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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF106-CNTLN (FusionGDB2 ID:101433)

Fusion Gene Summary for ZNF106-CNTLN

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF106-CNTLN
Fusion gene ID: 101433
HgeneTgene
Gene symbol

ZNF106

CNTLN

Gene ID

64397

54875

Gene namezinc finger protein 106centlein
SynonymsSH3BP3|ZFP106|ZNF474C9orf101|C9orf39|bA340N12.1
Cytomap

15q15.1

9p22.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 106SH3-domain binding protein 3zinc finger protein 474centleincentlein, centrosomal proteincentrosomal protein
Modification date2020031320200320
UniProtAcc.

Q9NXG0

Ensembl transtripts involved in fusion geneENST00000263805, ENST00000565380, 
ENST00000565611, ENST00000565660, 
ENST00000380641, ENST00000484374, 
ENST00000262360, ENST00000380647, 
ENST00000425824, 
Fusion gene scores* DoF score10 X 10 X 5=5009 X 9 X 6=486
# samples 119
** MAII scorelog2(11/500*10)=-2.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF106 [Title/Abstract] AND CNTLN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF106(42749156)-CNTLN(17415786), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF106 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNTLN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-BF-AAP2-01AZNF106chr15

42749156

-CNTLNchr9

17415786

+


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Fusion Gene ORF analysis for ZNF106-CNTLN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263805ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
5CDS-intronENST00000263805ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+
In-frameENST00000263805ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
In-frameENST00000263805ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
In-frameENST00000263805ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565380ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565380ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565380ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565611ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565611ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565611ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565660ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565660ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565660ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565380ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565380ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565611ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565611ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565660ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565660ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263805ZNF106chr1542749156-ENST00000380647CNTLNchr917415786+32715756321999455
ENST00000263805ZNF106chr1542749156-ENST00000262360CNTLNchr917415786+19975756321996455
ENST00000263805ZNF106chr1542749156-ENST00000425824CNTLNchr917415786+32655756321999455

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263805ENST00000380647ZNF106chr1542749156-CNTLNchr917415786+0.0007433250.9992567
ENST00000263805ENST00000262360ZNF106chr1542749156-CNTLNchr917415786+0.0028251960.99717474
ENST00000263805ENST00000425824ZNF106chr1542749156-CNTLNchr917415786+0.0007329580.99926704

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Fusion Genomic Features for ZNF106-CNTLN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF106chr1542749155-CNTLNchr917415785+3.07E-050.99996924
ZNF106chr1542749155-CNTLNchr917415785+3.07E-050.99996924

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF106-CNTLN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:42749156/chr9:17415786)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CNTLN

Q9NXG0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for centrosome cohesion and recruitment of CEP68 to centrosomes. {ECO:0000269|PubMed:24554434}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-11920_44821884.0Zinc fingerNote=C2H2-type 1%3B atypical
TgeneCNTLNchr15:42749156chr9:17415786ENST0000038064107613_6550392.0Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST0000038064107681_7930392.0Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST000003806410795_1260392.0Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST0000038064107980_13110392.0Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST000003806471526980_13119321407.0Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380641071398_14050392.0Compositional biasNote=Poly-Ser
TgeneCNTLNchr15:42749156chr9:17415786ENST0000038064715261398_14059321407.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191529_1568821884.0RepeatNote=WD 1
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191570_1611821884.0RepeatNote=WD 2
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191654_1695821884.0RepeatNote=WD 3
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191698_1737821884.0RepeatNote=WD 4
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191738_1775821884.0RepeatNote=WD 5
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191778_1815821884.0RepeatNote=WD 6
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181529_156801069.0RepeatNote=WD 1
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181570_161101069.0RepeatNote=WD 2
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181654_169501069.0RepeatNote=WD 3
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181698_173701069.0RepeatNote=WD 4
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181738_177501069.0RepeatNote=WD 5
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181778_181501069.0RepeatNote=WD 6
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191813_1838821884.0Zinc fingerNote=C2H2-type 2%3B atypical
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181813_183801069.0Zinc fingerNote=C2H2-type 2%3B atypical
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-11820_4401069.0Zinc fingerNote=C2H2-type 1%3B atypical
TgeneCNTLNchr15:42749156chr9:17415786ENST000003806471526613_6559321407.0Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST000003806471526681_7939321407.0Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380647152695_1269321407.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ZNF106-CNTLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101433_101433_1_ZNF106-CNTLN_ZNF106_chr15_42749156_ENST00000263805_CNTLN_chr9_17415786_ENST00000262360_length(transcript)=1997nt_BP=575nt
GAGTGCAGCTGGCACCATGGGTGTGCTCCAGAGCAACTTCTGCTTGCTCTGAGCCCCCTGCCCTGCCTCCCCTTTCACCATGTTTCCTCT
GACAAGATTTTAAGTACAGCAATTCAAGAAGATTTCTCCTCCTAAACGACATTTATCTGAAGTCTATTGCCTCTTGATTGCTGGAAAAGA
ATCTTAAAATCATTTCAAAAGTAACTTATAAACAAACTTATTAAAAGTGATGAAAGGAGCATTGAAATTAATTAGCACTAATTTTTCACT
GTGCCAAAGTGTGCAGTGTCCTTCAGAGGAAACAATAACAGATCTGGTGAGTGTGCCATGCCAGTGGGGAGAATTGAATGTCCCTCATCT
CCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTGGGTCTTTCTGCATATGCAAAGCACATTTCTGGC
CAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAGGAAGAGGAAGAAGATTATTTTGACAAGGAACTC
ATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATGCCAAAAAACCAACTTTTCAAAAGAAGAATTGCA
AGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACAAAAATATAACTGCCCAGAAATCAAGTAGCAATA
TTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGAATGCCAAGAAAACAGCAGAATTGTCTGTTAAAG
AATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGATTTCAGACAAGCAGGCAGACAATAAAGAAGCTAA
ATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGTCCTCATCTGAAATCACAAGTTTGGCAGAAGAAA
ATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCATGGATTTGGAAATGAAGCAATTGCAGTATAAAC
TAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAATTTGAACTCCTAGCAAAAGAAGAACACATAAAGG
AAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGATAGAGGACTTGAAATTTCGACAGAAAGTAAATT
TGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGACATTAACTGAAGAATGTTCCAACAAGAAGGTAT
CAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATGAACAGATGTATCAGAAATCTAAAGAGGAGTTAG
AAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTGCAATGGCAGAAATTGAAACAGCAGCATCTAAGC
AGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACATTGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCA
CCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGCGACAAATAAGAGAGCTTAAAAAAATGAAGAAAA
ACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCCTGAACATTTCACGGTCAGATTTAGAGGAAATAT
TAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACAAGGAATGGATGTTGTACATTCAGAAACTTCTTG
AAGGACAGAGTCTTGCTCTGTCTCCCAGGCTGAAGTGCAATGGCGCAATCGTGGCTCACCAAAACCTCCGCCTGCCAGACTCGAGCAGTT

>101433_101433_1_ZNF106-CNTLN_ZNF106_chr15_42749156_ENST00000263805_CNTLN_chr9_17415786_ENST00000262360_length(amino acids)=455AA_BP=
MQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLN
LDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKE
MHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELE
KKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKN
RDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQSLALSPRLKCNGAIVAHQNLRLPDSSSS

--------------------------------------------------------------
>101433_101433_2_ZNF106-CNTLN_ZNF106_chr15_42749156_ENST00000263805_CNTLN_chr9_17415786_ENST00000380647_length(transcript)=3271nt_BP=575nt
GAGTGCAGCTGGCACCATGGGTGTGCTCCAGAGCAACTTCTGCTTGCTCTGAGCCCCCTGCCCTGCCTCCCCTTTCACCATGTTTCCTCT
GACAAGATTTTAAGTACAGCAATTCAAGAAGATTTCTCCTCCTAAACGACATTTATCTGAAGTCTATTGCCTCTTGATTGCTGGAAAAGA
ATCTTAAAATCATTTCAAAAGTAACTTATAAACAAACTTATTAAAAGTGATGAAAGGAGCATTGAAATTAATTAGCACTAATTTTTCACT
GTGCCAAAGTGTGCAGTGTCCTTCAGAGGAAACAATAACAGATCTGGTGAGTGTGCCATGCCAGTGGGGAGAATTGAATGTCCCTCATCT
CCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTGGGTCTTTCTGCATATGCAAAGCACATTTCTGGC
CAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAGGAAGAGGAAGAAGATTATTTTGACAAGGAACTC
ATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATGCCAAAAAACCAACTTTTCAAAAGAAGAATTGCA
AGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACAAAAATATAACTGCCCAGAAATCAAGTAGCAATA
TTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGAATGCCAAGAAAACAGCAGAATTGTCTGTTAAAG
AATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGATTTCAGACAAGCAGGCAGACAATAAAGAAGCTAA
ATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGTCCTCATCTGAAATCACAAGTTTGGCAGAAGAAA
ATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCATGGATTTGGAAATGAAGCAATTGCAGTATAAAC
TAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAATTTGAACTCCTAGCAAAAGAAGAACACATAAAGG
AAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGATAGAGGACTTGAAATTTCGACAGAAAGTAAATT
TGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGACATTAACTGAAGAATGTTCCAACAAGAAGGTAT
CAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATGAACAGATGTATCAGAAATCTAAAGAGGAGTTAG
AAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTGCAATGGCAGAAATTGAAACAGCAGCATCTAAGC
AGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACATTGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCA
CCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGCGACAAATAAGAGAGCTTAAAAAAATGAAGAAAA
ACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCCTGAACATTTCACGGTCAGATTTAGAGGAAATAT
TAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACAAGGAATGGATGTTGTACATTCAGAAACTTCTTG
AAGGACAGCTTCCTTTTGCCTCATATTTACTAGAAGCAGTACTGGAAAAAATAAATGAAAAAAAGAAACTAGTTGAAGGATATTTCACAA
TTATGAAAGATATTAGATGATATTAAAATGGAGAGCTTTATTGCAAATGTGAAAACTTTTTATGTGGTGTGATTGGAATACATGCATTGC
AATCCTGACACGGTATCTGCTCCAACTATCAATAGTCAGGTTCAATACCAAAATAAGAAGTCTCTGAAAATAATTAATTGCTGAACAAGT
GAAACTAATTAAGTACATAGCCATTTAAAAGGAAATAGTGTAGCATCTGATGGTCGAATACAAATATTGCCACAAATCAGTGCAAACTTA
AAAATGATTTTCCTTCTAGTGCATTAAAAGAAACTGAGCAGGCTTGGTACACACAAATTGGCCTGAGCATAAGAAGAAAAAGTATCAACT
AAGGATTTAATGTTTTACGTTTCATGAAGAAACTAGACTTTTTACATAAAACTGCTATAGATGGCCATAAGTGGTCCAGGGAGCAACAGA
TTTGTAGTATGAGCAAATATAAAATGAAGCATCATAACTTGAGCATTTATTGAAATAAATTGTGTGGTCCAATTGAATCTGTTCTCATTG
ATGTGCTGGTTTATGTAGGAGATACTGTGTATTTCTACAACTCTTTGGCAAAAACAAAAACATTTTCTTCTTCTCTCTCTTAACTTCACA
ATACTATACGTTGTGTAGTCATATAAATTTGCAGGGAACCACAAACCCAATGTATAAAATTAGGCTCTATTTAACAGAACTACTACTGTG
GTCAGCTAATTTAAGTTACATTCTTAACCATGATGTCATCCTTATTTAGATTCCTGGACATTCCCACCTCATTTCACCTCTTCACCGTGT
TCCTGCCATACCCTTTTTGGTTCCTCTAATTCACCATACTGGTGCCTGCCTCCCACATTTGCCCTTGGTCTTCTCTCTTTCTAGAATACT
CTGCACTCAACTTTCCTCATGGCTGGCTCCTTGTCATCATTCAGCTCCACCTTCCCCGGTCCCTCAGAGACACATTCTCTGACCAGCTTA
CTATTTTATTTCCTCATAGCACAAAATTATCTATCTGTTCATGTATTTGTTTTCTTGTTTATTTTCTTCTTTTCCCTCTTTAGTATGTAG
GTCCCATGAGATTAAGGCAAGGGTTGGCAGATTATAGCCTGCAGGGCGAATCTGGCCTGCCACCTGTTTTGTATGGCCCACAAGCTAAGA
ATGGTTTTTGCCTTATTAAATGGTTTTTAAAAAATCAAAAGGAGAATAATATTTTGTAGCATGTGAAAATTATATAAAATTCAAATTTTG

>101433_101433_2_ZNF106-CNTLN_ZNF106_chr15_42749156_ENST00000263805_CNTLN_chr9_17415786_ENST00000380647_length(amino acids)=455AA_BP=
MQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLN
LDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKE
MHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELE
KKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKN
RDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKLVEGYFTI

--------------------------------------------------------------
>101433_101433_3_ZNF106-CNTLN_ZNF106_chr15_42749156_ENST00000263805_CNTLN_chr9_17415786_ENST00000425824_length(transcript)=3265nt_BP=575nt
GAGTGCAGCTGGCACCATGGGTGTGCTCCAGAGCAACTTCTGCTTGCTCTGAGCCCCCTGCCCTGCCTCCCCTTTCACCATGTTTCCTCT
GACAAGATTTTAAGTACAGCAATTCAAGAAGATTTCTCCTCCTAAACGACATTTATCTGAAGTCTATTGCCTCTTGATTGCTGGAAAAGA
ATCTTAAAATCATTTCAAAAGTAACTTATAAACAAACTTATTAAAAGTGATGAAAGGAGCATTGAAATTAATTAGCACTAATTTTTCACT
GTGCCAAAGTGTGCAGTGTCCTTCAGAGGAAACAATAACAGATCTGGTGAGTGTGCCATGCCAGTGGGGAGAATTGAATGTCCCTCATCT
CCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTGGGTCTTTCTGCATATGCAAAGCACATTTCTGGC
CAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAGGAAGAGGAAGAAGATTATTTTGACAAGGAACTC
ATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATGCCAAAAAACCAACTTTTCAAAAGAAGAATTGCA
AGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACAAAAATATAACTGCCCAGAAATCAAGTAGCAATA
TTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGAATGCCAAGAAAACAGCAGAATTGTCTGTTAAAG
AATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGATTTCAGACAAGCAGGCAGACAATAAAGAAGCTAA
ATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGTCCTCATCTGAAATCACAAGTTTGGCAGAAGAAA
ATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCATGGATTTGGAAATGAAGCAATTGCAGTATAAAC
TAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAATTTGAACTCCTAGCAAAAGAAGAACACATAAAGG
AAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGATAGAGGACTTGAAATTTCGACAGAAAGTAAATT
TGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGACATTAACTGAAGAATGTTCCAACAAGAAGGTAT
CAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATGAACAGATGTATCAGAAATCTAAAGAGGAGTTAG
AAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTGCAATGGCAGAAATTGAAACAGCAGCATCTAAGC
AGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACATTGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCA
CCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGCGACAAATAAGAGAGCTTAAAAAAATGAAGAAAA
ACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCCTGAACATTTCACGGTCAGATTTAGAGGAAATAT
TAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACAAGGAATGGATGTTGTACATTCAGAAACTTCTTG
AAGGACAGCTTCCTTTTGCCTCATATTTACTAGAAGCAGTACTGGAAAAAATAAATGAAAAAAAGAAACTAGTTGAAGGATATTTCACAA
TTATGAAAGATATTAGATGATATTAAAATGGAGAGCTTTATTGCAAATGTGAAAACTTTTTATGTGGTGTGATTGGAATACATGCATTGC
AATCCTGACACGGTATCTGCTCCAACTATCAATAGTCAGGTTCAATACCAAAATAAGAAGTCTCTGAAAATAATTAATTGCTGAACAAGT
GAAACTAATTAAGTACATAGCCATTTAAAAGGAAATAGTGTAGCATCTGATGGTCGAATACAAATATTGCCACAAATCAGTGCAAACTTA
AAAATGATTTTCCTTCTAGTGCATTAAAAGAAACTGAGCAGGCTTGGTACACACAAATTGGCCTGAGCATAAGAAGAAAAAGTATCAACT
AAGGATTTAATGTTTTACGTTTCATGAAGAAACTAGACTTTTTACATAAAACTGCTATAGATGGCCATAAGTGGTCCAGGGAGCAACAGA
TTTGTAGTATGAGCAAATATAAAATGAAGCATCATAACTTGAGCATTTATTGAAATAAATTGTGTGGTCCAATTGAATCTGTTCTCATTG
ATGTGCTGGTTTATGTAGGAGATACTGTGTATTTCTACAACTCTTTGGCAAAAACAAAAACATTTTCTTCTTCTCTCTCTTAACTTCACA
ATACTATACGTTGTGTAGTCATATAAATTTGCAGGGAACCACAAACCCAATGTATAAAATTAGGCTCTATTTAACAGAACTACTACTGTG
GTCAGCTAATTTAAGTTACATTCTTAACCATGATGTCATCCTTATTTAGATTCCTGGACATTCCCACCTCATTTCACCTCTTCACCGTGT
TCCTGCCATACCCTTTTTGGTTCCTCTAATTCACCATACTGGTGCCTGCCTCCCACATTTGCCCTTGGTCTTCTCTCTTTCTAGAATACT
CTGCACTCAACTTTCCTCATGGCTGGCTCCTTGTCATCATTCAGCTCCACCTTCCCCGGTCCCTCAGAGACACATTCTCTGACCAGCTTA
CTATTTTATTTCCTCATAGCACAAAATTATCTATCTGTTCATGTATTTGTTTTCTTGTTTATTTTCTTCTTTTCCCTCTTTAGTATGTAG
GTCCCATGAGATTAAGGCAAGGGTTGGCAGATTATAGCCTGCAGGGCGAATCTGGCCTGCCACCTGTTTTGTATGGCCCACAAGCTAAGA
ATGGTTTTTGCCTTATTAAATGGTTTTTAAAAAATCAAAAGGAGAATAATATTTTGTAGCATGTGAAAATTATATAAAATTCAAATTTTG

>101433_101433_3_ZNF106-CNTLN_ZNF106_chr15_42749156_ENST00000263805_CNTLN_chr9_17415786_ENST00000425824_length(amino acids)=455AA_BP=
MQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLN
LDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKE
MHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELE
KKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKN
RDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKLVEGYFTI

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Fusion Gene PPI Analysis for ZNF106-CNTLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF106-CNTLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF106-CNTLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource