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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZMAT5-HIRA (FusionGDB2 ID:101285)

Fusion Gene Summary for ZMAT5-HIRA

Fusion gene summary

Fusion gene information	Fusion gene name: ZMAT5-HIRA
	Fusion gene ID: 101285
		Hgene	Tgene
	Gene symbol	ZMAT5	HIRA
	Gene ID	55954	7290
	Gene name	zinc finger matrin-type 5	histone cell cycle regulator
	Synonyms	SNRNP20\|U11/U12-20K\|ZC3H19	DGCR1\|TUP1\|TUPLE1
	Cytomap	22q12.2	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	zinc finger matrin-type protein 5U11/U12 small nuclear ribonucleoprotein 20 kDa proteinU11/U12 snRNP 20 kDa proteinU11/U12 snRNP 20Kzinc finger CCCH-type containing 19	protein HIRADiGeorge critical region gene 1HIR histone cell cycle regulation defective homolog ATUP1-like enhancer of split protein 1histone regulator A
	Modification date	20200313	20200313
	UniProtAcc	.	P54198
	Ensembl transtripts involved in fusion gene	ENST00000344318, ENST00000397781,	ENST00000464189, ENST00000546308, ENST00000340170, ENST00000541063, ENST00000263208,
Fusion gene scores	* DoF score	7 X 8 X 6=336	7 X 6 X 4=168
	# samples	10	7
	** MAII score	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZMAT5 [Title/Abstract] AND HIRA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZMAT5(30134319)-HIRA(19319079), # samples:3
Anticipated loss of major functional domain due to fusion event.	ZMAT5-HIRA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ZMAT5-HIRA seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. ZMAT5-HIRA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ZMAT5-HIRA seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HIRA	GO:0006336	DNA replication-independent nucleosome assembly	14718166

Fusion gene breakpoints across ZMAT5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HIRA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8048-01A	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
ChimerDB4	LUSC	TCGA-85-8048	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-

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Fusion Gene ORF analysis for ZMAT5-HIRA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000344318	ENST00000464189	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
5CDS-intron	ENST00000344318	ENST00000546308	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
5CDS-intron	ENST00000397781	ENST00000464189	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
5CDS-intron	ENST00000397781	ENST00000546308	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
Frame-shift	ENST00000344318	ENST00000340170	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
Frame-shift	ENST00000344318	ENST00000541063	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
Frame-shift	ENST00000397781	ENST00000263208	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
In-frame	ENST00000344318	ENST00000263208	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
In-frame	ENST00000397781	ENST00000340170	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-
In-frame	ENST00000397781	ENST00000541063	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000344318	ZMAT5	chr22	30134319	-	ENST00000263208	HIRA	chr22	19319079	-	1359	500	117	524	135
ENST00000397781	ZMAT5	chr22	30134319	-	ENST00000340170	HIRA	chr22	19319079	-	1493	634	251	658	135
ENST00000397781	ZMAT5	chr22	30134319	-	ENST00000541063	HIRA	chr22	19319079	-	1133	634	251	658	135

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000344318	ENST00000263208	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-	0.029824598	0.9701754
ENST00000397781	ENST00000340170	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-	0.03842278	0.9615772
ENST00000397781	ENST00000541063	ZMAT5	chr22	30134319	-	HIRA	chr22	19319079	-	0.015744934	0.9842551

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Fusion Genomic Features for ZMAT5-HIRA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZMAT5-HIRA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:30134319/chr22:19319079)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HIRA P54198
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269\|PubMed:12370293, ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:15621527}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZMAT5

chr22:30134319

chr22:19319079

ENST00000344318

51_79

127

171.0

Zinc finger

C3H1-type

Hgene

ZMAT5

chr22:30134319

chr22:19319079

ENST00000397781

51_79

127

171.0

Zinc finger

C3H1-type

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

805_808

772

811.0

Compositional bias

Note=Poly-Val

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

408_412

979

1018.0

Compositional bias

Note=Poly-Gln

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

640_643

979

1018.0

Compositional bias

Note=Poly-Lys

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

805_808

979

1018.0

Compositional bias

Note=Poly-Val

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

408_412

772

811.0

Compositional bias

Note=Poly-Gln

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

640_643

772

811.0

Compositional bias

Note=Poly-Lys

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

439_475

979

1018.0

Region

Note=Required for repression of histone gene transcription

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

439_475

772

811.0

Region

Note=Required for repression of histone gene transcription

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

11_53

979

1018.0

Repeat

Note=WD 1

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

129_168

979

1018.0

Repeat

Note=WD 3

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

172_211

979

1018.0

Repeat

Note=WD 4

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

220_263

979

1018.0

Repeat

Note=WD 5

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

266_322

979

1018.0

Repeat

Note=WD 6

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

326_367

979

1018.0

Repeat

Note=WD 7

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000263208

68_107

979

1018.0

Repeat

Note=WD 2

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

11_53

772

811.0

Repeat

Note=WD 1

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

129_168

772

811.0

Repeat

Note=WD 3

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

172_211

772

811.0

Repeat

Note=WD 4

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

220_263

772

811.0

Repeat

Note=WD 5

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

266_322

772

811.0

Repeat

Note=WD 6

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

326_367

772

811.0

Repeat

Note=WD 7

Tgene

HIRA

chr22:30134319

chr22:19319079

ENST00000340170

68_107

772

811.0

Repeat

Note=WD 2

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Fusion Gene Sequence for ZMAT5-HIRA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>101285_101285_1_ZMAT5-HIRA_ZMAT5_chr22_30134319_ENST00000344318_HIRA_chr22_19319079_ENST00000263208_length(transcript)=1359nt_BP=500nt
ACCGGGGAGCCAGGTACCTTCCGCGAGACGTCGAGGGGCGAGTCCTAGTCTCTTTTCTCCGCACTGGAAGACTTGAACACTTCCTTCTCT
GCAGCAAAGCACCTGCTCTGAGTGGCCATGGGGAAGCGATACTTCTGTGACTACTGCGACCGCTCCTTCCAGGACAACCTCCACAACCGC
AAGAAGCACCTGAACGGGCTGCAGCACCTCAAGGCCAAGAAGGTCTGGTACGACATGTTCCGAGATGCAGCTGCCATCTTGCTGGATGAG
CAGAACAAGCGGCCCTGCAGGAAGTTTCTACTGACAGGCCAGTGCGACTTTGGCTCCAACTGCAGATTTTCCCACATGTCAGAGCGAGAC
CTGCAGGAGCTGAGCATCCAGGTGGAGGAGGAGAGGCGAGCCAGGGAGTGGCTACTAGATGCTCCTGAGCTCCCCGAGGGCCATCTGGAG
GACTGGCTGGAGAAGAGAGCCAAGCGGCTGAGCTCAGCCCCAAGTAGCAGGGTCTGCGGAAGAGGGAGCTGCTGAAGGAGCTGCTACCAG
TCATCGGGCAGAACCTCCGATTCCAGCGCCTCTTCACCGAGTGTCAGGAACAGCTCGACATCCTGAGGGACAAGTAGCCTGCCCCAGCCT
GCCCTGGCTGCAGCAAGGGCAGGGCCACACTCTCGCCGCTGATGACATGCAGGACCGCCTCTCACCTGACCAGGCTGTAGGGGGAGGAGA
CACTGGCAGGAGATGTGCTGTCCTGCACCAGCGCCAGCCCAGCTCCCTGGGCAGATGTGCCCTGTGTCCTGGGTCTGACATTGCCTCAGG
AGGGGGAAGCTCATCCCTCCCTCCAAGCCCCCGATGCGGAGCTAGGGCTGGAGCTCTGCCCAGGTGCCCTGGGGCCAGCAAGGCAGTCCC
AGGCCTGCCGTCTCCAGCACGGCCCCAAGGTGGACACTAGCCCCTGCTGCTGCAGGCACCATGCTGCTTCAGCAGTGACGATTGAGCCAT
TTGTGAGAGAGAATCCGGAAGCGTTAGGTATTACAGCAGACTGACCTAAGACCTATGTAAAAGGAAAGCTGTTCCAACACACGGACTATT
TTTGTACTAGAATTTGCTAACTTGTAATATTGAATTTCCTTTGGCCGATAATCAGGATTTCCCTATAAGTCACTTGGACATTGGTCACTT
GTAGGAAATTTAAACTCTAATTATGACAGCTACACTGAAAAATAATTGTACTGAAATTAACTTGTCTATCTTCATTTGGTTTTAATTTTT
AAATGTTTGTAAAAAGAGACTGTTTTGGGGGAATGGGGCAAAGGGGTGGGCGATTTCTTTTGTAAGTGTAAAATAAATGAACACGCATTG

>101285_101285_1_ZMAT5-HIRA_ZMAT5_chr22_30134319_ENST00000344318_HIRA_chr22_19319079_ENST00000263208_length(amino acids)=135AA_BP=
MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKVWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSIQVE

--------------------------------------------------------------
>101285_101285_2_ZMAT5-HIRA_ZMAT5_chr22_30134319_ENST00000397781_HIRA_chr22_19319079_ENST00000340170_length(transcript)=1493nt_BP=634nt
GGAGCCCGGAGCTGCAGCCACCGGGGAGCCAGGTACCTTCCGCGAGACGTCGAGGGGCGAGTCCTAGTCTCTTTTCTCCGCACTGGAAGA
CTTGAACACTTCCTTCTCTGGTCTCTGTCACCCAGGCTGGAGTGTAGTGGCGCAATCTCAGCTGGCTGGAGCCTTGACCTCCTTGGGCTC
AAGCTATCCTCCCACCTCAGCCTCTCAAATAGCTGGGACTACAGGCAGCAAAGCACCTGCTCTGAGTGGCCATGGGGAAGCGATACTTCT
GTGACTACTGCGACCGCTCCTTCCAGGACAACCTCCACAACCGCAAGAAGCACCTGAACGGGCTGCAGCACCTCAAGGCCAAGAAGGTCT
GGTACGACATGTTCCGAGATGCAGCTGCCATCTTGCTGGATGAGCAGAACAAGCGGCCCTGCAGGAAGTTTCTACTGACAGGCCAGTGCG
ACTTTGGCTCCAACTGCAGATTTTCCCACATGTCAGAGCGAGACCTGCAGGAGCTGAGCATCCAGGTGGAGGAGGAGAGGCGAGCCAGGG
AGTGGCTACTAGATGCTCCTGAGCTCCCCGAGGGCCATCTGGAGGACTGGCTGGAGAAGAGAGCCAAGCGGCTGAGCTCAGCCCCAAGTA
GCAGGGTCTGCGGAAGAGGGAGCTGCTGAAGGAGCTGCTACCAGTCATCGGGCAGAACCTCCGATTCCAGCGCCTCTTCACCGAGTGTCA
GGAACAGCTCGACATCCTGAGGGACAAGTAGCCTGCCCCAGCCTGCCCTGGCTGCAGCAAGGGCAGGGCCACACTCTCGCCGCTGATGAC
ATGCAGGACCGCCTCTCACCTGACCAGGCTGTAGGGGGAGGAGACACTGGCAGGAGATGTGCTGTCCTGCACCAGCGCCAGCCCAGCTCC
CTGGGCAGATGTGCCCTGTGTCCTGGGTCTGACATTGCCTCAGGAGGGGGAAGCTCATCCCTCCCTCCAAGCCCCCGATGCGGAGCTAGG
GCTGGAGCTCTGCCCAGGTGCCCTGGGGCCAGCAAGGCAGTCCCAGGCCTGCCGTCTCCAGCACGGCCCCAAGGTGGACACTAGCCCCTG
CTGCTGCAGGCACCATGCTGCTTCAGCAGTGACGATTGAGCCATTTGTGAGAGAGAATCCGGAAGCGTTAGGTATTACAGCAGACTGACC
TAAGACCTATGTAAAAGGAAAGCTGTTCCAACACACGGACTATTTTTGTACTAGAATTTGCTAACTTGTAATATTGAATTTCCTTTGGCC
GATAATCAGGATTTCCCTATAAGTCACTTGGACATTGGTCACTTGTAGGAAATTTAAACTCTAATTATGACAGCTACACTGAAAAATAAT
TGTACTGAAATTAACTTGTCTATCTTCATTTGGTTTTAATTTTTAAATGTTTGTAAAAAGAGACTGTTTTGGGGGAATGGGGCAAAGGGG

>101285_101285_2_ZMAT5-HIRA_ZMAT5_chr22_30134319_ENST00000397781_HIRA_chr22_19319079_ENST00000340170_length(amino acids)=135AA_BP=
MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKVWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSIQVE

--------------------------------------------------------------
>101285_101285_3_ZMAT5-HIRA_ZMAT5_chr22_30134319_ENST00000397781_HIRA_chr22_19319079_ENST00000541063_length(transcript)=1133nt_BP=634nt
GGAGCCCGGAGCTGCAGCCACCGGGGAGCCAGGTACCTTCCGCGAGACGTCGAGGGGCGAGTCCTAGTCTCTTTTCTCCGCACTGGAAGA
CTTGAACACTTCCTTCTCTGGTCTCTGTCACCCAGGCTGGAGTGTAGTGGCGCAATCTCAGCTGGCTGGAGCCTTGACCTCCTTGGGCTC
AAGCTATCCTCCCACCTCAGCCTCTCAAATAGCTGGGACTACAGGCAGCAAAGCACCTGCTCTGAGTGGCCATGGGGAAGCGATACTTCT
GTGACTACTGCGACCGCTCCTTCCAGGACAACCTCCACAACCGCAAGAAGCACCTGAACGGGCTGCAGCACCTCAAGGCCAAGAAGGTCT
GGTACGACATGTTCCGAGATGCAGCTGCCATCTTGCTGGATGAGCAGAACAAGCGGCCCTGCAGGAAGTTTCTACTGACAGGCCAGTGCG
ACTTTGGCTCCAACTGCAGATTTTCCCACATGTCAGAGCGAGACCTGCAGGAGCTGAGCATCCAGGTGGAGGAGGAGAGGCGAGCCAGGG
AGTGGCTACTAGATGCTCCTGAGCTCCCCGAGGGCCATCTGGAGGACTGGCTGGAGAAGAGAGCCAAGCGGCTGAGCTCAGCCCCAAGTA
GCAGGGTCTGCGGAAGAGGGAGCTGCTGAAGGAGCTGCTACCAGTCATCGGGCAGAACCTCCGATTCCAGCGCCTCTTCACCGAGTGTCA
GGAACAGCTCGACATCCTGAGGGACAAGTAGCCTGCCCCAGCCTGCCCTGGCTGCAGCAAGGGCAGGGCCACACTCTCGCCGCTGATGAC
ATGCAGGACCGCCTCTCACCTGACCAGGCTGTAGGGGGAGGAGACACTGGCAGGAGATGTGCTGTCCTGCACCAGCGCCAGCCCAGCTCC
CTGGGCAGATGTGCCCTGTGTCCTGGGTCTGACATTGCCTCAGGAGGGGGAAGCTCATCCCTCCCTCCAAGCCCCCGATGCGGAGCTAGG
GCTGGAGCTCTGCCCAGGTGCCCTGGGGCCAGCAAGGCAGTCCCAGGCCTGCCGTCTCCAGCACGGCCCCAAGGTGGACACTAGCCCCTG

>101285_101285_3_ZMAT5-HIRA_ZMAT5_chr22_30134319_ENST00000397781_HIRA_chr22_19319079_ENST00000541063_length(amino acids)=135AA_BP=
MGKRYFCDYCDRSFQDNLHNRKKHLNGLQHLKAKKVWYDMFRDAAAILLDEQNKRPCRKFLLTGQCDFGSNCRFSHMSERDLQELSIQVE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZMAT5-HIRA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000263208		23	25	421_479	979.0	1018.0	ASF1A
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000340170		19	21	421_479	772.0	811.0	ASF1A
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000263208		23	25	421_729	979.0	1018.0	CCNA1
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000340170		19	21	421_729	772.0	811.0	CCNA1
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000263208		23	25	593_826	979.0	1018.0	histone H2B
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000340170		19	21	593_826	772.0	811.0	histone H2B
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000263208		23	25	738_1017	979.0	1018.0	histone H4
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000340170		19	21	738_1017	772.0	811.0	histone H4
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000263208		23	25	594_739	979.0	1018.0	PAX3
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000263208		23	25	740_828	979.0	1018.0	PAX3
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000340170		19	21	594_739	772.0	811.0	PAX3
Tgene	HIRA	chr22:30134319	chr22:19319079	ENST00000340170		19	21	740_828	772.0	811.0	PAX3

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZMAT5-HIRA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZMAT5-HIRA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source