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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZMYM6-TCF25 (FusionGDB2 ID:101384)

Fusion Gene Summary for ZMYM6-TCF25

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYM6-TCF25
Fusion gene ID: 101384
HgeneTgene
Gene symbol

ZMYM6

TCF25

Gene ID

9204

22980

Gene namezinc finger MYM-type containing 6transcription factor 25
SynonymsBuster2|MYM|ZBED7|ZNF198L4|ZNF258FKSG26|Hulp1|NULP1|PRO2620|hKIAA1049
Cytomap

1p34.3

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 6transposon-derived Buster2 transposase-like proteinzinc finger protein 258zinc finger, BED-type containing 7zinc finger, MYM-type 6transcription factor 25TCF-25nuclear localized protein 1transcription factor 25 (basic helix-loop-helix)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357182, ENST00000373340, 
ENST00000487874, ENST00000493328, 
ENST00000317538, ENST00000373333, 
ENST00000563406, ENST00000263347, 
ENST00000263346, 
Fusion gene scores* DoF score5 X 4 X 3=6015 X 14 X 9=1890
# samples 519
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1890*10)=-3.31431491077749
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZMYM6 [Title/Abstract] AND TCF25 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYM6(35480297)-TCF25(89949758), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTCF25

GO:0000122

negative regulation of transcription by RNA polymerase II

16574069


check buttonFusion gene breakpoints across ZMYM6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TCF25 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-AA6IZMYM6chr1

35480297

-TCF25chr16

89949758

+


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Fusion Gene ORF analysis for ZMYM6-TCF25

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000357182ENST00000563406ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5CDS-3UTRENST00000373340ENST00000563406ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5CDS-3UTRENST00000487874ENST00000563406ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5CDS-intronENST00000357182ENST00000263347ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5CDS-intronENST00000373340ENST00000263347ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5CDS-intronENST00000487874ENST00000263347ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5UTR-3CDSENST00000493328ENST00000263346ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5UTR-3UTRENST00000493328ENST00000563406ZMYM6chr1

35480297

-TCF25chr16

89949758

+
5UTR-intronENST00000493328ENST00000263347ZMYM6chr1

35480297

-TCF25chr16

89949758

+
Frame-shiftENST00000487874ENST00000263346ZMYM6chr1

35480297

-TCF25chr16

89949758

+
In-frameENST00000357182ENST00000263346ZMYM6chr1

35480297

-TCF25chr16

89949758

+
In-frameENST00000373340ENST00000263346ZMYM6chr1

35480297

-TCF25chr16

89949758

+
intron-3CDSENST00000317538ENST00000263346ZMYM6chr1

35480297

-TCF25chr16

89949758

+
intron-3CDSENST00000373333ENST00000263346ZMYM6chr1

35480297

-TCF25chr16

89949758

+
intron-3UTRENST00000317538ENST00000563406ZMYM6chr1

35480297

-TCF25chr16

89949758

+
intron-3UTRENST00000373333ENST00000563406ZMYM6chr1

35480297

-TCF25chr16

89949758

+
intron-intronENST00000317538ENST00000263347ZMYM6chr1

35480297

-TCF25chr16

89949758

+
intron-intronENST00000373333ENST00000263347ZMYM6chr1

35480297

-TCF25chr16

89949758

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373340ZMYM6chr135480297-ENST00000263346TCF25chr1689949758+300810232282861877
ENST00000357182ZMYM6chr135480297-ENST00000263346TCF25chr1689949758+300810232282861877

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373340ENST00000263346ZMYM6chr135480297-TCF25chr1689949758+0.0044955920.99550444
ENST00000357182ENST00000263346ZMYM6chr135480297-TCF25chr1689949758+0.0044955920.99550444

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Fusion Genomic Features for ZMYM6-TCF25


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZMYM6chr135480297-TCF25chr1689949758+0.1100525260.88994753
ZMYM6chr135480297-TCF25chr1689949758+0.1100525260.88994753

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZMYM6-TCF25


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:35480297/chr16:89949758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616113_1512651326.0Zinc fingerNote=MYM-type 1
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616163_2062651326.0Zinc fingerNote=MYM-type 2
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616213_2482651326.0Zinc fingerNote=MYM-type 3
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616113_151265724.0Zinc fingerNote=MYM-type 1
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616163_206265724.0Zinc fingerNote=MYM-type 2
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616213_248265724.0Zinc fingerNote=MYM-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14113_1510171.0Zinc fingerNote=MYM-type 1
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14163_2060171.0Zinc fingerNote=MYM-type 2
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14213_2480171.0Zinc fingerNote=MYM-type 3
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14296_3340171.0Zinc fingerNote=MYM-type 4
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14342_4430171.0Zinc fingerNote=MYM-type 5
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14451_4850171.0Zinc fingerNote=MYM-type 6
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14492_5310171.0Zinc fingerNote=MYM-type 7
HgeneZMYM6chr1:35480297chr16:89949758ENST00000317538-14538_5720171.0Zinc fingerNote=MYM-type 8
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616296_3342651326.0Zinc fingerNote=MYM-type 4
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616342_4432651326.0Zinc fingerNote=MYM-type 5
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616451_4852651326.0Zinc fingerNote=MYM-type 6
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616492_5312651326.0Zinc fingerNote=MYM-type 7
HgeneZMYM6chr1:35480297chr16:89949758ENST00000357182-616538_5722651326.0Zinc fingerNote=MYM-type 8
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15113_1510171.0Zinc fingerNote=MYM-type 1
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15163_2060171.0Zinc fingerNote=MYM-type 2
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15213_2480171.0Zinc fingerNote=MYM-type 3
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15296_3340171.0Zinc fingerNote=MYM-type 4
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15342_4430171.0Zinc fingerNote=MYM-type 5
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15451_4850171.0Zinc fingerNote=MYM-type 6
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15492_5310171.0Zinc fingerNote=MYM-type 7
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373333-15538_5720171.0Zinc fingerNote=MYM-type 8
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616296_334265724.0Zinc fingerNote=MYM-type 4
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616342_443265724.0Zinc fingerNote=MYM-type 5
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616451_485265724.0Zinc fingerNote=MYM-type 6
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616492_531265724.0Zinc fingerNote=MYM-type 7
HgeneZMYM6chr1:35480297chr16:89949758ENST00000373340-616538_572265724.0Zinc fingerNote=MYM-type 8


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Fusion Gene Sequence for ZMYM6-TCF25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101384_101384_1_ZMYM6-TCF25_ZMYM6_chr1_35480297_ENST00000357182_TCF25_chr16_89949758_ENST00000263346_length(transcript)=3008nt_BP=1023nt
GAGGGCGGAGACCAAGGCTGCGCAGGCGTGGTTGGCCGGTCGTTGCGTTGGGATGGATCAGGCGGAATTCCAGAAGAGAAAATAATCCCT
GTCTAGATGCAGAGGACTTGGTTCCTATTCCAGTGCTCCTCCGGTAGCAGGGAGGCGACAGAAGGTGTCCAACTATCCATTACCAAGAAG
AAATCTATTCGTTTGAGCCTGAGACACTCTTTGAGGTAAAAAATTAGAATGAAAGAACCTTTGGATGGTGAATGTGGCAAAGCAGTGGTA
CCACAGCAGGAGCTTCTGGACAAAATTAAAGAAGAACCAGACAATGCTCAAGAGTATGGATGTGTCCAACAGCCAAAAACTCAAGAAAGT
AAATTGAAAATTGGTGGTGTGTCTTCAGTTAATGAGAGACCTATTGCCCAGCAGTTGAACCCAGGCTTTCAGCTTTCTTTTGCATCATCT
GGCCCAAGTGTGTTGCTTCCTTCAGTTCCAGCTGTTGCTATTAAGGTTTTTTGTTCTGGTTGTAAAAAAATGCTTTATAAGGGCCAAACT
GCATATCATAAGACAGGATCTACTCAGCTCTTCTGCTCCACACGATGCATCACCAGACATTCTTCACCTGCCTGCCTGCCACCTCCTCCC
AAGAAAACCTGCACAAACTGCTCGAAAGACATTTTAAATCCTAAGGATGTGATCACAACTCGCTTTGAGAATTCCTATCCTAGCAAAGAT
TTCTGCAGCCAATCATGCTTGTCATCTTATGAGCTAAAGAAAAAACCTGTTGTTACCATATATACCAAAAGCATTTCAACTAAGTGCAGT
ATGTGTCAGAAGAATGCTGATACTCGATTTGAAGTTAAATATCAAAATGTGGTACATGGTCTTTGTAGTGATGCCTGTTTTTCAAAATTT
CACTCTACAAACAACCTCACCATGAACTGTTGTGAGAACTGTGGGAGCTATTGCTATAGTAGCTCTGGTCCTTGCCAATCCCAGAAGGTT
TTTAGTTCAACAAGTGTCACGGCATACAAGCAGATAAACATTGACGATCTTGAGGATGACCCTGTGGTGAACGGGGAGAGGTCTGGCTGT
GCGCTCACAGACGCTGTGGCACCAGGGAACAAAGGAAGGGGTCAGCGTGGAAACACAGAGAGCAAGACGGATGGAGATGACACCGAGACA
GTGCCCTCAGAGCAGTCTCATGCAAGTGGCAAACTCCGGAAGAAGAAAAAAAAACAGAAAAACAAGAAAAGCAGCACGGGAGAAGCATCG
GAAAACGGACTAGAAGATATCGATCGCATCCTAGAGAGGATTGAGGACAGCACTGGGTTGAACCGTCCCGGCCCAGCTCCCCTGAGCTCC
AGGAAGCACGTTCTCTACGTGGAGCACAGACACTTGAATCCAGACACAGAACTGAAAAGGTATTTTGGTGCCCGGGCAATCCTGGGGGAG
CAAAGGCCACGGCAGAGACAACGTGTGTACCCCAAGTGCACATGGCTGACCACCCCTAAAAGCACCTGGCCCCGCTACAGCAAACCAGGT
CTGTCCATGCGGCTGCTGGAATCAAAAAAAGGCCTCTCCTTCTTTGCGTTTGAGCACAGTGAGGAGTACCAGCAGGCTCAGCACAAGTTC
CTGGTGGCCGTGGAGTCTATGGAGCCGAACAACATCGTGGTTCTGCTCCAGACGAGCCCTTACCACGTTGACTCACTCCTGCAGCTCAGC
GATGCCTGCCGCTTTCAAGAGGATCAGGAGATGGCTCGAGACCTCGTAGAGAGAGCGCTGTACAGCATGGAATGTGCGTTCCACCCCCTG
TTCAGTCTCACCAGTGGGGCCTGCCGGCTGGATTACCGCAGACCCGAGAACAGGAGCTTCTACCTGGCCCTCTACAAGCAGATGAGCTTC
CTGGAGAAGCGAGGCTGCCCGCGCACGGCGCTGGAGTACTGCAAGCTCATCCTGAGTCTCGAGCCGGATGAGGACCCCCTCTGCATGCTG
CTGCTCATCGACCACCTGGCCTTGCGGGCCCGGAACTACGAGTACCTGATCCGCCTCTTCCAGGAGTGGGAGGCTCATCGGAACCTGTCC
CAGCTCCCTAATTTTGCCTTCTCTGTTCCACTGGCGTATTTCCTGCTGAGCCAGCAGACAGACCTCCCTGAGTGTGAGCAGAGCTCTGCC
AGGCAGAAGGCCTCTCTCCTGATACAGCAGGCGCTCACCATGTTCCCTGGAGTCCTCCTGCCCCTGCTCGAGTCTTGCAGTGTGCGGCCC
GACGCCAGCGTTTCCAGTCACCGCTTCTTTGGACCCAATGCTGAAATAAGCCAGCCCCCTGCCCTGAGCCAGCTGGTGAACCTGTACCTT
GGGAGGTCACACTTTCTCTGGAAAGAGCCCGCCACCATGAGCTGGCTGGAGGAGAACGTCCACGAGGTTCTGCAAGCAGTGGACGCCGGG
GACCCAGCCGTGGAAGCCTGTGAGAACCGGCGGAAGGTGCTCTACCAGCGTGCACCCAGGAATATCCACCGCCATGTGATCCTCTCTGAG
ATCAAGGAAGCCGTCGCTGCCCTGCCCCCGGACGTGACCACGCAGTCTGTGATGGGGTTTGATCCTCTGCCTCCTTCGGACACAATCTAC
TCCTACGTCAGGCCAGAGAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATG
GAGGGGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATG
GCCAACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACC
GAAAAGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTGAGTGTGTCGCTCCCTGG

>101384_101384_1_ZMYM6-TCF25_ZMYM6_chr1_35480297_ENST00000357182_TCF25_chr16_89949758_ENST00000263346_length(amino acids)=877AA_BP=264
MKEPLDGECGKAVVPQQELLDKIKEEPDNAQEYGCVQQPKTQESKLKIGGVSSVNERPIAQQLNPGFQLSFASSGPSVLLPSVPAVAIKV
FCSGCKKMLYKGQTAYHKTGSTQLFCSTRCITRHSSPACLPPPPKKTCTNCSKDILNPKDVITTRFENSYPSKDFCSQSCLSSYELKKKP
VVTIYTKSISTKCSMCQKNADTRFEVKYQNVVHGLCSDACFSKFHSTNNLTMNCCENCGSYCYSSSGPCQSQKVFSSTSVTAYKQINIDD
LEDDPVVNGERSGCALTDAVAPGNKGRGQRGNTESKTDGDDTETVPSEQSHASGKLRKKKKKQKNKKSSTGEASENGLEDIDRILERIED
STGLNRPGPAPLSSRKHVLYVEHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLESKKGLSFFA
FEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPE
NRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLL
SQQTDLPECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSHRFFGPNAEISQPPALSQLVNLYLGRSHFLWKEPATMSWL
EENVHEVLQAVDAGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPERLSPISHGNT

--------------------------------------------------------------
>101384_101384_2_ZMYM6-TCF25_ZMYM6_chr1_35480297_ENST00000373340_TCF25_chr16_89949758_ENST00000263346_length(transcript)=3008nt_BP=1023nt
GAGGGCGGAGACCAAGGCTGCGCAGGCGTGGTTGGCCGGTCGTTGCGTTGGGATGGATCAGGCGGAATTCCAGAAGAGAAAATAATCCCT
GTCTAGATGCAGAGGACTTGGTTCCTATTCCAGTGCTCCTCCGGTAGCAGGGAGGCGACAGAAGGTGTCCAACTATCCATTACCAAGAAG
AAATCTATTCGTTTGAGCCTGAGACACTCTTTGAGGTAAAAAATTAGAATGAAAGAACCTTTGGATGGTGAATGTGGCAAAGCAGTGGTA
CCACAGCAGGAGCTTCTGGACAAAATTAAAGAAGAACCAGACAATGCTCAAGAGTATGGATGTGTCCAACAGCCAAAAACTCAAGAAAGT
AAATTGAAAATTGGTGGTGTGTCTTCAGTTAATGAGAGACCTATTGCCCAGCAGTTGAACCCAGGCTTTCAGCTTTCTTTTGCATCATCT
GGCCCAAGTGTGTTGCTTCCTTCAGTTCCAGCTGTTGCTATTAAGGTTTTTTGTTCTGGTTGTAAAAAAATGCTTTATAAGGGCCAAACT
GCATATCATAAGACAGGATCTACTCAGCTCTTCTGCTCCACACGATGCATCACCAGACATTCTTCACCTGCCTGCCTGCCACCTCCTCCC
AAGAAAACCTGCACAAACTGCTCGAAAGACATTTTAAATCCTAAGGATGTGATCACAACTCGCTTTGAGAATTCCTATCCTAGCAAAGAT
TTCTGCAGCCAATCATGCTTGTCATCTTATGAGCTAAAGAAAAAACCTGTTGTTACCATATATACCAAAAGCATTTCAACTAAGTGCAGT
ATGTGTCAGAAGAATGCTGATACTCGATTTGAAGTTAAATATCAAAATGTGGTACATGGTCTTTGTAGTGATGCCTGTTTTTCAAAATTT
CACTCTACAAACAACCTCACCATGAACTGTTGTGAGAACTGTGGGAGCTATTGCTATAGTAGCTCTGGTCCTTGCCAATCCCAGAAGGTT
TTTAGTTCAACAAGTGTCACGGCATACAAGCAGATAAACATTGACGATCTTGAGGATGACCCTGTGGTGAACGGGGAGAGGTCTGGCTGT
GCGCTCACAGACGCTGTGGCACCAGGGAACAAAGGAAGGGGTCAGCGTGGAAACACAGAGAGCAAGACGGATGGAGATGACACCGAGACA
GTGCCCTCAGAGCAGTCTCATGCAAGTGGCAAACTCCGGAAGAAGAAAAAAAAACAGAAAAACAAGAAAAGCAGCACGGGAGAAGCATCG
GAAAACGGACTAGAAGATATCGATCGCATCCTAGAGAGGATTGAGGACAGCACTGGGTTGAACCGTCCCGGCCCAGCTCCCCTGAGCTCC
AGGAAGCACGTTCTCTACGTGGAGCACAGACACTTGAATCCAGACACAGAACTGAAAAGGTATTTTGGTGCCCGGGCAATCCTGGGGGAG
CAAAGGCCACGGCAGAGACAACGTGTGTACCCCAAGTGCACATGGCTGACCACCCCTAAAAGCACCTGGCCCCGCTACAGCAAACCAGGT
CTGTCCATGCGGCTGCTGGAATCAAAAAAAGGCCTCTCCTTCTTTGCGTTTGAGCACAGTGAGGAGTACCAGCAGGCTCAGCACAAGTTC
CTGGTGGCCGTGGAGTCTATGGAGCCGAACAACATCGTGGTTCTGCTCCAGACGAGCCCTTACCACGTTGACTCACTCCTGCAGCTCAGC
GATGCCTGCCGCTTTCAAGAGGATCAGGAGATGGCTCGAGACCTCGTAGAGAGAGCGCTGTACAGCATGGAATGTGCGTTCCACCCCCTG
TTCAGTCTCACCAGTGGGGCCTGCCGGCTGGATTACCGCAGACCCGAGAACAGGAGCTTCTACCTGGCCCTCTACAAGCAGATGAGCTTC
CTGGAGAAGCGAGGCTGCCCGCGCACGGCGCTGGAGTACTGCAAGCTCATCCTGAGTCTCGAGCCGGATGAGGACCCCCTCTGCATGCTG
CTGCTCATCGACCACCTGGCCTTGCGGGCCCGGAACTACGAGTACCTGATCCGCCTCTTCCAGGAGTGGGAGGCTCATCGGAACCTGTCC
CAGCTCCCTAATTTTGCCTTCTCTGTTCCACTGGCGTATTTCCTGCTGAGCCAGCAGACAGACCTCCCTGAGTGTGAGCAGAGCTCTGCC
AGGCAGAAGGCCTCTCTCCTGATACAGCAGGCGCTCACCATGTTCCCTGGAGTCCTCCTGCCCCTGCTCGAGTCTTGCAGTGTGCGGCCC
GACGCCAGCGTTTCCAGTCACCGCTTCTTTGGACCCAATGCTGAAATAAGCCAGCCCCCTGCCCTGAGCCAGCTGGTGAACCTGTACCTT
GGGAGGTCACACTTTCTCTGGAAAGAGCCCGCCACCATGAGCTGGCTGGAGGAGAACGTCCACGAGGTTCTGCAAGCAGTGGACGCCGGG
GACCCAGCCGTGGAAGCCTGTGAGAACCGGCGGAAGGTGCTCTACCAGCGTGCACCCAGGAATATCCACCGCCATGTGATCCTCTCTGAG
ATCAAGGAAGCCGTCGCTGCCCTGCCCCCGGACGTGACCACGCAGTCTGTGATGGGGTTTGATCCTCTGCCTCCTTCGGACACAATCTAC
TCCTACGTCAGGCCAGAGAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATG
GAGGGGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATG
GCCAACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACC
GAAAAGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTGAGTGTGTCGCTCCCTGG

>101384_101384_2_ZMYM6-TCF25_ZMYM6_chr1_35480297_ENST00000373340_TCF25_chr16_89949758_ENST00000263346_length(amino acids)=877AA_BP=264
MKEPLDGECGKAVVPQQELLDKIKEEPDNAQEYGCVQQPKTQESKLKIGGVSSVNERPIAQQLNPGFQLSFASSGPSVLLPSVPAVAIKV
FCSGCKKMLYKGQTAYHKTGSTQLFCSTRCITRHSSPACLPPPPKKTCTNCSKDILNPKDVITTRFENSYPSKDFCSQSCLSSYELKKKP
VVTIYTKSISTKCSMCQKNADTRFEVKYQNVVHGLCSDACFSKFHSTNNLTMNCCENCGSYCYSSSGPCQSQKVFSSTSVTAYKQINIDD
LEDDPVVNGERSGCALTDAVAPGNKGRGQRGNTESKTDGDDTETVPSEQSHASGKLRKKKKKQKNKKSSTGEASENGLEDIDRILERIED
STGLNRPGPAPLSSRKHVLYVEHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLESKKGLSFFA
FEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPE
NRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLL
SQQTDLPECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSHRFFGPNAEISQPPALSQLVNLYLGRSHFLWKEPATMSWL
EENVHEVLQAVDAGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPERLSPISHGNT

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Fusion Gene PPI Analysis for ZMYM6-TCF25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZMYM6-TCF25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZMYM6-TCF25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource