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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZMYM2-MTIF3 (FusionGDB2 ID:101347)

Fusion Gene Summary for ZMYM2-MTIF3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYM2-MTIF3
Fusion gene ID: 101347
HgeneTgene
Gene symbol

ZMYM2

MTIF3

Gene ID

7750

219402

Gene namezinc finger MYM-type containing 2mitochondrial translational initiation factor 3
SynonymsFIM|MYM|RAMP|SCLL|ZNF198IF3mt
Cytomap

13q12.11

13q12.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 2fused in myeloproliferative disorders proteinrearranged in an atypical myeloproliferative disorderzinc finger protein 198zinc finger, MYM-type 2translation initiation factor IF-3, mitochondrialIF-3(Mt)
Modification date2020031320200320
UniProtAcc.

Q9H2K0

Ensembl transtripts involved in fusion geneENST00000382869, ENST00000382871, 
ENST00000382874, ENST00000382881, 
ENST00000382883, ENST00000494061, 
ENST00000461838, ENST00000381116, 
ENST00000381120, ENST00000405591, 
ENST00000431572, 
Fusion gene scores* DoF score19 X 16 X 11=33444 X 4 X 4=64
# samples 215
** MAII scorelog2(21/3344*10)=-3.99311361441476
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZMYM2 [Title/Abstract] AND MTIF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYM2(20580726)-MTIF3(28010030), # samples:1
Anticipated loss of major functional domain due to fusion event.ZMYM2-MTIF3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ZMYM2-MTIF3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZMYM2-MTIF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTIF3

GO:0032790

ribosome disassembly

12095986

TgeneMTIF3

GO:0070124

mitochondrial translational initiation

12095986


check buttonFusion gene breakpoints across ZMYM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTIF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A49KZMYM2chr13

20580726

+MTIF3chr13

28010030

-


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Fusion Gene ORF analysis for ZMYM2-MTIF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000382869ENST00000461838ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
5CDS-5UTRENST00000382871ENST00000461838ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
5CDS-5UTRENST00000382874ENST00000461838ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
5CDS-5UTRENST00000382881ENST00000461838ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382869ENST00000381116ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382869ENST00000381120ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382869ENST00000405591ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382871ENST00000381116ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382871ENST00000381120ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382871ENST00000405591ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382874ENST00000381116ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382874ENST00000381120ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382874ENST00000405591ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382881ENST00000381116ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382881ENST00000381120ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
Frame-shiftENST00000382881ENST00000405591ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
In-frameENST00000382869ENST00000431572ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
In-frameENST00000382871ENST00000431572ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
In-frameENST00000382874ENST00000431572ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
In-frameENST00000382881ENST00000431572ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000382883ENST00000381116ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000382883ENST00000381120ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000382883ENST00000405591ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000382883ENST00000431572ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000494061ENST00000381116ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000494061ENST00000381120ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000494061ENST00000405591ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-3CDSENST00000494061ENST00000431572ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-5UTRENST00000382883ENST00000461838ZMYM2chr13

20580726

+MTIF3chr13

28010030

-
intron-5UTRENST00000494061ENST00000461838ZMYM2chr13

20580726

+MTIF3chr13

28010030

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000382869ZMYM2chr1320580726+ENST00000431572MTIF3chr1328010030-201817631971981594
ENST00000382881ZMYM2chr1320580726+ENST00000431572MTIF3chr1328010030-175014951901713507
ENST00000382874ZMYM2chr1320580726+ENST00000431572MTIF3chr1328010030-195717021901920576
ENST00000382871ZMYM2chr1320580726+ENST00000431572MTIF3chr1328010030-195216971851915576

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382869ENST00000431572ZMYM2chr1320580726+MTIF3chr1328010030-0.0003424160.99965763
ENST00000382881ENST00000431572ZMYM2chr1320580726+MTIF3chr1328010030-0.0003892040.99961084
ENST00000382874ENST00000431572ZMYM2chr1320580726+MTIF3chr1328010030-0.0003574710.9996425
ENST00000382871ENST00000431572ZMYM2chr1320580726+MTIF3chr1328010030-0.0003421680.99965787

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Fusion Genomic Features for ZMYM2-MTIF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZMYM2-MTIF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:20580726/chr13:28010030)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MTIF3

Q9H2K0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. {ECO:0000269|PubMed:12095986}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625352_3865041378.0Zinc fingerNote=MYM-type 1
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625398_4365041378.0Zinc fingerNote=MYM-type 2
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625445_4805041378.0Zinc fingerNote=MYM-type 3
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726352_3865041378.0Zinc fingerNote=MYM-type 1
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726398_4365041378.0Zinc fingerNote=MYM-type 2
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726445_4805041378.0Zinc fingerNote=MYM-type 3
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726352_3865041378.0Zinc fingerNote=MYM-type 1
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726398_4365041378.0Zinc fingerNote=MYM-type 2
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726445_4805041378.0Zinc fingerNote=MYM-type 3
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78352_386417463.0Zinc fingerNote=MYM-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625491_5495041378.0Zinc fingerNote=MYM-type 4
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625559_5975041378.0Zinc fingerNote=MYM-type 5
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625605_6525041378.0Zinc fingerNote=MYM-type 6
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625660_6945041378.0Zinc fingerNote=MYM-type 7
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625701_7405041378.0Zinc fingerNote=MYM-type 8
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382869+625747_7815041378.0Zinc fingerNote=MYM-type 9
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726491_5495041378.0Zinc fingerNote=MYM-type 4
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726559_5975041378.0Zinc fingerNote=MYM-type 5
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726605_6525041378.0Zinc fingerNote=MYM-type 6
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726660_6945041378.0Zinc fingerNote=MYM-type 7
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726701_7405041378.0Zinc fingerNote=MYM-type 8
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382871+726747_7815041378.0Zinc fingerNote=MYM-type 9
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726491_5495041378.0Zinc fingerNote=MYM-type 4
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726559_5975041378.0Zinc fingerNote=MYM-type 5
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726605_6525041378.0Zinc fingerNote=MYM-type 6
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726660_6945041378.0Zinc fingerNote=MYM-type 7
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726701_7405041378.0Zinc fingerNote=MYM-type 8
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382874+726747_7815041378.0Zinc fingerNote=MYM-type 9
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78398_436417463.0Zinc fingerNote=MYM-type 2
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78445_480417463.0Zinc fingerNote=MYM-type 3
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78491_549417463.0Zinc fingerNote=MYM-type 4
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78559_597417463.0Zinc fingerNote=MYM-type 5
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78605_652417463.0Zinc fingerNote=MYM-type 6
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78660_694417463.0Zinc fingerNote=MYM-type 7
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78701_740417463.0Zinc fingerNote=MYM-type 8
HgeneZMYM2chr13:20580726chr13:28010030ENST00000382881+78747_781417463.0Zinc fingerNote=MYM-type 9


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Fusion Gene Sequence for ZMYM2-MTIF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101347_101347_1_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382869_MTIF3_chr13_28010030_ENST00000431572_length(transcript)=2018nt_BP=1763nt
AGCGCGCGGAGGGCGGGGCCTCCCCGGGCTCGGCCGCGCCGCCGCCTCCTCCGCCTCCTCCTCCTCACCAGCGCTAAAGCCGGGACTGGA
CCGAGCGGAGTTGTGCGTGTCGCCGAAGGGGGGTGGGCCGGGGGAGGGGAGGTTCGTTCCGCGGAGCCCCAGCCAGAACCGGGACCAAGA
ATCGCCTTCAGCCCTGTCTGGTGCATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTCTTTGGCATGGACACAAGTTCAGTGG
GAGGATTAGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAGTCTCACGAATGTAGGAAACTCATTTAGTG
GTCCAGCTAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGATGATGATGTTGTTTTTATCGAACCTGTAC
AACCTCCCCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATCAAAAAATGAAGAACTACAAGGAAATGATT
CCAAAATTACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAATTGTCATTGATGATGAAGAGGACATGGAAA
CAAATCAAGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAAAAACAGAACCAATGATGTGGATTTCTCCA
CTTCCAGTTTTTCAAGAAGTAAGGTAAATGCAGGAATGGGTAATAGTGGTATCACCACAGAACCAGACTCTGAAATTCAGATTGCTAATG
TTACAACTTTAGAAACAGGTGTAAGCTCTGTGAATGATGGCCAATTAGAAAATACTGACGGGCGAGATATGAACTTAATGATTACACATG
TAACATCACTGCAGAATACCAACTTGGGAGATGTCTCTAACGGACTGCAGTCAAGTAATTTTGGTGTTAATATACAAACATACACCCCAT
CTTTAACTTCACAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGCAGGAGACGTTTTTCAGAATGGAGAATCTG
CAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAAACAACCAGGGGTGGACTCTTTATCACCAG
TGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGTTAAAGTCACTTGTGCAAACTGCAAAAAAC
CTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTACCACCTGCCTTTCTTCCTTCTCCCACAAGC
CTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCATTGTTGCTCAAGTGGATTCAAGTGAGTCCT
TCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAAAGGAGCTCTAAATAAATCAAGATGTACAA
TCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCTGTGCAGTGACCACTGCTTTAATAGATATA
GAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAAAGGTGCTGGAAATAATGTTCTGGTGATTG
ATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGATATTTCATCAAATACTCCAGACTATGCCTG
GAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGTTCTTCGTGCTTTCAGCAAAAATGAGGAGA
AGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAATGATAAGGAATCAAATGTTCTGCATCAGT

>101347_101347_1_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382869_MTIF3_chr13_28010030_ENST00000431572_length(amino acids)=594AA_BP=522
MVHPWQKVRRKTPPLFFGMDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPS
VPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSR
SKVNAGMGNSGITTEPDSEIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQT
KTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQ
TAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLT
EIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIATFS

--------------------------------------------------------------
>101347_101347_2_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382871_MTIF3_chr13_28010030_ENST00000431572_length(transcript)=1952nt_BP=1697nt
CGAAGGGGGGTGGGCCGGGGGAGGGGAGGTTCGTTCCGCGGAGCCCCAGCCAGAACCGGGACCAAGAATCGCCTTCAGCCCTGTCTGGTG
CATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTAGATGAGGTCTTAATCATGGAACATTTGAAGTCACGTAAAGAAGGTTCT
TTGGCATGGACACAAGTTCAGTGGGAGGATTAGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAGTCTCA
CGAATGTAGGAAACTCATTTAGTGGTCCAGCTAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGATGATG
ATGTTGTTTTTATCGAACCTGTACAACCTCCCCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATCAAAAA
ATGAAGAACTACAAGGAAATGATTCCAAAATTACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAATTGTCA
TTGATGATGAAGAGGACATGGAAACAAATCAAGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAAAAACA
GAACCAATGATGTGGATTTCTCCACTTCCAGTTTTTCAAGAAGTAAGGTAAATGCAGGAATGGGTAATAGTGGTATCACCACAGAACCAG
ACTCTGAAATTCAGATTGCTAATGTTACAACTTTAGAAACAGGTGTAAGCTCTGTGAATGATGGCCAATTAGAAAATACTGACGGGCGAG
ATATGAACTTAATGATTACACATGTAACATCACTGCAGAATACCAACTTGGGAGATGTCTCTAACGGACTGCAGTCAAGTAATTTTGGTG
TTAATATACAAACATACACCCCATCTTTAACTTCACAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGCAGGAG
ACGTTTTTCAGAATGGAGAATCTGCAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAAACAAC
CAGGGGTGGACTCTTTATCACCAGTGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGTTAAAG
TCACTTGTGCAAACTGCAAAAAACCTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTACCACCT
GCCTTTCTTCCTTCTCCCACAAGCCTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCATTGTTG
CTCAAGTGGATTCAAGTGAGTCCTTCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAAAGGAG
CTCTAAATAAATCAAGATGTACAATCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCTGTGCA
GTGACCACTGCTTTAATAGATATAGAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAAAGGTG
CTGGAAATAATGTTCTGGTGATTGATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGATATTTC
ATCAAATACTCCAGACTATGCCTGGAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGTTCTTC
GTGCTTTCAGCAAAAATGAGGAGAAGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAATGATA

>101347_101347_2_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382871_MTIF3_chr13_28010030_ENST00000431572_length(amino acids)=576AA_BP=504
MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNE
ELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDS
EIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDV
FQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCL
SSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSD
HCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIATFSSRPQAVQGGKALMCVLRA

--------------------------------------------------------------
>101347_101347_3_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382874_MTIF3_chr13_28010030_ENST00000431572_length(transcript)=1957nt_BP=1702nt
CCGCCGCCTCCTCCGCCTCCTCCTCCTCACCAGCGCTAAAGCCGGGACTGGACCGAGCGGAGTTGACCAAGAATCGCCTTCAGCCCTGTC
TGGTGCATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTAGATGAGGTCTTAATCATGGAACATTTGAAGTCACGTAAAGAAG
GTTCTTTGGCATGGACACAAGTTCAGTGGGAGGATTAGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAG
TCTCACGAATGTAGGAAACTCATTTAGTGGTCCAGCTAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGA
TGATGATGTTGTTTTTATCGAACCTGTACAACCTCCCCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATC
AAAAAATGAAGAACTACAAGGAAATGATTCCAAAATTACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAAT
TGTCATTGATGATGAAGAGGACATGGAAACAAATCAAGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAA
AAACAGAACCAATGATGTGGATTTCTCCACTTCCAGTTTTTCAAGAAGTAAGGTAAATGCAGGAATGGGTAATAGTGGTATCACCACAGA
ACCAGACTCTGAAATTCAGATTGCTAATGTTACAACTTTAGAAACAGGTGTAAGCTCTGTGAATGATGGCCAATTAGAAAATACTGACGG
GCGAGATATGAACTTAATGATTACACATGTAACATCACTGCAGAATACCAACTTGGGAGATGTCTCTAACGGACTGCAGTCAAGTAATTT
TGGTGTTAATATACAAACATACACCCCATCTTTAACTTCACAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGC
AGGAGACGTTTTTCAGAATGGAGAATCTGCAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAA
ACAACCAGGGGTGGACTCTTTATCACCAGTGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGT
TAAAGTCACTTGTGCAAACTGCAAAAAACCTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTAC
CACCTGCCTTTCTTCCTTCTCCCACAAGCCTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCAT
TGTTGCTCAAGTGGATTCAAGTGAGTCCTTCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAA
AGGAGCTCTAAATAAATCAAGATGTACAATCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCT
GTGCAGTGACCACTGCTTTAATAGATATAGAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAA
AGGTGCTGGAAATAATGTTCTGGTGATTGATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGAT
ATTTCATCAAATACTCCAGACTATGCCTGGAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGT
TCTTCGTGCTTTCAGCAAAAATGAGGAGAAGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAA

>101347_101347_3_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382874_MTIF3_chr13_28010030_ENST00000431572_length(amino acids)=576AA_BP=504
MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNE
ELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDS
EIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDV
FQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCL
SSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSD
HCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIATFSSRPQAVQGGKALMCVLRA

--------------------------------------------------------------
>101347_101347_4_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382881_MTIF3_chr13_28010030_ENST00000431572_length(transcript)=1750nt_BP=1495nt
GGAGGGCGGGGCCTCCCCGGGCTCGGCCGCGCCGCCGCCTCCTCCGCCTCCTCCTCCTCACCAGCGCTAAAGCCGGGACTGGACCGAGCG
GAGTTGTGCGTGTCGCCGAAGGGGGGTGGGCCGGGGGAGGGGAGGTTCGTTCCGCGGAGCCCCAGCCAGAACCGGGACCAAGAATCGCCT
TCAGCCCTGTCTGGTGCATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTCTTTGGCATGGACACAAGTTCAGTGGGAGGATT
AGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAGTCTCACGAATGTAGGAAACTCATTTAGTGGTCCAGC
TAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGATGATGATGTTGTTTTTATCGAACCTGTACAACCTCC
CCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATCAAAAAATGAAGAACTACAAGGAAATGATTCCAAAAT
TACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAATTGTCATTGATGATGAAGAGGACATGGAAACAAATCA
AGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAAAAACAGAACCAATGATGTGGATTTCTCCACTTCCAG
TTTTTCAAGAAGTAAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGCAGGAGACGTTTTTCAGAATGGAGAATC
TGCAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAAACAACCAGGGGTGGACTCTTTATCACC
AGTGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGTTAAAGTCACTTGTGCAAACTGCAAAAA
ACCTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTACCACCTGCCTTTCTTCCTTCTCCCACAA
GCCTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCATTGTTGCTCAAGTGGATTCAAGTGAGTC
CTTCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAAAGGAGCTCTAAATAAATCAAGATGTAC
AATCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCTGTGCAGTGACCACTGCTTTAATAGATA
TAGAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAAAGGTGCTGGAAATAATGTTCTGGTGAT
TGATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGATATTTCATCAAATACTCCAGACTATGCC
TGGAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGTTCTTCGTGCTTTCAGCAAAAATGAGGA
GAAGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAATGATAAGGAATCAAATGTTCTGCATCA

>101347_101347_4_ZMYM2-MTIF3_ZMYM2_chr13_20580726_ENST00000382881_MTIF3_chr13_28010030_ENST00000431572_length(amino acids)=507AA_BP=435
MVHPWQKVRRKTPPLFFGMDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPS
VPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSR
SKTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQ
KGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICG
KLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZMYM2-MTIF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZMYM2-MTIF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZMYM2-MTIF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource