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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZMYND8-RHPN2 (FusionGDB2 ID:101412)

Fusion Gene Summary for ZMYND8-RHPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYND8-RHPN2
Fusion gene ID: 101412
HgeneTgene
Gene symbol

ZMYND8

RHPN2

Gene ID

23613

85415

Gene namezinc finger MYND-type containing 8rhophilin Rho GTPase binding protein 2
SynonymsPRKCBP1|PRO2893|RACK7P76RBE|RHOBP
Cytomap

20q13.12

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8rhophilin-276 kDa RhoB effector proteinGTP-Rho-binding protein 2rhophilin-like Rho-GTPase binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262975, ENST00000311275, 
ENST00000352431, ENST00000355972, 
ENST00000360911, ENST00000372023, 
ENST00000396281, ENST00000446994, 
ENST00000458360, ENST00000461685, 
ENST00000471951, ENST00000536340, 
ENST00000540497, ENST00000468376, 
ENST00000400226, ENST00000588683, 
ENST00000254260, 
Fusion gene scores* DoF score25 X 23 X 10=57506 X 4 X 6=144
# samples 347
** MAII scorelog2(34/5750*10)=-4.0799553045814
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZMYND8 [Title/Abstract] AND RHPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYND8(45874751)-RHPN2(33535270), # samples:1
Anticipated loss of major functional domain due to fusion event.ZMYND8-RHPN2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZMYND8-RHPN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZMYND8-RHPN2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZMYND8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RHPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer131NdZMYND8chr20

45874751

-RHPN2chr19

33535270

-


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Fusion Gene ORF analysis for ZMYND8-RHPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262975ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000311275ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000352431ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000355972ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000360911ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000372023ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000396281ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000446994ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000458360ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000461685ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000471951ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000536340ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-5UTRENST00000540497ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000262975ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000311275ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000352431ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000355972ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000360911ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000372023ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000396281ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000446994ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000458360ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000461685ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000471951ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000536340ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5CDS-intronENST00000540497ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5UTR-3CDSENST00000468376ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5UTR-5UTRENST00000468376ENST00000400226ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
5UTR-intronENST00000468376ENST00000588683ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000311275ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000352431ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000360911ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000372023ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000396281ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000458360ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000461685ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000471951ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000536340ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
Frame-shiftENST00000540497ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
In-frameENST00000262975ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
In-frameENST00000355972ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-
In-frameENST00000446994ENST00000254260ZMYND8chr20

45874751

-RHPN2chr19

33535270

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262975ZMYND8chr2045874751-ENST00000254260RHPN2chr1933535270-590325082392515758
ENST00000446994ZMYND8chr2045874751-ENST00000254260RHPN2chr1933535270-55192124442131695
ENST00000355972ZMYND8chr2045874751-ENST00000254260RHPN2chr1933535270-577923841152391758

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262975ENST00000254260ZMYND8chr2045874751-RHPN2chr1933535270-0.0019143650.9980856
ENST00000446994ENST00000254260ZMYND8chr2045874751-RHPN2chr1933535270-0.0013365770.9986634
ENST00000355972ENST00000254260ZMYND8chr2045874751-RHPN2chr1933535270-0.0018449030.99815506

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Fusion Genomic Features for ZMYND8-RHPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZMYND8-RHPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:45874751/chr19:33535270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-152443_477411169.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-142243_477411187.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-142243_477611161.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-152443_477411215.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-142243_477361136.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-142343_477611189.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-142343_477611235.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-1524165_2357411169.0DomainBromo
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-1524277_3277411169.0DomainPWWP
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-1422165_2357411187.0DomainBromo
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-1422277_3277411187.0DomainPWWP
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-1422165_2357611161.0DomainBromo
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-1422277_3277611161.0DomainPWWP
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-1524165_2357411215.0DomainBromo
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-1524277_3277411215.0DomainPWWP
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-1422165_2357361136.0DomainBromo
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-1422277_3277361136.0DomainPWWP
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-1423165_2357611189.0DomainBromo
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-1423277_3277611189.0DomainPWWP
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-1423165_2357611235.0DomainBromo
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-1423277_3277611235.0DomainPWWP
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-152488_1337411169.0Zinc fingerPHD-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-142288_1337411187.0Zinc fingerPHD-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-142288_1337611161.0Zinc fingerPHD-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-152488_1337411215.0Zinc fingerPHD-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-142288_1337361136.0Zinc fingerPHD-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-142388_1337611189.0Zinc fingerPHD-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-142388_1337611235.0Zinc fingerPHD-type
TgeneRHPN2chr20:45874751chr19:33535270ENST00000254260015623_62623687.0Compositional biasNote=Poly-Asp
TgeneRHPN2chr20:45874751chr19:33535270ENST00000254260015111_46023687.0DomainBRO1
TgeneRHPN2chr20:45874751chr19:33535270ENST0000025426001526_10023687.0DomainREM-1
TgeneRHPN2chr20:45874751chr19:33535270ENST00000254260015515_59323687.0DomainNote=PDZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-15241089_10927411169.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-1524838_8547411169.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-14221089_10927411187.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-1422838_8547411187.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-14221089_10927611161.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-1422838_8547611161.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-15241089_10927411215.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-1524838_8547411215.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-14221089_10927361136.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-1422838_8547361136.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-14231089_10927611189.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-1423838_8547611189.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-14231089_10927611235.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-1423838_8547611235.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-15241028_10627411169.0Zinc fingerMYND-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-14221028_10627411187.0Zinc fingerMYND-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-14221028_10627611161.0Zinc fingerMYND-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-15241028_10627411215.0Zinc fingerMYND-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-14221028_10627361136.0Zinc fingerMYND-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-14231028_10627611189.0Zinc fingerMYND-type
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-14231028_10627611235.0Zinc fingerMYND-type


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Fusion Gene Sequence for ZMYND8-RHPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101412_101412_1_ZMYND8-RHPN2_ZMYND8_chr20_45874751_ENST00000262975_RHPN2_chr19_33535270_ENST00000254260_length(transcript)=5903nt_BP=2508nt
CGGCTTTACACTCCGATTTGCCGGGGCAGCCAATCGGGGATGAGCTTTTATTAGGCGGCCAGATCATCAGCCGAAGTGCCAAACCCTTTT
TCTGTGAGAACTAGGAGCCTGTCCTCCATGTTTTATAAGTATTGACATTACACAGTGTTAACAATGCATCCACAGAGTCCCAAATCTGCC
AGCCTGTTCTCTCTTCCTAACTGTGGAAAAATGAGACGGTTGCTTGAACATTTGTTGGCTTGGCTGAAGAGGAAATAAAAACAGAACAGG
AGGTGGTAGAGGGCATGGATATCTCTACTCGCTCCAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTC
CACATTCTTCCAATGGCCACTCGCCGCAGGACACATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATA
AGGAGCAGTCAGAACTAAGACATGGTCCGTTTTACTATATGAAGCAGCCACTCACCACAGACCCTGTTGATGTTGTACCGCAGGATGGAC
GGAATGATTTCTACTGCTGGGTTTGTCACCGGGAAGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGA
GACTGACATCGGAACCAGAGGGGGACTGGTTTTGTCCTGAATGTGAGAAAATTACAGTAGCAGAATGCATCGAGACCCAGAGTAAAGCCA
TGACAATGCTCACCATTGAACAGTTATCCTACCTGCTCAAGTTTGCCATTCAGAAAATGAAACAGCCAGGGACAGATGCATTCCAGAAGC
CCGTTCCATTGGAACAGCACCCTGACTATGCGGAATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAA
TGTATGGCTGCACAGAAGCCTTCCTGGCTGATGCAAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGC
AAATAGCGAAAGTAGTCATCAAAATCTGTGAACATGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAAC
GAGATAACTGGTTTTGTGAGCCTTGTAGCAATCCACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTC
TAAGGGATAAAGACGGGCAGGTCGATGCCCGATTCTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTA
AAGAAATTCCTTTTTCTGTGAAAAAGACTAAGAGCATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGA
AGTTTGGGGTTTTTAATTACTCTCCATTTAGGACACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCG
CCGGCACTGCCAAGATAGACAAGCAGGAGAAGGTCAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGC
TGAGTGGGGGCACAGGCCGCCGGATTTCCTTGTCGGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACG
TGGAGCAGGATGCTGAGAAGAAGGCCACGTCGAGCCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCAC
CAGCCTCCACCAAGACGGGACAAGCAGGGAGTTTATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAA
CGGACAAAACCTCCACCACCGGCAGCATCCTGAATCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGG
TCCAGCAACAGTCCACCCCTGTTCCTCTCATCTCTCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGA
GTTGCAAAGCACAATTAGGCATAAATGAAATCTCGGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAG
ATAGTAGCGATAGTGAGTATATCAGTGATGATGAGCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGG
ACAAAGAGCCATCTGCTGTTAAAAAAAAGCCCAAGCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCG
AGAAGGCAGACCCTGGAGCAGTCAAGGACAAGGCCAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCA
TAAAGGATAAACTGAAGGGAAAAGATGAGACGGATTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAG
ATTTAGGAGAAGACCATTCTGGGCGGGAGGGTCGAAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGGGCTGTAATCCC
CTTGCACAAACCGGCCGGAGTAAATTGCAGAATCAAAGAGCTGCTTTGAATCAGCAGATCCTGAAAGCCGTGCGGATGAGGACCGGAGCG
GAAAACCTTCTGAAAGTGGCCACAAACTCAAAGGTGCGGGAGCAAGTGCGGCTGGAGCTGAGCTTCGTCAACTCAGACCTGCAGATGCTC
AAGGAAGAGCTGGAGGGGCTGAACATCTCGGTGGGCGTCTATCAGAACACAGAGGAGGCATTTACGATTCCCCTGATTCCTCTTGGCCTG
AAGGAAACGAAAGACGTCGACTTTGCAGTCGTCCTCAAGGATTTTATCCTGGAACATTACAGTGAAGATGGCTATTTATATGAAGATGAA
ATTGCAGATCTTATGGATCTGAGACAAGCTTGTCGGACGCCTAGCCGGGATGAGGCCGGGGTGGAACTGCTGATGACATACTTCATCCAG
CTGGGCTTTGTCGAGAGTCGATTCTTCCCGCCCACACGGCAGATGGGACTCCTGTTCACCTGGTATGACTCTCTCACCGGGGTTCCGGTC
AGCCAGCAGAACCTGCTGCTGGAGAAGGCCAGTGTCCTGTTCAACACTGGGGCCCTCTACACCCAGATTGGGACCCGGTGTGATCGGCAG
ACGCAGGCTGGGCTGGAGAGTGCCATAGATGCCTTTCAGAGAGCCGCAGGGGTTTTAAATTACCTGAAAGACACATTTACCCATACTCCA
AGTTACGACATGAGCCCTGCCATGCTCAGCGTGCTCGTCAAAATGATGCTTGCACAAGCCCAAGAAAGCGTGTTTGAGAAAATCAGCCTT
CCTGGGATCCGGAATGAATTCTTCATGCTGGTGAAGGTGGCTCAGGAGGCTGCTAAGGTGGGAGAGGTCTACCAACAGCTACACGCAGCC
ATGAGCCAGGCGCCGGTGAAAGAGAACATCCCCTACTCCTGGGCCAGCTTAGCCTGCGTGAAGGCCCACCACTACGCGGCCCTGGCCCAC
TACTTCACTGCCATCCTCCTCATCGACCACCAGGTGAAGCCAGGCACGGATCTGGACCACCAGGAGAAGTGCCTGTCCCAGCTCTACGAC
CACATGCCAGAGGGGCTGACACCCTTGGCCACACTGAAGAATGATCAGCAGCGCCGACAGCTGGGGAAGTCCCACTTGCGCAGAGCCATG
GCTCATCACGAGGAGTCGGTGCGGGAGGCCAGCCTCTGCAAGAAGCTGCGGAGCATTGAGGTGCTACAGAAGGTGCTGTGTGCCGCACAG
GAACGCTCCCGGCTCACGTACGCCCAGCACCAGGAGGAGGATGACCTGCTGAACCTGATCGACGCCCCCAGTGTTGTTGCTAAAACTGAG
CAAGAGGTTGACATTATATTGCCCCAGTTCTCCAAGCTGACAGTCACGGACTTCTTCCAGAAGCTGGGCCCCTTATCTGTGTTTTCGGCT
AACAAGCGGTGGACGCCTCCTCGAAGCATCCGCTTCACTGCAGAAGAAGGGGACTTGGGGTTCACCTTGAGAGGGAACGCCCCCGTTCAG
GTTCACTTCCTGGATCCTTACTGCTCTGCCTCGGTGGCAGGAGCCCGGGAAGGAGATTATATTGTCTCCATTCAGCTTGTGGATTGTAAG
TGGCTGACGCTGAGTGAGGTTATGAAGCTGCTGAAGAGCTTTGGCGAGGACGAGATCGAGATGAAAGTCGTGAGCCTCCTGGACTCCACA
TCATCCATGCATAATAAGAGTGCCACATACTCCGTGGGAATGCAGAAAACGTACTCCATGATCTGCTTAGCCATTGATGATGACGACAAA
ACTGATAAAACCAAGAAAATCTCCAAGAAGCTTTCCTTCCTGAGTTGGGGCACCAACAAGAACAGACAGAAGTCAGCCAGCACCTTGTGC
CTCCCATCGGTCGGGGCTGCACGGCCTCAGGTCAAGAAGAAGCTGCCCTCCCCTTTCAGCCTTCTCAACTCAGACAGTTCTTGGTACTAA
TGTGAGGAAACAAACATGTTCAGGCCCTGAACATTTCCGGTGCTGACTCGGCCTTAAACGTTTGTGCCATAATGGAAAATATCTATCTAT
CTGTTCTCAAATCCTGTTTTTCTCATAGTGTAAACTCACATTTGATGTGTTTTTATGAAGGAAAGTAACCAAGAAACCTCTAGGAATTAG
TGAAAAAAGAACTTTTTTGAGGTGTGTTACTATACTGCTGTAAGTTATTTATTATATAAAGTATTGTAAATAGAATAGTGTTGAAGATAT
GAAATATGGCTATTTTTAATGGTGACAATTATGACTTTTAGTCACTATTAAATTGGGGTTACCTATATCAGTACAATTTGTAGTTGTTTC
CAGGTTTGGCTAATAATCATTCCTTAACCTAGAATTCAGATGATCCTGGAATTAAGGCAGGTCAGAGGACTGTAATGATAGAATTAAATT
AGTGTCACTAAAAACTGTCCCAAAGTGCTGCTTCCTAATAGGAATTCATTAACCTAAAACAAGATGTTACTATTATATCGATAGACTATG
AATGCTATTTCTAGAAAAAGTCTAGTGCCAAATTTGTCTTATTAAATAAAAACAATGTAGGAGCAGCTTTTCTTCTAGTTTGATGTCATT
TAAGAATTACTAACACAGTGGCAGTGTTAGATGAAGATGCTGTCTACAAGGTAGATAATATACTGTTTGATACTCAAAACATTTTTCATT
TTGTTTAAAGTAGAAGTTACATAATTCTATATTTTAAGTCTTGGGTAAAAAAGTAGTTTTACATTTTATAAAGTAAAGATGTAAATGATT
CAGGTTTAAAGCTCTATTTGACTTCCTTTTTTTGTTTGAGATAGCGTCTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAG
CTCAGTGCAACCTCCGCCCCCTGGGATCAAGCGATTCTCCTACCTCAGCCTCCCAAATAGCTGGGACTACAAGGTGCCCTCCAGCATGCC
TGGCTGATTTTTGTATTTTTAGTTGAGGTGAGGTTTCACCATGTTGGCCAGGCGGGTTTCGAAATCCTGACCTCAAATGATCCACCCACC
TCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACAACCGTCCCACTATTTTACTTTTTAAAATGACATTCCTACTGATTGAT
TTTTATCTTGCTATAAGTTCGATGACACCGTGAATCTAATAAGGTTCACTGTTGACACAGTACAAGTTACATAGCTAAAATACATAGCAT
TGAAGACTAATTTTAAGGATTGACAAGAGTTTATTTTCTATTGTGCAATATCTTAAAGGAAGCAACCACCTTTGGGAAAGTGTATCTGCT

>101412_101412_1_ZMYND8-RHPN2_ZMYND8_chr20_45874751_ENST00000262975_RHPN2_chr19_33535270_ENST00000254260_length(amino acids)=758AA_BP=
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT
DPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKM
KQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVC
PECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQE
MEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMS
TNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKA
EMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPE
DTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGL

--------------------------------------------------------------
>101412_101412_2_ZMYND8-RHPN2_ZMYND8_chr20_45874751_ENST00000355972_RHPN2_chr19_33535270_ENST00000254260_length(transcript)=5779nt_BP=2384nt
ATAAGTATTGACATTACACAGTGTTAACAATGCATCCACAGAGTCCCAAATCTGCCAGCCTGTTCTCTCTTCCTAACTGTGGAAAAATGA
GACGGTTGCTTGAACATTTGTTGGCTTGGCTGAAGAGGAAATAAAAACAGAACAGGAGGTGGTAGAGGGCATGGATATCTCTACTCGCTC
CAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTCCACATTCTTCCAATGGCCACTCGCCGCAGGACAC
ATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATAAGGAGCAGTCAGAACTAAGACATGGTCCGTTTTA
CTATATGAAGCAGCCACTCACCACAGACCCTGTTGATGTTGTACCGCAGGATGGACGGAATGATTTCTACTGCTGGGTTTGTCACCGGGA
AGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGAGACTGACATCGGAACCAGAGGGGGACTGGTTTTG
TCCTGAATGTGAGAAAATTACAGTAGCAGAATGCATCGAGACCCAGAGTAAAGCCATGACAATGCTCACCATTGAACAGTTATCCTACCT
GCTCAAGTTTGCCATTCAGAAAATGAAACAGCCAGGGACAGATGCATTCCAGAAGCCCGTTCCATTGGAACAGCACCCTGACTATGCGGA
ATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAATGTATGGCTGCACAGAAGCCTTCCTGGCTGATGC
AAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGCAAATAGCGAAAGTAGTCATCAAAATCTGTGAACA
TGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAACGAGATAACTGGTTTTGTGAGCCTTGTAGCAATCC
ACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTCTAAGGGATAAAGACGGGCAGGTCGATGCCCGATT
CTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTAAAGAAATTCCTTTTTCTGTGAAAAAGACTAAGAG
CATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGAAGTTTGGGGTTTTTAATTACTCTCCATTTAGGAC
ACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCGCCGGCACTGCCAAGATAGACAAGCAGGAGAAGGT
CAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGCTGAGTGGGGGCACAGGCCGCCGGATTTCCTTGTC
GGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACGTGGAGCAGGATGCTGAGAAGAAGGCCACGTCGAG
CCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCACCAGCCTCCACCAAGACGGGACAAGCAGGGAGTTT
ATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAACGGACAAAACCTCCACCACCGGCAGCATCCTGAA
TCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGGTCCAGCAACAGTCCACCCCTGTTCCTCTCATCTC
TCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGAGTTGCAAAGCACAATTAGGCATAAATGAAATCTC
GGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAGATAGTAGCGATAGTGAGTATATCAGTGATGATGA
GCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGGACAAAGAGCCATCTGCTGTTAAAAAAAAGCCCAA
GCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCGAGAAGGCAGACCCTGGAGCAGTCAAGGACAAGGC
CAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCATAAAGGATAAACTGAAGGGAAAAGATGAGACGGA
TTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAGATTTAGGAGAAGACCATTCTGGGCGGGAGGGTCG
AAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGGGCTGTAATCCCCTTGCACAAACCGGCCGGAGTAAATTGCAGAATC
AAAGAGCTGCTTTGAATCAGCAGATCCTGAAAGCCGTGCGGATGAGGACCGGAGCGGAAAACCTTCTGAAAGTGGCCACAAACTCAAAGG
TGCGGGAGCAAGTGCGGCTGGAGCTGAGCTTCGTCAACTCAGACCTGCAGATGCTCAAGGAAGAGCTGGAGGGGCTGAACATCTCGGTGG
GCGTCTATCAGAACACAGAGGAGGCATTTACGATTCCCCTGATTCCTCTTGGCCTGAAGGAAACGAAAGACGTCGACTTTGCAGTCGTCC
TCAAGGATTTTATCCTGGAACATTACAGTGAAGATGGCTATTTATATGAAGATGAAATTGCAGATCTTATGGATCTGAGACAAGCTTGTC
GGACGCCTAGCCGGGATGAGGCCGGGGTGGAACTGCTGATGACATACTTCATCCAGCTGGGCTTTGTCGAGAGTCGATTCTTCCCGCCCA
CACGGCAGATGGGACTCCTGTTCACCTGGTATGACTCTCTCACCGGGGTTCCGGTCAGCCAGCAGAACCTGCTGCTGGAGAAGGCCAGTG
TCCTGTTCAACACTGGGGCCCTCTACACCCAGATTGGGACCCGGTGTGATCGGCAGACGCAGGCTGGGCTGGAGAGTGCCATAGATGCCT
TTCAGAGAGCCGCAGGGGTTTTAAATTACCTGAAAGACACATTTACCCATACTCCAAGTTACGACATGAGCCCTGCCATGCTCAGCGTGC
TCGTCAAAATGATGCTTGCACAAGCCCAAGAAAGCGTGTTTGAGAAAATCAGCCTTCCTGGGATCCGGAATGAATTCTTCATGCTGGTGA
AGGTGGCTCAGGAGGCTGCTAAGGTGGGAGAGGTCTACCAACAGCTACACGCAGCCATGAGCCAGGCGCCGGTGAAAGAGAACATCCCCT
ACTCCTGGGCCAGCTTAGCCTGCGTGAAGGCCCACCACTACGCGGCCCTGGCCCACTACTTCACTGCCATCCTCCTCATCGACCACCAGG
TGAAGCCAGGCACGGATCTGGACCACCAGGAGAAGTGCCTGTCCCAGCTCTACGACCACATGCCAGAGGGGCTGACACCCTTGGCCACAC
TGAAGAATGATCAGCAGCGCCGACAGCTGGGGAAGTCCCACTTGCGCAGAGCCATGGCTCATCACGAGGAGTCGGTGCGGGAGGCCAGCC
TCTGCAAGAAGCTGCGGAGCATTGAGGTGCTACAGAAGGTGCTGTGTGCCGCACAGGAACGCTCCCGGCTCACGTACGCCCAGCACCAGG
AGGAGGATGACCTGCTGAACCTGATCGACGCCCCCAGTGTTGTTGCTAAAACTGAGCAAGAGGTTGACATTATATTGCCCCAGTTCTCCA
AGCTGACAGTCACGGACTTCTTCCAGAAGCTGGGCCCCTTATCTGTGTTTTCGGCTAACAAGCGGTGGACGCCTCCTCGAAGCATCCGCT
TCACTGCAGAAGAAGGGGACTTGGGGTTCACCTTGAGAGGGAACGCCCCCGTTCAGGTTCACTTCCTGGATCCTTACTGCTCTGCCTCGG
TGGCAGGAGCCCGGGAAGGAGATTATATTGTCTCCATTCAGCTTGTGGATTGTAAGTGGCTGACGCTGAGTGAGGTTATGAAGCTGCTGA
AGAGCTTTGGCGAGGACGAGATCGAGATGAAAGTCGTGAGCCTCCTGGACTCCACATCATCCATGCATAATAAGAGTGCCACATACTCCG
TGGGAATGCAGAAAACGTACTCCATGATCTGCTTAGCCATTGATGATGACGACAAAACTGATAAAACCAAGAAAATCTCCAAGAAGCTTT
CCTTCCTGAGTTGGGGCACCAACAAGAACAGACAGAAGTCAGCCAGCACCTTGTGCCTCCCATCGGTCGGGGCTGCACGGCCTCAGGTCA
AGAAGAAGCTGCCCTCCCCTTTCAGCCTTCTCAACTCAGACAGTTCTTGGTACTAATGTGAGGAAACAAACATGTTCAGGCCCTGAACAT
TTCCGGTGCTGACTCGGCCTTAAACGTTTGTGCCATAATGGAAAATATCTATCTATCTGTTCTCAAATCCTGTTTTTCTCATAGTGTAAA
CTCACATTTGATGTGTTTTTATGAAGGAAAGTAACCAAGAAACCTCTAGGAATTAGTGAAAAAAGAACTTTTTTGAGGTGTGTTACTATA
CTGCTGTAAGTTATTTATTATATAAAGTATTGTAAATAGAATAGTGTTGAAGATATGAAATATGGCTATTTTTAATGGTGACAATTATGA
CTTTTAGTCACTATTAAATTGGGGTTACCTATATCAGTACAATTTGTAGTTGTTTCCAGGTTTGGCTAATAATCATTCCTTAACCTAGAA
TTCAGATGATCCTGGAATTAAGGCAGGTCAGAGGACTGTAATGATAGAATTAAATTAGTGTCACTAAAAACTGTCCCAAAGTGCTGCTTC
CTAATAGGAATTCATTAACCTAAAACAAGATGTTACTATTATATCGATAGACTATGAATGCTATTTCTAGAAAAAGTCTAGTGCCAAATT
TGTCTTATTAAATAAAAACAATGTAGGAGCAGCTTTTCTTCTAGTTTGATGTCATTTAAGAATTACTAACACAGTGGCAGTGTTAGATGA
AGATGCTGTCTACAAGGTAGATAATATACTGTTTGATACTCAAAACATTTTTCATTTTGTTTAAAGTAGAAGTTACATAATTCTATATTT
TAAGTCTTGGGTAAAAAAGTAGTTTTACATTTTATAAAGTAAAGATGTAAATGATTCAGGTTTAAAGCTCTATTTGACTTCCTTTTTTTG
TTTGAGATAGCGTCTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCAGTGCAACCTCCGCCCCCTGGGATCAAGCGA
TTCTCCTACCTCAGCCTCCCAAATAGCTGGGACTACAAGGTGCCCTCCAGCATGCCTGGCTGATTTTTGTATTTTTAGTTGAGGTGAGGT
TTCACCATGTTGGCCAGGCGGGTTTCGAAATCCTGACCTCAAATGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGA
GCCACCACAACCGTCCCACTATTTTACTTTTTAAAATGACATTCCTACTGATTGATTTTTATCTTGCTATAAGTTCGATGACACCGTGAA
TCTAATAAGGTTCACTGTTGACACAGTACAAGTTACATAGCTAAAATACATAGCATTGAAGACTAATTTTAAGGATTGACAAGAGTTTAT
TTTCTATTGTGCAATATCTTAAAGGAAGCAACCACCTTTGGGAAAGTGTATCTGCTGCTCCTAGGGCCATGCTTGTATACATATTTAAAT

>101412_101412_2_ZMYND8-RHPN2_ZMYND8_chr20_45874751_ENST00000355972_RHPN2_chr19_33535270_ENST00000254260_length(amino acids)=758AA_BP=
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT
DPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKM
KQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVC
PECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQE
MEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMS
TNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKA
EMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPE
DTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGL

--------------------------------------------------------------
>101412_101412_3_ZMYND8-RHPN2_ZMYND8_chr20_45874751_ENST00000446994_RHPN2_chr19_33535270_ENST00000254260_length(transcript)=5519nt_BP=2124nt
GTTAATTCTCAGGCTCTGTTGGGGGTGGTCAGAAATCTAATTTCTTGGCTGAAGAGGAAATAAAAACAGAACAGGAGGTGGTAGAGGGCA
TGGATATCTCTACTCGCTCCAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTCCACATTCTTCCAATG
GCCACTCGCCGCAGGACACATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATAAGGAGCAGGATGGAC
GGAATGATTTCTACTGCTGGGTTTGTCACCGGGAAGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGA
GACTGACATCGGAACCAGAGGGGGACTGGTTTTGTCCTGAATGTGAGACAGATGCATTCCAGAAGCCCGTTCCATTGGAACAGCACCCTG
ACTATGCGGAATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAATGTATGGCTGCACAGAAGCCTTCC
TGGCTGATGCAAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGCAAATAGCGAAAGTAGTCATCAAAA
TCTGTGAACATGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAACGAGATAACTGGTTTTGTGAGCCTT
GTAGCAATCCACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTCTAAGGGATAAAGACGGGCAGGTCG
ATGCCCGATTCTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTAAAGAAATTCCTTTTTCTGTGAAAA
AGACTAAGAGCATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGAAGTTTGGGGTTTTTAATTACTCTC
CATTTAGGACACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCGCCGGCACTGCCAAGATAGACAAGC
AGGAGAAGGTCAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGCTGAGTGGGGGCACAGGCCGCCGGA
TTTCCTTGTCGGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACGTGGAGCAGGATGCTGAGAAGAAGG
CCACGTCGAGCCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCACCAGCCTCCACCAAGACGGGACAAG
CAGGGAGTTTATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAACGGACAAAACCTCCACCACCGGCA
GCATCCTGAATCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGGTCCAGCAACAGTCCACCCCTGTTC
CTCTCATCTCTCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGAGTTGCAAAGCACAATTAGGCATAA
ATGAAATCTCGGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAGATAGTAGCGATAGTGAGTATATCA
GTGATGATGAGCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGGACAAAGAGCCATCTGCTGTTAAAA
AAAAGCCCAAGCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCGAGAAGGCAGACCCTGGAGCAGTCA
AGGACAAGGCCAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCATAAAGGATAAACTGAAGGGAAAAG
ATGAGACGGATTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAGATTTAGGAGAAGACCATTCTGGGC
GGGAGGGTCGAAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGGGCTGTAATCCCCTTGCACAAACCGGCCGGAGTAAA
TTGCAGAATCAAAGAGCTGCTTTGAATCAGCAGATCCTGAAAGCCGTGCGGATGAGGACCGGAGCGGAAAACCTTCTGAAAGTGGCCACA
AACTCAAAGGTGCGGGAGCAAGTGCGGCTGGAGCTGAGCTTCGTCAACTCAGACCTGCAGATGCTCAAGGAAGAGCTGGAGGGGCTGAAC
ATCTCGGTGGGCGTCTATCAGAACACAGAGGAGGCATTTACGATTCCCCTGATTCCTCTTGGCCTGAAGGAAACGAAAGACGTCGACTTT
GCAGTCGTCCTCAAGGATTTTATCCTGGAACATTACAGTGAAGATGGCTATTTATATGAAGATGAAATTGCAGATCTTATGGATCTGAGA
CAAGCTTGTCGGACGCCTAGCCGGGATGAGGCCGGGGTGGAACTGCTGATGACATACTTCATCCAGCTGGGCTTTGTCGAGAGTCGATTC
TTCCCGCCCACACGGCAGATGGGACTCCTGTTCACCTGGTATGACTCTCTCACCGGGGTTCCGGTCAGCCAGCAGAACCTGCTGCTGGAG
AAGGCCAGTGTCCTGTTCAACACTGGGGCCCTCTACACCCAGATTGGGACCCGGTGTGATCGGCAGACGCAGGCTGGGCTGGAGAGTGCC
ATAGATGCCTTTCAGAGAGCCGCAGGGGTTTTAAATTACCTGAAAGACACATTTACCCATACTCCAAGTTACGACATGAGCCCTGCCATG
CTCAGCGTGCTCGTCAAAATGATGCTTGCACAAGCCCAAGAAAGCGTGTTTGAGAAAATCAGCCTTCCTGGGATCCGGAATGAATTCTTC
ATGCTGGTGAAGGTGGCTCAGGAGGCTGCTAAGGTGGGAGAGGTCTACCAACAGCTACACGCAGCCATGAGCCAGGCGCCGGTGAAAGAG
AACATCCCCTACTCCTGGGCCAGCTTAGCCTGCGTGAAGGCCCACCACTACGCGGCCCTGGCCCACTACTTCACTGCCATCCTCCTCATC
GACCACCAGGTGAAGCCAGGCACGGATCTGGACCACCAGGAGAAGTGCCTGTCCCAGCTCTACGACCACATGCCAGAGGGGCTGACACCC
TTGGCCACACTGAAGAATGATCAGCAGCGCCGACAGCTGGGGAAGTCCCACTTGCGCAGAGCCATGGCTCATCACGAGGAGTCGGTGCGG
GAGGCCAGCCTCTGCAAGAAGCTGCGGAGCATTGAGGTGCTACAGAAGGTGCTGTGTGCCGCACAGGAACGCTCCCGGCTCACGTACGCC
CAGCACCAGGAGGAGGATGACCTGCTGAACCTGATCGACGCCCCCAGTGTTGTTGCTAAAACTGAGCAAGAGGTTGACATTATATTGCCC
CAGTTCTCCAAGCTGACAGTCACGGACTTCTTCCAGAAGCTGGGCCCCTTATCTGTGTTTTCGGCTAACAAGCGGTGGACGCCTCCTCGA
AGCATCCGCTTCACTGCAGAAGAAGGGGACTTGGGGTTCACCTTGAGAGGGAACGCCCCCGTTCAGGTTCACTTCCTGGATCCTTACTGC
TCTGCCTCGGTGGCAGGAGCCCGGGAAGGAGATTATATTGTCTCCATTCAGCTTGTGGATTGTAAGTGGCTGACGCTGAGTGAGGTTATG
AAGCTGCTGAAGAGCTTTGGCGAGGACGAGATCGAGATGAAAGTCGTGAGCCTCCTGGACTCCACATCATCCATGCATAATAAGAGTGCC
ACATACTCCGTGGGAATGCAGAAAACGTACTCCATGATCTGCTTAGCCATTGATGATGACGACAAAACTGATAAAACCAAGAAAATCTCC
AAGAAGCTTTCCTTCCTGAGTTGGGGCACCAACAAGAACAGACAGAAGTCAGCCAGCACCTTGTGCCTCCCATCGGTCGGGGCTGCACGG
CCTCAGGTCAAGAAGAAGCTGCCCTCCCCTTTCAGCCTTCTCAACTCAGACAGTTCTTGGTACTAATGTGAGGAAACAAACATGTTCAGG
CCCTGAACATTTCCGGTGCTGACTCGGCCTTAAACGTTTGTGCCATAATGGAAAATATCTATCTATCTGTTCTCAAATCCTGTTTTTCTC
ATAGTGTAAACTCACATTTGATGTGTTTTTATGAAGGAAAGTAACCAAGAAACCTCTAGGAATTAGTGAAAAAAGAACTTTTTTGAGGTG
TGTTACTATACTGCTGTAAGTTATTTATTATATAAAGTATTGTAAATAGAATAGTGTTGAAGATATGAAATATGGCTATTTTTAATGGTG
ACAATTATGACTTTTAGTCACTATTAAATTGGGGTTACCTATATCAGTACAATTTGTAGTTGTTTCCAGGTTTGGCTAATAATCATTCCT
TAACCTAGAATTCAGATGATCCTGGAATTAAGGCAGGTCAGAGGACTGTAATGATAGAATTAAATTAGTGTCACTAAAAACTGTCCCAAA
GTGCTGCTTCCTAATAGGAATTCATTAACCTAAAACAAGATGTTACTATTATATCGATAGACTATGAATGCTATTTCTAGAAAAAGTCTA
GTGCCAAATTTGTCTTATTAAATAAAAACAATGTAGGAGCAGCTTTTCTTCTAGTTTGATGTCATTTAAGAATTACTAACACAGTGGCAG
TGTTAGATGAAGATGCTGTCTACAAGGTAGATAATATACTGTTTGATACTCAAAACATTTTTCATTTTGTTTAAAGTAGAAGTTACATAA
TTCTATATTTTAAGTCTTGGGTAAAAAAGTAGTTTTACATTTTATAAAGTAAAGATGTAAATGATTCAGGTTTAAAGCTCTATTTGACTT
CCTTTTTTTGTTTGAGATAGCGTCTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCAGTGCAACCTCCGCCCCCTGG
GATCAAGCGATTCTCCTACCTCAGCCTCCCAAATAGCTGGGACTACAAGGTGCCCTCCAGCATGCCTGGCTGATTTTTGTATTTTTAGTT
GAGGTGAGGTTTCACCATGTTGGCCAGGCGGGTTTCGAAATCCTGACCTCAAATGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATT
ACAGGCATGAGCCACCACAACCGTCCCACTATTTTACTTTTTAAAATGACATTCCTACTGATTGATTTTTATCTTGCTATAAGTTCGATG
ACACCGTGAATCTAATAAGGTTCACTGTTGACACAGTACAAGTTACATAGCTAAAATACATAGCATTGAAGACTAATTTTAAGGATTGAC
AAGAGTTTATTTTCTATTGTGCAATATCTTAAAGGAAGCAACCACCTTTGGGAAAGTGTATCTGCTGCTCCTAGGGCCATGCTTGTATAC

>101412_101412_3_ZMYND8-RHPN2_ZMYND8_chr20_45874751_ENST00000446994_RHPN2_chr19_33535270_ENST00000254260_length(amino acids)=695AA_BP=
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCHREGQV
LCCELCPRVYHAKCLRLTSEPEGDWFCPECETDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYN
GGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPI
NNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPK
ILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQL
SAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSD
SEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEK

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Fusion Gene PPI Analysis for ZMYND8-RHPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-152475_406741.33333333333341169.0histone H3K14ac
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-142275_406741.33333333333341187.0histone H3K14ac
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-142275_406761.33333333333341161.0histone H3K14ac
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-152475_406741.33333333333341215.0histone H3K14ac
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-142275_406736.33333333333341136.0histone H3K14ac
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-142375_406761.33333333333341189.0histone H3K14ac
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-142375_406761.33333333333341235.0histone H3K14ac
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-152475_268741.33333333333341169.0histone H3K4me0
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-142275_268741.33333333333341187.0histone H3K4me0
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-142275_268761.33333333333341161.0histone H3K4me0
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-152475_268741.33333333333341215.0histone H3K4me0
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-142275_268736.33333333333341136.0histone H3K4me0
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-142375_268761.33333333333341189.0histone H3K4me0
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-142375_268761.33333333333341235.0histone H3K4me0
TgeneRHPN2chr20:45874751chr19:33535270ENST0000025426001546_6623.0687.0Rho


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZMYND8chr20:45874751chr19:33535270ENST00000262975-15241147_1186741.33333333333341169.0PRKCB1
HgeneZMYND8chr20:45874751chr19:33535270ENST00000311275-14221147_1186741.33333333333341187.0PRKCB1
HgeneZMYND8chr20:45874751chr19:33535270ENST00000352431-14221147_1186761.33333333333341161.0PRKCB1
HgeneZMYND8chr20:45874751chr19:33535270ENST00000355972-15241147_1186741.33333333333341215.0PRKCB1
HgeneZMYND8chr20:45874751chr19:33535270ENST00000360911-14221147_1186736.33333333333341136.0PRKCB1
HgeneZMYND8chr20:45874751chr19:33535270ENST00000461685-14231147_1186761.33333333333341189.0PRKCB1
HgeneZMYND8chr20:45874751chr19:33535270ENST00000471951-14231147_1186761.33333333333341235.0PRKCB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZMYND8-RHPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZMYND8-RHPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource