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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRAF-CUX1 (FusionGDB2 ID:10121)

Fusion Gene Summary for BRAF-CUX1

check button Fusion gene summary
Fusion gene informationFusion gene name: BRAF-CUX1
Fusion gene ID: 10121
HgeneTgene
Gene symbol

BRAF

CUX1

Gene ID

673

1523

Gene nameB-Raf proto-oncogene, serine/threonine kinasecut like homeobox 1
SynonymsB-RAF1|B-raf|BRAF1|NS7|RAFB1CASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75
Cytomap

7q34

7q22.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene protein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317
Modification date2020032920200320
UniProtAcc

P15056

P39880

Ensembl transtripts involved in fusion geneENST00000288602, ENST00000560541, 
ENST00000292535, ENST00000292538, 
ENST00000360264, ENST00000393824, 
ENST00000425244, ENST00000437600, 
ENST00000546411, ENST00000547394, 
ENST00000549414, ENST00000550008, 
ENST00000556210, 
Fusion gene scores* DoF score28 X 21 X 11=646826 X 23 X 9=5382
# samples 3229
** MAII scorelog2(32/6468*10)=-4.3371758685863
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(29/5382*10)=-4.21401758562548
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRAF [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRAF(140500162)-CUX1(101801840), # samples:1
CUX1(101758553)-BRAF(140494267), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

HgeneBRAF

GO:0006468

protein phosphorylation

17563371

HgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

HgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

HgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

HgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

HgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check buttonFusion gene breakpoints across BRAF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CUX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-F2-A44H-01ABRAFchr7

140500162

-CUX1chr7

101801840

+


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Fusion Gene ORF analysis for BRAF-CUX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000288602ENST00000560541BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000292535BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000292538BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000360264BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000393824BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000425244BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000437600BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000546411BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000547394BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000549414BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000550008BRAFchr7

140500162

-CUX1chr7

101801840

+
In-frameENST00000288602ENST00000556210BRAFchr7

140500162

-CUX1chr7

101801840

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000288602BRAFchr7140500162-ENST00000437600CUX1chr7101801840+32321041612364767
ENST00000288602BRAFchr7140500162-ENST00000292538CUX1chr7101801840+32381041612370769
ENST00000288602BRAFchr7140500162-ENST00000393824CUX1chr7101801840+27531041612364767
ENST00000288602BRAFchr7140500162-ENST00000547394CUX1chr7101801840+32381041612370769
ENST00000288602BRAFchr7140500162-ENST00000360264CUX1chr7101801840+1407610416148841607
ENST00000288602BRAFchr7140500162-ENST00000425244CUX1chr7101801840+32381041612370769
ENST00000288602BRAFchr7140500162-ENST00000292535CUX1chr7101801840+1407610416148841607
ENST00000288602BRAFchr7140500162-ENST00000549414CUX1chr7101801840+481910416148181586
ENST00000288602BRAFchr7140500162-ENST00000556210CUX1chr7101801840+441110416144101450
ENST00000288602BRAFchr7140500162-ENST00000550008CUX1chr7101801840+471710416147161552
ENST00000288602BRAFchr7140500162-ENST00000546411CUX1chr7101801840+457910416145781506

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288602ENST00000437600BRAFchr7140500162-CUX1chr7101801840+0.0089541970.9910458
ENST00000288602ENST00000292538BRAFchr7140500162-CUX1chr7101801840+0.0094900560.9905099
ENST00000288602ENST00000393824BRAFchr7140500162-CUX1chr7101801840+0.008244290.9917557
ENST00000288602ENST00000547394BRAFchr7140500162-CUX1chr7101801840+0.0094900560.9905099
ENST00000288602ENST00000360264BRAFchr7140500162-CUX1chr7101801840+0.0002019180.9997981
ENST00000288602ENST00000425244BRAFchr7140500162-CUX1chr7101801840+0.0094900560.9905099
ENST00000288602ENST00000292535BRAFchr7140500162-CUX1chr7101801840+0.0002019180.9997981
ENST00000288602ENST00000549414BRAFchr7140500162-CUX1chr7101801840+0.0046696350.99533033
ENST00000288602ENST00000556210BRAFchr7140500162-CUX1chr7101801840+0.0045344350.9954656
ENST00000288602ENST00000550008BRAFchr7140500162-CUX1chr7101801840+0.004105320.9958947
ENST00000288602ENST00000546411BRAFchr7140500162-CUX1chr7101801840+0.0042252960.9957747

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Fusion Genomic Features for BRAF-CUX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BRAFchr7140500161-CUX1chr7101801839+1.13E-060.9999989
BRAFchr7140500161-CUX1chr7101801839+1.13E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BRAF-CUX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140500162/chr7:101801840)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRAF

P15056

CUX1

P39880

FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140500162chr7:101801840ENST00000288602-718122_129326767.0Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140500162chr7:101801840ENST00000288602-7186_11326767.0Compositional biasNote=Poly-Gly
HgeneBRAFchr7:140500162chr7:101801840ENST00000288602-718155_227326767.0DomainRBD
HgeneBRAFchr7:140500162chr7:101801840ENST00000288602-718234_280326767.0Zinc fingerPhorbol-ester/DAG-type
TgeneCUX1chr7:140500162chr7:101801840ENST00000292538723502_556235679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST00000393824622502_556198640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST00000437600723502_556235677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST00000547394622502_556219663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST000002925357241406_14382241506.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:140500162chr7:101801840ENST000003602647241406_14382351517.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:140500162chr7:101801840ENST000004252446221406_1438189633.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:140500162chr7:101801840ENST000005464117241406_14382241404.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:140500162chr7:101801840ENST000005494147231406_14382241484.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:140500162chr7:101801840ENST000005500087221406_14382241450.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:140500162chr7:101801840ENST000005562107221406_14382241348.0Compositional biasNote=Ala-rich
TgeneCUX1chr7:140500162chr7:101801840ENST000002925357241117_12042241506.0DNA bindingCUT 3
TgeneCUX1chr7:140500162chr7:101801840ENST000002925357241244_13032241506.0DNA bindingHomeobox
TgeneCUX1chr7:140500162chr7:101801840ENST00000292535724542_6292241506.0DNA bindingCUT 1
TgeneCUX1chr7:140500162chr7:101801840ENST00000292535724934_10212241506.0DNA bindingCUT 2
TgeneCUX1chr7:140500162chr7:101801840ENST000003602647241117_12042351517.0DNA bindingCUT 3
TgeneCUX1chr7:140500162chr7:101801840ENST000003602647241244_13032351517.0DNA bindingHomeobox
TgeneCUX1chr7:140500162chr7:101801840ENST00000360264724542_6292351517.0DNA bindingCUT 1
TgeneCUX1chr7:140500162chr7:101801840ENST00000360264724934_10212351517.0DNA bindingCUT 2
TgeneCUX1chr7:140500162chr7:101801840ENST000004252446221117_1204189633.0DNA bindingCUT 3
TgeneCUX1chr7:140500162chr7:101801840ENST000004252446221244_1303189633.0DNA bindingHomeobox
TgeneCUX1chr7:140500162chr7:101801840ENST00000425244622542_629189633.0DNA bindingCUT 1
TgeneCUX1chr7:140500162chr7:101801840ENST00000425244622934_1021189633.0DNA bindingCUT 2
TgeneCUX1chr7:140500162chr7:101801840ENST000005464117241117_12042241404.0DNA bindingCUT 3
TgeneCUX1chr7:140500162chr7:101801840ENST000005464117241244_13032241404.0DNA bindingHomeobox
TgeneCUX1chr7:140500162chr7:101801840ENST00000546411724542_6292241404.0DNA bindingCUT 1
TgeneCUX1chr7:140500162chr7:101801840ENST00000546411724934_10212241404.0DNA bindingCUT 2
TgeneCUX1chr7:140500162chr7:101801840ENST000005494147231117_12042241484.0DNA bindingCUT 3
TgeneCUX1chr7:140500162chr7:101801840ENST000005494147231244_13032241484.0DNA bindingHomeobox
TgeneCUX1chr7:140500162chr7:101801840ENST00000549414723542_6292241484.0DNA bindingCUT 1
TgeneCUX1chr7:140500162chr7:101801840ENST00000549414723934_10212241484.0DNA bindingCUT 2
TgeneCUX1chr7:140500162chr7:101801840ENST000005500087221117_12042241450.0DNA bindingCUT 3
TgeneCUX1chr7:140500162chr7:101801840ENST000005500087221244_13032241450.0DNA bindingHomeobox
TgeneCUX1chr7:140500162chr7:101801840ENST00000550008722542_6292241450.0DNA bindingCUT 1
TgeneCUX1chr7:140500162chr7:101801840ENST00000550008722934_10212241450.0DNA bindingCUT 2
TgeneCUX1chr7:140500162chr7:101801840ENST000005562107221117_12042241348.0DNA bindingCUT 3
TgeneCUX1chr7:140500162chr7:101801840ENST000005562107221244_13032241348.0DNA bindingHomeobox
TgeneCUX1chr7:140500162chr7:101801840ENST00000556210722542_6292241348.0DNA bindingCUT 1
TgeneCUX1chr7:140500162chr7:101801840ENST00000556210722934_10212241348.0DNA bindingCUT 2
TgeneCUX1chr7:140500162chr7:101801840ENST00000292538723641_678235679.0Topological domainLumenal
TgeneCUX1chr7:140500162chr7:101801840ENST00000393824622641_678198640.0Topological domainLumenal
TgeneCUX1chr7:140500162chr7:101801840ENST00000437600723641_678235677.0Topological domainLumenal
TgeneCUX1chr7:140500162chr7:101801840ENST00000547394622641_678219663.0Topological domainLumenal
TgeneCUX1chr7:140500162chr7:101801840ENST00000292538723620_640235679.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr7:140500162chr7:101801840ENST00000393824622620_640198640.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr7:140500162chr7:101801840ENST00000437600723620_640235677.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr7:140500162chr7:101801840ENST00000547394622620_640219663.0TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140500162chr7:101801840ENST00000288602-718428_432326767.0Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140500162chr7:101801840ENST00000288602-718457_717326767.0DomainProtein kinase
HgeneBRAFchr7:140500162chr7:101801840ENST00000288602-718463_471326767.0Nucleotide bindingATP
TgeneCUX1chr7:140500162chr7:101801840ENST0000029253572456_4072241506.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000029253872367_450235679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000036026472456_4072351517.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000039382462267_450198640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000042524462256_407189633.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000043760072367_450235677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000054641172456_4072241404.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000054739462267_450219663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000054941472356_4072241484.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000055000872256_4072241450.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST0000055621072256_4072241348.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr7:140500162chr7:101801840ENST000002925387231_619235679.0Topological domainCytoplasmic
TgeneCUX1chr7:140500162chr7:101801840ENST000003938246221_619198640.0Topological domainCytoplasmic
TgeneCUX1chr7:140500162chr7:101801840ENST000004376007231_619235677.0Topological domainCytoplasmic
TgeneCUX1chr7:140500162chr7:101801840ENST000005473946221_619219663.0Topological domainCytoplasmic


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Fusion Gene Sequence for BRAF-CUX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10121_10121_1_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292535_length(transcript)=14076nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC
TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC
ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT
TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC
AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA
GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA
TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA
ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG
CAGACAAAGAGAGAATCCAGGCCAGAGCCTGAACAGACTATTTCAGGAAGTACCGAAACGAAGAAATGGGTCTGAAGGTAACATCACCAC
CCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGCCATCAAGTCCATCCTAGAGCAAGCCAAGAGGGAGCTCCAAGTGCAGAAAACTGC
AGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGA
GGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCAC
CTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCT
GCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAG
ACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTC
CGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAG
TCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGAC
CGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCC
CCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAA
GAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATG
GAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCA
GGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAA
GACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTG
TCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCT
CTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGT
GCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCC
CAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCT
GATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGT
CGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGC
GCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGT
CATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGC
CAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGG
CAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTC
GGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGC
GACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGC
GCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGC
CCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGCCGCCAGCCGGGA
GGAACCTATCGAATGGGAGTTCTGAGGGGCCGCGGCCCTGGGGCGGGCAGCCAGGCTGGGCCGCAAGGGCCTGGACGGGGTCGGACGGGG
CAGGCGCTGCGGACACCGTGGCCTGGGCTTGGCCCGCGGCCTGCACCGACCCCGGGCCGGACCTGAGCCCGCAGCCCAGACCCCCTCCAC
GGTCCGCGGCCTGCACCGACCCGAGGCCCAGATCCAAGGCCGCGGCCCAGACCCACTCTGCGGCCCGGGCCGACCCTGCGGCCTCCACCA
ACCCCGCGGCCCAGACCCAGCCCGCGGCCTGGACCCCTGGACCGCTTTGCGCACTTACCGCCCTGCGGGCCACAGGGCAAAATCGCCATA
GGCCAAGGTGCATATAGAAAACAAAGGAGCATTAAGCCCAATCTATGTCGTGTTTTCAAGGAAGAAAACGGAAATGTGTGGTCGAGCTTT
TTTGTACCCTGAAGTGTTTTTTTTATTGCCCTAAGTGATTTCCACAGGTTCTGGAATAACTCTTACAGCTTTGCCTTGTGTCCTCCTGTT
CCGTGTGGGCTTTAAAAGAAAAAAAATCAAACCCACATATTAAAAGGGGGCTTTTTATCTGCCATCTAATGGCTTCAGAGCGATAATACA
CTATTATCTTCTTAAACCAGGAAAAAATAAAAGGGGGGGTGGGATTTTTCAGAAAAATTAAAAAAGAAAGTTTTTGTAGCTGTTCAGTTG
CCACTAAGAGATTGCACAGTCAAAACGACTCTAAACACACTAGTTTGGATTCCTAAATATTTTCAAGAAAAGAATCTTCTCGTTTGAAAC
TTTGAATTAAAATAAAACACATTTACTCCACATATTTTTTAACAAAAAGAAAACGTCACATCAGGAAACTCTGATTTTGTGGTAGCTGAC
ATAGTGTTTTCTTGTACGTGAATAGAATCCTGACATGTAGTGCACATTGATGTATAGCTTTAACTGACCCTGGGTTTTGCAGACCAGGGT
TTGTTTAATACACTCCATTCTAGGCCAAATCAGGACAAAAAAAAGAAAAAAAAAGAAAAAAAAAAAAGAAAAGATCCGAATCTAGGTATT
TTATAATCTGCTTTTTAACCTCTAACCGCAGAGCACGCTGATCAGACCTCATATCTTGGAGGTTTAGGAGACAAGTTAGAACTGTAGCAT
GTACCTGTTAATTTTGTTTAATTTATGGTGTCTCAATCTGTCTGTGCGTCTGCACGTGTGCAAGCATTGAAAGAAAGGAGAGAGTAGTCC
GGGCGAGCACAGCAGGCAGTTCCAGGGCCAGACGGGCCCATCCCCAAGTAGATAGCAGTCTACGGATCTCTCTCTGGCACAGAAGGCACC
TCACCTCACACCACTCTCCTGGATACCTGATGAACTGAGCCCTCCCAGGGGAAGACACTCCCCAGGCCTGGGCAGGGCTTACACGCGCAC
TCTCTCTCTTCTTTCCCTTTTTCTTCCCACCGCAAGCACTGATGACCCTGTTGAACTCGTGGGAAACTTCCTTTCTCTGCAGGAGAGAGA
ACGTGGCATTCTGGGCTCCCCACTCCCATCCCTGTAGAAATGGCCCAAACTCACACCAAAACGTGGATGCTCTTCAACTTCCAAACCTAC
CATTTGCCCTTCTTTCATTTCGCCTCTTAGTTCTTTTTATGCACAGTTTTAGGGCAGTCTAAGTACAAACTGAAAGTCTAACTTGTCTCT
GATTCCTCCCTTGTCTATGTGTATATGCGTGAGAATAGAGGCGGGTGAGAGTGTGCGTGCGTGTGCGTGTGTGCAATTTTATACGTCTGT
GTATTTTCTTAAGTACCTGTGCACACGTAGAGTGCATTACTGCCACCTTTTTCAATAAGCTGTTTTATCAGTTACGGCTTCTACAAGTTT
GCTAATTTAGACTTCTTTATTGCCATATCTTTAAACTAACAATAGATGATTTCGGTATATATATATATTTTTTTTTGCTTATTTATAGGT
GCTGTATTTTATTATCTGATTGTTAGGAAGGGATGAAAGGGGCAAATATTCTTTAGAGGGATAGACTGCCGGCAGTATTGGGTATAATTT
ACAAGATGTAGTTGTCATACTGTATATTACTGATTGAAAACTTTTTGACCGTATTGTGTATCATTGAAACCTTTGTCTTAGGTCAACATC
TTTGGATGACATTTTAATGGTGCATTCATTATTTCTTAAGTTTAATTAATATTACTTTTTTTTTTATTTGGGGGGTGGGAGGGAGTTATA
ATTTTAAAGGTATGCTCTGGCTGTTCCACCTCCGTGTGCTTGTTAATTAACTTGTAGGACTTTGACTGTAAGATGTGAAACCACGTTTCT
TGCATGATGTTTTAGAGATTATTTCATTTACAGTCTTTTAACCTGCAGCTGCAGCACTTAGTTCACGTTTTCACAAATTTCAAGAGTCAC
TACACTAAAGACAATGCCTTTTCATGAATAAGAAGTTTTCAGAAGGCTCTAGGGGGCTGGGAGGCAGGCTGTTCGTTTGTCTTTTGTTGG
GGGTATCATTTCTGAACTTGAAATCCAGTTCAGGGAGAAGAGAATTCAAAATTAGAGGAGCTTAAGGGGACACGGGTCAACATCTAGCTC
GATTCAGGTGCATTGAGAAGAGTGAGTTCACATCGGTGACCCTTAGGACAGTGAGTGGCAGAGCCCTGACGACTGTGGTGTCCTCTCCAC
AAAACCCTCAAGGGACTTTTGTCATCATGTGTGATGAATCTTTAAATATCGTCTAATTTTCATAAGAATGAAAAGAAGTTAACAGGAAAT
AGTAGGCTAGGGTTTAGTTTTAAAGGCATGACTGTTATTTACAAAGGTGTTAAATCTGAGGAAATTGACAAATACAGATTTGTCCATTCT
AGTGGCCAAACAGTAACAGTCTAAAATGCAGTCATTTTGACCCTCCCAAGCAATTTAGTCATATGTGTTGTTTTCTCTTTTCTGTTTTTA
CTTCTTAGATTTTTAACTAGGTTACTGTTGGTTCCCATTCTGTCTTTTTTGCCAGACTTACATCTGGTGCCAGATACAATCAGTTGGTTA
AATTTTGCTTGCAGTTCTGTGTATTTTTTTTCCTCTATTATTTATTTTTTTAAAAAAAATAGAGATCCTAACCTTAGATCTTTGATGTGA
AGCTAGCACTGTCTGTAATACTTCTAAGAGCTGCCACTAAAATAATACAGCAATCCGTGGCCAGGGGAGCACCCCCTCCTGGTTGGGCCC
CTCAGTTGGAGTCTAAGGGTTAATCTCTCATCTTGCTAAGCAGTATTCAAGTGCCTTGAACAGTGTCCCCTCGGCATGGCTCCCCTTCAG
CAGGCTGGCATTCCAAGCAGTGGCCCCCGCAGGCAGCCGACCCCCTTCCTCTTCACGCTCTATGAGTTTAAAAAGCTGATTTGTACCTCT
CCCCTGGGGGAAACGGTTCCATATAAAACACTAACACTTAATTACAAGCTCCATTATGCCATTTTAAATGGCTTCTTTTTGTTAATTGGA
GGCATTGTTCATAACTTAAGGCTTTTGCCATTAACTTAGCTGGCTAAGCAGAGGCTCGGGGTAAAATCAGTGTTTGCATTTAGCCTCTTG
ACCCGGAGTTCCGGCCCAAGCTCCCTTGTGATAGCCGAGATGGCAGGTGTGTGAGTTCTGTCCTAGACCTGTGCCCAACTCACTTCCACC
CCAGAGGAGTCTTCTGTCCTCCTCCCCAACCCCCGAGCTCCCTGGTAACCTCCTCTTGAACTTCTGTATCAGTGAAGACATCTGTGGTTT
CTGCTCACCAGACCTCTCTTTAGAAAGGGTTATCAGAGCCATGGAGCTTAGCTCAATTGGATTCTTCTAGACGATCTTAGGAGGCATCTT
GGCATGAGGCAGCTTCTAAGCGTCTCCTGGGACAGGATTGGGGTGACAGCCCAGGGATGCATGCATGGGAGAACTCTCTGAGAAATGCCA
GGATCGTGGCTCACAGGGACCCACCATCAAAACCTGCTACTTTGTGCAAGTAATTGAGGCAAAAGATACCAGTCGACAGCCTCCCTGGGG
TAGATCCCTTGTACCTCCAAAGTACAAATACCTCCCTGCTCAGTTTCCTTCCTGTCGCCATCTTTGTTTTCTTCCCATTGAAAAACCATC
CTGTCTGATGTGGACGTTCAGGTCTGCTGGTTGGCGGTCCGGGCCCAGAGTGCAGCAGAGCTCTGGGTTAAATATTCCTTTCTGGCCACC
GCCCAAGCCCAGGTGGCCAGCTCTCATACCCCATCTCCCTCCTTGGCCAGGGCCAGCATCAGGCGTGCAGCTCATGACCAGTTTACACAG
GCTGCAAAGAGATCGCTGTGGGCCTCGGCTGACTACTTTAAGATTATGCCACAGCCAGGCCCTAAAAAGAGAGGGGAACAGGAGTCCCCA
GGTGAGCTCTCTGACGGGCAGGTGCCTTCCCGACTAAGGTTGGACTGGATGACTTTGTTCCTCCTGCATGCATGTCCTTTGATGCAAGGG
TGATCAATGAACTCTGTTGACATTCTATGCAATGTTTTTCATTCCTCTGATTTTAGCAAAGCAAATCTTACTGAAAAATAGCAGAGCCAG
GGGAACAGACGCATGTCCTTCTGGGAGTCACACAAAAGCAGAGAGATTTTGAACTGAGGGGCGACAGCCTTTGCCTTAAATGCAGTATGA
CAGGCGCTTCTTGGCAGACCAGTAAAAACAAAAGCCCATAGACCTTACTCATCCCAAGGCCGACAAGCCAGCTGTACAGGGCGAGATGTA
GCAACACGGGGCATGAGCGGTGGGCGTGCTGGGCTATTTGCTGTGGTACTTTAGGCTGGAGGTTTGGCTCCTGTGCTGCCGGTGGGGGGC
CCTGTCCCTCCCCAGATGTCCTCCCTCTTCTTCACACTCCTCATTGTCCCTTCTACCTCACTAACCTGTCTTCTCCATCTGATGTCACCC
AGAACCACACCCCACAGAACTGTGAGGCACGTGGGCTGGAGAGAGCAGAAAAGCTGCCAGCGCAGCAGACACGAACATCCCTCTGCCTGG
TGGGCCGGCTTTGTGTGTCTCTCCTTTTGTGAGCGCAACACGGACAAACAGCTGTGCTCTGCAAGGCACACGGATGTTTCCCTTCCACCT
GTTCCCAAAGCTCCAGCAGCTGTTTCTTTTGCAGGCAGGGCGTGGTCTCGGGGCTCCGAGGGTCTTGTCTTTGGTCCGCCTTCCTTTCTG
TCCAGTCCTGCTCAGCTGTTAAGATCCATCATGGCCATTATCCTTGTCCCGGACTGCCCCAAAGTTCCCAGCTGGCTTTGGGGAACACTG
TAGCTCTTGGGTGTCTCTTGTCTCTGGCATGGTTTTAGCGTCACTGCGAACACTCCTTTGCAAACATCAAACATCTCAAAGACGGAAAAG
GATAGATGGCTTCCTCCAGCCTACACGCCCCGTCCACAGTGGCATCACCCTCTTATCCCAAAAGAATATGCCAGTTCCCATCCAGCACCG
AAGAAAATCAGCTCCTGGGGCTGGTGGTTGGAGGTGGGTCTGTCCACTGTGGGGGCCAAAGTGTTCCCCTGCTGGAGACAGTTTGCAAGT
AAGAACCTAAGGATGGGGACAGCATCCTGTGCTTGGGCATTGACCAGCCAAAGCTCACATTTAGAAAGCCCTCAGTGCTTCTGTGGTTTC
ACCTGGGCATCGACGACATTAGGGAAGCCTTTGTGACCACAAGGGCAGGGCTTGTGCCCTGAGTGGCGAGGTGGTGACCTGAGGCCAGTG
TGATGTGGTTGGATCTCAGCGTGTACTGAATGCCAGTCTGGCCGGCACACTCGAACGCTAAGAGAATGGTCCAATTTGATGATCTTATTT
CTATTTCGATCAGGTTTTGACTTTTTGTAGATGAAAACTACCAGGGAAAAGGGGAAGCAGGTACCCAATAAAGTTTAGAAAGATCCAGTC
TGTGAAACCCTTAGAGATGGGCTGAAAGTTAAGTCCACCAACCCTTGGGCTTAATCAGGACGGAAGAGGAGGGGGTGTGGGGGGCAGAGC
GTAAAACAAGCCCCAGCCCTACTCCCGGCCCCCCAGCCCAGTCTTCCCAATCCCAGAGGCCCCGGCGGCCTGTGCTCCTCACCACCCTGG
TCAGGGGAATAGAAGGAAATGCAATTTCCGCCTGTCTGCCCGACTTCCAAAAACTGCCTCCTCCTGCCCAGGCCTCTCCCACCACCACCT
TCCCTCCAAAGATAACCGTGTCCATGCCATCCGTGGCATCATCTCGAGTTTTCATTTTTGGATGAAGTGACATTTAGCTTTAACAAGACA
TTTCCAAAGCGCCTAGTCTCCTCCAAAATGCTAACTTTAAAAGTTGGGCATTGTAGGCGAAAAATCCCAAAAAAAAAAAAAGACAAAAAA
AAAAGGCTGGCGAGAGAAAGACATTTGGCTATGCATAAATGTGCACTTCCCCCATGCCCCCGTTCTTAAACTCTTAAGATGCCTTTGAGT
TGCTTTTCATGAATCCTTTTAGTTTACCCGATAATGTTAAGAAAGCATTAGTCTACGTTACTGTAATTTCTGTAGTGTTTACGCTTTAAT
TTCTACCACAAAATATGCTATATGCTATGTATCAAGCTTTCTGTAATCAGAAAGAAAAGGTGCCTTATATCCCAATGTCACGGCTACATC
CCTATGGAAATTAATCAGAAGCACAGTGTGTACGGAAGCATTGGGACTTCTGCTGGTGAAACAAGAGACCATTCAGCAAGACACATTGAA
GTGGCACGGAGCTGCTTTTGTTTTATAATTCTTTTTTCCCCCCTTTTCCTTCTTCTTTTTTATTATTTTATTATTTTTTTTGTACTTTGC
TTTAAACGGAAAGCACTTAAATAGATGACTATGTGTAAAAGCTCTGTGCAATTGAAATCATTTTTCTTCATTTTAAAAAAATAACGTATT
GCACACCAAATGAACTCAAAGTAAGCTTTAGACCAGGACGATTCAGGTTATGAATGAGTTTGTTCACTGTAGTTCCGTTTGTTCATGAAC
CGAAGGGAAAACAGGCCTCCCCGACTCCCTCCAGTCTCCCAGCCTGCCTCTTGGTGACCACTGTGCTGGGCGTGCAGGGCCCGCGGGCTC
TGGCCGGAGCCGCTGGCCTGACGAGGCAGGATAGGGAGTATCCGTGATTCAGAAGCTGAGACCCTTCCCCAGTGTCTGAGGCCACAGCCA
TCCCTTCCAGCACTTAATCTTGTCTTGTTGAAATGGACTGACTGCTACTGACCTGCCGGCGTGCGTGAGGGTGATTATAAAAGGATGTTT
CCTTGAGAAAAAAAAAATTATTTCTATCCTCTTCTATTTATTATTAGGTTAATCATTTAAGTACTTATCAGGAGTGTATTGTTATTTTGT
GTTTTGTTGTCATAAATGCTTTTTGCTGTCACTCTAGTGGTTACTATCCTCTGCCTTCCTCTCCTCCCCTACTCCCCCAGAGAACCAAGG
CGTCTGGGGGATTGACTGGGGGGCAGAGGGGGTTTCCCCAGCAAAATCAAACACCTGTCTCCAGAGTAGCCACTCAAAAACTGGTGGTCT
CTATGTGTCTAACTTTTTAAATGAGAGTGTTTATGAACAAAAAAATTTACCAACGTGTGAGGGAGTTGCTGAGTTGAAGAATGCTCGCTT
GAGGAGCTTCAGAGGAATCTTAGCAAAGCCAAGTTCAGTTCCCCAAAGCCTCCTAGAGCCTCTGGTAAGACTTCTGGGTTCATGAAGTTT
CGGCGAGCCGTGGTCAGAGAGGGCGCGGTGGCCTGGCCAAGACTTTACCTCCAAGCGAGAGAGTGATTTCTTGCAAGGCCCGCATGGGTT
GATACGTTTTGGTTGGTTTTTTGTTGTTGTTTTTCTTGCGTACAAAGTTGGTCAAAACCATCTTTCAAAGCAACAGTGTTTTGTAGTACC
AGGCTGTGGCTTGAGGGCTCACCTAGGAGATCATAGGCAGAGGGCCCCTTTCCCCTATAGGTGGTTCAACGTGGAGGAAGGTTGGGTGTG
GAGATTGCTTGCTGTGGCCCCAAGCTCAGCCAGCAGGACACCCAGTTGTTGCCAATCAGGTGTGAAGGTGAGGCGCCCTGCCTTGATCCC
ATGGGCCCAGCAGAAGGAAACTTACCCCAGGCCAAGGCAAGGGCCCTGCTCACCCCAAGGTAGGCTGGGAAGAGCATCTCTTTCCATATC
ATCACCTCCCCTTCTCCAAGATTGCCGGGGGCCCTGATTTTGTTCTCTCTTTGAAAGAAACCCTCCACCGAAACAATGGTCCCCATCTCC
CCAGAAGCCTTTTTTTTTTTCATTTTTCTCTAATTAGTCTATGCATTTCTCTCTCTCAAACCATCTTCTGCCTCTTCCCTTGAGAAAACG
GGCATCTCACGTACCCCCATCTGAGACCTCTTGGAAAAAAAAAATCCCGTGTATTCTGGAGATGTGAGAATTCACCCAAAATTCTTAAAA
CATTGGAGAATAGCTTGTTATAAAATAAAAGTGGGGGTAAAAAGAAGGTGGTTTTCCCCACATCCCTTTGCATTGAATAAGAGACCTAGT
TCTTTGCGTTTGTGCAATAACTCTTTGCTGCTTGCCTTGAGAGCGGGTAGCACCACGCTCCTGTCCAGACTACTAACAGCACAAGACGCA
CTCACAGGGTGGCGGAATCTTCCGGAAAACTCTCTATAAGCTCAGCTCCCCCCACCCCACCCCCACTCTAGCGTTTTGTCACGTCTTACA
TTTTAGCAGTATTTTATATTTTCTGTAACGCACCAAGTCTTAGATCTTTCTAGAGCTTGTTTGTTCATCCTCACAATCACAGATTTTTTT
CTCCAATCCTCACAGAGACCCAATTGACCAAAAAAGAAAAAAGGAAAAAAAAAAAGTCGTCTTTTTTTTTTTTTTTTGTACAAATCGCTT
TGAGATGCCTCTGGTGTGTTGCTGTGTGACATCTCTCTGGTAACATTTTATTTCTTGCTATTTGTTTTTCTACATTAAGAGTCAAAGTTG
ACCTGGCTGGCGTGGGGGTGGGGGAGGCACCCGTCGGCCCCTTGGTGTTGTCCCTCTGTCTTTGGTTAGCCATACGATGTTTGTTCTCAG
CACTGTACAACGGTCCCTATATAATACGGAGAAGCAATATCACTGTATGAGACTCACACCATGTATTATTATTCACTAGCACCCTAGGTG

>10121_10121_1_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292535_length(amino acids)=1607AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP
GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD
VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ
NILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRS
ILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQG
AADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESP
YSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSV
SDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVK
SLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQ
GSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPR
VVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSC
DGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAP

--------------------------------------------------------------
>10121_10121_2_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292538_length(transcript)=3238nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCAC
TGAGGCTGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGA
TGCCGAGGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGC
CAGCGGTGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCT
TGAGGCCGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGA
GAAGATCAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCT
GGACCCCTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCG
TCTGGTTCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCT
GGCATGGAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAA
CGGGGCTGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGC
ATCTAATCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCG
GGTCCCCTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGAC
CCTCTCAGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGG
GTGACCACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCG
TAAGAGGTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGT
ATATGAGGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCC
TGCCCCCAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCC
CCAGTCTCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCAC

>10121_10121_2_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000292538_length(amino acids)=769AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL
SIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDS
LRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLH

--------------------------------------------------------------
>10121_10121_3_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000360264_length(transcript)=14076nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC
TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC
ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT
TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC
AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA
GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA
TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA
ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG
CAGACAAAGAGAGAATCCAGGCCAGAGCCTGAACAGACTATTTCAGGAAGTACCGAAACGAAGAAATGGGTCTGAAGGTAACATCACCAC
CCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGCCATCAAGTCCATCCTAGAGCAAGCCAAGAGGGAGCTCCAAGTGCAGAAAACTGC
AGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGA
GGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCAC
CTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCT
GCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAG
ACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTC
CGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAG
TCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGAC
CGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCC
CCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAA
GAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATG
GAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCA
GGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAA
GACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTG
TCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCT
CTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGT
GCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCC
CAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCT
GATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGT
CGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGC
GCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGT
CATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGC
CAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGG
CAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTC
GGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGC
GACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGC
GCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGC
CCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGCCGCCAGCCGGGA
GGAACCTATCGAATGGGAGTTCTGAGGGGCCGCGGCCCTGGGGCGGGCAGCCAGGCTGGGCCGCAAGGGCCTGGACGGGGTCGGACGGGG
CAGGCGCTGCGGACACCGTGGCCTGGGCTTGGCCCGCGGCCTGCACCGACCCCGGGCCGGACCTGAGCCCGCAGCCCAGACCCCCTCCAC
GGTCCGCGGCCTGCACCGACCCGAGGCCCAGATCCAAGGCCGCGGCCCAGACCCACTCTGCGGCCCGGGCCGACCCTGCGGCCTCCACCA
ACCCCGCGGCCCAGACCCAGCCCGCGGCCTGGACCCCTGGACCGCTTTGCGCACTTACCGCCCTGCGGGCCACAGGGCAAAATCGCCATA
GGCCAAGGTGCATATAGAAAACAAAGGAGCATTAAGCCCAATCTATGTCGTGTTTTCAAGGAAGAAAACGGAAATGTGTGGTCGAGCTTT
TTTGTACCCTGAAGTGTTTTTTTTATTGCCCTAAGTGATTTCCACAGGTTCTGGAATAACTCTTACAGCTTTGCCTTGTGTCCTCCTGTT
CCGTGTGGGCTTTAAAAGAAAAAAAATCAAACCCACATATTAAAAGGGGGCTTTTTATCTGCCATCTAATGGCTTCAGAGCGATAATACA
CTATTATCTTCTTAAACCAGGAAAAAATAAAAGGGGGGGTGGGATTTTTCAGAAAAATTAAAAAAGAAAGTTTTTGTAGCTGTTCAGTTG
CCACTAAGAGATTGCACAGTCAAAACGACTCTAAACACACTAGTTTGGATTCCTAAATATTTTCAAGAAAAGAATCTTCTCGTTTGAAAC
TTTGAATTAAAATAAAACACATTTACTCCACATATTTTTTAACAAAAAGAAAACGTCACATCAGGAAACTCTGATTTTGTGGTAGCTGAC
ATAGTGTTTTCTTGTACGTGAATAGAATCCTGACATGTAGTGCACATTGATGTATAGCTTTAACTGACCCTGGGTTTTGCAGACCAGGGT
TTGTTTAATACACTCCATTCTAGGCCAAATCAGGACAAAAAAAAGAAAAAAAAAGAAAAAAAAAAAAGAAAAGATCCGAATCTAGGTATT
TTATAATCTGCTTTTTAACCTCTAACCGCAGAGCACGCTGATCAGACCTCATATCTTGGAGGTTTAGGAGACAAGTTAGAACTGTAGCAT
GTACCTGTTAATTTTGTTTAATTTATGGTGTCTCAATCTGTCTGTGCGTCTGCACGTGTGCAAGCATTGAAAGAAAGGAGAGAGTAGTCC
GGGCGAGCACAGCAGGCAGTTCCAGGGCCAGACGGGCCCATCCCCAAGTAGATAGCAGTCTACGGATCTCTCTCTGGCACAGAAGGCACC
TCACCTCACACCACTCTCCTGGATACCTGATGAACTGAGCCCTCCCAGGGGAAGACACTCCCCAGGCCTGGGCAGGGCTTACACGCGCAC
TCTCTCTCTTCTTTCCCTTTTTCTTCCCACCGCAAGCACTGATGACCCTGTTGAACTCGTGGGAAACTTCCTTTCTCTGCAGGAGAGAGA
ACGTGGCATTCTGGGCTCCCCACTCCCATCCCTGTAGAAATGGCCCAAACTCACACCAAAACGTGGATGCTCTTCAACTTCCAAACCTAC
CATTTGCCCTTCTTTCATTTCGCCTCTTAGTTCTTTTTATGCACAGTTTTAGGGCAGTCTAAGTACAAACTGAAAGTCTAACTTGTCTCT
GATTCCTCCCTTGTCTATGTGTATATGCGTGAGAATAGAGGCGGGTGAGAGTGTGCGTGCGTGTGCGTGTGTGCAATTTTATACGTCTGT
GTATTTTCTTAAGTACCTGTGCACACGTAGAGTGCATTACTGCCACCTTTTTCAATAAGCTGTTTTATCAGTTACGGCTTCTACAAGTTT
GCTAATTTAGACTTCTTTATTGCCATATCTTTAAACTAACAATAGATGATTTCGGTATATATATATATTTTTTTTTGCTTATTTATAGGT
GCTGTATTTTATTATCTGATTGTTAGGAAGGGATGAAAGGGGCAAATATTCTTTAGAGGGATAGACTGCCGGCAGTATTGGGTATAATTT
ACAAGATGTAGTTGTCATACTGTATATTACTGATTGAAAACTTTTTGACCGTATTGTGTATCATTGAAACCTTTGTCTTAGGTCAACATC
TTTGGATGACATTTTAATGGTGCATTCATTATTTCTTAAGTTTAATTAATATTACTTTTTTTTTTATTTGGGGGGTGGGAGGGAGTTATA
ATTTTAAAGGTATGCTCTGGCTGTTCCACCTCCGTGTGCTTGTTAATTAACTTGTAGGACTTTGACTGTAAGATGTGAAACCACGTTTCT
TGCATGATGTTTTAGAGATTATTTCATTTACAGTCTTTTAACCTGCAGCTGCAGCACTTAGTTCACGTTTTCACAAATTTCAAGAGTCAC
TACACTAAAGACAATGCCTTTTCATGAATAAGAAGTTTTCAGAAGGCTCTAGGGGGCTGGGAGGCAGGCTGTTCGTTTGTCTTTTGTTGG
GGGTATCATTTCTGAACTTGAAATCCAGTTCAGGGAGAAGAGAATTCAAAATTAGAGGAGCTTAAGGGGACACGGGTCAACATCTAGCTC
GATTCAGGTGCATTGAGAAGAGTGAGTTCACATCGGTGACCCTTAGGACAGTGAGTGGCAGAGCCCTGACGACTGTGGTGTCCTCTCCAC
AAAACCCTCAAGGGACTTTTGTCATCATGTGTGATGAATCTTTAAATATCGTCTAATTTTCATAAGAATGAAAAGAAGTTAACAGGAAAT
AGTAGGCTAGGGTTTAGTTTTAAAGGCATGACTGTTATTTACAAAGGTGTTAAATCTGAGGAAATTGACAAATACAGATTTGTCCATTCT
AGTGGCCAAACAGTAACAGTCTAAAATGCAGTCATTTTGACCCTCCCAAGCAATTTAGTCATATGTGTTGTTTTCTCTTTTCTGTTTTTA
CTTCTTAGATTTTTAACTAGGTTACTGTTGGTTCCCATTCTGTCTTTTTTGCCAGACTTACATCTGGTGCCAGATACAATCAGTTGGTTA
AATTTTGCTTGCAGTTCTGTGTATTTTTTTTCCTCTATTATTTATTTTTTTAAAAAAAATAGAGATCCTAACCTTAGATCTTTGATGTGA
AGCTAGCACTGTCTGTAATACTTCTAAGAGCTGCCACTAAAATAATACAGCAATCCGTGGCCAGGGGAGCACCCCCTCCTGGTTGGGCCC
CTCAGTTGGAGTCTAAGGGTTAATCTCTCATCTTGCTAAGCAGTATTCAAGTGCCTTGAACAGTGTCCCCTCGGCATGGCTCCCCTTCAG
CAGGCTGGCATTCCAAGCAGTGGCCCCCGCAGGCAGCCGACCCCCTTCCTCTTCACGCTCTATGAGTTTAAAAAGCTGATTTGTACCTCT
CCCCTGGGGGAAACGGTTCCATATAAAACACTAACACTTAATTACAAGCTCCATTATGCCATTTTAAATGGCTTCTTTTTGTTAATTGGA
GGCATTGTTCATAACTTAAGGCTTTTGCCATTAACTTAGCTGGCTAAGCAGAGGCTCGGGGTAAAATCAGTGTTTGCATTTAGCCTCTTG
ACCCGGAGTTCCGGCCCAAGCTCCCTTGTGATAGCCGAGATGGCAGGTGTGTGAGTTCTGTCCTAGACCTGTGCCCAACTCACTTCCACC
CCAGAGGAGTCTTCTGTCCTCCTCCCCAACCCCCGAGCTCCCTGGTAACCTCCTCTTGAACTTCTGTATCAGTGAAGACATCTGTGGTTT
CTGCTCACCAGACCTCTCTTTAGAAAGGGTTATCAGAGCCATGGAGCTTAGCTCAATTGGATTCTTCTAGACGATCTTAGGAGGCATCTT
GGCATGAGGCAGCTTCTAAGCGTCTCCTGGGACAGGATTGGGGTGACAGCCCAGGGATGCATGCATGGGAGAACTCTCTGAGAAATGCCA
GGATCGTGGCTCACAGGGACCCACCATCAAAACCTGCTACTTTGTGCAAGTAATTGAGGCAAAAGATACCAGTCGACAGCCTCCCTGGGG
TAGATCCCTTGTACCTCCAAAGTACAAATACCTCCCTGCTCAGTTTCCTTCCTGTCGCCATCTTTGTTTTCTTCCCATTGAAAAACCATC
CTGTCTGATGTGGACGTTCAGGTCTGCTGGTTGGCGGTCCGGGCCCAGAGTGCAGCAGAGCTCTGGGTTAAATATTCCTTTCTGGCCACC
GCCCAAGCCCAGGTGGCCAGCTCTCATACCCCATCTCCCTCCTTGGCCAGGGCCAGCATCAGGCGTGCAGCTCATGACCAGTTTACACAG
GCTGCAAAGAGATCGCTGTGGGCCTCGGCTGACTACTTTAAGATTATGCCACAGCCAGGCCCTAAAAAGAGAGGGGAACAGGAGTCCCCA
GGTGAGCTCTCTGACGGGCAGGTGCCTTCCCGACTAAGGTTGGACTGGATGACTTTGTTCCTCCTGCATGCATGTCCTTTGATGCAAGGG
TGATCAATGAACTCTGTTGACATTCTATGCAATGTTTTTCATTCCTCTGATTTTAGCAAAGCAAATCTTACTGAAAAATAGCAGAGCCAG
GGGAACAGACGCATGTCCTTCTGGGAGTCACACAAAAGCAGAGAGATTTTGAACTGAGGGGCGACAGCCTTTGCCTTAAATGCAGTATGA
CAGGCGCTTCTTGGCAGACCAGTAAAAACAAAAGCCCATAGACCTTACTCATCCCAAGGCCGACAAGCCAGCTGTACAGGGCGAGATGTA
GCAACACGGGGCATGAGCGGTGGGCGTGCTGGGCTATTTGCTGTGGTACTTTAGGCTGGAGGTTTGGCTCCTGTGCTGCCGGTGGGGGGC
CCTGTCCCTCCCCAGATGTCCTCCCTCTTCTTCACACTCCTCATTGTCCCTTCTACCTCACTAACCTGTCTTCTCCATCTGATGTCACCC
AGAACCACACCCCACAGAACTGTGAGGCACGTGGGCTGGAGAGAGCAGAAAAGCTGCCAGCGCAGCAGACACGAACATCCCTCTGCCTGG
TGGGCCGGCTTTGTGTGTCTCTCCTTTTGTGAGCGCAACACGGACAAACAGCTGTGCTCTGCAAGGCACACGGATGTTTCCCTTCCACCT
GTTCCCAAAGCTCCAGCAGCTGTTTCTTTTGCAGGCAGGGCGTGGTCTCGGGGCTCCGAGGGTCTTGTCTTTGGTCCGCCTTCCTTTCTG
TCCAGTCCTGCTCAGCTGTTAAGATCCATCATGGCCATTATCCTTGTCCCGGACTGCCCCAAAGTTCCCAGCTGGCTTTGGGGAACACTG
TAGCTCTTGGGTGTCTCTTGTCTCTGGCATGGTTTTAGCGTCACTGCGAACACTCCTTTGCAAACATCAAACATCTCAAAGACGGAAAAG
GATAGATGGCTTCCTCCAGCCTACACGCCCCGTCCACAGTGGCATCACCCTCTTATCCCAAAAGAATATGCCAGTTCCCATCCAGCACCG
AAGAAAATCAGCTCCTGGGGCTGGTGGTTGGAGGTGGGTCTGTCCACTGTGGGGGCCAAAGTGTTCCCCTGCTGGAGACAGTTTGCAAGT
AAGAACCTAAGGATGGGGACAGCATCCTGTGCTTGGGCATTGACCAGCCAAAGCTCACATTTAGAAAGCCCTCAGTGCTTCTGTGGTTTC
ACCTGGGCATCGACGACATTAGGGAAGCCTTTGTGACCACAAGGGCAGGGCTTGTGCCCTGAGTGGCGAGGTGGTGACCTGAGGCCAGTG
TGATGTGGTTGGATCTCAGCGTGTACTGAATGCCAGTCTGGCCGGCACACTCGAACGCTAAGAGAATGGTCCAATTTGATGATCTTATTT
CTATTTCGATCAGGTTTTGACTTTTTGTAGATGAAAACTACCAGGGAAAAGGGGAAGCAGGTACCCAATAAAGTTTAGAAAGATCCAGTC
TGTGAAACCCTTAGAGATGGGCTGAAAGTTAAGTCCACCAACCCTTGGGCTTAATCAGGACGGAAGAGGAGGGGGTGTGGGGGGCAGAGC
GTAAAACAAGCCCCAGCCCTACTCCCGGCCCCCCAGCCCAGTCTTCCCAATCCCAGAGGCCCCGGCGGCCTGTGCTCCTCACCACCCTGG
TCAGGGGAATAGAAGGAAATGCAATTTCCGCCTGTCTGCCCGACTTCCAAAAACTGCCTCCTCCTGCCCAGGCCTCTCCCACCACCACCT
TCCCTCCAAAGATAACCGTGTCCATGCCATCCGTGGCATCATCTCGAGTTTTCATTTTTGGATGAAGTGACATTTAGCTTTAACAAGACA
TTTCCAAAGCGCCTAGTCTCCTCCAAAATGCTAACTTTAAAAGTTGGGCATTGTAGGCGAAAAATCCCAAAAAAAAAAAAAGACAAAAAA
AAAAGGCTGGCGAGAGAAAGACATTTGGCTATGCATAAATGTGCACTTCCCCCATGCCCCCGTTCTTAAACTCTTAAGATGCCTTTGAGT
TGCTTTTCATGAATCCTTTTAGTTTACCCGATAATGTTAAGAAAGCATTAGTCTACGTTACTGTAATTTCTGTAGTGTTTACGCTTTAAT
TTCTACCACAAAATATGCTATATGCTATGTATCAAGCTTTCTGTAATCAGAAAGAAAAGGTGCCTTATATCCCAATGTCACGGCTACATC
CCTATGGAAATTAATCAGAAGCACAGTGTGTACGGAAGCATTGGGACTTCTGCTGGTGAAACAAGAGACCATTCAGCAAGACACATTGAA
GTGGCACGGAGCTGCTTTTGTTTTATAATTCTTTTTTCCCCCCTTTTCCTTCTTCTTTTTTATTATTTTATTATTTTTTTTGTACTTTGC
TTTAAACGGAAAGCACTTAAATAGATGACTATGTGTAAAAGCTCTGTGCAATTGAAATCATTTTTCTTCATTTTAAAAAAATAACGTATT
GCACACCAAATGAACTCAAAGTAAGCTTTAGACCAGGACGATTCAGGTTATGAATGAGTTTGTTCACTGTAGTTCCGTTTGTTCATGAAC
CGAAGGGAAAACAGGCCTCCCCGACTCCCTCCAGTCTCCCAGCCTGCCTCTTGGTGACCACTGTGCTGGGCGTGCAGGGCCCGCGGGCTC
TGGCCGGAGCCGCTGGCCTGACGAGGCAGGATAGGGAGTATCCGTGATTCAGAAGCTGAGACCCTTCCCCAGTGTCTGAGGCCACAGCCA
TCCCTTCCAGCACTTAATCTTGTCTTGTTGAAATGGACTGACTGCTACTGACCTGCCGGCGTGCGTGAGGGTGATTATAAAAGGATGTTT
CCTTGAGAAAAAAAAAATTATTTCTATCCTCTTCTATTTATTATTAGGTTAATCATTTAAGTACTTATCAGGAGTGTATTGTTATTTTGT
GTTTTGTTGTCATAAATGCTTTTTGCTGTCACTCTAGTGGTTACTATCCTCTGCCTTCCTCTCCTCCCCTACTCCCCCAGAGAACCAAGG
CGTCTGGGGGATTGACTGGGGGGCAGAGGGGGTTTCCCCAGCAAAATCAAACACCTGTCTCCAGAGTAGCCACTCAAAAACTGGTGGTCT
CTATGTGTCTAACTTTTTAAATGAGAGTGTTTATGAACAAAAAAATTTACCAACGTGTGAGGGAGTTGCTGAGTTGAAGAATGCTCGCTT
GAGGAGCTTCAGAGGAATCTTAGCAAAGCCAAGTTCAGTTCCCCAAAGCCTCCTAGAGCCTCTGGTAAGACTTCTGGGTTCATGAAGTTT
CGGCGAGCCGTGGTCAGAGAGGGCGCGGTGGCCTGGCCAAGACTTTACCTCCAAGCGAGAGAGTGATTTCTTGCAAGGCCCGCATGGGTT
GATACGTTTTGGTTGGTTTTTTGTTGTTGTTTTTCTTGCGTACAAAGTTGGTCAAAACCATCTTTCAAAGCAACAGTGTTTTGTAGTACC
AGGCTGTGGCTTGAGGGCTCACCTAGGAGATCATAGGCAGAGGGCCCCTTTCCCCTATAGGTGGTTCAACGTGGAGGAAGGTTGGGTGTG
GAGATTGCTTGCTGTGGCCCCAAGCTCAGCCAGCAGGACACCCAGTTGTTGCCAATCAGGTGTGAAGGTGAGGCGCCCTGCCTTGATCCC
ATGGGCCCAGCAGAAGGAAACTTACCCCAGGCCAAGGCAAGGGCCCTGCTCACCCCAAGGTAGGCTGGGAAGAGCATCTCTTTCCATATC
ATCACCTCCCCTTCTCCAAGATTGCCGGGGGCCCTGATTTTGTTCTCTCTTTGAAAGAAACCCTCCACCGAAACAATGGTCCCCATCTCC
CCAGAAGCCTTTTTTTTTTTCATTTTTCTCTAATTAGTCTATGCATTTCTCTCTCTCAAACCATCTTCTGCCTCTTCCCTTGAGAAAACG
GGCATCTCACGTACCCCCATCTGAGACCTCTTGGAAAAAAAAAATCCCGTGTATTCTGGAGATGTGAGAATTCACCCAAAATTCTTAAAA
CATTGGAGAATAGCTTGTTATAAAATAAAAGTGGGGGTAAAAAGAAGGTGGTTTTCCCCACATCCCTTTGCATTGAATAAGAGACCTAGT
TCTTTGCGTTTGTGCAATAACTCTTTGCTGCTTGCCTTGAGAGCGGGTAGCACCACGCTCCTGTCCAGACTACTAACAGCACAAGACGCA
CTCACAGGGTGGCGGAATCTTCCGGAAAACTCTCTATAAGCTCAGCTCCCCCCACCCCACCCCCACTCTAGCGTTTTGTCACGTCTTACA
TTTTAGCAGTATTTTATATTTTCTGTAACGCACCAAGTCTTAGATCTTTCTAGAGCTTGTTTGTTCATCCTCACAATCACAGATTTTTTT
CTCCAATCCTCACAGAGACCCAATTGACCAAAAAAGAAAAAAGGAAAAAAAAAAAGTCGTCTTTTTTTTTTTTTTTTGTACAAATCGCTT
TGAGATGCCTCTGGTGTGTTGCTGTGTGACATCTCTCTGGTAACATTTTATTTCTTGCTATTTGTTTTTCTACATTAAGAGTCAAAGTTG
ACCTGGCTGGCGTGGGGGTGGGGGAGGCACCCGTCGGCCCCTTGGTGTTGTCCCTCTGTCTTTGGTTAGCCATACGATGTTTGTTCTCAG
CACTGTACAACGGTCCCTATATAATACGGAGAAGCAATATCACTGTATGAGACTCACACCATGTATTATTATTCACTAGCACCCTAGGTG

>10121_10121_3_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000360264_length(amino acids)=1607AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP
GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD
VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ
NILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRS
ILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQG
AADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESP
YSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSV
SDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVK
SLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQ
GSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPR
VVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSC
DGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAP

--------------------------------------------------------------
>10121_10121_4_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000393824_length(transcript)=2753nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGAGATCGC
ACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGAGCAGCA
GCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCTGAACAT
TCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAAGAACCG
CTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCACTGAGGC
TGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGATGCCGA
GGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGCCAGCGG
TGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCTTGAGGC
CGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGAGAAGAT
CAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCTGGACCC
CTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCGTCTGGT
TCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCTGGCATG
GAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAACGGGGC
TGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGCATCTAA
TCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCGGGTCCC
CTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGACCCTCTC
AGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGGGTGACC

>10121_10121_4_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000393824_length(amino acids)=767AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD
YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSI
IQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR
ADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCL

--------------------------------------------------------------
>10121_10121_5_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000425244_length(transcript)=3238nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCAC
TGAGGCTGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGA
TGCCGAGGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGC
CAGCGGTGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCT
TGAGGCCGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGA
GAAGATCAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCT
GGACCCCTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCG
TCTGGTTCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCT
GGCATGGAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAA
CGGGGCTGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGC
ATCTAATCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCG
GGTCCCCTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGAC
CCTCTCAGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGG
GTGACCACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCG
TAAGAGGTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGT
ATATGAGGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCC
TGCCCCCAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCC
CCAGTCTCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCAC

>10121_10121_5_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000425244_length(amino acids)=769AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL
SIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDS
LRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLH

--------------------------------------------------------------
>10121_10121_6_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000437600_length(transcript)=3232nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGAGATCGC
ACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGAGCAGCA
GCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCTGAACAT
TCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAAGAACCG
CTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCACTGAGGC
TGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGATGCCGA
GGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGCCAGCGG
TGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCTTGAGGC
CGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGAGAAGAT
CAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCTGGACCC
CTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCGTCTGGT
TCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCTGGCATG
GAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAACGGGGC
TGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGCATCTAA
TCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCGGGTCCC
CTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGACCCTCTC
AGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGGGTGACC
ACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCGTAAGAG
GTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGTATATGA
GGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCCTGCCCC
CAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCCCCAGTC
TCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCACCTCTCA

>10121_10121_6_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000437600_length(amino acids)=767AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD
YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSI
IQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR
ADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCL

--------------------------------------------------------------
>10121_10121_7_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000546411_length(transcript)=4579nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGTCCATACAGCACAAACTCCATATCTTCCCA
AAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCAGTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGA
GATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAATATCGGACAACGTATTTTCGGACATTATGTGTTGGG
ACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAAACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGAT
GAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGGCAGACAAAGAGAGAATCCAGGCCAGAGCCTGAACAG
ACTATTTCAGGAAGTACCGAAACGAAGAAATGGGTCTGAAGGTAACATCACCACCCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGC
CATCAAGTCCATCCTAGAGCAAGCCAAGAGGGAGCTCCAAGTGCAGAAAACTGCAGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGG
GAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCA
GGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCT
CGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGA
CGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTG
GAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAA
AGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAA
GGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCC
CCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTA
CCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGT
GCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCAT
CCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGAC
ATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCC
GATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACC
AGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGT
AGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCAGCGCTTATTTGG
GGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGA
GCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCTGATGGACATGAAACGGATGGAGAAGAAAGCCTACAT
GAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCC
CCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTC
ACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGTCATCAACTGGTTCCACAACTACAGGTCTCGGATCCG
CAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGC
GCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGA
GGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGCCCGCGACGACGA
CCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGC
CGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCC
CCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAA

>10121_10121_7_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000546411_length(amino acids)=1506AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE
SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQ
RENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ
QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQV
KNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA
SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSK
LTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP
IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKP
WHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK
RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSA
DTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP

--------------------------------------------------------------
>10121_10121_8_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000547394_length(transcript)=3238nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGACGCTGTGCAGAGCTGCAAGTCCGTATCAC
TGAGGCTGTGGCCACAGCCACTGAGCAGAGAGAGCTGATCGCCCGCCTGGAGCAGGACCTGAGCATCATTCAGTCCATCCAGCGGCCCGA
TGCCGAGGGTGCCGCTGAGCACCGCCTGGAGAAGATCCCAGAGCCCATCAAAGAGGCCACTGCCCTATTCTACGGACCTGCAGCACCAGC
CAGCGGTGCCCTCCCAGAGGGCCAGGTGGATTCACTGCTTTCCATCATCTCCAGCCAGAGGGAGCGCTTCCGTGCCCGGAACCAGGAGCT
TGAGGCCGAGAACCGCCTGGCCCAGCACACCCTCCAGGCCCTGCAGAGTGAGCTGGACAGCCTGCGCGCCGACAACATCAAGCTCTTTGA
GAAGATCAAGTTCCTGCAGAGCTACCCTGGCCGGGGCAGCGGCAGTGATGACACGGAGCTGCGGTACTCGTCCCAGTACGAGGAGCGCCT
GGACCCCTTCTCCTCCTTCAGCAAGCGGGAGCGGCAGAGGAAGTACCTGAGCTTGAGTCCCTGGGACAAGGCCACCCTCAGCATGGGGCG
TCTGGTTCTCTCCAACAAGATGGCGCGCACCATCGGCTTCTTCTACACACTGTTCCTGCACTGCCTGGTCTTCCTGGTGCTCTACAAGCT
GGCATGGAGCGAGAGCATGGAGAGGGACTGTGCCACCTTCTGCGCCAAGAAGTTCGCTGACCACCTGCACAAGTTCCACGAGAATGACAA
CGGGGCTGCGGCTGGTGACTTGTGGCAGTGATACCCCGGGGCCTCCCCCGTGACAGTGACGGCTGCGCCTCCACCCCGACTGCTCAGTGC
ATCTAATCACTTAGACTCCCCTGAAGAATCCCCCATGGAAACTGCCCTTATCCGCTGTCCAGCAGCTGCCAGAGGCCCCAGGTCACCTCG
GGTCCCCTTGAAAGAATGTCTCGGTCACATCAGGCCCGCTAGGTCCAGAGAGCGAGCCCCCAATGCCCGGCCAGGCTAAGCCGCAGAGAC
CCTCTCAGCCCCCACCTCAGGTTAGGGCTCTGCCCGCAGCCTGACCTCTAGCCCTGGTGGCAGAGGTCCCTCAGCTGCGAGGCTAATTGG
GTGACCACCGATTCCAGCTGCGGTTAATCCAGCTTGGGCCTGTCTGCACTGCGATCCTCTTGGGCTCTCCTAGGATCCCCCCATGCCCCG
TAAGAGGTGGAAGACGCTTCCTTCCAGGACAGCAGGCTTTGAGTCCAGCACCCCCAGCCTGCCTTTGCCACCAGCCCCACCCTGCAGAGT
ATATGAGGCTTGACAGAGTCTGCCCCCTCCCCCACTGCACCCCAAGAGAGAGAGCCCCAGCCAGCGGAACAGTTTCTATTACCCCCTCCC
TGCCCCCAGACCCATGTGATTTCTGCTTTCTTCTTTAGCAAGATATTCTGGTTTCTAGATAAGGAAGAGTCTCTAATGAGCCCCCGAGCC
CCAGTCTCTTCAGACTCATGGATTGGTCTGAGGGGTCTGAACGTCTCCTAGCCAATCAGAACTGGCTGTGGACCACCCTAGCACGGCCAC

>10121_10121_8_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000547394_length(amino acids)=769AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL
SIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDS
LRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLH

--------------------------------------------------------------
>10121_10121_9_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000549414_length(transcript)=4819nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC
TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC
ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT
TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC
AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA
GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA
TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA
ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG
CAGACAAAGAGGTAACATCACCACCCGGATCCGAGCCTCGGAGACTGGCTCTGATGAAGCCATCAAGTCCATCCTAGAGCAAGCCAAGAG
GGAGCTCCAAGTGCAGAAAACTGCAGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCT
GCAGCAAGCCCGCCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCAT
CCTCACCCCCAAGCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGC
TCCTGAGGCCGGTGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGC
CGATTGTGCACAAGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCC
GGAGAGAAGAAATGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGG
CAGCCAGCCTCGGGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTC
CCAGAGCTCAGAGCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTC
CAAGCCCACCAAGCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCG
GCAGGTTAAGGAAAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGA
CATGCTGTCCCGACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCT
AGGCCAGGGTGTTCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTG
TGTGAGCTCAGAAAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCT
GACCGAGCTGGTCCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTC
CCAGCCCACAACCCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGG
CATAACCAAGCGGGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTC
TGTCTCTGACCTCCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAA
CGACCCCAACAATGTGGAGAAGCTGATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAG
CCAGCCCTGCGAACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGT
GCTGGCTCCGGAGGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCA
GCTCAACCTGAAAACCAGCACCGTCATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGC
CGGGAGTCAGGGCCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGG
CGTGGAGGCCACTGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGC
GGAGCAGACGGAGCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGG
GCCCCTGCCCAGCCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGA
GGGCCCCGCGGCCCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTT
CGGCCTCCCCGAGGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCG

>10121_10121_9_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000549414_length(amino acids)=1586AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP
GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD
VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ
NILALRSIQGRQRGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQ
APLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAW
KDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSP
LPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFI
RMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPP
EPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGRE
PFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPS
PKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGE
AEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAP

--------------------------------------------------------------
>10121_10121_10_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000550008_length(transcript)=4717nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGGTCAGCCAGGAGGAAAGGGAAAGACCAGCC
TGAAAGTCGGCGCCCGGGATCTTTGCCGGCCCCCCCTCCTTCTCAGTTGCCCCGCAACCCGGGGGAGCAGGCTTCCAATACTAATGGTAC
ACACCAGTTCTCACCAGCGGGGTTAAGTCAAGACTTTTTCAGCTCATCCCTGGCAAGCCCCAGCCTACCCCTGGCTTCTACAGGAAAATT
TGCACTAAACTCTCTTCTCCAGCGGCAGCTAATGCAGTCCTTCTACTCCAAGGCTATGCAGGAAGCCGGAAGCACAAGCATGATTTTTTC
AACAGGTCCATACAGCACAAACTCCATATCTTCCCAAAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCA
GTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGAGATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAA
TATCGGACAACGTATTTTCGGACATTATGTGTTGGGACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAA
ACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGATGAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGG
CAGACAAAGAGCAGAGCCGGCCCAGCCTTCCTCCGCATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCG
CCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCCTGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAA
GCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAGCTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGG
TGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAAGGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACA
AGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCGCAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAA
TGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAACGGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCG
GGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTCAGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGA
GCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACCACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAA
GCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGAGGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGA
AAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTTCGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCG
ACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCGAGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGT
TCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCTCCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGA
AAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGCCCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGT
CCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGACAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAAC
CCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCATCCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCG
GGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCAGCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCT
CCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCTGAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAA
TGTGGAGAAGCTGATGGACATGAAACGGATGGAGAAGAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGA
ACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGCCAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGA
GGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAAGCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAA
AACCAGCACCGTCATCAACTGGTTCCACAACTACAGGTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGG
CCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAGCGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCAC
TGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAAGTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGA
GCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGCCCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAG
CCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGCCCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGC
CCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAGCAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGA
GGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCTGCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGC

>10121_10121_10_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000550008_length(amino acids)=1552AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNP
GEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD
VNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQ
NILALRSIQGRQRAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISL
KKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGS
GGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVD
TIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQD
PLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSP
ELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRH
SSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELF
IEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGG
PVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANL

--------------------------------------------------------------
>10121_10121_11_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000556210_length(transcript)=4411nt_BP=1041nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGGCCGACGAGATTGAAATGATCATGACGGACCTTGAAAG
GGCAAACCAGAGGGCAGAGGTGGCTCAGAGAGAGGCGGAGACCTTAAGGGAACAGCTCTCATCGGCCAATCACTCCCTCCAGCTGGCCTC
ACAGATCCAGAAGGCACCAGACGTGGAGCAGGCCATAGAGGTGCTGACCCGCTCCAGCCTAGAAGTTGAGTTGGCCGCCAAGGAGCGGGA
GATCGCACAGCTGGTGGAGGACGTGCAGAGACTCCAGGCCAGCCTCACCAAGCTGCGGGAGAATTCGGCCAGCCAGATCTCACAGCTTGA
GCAGCAGCTGAGCGCCAAAAACAGCACACTCAAACAACTGGAAGAAAAACTCAAAGGCCAGGCTGACTATGAAGAGGTGAAGAAAGAGCT
GAACATTCTGAAGTCCATGGAGTTTGCACCGTCCGAGGGCGCTGGGACACAGGATGCGGCCAAGCCCCTGGAGGTGCTGTTGCTGGAGAA
GAACCGCTCGCTGCAGTCCGAGAACGCCGCGCTGCGCATCTCCAACAGCGACCTGAGCGGTCCATACAGCACAAACTCCATATCTTCCCA
AAGTCCATTACAACAAAGCCCAGATGTCAATGGCATGGCCCCATCCCCCAGCCAGTCAGAAAGTGCTGGGAGCGTCTCCGAGGGCGAGGA
GATGGACACTGCAGAAATCGCCCGGCAGGTCAAAGAGCAGCTGATTAAGCACAATATCGGACAACGTATTTTCGGACATTATGTGTTGGG
ACTGTCTCAAGGGTCCGTGAGCGAGATTCTGGCCCGGCCCAAGCCATGGAATAAACTGACTGTTCGTGGCAAGGAGCCATTTCACAAGAT
GAAACAGTTCCTCTCCGATGAGCAGAACATCCTGGCCCTCCGTAGCATCCAAGGCAGACAAAGAGCAGAGCCGGCCCAGCCTTCCTCCGC
ATCCGGCAGCGGGAACTCTGATGACGCCATCCGCTCCATCCTGCAGCAAGCCCGCCGGGAGATGGAGGCCCAGCAGGCTGCCCTCGACCC
TGCCTTAAAGCAGGCACCACTGTCCCAGAGTGACATCACCATCCTCACCCCCAAGCTTCTGTCCACCTCGCCCATGCCCACCGTGTCCAG
CTACCCACCTCTCGCCATCTCCCTGAAGAAGCCCTCCGCAGCTCCTGAGGCCGGTGCCTCTGCTCTGCCGAACCCCCCGGCCCTCAAAAA
GGAGGCCCAGGACGCCCCCGGGCTGGACCCCCAGGGAGCAGCCGATTGTGCACAAGGGGTCCTGAGACAGGTGAAAAATGAGGTGGGCCG
CAGCGGTGCCTGGAAGGACCACTGGTGGAGCGCGGTGCAGCCGGAGAGAAGAAATGCCGCCTCCTCCGAGGAGGCCAAGGCCGAAGAAAC
GGGCGGCGGGAAAGAGAAGGGCAGCGGTGGCAGCGGAGGTGGCAGCCAGCCTCGGGCCGAGCGCAGTCAGCTCCAGGGACCCTCGTCGTC
AGAGTACTGGAAGGAGTGGCCCAGCGCTGAGTCCCCATACTCCCAGAGCTCAGAGCTGAGTCTGACCGGGGCCAGCCGCAGCGAGACACC
ACAGAACAGCCCCCTGCCATCCTCCCCGATCGTGCCCATGTCCAAGCCCACCAAGCCCTCGGTCCCCCCGCTGACCCCCGAGCAGTACGA
GGTCTACATGTACCAGGAGGTGGACACCATCGAGCTCACCCGGCAGGTTAAGGAAAAGCTGGCCAAGAACGGCATCTGCCAGAGAATCTT
CGGGGAGAAGGTGCTGGGCCTGTCCCAGGGCAGCGTCAGCGACATGCTGTCCCGACCGAAGCCATGGAGCAAGCTGACGCAGAAAGGCCG
AGAACCCTTCATCCGGATGCAGCTCTGGCTGAACGGCGAGCTAGGCCAGGGTGTTCTACCCGTCCAGGGCCAGCAGCAAGGGCCAGTCCT
CCACTCCGTGACATCGCTCCAGGACCCGCTGCAGCAGGGCTGTGTGAGCTCAGAAAGCACTCCAAAGACCTCCGCCAGCTGCAGCCCTGC
CCCTGAGTCCCCGATGAGTTCCAGTGAGTCGGTGAAGAGCCTGACCGAGCTGGTCCAGCAGCCCTGTCCCCCCATCGAGGCGAGCAAGGA
CAGCAAGCCACCAGAGCCCAGTGACCCGCCAGCATCCGACTCCCAGCCCACAACCCCGCTGCCTCTCTCCGGACACTCGGCCCTCAGCAT
CCAAGAATTAGTAGCCATGTCCCCGGAGCTGGACACCTACGGCATAACCAAGCGGGTGAAGGAGGTGCTGACGGACAACAACCTCGGCCA
GCGCTTATTTGGGGAGACCATCTTAGGGCTCACCCAAGGCTCTGTCTCTGACCTCCTTGCCCGCCCCAAACCCTGGCATAAGCTCAGTCT
GAAAGGACGAGAGCCCTTCGTCCGGATGCAGCTGTGGCTGAACGACCCCAACAATGTGGAGAAGCTGATGGACATGAAACGGATGGAGAA
GAAAGCCTACATGAAGCGGCGGCACAGCTCAGTCAGTGACAGCCAGCCCTGCGAACCGCCCTCTGTCGGCACCGAGTACAGCCAGGGCGC
CAGCCCCCAGCCCCAGCACCAGCTGAAGAAACCCCGGGTGGTGCTGGCTCCGGAGGAGAAGGAGGCGCTGAAACGAGCGTATCAGCAAAA
GCCATACCCGTCACCAAAAACCATCGAAGACCTCGCCACCCAGCTCAACCTGAAAACCAGCACCGTCATCAACTGGTTCCACAACTACAG
GTCTCGGATCCGCAGAGAACTGTTCATTGAGGAAATTCAGGCCGGGAGTCAGGGCCAGGCGGGCGCCAGCGACTCACCCTCGGCCCGCAG
CGGCCGGGCGGCGCCCAGCTCGGAGGGCGACAGCTGCGACGGCGTGGAGGCCACTGAGGGCCCAGGCAGCGCCGACACCGAGGAGCCCAA
GTCTCAGGGAGAGGCCGAGCGGGAGGAGGTGCCGCGGCCGGCGGAGCAGACGGAGCCGCCGCCCTCGGGGACCCCGGGCCCGGACGACGC
CCGCGACGACGACCACGAGGGAGGCCCCGTGGAAGGCCCGGGGCCCCTGCCCAGCCCCGCCTCCGCGACCGCCACCGCCGCGCCCGCGGC
CCCCGAGGACGCCGCTACCTCAGCCGCCGCCGCGCCGGGGGAGGGCCCCGCGGCCCCGAGCTCCGCGCCGCCGCCCAGCAACAGCAGCAG
CAGCAGCGCCCCCCGCAGGCCCAGCTCGCTGCAGAGCCTTTTCGGCCTCCCCGAGGCCGCGGGCGCCCGGGACTCGCGCGACAACCCCCT
GCGCAAGAAGAAGGCCGCGAACTTGAACAGCATCATCCACCGCCTGGAGAAGGCCGCCAGCCGGGAGGAACCTATCGAATGGGAGTTCTG

>10121_10121_11_BRAF-CUX1_BRAF_chr7_140500162_ENST00000288602_CUX1_chr7_101801840_ENST00000556210_length(amino acids)=1450AA_BP=327
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGADEIEMIMTDLERANQRAEVAQREAETLREQLS
SANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ
ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE
SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQ
RAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGAS
ALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAE
RSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKL
AKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSEST
PKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVK
EVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPP
SVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQA
GASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPA
SATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAAS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRAF-CUX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRAF-CUX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRAF-CUX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource