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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZMYM4-AP2S1 (FusionGDB2 ID:101357)

Fusion Gene Summary for ZMYM4-AP2S1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYM4-AP2S1
Fusion gene ID: 101357
HgeneTgene
Gene symbol

ZMYM4

AP2S1

Gene ID

9202

1175

Gene namezinc finger MYM-type containing 4adaptor related protein complex 2 subunit sigma 1
SynonymsCDIR|MYM|ZNF198L3|ZNF262AP17|CLAPS2|FBH3|FBHOk|HHC3
Cytomap

1p34.3

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 4cell death inhibiting RNAzinc finger protein 262zinc finger, MYM-type 4AP-2 complex subunit sigmaHA2 17 kDa subunitadaptor protein complex AP-2 subunit sigmaadaptor related protein complex 2 sigma 1 subunitclathrin assembly protein 2 sigma small chainclathrin coat assembly protein AP17clathrin coat-associated protein A
Modification date2020031320200327
UniProtAcc.

P53680

Ensembl transtripts involved in fusion geneENST00000314607, ENST00000373297, 
ENST00000482131, 		ENST00000263270, 
ENST00000593442, ENST00000597020, 
ENST00000601649, ENST00000352203, 
ENST00000599990, ENST00000601498, 
Fusion gene scores* DoF score14 X 8 X 10=11204 X 3 X 3=36
# samples 155
** MAII scorelog2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZMYM4 [Title/Abstract] AND AP2S1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYM4(35865177)-AP2S1(47349399), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZMYM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AP2S1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1103-01AZMYM4chr1

35865177

+AP2S1chr19

47349399

-


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Fusion Gene ORF analysis for ZMYM4-AP2S1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314607ENST00000263270ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
5CDS-intronENST00000314607ENST00000593442ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
5CDS-intronENST00000314607ENST00000597020ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
5CDS-intronENST00000314607ENST00000601649ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
5CDS-intronENST00000373297ENST00000263270ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
5CDS-intronENST00000373297ENST00000593442ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
5CDS-intronENST00000373297ENST00000597020ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
5CDS-intronENST00000373297ENST00000601649ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
In-frameENST00000314607ENST00000352203ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
In-frameENST00000314607ENST00000599990ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
In-frameENST00000314607ENST00000601498ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
In-frameENST00000373297ENST00000352203ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
In-frameENST00000373297ENST00000599990ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
In-frameENST00000373297ENST00000601498ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
intron-3CDSENST00000482131ENST00000352203ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
intron-3CDSENST00000482131ENST00000599990ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
intron-3CDSENST00000482131ENST00000601498ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
intron-intronENST00000482131ENST00000263270ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
intron-intronENST00000482131ENST00000593442ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
intron-intronENST00000482131ENST00000597020ZMYM4chr1

35865177

+AP2S1chr19

47349399

-
intron-intronENST00000482131ENST00000601649ZMYM4chr1

35865177

+AP2S1chr19

47349399

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373297ZMYM4chr135865177+ENST00000352203AP2S1chr1947349399-412033418038081242
ENST00000373297ZMYM4chr135865177+ENST00000601498AP2S1chr1947349399-405633418037661228
ENST00000373297ZMYM4chr135865177+ENST00000599990AP2S1chr1947349399-405633418037661228
ENST00000314607ZMYM4chr135865177+ENST00000352203AP2S1chr1947349399-438736088040751331
ENST00000314607ZMYM4chr135865177+ENST00000601498AP2S1chr1947349399-432336088040331317
ENST00000314607ZMYM4chr135865177+ENST00000599990AP2S1chr1947349399-432336088040331317

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373297ENST00000352203ZMYM4chr135865177+AP2S1chr1947349399-0.0001470780.9998529
ENST00000373297ENST00000601498ZMYM4chr135865177+AP2S1chr1947349399-0.000221710.99977833
ENST00000373297ENST00000599990ZMYM4chr135865177+AP2S1chr1947349399-0.000221710.99977833
ENST00000314607ENST00000352203ZMYM4chr135865177+AP2S1chr1947349399-0.0001608360.9998392
ENST00000314607ENST00000601498ZMYM4chr135865177+AP2S1chr1947349399-0.0001677750.99983215
ENST00000314607ENST00000599990ZMYM4chr135865177+AP2S1chr1947349399-0.0001677750.99983215

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Fusion Genomic Features for ZMYM4-AP2S1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZMYM4-AP2S1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:35865177/chr19:47349399)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AP2S1

P53680

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23222959}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330362_40211761549.0Zinc fingerNote=MYM-type 1
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330414_45711761549.0Zinc fingerNote=MYM-type 2
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330464_49911761549.0Zinc fingerNote=MYM-type 3
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330510_54411761549.0Zinc fingerNote=MYM-type 4
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330554_59211761549.0Zinc fingerNote=MYM-type 5
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330600_63111761549.0Zinc fingerNote=MYM-type 6
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330708_74211761549.0Zinc fingerNote=MYM-type 7
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330749_78811761549.0Zinc fingerNote=MYM-type 8
HgeneZMYM4chr1:35865177chr19:47349399ENST00000314607+2330795_82911761549.0Zinc fingerNote=MYM-type 9
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128362_40210871460.0Zinc fingerNote=MYM-type 1
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128414_45710871460.0Zinc fingerNote=MYM-type 2
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128464_49910871460.0Zinc fingerNote=MYM-type 3
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128510_54410871460.0Zinc fingerNote=MYM-type 4
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128554_59210871460.0Zinc fingerNote=MYM-type 5
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128600_63110871460.0Zinc fingerNote=MYM-type 6
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128708_74210871460.0Zinc fingerNote=MYM-type 7
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128749_78810871460.0Zinc fingerNote=MYM-type 8
HgeneZMYM4chr1:35865177chr19:47349399ENST00000373297+2128795_82910871460.0Zinc fingerNote=MYM-type 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZMYM4-AP2S1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101357_101357_1_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000314607_AP2S1_chr19_47349399_ENST00000352203_length(transcript)=4387nt_BP=3608nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGTGGTGGTATCATGG
ATACAGAAATGTCTGAAGATATAGACCACAACTTAACTCCTACCCTTGACAGCATGTCTTATGGAATGCCGAATCAAACAGGATCTGAAA
ATTCATTGCTGGATGAAGATGATTATTTTTTGAACTCTGGGGATCTTGCAGGAATTCCAGTCGTTGGTAGTGACAATGAGGATGAACAGG
ATTTTAGTTCAAAGGACAATCTTGTTTCTTCAATTCATACTGATGATAGCTTGGAAGTAGAGAGAAGAGTCACACAGCATGAATCAGACA
ATGAAAATGAAATACAAATTCAAAATAAGTTAAAAAAAGACTTTCCTAAACAATTTGATCAGGTTTCTGTCTTTAAATCAATACGGAAAG
ATTTTAGTCTAGTAAGAGAAAACAGCAAAGAGACATTTTCTGGAAAGGAGAAAAATAGAGACCTAACTTATGAACGTGAAAAACGGTTGG
ATAAACCCCATAAAGATTTGGATTCAAGGTTGAAAAGCAGTTTTTTTGATAAAGCAGCTAATCAAGTTGAAGAAACATTACATACCCATT
TACCACAAACCCCAGAAACAAACTTTAGGGATTCCAGCTACCCATTTGCCAATAAAGAATCCATTGGTTCGGAACTGGGGAATTCCTTTG
CATCAAATATTAGAATTAAAGAAGAACCTTTGGATGATGAGTATGACAAAGCAATGGCACCACAGCAGGGACTACTAGACAAAATAAAAG
ATGAACCTGACAATGCTCAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCA
GTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAG
CCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTAT
TCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAA
AAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAA
CATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTC
GACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGA
ACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTA
GTTCATCGTGTATCACGGCATACAAGCAGAAATCAGCCAAAATTACACCGTGTGCGCTTTGCAAATCATTGAGATCCTCAGCAGAAATGA
TTGAAAATACCAATAGCTTGGGGAAGACAGAGCTTTTCTGTTCTGTTAATTGCTTATCTGCTTACAGAGTTAAAATGGTTACTTCTGCAG
GTGTACAAGTTCAGTGTAACAGTTGTAAAACCTCAGCAATTCCTCAGTATCACCTAGCCATGTCAGATGGAAGTATACGCAACTTCTGCA
GCTACAGCTGTGTGGTAGCTTTCCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAA
TTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAG
CTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTT
TTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATA
ATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTG
AAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCA
AATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGG
CCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTA
TCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAGCAG
GACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGAATT
CTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGCCAC
CTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATACCC
AAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATACCTC
TTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATAGTG
AAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAATGA
TTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTGAAA
AAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATGCCT
TAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTCCAT
CAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAACCCA
GACGAAGAATCCGCTTTATCCTCATCCAGAACCGGGCAGGCAAGACGCGCCTGGCCAAGTGGTACATGCAGTTTGATGATGATGAGAAAC
AGAAGCTGATCGAGGAGGTGCATGCCGTGGTCACCGTCCGAGACGCCAAACACACCAACTTTGTGGAGGTCCTGGCAATCTCCGTTGCTG
ACAGCCTCTCTGTTCTGCAGTTCCGGAACTTTAAGATCATTTACCGCCGCTATGCTGGCCTCTACTTCTGCATCTGTGTGGATGTCAATG
ACAACAACCTGGCTTACCTGGAGGCCATTCACAACTTCGTGGAGGTCTTAAACGAATATTTCCACAATGTCTGTGAACTGGACCTGGTGT
TCAACTTCTACAAGGTTTACACGGTCGTGGACGAGATGTTCCTGGCTGGCGAAATCCGAGAGACCAGCCAGACGAAGGTGCTGAAACAGC
TGCTGATGCTACAGTCCCTGGAGTGAGGGCAGGCGAGCCCCACCCCGGCCCCGGCCCCTCCTGGACTCGCCTGCTCGCTTCCCCTTCCCA
GGCCCGTGGCCAACCCAGCAGTCCTTCCCTCAGCTGCCTAGGAGGAAGGGACCCAGCTGGGTCTGGGCCACAAGGGAGGAGACTGCACCC
CACTGCCTCTGGGCCCTGGCTGTGGGCAGAGGCCACCGTGTGTGTCCCGAGTAACCGTGCCGTTGTCGTGTGATGCCATAAGCGTCTGTG

>101357_101357_1_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000314607_AP2S1_chr19_47349399_ENST00000352203_length(amino acids)=1331AA_BP=1171
MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNE
DEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYERE
KRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLD
KIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGS
TQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKN
AVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLRSS
AEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQ
GQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYK
KINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLF
YQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQP
TVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFV
PIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTK
IFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGF
PQPRRRIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEVLAISVADSLSVLQFRNFKIIYRRYAGLYFCICV

--------------------------------------------------------------
>101357_101357_2_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000314607_AP2S1_chr19_47349399_ENST00000599990_length(transcript)=4323nt_BP=3608nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGTGGTGGTATCATGG
ATACAGAAATGTCTGAAGATATAGACCACAACTTAACTCCTACCCTTGACAGCATGTCTTATGGAATGCCGAATCAAACAGGATCTGAAA
ATTCATTGCTGGATGAAGATGATTATTTTTTGAACTCTGGGGATCTTGCAGGAATTCCAGTCGTTGGTAGTGACAATGAGGATGAACAGG
ATTTTAGTTCAAAGGACAATCTTGTTTCTTCAATTCATACTGATGATAGCTTGGAAGTAGAGAGAAGAGTCACACAGCATGAATCAGACA
ATGAAAATGAAATACAAATTCAAAATAAGTTAAAAAAAGACTTTCCTAAACAATTTGATCAGGTTTCTGTCTTTAAATCAATACGGAAAG
ATTTTAGTCTAGTAAGAGAAAACAGCAAAGAGACATTTTCTGGAAAGGAGAAAAATAGAGACCTAACTTATGAACGTGAAAAACGGTTGG
ATAAACCCCATAAAGATTTGGATTCAAGGTTGAAAAGCAGTTTTTTTGATAAAGCAGCTAATCAAGTTGAAGAAACATTACATACCCATT
TACCACAAACCCCAGAAACAAACTTTAGGGATTCCAGCTACCCATTTGCCAATAAAGAATCCATTGGTTCGGAACTGGGGAATTCCTTTG
CATCAAATATTAGAATTAAAGAAGAACCTTTGGATGATGAGTATGACAAAGCAATGGCACCACAGCAGGGACTACTAGACAAAATAAAAG
ATGAACCTGACAATGCTCAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCA
GTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAG
CCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTAT
TCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAA
AAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAA
CATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTC
GACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGA
ACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTA
GTTCATCGTGTATCACGGCATACAAGCAGAAATCAGCCAAAATTACACCGTGTGCGCTTTGCAAATCATTGAGATCCTCAGCAGAAATGA
TTGAAAATACCAATAGCTTGGGGAAGACAGAGCTTTTCTGTTCTGTTAATTGCTTATCTGCTTACAGAGTTAAAATGGTTACTTCTGCAG
GTGTACAAGTTCAGTGTAACAGTTGTAAAACCTCAGCAATTCCTCAGTATCACCTAGCCATGTCAGATGGAAGTATACGCAACTTCTGCA
GCTACAGCTGTGTGGTAGCTTTCCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAA
TTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAG
CTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTT
TTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATA
ATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTG
AAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCA
AATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGG
CCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTA
TCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAGCAG
GACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGAATT
CTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGCCAC
CTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATACCC
AAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATACCTC
TTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATAGTG
AAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAATGA
TTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTGAAA
AAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATGCCT
TAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTCCAT
CAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAACCCA
GACGAAGAATCCGCTTTATCCTCATCCAGAACCGGGCAGGCAAGACGCGCCTGGCCAAGTGGTACATGCAGTTTGATGATGATGAGAAAC
AGAAGCTGATCGAGGAGGTGCATGCCGTGGTCACCGTCCGAGACGCCAAACACACCAACTTTGTGGAGTTCCGGAACTTTAAGATCATTT
ACCGCCGCTATGCTGGCCTCTACTTCTGCATCTGTGTGGATGTCAATGACAACAACCTGGCTTACCTGGAGGCCATTCACAACTTCGTGG
AGGTCTTAAACGAATATTTCCACAATGTCTGTGAACTGGACCTGGTGTTCAACTTCTACAAGGTTTACACGGTCGTGGACGAGATGTTCC
TGGCTGGCGAAATCCGAGAGACCAGCCAGACGAAGGTGCTGAAACAGCTGCTGATGCTACAGTCCCTGGAGTGAGGGCAGGCGAGCCCCA
CCCCGGCCCCGGCCCCTCCTGGACTCGCCTGCTCGCTTCCCCTTCCCAGGCCCGTGGCCAACCCAGCAGTCCTTCCCTCAGCTGCCTAGG
AGGAAGGGACCCAGCTGGGTCTGGGCCACAAGGGAGGAGACTGCACCCCACTGCCTCTGGGCCCTGGCTGTGGGCAGAGGCCACCGTGTG
TGTCCCGAGTAACCGTGCCGTTGTCGTGTGATGCCATAAGCGTCTGTGCGTGGAGTCCCCAATAAACCTGTGGTCCTGCCTGGCCTTGCC

>101357_101357_2_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000314607_AP2S1_chr19_47349399_ENST00000599990_length(amino acids)=1317AA_BP=1171
MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNE
DEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYERE
KRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLD
KIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGS
TQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKN
AVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLRSS
AEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQ
GQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYK
KINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLF
YQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQP
TVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFV
PIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTK
IFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGF
PQPRRRIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIH

--------------------------------------------------------------
>101357_101357_3_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000314607_AP2S1_chr19_47349399_ENST00000601498_length(transcript)=4323nt_BP=3608nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGTGGTGGTATCATGG
ATACAGAAATGTCTGAAGATATAGACCACAACTTAACTCCTACCCTTGACAGCATGTCTTATGGAATGCCGAATCAAACAGGATCTGAAA
ATTCATTGCTGGATGAAGATGATTATTTTTTGAACTCTGGGGATCTTGCAGGAATTCCAGTCGTTGGTAGTGACAATGAGGATGAACAGG
ATTTTAGTTCAAAGGACAATCTTGTTTCTTCAATTCATACTGATGATAGCTTGGAAGTAGAGAGAAGAGTCACACAGCATGAATCAGACA
ATGAAAATGAAATACAAATTCAAAATAAGTTAAAAAAAGACTTTCCTAAACAATTTGATCAGGTTTCTGTCTTTAAATCAATACGGAAAG
ATTTTAGTCTAGTAAGAGAAAACAGCAAAGAGACATTTTCTGGAAAGGAGAAAAATAGAGACCTAACTTATGAACGTGAAAAACGGTTGG
ATAAACCCCATAAAGATTTGGATTCAAGGTTGAAAAGCAGTTTTTTTGATAAAGCAGCTAATCAAGTTGAAGAAACATTACATACCCATT
TACCACAAACCCCAGAAACAAACTTTAGGGATTCCAGCTACCCATTTGCCAATAAAGAATCCATTGGTTCGGAACTGGGGAATTCCTTTG
CATCAAATATTAGAATTAAAGAAGAACCTTTGGATGATGAGTATGACAAAGCAATGGCACCACAGCAGGGACTACTAGACAAAATAAAAG
ATGAACCTGACAATGCTCAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCA
GTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAG
CCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTAT
TCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAA
AAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAA
CATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTC
GACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGA
ACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTA
GTTCATCGTGTATCACGGCATACAAGCAGAAATCAGCCAAAATTACACCGTGTGCGCTTTGCAAATCATTGAGATCCTCAGCAGAAATGA
TTGAAAATACCAATAGCTTGGGGAAGACAGAGCTTTTCTGTTCTGTTAATTGCTTATCTGCTTACAGAGTTAAAATGGTTACTTCTGCAG
GTGTACAAGTTCAGTGTAACAGTTGTAAAACCTCAGCAATTCCTCAGTATCACCTAGCCATGTCAGATGGAAGTATACGCAACTTCTGCA
GCTACAGCTGTGTGGTAGCTTTCCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAA
TTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAG
CTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTT
TTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATA
ATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTG
AAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCA
AATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGG
CCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTA
TCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAGCAG
GACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGAATT
CTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGCCAC
CTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATACCC
AAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATACCTC
TTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATAGTG
AAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAATGA
TTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTGAAA
AAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATGCCT
TAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTCCAT
CAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAACCCA
GACGAAGAATCCGCTTTATCCTCATCCAGAACCGGGCAGGCAAGACGCGCCTGGCCAAGTGGTACATGCAGTTTGATGATGATGAGAAAC
AGAAGCTGATCGAGGAGGTGCATGCCGTGGTCACCGTCCGAGACGCCAAACACACCAACTTTGTGGAGTTCCGGAACTTTAAGATCATTT
ACCGCCGCTATGCTGGCCTCTACTTCTGCATCTGTGTGGATGTCAATGACAACAACCTGGCTTACCTGGAGGCCATTCACAACTTCGTGG
AGGTCTTAAACGAATATTTCCACAATGTCTGTGAACTGGACCTGGTGTTCAACTTCTACAAGGTTTACACGGTCGTGGACGAGATGTTCC
TGGCTGGCGAAATCCGAGAGACCAGCCAGACGAAGGTGCTGAAACAGCTGCTGATGCTACAGTCCCTGGAGTGAGGGCAGGCGAGCCCCA
CCCCGGCCCCGGCCCCTCCTGGACTCGCCTGCTCGCTTCCCCTTCCCAGGCCCGTGGCCAACCCAGCAGTCCTTCCCTCAGCTGCCTAGG
AGGAAGGGACCCAGCTGGGTCTGGGCCACAAGGGAGGAGACTGCACCCCACTGCCTCTGGGCCCTGGCTGTGGGCAGAGGCCACCGTGTG
TGTCCCGAGTAACCGTGCCGTTGTCGTGTGATGCCATAAGCGTCTGTGCGTGGAGTCCCCAATAAACCTGTGGTCCTGCCTGGCCTTGCC

>101357_101357_3_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000314607_AP2S1_chr19_47349399_ENST00000601498_length(amino acids)=1317AA_BP=1171
MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNE
DEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYERE
KRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLD
KIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGS
TQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKN
AVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLRSS
AEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQ
GQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYK
KINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLF
YQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQP
TVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFV
PIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTK
IFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGF
PQPRRRIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIH

--------------------------------------------------------------
>101357_101357_4_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000373297_AP2S1_chr19_47349399_ENST00000352203_length(transcript)=4120nt_BP=3341nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGTGGTGGTATCATGG
ATACAGAAATGTCTGAAGATATAGACCACAACTTAACTCCTACCCTTGACAGCATGTCTTATGGAATGCCGAATCAAACAGGATCTGAAA
ATTCATTGCTGGATGAAGATGATTATTTTTTGAACTCTGGGGATCTTGCAGGAATTCCAGTCGTTGGTAGTGACAATGAGGATGAACAGG
ATTTTAGTTCAAAGGACAATCTTGTTTCTTCAATTCATACTGATGATAGCTTGGAAGTAGAGAGAAGAGTCACACAGCATGAATCAGACA
ATGAAAATGAAATACAAATTCAAAATAAGTTAAAAAAAGACTTTCCTAAACAATTTGATCAGGTTTCTGTCTTTAAATCAATACGGAAAG
ATTTTAGTCTAGTAAGAGAAAACAGCAAAGAGACATTTTCTGGAAAGGAGAAAAATAGAGACCTAACTTATGAACGTGAAAAACGGTTGG
ATAAACCCCATAAAGATTTGGATTCAAGGTTGAAAAGCAGTTTTTTTGATAAAGCAGCTAATCAAGTTGAAGAAACATTACATACCCATT
TACCACAAACCCCAGAAACAAACTTTAGGGATTCCAGCTACCCATTTGCCAATAAAGAATCCATTGGTTCGGAACTGGGGAATTCCTTTG
CATCAAATATTAGAATTAAAGAAGAACCTTTGGATGATGAGTATGACAAAGCAATGGCACCACAGCAGGGACTACTAGACAAAATAAAAG
ATGAACCTGACAATGCTCAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCA
GTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAG
CCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTAT
TCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAA
AAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAA
CATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTC
GACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGA
ACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTA
GTTCATCGTGTATCACGGCATACAAGCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAG
TAATTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTG
CAGCTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTC
TTTTTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAA
ATAATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTA
GTGAAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTC
CCAAATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGA
TGGCCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTT
GTATCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAG
CAGGACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGA
ATTCTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGC
CACCTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATA
CCCAAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATAC
CTCTTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATA
GTGAAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAA
TGATTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTG
AAAAAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATG
CCTTAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTC
CATCAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAAC
CCAGACGAAGAATCCGCTTTATCCTCATCCAGAACCGGGCAGGCAAGACGCGCCTGGCCAAGTGGTACATGCAGTTTGATGATGATGAGA
AACAGAAGCTGATCGAGGAGGTGCATGCCGTGGTCACCGTCCGAGACGCCAAACACACCAACTTTGTGGAGGTCCTGGCAATCTCCGTTG
CTGACAGCCTCTCTGTTCTGCAGTTCCGGAACTTTAAGATCATTTACCGCCGCTATGCTGGCCTCTACTTCTGCATCTGTGTGGATGTCA
ATGACAACAACCTGGCTTACCTGGAGGCCATTCACAACTTCGTGGAGGTCTTAAACGAATATTTCCACAATGTCTGTGAACTGGACCTGG
TGTTCAACTTCTACAAGGTTTACACGGTCGTGGACGAGATGTTCCTGGCTGGCGAAATCCGAGAGACCAGCCAGACGAAGGTGCTGAAAC
AGCTGCTGATGCTACAGTCCCTGGAGTGAGGGCAGGCGAGCCCCACCCCGGCCCCGGCCCCTCCTGGACTCGCCTGCTCGCTTCCCCTTC
CCAGGCCCGTGGCCAACCCAGCAGTCCTTCCCTCAGCTGCCTAGGAGGAAGGGACCCAGCTGGGTCTGGGCCACAAGGGAGGAGACTGCA
CCCCACTGCCTCTGGGCCCTGGCTGTGGGCAGAGGCCACCGTGTGTGTCCCGAGTAACCGTGCCGTTGTCGTGTGATGCCATAAGCGTCT

>101357_101357_4_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000373297_AP2S1_chr19_47349399_ENST00000352203_length(amino acids)=1242AA_BP=1082
MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNE
DEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYERE
KRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLD
KIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGS
TQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKN
AVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQNLFNKPTGMNSSVVPLS
QGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEY
KKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVL
FYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQ
PTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVF
VPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDT
KIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDG
FPQPRRRIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEVLAISVADSLSVLQFRNFKIIYRRYAGLYFCIC

--------------------------------------------------------------
>101357_101357_5_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000373297_AP2S1_chr19_47349399_ENST00000599990_length(transcript)=4056nt_BP=3341nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGTGGTGGTATCATGG
ATACAGAAATGTCTGAAGATATAGACCACAACTTAACTCCTACCCTTGACAGCATGTCTTATGGAATGCCGAATCAAACAGGATCTGAAA
ATTCATTGCTGGATGAAGATGATTATTTTTTGAACTCTGGGGATCTTGCAGGAATTCCAGTCGTTGGTAGTGACAATGAGGATGAACAGG
ATTTTAGTTCAAAGGACAATCTTGTTTCTTCAATTCATACTGATGATAGCTTGGAAGTAGAGAGAAGAGTCACACAGCATGAATCAGACA
ATGAAAATGAAATACAAATTCAAAATAAGTTAAAAAAAGACTTTCCTAAACAATTTGATCAGGTTTCTGTCTTTAAATCAATACGGAAAG
ATTTTAGTCTAGTAAGAGAAAACAGCAAAGAGACATTTTCTGGAAAGGAGAAAAATAGAGACCTAACTTATGAACGTGAAAAACGGTTGG
ATAAACCCCATAAAGATTTGGATTCAAGGTTGAAAAGCAGTTTTTTTGATAAAGCAGCTAATCAAGTTGAAGAAACATTACATACCCATT
TACCACAAACCCCAGAAACAAACTTTAGGGATTCCAGCTACCCATTTGCCAATAAAGAATCCATTGGTTCGGAACTGGGGAATTCCTTTG
CATCAAATATTAGAATTAAAGAAGAACCTTTGGATGATGAGTATGACAAAGCAATGGCACCACAGCAGGGACTACTAGACAAAATAAAAG
ATGAACCTGACAATGCTCAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCA
GTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAG
CCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTAT
TCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAA
AAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAA
CATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTC
GACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGA
ACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTA
GTTCATCGTGTATCACGGCATACAAGCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAG
TAATTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTG
CAGCTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTC
TTTTTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAA
ATAATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTA
GTGAAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTC
CCAAATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGA
TGGCCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTT
GTATCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAG
CAGGACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGA
ATTCTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGC
CACCTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATA
CCCAAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATAC
CTCTTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATA
GTGAAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAA
TGATTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTG
AAAAAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATG
CCTTAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTC
CATCAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAAC
CCAGACGAAGAATCCGCTTTATCCTCATCCAGAACCGGGCAGGCAAGACGCGCCTGGCCAAGTGGTACATGCAGTTTGATGATGATGAGA
AACAGAAGCTGATCGAGGAGGTGCATGCCGTGGTCACCGTCCGAGACGCCAAACACACCAACTTTGTGGAGTTCCGGAACTTTAAGATCA
TTTACCGCCGCTATGCTGGCCTCTACTTCTGCATCTGTGTGGATGTCAATGACAACAACCTGGCTTACCTGGAGGCCATTCACAACTTCG
TGGAGGTCTTAAACGAATATTTCCACAATGTCTGTGAACTGGACCTGGTGTTCAACTTCTACAAGGTTTACACGGTCGTGGACGAGATGT
TCCTGGCTGGCGAAATCCGAGAGACCAGCCAGACGAAGGTGCTGAAACAGCTGCTGATGCTACAGTCCCTGGAGTGAGGGCAGGCGAGCC
CCACCCCGGCCCCGGCCCCTCCTGGACTCGCCTGCTCGCTTCCCCTTCCCAGGCCCGTGGCCAACCCAGCAGTCCTTCCCTCAGCTGCCT
AGGAGGAAGGGACCCAGCTGGGTCTGGGCCACAAGGGAGGAGACTGCACCCCACTGCCTCTGGGCCCTGGCTGTGGGCAGAGGCCACCGT
GTGTGTCCCGAGTAACCGTGCCGTTGTCGTGTGATGCCATAAGCGTCTGTGCGTGGAGTCCCCAATAAACCTGTGGTCCTGCCTGGCCTT

>101357_101357_5_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000373297_AP2S1_chr19_47349399_ENST00000599990_length(amino acids)=1228AA_BP=1082
MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNE
DEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYERE
KRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLD
KIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGS
TQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKN
AVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQNLFNKPTGMNSSVVPLS
QGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEY
KKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVL
FYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQ
PTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVF
VPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDT
KIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDG
FPQPRRRIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAI

--------------------------------------------------------------
>101357_101357_6_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000373297_AP2S1_chr19_47349399_ENST00000601498_length(transcript)=4056nt_BP=3341nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGTGGTGGTATCATGG
ATACAGAAATGTCTGAAGATATAGACCACAACTTAACTCCTACCCTTGACAGCATGTCTTATGGAATGCCGAATCAAACAGGATCTGAAA
ATTCATTGCTGGATGAAGATGATTATTTTTTGAACTCTGGGGATCTTGCAGGAATTCCAGTCGTTGGTAGTGACAATGAGGATGAACAGG
ATTTTAGTTCAAAGGACAATCTTGTTTCTTCAATTCATACTGATGATAGCTTGGAAGTAGAGAGAAGAGTCACACAGCATGAATCAGACA
ATGAAAATGAAATACAAATTCAAAATAAGTTAAAAAAAGACTTTCCTAAACAATTTGATCAGGTTTCTGTCTTTAAATCAATACGGAAAG
ATTTTAGTCTAGTAAGAGAAAACAGCAAAGAGACATTTTCTGGAAAGGAGAAAAATAGAGACCTAACTTATGAACGTGAAAAACGGTTGG
ATAAACCCCATAAAGATTTGGATTCAAGGTTGAAAAGCAGTTTTTTTGATAAAGCAGCTAATCAAGTTGAAGAAACATTACATACCCATT
TACCACAAACCCCAGAAACAAACTTTAGGGATTCCAGCTACCCATTTGCCAATAAAGAATCCATTGGTTCGGAACTGGGGAATTCCTTTG
CATCAAATATTAGAATTAAAGAAGAACCTTTGGATGATGAGTATGACAAAGCAATGGCACCACAGCAGGGACTACTAGACAAAATAAAAG
ATGAACCTGACAATGCTCAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCA
GTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAG
CCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTAT
TCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAA
AAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAA
CATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTC
GACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGA
ACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTA
GTTCATCGTGTATCACGGCATACAAGCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAG
TAATTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTG
CAGCTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTC
TTTTTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAA
ATAATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTA
GTGAAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTC
CCAAATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGA
TGGCCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTT
GTATCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAG
CAGGACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGA
ATTCTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGC
CACCTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATA
CCCAAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATAC
CTCTTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATA
GTGAAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAA
TGATTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTG
AAAAAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATG
CCTTAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTC
CATCAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAAC
CCAGACGAAGAATCCGCTTTATCCTCATCCAGAACCGGGCAGGCAAGACGCGCCTGGCCAAGTGGTACATGCAGTTTGATGATGATGAGA
AACAGAAGCTGATCGAGGAGGTGCATGCCGTGGTCACCGTCCGAGACGCCAAACACACCAACTTTGTGGAGTTCCGGAACTTTAAGATCA
TTTACCGCCGCTATGCTGGCCTCTACTTCTGCATCTGTGTGGATGTCAATGACAACAACCTGGCTTACCTGGAGGCCATTCACAACTTCG
TGGAGGTCTTAAACGAATATTTCCACAATGTCTGTGAACTGGACCTGGTGTTCAACTTCTACAAGGTTTACACGGTCGTGGACGAGATGT
TCCTGGCTGGCGAAATCCGAGAGACCAGCCAGACGAAGGTGCTGAAACAGCTGCTGATGCTACAGTCCCTGGAGTGAGGGCAGGCGAGCC
CCACCCCGGCCCCGGCCCCTCCTGGACTCGCCTGCTCGCTTCCCCTTCCCAGGCCCGTGGCCAACCCAGCAGTCCTTCCCTCAGCTGCCT
AGGAGGAAGGGACCCAGCTGGGTCTGGGCCACAAGGGAGGAGACTGCACCCCACTGCCTCTGGGCCCTGGCTGTGGGCAGAGGCCACCGT
GTGTGTCCCGAGTAACCGTGCCGTTGTCGTGTGATGCCATAAGCGTCTGTGCGTGGAGTCCCCAATAAACCTGTGGTCCTGCCTGGCCTT

>101357_101357_6_ZMYM4-AP2S1_ZMYM4_chr1_35865177_ENST00000373297_AP2S1_chr19_47349399_ENST00000601498_length(amino acids)=1228AA_BP=1082
MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNE
DEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYERE
KRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLD
KIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGS
TQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKN
AVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQNLFNKPTGMNSSVVPLS
QGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEY
KKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVL
FYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQ
PTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVF
VPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDT
KIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDG
FPQPRRRIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZMYM4-AP2S1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZMYM4-AP2S1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZMYM4-AP2S1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource