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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZFYVE9-BTF3L4 (FusionGDB2 ID:101187)

Fusion Gene Summary for ZFYVE9-BTF3L4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFYVE9-BTF3L4
Fusion gene ID: 101187
HgeneTgene
Gene symbol

ZFYVE9

BTF3L4

Gene ID

9372

91408

Gene namezinc finger FYVE-type containing 9basic transcription factor 3 like 4
SynonymsMADHIP|NSP|PPP1R173|SARA|SMADIP-
Cytomap

1p32.3

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger FYVE domain-containing protein 9MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchorMADH-interacting proteinnovel serine proteaseprotein phosphatase 1, regulatory subunit 173smad anchor for receptortranscription factor BTF3 homolog 4
Modification date2020031320200313
UniProtAcc.

Q96K17

Ensembl transtripts involved in fusion geneENST00000287727, ENST00000357206, 
ENST00000371591, ENST00000469134, 
ENST00000533836, ENST00000472944, 
ENST00000484036, ENST00000489308, 
ENST00000313334, 
Fusion gene scores* DoF score7 X 7 X 4=1967 X 8 X 4=224
# samples 78
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFYVE9 [Title/Abstract] AND BTF3L4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFYVE9(52608075)-BTF3L4(52530497), # samples:1
ZFYVE9(52705267)-BTF3L4(52549012), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZFYVE9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BTF3L4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-EI-6506-01AZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
ChimerDB4STADTCGA-VQ-A922-01AZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+


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Fusion Gene ORF analysis for ZFYVE9-BTF3L4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000287727ENST00000533836ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-3UTRENST00000357206ENST00000533836ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-3UTRENST00000371591ENST00000533836ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-5UTRENST00000287727ENST00000472944ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-5UTRENST00000287727ENST00000484036ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-5UTRENST00000357206ENST00000472944ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-5UTRENST00000357206ENST00000484036ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-5UTRENST00000371591ENST00000472944ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-5UTRENST00000371591ENST00000484036ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-intronENST00000287727ENST00000489308ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-intronENST00000357206ENST00000489308ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5CDS-intronENST00000371591ENST00000489308ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
5UTR-3CDSENST00000287727ENST00000313334ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-3CDSENST00000287727ENST00000489308ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-3CDSENST00000357206ENST00000313334ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-3CDSENST00000357206ENST00000489308ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-3UTRENST00000287727ENST00000533836ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-3UTRENST00000357206ENST00000533836ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-5UTRENST00000287727ENST00000472944ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-5UTRENST00000287727ENST00000484036ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-5UTRENST00000357206ENST00000472944ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
5UTR-5UTRENST00000357206ENST00000484036ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
In-frameENST00000287727ENST00000313334ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
In-frameENST00000357206ENST00000313334ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
In-frameENST00000371591ENST00000313334ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
intron-3CDSENST00000371591ENST00000313334ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-3CDSENST00000371591ENST00000489308ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-3CDSENST00000469134ENST00000313334ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-3CDSENST00000469134ENST00000313334ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
intron-3CDSENST00000469134ENST00000489308ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-3UTRENST00000371591ENST00000533836ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-3UTRENST00000469134ENST00000533836ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-3UTRENST00000469134ENST00000533836ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
intron-5UTRENST00000371591ENST00000472944ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-5UTRENST00000371591ENST00000484036ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-5UTRENST00000469134ENST00000472944ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-5UTRENST00000469134ENST00000472944ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
intron-5UTRENST00000469134ENST00000484036ZFYVE9chr1

52608075

+BTF3L4chr1

52530497

+
intron-5UTRENST00000469134ENST00000484036ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+
intron-intronENST00000469134ENST00000489308ZFYVE9chr1

52705267

+BTF3L4chr1

52549012

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357206ZFYVE9chr152705267+ENST00000313334BTF3L4chr152549012+661723501722658828
ENST00000287727ZFYVE9chr152705267+ENST00000313334BTF3L4chr152549012+661723501722658828
ENST00000371591ZFYVE9chr152705267+ENST00000313334BTF3L4chr152549012+657623091312617828

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357206ENST00000313334ZFYVE9chr152705267+BTF3L4chr152549012+0.0002376170.99976236
ENST00000287727ENST00000313334ZFYVE9chr152705267+BTF3L4chr152549012+0.0002376170.99976236
ENST00000371591ENST00000313334ZFYVE9chr152705267+BTF3L4chr152549012+0.0002285940.9997714

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Fusion Genomic Features for ZFYVE9-BTF3L4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZFYVE9chr152705267+BTF3L4chr152549011+2.10E-050.999979
ZFYVE9chr152608075+BTF3L4chr152530496+1.42E-111
ZFYVE9chr152705267+BTF3L4chr152549011+2.10E-050.999979
ZFYVE9chr152608075+BTF3L4chr152530496+1.42E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZFYVE9-BTF3L4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:52608075/chr1:52530497)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BTF3L4

Q96K17

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBTF3L4chr1:52705267chr1:52549012ENST000004729441533_980101.0DomainNAC-A/B
TgeneBTF3L4chr1:52705267chr1:52549012ENST000004893080533_98079.0DomainNAC-A/B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFYVE9chr1:52705267chr1:52549012ENST00000287727+419767_8237261426.0RegionNote=SBD
HgeneZFYVE9chr1:52705267chr1:52549012ENST00000357206+418767_8237261367.0RegionNote=SBD
HgeneZFYVE9chr1:52705267chr1:52549012ENST00000371591+318767_8237261426.0RegionNote=SBD
HgeneZFYVE9chr1:52705267chr1:52549012ENST00000287727+419699_7587261426.0Zinc fingerFYVE-type
HgeneZFYVE9chr1:52705267chr1:52549012ENST00000357206+418699_7587261367.0Zinc fingerFYVE-type
HgeneZFYVE9chr1:52705267chr1:52549012ENST00000371591+318699_7587261426.0Zinc fingerFYVE-type
TgeneBTF3L4chr1:52705267chr1:52549012ENST000003133342633_9856159.0DomainNAC-A/B


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Fusion Gene Sequence for ZFYVE9-BTF3L4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101187_101187_1_ZFYVE9-BTF3L4_ZFYVE9_chr1_52705267_ENST00000287727_BTF3L4_chr1_52549012_ENST00000313334_length(transcript)=6617nt_BP=2350nt
ATGCTGAAGCGGAGGCGGCCGCTGCTCGAGGATCAAACAGAGCATACTGAATCAGCAGGACTGGCTGGTGGTGCAGCAGACATCATGAGT
AAGCACCGAGAAGTCTGTTCCTTATCACGTGTGTAAGGGGAAAAAGGTTTAAACAAGTCTCTTAAGTGGTGTTTCCTCACCGATGGAGAA
TTACTTCCAAGCAGAAGCTTACAACCTGGACAAGGTGTTAGATGAATTTGAACAAAACGAAGATGAAACAGTTTCTTCTACTTTATTGGA
TACAAAGTGGAATAAGATTCTAGATCCCCCTTCTCACCGGCTGTCATTTAACCCTACTTTGGCCAGTGTGAATGAATCTGCAGTTTCTAA
TGAGTCACAACCACAACTGAAAGTCTTCTCCCTGGCTCATTCAGCTCCCCTGACCACAGAGGAAGAGGATCACTGTGCTAATGGACAGGA
CTGTAATCTAAATCCAGAGATTGCCACAATGTGGATTGATGAAAATGCTGTTGCAGAAGACCAGTTAATTAAGAGAAACTATAGTTGGGA
TGATCAATGCAGTGCTGTTGAAGTGGGAGAGAAGAAATGTGGAAACCTGGCTTGTCTGCCAGATGAGAAGAATGTTCTTGTTGTAGCCGT
CATGCATAACTGTGATAAAAGGACATTACAAAACGATTTACAGGATTGTAATAATTATAATAGTCAATCCCTTATGGATGCTTTTAGCTG
TTCACTGGATAATGAAAACAGACAAACTGATCAATTTAGTTTTAGTATAAATGAGTCCACTGAAAAAGATATGAATTCAGAGAAACAAAT
GGATCCATTGAATAGACCGAAAACAGAGGGGAGATCTGTTAACCATCTGTGTCCTACTTCATCTGATAGTCTAGCCAGTGTCTGTTCCCC
TTCACAATTAAAGGATGACGGAAGTATAGGTAGAGACCCCTCCATGTCTGCGATTACAAGTTTAACGGTTGATTCAGTAATCTCATCCCA
GGGAACAGATGGATGTCCTGCTGTTAAAAAGCAAGAGAACTATATACCAGATGAGGACCTCACTGGCAAAATCAGCTCTCCTAGGACAGA
TCTAGGGAGTCCAAATTCCTTTTCCCACATGAGTGAGGGGATTTTGATGAAAAAAGAGCCAGCAGAGGAGAGCACCACTGAAGAATCCCT
CCGGTCTGGTTTACCTTTGCTTCTCAAACCAGACATGCCTAATGGGTCTGGAAGGAATAATGACTGTGAACGGTGTTCAGATTGCCTTGT
GCCTAATGAAGTTAGGGCTGATGAAAATGAAGGTTATGAACATGAAGAAACTCTTGGCACTACAGAATTCCTTAATATGACAGAGCATTT
CTCTGAATCTCAGGACATGACTAATTGGAAGTTGACTAAACTAAATGAGATGAATGATAGCCAAGTAAACGAAGAAAAGGAAAAGTTTCT
ACAGATTAGTCAGCCTGAGGACACTAATGGTGATAGTGGAGGACAGTGTGTTGGATTGGCAGATGCAGGTCTAGATTTAAAAGGAACTTG
CATTAGTGAAAGTGAAGAATGTGATTTCTCCACTGTTATAGACACACCAGCAGCAAATTATCTATCTAATGGTTGTGATTCCTATGGAAT
GCAAGACCCAGGTGTTTCTTTTGTTCCAAAGACTTTACCCTCCAAAGAAGATTCAGTAACAGAAGAAAAAGAAATAGAGGAAAGCAAGTC
AGAATGCTACTCAAATATTTATGAACAGAGAGGAAATGAGGCCACAGAAGGGAGTGGACTACTTTTAAACAGCACTGGTGACCTAATGAA
GAAAAATTATTTACATAATTTCTGTAGTCAAGTTCCATCAGTGCTTGGGCAATCTTCCCCCAAGGTAGTAGCAAGCCTGCCATCTATCAG
TGTTCCTTTTGGTGGTGCAAGACCCAAGCAACCTTCTAATCTTAAACTTCAAATTCCAAAGCCATTATCAGACCATTTACAAAATGACTT
TCCTGCAAACAGTGGAAATAATACTAAAAATAAAAATGATATTCTTGGGAAAGCAAAATTAGGGGAAAACTCAGCAACCAATGTATGCAG
TCCATCTTTGGGAAACATCTCTAATGTCGATACAAATGGGGAACATTTAGAAAGTTATGAGGCTGAGATCTCCACTAGACCATGCCTTGC
ATTAGCTCCAGATAGCCCAGATAATGATCTCAGAGCTGGTCAGTTTGGAATTTCTGCCAGAAAGCCATTCACCACTCTGGGTGAGGTGGC
TCCAGTATGGGTACCGGATTCTCAGGCTCCAAATTGCATGAAATGTGAAGCCAGGTTTACATTCACCAAAAGGAGGCATCACTGCAGAGC
ATGTGGGAAGGTGAACATGATTAAAGATGATGGGACAGTTATTCATTTCAACAATCCCAAAGTCCAAGCTTCCCTTTCTGCTAATACCTT
TGCAATTACTGGTCATGCAGAAGCCAAACCAATCACAGAAATGCTTCCTGGAATATTAAGTCAGCTTGGTGCTGACAGTTTAACAAGCCT
TAGGAAGTTAGCTGAACAGTTCCCACGGCAAGTCTTGGACAGTAAAGCACCAAAACCAGAAGACATTGATGAGGAAGATGATGATGTTCC
AGATCTTGTAGAAAATTTTGATGAGGCATCAAAGAATGAAGCTAACTAAAAGTTTGGTTTTTGGAAGCTGGCATGGACTAGATTTAACAA
ATCAGCTATGTGGTTCCAAAGTTTTACAGACATGGAGAACATCACCTGTTACTAGTTCAGTAATATAAATATTTTGTATATTAATAATGC
TGTTTGTTCAGCATTTTTCGGTCATTTGATTTTGCATTTTGCACTTCCTCCCAGGATATTTTTTTGGTCAAAATATGAAGTATTGGTGCA
GTTTGAGGGTGTTTTGGTTTTTGATTCCTGGTTTTTTTGTTTTTTGTTTGGGGTATTTTTGGTGTATGTATGTTTATGTATGTGTGTGGG
TATGTGTGTATACAGTGGAGAGCAAATTGGAAAACAGTTCTATTTATCCTCCTCCCTCCCCAGTAGAAATAAAAAAAATCTTTACATTTG
TTACTTTTCTTTTCCCCCCGTAAGACACAGAATTAATGGAAAGTGAGTATCTTGGATTTCAAATCTGAAGAGATTTTTACCATTAGTGGT
TTGATTTTAATTTGCTTGGTTAACTATCATATTTTTCATACACTTCTCTGGATTTAAAATATCTTGAGGTATTTTGCCACTGGCTTCATG
CTGGAGTAATGGGTAACATATCTTTGGTATGGTTGCCTTAGATTAACTTACCTAGTCAGACCCAGAAGAACTTCTTTTACTAGCTTGCTT
CCTAAATGCCTTTTTTCCTCTCCTTTTGGTCTCCAAATGGCCTGGTCAGCTTTTGGTAATATTCTTCCTCATCTTCCACCTAGCTTGAGA
AGGATGTTCTCCATATAGAGTTTAGCGAGTGCCTAATCCCTCCTTTTGTAAGATTTTGTTCCCTCAGCTTGAGGAACAACTTCATCTTCA
ACTTTTTATTTCTCCCTGATGTTACAGTTTGGTAGATTTCAAACTGGAATAGCTAGCATGTGCTTGCTAAATAATTTTATGCCAGCCTTA
TCCTGTATCCTAGCTGTTCTTAACAGCAGGTACAAAAATGCCTGTTTTTCAGCAAGGTTGAAATTGGGAATGTCCTTTTGAATCAGAAGA
AAATAGGCCATAGACTCATCTCCCAGCACAAATGGGCATTCTATGAAATGGTACTGGCCCTAGGAGGATTTCCTCAACCACTCTCCTACT
CTTGGCCTTGAACCTACCTCTGGGTTGGATCTTACTATTGTAGCTGCTCACTATACCCTCCTGCATGCTTAGAATAATGCTTTGAGGGGA
GCACTGGTAAAACACAGTATTTATTTTTTTACCTCCTTTAAGAGGACTTGGAGGTAAGTTGCATTCATTCACTCAAGTTTCCCTCTTGCT
GTCTAATAGAAGCTTACTTTTTGCTATATCAGCATTTGTTACAGCCAATATTTAAGGACAAAATTTAGAAAATATATCATTTCCTGGCCC
ATCATCAAACTAATACAGCTTAACCTTGCAGCTACCAACTTTTGTGTCAAGCTAGATATCTTTATTTGATATCTAAGGTGCAAGACCAAC
AATATATTAAGAGATCTGTAGACATGAAGGCAAAGCTCTTGTATTTTTTTTCATCCAAACACCTCAATTTATTTTATAAATTCGTTCATT
TTTCCTGTTATGTTTTATATAATATATGGACTAAACAAAATAAAATAACAGTGCAAAAGAGGAGAATATTTCCTCTTGTGCTTTTCTTGA
TGTTGTGTACAGAATTTCCTTTTATATTATTCCTCTACCCTCCACCTGTAAATGAATGTTAGTGCAGTAATTGTTTGAAATAATGCCTCA
TCCAGTGTTAGGTCAGTAGCTCCACAGTCTACACAGTCCAGAATTCTTTCTCTAATTGTCCCAAAGGGGGACATTGTGGAGGCAGAGTTA
GGGGGAACCACTTCAAGTGGTTAGGGACAGATAAATAATAGGCAGTATAGCACATGAAAGAAAACACACACTTGGAAGCCAGGAGACTTG
TGTCCTAGTCAAAACTCTGGCATTATGTGACCTTGGACAGGTCATCTAACTACTCTGAAATTTATCATCAGTCAAATAAGATTTTATTCT
GTTTTGTTTTGTTTGAGATGGGGATTTGCTCTTGTTGTCCAGGCCGAACTGCAATGTTGTGGTCTCGGCTGACTGCAACCTCCACCTCCC
AGATTCAAGCGATTCTCCTGTCTCAGCCTCCACAGTAGCTGGGATTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGATGGGGTTTTACC
ATGTTGCCCAGGCCGGTCTTGAATTCCTGTCCTCAGGTGATTCATTTGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACT
GCACCCAGCCCAAATGAGATGTTTCTAAATCTAAAGTTTCTTCTGCTTCTGCATTTCTGTGAATCTCATTTGAAATTTTTCAGGGAAGGG
ATTTTATCATTTGTTCAGAGATGTCTTTATTTTTATTAATACCCATAAAACGTTTGTGTATTTGCTTCTTCCTCTTTCTCCTTTTGATCA
CATTTTAGCTACTTATCTAGAGGATCTCTGGCCAAGTATTCCCTTTTATTGTATTGATAACAATTCTTAATGGCTGGCCTCTCTTGTGTA
CAATGAGCCAATATTCTTTTTTGTTCTATATTTTTGTATCTTCCCCTTTCCTGAACAAAGCATATTTAGAGTCTCAAAGAAATCCTCTCC
ACAAAGACATGTTCCTCCCTCTGGTGTGGGTAGACATAGGGTAAGAGTTTGGATGAAACTTTTGTAAATTGTAGTGTTCTTGGCATAAAT
ATGAATTAAATCTTTTTTTATATTTAAATAACTAGTTAAATATGTGCTTCTTACTAAGATTAGGTATTTTTTGCCAAGATAACAATGATA
AAAACATTTTGGGGGGGAAATTGACCTTAAAATTTTGGGATAATTCAAGAAATGTCTGCAGAAAATTGATTTATGATCTTAATTTTTGTG
TTAGTCCTTTGAGGTTTTTTTGTTTTTGTTTTTGTTCTTTGTAAAGCGCCTTATCTGTTTTGGACAAGTCCAAAGTAAATGGTTGGGCTC
TTATATCTGTTTTACCCTTATTTTTCCCATTAAGTAATGGTTTAAGAATATATCAAGCACCTTAATTTGTTGTTAAGTAGCTAGTGCTTA
CAGGATTCCATTAAATTCACTTTAATAAGCCTATGAAGTTCTTATGAAAAACCCATATCTGCGATATGTTTGATTTGTTTCTTTGTTTTA
ATTCAGTGTTTAACCCTAGGTATGCTACATACCCATAAATAAGATACCATGGTAAGAGATAGTATGTTATAGTGGGAAAAGCACAAGTTT
TTAGATAGAGATCAATTCTGCTATCTACCCTTACATTGTAACCTTTCTGACAGGGCTGCTGCGGTGCACAACTTCGGGAGCCATCACTTA
TTTTTGTTGTGTTCCAGAAGGTGTCATTTTCATAGACTGCAGTGTGAATAGTGTCCTCCATTAATAATGCAATGATGGCCTTGCTCTCTG
AGCCTCAGTTTTATCTATAAAATGGTACCTAGAAGAGTCATGATTTCTTAGAATCCCCTAAATTATTAAGGTGAAGGTAGAAGATGATTA
AAGCGTGTTATCTCCTAAGCTATGGCTTAGATTTTCCGAAGCTCATGGTTCTAGGCACAGAAAGTCTCCATTCTACACTGCATTTCAACC
TGTGTTGAACAACACTCCAGTTCAGCCTGTATTGCTATGCCACATAGAGTTTGCCTGAATTATTATAGCTTTCTTAATAGTTTTGTTTAT
GATCCACTCTCTCCAGCCCATTACACAGGAGCCAGCTACCTAAATTTCCTATCTGAGCATGTCCTTACATTTACTTCCAGCATACTATTC
ATTTGCCATAGTAGAGTATTAAGATTATTTGATTTTCTTTTTACTTTCTCGTAGTGCCCAATGTGTAGTTTACTCAACATCATAATATGT

>101187_101187_1_ZFYVE9-BTF3L4_ZFYVE9_chr1_52705267_ENST00000287727_BTF3L4_chr1_52549012_ENST00000313334_length(amino acids)=828AA_BP=726
MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPSHRLSFNPTLASVNESAVSNESQPQLKVFSLAHSAPLTTEEEDHCAN
GQDCNLNPEIATMWIDENAVAEDQLIKRNYSWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTLQNDLQDCNNYNSQSLMDA
FSCSLDNENRQTDQFSFSINESTEKDMNSEKQMDPLNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVI
SSQGTDGCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESLRSGLPLLLKPDMPNGSGRNNDCERCSD
CLVPNEVRADENEGYEHEETLGTTEFLNMTEHFSESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSGGQCVGLADAGLDLK
GTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGD
LMKKNYLHNFCSQVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDFPANSGNNTKNKNDILGKAKLGENSATN
VCSPSLGNISNVDTNGEHLESYEAEISTRPCLALAPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHH
CRACGKVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDD

--------------------------------------------------------------
>101187_101187_2_ZFYVE9-BTF3L4_ZFYVE9_chr1_52705267_ENST00000357206_BTF3L4_chr1_52549012_ENST00000313334_length(transcript)=6617nt_BP=2350nt
ATGCTGAAGCGGAGGCGGCCGCTGCTCGAGGATCAAACAGAGCATACTGAATCAGCAGGACTGGCTGGTGGTGCAGCAGACATCATGAGT
AAGCACCGAGAAGTCTGTTCCTTATCACGTGTGTAAGGGGAAAAAGGTTTAAACAAGTCTCTTAAGTGGTGTTTCCTCACCGATGGAGAA
TTACTTCCAAGCAGAAGCTTACAACCTGGACAAGGTGTTAGATGAATTTGAACAAAACGAAGATGAAACAGTTTCTTCTACTTTATTGGA
TACAAAGTGGAATAAGATTCTAGATCCCCCTTCTCACCGGCTGTCATTTAACCCTACTTTGGCCAGTGTGAATGAATCTGCAGTTTCTAA
TGAGTCACAACCACAACTGAAAGTCTTCTCCCTGGCTCATTCAGCTCCCCTGACCACAGAGGAAGAGGATCACTGTGCTAATGGACAGGA
CTGTAATCTAAATCCAGAGATTGCCACAATGTGGATTGATGAAAATGCTGTTGCAGAAGACCAGTTAATTAAGAGAAACTATAGTTGGGA
TGATCAATGCAGTGCTGTTGAAGTGGGAGAGAAGAAATGTGGAAACCTGGCTTGTCTGCCAGATGAGAAGAATGTTCTTGTTGTAGCCGT
CATGCATAACTGTGATAAAAGGACATTACAAAACGATTTACAGGATTGTAATAATTATAATAGTCAATCCCTTATGGATGCTTTTAGCTG
TTCACTGGATAATGAAAACAGACAAACTGATCAATTTAGTTTTAGTATAAATGAGTCCACTGAAAAAGATATGAATTCAGAGAAACAAAT
GGATCCATTGAATAGACCGAAAACAGAGGGGAGATCTGTTAACCATCTGTGTCCTACTTCATCTGATAGTCTAGCCAGTGTCTGTTCCCC
TTCACAATTAAAGGATGACGGAAGTATAGGTAGAGACCCCTCCATGTCTGCGATTACAAGTTTAACGGTTGATTCAGTAATCTCATCCCA
GGGAACAGATGGATGTCCTGCTGTTAAAAAGCAAGAGAACTATATACCAGATGAGGACCTCACTGGCAAAATCAGCTCTCCTAGGACAGA
TCTAGGGAGTCCAAATTCCTTTTCCCACATGAGTGAGGGGATTTTGATGAAAAAAGAGCCAGCAGAGGAGAGCACCACTGAAGAATCCCT
CCGGTCTGGTTTACCTTTGCTTCTCAAACCAGACATGCCTAATGGGTCTGGAAGGAATAATGACTGTGAACGGTGTTCAGATTGCCTTGT
GCCTAATGAAGTTAGGGCTGATGAAAATGAAGGTTATGAACATGAAGAAACTCTTGGCACTACAGAATTCCTTAATATGACAGAGCATTT
CTCTGAATCTCAGGACATGACTAATTGGAAGTTGACTAAACTAAATGAGATGAATGATAGCCAAGTAAACGAAGAAAAGGAAAAGTTTCT
ACAGATTAGTCAGCCTGAGGACACTAATGGTGATAGTGGAGGACAGTGTGTTGGATTGGCAGATGCAGGTCTAGATTTAAAAGGAACTTG
CATTAGTGAAAGTGAAGAATGTGATTTCTCCACTGTTATAGACACACCAGCAGCAAATTATCTATCTAATGGTTGTGATTCCTATGGAAT
GCAAGACCCAGGTGTTTCTTTTGTTCCAAAGACTTTACCCTCCAAAGAAGATTCAGTAACAGAAGAAAAAGAAATAGAGGAAAGCAAGTC
AGAATGCTACTCAAATATTTATGAACAGAGAGGAAATGAGGCCACAGAAGGGAGTGGACTACTTTTAAACAGCACTGGTGACCTAATGAA
GAAAAATTATTTACATAATTTCTGTAGTCAAGTTCCATCAGTGCTTGGGCAATCTTCCCCCAAGGTAGTAGCAAGCCTGCCATCTATCAG
TGTTCCTTTTGGTGGTGCAAGACCCAAGCAACCTTCTAATCTTAAACTTCAAATTCCAAAGCCATTATCAGACCATTTACAAAATGACTT
TCCTGCAAACAGTGGAAATAATACTAAAAATAAAAATGATATTCTTGGGAAAGCAAAATTAGGGGAAAACTCAGCAACCAATGTATGCAG
TCCATCTTTGGGAAACATCTCTAATGTCGATACAAATGGGGAACATTTAGAAAGTTATGAGGCTGAGATCTCCACTAGACCATGCCTTGC
ATTAGCTCCAGATAGCCCAGATAATGATCTCAGAGCTGGTCAGTTTGGAATTTCTGCCAGAAAGCCATTCACCACTCTGGGTGAGGTGGC
TCCAGTATGGGTACCGGATTCTCAGGCTCCAAATTGCATGAAATGTGAAGCCAGGTTTACATTCACCAAAAGGAGGCATCACTGCAGAGC
ATGTGGGAAGGTGAACATGATTAAAGATGATGGGACAGTTATTCATTTCAACAATCCCAAAGTCCAAGCTTCCCTTTCTGCTAATACCTT
TGCAATTACTGGTCATGCAGAAGCCAAACCAATCACAGAAATGCTTCCTGGAATATTAAGTCAGCTTGGTGCTGACAGTTTAACAAGCCT
TAGGAAGTTAGCTGAACAGTTCCCACGGCAAGTCTTGGACAGTAAAGCACCAAAACCAGAAGACATTGATGAGGAAGATGATGATGTTCC
AGATCTTGTAGAAAATTTTGATGAGGCATCAAAGAATGAAGCTAACTAAAAGTTTGGTTTTTGGAAGCTGGCATGGACTAGATTTAACAA
ATCAGCTATGTGGTTCCAAAGTTTTACAGACATGGAGAACATCACCTGTTACTAGTTCAGTAATATAAATATTTTGTATATTAATAATGC
TGTTTGTTCAGCATTTTTCGGTCATTTGATTTTGCATTTTGCACTTCCTCCCAGGATATTTTTTTGGTCAAAATATGAAGTATTGGTGCA
GTTTGAGGGTGTTTTGGTTTTTGATTCCTGGTTTTTTTGTTTTTTGTTTGGGGTATTTTTGGTGTATGTATGTTTATGTATGTGTGTGGG
TATGTGTGTATACAGTGGAGAGCAAATTGGAAAACAGTTCTATTTATCCTCCTCCCTCCCCAGTAGAAATAAAAAAAATCTTTACATTTG
TTACTTTTCTTTTCCCCCCGTAAGACACAGAATTAATGGAAAGTGAGTATCTTGGATTTCAAATCTGAAGAGATTTTTACCATTAGTGGT
TTGATTTTAATTTGCTTGGTTAACTATCATATTTTTCATACACTTCTCTGGATTTAAAATATCTTGAGGTATTTTGCCACTGGCTTCATG
CTGGAGTAATGGGTAACATATCTTTGGTATGGTTGCCTTAGATTAACTTACCTAGTCAGACCCAGAAGAACTTCTTTTACTAGCTTGCTT
CCTAAATGCCTTTTTTCCTCTCCTTTTGGTCTCCAAATGGCCTGGTCAGCTTTTGGTAATATTCTTCCTCATCTTCCACCTAGCTTGAGA
AGGATGTTCTCCATATAGAGTTTAGCGAGTGCCTAATCCCTCCTTTTGTAAGATTTTGTTCCCTCAGCTTGAGGAACAACTTCATCTTCA
ACTTTTTATTTCTCCCTGATGTTACAGTTTGGTAGATTTCAAACTGGAATAGCTAGCATGTGCTTGCTAAATAATTTTATGCCAGCCTTA
TCCTGTATCCTAGCTGTTCTTAACAGCAGGTACAAAAATGCCTGTTTTTCAGCAAGGTTGAAATTGGGAATGTCCTTTTGAATCAGAAGA
AAATAGGCCATAGACTCATCTCCCAGCACAAATGGGCATTCTATGAAATGGTACTGGCCCTAGGAGGATTTCCTCAACCACTCTCCTACT
CTTGGCCTTGAACCTACCTCTGGGTTGGATCTTACTATTGTAGCTGCTCACTATACCCTCCTGCATGCTTAGAATAATGCTTTGAGGGGA
GCACTGGTAAAACACAGTATTTATTTTTTTACCTCCTTTAAGAGGACTTGGAGGTAAGTTGCATTCATTCACTCAAGTTTCCCTCTTGCT
GTCTAATAGAAGCTTACTTTTTGCTATATCAGCATTTGTTACAGCCAATATTTAAGGACAAAATTTAGAAAATATATCATTTCCTGGCCC
ATCATCAAACTAATACAGCTTAACCTTGCAGCTACCAACTTTTGTGTCAAGCTAGATATCTTTATTTGATATCTAAGGTGCAAGACCAAC
AATATATTAAGAGATCTGTAGACATGAAGGCAAAGCTCTTGTATTTTTTTTCATCCAAACACCTCAATTTATTTTATAAATTCGTTCATT
TTTCCTGTTATGTTTTATATAATATATGGACTAAACAAAATAAAATAACAGTGCAAAAGAGGAGAATATTTCCTCTTGTGCTTTTCTTGA
TGTTGTGTACAGAATTTCCTTTTATATTATTCCTCTACCCTCCACCTGTAAATGAATGTTAGTGCAGTAATTGTTTGAAATAATGCCTCA
TCCAGTGTTAGGTCAGTAGCTCCACAGTCTACACAGTCCAGAATTCTTTCTCTAATTGTCCCAAAGGGGGACATTGTGGAGGCAGAGTTA
GGGGGAACCACTTCAAGTGGTTAGGGACAGATAAATAATAGGCAGTATAGCACATGAAAGAAAACACACACTTGGAAGCCAGGAGACTTG
TGTCCTAGTCAAAACTCTGGCATTATGTGACCTTGGACAGGTCATCTAACTACTCTGAAATTTATCATCAGTCAAATAAGATTTTATTCT
GTTTTGTTTTGTTTGAGATGGGGATTTGCTCTTGTTGTCCAGGCCGAACTGCAATGTTGTGGTCTCGGCTGACTGCAACCTCCACCTCCC
AGATTCAAGCGATTCTCCTGTCTCAGCCTCCACAGTAGCTGGGATTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGATGGGGTTTTACC
ATGTTGCCCAGGCCGGTCTTGAATTCCTGTCCTCAGGTGATTCATTTGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACT
GCACCCAGCCCAAATGAGATGTTTCTAAATCTAAAGTTTCTTCTGCTTCTGCATTTCTGTGAATCTCATTTGAAATTTTTCAGGGAAGGG
ATTTTATCATTTGTTCAGAGATGTCTTTATTTTTATTAATACCCATAAAACGTTTGTGTATTTGCTTCTTCCTCTTTCTCCTTTTGATCA
CATTTTAGCTACTTATCTAGAGGATCTCTGGCCAAGTATTCCCTTTTATTGTATTGATAACAATTCTTAATGGCTGGCCTCTCTTGTGTA
CAATGAGCCAATATTCTTTTTTGTTCTATATTTTTGTATCTTCCCCTTTCCTGAACAAAGCATATTTAGAGTCTCAAAGAAATCCTCTCC
ACAAAGACATGTTCCTCCCTCTGGTGTGGGTAGACATAGGGTAAGAGTTTGGATGAAACTTTTGTAAATTGTAGTGTTCTTGGCATAAAT
ATGAATTAAATCTTTTTTTATATTTAAATAACTAGTTAAATATGTGCTTCTTACTAAGATTAGGTATTTTTTGCCAAGATAACAATGATA
AAAACATTTTGGGGGGGAAATTGACCTTAAAATTTTGGGATAATTCAAGAAATGTCTGCAGAAAATTGATTTATGATCTTAATTTTTGTG
TTAGTCCTTTGAGGTTTTTTTGTTTTTGTTTTTGTTCTTTGTAAAGCGCCTTATCTGTTTTGGACAAGTCCAAAGTAAATGGTTGGGCTC
TTATATCTGTTTTACCCTTATTTTTCCCATTAAGTAATGGTTTAAGAATATATCAAGCACCTTAATTTGTTGTTAAGTAGCTAGTGCTTA
CAGGATTCCATTAAATTCACTTTAATAAGCCTATGAAGTTCTTATGAAAAACCCATATCTGCGATATGTTTGATTTGTTTCTTTGTTTTA
ATTCAGTGTTTAACCCTAGGTATGCTACATACCCATAAATAAGATACCATGGTAAGAGATAGTATGTTATAGTGGGAAAAGCACAAGTTT
TTAGATAGAGATCAATTCTGCTATCTACCCTTACATTGTAACCTTTCTGACAGGGCTGCTGCGGTGCACAACTTCGGGAGCCATCACTTA
TTTTTGTTGTGTTCCAGAAGGTGTCATTTTCATAGACTGCAGTGTGAATAGTGTCCTCCATTAATAATGCAATGATGGCCTTGCTCTCTG
AGCCTCAGTTTTATCTATAAAATGGTACCTAGAAGAGTCATGATTTCTTAGAATCCCCTAAATTATTAAGGTGAAGGTAGAAGATGATTA
AAGCGTGTTATCTCCTAAGCTATGGCTTAGATTTTCCGAAGCTCATGGTTCTAGGCACAGAAAGTCTCCATTCTACACTGCATTTCAACC
TGTGTTGAACAACACTCCAGTTCAGCCTGTATTGCTATGCCACATAGAGTTTGCCTGAATTATTATAGCTTTCTTAATAGTTTTGTTTAT
GATCCACTCTCTCCAGCCCATTACACAGGAGCCAGCTACCTAAATTTCCTATCTGAGCATGTCCTTACATTTACTTCCAGCATACTATTC
ATTTGCCATAGTAGAGTATTAAGATTATTTGATTTTCTTTTTACTTTCTCGTAGTGCCCAATGTGTAGTTTACTCAACATCATAATATGT

>101187_101187_2_ZFYVE9-BTF3L4_ZFYVE9_chr1_52705267_ENST00000357206_BTF3L4_chr1_52549012_ENST00000313334_length(amino acids)=828AA_BP=726
MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPSHRLSFNPTLASVNESAVSNESQPQLKVFSLAHSAPLTTEEEDHCAN
GQDCNLNPEIATMWIDENAVAEDQLIKRNYSWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTLQNDLQDCNNYNSQSLMDA
FSCSLDNENRQTDQFSFSINESTEKDMNSEKQMDPLNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVI
SSQGTDGCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESLRSGLPLLLKPDMPNGSGRNNDCERCSD
CLVPNEVRADENEGYEHEETLGTTEFLNMTEHFSESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSGGQCVGLADAGLDLK
GTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGD
LMKKNYLHNFCSQVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDFPANSGNNTKNKNDILGKAKLGENSATN
VCSPSLGNISNVDTNGEHLESYEAEISTRPCLALAPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHH
CRACGKVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDD

--------------------------------------------------------------
>101187_101187_3_ZFYVE9-BTF3L4_ZFYVE9_chr1_52705267_ENST00000371591_BTF3L4_chr1_52549012_ENST00000313334_length(transcript)=6576nt_BP=2309nt
GCATACTGAATCAGCAGGACTGGCTGGTGGTGCAGCAGACATCATGAGTAAGCACCGAGAAGTCTGTTCCTTATCACGTGTGTAAGGGGA
AAAAGGTTTAAACAAGTCTCTTAAGTGGTGTTTCCTCACCGATGGAGAATTACTTCCAAGCAGAAGCTTACAACCTGGACAAGGTGTTAG
ATGAATTTGAACAAAACGAAGATGAAACAGTTTCTTCTACTTTATTGGATACAAAGTGGAATAAGATTCTAGATCCCCCTTCTCACCGGC
TGTCATTTAACCCTACTTTGGCCAGTGTGAATGAATCTGCAGTTTCTAATGAGTCACAACCACAACTGAAAGTCTTCTCCCTGGCTCATT
CAGCTCCCCTGACCACAGAGGAAGAGGATCACTGTGCTAATGGACAGGACTGTAATCTAAATCCAGAGATTGCCACAATGTGGATTGATG
AAAATGCTGTTGCAGAAGACCAGTTAATTAAGAGAAACTATAGTTGGGATGATCAATGCAGTGCTGTTGAAGTGGGAGAGAAGAAATGTG
GAAACCTGGCTTGTCTGCCAGATGAGAAGAATGTTCTTGTTGTAGCCGTCATGCATAACTGTGATAAAAGGACATTACAAAACGATTTAC
AGGATTGTAATAATTATAATAGTCAATCCCTTATGGATGCTTTTAGCTGTTCACTGGATAATGAAAACAGACAAACTGATCAATTTAGTT
TTAGTATAAATGAGTCCACTGAAAAAGATATGAATTCAGAGAAACAAATGGATCCATTGAATAGACCGAAAACAGAGGGGAGATCTGTTA
ACCATCTGTGTCCTACTTCATCTGATAGTCTAGCCAGTGTCTGTTCCCCTTCACAATTAAAGGATGACGGAAGTATAGGTAGAGACCCCT
CCATGTCTGCGATTACAAGTTTAACGGTTGATTCAGTAATCTCATCCCAGGGAACAGATGGATGTCCTGCTGTTAAAAAGCAAGAGAACT
ATATACCAGATGAGGACCTCACTGGCAAAATCAGCTCTCCTAGGACAGATCTAGGGAGTCCAAATTCCTTTTCCCACATGAGTGAGGGGA
TTTTGATGAAAAAAGAGCCAGCAGAGGAGAGCACCACTGAAGAATCCCTCCGGTCTGGTTTACCTTTGCTTCTCAAACCAGACATGCCTA
ATGGGTCTGGAAGGAATAATGACTGTGAACGGTGTTCAGATTGCCTTGTGCCTAATGAAGTTAGGGCTGATGAAAATGAAGGTTATGAAC
ATGAAGAAACTCTTGGCACTACAGAATTCCTTAATATGACAGAGCATTTCTCTGAATCTCAGGACATGACTAATTGGAAGTTGACTAAAC
TAAATGAGATGAATGATAGCCAAGTAAACGAAGAAAAGGAAAAGTTTCTACAGATTAGTCAGCCTGAGGACACTAATGGTGATAGTGGAG
GACAGTGTGTTGGATTGGCAGATGCAGGTCTAGATTTAAAAGGAACTTGCATTAGTGAAAGTGAAGAATGTGATTTCTCCACTGTTATAG
ACACACCAGCAGCAAATTATCTATCTAATGGTTGTGATTCCTATGGAATGCAAGACCCAGGTGTTTCTTTTGTTCCAAAGACTTTACCCT
CCAAAGAAGATTCAGTAACAGAAGAAAAAGAAATAGAGGAAAGCAAGTCAGAATGCTACTCAAATATTTATGAACAGAGAGGAAATGAGG
CCACAGAAGGGAGTGGACTACTTTTAAACAGCACTGGTGACCTAATGAAGAAAAATTATTTACATAATTTCTGTAGTCAAGTTCCATCAG
TGCTTGGGCAATCTTCCCCCAAGGTAGTAGCAAGCCTGCCATCTATCAGTGTTCCTTTTGGTGGTGCAAGACCCAAGCAACCTTCTAATC
TTAAACTTCAAATTCCAAAGCCATTATCAGACCATTTACAAAATGACTTTCCTGCAAACAGTGGAAATAATACTAAAAATAAAAATGATA
TTCTTGGGAAAGCAAAATTAGGGGAAAACTCAGCAACCAATGTATGCAGTCCATCTTTGGGAAACATCTCTAATGTCGATACAAATGGGG
AACATTTAGAAAGTTATGAGGCTGAGATCTCCACTAGACCATGCCTTGCATTAGCTCCAGATAGCCCAGATAATGATCTCAGAGCTGGTC
AGTTTGGAATTTCTGCCAGAAAGCCATTCACCACTCTGGGTGAGGTGGCTCCAGTATGGGTACCGGATTCTCAGGCTCCAAATTGCATGA
AATGTGAAGCCAGGTTTACATTCACCAAAAGGAGGCATCACTGCAGAGCATGTGGGAAGGTGAACATGATTAAAGATGATGGGACAGTTA
TTCATTTCAACAATCCCAAAGTCCAAGCTTCCCTTTCTGCTAATACCTTTGCAATTACTGGTCATGCAGAAGCCAAACCAATCACAGAAA
TGCTTCCTGGAATATTAAGTCAGCTTGGTGCTGACAGTTTAACAAGCCTTAGGAAGTTAGCTGAACAGTTCCCACGGCAAGTCTTGGACA
GTAAAGCACCAAAACCAGAAGACATTGATGAGGAAGATGATGATGTTCCAGATCTTGTAGAAAATTTTGATGAGGCATCAAAGAATGAAG
CTAACTAAAAGTTTGGTTTTTGGAAGCTGGCATGGACTAGATTTAACAAATCAGCTATGTGGTTCCAAAGTTTTACAGACATGGAGAACA
TCACCTGTTACTAGTTCAGTAATATAAATATTTTGTATATTAATAATGCTGTTTGTTCAGCATTTTTCGGTCATTTGATTTTGCATTTTG
CACTTCCTCCCAGGATATTTTTTTGGTCAAAATATGAAGTATTGGTGCAGTTTGAGGGTGTTTTGGTTTTTGATTCCTGGTTTTTTTGTT
TTTTGTTTGGGGTATTTTTGGTGTATGTATGTTTATGTATGTGTGTGGGTATGTGTGTATACAGTGGAGAGCAAATTGGAAAACAGTTCT
ATTTATCCTCCTCCCTCCCCAGTAGAAATAAAAAAAATCTTTACATTTGTTACTTTTCTTTTCCCCCCGTAAGACACAGAATTAATGGAA
AGTGAGTATCTTGGATTTCAAATCTGAAGAGATTTTTACCATTAGTGGTTTGATTTTAATTTGCTTGGTTAACTATCATATTTTTCATAC
ACTTCTCTGGATTTAAAATATCTTGAGGTATTTTGCCACTGGCTTCATGCTGGAGTAATGGGTAACATATCTTTGGTATGGTTGCCTTAG
ATTAACTTACCTAGTCAGACCCAGAAGAACTTCTTTTACTAGCTTGCTTCCTAAATGCCTTTTTTCCTCTCCTTTTGGTCTCCAAATGGC
CTGGTCAGCTTTTGGTAATATTCTTCCTCATCTTCCACCTAGCTTGAGAAGGATGTTCTCCATATAGAGTTTAGCGAGTGCCTAATCCCT
CCTTTTGTAAGATTTTGTTCCCTCAGCTTGAGGAACAACTTCATCTTCAACTTTTTATTTCTCCCTGATGTTACAGTTTGGTAGATTTCA
AACTGGAATAGCTAGCATGTGCTTGCTAAATAATTTTATGCCAGCCTTATCCTGTATCCTAGCTGTTCTTAACAGCAGGTACAAAAATGC
CTGTTTTTCAGCAAGGTTGAAATTGGGAATGTCCTTTTGAATCAGAAGAAAATAGGCCATAGACTCATCTCCCAGCACAAATGGGCATTC
TATGAAATGGTACTGGCCCTAGGAGGATTTCCTCAACCACTCTCCTACTCTTGGCCTTGAACCTACCTCTGGGTTGGATCTTACTATTGT
AGCTGCTCACTATACCCTCCTGCATGCTTAGAATAATGCTTTGAGGGGAGCACTGGTAAAACACAGTATTTATTTTTTTACCTCCTTTAA
GAGGACTTGGAGGTAAGTTGCATTCATTCACTCAAGTTTCCCTCTTGCTGTCTAATAGAAGCTTACTTTTTGCTATATCAGCATTTGTTA
CAGCCAATATTTAAGGACAAAATTTAGAAAATATATCATTTCCTGGCCCATCATCAAACTAATACAGCTTAACCTTGCAGCTACCAACTT
TTGTGTCAAGCTAGATATCTTTATTTGATATCTAAGGTGCAAGACCAACAATATATTAAGAGATCTGTAGACATGAAGGCAAAGCTCTTG
TATTTTTTTTCATCCAAACACCTCAATTTATTTTATAAATTCGTTCATTTTTCCTGTTATGTTTTATATAATATATGGACTAAACAAAAT
AAAATAACAGTGCAAAAGAGGAGAATATTTCCTCTTGTGCTTTTCTTGATGTTGTGTACAGAATTTCCTTTTATATTATTCCTCTACCCT
CCACCTGTAAATGAATGTTAGTGCAGTAATTGTTTGAAATAATGCCTCATCCAGTGTTAGGTCAGTAGCTCCACAGTCTACACAGTCCAG
AATTCTTTCTCTAATTGTCCCAAAGGGGGACATTGTGGAGGCAGAGTTAGGGGGAACCACTTCAAGTGGTTAGGGACAGATAAATAATAG
GCAGTATAGCACATGAAAGAAAACACACACTTGGAAGCCAGGAGACTTGTGTCCTAGTCAAAACTCTGGCATTATGTGACCTTGGACAGG
TCATCTAACTACTCTGAAATTTATCATCAGTCAAATAAGATTTTATTCTGTTTTGTTTTGTTTGAGATGGGGATTTGCTCTTGTTGTCCA
GGCCGAACTGCAATGTTGTGGTCTCGGCTGACTGCAACCTCCACCTCCCAGATTCAAGCGATTCTCCTGTCTCAGCCTCCACAGTAGCTG
GGATTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGCCCAGGCCGGTCTTGAATTCCTGTCCTCAGGTGAT
TCATTTGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACTGCACCCAGCCCAAATGAGATGTTTCTAAATCTAAAGTTTCT
TCTGCTTCTGCATTTCTGTGAATCTCATTTGAAATTTTTCAGGGAAGGGATTTTATCATTTGTTCAGAGATGTCTTTATTTTTATTAATA
CCCATAAAACGTTTGTGTATTTGCTTCTTCCTCTTTCTCCTTTTGATCACATTTTAGCTACTTATCTAGAGGATCTCTGGCCAAGTATTC
CCTTTTATTGTATTGATAACAATTCTTAATGGCTGGCCTCTCTTGTGTACAATGAGCCAATATTCTTTTTTGTTCTATATTTTTGTATCT
TCCCCTTTCCTGAACAAAGCATATTTAGAGTCTCAAAGAAATCCTCTCCACAAAGACATGTTCCTCCCTCTGGTGTGGGTAGACATAGGG
TAAGAGTTTGGATGAAACTTTTGTAAATTGTAGTGTTCTTGGCATAAATATGAATTAAATCTTTTTTTATATTTAAATAACTAGTTAAAT
ATGTGCTTCTTACTAAGATTAGGTATTTTTTGCCAAGATAACAATGATAAAAACATTTTGGGGGGGAAATTGACCTTAAAATTTTGGGAT
AATTCAAGAAATGTCTGCAGAAAATTGATTTATGATCTTAATTTTTGTGTTAGTCCTTTGAGGTTTTTTTGTTTTTGTTTTTGTTCTTTG
TAAAGCGCCTTATCTGTTTTGGACAAGTCCAAAGTAAATGGTTGGGCTCTTATATCTGTTTTACCCTTATTTTTCCCATTAAGTAATGGT
TTAAGAATATATCAAGCACCTTAATTTGTTGTTAAGTAGCTAGTGCTTACAGGATTCCATTAAATTCACTTTAATAAGCCTATGAAGTTC
TTATGAAAAACCCATATCTGCGATATGTTTGATTTGTTTCTTTGTTTTAATTCAGTGTTTAACCCTAGGTATGCTACATACCCATAAATA
AGATACCATGGTAAGAGATAGTATGTTATAGTGGGAAAAGCACAAGTTTTTAGATAGAGATCAATTCTGCTATCTACCCTTACATTGTAA
CCTTTCTGACAGGGCTGCTGCGGTGCACAACTTCGGGAGCCATCACTTATTTTTGTTGTGTTCCAGAAGGTGTCATTTTCATAGACTGCA
GTGTGAATAGTGTCCTCCATTAATAATGCAATGATGGCCTTGCTCTCTGAGCCTCAGTTTTATCTATAAAATGGTACCTAGAAGAGTCAT
GATTTCTTAGAATCCCCTAAATTATTAAGGTGAAGGTAGAAGATGATTAAAGCGTGTTATCTCCTAAGCTATGGCTTAGATTTTCCGAAG
CTCATGGTTCTAGGCACAGAAAGTCTCCATTCTACACTGCATTTCAACCTGTGTTGAACAACACTCCAGTTCAGCCTGTATTGCTATGCC
ACATAGAGTTTGCCTGAATTATTATAGCTTTCTTAATAGTTTTGTTTATGATCCACTCTCTCCAGCCCATTACACAGGAGCCAGCTACCT
AAATTTCCTATCTGAGCATGTCCTTACATTTACTTCCAGCATACTATTCATTTGCCATAGTAGAGTATTAAGATTATTTGATTTTCTTTT
TACTTTCTCGTAGTGCCCAATGTGTAGTTTACTCAACATCATAATATGTAATGTTTTTCAACTACTTACTGTTGAATACAAAGTTATCTC

>101187_101187_3_ZFYVE9-BTF3L4_ZFYVE9_chr1_52705267_ENST00000371591_BTF3L4_chr1_52549012_ENST00000313334_length(amino acids)=828AA_BP=726
MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPSHRLSFNPTLASVNESAVSNESQPQLKVFSLAHSAPLTTEEEDHCAN
GQDCNLNPEIATMWIDENAVAEDQLIKRNYSWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTLQNDLQDCNNYNSQSLMDA
FSCSLDNENRQTDQFSFSINESTEKDMNSEKQMDPLNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVI
SSQGTDGCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESLRSGLPLLLKPDMPNGSGRNNDCERCSD
CLVPNEVRADENEGYEHEETLGTTEFLNMTEHFSESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSGGQCVGLADAGLDLK
GTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGD
LMKKNYLHNFCSQVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDFPANSGNNTKNKNDILGKAKLGENSATN
VCSPSLGNISNVDTNGEHLESYEAEISTRPCLALAPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHH
CRACGKVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDD

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Fusion Gene PPI Analysis for ZFYVE9-BTF3L4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZFYVE9-BTF3L4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZFYVE9-BTF3L4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource