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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRAF-FAM114A2 (FusionGDB2 ID:10124)

Fusion Gene Summary for BRAF-FAM114A2

check button Fusion gene summary
Fusion gene informationFusion gene name: BRAF-FAM114A2
Fusion gene ID: 10124
HgeneTgene
Gene symbol

BRAF

FAM114A2

Gene ID

673

10827

Gene nameB-Raf proto-oncogene, serine/threonine kinasefamily with sequence similarity 114 member A2
SynonymsB-RAF1|B-raf|BRAF1|NS7|RAFB1133K02|C5orf3
Cytomap

7q34

5q33.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene protein FAM114A2testis tissue sperm-binding protein Li 81P
Modification date2020032920200313
UniProtAcc

P15056

Q9NRY5

Ensembl transtripts involved in fusion geneENST00000288602, ENST00000518946, 
ENST00000520313, ENST00000351797, 
ENST00000520667, ENST00000522858, 
Fusion gene scores* DoF score28 X 21 X 11=64684 X 3 X 4=48
# samples 324
** MAII scorelog2(32/6468*10)=-4.3371758685863
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRAF [Title/Abstract] AND FAM114A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRAF(140482821)-FAM114A2(153382529), # samples:3
FAM114A2(153390801)-BRAF(140481493), # samples:3
Anticipated loss of major functional domain due to fusion event.FAM114A2-BRAF seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FAM114A2-BRAF seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FAM114A2-BRAF seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

HgeneBRAF

GO:0006468

protein phosphorylation

17563371

HgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

HgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

HgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

HgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

HgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check buttonFusion gene breakpoints across BRAF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM114A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-ET-A3BN-01ABRAFchr7

140482821

-FAM114A2chr5

153382529

-


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Fusion Gene ORF analysis for BRAF-FAM114A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000288602ENST00000518946BRAFchr7

140482821

-FAM114A2chr5

153382529

-
5CDS-intronENST00000288602ENST00000520313BRAFchr7

140482821

-FAM114A2chr5

153382529

-
In-frameENST00000288602ENST00000351797BRAFchr7

140482821

-FAM114A2chr5

153382529

-
In-frameENST00000288602ENST00000520667BRAFchr7

140482821

-FAM114A2chr5

153382529

-
In-frameENST00000288602ENST00000522858BRAFchr7

140482821

-FAM114A2chr5

153382529

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000288602BRAFchr7140482821-ENST00000351797FAM114A2chr5153382529-47481375611899612
ENST00000288602BRAFchr7140482821-ENST00000522858FAM114A2chr5153382529-31731375611899612
ENST00000288602BRAFchr7140482821-ENST00000520667FAM114A2chr5153382529-23771375611899612

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288602ENST00000351797BRAFchr7140482821-FAM114A2chr5153382529-0.0004127670.99958724
ENST00000288602ENST00000522858BRAFchr7140482821-FAM114A2chr5153382529-0.0007248410.99927515
ENST00000288602ENST00000520667BRAFchr7140482821-FAM114A2chr5153382529-0.0013116680.9986883

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Fusion Genomic Features for BRAF-FAM114A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BRAF-FAM114A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140482821/chr5:153382529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRAF

P15056

FAM114A2

Q9NRY5

FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140482821chr5:153382529ENST00000288602-1018122_129438767.0Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140482821chr5:153382529ENST00000288602-1018428_432438767.0Compositional biasNote=Poly-Ser
HgeneBRAFchr7:140482821chr5:153382529ENST00000288602-10186_11438767.0Compositional biasNote=Poly-Gly
HgeneBRAFchr7:140482821chr5:153382529ENST00000288602-1018155_227438767.0DomainRBD
HgeneBRAFchr7:140482821chr5:153382529ENST00000288602-1018234_280438767.0Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRAFchr7:140482821chr5:153382529ENST00000288602-1018457_717438767.0DomainProtein kinase
HgeneBRAFchr7:140482821chr5:153382529ENST00000288602-1018463_471438767.0Nucleotide bindingATP
TgeneFAM114A2chr7:140482821chr5:153382529ENST00000351797814268_295331506.0Coiled coilOntology_term=ECO:0000255
TgeneFAM114A2chr7:140482821chr5:153382529ENST00000520667915268_295331506.0Coiled coilOntology_term=ECO:0000255
TgeneFAM114A2chr7:140482821chr5:153382529ENST00000522858814268_295331506.0Coiled coilOntology_term=ECO:0000255
TgeneFAM114A2chr7:140482821chr5:153382529ENST00000351797814297_302331506.0Compositional biasNote=Poly-Glu
TgeneFAM114A2chr7:140482821chr5:153382529ENST00000520667915297_302331506.0Compositional biasNote=Poly-Glu
TgeneFAM114A2chr7:140482821chr5:153382529ENST00000522858814297_302331506.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for BRAF-FAM114A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10124_10124_1_BRAF-FAM114A2_BRAF_chr7_140482821_ENST00000288602_FAM114A2_chr5_153382529_ENST00000351797_length(transcript)=4748nt_BP=1375nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCAT
TCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCA
TATAAACACAATAGAACCTGTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGC
TACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTC
ATCCTCAGAAGACAGGAATCGAATGGCAAGAAATACCGCCCACGAATGGATCAGGAAGTCTCTGACCAAGCCATTAGCAGAGAATGAAGA
AGGAGAAAAACAGTCGGAAGCAGAAAATACTGAGCAAGTCAACAAAAATTCAATAGAGGATATCCATGCGTTTGCAATCCGGAGCCTGGC
TGAACTGACTGCCTGCTCAATTGAACTATTCCACAAAACAGCTGCATTGGTTCTGCATGGCAGGAAGCAGGAAGTGACAGCCATAGAAAG
GAGCCAAACTCTTTCCCAGATGACAATTGTGTTGTGTAAAGAGTTGTCCTCTCTGTCTAAAGAGTTCACTACCTGCCTAACAACTGCTGG
GGTCAAAGAAATGGCAGATGTCCTTAACCCATTAATCACTGCAGTATTTCTAGAGGCATCAAACAGTGCCTCCTACATCCAGGACGCCTT
TCAGCTACTCTTACCTGTGCTAGAGATCTCTCTCATTGAGAACAAGATTGAATCACACAGACATGAGCTGCAGGGCCAGAAACCTTTGTT
AGAACATTGAAGAATGGAGACGTTTTGACCTGGGACTTGTGACGGCCAAGGAATGCCACCTTATTCTGGCTACTCCTGCAGAAATGAAGG
AGTGGGGTTATTTTAGTATATAAAAATTCAGGCAGGAGAGATGGTTTAAAGAGGAAGATTGTTGCCTTCAGTGTTTGATTGAAGTATTCA
GGTTCTCACAGTATTCTTTCCAGTTGTTGTAATTCATAAATTATTTGAAAAGAAACTTTTGTAGAAAGTCCAAGAATAATAACTCTAGAT
AAAGATTAGTGGGACACTCAGGCAAAAATGTTGGTCTTTCTTTGACATGTTGCAAAATGTTATCAATTTTGTCATGGATATAATTTGCAG
CCCATGGATATAACTGGTTGATAAGCCAGAGAAAAATAATTTAGTGTTCTAAAATTCATGGCATGTGTGGTTTATTAATGCCATGTACTT
TCTCCTTTCTGGAATAAAATCTATGGCTTTAAGAAAACTGAGCATATGTAAACTCTGTGATGATTACCCTTTATCACATGAATTCTTGGA
AATAGAAAGTTTCATCTGCTTTTTTAAATTCTTAGTAGATATTTGGCATTGAGGAGAAACTTGTAGACTATTATAGCCATGTGAATTAAC
TGTAGCAAAGTGCCCTTTTTCTTCAAATTGCTCCCCCTCCCCAGGATGACACACTTCATGTCATAGCTGAACCCTACTCTACTGGATTCA
AGGCCAGTAAATGCAATTTAGAGAAGCAGTTTTATGTTTGCAGATATTCTGAGTCTCTTCAGGATGTGTTTCGTGTCTACCATATATGCA
GGATAAATTCTTTAACAGCAAACTCCAAAGGAATGTTGAAGCTGTTTTAGCAATGAGGATTTTTTTGTTTGAGTGTTGAAGTGGGCCATA
GTCCTTTAGAAATGATGTTCATTTATGATAGGATTTAACTTCTAAGGCATAGTTTATTTTTTCCTCTTTCCTTTTTGTTTGTTTTAATGT
ATTCTTTAGCATGTTTTTGATATAACTTTTATCCTCCAGATCTTAAGCTTTCTTTTGCTCTCTTCAGCAATTTAAGAGACTATTAAGCTG
TCGTCTTCCTAAAAGCTATTTTGGTATCCACTCTTTTTAAAAAAATTCTCCAACTTTGTGGTTTTTTAATGATTAAGGTAATTTGTTAGC
TCTGCCCCTCATCTTCTAAAACCTTTGTAATAAAATGTATTAATCATGTTATTTGATCCTTTCATTTACTTTTGTAAACACGAGCCCTAA
TATCTTACTTAGACCAAAAAAAAAAAAAAAAAATAGCAAAGCAAAGCCATAACATAGATTAGTATAAAGACTGTTTCTACGTAATCTTCT
TTGGGGCAGGAGTCAGTTAGTAAGCAAGGAAGAGAAATAAATTTGGTTTAAAAAGGTATACCAACAGCACTACAATGTTACTCTGCCTAT
ATTCTGTCTTAATATGATCAGAAAGTTTTTGAATATTCCTTTTTAAAGACAAATTTCACCCTTTCCAGCTTGAATATTTCTGAAGTTTCA
GAAAAACAGTTGCCTTCTGGTTACAAAGGCTGGTGTCACCAGTTCTGAATTGTTGCCTCAAGCTTGGTTGATGTGTCTGAACCTGTATCC
CTTGAGGGCAAAGTTTAGAAACTGGTCACTCTGCCTACTGTCTGTTCAGCCTCTTGTACAATGGCAGTTTGGCAGCTTTAAATCCTTAAC
CTAGAAATGTATTTAAGGTTTTTCTTTCAAGAAATGGGGTATACATATGAAGGAGAGAGTAACAACTCTTTTTATACACCTATTCAGATT
TCAGCCCTGAATTTGGCAAATTTTAGATTAGGTCTCACATAAGGTAAATATGACTCACTAACTCTTTTTTTCTCATCTTCCCCACCCCCC
CATATATATTTATTTATTTTAATGGAGTTAGGGACCACTAGTGAAATGATGAAAGGCCCAATTCTGAGTAACAATTGTCTACTCTTCACA
TAAAATATACTGAAAAAGAATTAAGATTCCTTGATCCAGTAGACATAGAGAAACATAAACATTCATGACAGATGAGTAGGTAAATTCAGG
GATCACTTTGGAACTTGCTGGATTATGGTGATGGTTTTTGGATAGTATGTGCTTCATTATTTTATTTGGGGTAGTTACAGTGTTTTAGTT
TTTTGTTAACAGCTACACTTTTGGTACTATTTTCCTTTTAAATTTTTGGTGTCTAAGATTTACCACTAATTACTAATATATGCCTTTCCA
ATTCACTTAAAACCTTAATAAGTGAAATGTTCAGGTATTGCTAGGGTAAATGTGTCTTTTCCTACTATTGAGATTTTAAAAGGCTGTGAT
TAAGAGAGACTTTATTAATTTGATCTGAAAGAAGTAGAAACCTCTATGAAACAATTTTTATTTTCCTTTGCATAATACCTTAGAAATGTG
TTAAGGACAAGCTATATTTTCCTTACTTGCTTTTGATAGTTTTTTTTTTTTTTTTTAAGCATAGATATCCAGGTTGGCAGGCCTCTGAAA
TGTGAAATTGTAATTTTTATAGATGGCATTACTATGAATCTGAAATCAGTGCTAGGTGTACAAATGTGAATTTTTCAATCCTGTAATCAA
AGAACAAGATCTTGTGGGTTCCTACTGCTGAAAAAGGATGCTTTCTTTTGTACTTGTTTTTAGTGAAAGACCTTTTTGAGGGAGAGCTAT
TTTATAGGTAGTTGCTATTGATATCTCCATTTGAGAAATAGACATTTTTCTGTATTTCTAGAGGTGTTCTGAATTTTAAACCTGAATTCT

>10124_10124_1_BRAF-FAM114A2_BRAF_chr7_140482821_ENST00000288602_FAM114A2_chr5_153382529_ENST00000351797_length(amino acids)=612AA_BP=438
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMARNTAHEWIRKS
LTKPLAENEEGEKQSEAENTEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSQTLSQMTIVLCKELSSLSK

--------------------------------------------------------------
>10124_10124_2_BRAF-FAM114A2_BRAF_chr7_140482821_ENST00000288602_FAM114A2_chr5_153382529_ENST00000520667_length(transcript)=2377nt_BP=1375nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCAT
TCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCA
TATAAACACAATAGAACCTGTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGC
TACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTC
ATCCTCAGAAGACAGGAATCGAATGGCAAGAAATACCGCCCACGAATGGATCAGGAAGTCTCTGACCAAGCCATTAGCAGAGAATGAAGA
AGGAGAAAAACAGTCGGAAGCAGAAAATACTGAGCAAGTCAACAAAAATTCAATAGAGGATATCCATGCGTTTGCAATCCGGAGCCTGGC
TGAACTGACTGCCTGCTCAATTGAACTATTCCACAAAACAGCTGCATTGGTTCTGCATGGCAGGAAGCAGGAAGTGACAGCCATAGAAAG
GAGCCAAACTCTTTCCCAGATGACAATTGTGTTGTGTAAAGAGTTGTCCTCTCTGTCTAAAGAGTTCACTACCTGCCTAACAACTGCTGG
GGTCAAAGAAATGGCAGATGTCCTTAACCCATTAATCACTGCAGTATTTCTAGAGGCATCAAACAGTGCCTCCTACATCCAGGACGCCTT
TCAGCTACTCTTACCTGTGCTAGAGATCTCTCTCATTGAGAACAAGATTGAATCACACAGACATGAGCTGCAGGGCCAGAAACCTTTGTT
AGAACATTGAAGAATGGAGACGTTTTGACCTGGGACTTGTGACGGCCAAGGAATGCCACCTTATTCTGGCTACTCCTGCAGAAATGAAGG
AGTGGGGTTATTTTAGTATATAAAAATTCAGGCAGGAGAGATGGTTTAAAGAGGAAGATTGTTGCCTTCAGTGTTTGATTGAAGTATTCA
GGTTCTCACAGTATTCTTTCCAGTTGTTGTAATTCATAAATTATTTGAAAAGAAACTTTTGTAGAAAGTCCAAGAATAATAACTCTAGAT
AAAGATTAGTGGGACACTCAGGCAAAAATGTTGGTCTTTCTTTGACATGTTGCAAAATGTTATCAATTTTGTCATGGATATAATTTGCAG
CCCATGGATATAACTGGTTGATAAGCCAGAGAAAAATAATTTAGTGTTCTAAAATTCATGGCATGTGTGGTTTATTAATGCCATGTACTT

>10124_10124_2_BRAF-FAM114A2_BRAF_chr7_140482821_ENST00000288602_FAM114A2_chr5_153382529_ENST00000520667_length(amino acids)=612AA_BP=438
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMARNTAHEWIRKS
LTKPLAENEEGEKQSEAENTEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSQTLSQMTIVLCKELSSLSK

--------------------------------------------------------------
>10124_10124_3_BRAF-FAM114A2_BRAF_chr7_140482821_ENST00000288602_FAM114A2_chr5_153382529_ENST00000522858_length(transcript)=3173nt_BP=1375nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGG
GGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATT
GGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGT
GCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTT
CCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT
AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGA
AGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTT
TTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTG
TGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGAC
TGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCAT
TCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCA
TATAAACACAATAGAACCTGTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGC
TACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTC
ATCCTCAGAAGACAGGAATCGAATGGCAAGAAATACCGCCCACGAATGGATCAGGAAGTCTCTGACCAAGCCATTAGCAGAGAATGAAGA
AGGAGAAAAACAGTCGGAAGCAGAAAATACTGAGCAAGTCAACAAAAATTCAATAGAGGATATCCATGCGTTTGCAATCCGGAGCCTGGC
TGAACTGACTGCCTGCTCAATTGAACTATTCCACAAAACAGCTGCATTGGTTCTGCATGGCAGGAAGCAGGAAGTGACAGCCATAGAAAG
GAGCCAAACTCTTTCCCAGATGACAATTGTGTTGTGTAAAGAGTTGTCCTCTCTGTCTAAAGAGTTCACTACCTGCCTAACAACTGCTGG
GGTCAAAGAAATGGCAGATGTCCTTAACCCATTAATCACTGCAGTATTTCTAGAGGCATCAAACAGTGCCTCCTACATCCAGGACGCCTT
TCAGCTACTCTTACCTGTGCTAGAGATCTCTCTCATTGAGAACAAGATTGAATCACACAGACATGAGCTGCAGGGCCAGAAACCTTTGTT
AGAACATTGAAGAATGGAGACGTTTTGACCTGGGACTTGTGACGGCCAAGGAATGCCACCTTATTCTGGCTACTCCTGCAGAAATGAAGG
AGTGGGGTTATTTTAGTATATAAAAATTCAGGCAGGAGAGATGGTTTAAAGAGGAAGATTGTTGCCTTCAGTGTTTGATTGAAGTATTCA
GGTTCTCACAGTATTCTTTCCAGTTGTTGTAATTCATAAATTATTTGAAAAGAAACTTTTGTAGAAAGTCCAAGAATAATAACTCTAGAT
AAAGATTAGTGGGACACTCAGGCAAAAATGTTGGTCTTTCTTTGACATGTTGCAAAATGTTATCAATTTTGTCATGGATATAATTTGCAG
CCCATGGATATAACTGGTTGATAAGCCAGAGAAAAATAATTTAGTGTTCTAAAATTCATGGCATGTGTGGTTTATTAATGCCATGTACTT
TCTCCTTTCTGGAATAAAATCTATGGCTTTAAGAAAACTGAGCATATGTAAACTCTGTGATGATTACCCTTTATCACATGAATTCTTGGA
AATAGAAAGTTTCATCTGCTTTTTTAAATTCTTAGTAGATATTTGGCATTGAGGAGAAACTTGTAGACTATTATAGCCATGTGAATTAAC
TGTAGCAAAGTGCCCTTTTTCTTCAAATTGCTCCCCCTCCCCAGGATGACACACTTCATGTCATAGCTGAACCCTACTCTACTGGATTCA
AGGCCAGTAAATGCAATTTAGAGAAGCAGTTTTATGTTTGCAGATATTCTGAGTCTCTTCAGGATGTGTTTCGTGTCTACCATATATGCA
GGATAAATTCTTTAACAGCAAACTCCAAAGGAATGTTGAAGCTGTTTTAGCAATGAGGATTTTTTTGTTTGAGTGTTGAAGTGGGCCATA
GTCCTTTAGAAATGATGTTCATTTATGATAGGATTTAACTTCTAAGGCATAGTTTATTTTTTCCTCTTTCCTTTTTGTTTGTTTTAATGT
ATTCTTTAGCATGTTTTTGATATAACTTTTATCCTCCAGATCTTAAGCTTTCTTTTGCTCTCTTCAGCAATTTAAGAGACTATTAAGCTG
TCGTCTTCCTAAAAGCTATTTTGGTATCCACTCTTTTTAAAAAAATTCTCCAACTTTGTGGTTTTTTAATGATTAAGGTAATTTGTTAGC
TCTGCCCCTCATCTTCTAAAACCTTTGTAATAAAATGTATTAATCATGTTATTTGATCCTTTCATTTACTTTTGTAAACACGAGCCCTAA

>10124_10124_3_BRAF-FAM114A2_BRAF_chr7_140482821_ENST00000288602_FAM114A2_chr5_153382529_ENST00000522858_length(amino acids)=612AA_BP=438
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLD
ALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQ
RCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMARNTAHEWIRKS
LTKPLAENEEGEKQSEAENTEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSQTLSQMTIVLCKELSSLSK

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Fusion Gene PPI Analysis for BRAF-FAM114A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRAF-FAM114A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRAF-FAM114A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource