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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZGPAT-HELZ2 (FusionGDB2 ID:101198)

Fusion Gene Summary for ZGPAT-HELZ2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZGPAT-HELZ2
Fusion gene ID: 101198
HgeneTgene
Gene symbol

ZGPAT

HELZ2

Gene ID

84619

85441

Gene namezinc finger CCCH-type and G-patch domain containinghelicase with zinc finger 2
SynonymsGPATC6|GPATCH6|KIAA1847|ZC3H9|ZC3HDC9|ZIPPDIP-1|PRIC285
Cytomap

20q13.33

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH-type with G patch domain-containing proteing patch domain-containing protein 6zinc finger CCCH domain-containing protein 9zinc finger and G patch domain-containing proteinzinc finger, CCCH-type with G patch domainhelicase with zinc finger domain 2ATP-dependent helicase PRIC285PDIP1PPAR gamma DBD-interacting protein 1PPAR-alpha-interacting complex protein 285PPAR-gamma DNA-binding domain-interacting protein 1PPARG-DBD-interacting protein 1PPARgamma-DNA-bindi
Modification date2020031320200313
UniProtAcc.

Q9BYK8

Ensembl transtripts involved in fusion geneENST00000478385, ENST00000328969, 
ENST00000355969, ENST00000357119, 
ENST00000369967, ENST00000448100, 
ENST00000427522, ENST00000467148, 
ENST00000479540, 
Fusion gene scores* DoF score6 X 4 X 3=724 X 4 X 3=48
# samples 54
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZGPAT [Title/Abstract] AND HELZ2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZGPAT(62340516)-HELZ2(62190723), # samples:1
Anticipated loss of major functional domain due to fusion event.ZGPAT-HELZ2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZGPAT-HELZ2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZGPAT

GO:0000122

negative regulation of transcription by RNA polymerase II

19644445

HgeneZGPAT

GO:0007175

negative regulation of epidermal growth factor-activated receptor activity

19644445

HgeneZGPAT

GO:0045892

negative regulation of transcription, DNA-templated

19644445

TgeneHELZ2

GO:0045944

positive regulation of transcription by RNA polymerase II

16239304


check buttonFusion gene breakpoints across ZGPAT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HELZ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A105-01AZGPATchr20

62340516

+HELZ2chr20

62190723

-


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Fusion Gene ORF analysis for ZGPAT-HELZ2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000478385ENST00000427522ZGPATchr20

62340516

+HELZ2chr20

62190723

-
3UTR-3CDSENST00000478385ENST00000467148ZGPATchr20

62340516

+HELZ2chr20

62190723

-
3UTR-intronENST00000478385ENST00000479540ZGPATchr20

62340516

+HELZ2chr20

62190723

-
5CDS-intronENST00000328969ENST00000479540ZGPATchr20

62340516

+HELZ2chr20

62190723

-
5CDS-intronENST00000355969ENST00000479540ZGPATchr20

62340516

+HELZ2chr20

62190723

-
5CDS-intronENST00000357119ENST00000479540ZGPATchr20

62340516

+HELZ2chr20

62190723

-
5CDS-intronENST00000369967ENST00000479540ZGPATchr20

62340516

+HELZ2chr20

62190723

-
5CDS-intronENST00000448100ENST00000479540ZGPATchr20

62340516

+HELZ2chr20

62190723

-
Frame-shiftENST00000328969ENST00000427522ZGPATchr20

62340516

+HELZ2chr20

62190723

-
Frame-shiftENST00000355969ENST00000427522ZGPATchr20

62340516

+HELZ2chr20

62190723

-
Frame-shiftENST00000357119ENST00000427522ZGPATchr20

62340516

+HELZ2chr20

62190723

-
Frame-shiftENST00000369967ENST00000427522ZGPATchr20

62340516

+HELZ2chr20

62190723

-
Frame-shiftENST00000448100ENST00000427522ZGPATchr20

62340516

+HELZ2chr20

62190723

-
In-frameENST00000328969ENST00000467148ZGPATchr20

62340516

+HELZ2chr20

62190723

-
In-frameENST00000355969ENST00000467148ZGPATchr20

62340516

+HELZ2chr20

62190723

-
In-frameENST00000357119ENST00000467148ZGPATchr20

62340516

+HELZ2chr20

62190723

-
In-frameENST00000369967ENST00000467148ZGPATchr20

62340516

+HELZ2chr20

62190723

-
In-frameENST00000448100ENST00000467148ZGPATchr20

62340516

+HELZ2chr20

62190723

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448100ZGPATchr2062340516+ENST00000467148HELZ2chr2062190723-8767073746247
ENST00000355969ZGPATchr2062340516+ENST00000467148HELZ2chr2062190723-865696112735207
ENST00000357119ZGPATchr2062340516+ENST00000467148HELZ2chr2062190723-917748164787207
ENST00000369967ZGPATchr2062340516+ENST00000467148HELZ2chr2062190723-884715131754207
ENST00000328969ZGPATchr2062340516+ENST00000467148HELZ2chr2062190723-880711127750207

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448100ENST00000467148ZGPATchr2062340516+HELZ2chr2062190723-0.0025565640.99744344
ENST00000355969ENST00000467148ZGPATchr2062340516+HELZ2chr2062190723-0.0016213520.99837863
ENST00000357119ENST00000467148ZGPATchr2062340516+HELZ2chr2062190723-0.0018898370.9981102
ENST00000369967ENST00000467148ZGPATchr2062340516+HELZ2chr2062190723-0.001623990.998376
ENST00000328969ENST00000467148ZGPATchr2062340516+HELZ2chr2062190723-0.0016321840.99836785

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Fusion Genomic Features for ZGPAT-HELZ2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZGPAT-HELZ2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:62340516/chr20:62190723)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HELZ2

Q9BYK8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. {ECO:0000269|PubMed:16239304, ECO:0000269|PubMed:23525231}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZGPATchr20:62340516chr20:62190723ENST00000328969+27119_128194532.0Compositional biasNote=Poly-Glu
HgeneZGPATchr20:62340516chr20:62190723ENST00000355969+27119_128194512.0Compositional biasNote=Poly-Glu
HgeneZGPATchr20:62340516chr20:62190723ENST00000357119+27119_128194503.0Compositional biasNote=Poly-Glu
HgeneZGPATchr20:62340516chr20:62190723ENST00000369967+27119_128194512.0Compositional biasNote=Poly-Glu
HgeneZGPATchr20:62340516chr20:62190723ENST00000448100+27119_128194512.0Compositional biasNote=Poly-Glu
TgeneHELZ2chr20:62340516chr20:62190723ENST0000042752212142229_223320392081.0MotifNote=LXXLL motif 5
TgeneHELZ2chr20:62340516chr20:62190723ENST0000042752212142174_218120392081.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZGPATchr20:62340516chr20:62190723ENST00000328969+27333_379194532.0DomainG-patch
HgeneZGPATchr20:62340516chr20:62190723ENST00000355969+27333_379194512.0DomainG-patch
HgeneZGPATchr20:62340516chr20:62190723ENST00000357119+27333_379194503.0DomainG-patch
HgeneZGPATchr20:62340516chr20:62190723ENST00000369967+27333_379194512.0DomainG-patch
HgeneZGPATchr20:62340516chr20:62190723ENST00000448100+27333_379194512.0DomainG-patch
HgeneZGPATchr20:62340516chr20:62190723ENST00000328969+27175_201194532.0Zinc fingerC3H1-type
HgeneZGPATchr20:62340516chr20:62190723ENST00000355969+27175_201194512.0Zinc fingerC3H1-type
HgeneZGPATchr20:62340516chr20:62190723ENST00000357119+27175_201194503.0Zinc fingerC3H1-type
HgeneZGPATchr20:62340516chr20:62190723ENST00000369967+27175_201194512.0Zinc fingerC3H1-type
HgeneZGPATchr20:62340516chr20:62190723ENST00000448100+27175_201194512.0Zinc fingerC3H1-type
TgeneHELZ2chr20:62340516chr20:62190723ENST000004275221214968_105920392081.0Compositional biasNote=Ala-rich
TgeneHELZ2chr20:62340516chr20:62190723ENST000004671481719968_105926082650.0Compositional biasNote=Ala-rich
TgeneHELZ2chr20:62340516chr20:62190723ENST0000042752212141075_107920392081.0MotifNote=LXXLL motif 1
TgeneHELZ2chr20:62340516chr20:62190723ENST0000042752212141118_112220392081.0MotifNote=LXXLL motif 2
TgeneHELZ2chr20:62340516chr20:62190723ENST0000042752212141173_117720392081.0MotifNote=LXXLL motif 3
TgeneHELZ2chr20:62340516chr20:62190723ENST0000042752212142012_201620392081.0MotifNote=LXXLL motif 4
TgeneHELZ2chr20:62340516chr20:62190723ENST000004275221214667_67020392081.0MotifNote=DEAA box
TgeneHELZ2chr20:62340516chr20:62190723ENST0000046714817191075_107926082650.0MotifNote=LXXLL motif 1
TgeneHELZ2chr20:62340516chr20:62190723ENST0000046714817191118_112226082650.0MotifNote=LXXLL motif 2
TgeneHELZ2chr20:62340516chr20:62190723ENST0000046714817191173_117726082650.0MotifNote=LXXLL motif 3
TgeneHELZ2chr20:62340516chr20:62190723ENST0000046714817192012_201626082650.0MotifNote=LXXLL motif 4
TgeneHELZ2chr20:62340516chr20:62190723ENST0000046714817192229_223326082650.0MotifNote=LXXLL motif 5
TgeneHELZ2chr20:62340516chr20:62190723ENST000004671481719667_67026082650.0MotifNote=DEAA box
TgeneHELZ2chr20:62340516chr20:62190723ENST000004275221214544_55120392081.0Nucleotide bindingATP
TgeneHELZ2chr20:62340516chr20:62190723ENST0000046714817192174_218126082650.0Nucleotide bindingATP
TgeneHELZ2chr20:62340516chr20:62190723ENST000004671481719544_55126082650.0Nucleotide bindingATP
TgeneHELZ2chr20:62340516chr20:62190723ENST00000427522121440_6420392081.0Zinc fingerNote=C2H2-type%3B atypical
TgeneHELZ2chr20:62340516chr20:62190723ENST00000467148171940_6426082650.0Zinc fingerNote=C2H2-type%3B atypical


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Fusion Gene Sequence for ZGPAT-HELZ2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101198_101198_1_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000328969_HELZ2_chr20_62190723_ENST00000467148_length(transcript)=880nt_BP=711nt
GAAAAGGGGGCGCCGGGCCGCTCTAGCCGGTGAGGCCGGCGGGCTCTCTGTGGCTGCGGCTGGGAAACCGCGCGGAGGAGGTGCCCGGCC
GGGGACCAGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCA
GCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGA
GCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGA
GTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGA
GGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTA
CTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCT
TTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACC
TCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCT

>101198_101198_1_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000328969_HELZ2_chr20_62190723_ENST00000467148_length(amino acids)=207AA_BP=
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV
EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC

--------------------------------------------------------------
>101198_101198_2_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000355969_HELZ2_chr20_62190723_ENST00000467148_length(transcript)=865nt_BP=696nt
AAGCACTTCCGGAAGCGGCGGCGCTCGGGAGGAAGTGCCGATCGGCTGCTGGGGCGAAAAGGGGGCGCCGGGCCGCTCTAGCCGCCCTGG
TCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGC
CTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAG
CCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCG
GGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATC
TGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGG
CACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCAC
TCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCT
GCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCTGCAGGAGGCCAACTA

>101198_101198_2_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000355969_HELZ2_chr20_62190723_ENST00000467148_length(amino acids)=207AA_BP=
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV
EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC

--------------------------------------------------------------
>101198_101198_3_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000357119_HELZ2_chr20_62190723_ENST00000467148_length(transcript)=917nt_BP=748nt
CGGCGCTCGGGAGGAAGTGCCGATCGGCTGCTGGGGCGAAAAGGGGGCGCCGGGCCGCTCTAGCCGGTGAGGCCGGCGGGCTCTCTGTGG
CTGCGGCTGGGAAACCGCGCGGAGGAGGTGCCCGGCCGGGGACCAGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCC
TGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACC
TGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGC
TGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGG
CCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACG
AGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGG
AAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGG
GAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCT
CAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCTGCAGGAGGCCAACTATGCCTTCCTGAAGAGCCCTCTCCACCTGCAAGGTGCCA

>101198_101198_3_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000357119_HELZ2_chr20_62190723_ENST00000467148_length(amino acids)=207AA_BP=
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV
EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC

--------------------------------------------------------------
>101198_101198_4_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000369967_HELZ2_chr20_62190723_ENST00000467148_length(transcript)=884nt_BP=715nt
GGGCGAAAAGGGGGCGCCGGGCCGCTCTAGCCGGTGAGGCCGGCGGGCTCTCTGTGGCTGCGGCTGGGAAACCGCGCGGAGGAGGTGCCC
GGCCGGGGACCAGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGC
TGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCA
TCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATG
CTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAG
CAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGC
CCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTG
TGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGAC
CACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGC

>101198_101198_4_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000369967_HELZ2_chr20_62190723_ENST00000467148_length(amino acids)=207AA_BP=
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV
EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC

--------------------------------------------------------------
>101198_101198_5_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000448100_HELZ2_chr20_62190723_ENST00000467148_length(transcript)=876nt_BP=707nt
CGCCTGGGCCACGGCACCCTCGAGCGCCAGCCCCGCGCCCCACCCGGGAGCAGCGAGCCACCGGCGCGCTCCCCAGGAGCCCCTGCAGGC
GCCGGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAG
GTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTC
ACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTAC
CAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCG
GGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTAC
AGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTAC
CTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCT
TCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCTGCAG

>101198_101198_5_ZGPAT-HELZ2_ZGPAT_chr20_62340516_ENST00000448100_HELZ2_chr20_62190723_ENST00000467148_length(amino acids)=247AA_BP=
MGHGTLERQPRAPPGSSEPPARSPGAPAGAGPGPAPPSLSMDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELT
EASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAVEAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYS

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Fusion Gene PPI Analysis for ZGPAT-HELZ2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHELZ2chr20:62340516chr20:62190723ENST0000042752212142135_26492039.33333333333332081.0THRAP3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHELZ2chr20:62340516chr20:62190723ENST000004275221214563_10592039.33333333333332081.0THRAP3
TgeneHELZ2chr20:62340516chr20:62190723ENST0000046714817192135_26492608.33333333333352650.0THRAP3
TgeneHELZ2chr20:62340516chr20:62190723ENST000004671481719563_10592608.33333333333352650.0THRAP3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZGPAT-HELZ2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZGPAT-HELZ2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource