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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZMYND8-RNF114 (FusionGDB2 ID:101413)

Fusion Gene Summary for ZMYND8-RNF114

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYND8-RNF114
Fusion gene ID: 101413
HgeneTgene
Gene symbol

ZMYND8

RNF114

Gene ID

23613

55905

Gene namezinc finger MYND-type containing 8ring finger protein 114
SynonymsPRKCBP1|PRO2893|RACK7PSORS12|ZNF313
Cytomap

20q13.12

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8E3 ubiquitin-protein ligase RNF114RING-type E3 ubiquitin transferase RNF114zinc finger protein 228zinc finger protein 313
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000468376, ENST00000262975, 
ENST00000352431, ENST00000355972, 
ENST00000360911, ENST00000372023, 
ENST00000396281, ENST00000446994, 
ENST00000458360, ENST00000461685, 
ENST00000471951, ENST00000536340, 
ENST00000540497, ENST00000311275, 
ENST00000244061, 
Fusion gene scores* DoF score25 X 23 X 10=57509 X 9 X 5=405
# samples 3410
** MAII scorelog2(34/5750*10)=-4.0799553045814
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZMYND8 [Title/Abstract] AND RNF114 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYND8(45915972)-RNF114(48568612), # samples:1
Anticipated loss of major functional domain due to fusion event.ZMYND8-RNF114 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZMYND8-RNF114 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZMYND8-RNF114 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ZMYND8-RNF114 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZMYND8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RNF114 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A9FOZMYND8chr20

45915972

-RNF114chr20

48568612

+


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Fusion Gene ORF analysis for ZMYND8-RNF114

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000468376ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000262975ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000352431ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000355972ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000360911ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000372023ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000396281ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000446994ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000458360ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000461685ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000471951ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000536340ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
Frame-shiftENST00000540497ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+
In-frameENST00000311275ENST00000244061ZMYND8chr20

45915972

-RNF114chr20

48568612

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311275ZMYND8chr2045915972-ENST00000244061RNF114chr2048568612+28159982091063284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311275ENST00000244061ZMYND8chr2045915972-RNF114chr2048568612+0.0008597630.99914026

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Fusion Genomic Features for ZMYND8-RNF114


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZMYND8chr2045915972-RNF114chr2048568612+1.34E-070.9999999
ZMYND8chr2045915972-RNF114chr2048568612+1.34E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZMYND8-RNF114


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:45915972/chr20:48568612)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-92443_472481169.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-82243_472481187.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-82243_472681161.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-92443_472481215.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-82243_472431136.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-82343_472681189.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-82343_472681235.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-924165_2352481169.0DomainBromo
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-822165_2352481187.0DomainBromo
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-822165_2352681161.0DomainBromo
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-924165_2352481215.0DomainBromo
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-822165_2352431136.0DomainBromo
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-823165_2352681189.0DomainBromo
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-823165_2352681235.0DomainBromo
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-92488_1332481169.0Zinc fingerPHD-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-82288_1332481187.0Zinc fingerPHD-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-82288_1332681161.0Zinc fingerPHD-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-92488_1332481215.0Zinc fingerPHD-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-82288_1332431136.0Zinc fingerPHD-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-82388_1332681189.0Zinc fingerPHD-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-82388_1332681235.0Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-9241089_10922481169.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-924838_8542481169.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-8221089_10922481187.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-822838_8542481187.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-8221089_10922681161.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-822838_8542681161.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-9241089_10922481215.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-924838_8542481215.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-8221089_10922431136.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-822838_8542431136.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-8231089_10922681189.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-823838_8542681189.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-8231089_10922681235.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-823838_8542681235.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-924277_3272481169.0DomainPWWP
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-822277_3272481187.0DomainPWWP
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-822277_3272681161.0DomainPWWP
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-924277_3272481215.0DomainPWWP
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-822277_3272431136.0DomainPWWP
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-823277_3272681189.0DomainPWWP
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-823277_3272681235.0DomainPWWP
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-9241028_10622481169.0Zinc fingerMYND-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-8221028_10622481187.0Zinc fingerMYND-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-8221028_10622681161.0Zinc fingerMYND-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-9241028_10622481215.0Zinc fingerMYND-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-8221028_10622431136.0Zinc fingerMYND-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-8231028_10622681189.0Zinc fingerMYND-type
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-8231028_10622681235.0Zinc fingerMYND-type
TgeneRNF114chr20:45915972chr20:48568612ENST000002440614629_68207229.0Zinc fingerRING-type
TgeneRNF114chr20:45915972chr20:48568612ENST000002440614691_110207229.0Zinc fingerC2HC RNF-type


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Fusion Gene Sequence for ZMYND8-RNF114


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101413_101413_1_ZMYND8-RNF114_ZMYND8_chr20_45915972_ENST00000311275_RNF114_chr20_48568612_ENST00000244061_length(transcript)=2815nt_BP=998nt
GGAGTGTAGAGGAAATAAAATCATGTCTGTGGCTCATGACAGCATTCCATATTCAGTTGTTGGGTTGTGTTGTTGTTGTTGTGTGTGTTT
TTAATAATACCATGTAACTGTTTAAAAAAATTTCCTTTTTGATCAAGTCCCAAATCTGCCAGCCTGTTCTCTCTTCCTAACTGTGGAAAA
ATGAGACGGTTGCTTGAACATTTGTTGGCTTGGCTGAAGAGGAAATAAAAACAGAACAGGAGGTGGTAGAGGGCATGGATATCTCTACTC
GCTCCAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTCCACATTCTTCCAATGGCCACTCGCCGCAGG
ACACATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATAAGGAGCAGTCAGAACTAAGACATGGTCCGT
TTTACTATATGAAGCAGCCACTCACCACAGACCCTGTTGATGTTGTACCGCAGGATGGACGGAATGATTTCTACTGCTGGGTTTGTCACC
GGGAAGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGAGACTGACATCGGAACCAGAGGGGGACTGGT
TTTGTCCTGAATGTGAGAAAATTACAGTAGCAGAATGCATCGAGACCCAGAGTAAAGCCATGACAATGCTCACCATTGAACAGTTATCCT
ACCTGCTCAAGTTTGCCATTCAGAAAATGAAACAGCCAGGGACAGATGCATTCCAGAAGCCCGTTCCATTGGAACAGCACCCTGACTATG
CGGAATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAATGTATGGCTGCACAGAAGCCTTCCTGGCTG
ATGCAAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGCAAATAGCGAAAGTAGTCATCAAAATCTGTG
AACATGAGGATTATGATGTTGATGAAGAGGACATGATGAATCAGGTGTTGCAGCGCTCCATCATCGACCAGTGAGCAGAGTCCGTGCTTG
CTATCTGTCTCATGTTACAGAGCTTCCATTACATATTAAACGTGAAATCTATGACTCCTGTACCTTACCTGTTCAACAGACCTGAAAATG
AGCCATGGCATTGGGACAGGGTCACTTCTGACAGGGGAAGTGGGTCCCCAGGTCAGCCCTTCTCTTCCCTTTGGGCTCTTGCCAAAGCTG
TCTTCCCCTACTGTTAACCTTGTTTGTCACACGGTCGAGTTCGTATTGGTTCTCGGCTACTTCCTGGAGCTTCTGCCGCCTCCTGTGGAA
GATAATCTAGCTTCTCCACCTCTTGTTTCACACTCATTCCTCCCATCCAGTGTTTGTCTCTCGGGTCCTTCAAGCCAGCCAGGACCTTTT
CTGGGTCATGAATAGCACAATGAAGCAAGTGTCTCCTTTCCTTGTCCCCAAGGTGTGCAGACTTTGGCAGCCGTGCACCTGACCAGAGCT
GAAGCTCCCGCTGGGCTGTGGGGTTGCCAGAAGCTGGGGTTGCCATCCCGGGGTACATGTCACCAGTCCTCTTGGGGTTTTGTACCATCT
GATGCTGGAAGTTTTGATTAGTGATATTTTCTACTACTACATATTTAGAGTTCACTGGTTCAGTCTTAAATGCCTGCATGGTGCCTTTTT
AGGATAAGGTATAACCATACATTTTTGGTGGAAGTGTTTCTGGGTTAGGGAAGTTAAAGTCTGTTTATCCGTAAGTGGGGAGGAGGGTCA
GCTAAGAGAAGTGGGAGGGCCAGAGCTTTTTGGTTCTGATTTACAAATTAATGAAGTAGTTTCAAACAACGCGGTCATGTTTACCTCTCC
ATTTGGGAGCCTGCCTACATTCTTGTTCTAGAAGCACAAAAAATCCTCAGATGAATTAGAAGAAAGAGGTTTGGGGACTCAGCGGATACT
AGTTCTTTTACCTTCTGCTTGGTAACTTAGATTAAACTGAGCATTGTTTTTCTGTCACAAATGTTTTCCTTATGACACTGGTTTCGACAT
GTAAAATGTGTTTGAAAACCTGCTTTGTAGATGCAGAGAGAAGCTATAGGAAACCCAGTACCACCCCTGGTCTGTTCTGACGAGACATCG
TTCATAAGGCACAGCACATCGCAAGATGAACAGTTGTTAATAAAAGCTGTTGCTGGAAACTTGCTTTAGGAACAGCTCAAGAACCTTGGA
GTTCATATTTCACAAATATTAATAAATATAAGTCCAAGAGCTGTCAGCCTAATCTGTAGGAGCAGAACCTCTGATTGACCAAAAGGCATA
TGGGTTTAGGTTGGTTTTTTGATGTCATATGTCTCTGATGGGGCTGCAAGTGCTACCTCGCGCTTGTACACTGCTGCTGTGGGGCTCCGC
GCCTGCCGGTGAAGAGCTGCAGATGCCGAGAAGCCAGCAAACACAGGGCCCACTGGAAAAAAATAGTTTTTTCATTAGTATTTCTCGGGA
GGACCCAAAAGTTAAGGTCAGCTTGTTCACTGTAATTTCTGGAAGAAGTTCACTCAGACCTTCCTGAATTCAGATCATCTCAGAAGTCTG
GAGGGAAATCTGGCGAAACCTTCGTTTGAGGGACTGATGTGAGTGTATGTCCACCTCACTGGTGGCACCGAGAAACTTACTTCCTTGTAT
TAAGTGCACTTCTTGTATTTCTAATAAGATGACTTTCCAGAAAGTGAGATTTGTTATGTTCTGGCTTTTAAAAGGTAAAATATAAATAAA

>101413_101413_1_ZMYND8-RNF114_ZMYND8_chr20_45915972_ENST00000311275_RNF114_chr20_48568612_ENST00000244061_length(amino acids)=284AA_BP=263
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT
DPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKM
KQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEDYDVDEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZMYND8-RNF114


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-82275_268268.01161.0histone H3K4me0
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-82375_268268.01189.0histone H3K4me0
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-82375_268268.01235.0histone H3K4me0


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-92475_406248.01169.0histone H3K14ac
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-82275_406248.01187.0histone H3K14ac
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-82275_406268.01161.0histone H3K14ac
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-92475_406248.01215.0histone H3K14ac
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-82275_406243.01136.0histone H3K14ac
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-82375_406268.01189.0histone H3K14ac
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-82375_406268.01235.0histone H3K14ac
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-92475_268248.01169.0histone H3K4me0
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-82275_268248.01187.0histone H3K4me0
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-92475_268248.01215.0histone H3K4me0
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-82275_268243.01136.0histone H3K4me0
HgeneZMYND8chr20:45915972chr20:48568612ENST00000262975-9241147_1186248.01169.0PRKCB1
HgeneZMYND8chr20:45915972chr20:48568612ENST00000311275-8221147_1186248.01187.0PRKCB1
HgeneZMYND8chr20:45915972chr20:48568612ENST00000352431-8221147_1186268.01161.0PRKCB1
HgeneZMYND8chr20:45915972chr20:48568612ENST00000355972-9241147_1186248.01215.0PRKCB1
HgeneZMYND8chr20:45915972chr20:48568612ENST00000360911-8221147_1186243.01136.0PRKCB1
HgeneZMYND8chr20:45915972chr20:48568612ENST00000461685-8231147_1186268.01189.0PRKCB1
HgeneZMYND8chr20:45915972chr20:48568612ENST00000471951-8231147_1186268.01235.0PRKCB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZMYND8-RNF114


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZMYND8-RNF114


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource