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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF136-NFIC (FusionGDB2 ID:101484)

Fusion Gene Summary for ZNF136-NFIC

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF136-NFIC
Fusion gene ID: 101484
HgeneTgene
Gene symbol

ZNF136

NFIC

Gene ID

7695

4782

Gene namezinc finger protein 136nuclear factor I C
SynonymspHZ-20CTF|CTF5|NF-I|NFI
Cytomap

19p13.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 136nuclear factor 1 C-typeCCAAT-box-binding transcription factorNF-I/CNF1-CTGGCA-binding proteinnuclear factor I/C (CCAAT-binding transcription factor)
Modification date2020031320200313
UniProtAcc.

P08651

Ensembl transtripts involved in fusion geneENST00000343979, ENST00000398616, 
ENST00000588839, ENST00000341919, 
ENST00000346156, ENST00000395111, 
ENST00000443272, ENST00000586919, 
ENST00000589123, ENST00000590282, 
Fusion gene scores* DoF score8 X 2 X 6=9624 X 21 X 9=4536
# samples 1027
** MAII scorelog2(10/96*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(27/4536*10)=-4.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF136 [Title/Abstract] AND NFIC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF136(12274021)-NFIC(3381709), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFIC

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

TgeneNFIC

GO:0045944

positive regulation of transcription by RNA polymerase II

1524678|19706729


check buttonFusion gene breakpoints across ZNF136 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NFIC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7604ZNF136chr19

12274021

+NFICchr19

3381709

+


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Fusion Gene ORF analysis for ZNF136-NFIC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343979ENST00000588839ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-3CDSENST00000398616ENST00000341919ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-3CDSENST00000398616ENST00000346156ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-3CDSENST00000398616ENST00000395111ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-3CDSENST00000398616ENST00000443272ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-3CDSENST00000398616ENST00000586919ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-3CDSENST00000398616ENST00000589123ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-3CDSENST00000398616ENST00000590282ZNF136chr19

12274021

+NFICchr19

3381709

+
5UTR-intronENST00000398616ENST00000588839ZNF136chr19

12274021

+NFICchr19

3381709

+
In-frameENST00000343979ENST00000341919ZNF136chr19

12274021

+NFICchr19

3381709

+
In-frameENST00000343979ENST00000346156ZNF136chr19

12274021

+NFICchr19

3381709

+
In-frameENST00000343979ENST00000395111ZNF136chr19

12274021

+NFICchr19

3381709

+
In-frameENST00000343979ENST00000443272ZNF136chr19

12274021

+NFICchr19

3381709

+
In-frameENST00000343979ENST00000586919ZNF136chr19

12274021

+NFICchr19

3381709

+
In-frameENST00000343979ENST00000589123ZNF136chr19

12274021

+NFICchr19

3381709

+
In-frameENST00000343979ENST00000590282ZNF136chr19

12274021

+NFICchr19

3381709

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343979ZNF136chr1912274021+ENST00000589123NFICchr193381709+80881431401639499
ENST00000343979ZNF136chr1912274021+ENST00000346156NFICchr193381709+22501431401360406
ENST00000343979ZNF136chr1912274021+ENST00000395111NFICchr193381709+18591431401432430
ENST00000343979ZNF136chr1912274021+ENST00000586919NFICchr193381709+13611431401360407
ENST00000343979ZNF136chr1912274021+ENST00000341919NFICchr193381709+15981431401399419
ENST00000343979ZNF136chr1912274021+ENST00000590282NFICchr193381709+16171431401432430
ENST00000343979ZNF136chr1912274021+ENST00000443272NFICchr193381709+17781431401639499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343979ENST00000589123ZNF136chr1912274021+NFICchr193381709+0.0050448130.9949551
ENST00000343979ENST00000346156ZNF136chr1912274021+NFICchr193381709+0.0255340280.9744659
ENST00000343979ENST00000395111ZNF136chr1912274021+NFICchr193381709+0.0272777970.9727222
ENST00000343979ENST00000586919ZNF136chr1912274021+NFICchr193381709+0.0333616030.9666384
ENST00000343979ENST00000341919ZNF136chr1912274021+NFICchr193381709+0.0272745530.97272545
ENST00000343979ENST00000590282ZNF136chr1912274021+NFICchr193381709+0.0283992370.97160083
ENST00000343979ENST00000443272ZNF136chr1912274021+NFICchr193381709+0.0322388520.96776116

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Fusion Genomic Features for ZNF136-NFIC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF136chr1912274021+NFICchr193381709+1.65E-161
ZNF136chr1912274021+NFICchr193381709+1.65E-161

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZNF136-NFIC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12274021/chr19:3381709)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NFIC

P08651

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNFICchr19:12274021chr19:3381709ENST00000346156091_1951669.0DNA bindingCTF/NF-I
TgeneNFICchr19:12274021chr19:3381709ENST000003951110101_1951548.3333333333334DNA bindingCTF/NF-I
TgeneNFICchr19:12274021chr19:3381709ENST00000586919081_1951407.0DNA bindingCTF/NF-I
TgeneNFICchr19:12274021chr19:3381709ENST000005891230111_1951500.0DNA bindingCTF/NF-I
TgeneNFICchr19:12274021chr19:3381709ENST0000034191909404_41210429.0Motif9aaTAD
TgeneNFICchr19:12274021chr19:3381709ENST0000034615609404_4121669.0Motif9aaTAD
TgeneNFICchr19:12274021chr19:3381709ENST00000395111010404_4121548.3333333333334Motif9aaTAD
TgeneNFICchr19:12274021chr19:3381709ENST00000443272011404_41210509.0Motif9aaTAD
TgeneNFICchr19:12274021chr19:3381709ENST0000058691908404_4121407.0Motif9aaTAD
TgeneNFICchr19:12274021chr19:3381709ENST00000589123011404_4121500.0Motif9aaTAD
TgeneNFICchr19:12274021chr19:3381709ENST00000590282010404_41210461.6666666666667Motif9aaTAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+144_901541.0DomainKRAB
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14140_1621541.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14168_1901541.0Zinc fingerC2H2-type 2
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14196_2181541.0Zinc fingerC2H2-type 3
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14224_2461541.0Zinc fingerC2H2-type 4
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14252_2741541.0Zinc fingerC2H2-type 5
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14280_3021541.0Zinc fingerC2H2-type 6
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14308_3301541.0Zinc fingerC2H2-type 7
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14336_3581541.0Zinc fingerC2H2-type 8
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14364_3861541.0Zinc fingerC2H2-type 9
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14392_4141541.0Zinc fingerC2H2-type 10
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14420_4421541.0Zinc fingerC2H2-type 11
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14448_4701541.0Zinc fingerC2H2-type 12
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14476_4981541.0Zinc fingerC2H2-type 13
HgeneZNF136chr19:12274021chr19:3381709ENST00000343979+14504_5261541.0Zinc fingerC2H2-type 14
TgeneNFICchr19:12274021chr19:3381709ENST00000341919091_19510429.0DNA bindingCTF/NF-I
TgeneNFICchr19:12274021chr19:3381709ENST000004432720111_19510509.0DNA bindingCTF/NF-I
TgeneNFICchr19:12274021chr19:3381709ENST000005902820101_19510461.6666666666667DNA bindingCTF/NF-I


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Fusion Gene Sequence for ZNF136-NFIC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>101484_101484_1_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000341919_length(transcript)=1598nt_BP=143nt
TTTCTCGCGTCTGCCGTACTTGGTTTCGCTTCGCTAGTCCCAGAGGCCCAGAGTGGCTCGCCTGGAGTCTCTGTGGCGCGGTTTCCTGTA
CCTGCCTTGGGATCCGGAGGGAGGAAGCTGGGACACCCGGGAGTCAGGAAATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTC
ACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACG
AGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGG
ACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGG
GCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGC
TGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCG
TCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACC
AGGAGGACAGCAAGCCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCC
AAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAG
CCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACA
CGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGGCATCTCGT
CCCCGGTGAAGAAGACAGAGATGGACAAGTCACCATTCAACAGCCCGTCCCCCCAGGACTCTCCCCGCCTCTCCAGCTTCACCCAGCACC
ACCGGCCCGTCATCGCCGTGCACAGCGGGATCGCCCGGAGCCCACACCCGTCCTCCGCTCTGCATTTCCCTACGACGTCCATCCTACCCC
AGACGGCCTCCACCTACTTCCCCCACACGGCCATCCGCTACCCACCTCATCTCAACCCCCAGGACCCGCTCAAAGATCTTGTCTCGCTGG
CCTGCGACCCAGCCAGCCAGCAACCTGGACCGTCCTGGTATCTGGGATAGCAAAGGTCTTCTTCCCTCGCCCCTTCTCCATCGTCCCAGG
AATCCCAGGGGGCAGCACAGCCGGCCCCCGGCCCACGTTTTCGGTGGAAAATTAGAGTGAACAAGAACACCCCTGCCGACTCCCAGCCCG

>101484_101484_1_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000341919_length(amino acids)=419AA_BP=1
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA
EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGS
KRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP

--------------------------------------------------------------
>101484_101484_2_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000346156_length(transcript)=2250nt_BP=143nt
TTTCTCGCGTCTGCCGTACTTGGTTTCGCTTCGCTAGTCCCAGAGGCCCAGAGTGGCTCGCCTGGAGTCTCTGTGGCGCGGTTTCCTGTA
CCTGCCTTGGGATCCGGAGGGAGGAAGCTGGGACACCCGGGAGTCAGGAAATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTC
ACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACG
AGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGG
ACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGG
GCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGC
TGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCG
TCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCA
GCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGG
CATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGA
TGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACA
TGGAAGGAGGCATCTCGTCCCCGGTGAAGAAGACAGAGATGGACAAGTCACCATTCAACAGCCCGTCCCCCCAGGACTCTCCCCGCCTCT
CCAGCTTCACCCAGCACCACCGGCCCGTCATCGCCGTGCACAGCGGGATCGCCCGGAGCCCACACCCGTCCTCCGCTCTGCATTTCCCTA
CGACGTCCATCCTACCCCAGACGGCCTCCACCTACTTCCCCCACACGGCCATCCGCTACCCACCTCATCTCAACCCCCAGGACCCGCTCA
AAGATCTTGTCTCGCTGGCCTGCGACCCAGCCAGCCAGCAACCTGGACCGCCTACTCTCCGCCCGACACGTCCCCTGCAAACCGTTCCTT
TGTGGGATTAGGACCAAGGGATCCTGCGGGCATTTATCAGGCACAGTCCTGGTATCTGGGATAGCAAAGGTCTTCTTCCCTCGCCCCTTC
TCCATCGTCCCAGGAATCCCAGGGGGCAGCACAGCCGGCCCCCGGCCCACGTTTTCGGTGGAAAATTAGAGTGAACAAGAACACCCCTGC
CGACTCCCAGCCCGGCCAAAAAGACAAAACACATAGACGCACACACTCAGGAGGAAAAGAAAAAACAAAGGCAGAAGAAGAAGAAGAAGA
AATAAAAACCCACCCAAGCAAGAAGACAAAAGGTAAAGACGCAACGTTTCCAACTCTCGGGACGCCAAGGCCGCAGGACTGGAGGGCCAG
GCCCCGCCACCCCCACGGGAGACCCGGGACAGGGCGTCTTCCTAAGTTATTCATCTCCTCTCCGCCTGCTGCTCGGGAAGGACAGACGCC
GGCCGCCCGCCCGCGCCCCGGAGGCCCTGGCTCTGTCCGGAGACCAGGTGAGCACAGCCTGGAGCCTGTGCCCAGGGCCGACAGGCGCGA
CACCCAGCAAGGCCACCTCTCCCCGGGCCCCCGCGCCTCTGCCGGACACGGACCGGCCCCTCAGCCCCCACCGAGGACGCAGCCACTGGG
GGGAAAGGGAGACACAGCGGACCCCGGCCGGGCAGCGGAGACCGCAGAGGCGGGCAGGGTGGGGCAGGCGAGTGGTGTCGCGGGGGTGCG
TGGCGCTTGCGAGCCCTGGCCAGGGGAGGAAGTGAGGCCCAGGCACCTGCTGCCCCTCGAGGGGGCCCTGCCTGCCGCGGGGCCTCCCCA
CAAGCCCCTCCCAAAGCGCCGGCCGACTCGCTGTCTCGCTGGGGACTCTTTCAGCCCTCGCGCCCGCCCGTTTGGGAGGAGAAGTCTCTA

>101484_101484_2_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000346156_length(amino acids)=406AA_BP=1
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDT
TDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSP
SSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTA

--------------------------------------------------------------
>101484_101484_3_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000395111_length(transcript)=1859nt_BP=143nt
TTTCTCGCGTCTGCCGTACTTGGTTTCGCTTCGCTAGTCCCAGAGGCCCAGAGTGGCTCGCCTGGAGTCTCTGTGGCGCGGTTTCCTGTA
CCTGCCTTGGGATCCGGAGGGAGGAAGCTGGGACACCCGGGAGTCAGGAAATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTC
ACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACG
AGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGG
ACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGG
GCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGC
TGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCG
TCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACC
AGGAGGACAGCAAGCCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCC
AAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAG
CCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACA
CGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGGCATCTCGT
CCCCGGTGAAGAAGACAGAGATGGACAAGTCACCATTCAACAGCCCGTCCCCCCAGGACTCTCCCCGCCTCTCCAGCTTCACCCAGCACC
ACCGGCCCGTCATCGCCGTGCACAGCGGGATCGCCCGGAGCCCACACCCGTCCTCCGCTCTGCATTTCCCTACGACGTCCATCCTACCCC
AGACGGCCTCCACCTACTTCCCCCACACGGCCATCCGCTACCCACCTCATCTCAACCCCCAGGACCCGCTCAAAGATCTTGTCTCGCTGG
CCTGCGACCCAGCCAGCCAGCAACCTGGACCGCCTACTCTCCGCCCGACACGTCCCCTGCAAACCGTTCCTTTGTGGGATTAGGACCAAG
GGATCCTGCGGGCATTTATCAGGCACAGTCCTGGTATCTGGGATAGCAAAGGTCTTCTTCCCTCGCCCCTTCTCCATCGTCCCAGGAATC
CCAGGGGGCAGCACAGCCGGCCCCCGGCCCACGTTTTCGGTGGAAAATTAGAGTGAACAAGAACACCCCTGCCGACTCCCAGCCCGGCCA
AAAAGACAAAACACATAGACGCACACACTCAGGAGGAAAAGAAAAAACAAAGGCAGAAGAAGAAGAAGAAGAAATAAAAACCCACCCAAG
CAAGAAGACAAAAGGTAAAGACGCAACGTTTCCAACTCTCGGGACGCCAAGGCCGCAGGACTGGAGGGCCAGGCCCCGCCACCCCCACGG

>101484_101484_3_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000395111_length(amino acids)=430AA_BP=1
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA
EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGS
KRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP

--------------------------------------------------------------
>101484_101484_4_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000443272_length(transcript)=1778nt_BP=143nt
TTTCTCGCGTCTGCCGTACTTGGTTTCGCTTCGCTAGTCCCAGAGGCCCAGAGTGGCTCGCCTGGAGTCTCTGTGGCGCGGTTTCCTGTA
CCTGCCTTGGGATCCGGAGGGAGGAAGCTGGGACACCCGGGAGTCAGGAAATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTC
ACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACG
AGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGG
ACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGG
GCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGC
TGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCG
TCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACC
AGGAGGACAGCAAGCCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCC
AAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAG
CCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACA
CGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGGCATCTCGT
CCCCGGTGAAGAAGACAGAGATGGACAAGTCACCATTCAACAGCCCGTCCCCCCAGGACTCTCCCCGCCTCTCCAGCTTCACCCAGCACC
ACCGGCCCGTCATCGCCGTGCACAGCGGGATCGCCCGGAGCCCACACCCGTCCTCCGCTCTGCATTTCCCTACGACGTCCATCCTACCCC
AGACGGCCTCCACCTACTTCCCCCACACGGCCATCCGCTACCCACCTCATCTCAACCCCCAGGACCCGCTCAAAGATCTTGTCTCGCTGG
CCTGCGACCCAGCCAGCCAGCAACCTGGACCGTTAAATGGAAGTGGTCAGCTCAAAATGCCCAGCCACTGCCTTTCTGCTCAGATGCTGG
CACCTCCGCCCCCGGGGCTGCCACGGCTGGCGCTCCCCCCTGCCACCAAACCCGCCACCACCTCCGAGGGAGGAGCCACGTCGCCGACCT
CGCCTTCCTACTCTCCGCCCGACACGTCCCCTGCAAACCGTTCCTTTGTGGGATTAGGACCAAGGGATCCTGCGGGCATTTATCAGGCAC
AGTCCTGGTATCTGGGATAGCAAAGGTCTTCTTCCCTCGCCCCTTCTCCATCGTCCCAGGAATCCCAGGGGGCAGCACAGCCGGCCCCCG

>101484_101484_4_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000443272_length(amino acids)=499AA_BP=1
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA
EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGS
KRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP
SSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATK

--------------------------------------------------------------
>101484_101484_5_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000586919_length(transcript)=1361nt_BP=143nt
TTTCTCGCGTCTGCCGTACTTGGTTTCGCTTCGCTAGTCCCAGAGGCCCAGAGTGGCTCGCCTGGAGTCTCTGTGGCGCGGTTTCCTGTA
CCTGCCTTGGGATCCGGAGGGAGGAAGCTGGGACACCCGGGAGTCAGGAAATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTC
ACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACG
AGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGG
ACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGG
GCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGC
TGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCG
TCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCA
GCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGG
CATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGA
TGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACA
TGGAAGGAGGCATCTCGTCCCCGGTGAAGAAGACAGAGATGGACAAGTCACCATTCAACAGCCCGTCCCCCCAGGACTCTCCCCGCCTCT
CCAGCTTCACCCAGCACCACCGGCCCGTCATCGCCGTGCACAGCGGGATCGCCCGGAGCCCACACCCGTCCTCCGCTCTGCATTTCCCTA
CGACGTCCATCCTACCCCAGACGGCCTCCACCTACTTCCCCCACACGGCCATCCGCTACCCACCTCATCTCAACCCCCAGGACCCGCTCA
AAGATCTTGTCTCGCTGGCCTGCGACCCAGCCAGCCAGCAACCTGGACCGCCTACTCTCCGCCCGACACGTCCCCTGCAAACCGTTCCTT

>101484_101484_5_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000586919_length(amino acids)=407AA_BP=1
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDT
TDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSP
SSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTA

--------------------------------------------------------------
>101484_101484_6_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000589123_length(transcript)=8088nt_BP=143nt
TTTCTCGCGTCTGCCGTACTTGGTTTCGCTTCGCTAGTCCCAGAGGCCCAGAGTGGCTCGCCTGGAGTCTCTGTGGCGCGGTTTCCTGTA
CCTGCCTTGGGATCCGGAGGGAGGAAGCTGGGACACCCGGGAGTCAGGAAATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTC
ACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACG
AGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGG
ACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGG
GCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGC
TGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCG
TCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACC
AGGAGGACAGCAAGCCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCC
AAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAG
CCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACA
CGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGGCATCTCGT
CCCCGGTGAAGAAGACAGAGATGGACAAGTCACCATTCAACAGCCCGTCCCCCCAGGACTCTCCCCGCCTCTCCAGCTTCACCCAGCACC
ACCGGCCCGTCATCGCCGTGCACAGCGGGATCGCCCGGAGCCCACACCCGTCCTCCGCTCTGCATTTCCCTACGACGTCCATCCTACCCC
AGACGGCCTCCACCTACTTCCCCCACACGGCCATCCGCTACCCACCTCATCTCAACCCCCAGGACCCGCTCAAAGATCTTGTCTCGCTGG
CCTGCGACCCAGCCAGCCAGCAACCTGGACCGTTAAATGGAAGTGGTCAGCTCAAAATGCCCAGCCACTGCCTTTCTGCTCAGATGCTGG
CACCTCCGCCCCCGGGGCTGCCACGGCTGGCGCTCCCCCCTGCCACCAAACCCGCCACCACCTCCGAGGGAGGAGCCACGTCGCCGACCT
CGCCTTCCTACTCTCCGCCCGACACGTCCCCTGCAAACCGTTCCTTTGTGGGATTAGGACCAAGGGATCCTGCGGGCATTTATCAGGCAC
AGTCCTGGTATCTGGGATAGCAAAGGTCTTCTTCCCTCGCCCCTTCTCCATCGTCCCAGGAATCCCAGGGGGCAGCACAGCCGGCCCCCG
GCCCACGTTTTCGGTGGAAAATTAGAGTGAACAAGAACACCCCTGCCGACTCCCAGCCCGGCCAAAAAGACAAAACACATAGACGCACAC
ACTCAGGAGGAAAAGAAAAAACAAAGGCAGAAGAAGAAGAAGAAGAAATAAAAACCCACCCAAGCAAGAAGACAAAAGGTAAAGACGCAA
CGTTTCCAACTCTCGGGACGCCAAGGCCGCAGGACTGGAGGGCCAGGCCCCGCCACCCCCACGGGAGACCCGGGACAGGGCGTCTTCCTA
AGTTATTCATCTCCTCTCCGCCTGCTGCTCGGGAAGGACAGACGCCGGCCGCCCGCCCGCGCCCCGGAGGCCCTGGCTCTGTCCGGAGAC
CAGGTGAGCACAGCCTGGAGCCTGTGCCCAGGGCCGACAGGCGCGACACCCAGCAAGGCCACCTCTCCCCGGGCCCCCGCGCCTCTGCCG
GACACGGACCGGCCCCTCAGCCCCCACCGAGGACGCAGCCACTGGGGGGAAAGGGAGACACAGCGGACCCCGGCCGGGCAGCGGAGACCG
CAGAGGCGGGCAGGGTGGGGCAGGCGAGTGGTGTCGCGGGGGTGCGTGGCGCTTGCGAGCCCTGGCCAGGGGAGGAAGTGAGGCCCAGGC
ACCTGCTGCCCCTCGAGGGGGCCCTGCCTGCCGCGGGGCCTCCCCACAAGCCCCTCCCAAAGCGCCGGCCGACTCGCTGTCTCGCTGGGG
ACTCTTTCAGCCCTCGCGCCCGCCCGTTTGGGAGGAGAAGTCTCTATGCAATTGGCCCCGGCCCCTCCACCCCCCACCCCCGGCATAGGA
GGCCCCCCCACCTCGCCCGGCTCACACCCCCAAAGGGAGGGACCCACATTGCACACACTGTAAGAAATGCACTTTCCGAGGAAGGGGATG
GGGGAGCCCGGACACCCAGAGCTCCCCGAGTTGGGGGTGCCCGTCTGGAGCGCCCCCGTCAGCCCCTGGCGGTGGGAGGTGAGAGCGAGT
GGTTTAAGTGCCTGATTACCACCACCCGCCCCCCCCTTTGTCCAGCTGGGACACGGAATGGCCGCGGGCCTCCTCCCCCTCCCCTCCAGC
CTCTCCACCAGCCCCTCCAGTCAACCCTCATCGCCGTGCCCCCCCAGAGCTAGAGAGATGGGGCCCCTGCGTGGCCCGAGGGGCAGAGCT
GGGCGTCACTTCGCAAGCGTCCTGCCCTGCCGGGGCGCGGGGGTGGGCTCTGGGGAAGCCGGTGCGCCCCCCACGCCTCCGCTGCCAGTG
CCTTACATTCTGGAGCGACCCCCCTCCCTGGTGCCTCCCAGCGAAGGGGGACCGCCGTTTGCACTTTCATCGCCTACCCCGACGCGGGGC
CCAGCTGCGGGACGTGCATCACGGCTGGGCCCCCAGAGGAGAGAGGAGGCCGACGCCAGCGGTCCCCGCTCGGAACGGGGAGGGTTTTCG
GGGGGTTCGGCGTCGCACCTTGGGGCCCCCCGCAGCCGTGTAGGGGGCCTCCCATCTGCTAAGCGTTTTTCCGTTGAGCCGCTCCAAAAA
CACTAAGCTGGGGACGCCAGGTGCCCCCCCACCCCGGCTCCCTGGCCCTATCCACACCTCCACCCCCACCCCAGGATCGCCATCTTTAGG
GGAGGCCTGGGAGGGGGTGTTAGGTGTTTTAGGGCCACCGAGCTCAAACACAAGGACCCCTCCCCGGCCCACCCAGCCCAGCCCCAACTG
ACCTCCATGCCTAGGGAAAAACTCCCCCCACCACTGCCCCCTCCCCCGACCCAGGCCAAAGCCAGGGCAGGTCTCCGGGTCTCACCTGCT
CCTAGCCTCACCCCCCTGCCCCCGAAAACCAGACTCTCCTCCCAAACTAGCCTCAGGAGCTTGGCGAACCCGCTCGCTCCTAAAGAGAAA
GACCCAGGACCCTCCCCCATCACCCCCAAGAGAGGTTCGCCATCCTCTGGCCTCGAGCCCTTGGTCCCTCCGTCCGTCTGTCCTCGGGGC
CCGCTCCCCCGGTGGCCCTTGGGGATCAAAGCGTGGGCCGCTCTCCGGGAGGGCGGGCGGGGGAGGGGGTGGTCGGGTTGTGCCATTGGG
GTGTCCGGAAGCTTCTCAGCCAGGGTGGGGGTCGTGGAGTGGGGGAGGGAGGCCAGCCGGGCTCCAGAGGGGTCAGGGCGCGACGAGAAC
CAACTCTTTACCTAACTTTGCATGGTGCTTAGTCAAGGACTCCTGCGACCTGGCTCCCGAGGTCAGCTGGCGGCGCTGACACACATGCAT
GGCAGACTATCCCTGGCTCTATCTCCCTGTTCCTCGCCCCCTCCACCCCCCACTTCCTCTTTAAAAAAAAAAAAAAAAAAAAAAAGATAC
AAGAAAAACCTTTAAAAAAATTCCATGTTTCCTAATTTGCACGAAATTTTCTACCACAAGATGTGCCTTGCCTTCCGAGAATAAGTATTA
CCTTTAAACAATATCAGCGCACACACATAGCTGCATGTTCTGCTCGTGTAGTTTAAAAAAAAAAAGACAAAACAGTGACATGAAATAAAA
AATAAAAATTGAAAAGGGATGTATTTCTATTTGTAAAAAAAATAAAATAAAAAATAAGAAAGTGAGAATCTAAAAAAAAAAAAAAAAAAA
AAAAAGGAAGAAAAACCACGCTAAAAATCAAGCCACTGAAAACAATTGCCCCCAGGTCTACCCAGCCCCTGGCTGTCCTTGGTCCTGTCT
CCCCTCCTGCTGTATTCAGGGGTGCCCCCTGGTGCTCAGCCTCTACCACCCCCAACCCTGCTCTTGGGTACCCAGAGGGGTCATTTCTGA
ATCCCTTGCCCAGAGGACAGACCTCCGGGGCCCATCTTGGCCCTGGGAAAGGGCTCTCCTCTCTGATTGGTCCCTAGGCCACGGGCCGGC
CCCCAGACACCATTCACCGACCCACTGCAGGCTGTCCTCCAACCATGGGGTGGCCACTCCACCCGCAGCCAGACTCCCCGCTCCCCACTT
TTCATGCAGGCTGGCATACCCCTGGCTCAGGGTCAAATGCTGTTCCACACCCACCTCAGAGGCACCCCCTCTCCCCTGCCCCGTGCATCC
CCACCCTTCTTGCCAAAGGACCTCTTTTCCCCTATCCAGAGACCACCCCAGGTGGCATTCTCTCCCACCTTCTCCTTTGTCCCCCATCCC
CTGTCTCTGTCTTCCAGCTGTGAATATGAAGGGTATCCTGTATGAAACAAAAACAAAACCTGATATATGCAATATCTGTCTGTCTGTCTG
TACCCATGGGCCTGGCTCAGCCATTGGAGGCCCAGCCGAGGGTCCGGCAGGGCACAGGGACAGCCAGGTGGCACCGAGTCACAGGCTGTG
GTCCGGTGGCTGAGCATGCTGTTGTCTTGTCCTTGATTTTATTTTCTTTTGTTCTTTTTTTTTTTCTTTTCTTTTTGTTTTTAACTCCAG
CTTCCTTTGCTTTTTACTTGACCAAAGCTAAGACAATAGCCAGATGGTTAGTGGGGCAGCCAGGCAGGGAGGACCCAGGGCTGGGATTCT
CCAACCTTAGGCCATTCCTGCAGCCCTCACCACCTCCAGCCCCTCCAAGCATCTCGTGTAGGGACCCACGCAGATGGTCCCATTCATTCA
CTATTGCCCCCAACCCCGGGATTTTGGGTGGTCTCCACAGCCACCATCATACACTCATCCCGTGTTTTCTTCCAAAAAGTCACCTCAGCA
GCCTCCCCAGGCGATACAGAGGGAGAGCCCAGACCACCACAGCTGGCCACGACATTGCCCTTAAGTAATATGCATTGGCCAGAGAGCCCG
GGCTGGCTGTGCACAGCATTCATGTAGCTGATTTCTAGCTTTTTTTTTTTTTCTGCCCCACTCCTGAGCAAATCTGTCTTGCCAAGGAAC
TAGGAGCAACCGGAGGCAAAGGGAGTGGGTGGCCCCATCACTATTGGGACCATCGCGTCCCTGCACAGCCCACACCCGGGGGCCCAGAGT
CCTGGGCTGGACGCCACCCTTCTCACCCCGAGCTTGCCTCCTTGGCTCACTTGGCACCTTGGCTGAGTACAGCAGGCAAAAGCCCATACC
AGGCAGCATGTTGTGGATGGTTTAGTTCTCCCCGCCTCCCTGTTTCTTGGAAAAGCTACAGGGTCCCTGTAGGGCAAAATTCCCAGGCGC
CTTGCTGCAGACAGAGTAAGACAAAAACACCAGGAAGCAGGATTCCGTGCCCATCTCTGCAGTTTGGGTTCACAAAAGGGGGTGCCGTCA
TCCCTGGGTGGAGGAGGGAGTGTTGGTTTTTTGTTTTTGTTTTTTTAACATGTATGAAACTGACATCTTCTCAAATCTTGTTCCACCCCC
CTCTGGAAGCCCCCATCACCCACCCCTGCTATGGACACCACACCTATGCCAGGCCCCCCCCCCCACCCCAGTCTCATTCTGGGGTCTGCC
CATGCTGTGGGAAAGAATAGGGAGGCCTCCCAAATATATGCAAATTGTCCCCATTCCGTGGGGGCACCTGACAATGACCCGGGTGGAGAT
GGGGCATGGAGGAGTAGGAAGACCCAGCCCTATTTGACTGGGGAGAGGAGGATCTGGAGTCCTTCATGCCCAGGTCTGGAACCCAGGTTC
TGACCCCAGGGCCCCACCCTGGGCTGGACAATCAGATCCCAAAGGAATGCCAAAGGGGACTCGGTTGGGAGAGCCGCTTAGGGGCCAGAC
CTGGGTCCCCCTGCAGGTCCCCAGGCAGCAGACAATTCCACCTTCCCTGCCCCAGGACCTTGAGAGACAGCAGCATTCCAGGCACAGACA
GACTTGGCTGCACCCCACTGTCCCTTGCAAGACAGGTTCTGGAGCCAGGAGCAACTGTCCAGCCCTCCAGAAGAGACAGCAAGCAGCCCC
CCTACCCACTCTGGCCTCCCCAATGGTACTTTGACCTCCAGTGTAGGGCTATACTATACATATATATATATATATATATATATATATATA
ATTTTGGAATTTGTTTCTCATAATACAGAATATATAGTGGCTACCTTGTATCTTGGTCTGGATTCTCTCTCTGAGACCCCGGATTTTACT
TTCTCTTTGGAGGGCGCTGGGACATACATCTCTCAATCCAGCTTCCTCCGCATCCTCCCATCTTGCCCCATTTCTGCCACGTCAGACACT
TCCTGAGAGTCTCACCTTCAAAATGACACCGCTGCCCATCCATTGCTCAATGGTACAGAGTGTGGGGTCAGTCCACCACCCTTGACCTCC
CGGCAGGGCAAGGTGAGGAGGCGGACCCAAAGCAGTACCAGCAGGACTTGTTGCCAGTGATACCAAAACAGACTTTTCCCAAGCAGTGCC
TCACATGTCTGCTGGTGTGGCTTTGGGATTCTCCTGCCCCACCCCCCCGTCCATGGCAGCCCCCTCCCCAAGGCTTTGCTCACACCTGAG
ACAGGAAGGAGGAAGGGGATCCAATAGGAATATGGGCCCCGGAGGGGAAGTCATGCACCCCCAAGCCACCACCCCCCAGCCTTCCACGCA
CATCTCCTGGCTGGAAGAGAGCCCTCCAAAAAGGGGACACAGGCTGCCCCGGCCCCTCAACTGCATCCACACCCCATCCTCTCATCTTGG
GTCCCAGCCAGGCCCCCCCAAAACCAAAGCCCCCTCAAGTCCTGGGGTCCCAGCCTGTGCCCCCAGCTTCCTGCCCACCCAGCCCTGAGC
ATTCTCACACAGAGAAAGAACAAGCAAGGGCTCCAGGGGGACAGGATGGGGCAGGGCATACAGTGGGGGGTGGGGGGGCAGCTGGGAGGA
GGGAGGGACAAAACAAAACATTTTCCTTTGGGTTTTTTTTTTCTTTCTTTTTTCTCCCCTTTACTCTTTGGGTGGTGTTGCTTTTCCTTT
CCTTTTCCCTTTGAGATTTTTTTGTTGTTGTTTCCTTTTTGTATTTTACTGATATCACCAGGATAGTTTACTCTCCTTCTAGCTTTCTGC
TTACCGCACACTGGATAACACACACATACACACCCACAAAAATGCTCATGAACCCAATCCGGAGAAGGTTCCAGCAGGTCCCCCACCCTC
CCCTCCTCCTCCTACTTCTCCTCTTGACAGCGAGGACAGGAGGGGGACAAGGGGACACCTGGGCAGACCCGCCGGCTCTCCCCCCACCCC
ACCCCGCCCCTCACATCATACTCCAATCATAACCTTGTATATTATGCAGTCATTTTGGTTTTCGCGGACGCGCCTACCTAAGTACCATTT
ACAGAAAGTGACTCTGGCTGTCATTATTTTGTTTATTTGTTCCCTATGCAAAAAAAAAATGAAAATGAAAAAAGGGGGATTCCATAAAAG

>101484_101484_6_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000589123_length(amino acids)=499AA_BP=1
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA
EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGS
KRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP
SSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATK

--------------------------------------------------------------
>101484_101484_7_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000590282_length(transcript)=1617nt_BP=143nt
TTTCTCGCGTCTGCCGTACTTGGTTTCGCTTCGCTAGTCCCAGAGGCCCAGAGTGGCTCGCCTGGAGTCTCTGTGGCGCGGTTTCCTGTA
CCTGCCTTGGGATCCGGAGGGAGGAAGCTGGGACACCCGGGAGTCAGGAAATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTC
ACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACG
AGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGG
ACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGG
GCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGC
TGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCG
TCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACC
AGGAGGACAGCAAGCCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCC
AAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAG
CCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACA
CGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGGCATCTCGT
CCCCGGTGAAGAAGACAGAGATGGACAAGTCACCATTCAACAGCCCGTCCCCCCAGGACTCTCCCCGCCTCTCCAGCTTCACCCAGCACC
ACCGGCCCGTCATCGCCGTGCACAGCGGGATCGCCCGGAGCCCACACCCGTCCTCCGCTCTGCATTTCCCTACGACGTCCATCCTACCCC
AGACGGCCTCCACCTACTTCCCCCACACGGCCATCCGCTACCCACCTCATCTCAACCCCCAGGACCCGCTCAAAGATCTTGTCTCGCTGG
CCTGCGACCCAGCCAGCCAGCAACCTGGACCGCCTACTCTCCGCCCGACACGTCCCCTGCAAACCGTTCCTTTGTGGGATTAGGACCAAG
GGATCCTGCGGGCATTTATCAGGCACAGTCCTGGTATCTGGGATAGCAAAGGTCTTCTTCCCTCGCCCCTTCTCCATCGTCCCAGGAATC

>101484_101484_7_ZNF136-NFIC_ZNF136_chr19_12274021_ENST00000343979_NFIC_chr19_3381709_ENST00000590282_length(amino acids)=430AA_BP=1
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA
EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGS
KRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF136-NFIC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF136-NFIC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF136-NFIC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource