FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ZG16B-PRH2 (FusionGDB2 ID:101193)

Fusion Gene Summary for ZG16B-PRH2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZG16B-PRH2
Fusion gene ID: 101193
HgeneTgene
Gene symbol

ZG16B

PRH2

Gene ID

124220

5555

Gene namezymogen granule protein 16Bproline rich protein HaeIII subfamily 2
SynonymsEECP|HRPE773|JCLN2|PAUF|PRO1567PRP-1/PRP-2|Pr|pr1/Pr2
Cytomap

16p13.3

12p13.2

Type of geneprotein-codingprotein-coding
Descriptionzymogen granule protein 16 homolog Bendocrine and exocrine proteinjacalin-like lectin domain containing 2pancreatic adenocarcinoma upregulated factorsalivary acidic proline-rich phosphoprotein 1/2acidic salivary proline-rich protein, HaeIII type, 2parotid acidic proteinparotid double-band proteinparotid proline-rich protein 1/2protein C
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000382280, ENST00000572863, 
ENST00000381847, ENST00000396400, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 11 X 5=385
# samples 17
** MAII scorelog2(1/4*10)=1.32192809488736log2(7/385*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZG16B [Title/Abstract] AND PRH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZG16B(2881946)-PRH2(11083485), # samples:1
ZG16B(2881946)-PRH2(11083536), # samples:1
ZG16B(2881946)-PRH2(11083629), # samples:1
ZG16B(2881954)-PRH2(11083493), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZG16B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6933ZG16Bchr16

2881946

+PRH2chr12

11083485

+
ChimerDB4HNSCTCGA-CV-6933ZG16Bchr16

2881946

+PRH2chr12

11083536

+
ChimerDB4HNSCTCGA-CV-6933ZG16Bchr16

2881946

+PRH2chr12

11083629

+
ChimerDB4HNSCTCGA-CV-6933ZG16Bchr16

2881954

+PRH2chr12

11083493

+


Top

Fusion Gene ORF analysis for ZG16B-PRH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000382280ENST00000381847ZG16Bchr16

2881946

+PRH2chr12

11083485

+
Frame-shiftENST00000382280ENST00000381847ZG16Bchr16

2881946

+PRH2chr12

11083536

+
Frame-shiftENST00000382280ENST00000381847ZG16Bchr16

2881946

+PRH2chr12

11083629

+
Frame-shiftENST00000382280ENST00000381847ZG16Bchr16

2881954

+PRH2chr12

11083493

+
Frame-shiftENST00000382280ENST00000396400ZG16Bchr16

2881946

+PRH2chr12

11083485

+
Frame-shiftENST00000382280ENST00000396400ZG16Bchr16

2881946

+PRH2chr12

11083536

+
Frame-shiftENST00000382280ENST00000396400ZG16Bchr16

2881946

+PRH2chr12

11083629

+
Frame-shiftENST00000382280ENST00000396400ZG16Bchr16

2881954

+PRH2chr12

11083493

+
In-frameENST00000572863ENST00000381847ZG16Bchr16

2881946

+PRH2chr12

11083485

+
In-frameENST00000572863ENST00000381847ZG16Bchr16

2881946

+PRH2chr12

11083536

+
In-frameENST00000572863ENST00000381847ZG16Bchr16

2881946

+PRH2chr12

11083629

+
In-frameENST00000572863ENST00000381847ZG16Bchr16

2881954

+PRH2chr12

11083493

+
In-frameENST00000572863ENST00000396400ZG16Bchr16

2881946

+PRH2chr12

11083485

+
In-frameENST00000572863ENST00000396400ZG16Bchr16

2881946

+PRH2chr12

11083536

+
In-frameENST00000572863ENST00000396400ZG16Bchr16

2881946

+PRH2chr12

11083629

+
In-frameENST00000572863ENST00000396400ZG16Bchr16

2881954

+PRH2chr12

11083493

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000572863ZG16Bchr162881946+ENST00000381847PRH2chr1211083485+84456656442128
ENST00000572863ZG16Bchr162881946+ENST00000396400PRH2chr1211083485+87656656442128
ENST00000572863ZG16Bchr162881946+ENST00000381847PRH2chr1211083536+79356656442128
ENST00000572863ZG16Bchr162881946+ENST00000396400PRH2chr1211083536+82556656442128
ENST00000572863ZG16Bchr162881946+ENST00000381847PRH2chr1211083629+70056656442128
ENST00000572863ZG16Bchr162881946+ENST00000396400PRH2chr1211083629+73256656442128
ENST00000572863ZG16Bchr162881954+ENST00000381847PRH2chr1211083493+82855854481389
ENST00000572863ZG16Bchr162881954+ENST00000396400PRH2chr1211083493+86055877355273

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000572863ENST00000381847ZG16Bchr162881946+PRH2chr1211083485+0.0040274710.9959726
ENST00000572863ENST00000396400ZG16Bchr162881946+PRH2chr1211083485+0.0058418520.99415815
ENST00000572863ENST00000381847ZG16Bchr162881946+PRH2chr1211083536+0.0055047930.9944952
ENST00000572863ENST00000396400ZG16Bchr162881946+PRH2chr1211083536+0.008376040.99162394
ENST00000572863ENST00000381847ZG16Bchr162881946+PRH2chr1211083629+0.0047265990.9952734
ENST00000572863ENST00000396400ZG16Bchr162881946+PRH2chr1211083629+0.0078241430.9921759
ENST00000572863ENST00000381847ZG16Bchr162881954+PRH2chr1211083493+0.0860061050.91399395
ENST00000572863ENST00000396400ZG16Bchr162881954+PRH2chr1211083493+0.11787670.8821233

Top

Fusion Genomic Features for ZG16B-PRH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZG16B-PRH2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:2881946/chr12:11083485)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRH2chr16:2881946chr12:11083485ENST000003818470317_460167.0RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium
TgenePRH2chr16:2881946chr12:11083485ENST000003964000417_460171.66666666666666RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium
TgenePRH2chr16:2881946chr12:11083536ENST000003818470317_460167.0RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium
TgenePRH2chr16:2881946chr12:11083536ENST000003964000417_460171.66666666666666RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium
TgenePRH2chr16:2881946chr12:11083629ENST000003818470317_460167.0RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium
TgenePRH2chr16:2881946chr12:11083629ENST000003964000417_460171.66666666666666RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium
TgenePRH2chr16:2881954chr12:11083493ENST000003818470317_460167.0RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium
TgenePRH2chr16:2881954chr12:11083493ENST000003964000417_460171.66666666666666RegionNote=Inhibits hydroxyapatite formation%2C binds to hydroxyapatite and calcium

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZG16Bchr16:2881946chr12:11083485ENST00000382280+1438_460209.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881946chr12:11083485ENST00000572863+1338_460179.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881946chr12:11083536ENST00000382280+1438_460209.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881946chr12:11083536ENST00000572863+1338_460179.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881946chr12:11083629ENST00000382280+1438_460209.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881946chr12:11083629ENST00000572863+1338_460179.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881954chr12:11083493ENST00000382280+1438_460209.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881954chr12:11083493ENST00000572863+1338_460179.0Compositional biasNote=Poly-Leu
HgeneZG16Bchr16:2881946chr12:11083485ENST00000382280+1453_1850209.0DomainJacalin-type lectin
HgeneZG16Bchr16:2881946chr12:11083485ENST00000572863+1353_1850179.0DomainJacalin-type lectin
HgeneZG16Bchr16:2881946chr12:11083536ENST00000382280+1453_1850209.0DomainJacalin-type lectin
HgeneZG16Bchr16:2881946chr12:11083536ENST00000572863+1353_1850179.0DomainJacalin-type lectin
HgeneZG16Bchr16:2881946chr12:11083629ENST00000382280+1453_1850209.0DomainJacalin-type lectin
HgeneZG16Bchr16:2881946chr12:11083629ENST00000572863+1353_1850179.0DomainJacalin-type lectin
HgeneZG16Bchr16:2881954chr12:11083493ENST00000382280+1453_1850209.0DomainJacalin-type lectin
HgeneZG16Bchr16:2881954chr12:11083493ENST00000572863+1353_1850179.0DomainJacalin-type lectin


Top

Fusion Gene Sequence for ZG16B-PRH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101193_101193_1_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083485_ENST00000381847_length(transcript)=844nt_BP=566nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGCAAGGACCGCTATTTCTATTTTGGGAAGCTTGATGGCCAGA
TCTCCTCTGCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTG
AATGGAATTATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGG
TATGGGGCCATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAA
TAAATAAAGGTTCTGCAGAATCAGTGAAGGACCACCCCAACAGGGAGGCCATCCCCGTCCTCCTCGAGGAAGGCCACAAGGACCACCCCA
ACAGGGAGGCCATCAGCAAGGTCCTCCCCCACCTCCTCCTGGAAAGCCCCAGGGACCACCTCCCCAAGGGGGCCGCCCACAAGGACCTCC
ACAGGGGCAGTCTCCTCAGTAATCTAGGATTCAATGATAGGTATGATTCCAGTTTATTATCCATCAAAGGCTCCAACTGCTACAGTTCTC

>101193_101193_1_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083485_ENST00000381847_length(amino acids)=128AA_BP=
MHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQ

--------------------------------------------------------------
>101193_101193_2_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083485_ENST00000396400_length(transcript)=876nt_BP=566nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGCAAGGACCGCTATTTCTATTTTGGGAAGCTTGATGGCCAGA
TCTCCTCTGCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTG
AATGGAATTATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGG
TATGGGGCCATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAA
TAAATAAAGGTTCTGCAGAATCAGTGAAGGACCACCCCAACAGGGAGGCCATCCCCGTCCTCCTCGAGGAAGGCCACAAGGACCACCCCA
ACAGGGAGGCCATCAGCAAGGTCCTCCCCCACCTCCTCCTGGAAAGCCCCAGGGACCACCTCCCCAAGGGGGCCGCCCACAAGGACCTCC
ACAGGGGCAGTCTCCTCAGTAATCTAGGATTCAATGATAGGAAGTGAATAAGAAGATGACAGTGTTTCAAATGCCTTGAAACATAATGTG

>101193_101193_2_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083485_ENST00000396400_length(amino acids)=128AA_BP=
MHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQ

--------------------------------------------------------------
>101193_101193_3_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083536_ENST00000381847_length(transcript)=793nt_BP=566nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGCAAGGACCGCTATTTCTATTTTGGGAAGCTTGATGGCCAGA
TCTCCTCTGCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTG
AATGGAATTATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGG
TATGGGGCCATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAA
TAAATAAAGGTTCTGCAGAATCAGTGAAGGACCACCCCAACAGGGAGGCCATCAGCAAGGTCCTCCCCCACCTCCTCCTGGAAAGCCCCA
GGGACCACCTCCCCAAGGGGGCCGCCCACAAGGACCTCCACAGGGGCAGTCTCCTCAGTAATCTAGGATTCAATGATAGGTATGATTCCA

>101193_101193_3_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083536_ENST00000381847_length(amino acids)=128AA_BP=
MHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQ

--------------------------------------------------------------
>101193_101193_4_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083536_ENST00000396400_length(transcript)=825nt_BP=566nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGCAAGGACCGCTATTTCTATTTTGGGAAGCTTGATGGCCAGA
TCTCCTCTGCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTG
AATGGAATTATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGG
TATGGGGCCATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAA
TAAATAAAGGTTCTGCAGAATCAGTGAAGGACCACCCCAACAGGGAGGCCATCAGCAAGGTCCTCCCCCACCTCCTCCTGGAAAGCCCCA
GGGACCACCTCCCCAAGGGGGCCGCCCACAAGGACCTCCACAGGGGCAGTCTCCTCAGTAATCTAGGATTCAATGATAGGAAGTGAATAA
GAAGATGACAGTGTTTCAAATGCCTTGAAACATAATGTGATCATGCTCTAACTTCAATATACCAATAAAATAATCAGCTTGCAATTTCTG

>101193_101193_4_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083536_ENST00000396400_length(amino acids)=128AA_BP=
MHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQ

--------------------------------------------------------------
>101193_101193_5_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083629_ENST00000381847_length(transcript)=700nt_BP=566nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGCAAGGACCGCTATTTCTATTTTGGGAAGCTTGATGGCCAGA
TCTCCTCTGCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTG
AATGGAATTATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGG
TATGGGGCCATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAA
TAAATAAAGGTTCTGCAGAATCAGTGAAGGACCTCCACAGGGGCAGTCTCCTCAGTAATCTAGGATTCAATGATAGGTATGATTCCAGTT

>101193_101193_5_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083629_ENST00000381847_length(amino acids)=128AA_BP=
MHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQ

--------------------------------------------------------------
>101193_101193_6_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083629_ENST00000396400_length(transcript)=732nt_BP=566nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGCAAGGACCGCTATTTCTATTTTGGGAAGCTTGATGGCCAGA
TCTCCTCTGCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTG
AATGGAATTATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGG
TATGGGGCCATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAA
TAAATAAAGGTTCTGCAGAATCAGTGAAGGACCTCCACAGGGGCAGTCTCCTCAGTAATCTAGGATTCAATGATAGGAAGTGAATAAGAA
GATGACAGTGTTTCAAATGCCTTGAAACATAATGTGATCATGCTCTAACTTCAATATACCAATAAAATAATCAGCTTGCAATTTCTGATT

>101193_101193_6_ZG16B-PRH2_ZG16B_chr16_2881946_ENST00000572863_PRH2_chr12_11083629_ENST00000396400_length(amino acids)=128AA_BP=
MHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQ

--------------------------------------------------------------
>101193_101193_7_ZG16B-PRH2_ZG16B_chr16_2881954_ENST00000572863_PRH2_chr12_11083493_ENST00000381847_length(transcript)=828nt_BP=558nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGGCTATTTCTATTTTGGGAAGCTTGATGGCCAGATCTCCTCT
GCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTGAATGGAAT
TATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGGTATGGGGC
CATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAATAAATAAA
GGTTCTGCAGAATCAGTGCCCCAACAGGGAGGCCATCCCCGTCCTCCTCGAGGAAGGCCACAAGGACCACCCCAACAGGGAGGCCATCAG
CAAGGTCCTCCCCCACCTCCTCCTGGAAAGCCCCAGGGACCACCTCCCCAAGGGGGCCGCCCACAAGGACCTCCACAGGGGCAGTCTCCT
CAGTAATCTAGGATTCAATGATAGGTATGATTCCAGTTTATTATCCATCAAAGGCTCCAACTGCTACAGTTCTCCAACTTCATTGTGCCA

>101193_101193_7_ZG16B-PRH2_ZG16B_chr16_2881954_ENST00000572863_PRH2_chr12_11083493_ENST00000381847_length(amino acids)=89AA_BP=5

--------------------------------------------------------------
>101193_101193_8_ZG16B-PRH2_ZG16B_chr16_2881954_ENST00000572863_PRH2_chr12_11083493_ENST00000396400_length(transcript)=860nt_BP=558nt
ACACTGGCCCTTGCTTTGGAGTCAGGAGGCCTCTCTTCTTCCCACAGAGCCCTGGGATGCACCGGCCAGAGGCCATGCTGCTGCTGCTCA
CGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACC
ATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGGCTATTTCTATTTTGGGAAGCTTGATGGCCAGATCTCCTCT
GCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTGAATGGAAT
TATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAGGGTGGGGTATGGGGC
CATCCGAGCTGAGGCCATCTGGGTGGTGGTGGCTGATGGTACTGGAGTAACTGAGTCGGGACGCTGAATCTGAATCCACCAATAAATAAA
GGTTCTGCAGAATCAGTGCCCCAACAGGGAGGCCATCCCCGTCCTCCTCGAGGAAGGCCACAAGGACCACCCCAACAGGGAGGCCATCAG
CAAGGTCCTCCCCCACCTCCTCCTGGAAAGCCCCAGGGACCACCTCCCCAAGGGGGCCGCCCACAAGGACCTCCACAGGGGCAGTCTCCT
CAGTAATCTAGGATTCAATGATAGGAAGTGAATAAGAAGATGACAGTGTTTCAAATGCCTTGAAACATAATGTGATCATGCTCTAACTTC

>101193_101193_8_ZG16B-PRH2_ZG16B_chr16_2881954_ENST00000572863_PRH2_chr12_11083493_ENST00000396400_length(amino acids)=73AA_BP=49

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZG16B-PRH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ZG16B-PRH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ZG16B-PRH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource