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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ZKSCAN7-ZNF234 (FusionGDB2 ID:101265)

Fusion Gene Summary for ZKSCAN7-ZNF234

check button Fusion gene summary
Fusion gene informationFusion gene name: ZKSCAN7-ZNF234
Fusion gene ID: 101265
HgeneTgene
Gene symbol

ZKSCAN7

ZNF234

Gene ID

55888

10780

Gene namezinc finger with KRAB and SCAN domains 7zinc finger protein 234
SynonymsZFP|ZNF167|ZNF448|ZNF64|ZSCAN39HZF4|ZNF269
Cytomap

3p21.31

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein with KRAB and SCAN domains 7zinc finger protein 167zinc finger protein 448zinc finger protein 64zinc finger protein 234C2-H2 type zinc finger proteinHomo sapiens zinc finger 234zinc finger protein 234, partial sequencezinc finger protein 269zinc finger protein 4zinc finger protein HZF4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000273320, ENST00000426540, 
ENST00000341840, ENST00000431636, 
ENST00000590748, ENST00000426739, 
ENST00000592437, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: ZKSCAN7 [Title/Abstract] AND ZNF234 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZKSCAN7(44611831)-ZNF234(44661254), # samples:1
Anticipated loss of major functional domain due to fusion event.ZKSCAN7-ZNF234 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZKSCAN7-ZNF234 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZKSCAN7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF234 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC496574ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+


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Fusion Gene ORF analysis for ZKSCAN7-ZNF234

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000273320ENST00000590748ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
5CDS-intronENST00000426540ENST00000590748ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
Frame-shiftENST00000273320ENST00000426739ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
Frame-shiftENST00000426540ENST00000426739ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
Frame-shiftENST00000426540ENST00000592437ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
In-frameENST00000273320ENST00000592437ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
intron-3CDSENST00000341840ENST00000426739ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
intron-3CDSENST00000341840ENST00000592437ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
intron-3CDSENST00000431636ENST00000426739ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
intron-3CDSENST00000431636ENST00000592437ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
intron-intronENST00000341840ENST00000590748ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+
intron-intronENST00000431636ENST00000590748ZKSCAN7chr3

44611831

+ZNF234chr19

44661254

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273320ZKSCAN7chr344611831+ENST00000592437ZNF234chr1944661254+407730594291865478

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273320ENST00000592437ZKSCAN7chr344611831+ZNF234chr1944661254+0.0092652080.9907348

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Fusion Genomic Features for ZKSCAN7-ZNF234


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZKSCAN7-ZNF234


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:44611831/chr19:44661254)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF234chr3:44611831chr19:44661254ENST00000426739068_900701.0DomainKRAB
TgeneZNF234chr3:44611831chr19:44661254ENST00000592437068_900701.0DomainKRAB
TgeneZNF234chr3:44611831chr19:44661254ENST000004267390691_1470701.0RegionNote=KRNB
TgeneZNF234chr3:44611831chr19:44661254ENST000005924370691_1470701.0RegionNote=KRNB
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906148_1700701.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906176_1980701.0Zinc fingerC2H2-type 2
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906204_2260701.0Zinc fingerC2H2-type 3
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906232_2540701.0Zinc fingerC2H2-type 4
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906260_2820701.0Zinc fingerC2H2-type 5
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906288_3100701.0Zinc fingerC2H2-type 6
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906316_3380701.0Zinc fingerC2H2-type 7
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906344_3660701.0Zinc fingerC2H2-type 8
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906372_3940701.0Zinc fingerC2H2-type 9
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906400_4220701.0Zinc fingerC2H2-type 10
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906428_4500701.0Zinc fingerC2H2-type 11
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906456_4780701.0Zinc fingerC2H2-type 12
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906484_5060701.0Zinc fingerC2H2-type 13
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906512_5340701.0Zinc fingerC2H2-type 14
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906540_5620701.0Zinc fingerC2H2-type 15
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906568_5900701.0Zinc fingerC2H2-type 16
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906596_6180701.0Zinc fingerC2H2-type 17
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906624_6460701.0Zinc fingerC2H2-type 18
TgeneZNF234chr3:44611831chr19:44661254ENST0000042673906652_6740701.0Zinc fingerC2H2-type 19
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706148_1700701.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706176_1980701.0Zinc fingerC2H2-type 2
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706204_2260701.0Zinc fingerC2H2-type 3
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706232_2540701.0Zinc fingerC2H2-type 4
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706260_2820701.0Zinc fingerC2H2-type 5
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706288_3100701.0Zinc fingerC2H2-type 6
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706316_3380701.0Zinc fingerC2H2-type 7
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706344_3660701.0Zinc fingerC2H2-type 8
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706372_3940701.0Zinc fingerC2H2-type 9
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706400_4220701.0Zinc fingerC2H2-type 10
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706428_4500701.0Zinc fingerC2H2-type 11
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706456_4780701.0Zinc fingerC2H2-type 12
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706484_5060701.0Zinc fingerC2H2-type 13
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706512_5340701.0Zinc fingerC2H2-type 14
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706540_5620701.0Zinc fingerC2H2-type 15
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706568_5900701.0Zinc fingerC2H2-type 16
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706596_6180701.0Zinc fingerC2H2-type 17
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706624_6460701.0Zinc fingerC2H2-type 18
TgeneZNF234chr3:44611831chr19:44661254ENST0000059243706652_6740701.0Zinc fingerC2H2-type 19

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16231_3060755.0DomainKRAB
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+1654_1360755.0DomainSCAN box
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16231_3060277.0DomainKRAB
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+1654_1360277.0DomainSCAN box
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16231_3060755.0DomainKRAB
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+1654_1360755.0DomainSCAN box
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16231_3060277.0DomainKRAB
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+1654_1360277.0DomainSCAN box
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16383_4050755.0Zinc fingerC2H2-type 1
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16411_4330755.0Zinc fingerC2H2-type 2
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16439_4610755.0Zinc fingerC2H2-type 3
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16467_4890755.0Zinc fingerC2H2-type 4
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16495_5170755.0Zinc fingerC2H2-type 5
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16523_5450755.0Zinc fingerC2H2-type 6
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16551_5730755.0Zinc fingerC2H2-type 7
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16579_6010755.0Zinc fingerC2H2-type 8
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16607_6290755.0Zinc fingerC2H2-type 9
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16635_6570755.0Zinc fingerC2H2-type 10
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16663_6850755.0Zinc fingerC2H2-type 11%3B degenerate
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16691_7130755.0Zinc fingerC2H2-type 12
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000273320+16719_7410755.0Zinc fingerC2H2-type 13
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16383_4050277.0Zinc fingerC2H2-type 1
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16411_4330277.0Zinc fingerC2H2-type 2
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16439_4610277.0Zinc fingerC2H2-type 3
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16467_4890277.0Zinc fingerC2H2-type 4
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16495_5170277.0Zinc fingerC2H2-type 5
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16523_5450277.0Zinc fingerC2H2-type 6
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16551_5730277.0Zinc fingerC2H2-type 7
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16579_6010277.0Zinc fingerC2H2-type 8
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16607_6290277.0Zinc fingerC2H2-type 9
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16635_6570277.0Zinc fingerC2H2-type 10
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16663_6850277.0Zinc fingerC2H2-type 11%3B degenerate
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16691_7130277.0Zinc fingerC2H2-type 12
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000341840+16719_7410277.0Zinc fingerC2H2-type 13
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16383_4050755.0Zinc fingerC2H2-type 1
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16411_4330755.0Zinc fingerC2H2-type 2
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16439_4610755.0Zinc fingerC2H2-type 3
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16467_4890755.0Zinc fingerC2H2-type 4
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16495_5170755.0Zinc fingerC2H2-type 5
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16523_5450755.0Zinc fingerC2H2-type 6
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16551_5730755.0Zinc fingerC2H2-type 7
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16579_6010755.0Zinc fingerC2H2-type 8
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16607_6290755.0Zinc fingerC2H2-type 9
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16635_6570755.0Zinc fingerC2H2-type 10
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16663_6850755.0Zinc fingerC2H2-type 11%3B degenerate
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16691_7130755.0Zinc fingerC2H2-type 12
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000426540+16719_7410755.0Zinc fingerC2H2-type 13
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16383_4050277.0Zinc fingerC2H2-type 1
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16411_4330277.0Zinc fingerC2H2-type 2
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16439_4610277.0Zinc fingerC2H2-type 3
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16467_4890277.0Zinc fingerC2H2-type 4
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16495_5170277.0Zinc fingerC2H2-type 5
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16523_5450277.0Zinc fingerC2H2-type 6
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16551_5730277.0Zinc fingerC2H2-type 7
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16579_6010277.0Zinc fingerC2H2-type 8
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16607_6290277.0Zinc fingerC2H2-type 9
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16635_6570277.0Zinc fingerC2H2-type 10
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16663_6850277.0Zinc fingerC2H2-type 11%3B degenerate
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16691_7130277.0Zinc fingerC2H2-type 12
HgeneZKSCAN7chr3:44611831chr19:44661254ENST00000431636+16719_7410277.0Zinc fingerC2H2-type 13


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Fusion Gene Sequence for ZKSCAN7-ZNF234


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101265_101265_1_ZKSCAN7-ZNF234_ZKSCAN7_chr3_44611831_ENST00000273320_ZNF234_chr19_44661254_ENST00000592437_length(transcript)=4077nt_BP=3059nt
ATTGTTTTTGGTCTAACGGGCAGTAGAGTGTCCGGCTTCGGTGCCGAGTGCCACCGCGAGTGGGCCGAGACGCGGAGGGAGGCGCGGCCG
GAGCTCGGGTCGCCGACGCTGGCCAGGACCGCGCTTCTTCCCGGCGGCAGGCGGCGCGGTCCCCGTGACTCTCAGAAGCCGCCCGATGTA
GAGCCGCTTCTTTGTCTCATACCCCTGACCATTCGTGCGTGGCACGGAGCCGGGTATCTGCGGGTACAGCGATGAACAGGGCAGACGTGG
CCAGGTGAGCGGCGCTGCTGAAGCCTGGTTTAACACGAAAGGCCACACTACCATCACCCCTTTCTCCAACCCTGAAAAACAGTTCCTGAG
ACCTGAACTATTGACCATCATTTTAATCGGACCAACTGCAGCTGTAACAAGCTTCTCTTTGGGGTCACAATGACCACTGCAGGCAGGGGA
AATTTAGGCCTCATCCCCAGGAGCACTGCTTTCCAGAAGCAAGAGGGGCGCCTGACTGTGAAGCAGGAGCCAGCAAACCAGACCTGGGGG
CAGGGCAGCAGTCTCCAGAAGAACTATCCTCCTGTCTGCGAAATCTTCCGGCTACACTTCAGGCAATTGTGTTACCACGAGATGTCTGGG
CCGCAGGAAGCATTGAGCCGGCTTCGGGAGCTCTGCCGCTGGTGGCTCATGCCAGAGGTGCACACCAAGGAGCAGATCCTGGAGCTGCTG
GTGCTTGAGCAGTTCCTGAGCATCCTCCCTGGGGAGCTCCGGACCTGGGTGCAGCTGCATCACCCTGAGAGTGGTGAGGAGGCTGTGGCT
GTGGTGGAGGATTTCCAGAGACACCTCAGTGGATCAGAGGAGGTTTCAGCCCCAGCACAGAAACAGGAAATGCATTTTGAGGAGACAACA
GCTCTGGGTACAACAAAGGAATCTCCTCCTACCTCACCCCTCAGTGGGGGCTCAGCCCCTGGAGCCCACCTGGAGCCTCCTTATGACCCA
GGGACACACCACCTCCCCAGTGGGGACTTCGCTCAATGTACTTCTCCAGTTCCTACCCTTCCTCAAGTGGGGAACTCAGGAGACCAAGCA
GGGGCAACTGTACTTCGGATGGTCAGGCCCCAGGATACTGTGGCATATGAGGACCTATCTGTAGACTACACTCAGAAGAAATGGAAAAGT
CTCACACTCAGTCAGAGAGCCCTGCAGTGGAACATGATGCCAGAAAATCACCATAGCATGGCCTCCTTGGCTATGAGTGTAATGAGTGTG
GGAAGACCTTCAGGCAAACCTCCCAGCTCATTGTTCATCTCAGAACCCACACAGGGGAAAAACCCTATGAATGCAGTGAGTGTGGAAAGG
CCTATAGGCACAGCTCCCATCTCATTCAACACCAGAGACTCCATAATGGGGAGAAACCCTATAAATGTAATGAATGTGCAAAAGCCTTTA
CTCAGAGTTCCCGACTCACTGACCACCAGAGAACCCATACTGGGGAGAAACCTTATGAATGCAATGAGTGTGGAGAGGCATTCATTCGAA
GCAAAAGTCTTGCTCGACATCAGGTCCTGCACACTGGTAAGAAACCTTACAAATGCAATGAGTGTGGGAGAGCATTCTGTTCCAATAGAA
ATCTCATTGACCATCAGAGAATCCACACTGGGGAGAAGCCTTATGAGTGTAGTGAATGTGGCAAAGCCTTCAGTCGGAGTAAATGTCTTA
TTCGACATCAGAGCCTCCATACTGGGGAAAAGCCATACAAATGTAGTGAATGTGGGAAAGCCTTCAATCAGAACTCTCAACTCATTGAGC
ATGAGCGAATTCATACTGGAGAAAAACCTTTTGAATGTAGCGAGTGTGGTAAGGCATTTGGTCTGAGTAAATGTCTTATTCGGCACCAGA
GACTTCACACGGGTGAAAAGCCCTATAAATGCAATGAGTGTGGAAAATCCTTCAATCAAAACTCACACCTTATTATACACCAGAGAATTC
ACACTGGTGAGAAACCCTATGAATGTAATGAGTGTGGGAAGGTATTCAGTTATAGCTCCAGCCTTATGGTACATCAGAGAACCCATACTG
GGGAAAAACCCTATAAATGCAATGATTGTGGGAAAGCTTTTAGTGACAGCTCACAGCTTATTGTACACCAGAGAGTCCACACCGGAGAGA
AACCTTATGAATGTAGTGAATGTGGGAAAGCCTTTAGTCAGCGTTCCACTTTTAATCACCACCAGCGAACTCACACTGGAGAGAAGTCCT
CAGGTCTGGCTTGGTCAGTTTCTTAAGGTATGGTTCTCTGAGACAGAGAGCAACGACCTTTGAGTTAAGCTGTCTTTATAAGCAGGATGC
TCATAGTGGTTTCCCGGAGCCAGTAGTCACGGTGGACCATTCCCTACTTGCTTTTCCTTGGATCACTAAGGTGGGAGAGTAGGAGTAACT
TATTCCAGTTCTTACCCATTATTAGGAAGGTAAGGACTACACATGTCATTGAATTGTAGGTTTCCTTTTTTTTTCTTTACTTTTAAATTT
TAACTTTTAAAATCTATTTCATTTCTTAGTTATGCATCTCATAATCAGACTCCATGCTTTTTAAAGACAGAGATAATATCTTCTCTATTC
TATTCTACTTCCTCCATTTCACCATTTATACAAAGTCATTCAAAAAGGCTGATTCATGCCTTCCTGCCTCTTGGCTATGGCCCTCCCCAT
CTACTCTTTAAACTTTAATCTATAACTTTTCATCAGTTTTGTTCCCTATCTAGAAAACATTTTCTTCTGTTTGCTAATCTTTGTCCCTCA
CAATTTTTGAAATCCATCTCATCACTGAAATACTTTCTTCTTCAAGTACTTTTTTATTTTTCTTCAACTTCTCTTGATTTGACCTCAGTG
CTTTGAATTCACTGGTGCTACAATATGTAACTGTGGTTAATTGCCTTGTAAATTTTGCGTGTCTGTATACTTTTATACCAACTTATTGTA
GGCTCTTTGAGGTCAGGTATGTATTTCTTTCCCATATAGATAGTATTTTGTACATACCAGTTGTTAAATAAATAATTTTTAAAATCTCAT
CGGAGAATCCACACTGGAGAGAAACCATACGTATGTAAAGTGTGTGGTAAGGGTTTCATTTACAGTTCAAGTTTTCAGGCCCATCAGGGA
GTCCACACTGGAGAGAAGCCATACAAATGCAATGAGTGTGGGAAGAGCTTCAGAATGAAAATTCATTATCAAGTGCATCTGGTAGTCCAC
ACAGGGGAAAAACCCTATAAATGTGAAGTATGTGGTAAAGCCTTCCGTCAGAGTTCATATCTTAAAATCCATCTGAAAGCACATAGTGTA
CAGAAACCTTTTAAGTGTGAAGAGTGTGGGCAGGGCTTCAATCAGAGCTCACGACTTCAGATTCACCAGCTGATCCATACCGGTGAGAAA
CCATACAAATGTGAAGAGTGCGGAAAGGGATTTAGTCGTAGAGCAGATCTTAAAATTCATTGTAGGATCCACACAGGGGAGAAACCATAT
AATTGTGAGGAGTGTGGGAAGGTCTTCAGTCAGGCCTCGCATCTTCTAACCCATCAGAGAGTTCACAGTGGGGAAAAACCATTTAAATGT
GAAGAGTGTGGGAAGAGCTTCAGTCGGAGTGCACACCTTCAAGCCCATCAAAAAGTCCACACTGGAGAAAAGCCATACAAATGTGGGGAG
TGTGGAAAGGGCTTCAAGTGGAGCTTGAACCTTGACATGCATCAGAGGGTGCACACAGGAGAAAAACCCTATACATGTGGGGAGTGTGGG
AAGCACTTCAGTCAGGCCTCAAGTCTCCAACTTCATCAGAGTGTCCACACAGGAGAGAAACCATACAAATGTGATGTATGTGGTAAAGTC
TTCAGTCGGTCTTCACAATTACAGTATCATAGGCGAGTTCACACTGGGGAAAAACCTTACAAATGTGAGATATGTGGTAAGAGGTTCAGC
TGGCGATCAAATCTTGTAAGTCATCACAAAATTCATGCTGCTGGTACATTTTATGAAAATGATGAGAATAGTAAGAACATCAGAGAGTTG

>101265_101265_1_ZKSCAN7-ZNF234_ZKSCAN7_chr3_44611831_ENST00000273320_ZNF234_chr19_44661254_ENST00000592437_length(amino acids)=478AA_BP=349
MTTAGRGNLGLIPRSTAFQKQEGRLTVKQEPANQTWGQGSSLQKNYPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTK
EQILELLVLEQFLSILPGELRTWVQLHHPESGEEAVAVVEDFQRHLSGSEEVSAPAQKQEMHFEETTALGTTKESPPTSPLSGGSAPGAH
LEPPYDPGTHHLPSGDFAQCTSPVPTLPQVGNSGDQAGATVLRMVRPQDTVAYEDLSVDYTQKKWKSLTLSQRALQWNMMPENHHSMASL
AMSVMSVGRPSGKPPSSLFISEPTQGKNPMNAVSVERPIGTAPISFNTRDSIMGRNPINVMNVQKPLLRVPDSLTTREPILGRNLMNAMS
VERHSFEAKVLLDIRSCTLVRNLTNAMSVGEHSVPIEISLTIRESTLGRSLMSVVNVAKPSVGVNVLFDIRASILGKSHTNVVNVGKPSI

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Fusion Gene PPI Analysis for ZKSCAN7-ZNF234


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZKSCAN7-ZNF234


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZKSCAN7-ZNF234


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource