATT
TATTTCACAAATTTTAAAGGAGATATGAGTAAAAGTTTTTATCTTTTCTTGACTTTTTCTCCTGAACACTTATGTCTTAGCAAGTGGTCA
ACATGAGGATTTGAACGCCTAATTGTTGGTAAATGGTTGAGGCATGACAAAAATATTAATATCCACTGTTTACCATCATGTTATTTGAAA
CAAAAGTGACCATGTATACTATCTTGCTTGAAGAAGTCTTTGACAGAAAAAGCAATATCATGTCATTTATAAATTTTCTTGTTCTAAAGA

>101151_101151_3_ZFYVE16-BDP1_ZFYVE16_chr5_79735851_ENST00000510158_BDP1_chr5_70848943_ENST00000380675_length(amino acids)=871AA_BP=813
MNKSAGRMDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQECVNSCASSETSYGTNESSLNEK
TLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTP
CVSSTDHDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESIVDFNMSSALTRQSSKMFHAKDKLQ
HKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEGKTSALTCSLPKNEDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLDLKD
NDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHEEIQNSVVLGGEPFKENDLLKQEKCKSIL
LQSLIEGMEDRKIDPDQTVIRAESLDGGDTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAEL
DAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGL
PTSKSEITNQLSVSDINSQSVGGARPKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSE
GGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYET

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZFYVE16-BDP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneBDP1chr5:79735851chr5:70848943ENST0000035873133391_2992331.66666666666652625.0ZBTB43
TgeneBDP1chr5:79735851chr5:70848943ENST0000038067532381_299405.33333333333331360.6666666666667ZBTB43


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFYVE16-BDP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZFYVE16-BDP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource