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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRCA1-NF1 (FusionGDB2 ID:10152)

Fusion Gene Summary for BRCA1-NF1

check button Fusion gene summary
Fusion gene informationFusion gene name: BRCA1-NF1
Fusion gene ID: 10152
HgeneTgene
Gene symbol

BRCA1

NF1

Gene ID

672

4763

Gene nameBRCA1 DNA repair associatedneurofibromin 1
SynonymsBRCAI|BRCC1|BROVCA1|FANCS|IRIS|PNCA4|PPP1R53|PSCP|RNF53NFNS|VRNF|WSS
Cytomap

17q21.31

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionbreast cancer type 1 susceptibility proteinBRCA1/BRCA2-containing complex, subunit 1Fanconi anemia, complementation group SRING finger protein 53breast and ovarian cancer susceptibility protein 1breast cancer 1, early onsetearly onset breast cancer neurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1
Modification date2020032920200322
UniProtAcc

P38398

P21359

Ensembl transtripts involved in fusion geneENST00000309486, ENST00000346315, 
ENST00000351666, ENST00000352993, 
ENST00000354071, ENST00000357654, 
ENST00000468300, ENST00000471181, 
ENST00000491747, ENST00000493795, 
ENST00000586385, ENST00000591534, 
ENST00000591849, 		ENST00000581113, 
ENST00000417592, ENST00000431387, 
ENST00000444181, ENST00000356175, 
ENST00000358273, 
Fusion gene scores* DoF score9 X 8 X 7=50428 X 30 X 15=12600
# samples 933
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/12600*10)=-5.25481389902883
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRCA1 [Title/Abstract] AND NF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRCA1(41199660)-NF1(29654517), # samples:2
NF1(29653270)-BRCA1(41215968), # samples:2
Anticipated loss of major functional domain due to fusion event.BRCA1-NF1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BRCA1-NF1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BRCA1-NF1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
BRCA1-NF1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
BRCA1-NF1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NF1-BRCA1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NF1-BRCA1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NF1-BRCA1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NF1-BRCA1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NF1-BRCA1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRCA1

GO:0000724

double-strand break repair via homologous recombination

17349954

HgeneBRCA1

GO:0006301

postreplication repair

17349954

HgeneBRCA1

GO:0006302

double-strand break repair

22186889

HgeneBRCA1

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

14654789

HgeneBRCA1

GO:0016567

protein ubiquitination

17349954

HgeneBRCA1

GO:0031398

positive regulation of protein ubiquitination

15965487

HgeneBRCA1

GO:0035066

positive regulation of histone acetylation

20820192

HgeneBRCA1

GO:0043627

response to estrogen

8895509

HgeneBRCA1

GO:0045892

negative regulation of transcription, DNA-templated

16288014

HgeneBRCA1

GO:0045893

positive regulation of transcription, DNA-templated

20160719

HgeneBRCA1

GO:0045944

positive regulation of transcription by RNA polymerase II

16331276

HgeneBRCA1

GO:0051571

positive regulation of histone H3-K4 methylation

20820192

HgeneBRCA1

GO:0051573

negative regulation of histone H3-K9 methylation

20820192

HgeneBRCA1

GO:0051865

protein autoubiquitination

12890688|20351172

HgeneBRCA1

GO:0070512

positive regulation of histone H4-K20 methylation

20820192

HgeneBRCA1

GO:0071158

positive regulation of cell cycle arrest

21102443

HgeneBRCA1

GO:0071681

cellular response to indole-3-methanol

10868478

HgeneBRCA1

GO:0085020

protein K6-linked ubiquitination

12890688|20351172

HgeneBRCA1

GO:2000617

positive regulation of histone H3-K9 acetylation

20820192

HgeneBRCA1

GO:2000620

positive regulation of histone H4-K16 acetylation

20820192

TgeneNF1

GO:0043547

positive regulation of GTPase activity

2121371


check buttonFusion gene breakpoints across BRCA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-2A-A8W1-01ABRCA1chr17

41199660

-NF1chr17

29654517

+


Top

Fusion Gene ORF analysis for BRCA1-NF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000309486ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000346315ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000351666ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000352993ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000354071ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000357654ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000468300ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000471181ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000491747ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000493795ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000586385ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000591534ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-3UTRENST00000591849ENST00000581113BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000309486ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000309486ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000309486ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000346315ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000346315ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000346315ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000351666ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000351666ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000351666ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000352993ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000352993ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000352993ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000354071ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000354071ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000354071ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000357654ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000357654ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000357654ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000468300ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000468300ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000468300ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000471181ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000471181ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000471181ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000491747ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000491747ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000491747ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000493795ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000493795ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000493795ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000586385ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000586385ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000586385ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000591534ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000591534ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000591534ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000591849ENST00000417592BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000591849ENST00000431387BRCA1chr17

41199660

-NF1chr17

29654517

+
5CDS-intronENST00000591849ENST00000444181BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000309486ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000309486ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000346315ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000346315ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000351666ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000351666ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000352993ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000352993ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000354071ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000354071ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000357654ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000357654ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000468300ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000468300ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000471181ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000471181ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000491747ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000491747ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000493795ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000493795ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000586385ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000586385ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000591849ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
Frame-shiftENST00000591849ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+
In-frameENST00000591534ENST00000356175BRCA1chr17

41199660

-NF1chr17

29654517

+
In-frameENST00000591534ENST00000358273BRCA1chr17

41199660

-NF1chr17

29654517

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591534BRCA1chr1741199660-ENST00000356175NF1chr1729654517+7816104297342931106
ENST00000591534BRCA1chr1741199660-ENST00000358273NF1chr1729654517+7816104297342931106

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591534ENST00000356175BRCA1chr1741199660-NF1chr1729654517+0.0004665510.9995334
ENST00000591534ENST00000358273BRCA1chr1741199660-NF1chr1729654517+0.0004665510.9995334

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Fusion Genomic Features for BRCA1-NF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BRCA1chr1741199659-NF1chr1729654516+4.30E-060.9999957
BRCA1chr1741199659-NF1chr1729654516+4.30E-060.9999957

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for BRCA1-NF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41199660/chr17:29654517)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRCA1

P38398

NF1

P21359

FUNCTION: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRCA1chr17:41199660chr17:29654517ENST00000352993-2122651_654680722.0Compositional biasNote=Poly-Lys
HgeneBRCA1chr17:41199660chr17:29654517ENST00000357654-2223651_65418221864.0Compositional biasNote=Poly-Lys
HgeneBRCA1chr17:41199660chr17:29654517ENST00000468300-2122651_654693700.0Compositional biasNote=Poly-Lys
HgeneBRCA1chr17:41199660chr17:29654517ENST00000491747-2223651_654718760.0Compositional biasNote=Poly-Lys
HgeneBRCA1chr17:41199660chr17:29654517ENST00000357654-22231642_173618221864.0DomainBRCT 1
HgeneBRCA1chr17:41199660chr17:29654517ENST00000352993-212224_65680722.0Zinc fingerRING-type
HgeneBRCA1chr17:41199660chr17:29654517ENST00000357654-222324_6518221864.0Zinc fingerRING-type
HgeneBRCA1chr17:41199660chr17:29654517ENST00000468300-212224_65693700.0Zinc fingerRING-type
HgeneBRCA1chr17:41199660chr17:29654517ENST00000491747-222324_65718760.0Zinc fingerRING-type
TgeneNF1chr17:41199660chr17:29654517ENST000004313870151352_13550594.0Compositional biasNote=Poly-Ser
TgeneNF1chr17:41199660chr17:29654517ENST000004313870151235_14510594.0DomainRas-GAP
TgeneNF1chr17:41199660chr17:29654517ENST000004313870151580_17380594.0DomainCRAL-TRIO
TgeneNF1chr17:41199660chr17:29654517ENST0000035617535572555_257117352819.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr17:41199660chr17:29654517ENST0000035827336582555_257117562840.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr17:41199660chr17:29654517ENST000004313870152555_25710594.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr17:41199660chr17:29654517ENST000004313870151580_18370594.0RegionNote=Lipid binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRCA1chr17:41199660chr17:29654517ENST00000352993-21221642_1736680722.0DomainBRCT 1
HgeneBRCA1chr17:41199660chr17:29654517ENST00000352993-21221756_1855680722.0DomainBRCT 2
HgeneBRCA1chr17:41199660chr17:29654517ENST00000357654-22231756_185518221864.0DomainBRCT 2
HgeneBRCA1chr17:41199660chr17:29654517ENST00000468300-21221642_1736693700.0DomainBRCT 1
HgeneBRCA1chr17:41199660chr17:29654517ENST00000468300-21221756_1855693700.0DomainBRCT 2
HgeneBRCA1chr17:41199660chr17:29654517ENST00000491747-22231642_1736718760.0DomainBRCT 1
HgeneBRCA1chr17:41199660chr17:29654517ENST00000491747-22231756_1855718760.0DomainBRCT 2
TgeneNF1chr17:41199660chr17:29654517ENST0000035617535571352_135517352819.0Compositional biasNote=Poly-Ser
TgeneNF1chr17:41199660chr17:29654517ENST0000035827336581352_135517562840.0Compositional biasNote=Poly-Ser
TgeneNF1chr17:41199660chr17:29654517ENST0000035617535571235_145117352819.0DomainRas-GAP
TgeneNF1chr17:41199660chr17:29654517ENST0000035617535571580_173817352819.0DomainCRAL-TRIO
TgeneNF1chr17:41199660chr17:29654517ENST0000035827336581235_145117562840.0DomainRas-GAP
TgeneNF1chr17:41199660chr17:29654517ENST0000035827336581580_173817562840.0DomainCRAL-TRIO
TgeneNF1chr17:41199660chr17:29654517ENST0000035617535571580_183717352819.0RegionNote=Lipid binding
TgeneNF1chr17:41199660chr17:29654517ENST0000035827336581580_183717562840.0RegionNote=Lipid binding


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Fusion Gene Sequence for BRCA1-NF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10152_10152_1_BRCA1-NF1_BRCA1_chr17_41199660_ENST00000591534_NF1_chr17_29654517_ENST00000356175_length(transcript)=7816nt_BP=1042nt
TTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCTGCTCTGGGTAAAGGTCATCCCCTTCTAAATGCCCATCATTAGAT
GATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATGTGGAG
GAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGAA
TCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCT
TCAACCTCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTAT
AATGCAATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCT
GGCCTGACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACT
CATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGC
TATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAAC
CACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAACATG
CCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTCACCCTTGGCACAGGTGTCCAC
CCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGGTTGGTTCTACTGCTGTCCAAGTAACTTCAGCAGAGCG
AACAAAAGTCCTAGGGCAATCAGTCTTTCTAAATGACATTTATTATGCTTCGGAAATTGAAGAAATCTGCCTAGTAGATGAGAACCAGTT
CACCTTAACCATTGCAAACCAGGGCACGCCGCTCACCTTCATGCACCAGGAGTGTGAAGCCATTGTCCAGTCTATCATTCATATCCGGAC
CCGCTGGGAACTGTCACAGCCCGACTCTATCCCCCAACACACCAAGATTCGGCCAAAAGATGTCCCTGGGACACTGCTCAATATCGCATT
ACTTAATTTAGGCAGTTCTGACCCGAGTTTACGGTCAGCTGCCTATAATCTTCTGTGTGCCTTAACTTGTACCTTTAATTTAAAAATCGA
GGGCCAGTTACTAGAGACATCAGGTTTATGTATCCCTGCCAACAACACCCTCTTTATTGTCTCTATTAGTAAGACACTGGCAGCCAATGA
GCCACACCTCACGTTAGAATTTTTGGAAGAGTGTATTTCTGGATTTAGCAAATCTAGTATTGAATTGAAACACCTTTGTTTGGAATACAT
GACTCCATGGCTGTCAAATCTAGTTCGTTTTTGCAAGCATAATGATGATGCCAAACGACAAAGAGTTACTGCTATTCTTGACAAGCTGAT
AACAATGACCATCAATGAAAAACAGATGTACCCATCTATTCAAGCAAAAATATGGGGAAGCCTTGGGCAGATTACAGATCTGCTTGATGT
TGTACTAGACAGTTTCATCAAAACCAGTGCAACAGGTGGCTTGGGATCAATAAAAGCTGAGGTGATGGCAGATACTGCTGTAGCTTTGGC
TTCTGGAAATGTGAAATTGGTTTCAAGCAAGGTTATTGGAAGGATGTGCAAAATAATTGACAAGACATGCTTATCTCCAACTCCTACTTT
AGAACAACATCTTATGTGGGATGATATTGCTATTTTAGCACGCTACATGCTGATGCTGTCCTTCAACAATTCCCTTGATGTGGCAGCTCA
TCTTCCCTACCTCTTCCACGTTGTTACTTTCTTAGTAGCCACAGGTCCGCTCTCCCTTAGAGCTTCCACACATGGACTGGTCATTAATAT
CATTCACTCTCTGTGTACTTGTTCACAGCTTCATTTTAGTGAAGAGACCAAGCAAGTTTTGAGACTCAGTCTGACAGAGTTCTCATTACC
CAAATTTTACTTGCTGTTTGGCATTAGCAAAGTCAAGTCAGCTGCTGTCATTGCCTTCCGTTCCAGTTACCGGGACAGGTCATTCTCTCC
TGGCTCCTATGAGAGAGAGACTTTTGCTTTGACATCCTTGGAAACAGTCACAGAAGCTTTGTTGGAGATCATGGAGGCATGCATGAGAGA
TATTCCAACGTGCAAGTGGCTGGACCAGTGGACAGAACTAGCTCAAAGATTTGCATTCCAATATAATCCATCCCTGCAACCAAGAGCTCT
TGTTGTCTTTGGGTGTATTAGCAAACGAGTGTCTCATGGGCAGATAAAGCAGATAATCCGTATTCTTAGCAAGGCACTTGAGAGTTGCTT
AAAAGGACCTGACACTTACAACAGTCAAGTTCTGATAGAAGCTACAGTAATAGCACTAACCAAATTACAGCCACTTCTTAATAAGGACTC
GCCTCTGCACAAAGCCCTCTTTTGGGTAGCTGTGGCTGTGCTGCAGCTTGATGAGGTCAACTTGTATTCAGCAGGTACCGCACTTCTTGA
ACAAAACCTGCATACTTTAGATAGTCTCCGTATATTCAATGACAAGAGTCCAGAGGAAGTATTTATGGCAATCCGGAATCCTCTGGAGTG
GCACTGCAAGCAAATGGATCATTTTGTTGGACTCAATTTCAACTCTAACTTTAACTTTGCATTGGTTGGACACCTTTTAAAAGGGTACAG
GCATCCTTCACCTGCTATTGTTGCAAGAACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATT
TGAAGTGAATACACAGAGCGTGGCCTACTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAA
GTCACTTCTTCTTACTGATATTTCAATGGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAA
GGAGACTCAGCCATGGTCCTCTCCCAAAGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAG
GAAATCCATGAGCCTGGACATGGGGCAACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATC
AGACACAAAGGCTCCTAAAAGGCAAGAAATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAAT
GGAAACTCAGAGGATTTCCTCATCACAACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGT
ACTTACTGATCCGAAGATCCAGGCGCTGCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCT
TTATGAATACTTAGCAGAGGCCAGTGTTGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTT
ATCATTGTGCCAAGATCCAAATTTGTTAAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCA
AACATCTTACCTGCAAAGTTTTGGTTTTAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGA
GCTTATTGTTAAGTTTCTTGATGCCTTGATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCAC
ATCTCCTTACCCTCCTGCACTGCAGAGCCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCA
GCATTCCCCAGGAATCGACAAGGAGAACGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAG
CCAAGTGCAGAAGCAAAGAAGCGCTGGCAGTTTCAAACGTAATAGCATTAAGAAGATCGTGTGAAGCTTGCTTGCTTTCTTTTTTAAAAT
CAACTTAACATGGGCTCTTCACTAGTGACCCCTTCCCTGTCCTTGCCCTTTCCCCCCATGTTGTAATGCTGCACTTCCTGTTTTATAATG
AACCCATCCGGTTTGCCATGTTGCCAGATGATCAACTCTTCGAAGCCTTGCCTAAATTTAATGCTGCCTTTTCTTTAACTTTTTTTCTTC
TACTTTTGGCGTGTATCTGGTATATGTAAGTGTTCAGAACAACTGCAAAGAAAGTGGGAGGTCAGGAAACTTTTAACTGAGAAATCTCAA
TTGTAAGAGAGGATGAATTCTTGAATACTGCTACTACTGGCCAGTGATGAAAGCCATTTGCACAGAGCTCTGCCTTCTGTGGTTTTCCCT
TCTTCATCCTACAGAGTAAAGTGTTAGTCCTATTTATACATTTTTCAAGATACAAGTTTATGAGAGAAATAGTATTATAACCCCAGTATG
TTTAATCTTTTAGCTGTGGACTTTTTTTTTAACCGTACAAAACTGAAAGAACCATAGAGGTCAAGCCTCAGTGACTTGACACCATAAAGC
CACAGACAAGGTACTTGGGGGGGAGGGCAGGGAAATTTCATATTTTATAGTGGATTCTTAAGAAATACTAACACTTGAGTATTAGCAATA
ATTACAGGAAAATAAGTGCGACCACATATATCTTAACATTACTGAATTAAAACTATGGCTTCTAAGTCCTTATCCAAACTCAGTCATCCA
AACTAGTTTATTTTTTTCTCCAGTTGATTATCTTTTAATTTTTAATTTTGCTAAAGGTGGTTTTTTTGTGTTTTGTTTTTTGTAAACCAA
AACTATACTAAGTATAGTAATTATATATATATATATATTTTTTCCCCTCCCCCTCTTCTTTCCTAACTAATTCTGAGCAGGGTAATCAGT
GAACAAAGTGTTGAAAATTGTTCCCAGAAGGTAATTTTCATAGATGTTTGCATTAGCTCCATAGCAAAATGGAATGGTACGTGACATTTA
GGGTAGCTGATATTTTTATTTTGTTAAATAATTTCCAAGAATAGAGTATGGTGTATATTATAAATTTCTTTGATAAGATGTATTTTGAAT
GTCTTTTAATCTTCCTCCTCCTCTCCAAAAAAATCAGAAACCTCTTTAAGAAAACATGTAGGTTATATATGCTAGAATTGCATTTAATCA
CTGTGAAAAGACTGGTCAGCCTGCATTAGTATGACAGTAGGGGGGCTGTTAGAATTGCTGCTATACTGGTGGTATGGATTATCATGGCAT
TGGAATTTTCATAGTAATGCAGATCCAATTTCTTTGTGGTACCTGCAGTTTACAAAATAATTTGACTTCAGTGAGCATATTGGTATCTGG
ATGTTCCAATTTAGAACTAAACCATATTTATTACAAAAAGATATTAATCCCTCTACTCCCAGGTTCCCTTTATATGTTAAGATATAATGG
CTTTGAGGGGGGAAAAAATAAACCTAGGGGAGAGGGGAGTTTCCTGTAGTGCTGTTTCATTAGAGGATTTCAGTAAATTAAATTCCACAG
CTAATTCAATAAATAATGGTACATTTAAGTGTTCTGATTTTAATAATATATTTCACATTTATCCACACAGTAACAATGTAATATGTTAAT
GTAAATAAAATTGGTTTTGATACTCAGAAATAACAAGAATTTAATTTTTTAAATTTGTTTACAGTCCTGGGAAAAGTAAGAATTATTTGC
CAAAATAAGAGGAAAGAAAACCTTAGTATTATTAATGAGTTTACCATAGAATTGTTGGAAATACTGAAGACAGGTGCAATTTACTAAACT
TTTGTTTTTAAACTATTGTAGAGGCTGCATTAGAAGAAAATGTTTATAATGACAGAGCAACTATGACTATATAAAAAAGCTGAAATTAGA
ACTGTGTTTAGAAATAGATCAGTAACCCAGTGCCAAGGATGCCAAGCTGCCACCATGGTCTTGGCTCTCCCACAACCCAGTGTTTCTGGG
GTAAGTTTCACAGTTTCTAGGCCCTGGAATAGCAGGCAGTGTAAGCCTTTGATAACTTTAGTTCGATGTTTTTCTTGTTTTTGTTTGTTG
GTTTGGTGCATATGATAGTGGGTGTTATGCTATTTTGCTCTTCCCATCAAAATAAAGAAACTTCCAGAGGTTTACTGTTAAAAATACTGA
TATTTCCATAAACGGGTTTACCAAGGGTGTAGTATTTCATACCGCCTGAAATGATCAGCATTGGCACAAATCAAAATTCAGCCGCCTTTG
AAATGCAAAAATACCTTTGACTAGTAAGTACATCCTAGGAGTTTGAAAACTTAACTAAGGTTTAAAATTTACCTTGTTTAAAGAACTTCT
GACTTTTGAGGAAAATCTAGCTTTCCAAGTAACTAAAATGTACATGAGATAAACCTCTCACCACTATGTGTCCCTTGAGAAATGCAACAC
TTTTTTAGTCTTCATACTTGTAATCTATAAAAGAAATTCTGAAGTTTAGACCAAGTTGCCCATTTCTGCGTAATTGACATAAGTTCTGTT
AAAAATATTATAAGTAATTCGTTTCGGTTTGTAGATGTTTCCCCTGACTTGTTAAAGAGGAAACCAGGAACTCAGTCATGTTTTTGTCCT
GGATAATCTACCTGTTATGCCAGTACTCCCATCCGAGGGGCATGCCCTTAGTTGCCCAGATGGAGATGCAGTTCAGTAGATTTGGGGCAA
AGTGGCTACAGCTCTGTCTTCCATTCACTCAACACCTGTTCATGACTGAGCCAGGTGCCCAGGACACATCCTAAACAGTCAGCTTCTATC
CTGTGTCCTAGTTGGGGAGACAGAGTGCCAGCCAGCAACCCTCCCAGGTTTGTAGGTTTTAGGGGTTTTCAGTTTTGTTTGGGTTTTTTG
TTTTTTGTTTTTGTTTCTACATCCTTCCCCGACTCCCAGGCATAATGAGGCATGTCTTACTCAATGTTATGCAATGGATTTAGGCAAAAA
TTCATTCTTAGTGTCAGCCACACAATTTTTTTTAATGCAGTATATTCACCTGTAAATAGTTTGTGTAAAATTTGACAAAAAAAGTATATT
TACTATACTGTAAATATATGTGATGATATATTGTATTATTTTGCTTTTTTGTAAAGCAGTTAGTTGCTGCACATGGATAACAACAAAAAT
TTGATTATTCTCGTGTTAGTATTGTTAACTTCTTTTTGCGACTGCGTTACATCATTTAAAGAAAATGCTGTGTATTGTAAACTTAAATTG
TATATGATAACTTACTGTCCTTTCCATCCGGGCCTAAACTTTGGCAGTTCCTTTGTCTACAACCTTGTTAATACTGTAAACAGTTGTACG
CCAGCAGGAAAAATACTGCCCAACAGACAAAATCGATCATTGTAGGGGAAAATCATAGAAATCCATTTCAGATCTTTATTGTTCCTCACC

>10152_10152_1_BRCA1-NF1_BRCA1_chr17_41199660_ENST00000591534_NF1_chr17_29654517_ENST00000356175_length(amino acids)=1106AA_BP=23
MAQVSTQLWLCSQMPGQRTMASMVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIVQS
IIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISK
TLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQI
TDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNS
LDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYR
DRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSK
ALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAI
RNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRC
SLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTRKS
FDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDE
FDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQ
IPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRT

--------------------------------------------------------------
>10152_10152_2_BRCA1-NF1_BRCA1_chr17_41199660_ENST00000591534_NF1_chr17_29654517_ENST00000358273_length(transcript)=7816nt_BP=1042nt
TTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCTGCTCTGGGTAAAGGTCATCCCCTTCTAAATGCCCATCATTAGAT
GATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATGTGGAG
GAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGAA
TCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCT
TCAACCTCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTAT
AATGCAATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCT
GGCCTGACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACT
CATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGC
TATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAAC
CACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAACATG
CCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTCACCCTTGGCACAGGTGTCCAC
CCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGGTTGGTTCTACTGCTGTCCAAGTAACTTCAGCAGAGCG
AACAAAAGTCCTAGGGCAATCAGTCTTTCTAAATGACATTTATTATGCTTCGGAAATTGAAGAAATCTGCCTAGTAGATGAGAACCAGTT
CACCTTAACCATTGCAAACCAGGGCACGCCGCTCACCTTCATGCACCAGGAGTGTGAAGCCATTGTCCAGTCTATCATTCATATCCGGAC
CCGCTGGGAACTGTCACAGCCCGACTCTATCCCCCAACACACCAAGATTCGGCCAAAAGATGTCCCTGGGACACTGCTCAATATCGCATT
ACTTAATTTAGGCAGTTCTGACCCGAGTTTACGGTCAGCTGCCTATAATCTTCTGTGTGCCTTAACTTGTACCTTTAATTTAAAAATCGA
GGGCCAGTTACTAGAGACATCAGGTTTATGTATCCCTGCCAACAACACCCTCTTTATTGTCTCTATTAGTAAGACACTGGCAGCCAATGA
GCCACACCTCACGTTAGAATTTTTGGAAGAGTGTATTTCTGGATTTAGCAAATCTAGTATTGAATTGAAACACCTTTGTTTGGAATACAT
GACTCCATGGCTGTCAAATCTAGTTCGTTTTTGCAAGCATAATGATGATGCCAAACGACAAAGAGTTACTGCTATTCTTGACAAGCTGAT
AACAATGACCATCAATGAAAAACAGATGTACCCATCTATTCAAGCAAAAATATGGGGAAGCCTTGGGCAGATTACAGATCTGCTTGATGT
TGTACTAGACAGTTTCATCAAAACCAGTGCAACAGGTGGCTTGGGATCAATAAAAGCTGAGGTGATGGCAGATACTGCTGTAGCTTTGGC
TTCTGGAAATGTGAAATTGGTTTCAAGCAAGGTTATTGGAAGGATGTGCAAAATAATTGACAAGACATGCTTATCTCCAACTCCTACTTT
AGAACAACATCTTATGTGGGATGATATTGCTATTTTAGCACGCTACATGCTGATGCTGTCCTTCAACAATTCCCTTGATGTGGCAGCTCA
TCTTCCCTACCTCTTCCACGTTGTTACTTTCTTAGTAGCCACAGGTCCGCTCTCCCTTAGAGCTTCCACACATGGACTGGTCATTAATAT
CATTCACTCTCTGTGTACTTGTTCACAGCTTCATTTTAGTGAAGAGACCAAGCAAGTTTTGAGACTCAGTCTGACAGAGTTCTCATTACC
CAAATTTTACTTGCTGTTTGGCATTAGCAAAGTCAAGTCAGCTGCTGTCATTGCCTTCCGTTCCAGTTACCGGGACAGGTCATTCTCTCC
TGGCTCCTATGAGAGAGAGACTTTTGCTTTGACATCCTTGGAAACAGTCACAGAAGCTTTGTTGGAGATCATGGAGGCATGCATGAGAGA
TATTCCAACGTGCAAGTGGCTGGACCAGTGGACAGAACTAGCTCAAAGATTTGCATTCCAATATAATCCATCCCTGCAACCAAGAGCTCT
TGTTGTCTTTGGGTGTATTAGCAAACGAGTGTCTCATGGGCAGATAAAGCAGATAATCCGTATTCTTAGCAAGGCACTTGAGAGTTGCTT
AAAAGGACCTGACACTTACAACAGTCAAGTTCTGATAGAAGCTACAGTAATAGCACTAACCAAATTACAGCCACTTCTTAATAAGGACTC
GCCTCTGCACAAAGCCCTCTTTTGGGTAGCTGTGGCTGTGCTGCAGCTTGATGAGGTCAACTTGTATTCAGCAGGTACCGCACTTCTTGA
ACAAAACCTGCATACTTTAGATAGTCTCCGTATATTCAATGACAAGAGTCCAGAGGAAGTATTTATGGCAATCCGGAATCCTCTGGAGTG
GCACTGCAAGCAAATGGATCATTTTGTTGGACTCAATTTCAACTCTAACTTTAACTTTGCATTGGTTGGACACCTTTTAAAAGGGTACAG
GCATCCTTCACCTGCTATTGTTGCAAGAACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATT
TGAAGTGAATACACAGAGCGTGGCCTACTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAA
GTCACTTCTTCTTACTGATATTTCAATGGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAA
GGAGACTCAGCCATGGTCCTCTCCCAAAGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAG
GAAATCCATGAGCCTGGACATGGGGCAACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATC
AGACACAAAGGCTCCTAAAAGGCAAGAAATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAAT
GGAAACTCAGAGGATTTCCTCATCACAACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGT
ACTTACTGATCCGAAGATCCAGGCGCTGCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCT
TTATGAATACTTAGCAGAGGCCAGTGTTGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTT
ATCATTGTGCCAAGATCCAAATTTGTTAAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCA
AACATCTTACCTGCAAAGTTTTGGTTTTAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGA
GCTTATTGTTAAGTTTCTTGATGCCTTGATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCAC
ATCTCCTTACCCTCCTGCACTGCAGAGCCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCA
GCATTCCCCAGGAATCGACAAGGAGAACGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAG
CCAAGTGCAGAAGCAAAGAAGCGCTGGCAGTTTCAAACGTAATAGCATTAAGAAGATCGTGTGAAGCTTGCTTGCTTTCTTTTTTAAAAT
CAACTTAACATGGGCTCTTCACTAGTGACCCCTTCCCTGTCCTTGCCCTTTCCCCCCATGTTGTAATGCTGCACTTCCTGTTTTATAATG
AACCCATCCGGTTTGCCATGTTGCCAGATGATCAACTCTTCGAAGCCTTGCCTAAATTTAATGCTGCCTTTTCTTTAACTTTTTTTCTTC
TACTTTTGGCGTGTATCTGGTATATGTAAGTGTTCAGAACAACTGCAAAGAAAGTGGGAGGTCAGGAAACTTTTAACTGAGAAATCTCAA
TTGTAAGAGAGGATGAATTCTTGAATACTGCTACTACTGGCCAGTGATGAAAGCCATTTGCACAGAGCTCTGCCTTCTGTGGTTTTCCCT
TCTTCATCCTACAGAGTAAAGTGTTAGTCCTATTTATACATTTTTCAAGATACAAGTTTATGAGAGAAATAGTATTATAACCCCAGTATG
TTTAATCTTTTAGCTGTGGACTTTTTTTTTAACCGTACAAAACTGAAAGAACCATAGAGGTCAAGCCTCAGTGACTTGACACCATAAAGC
CACAGACAAGGTACTTGGGGGGGAGGGCAGGGAAATTTCATATTTTATAGTGGATTCTTAAGAAATACTAACACTTGAGTATTAGCAATA
ATTACAGGAAAATAAGTGCGACCACATATATCTTAACATTACTGAATTAAAACTATGGCTTCTAAGTCCTTATCCAAACTCAGTCATCCA
AACTAGTTTATTTTTTTCTCCAGTTGATTATCTTTTAATTTTTAATTTTGCTAAAGGTGGTTTTTTTGTGTTTTGTTTTTTGTAAACCAA
AACTATACTAAGTATAGTAATTATATATATATATATATTTTTTCCCCTCCCCCTCTTCTTTCCTAACTAATTCTGAGCAGGGTAATCAGT
GAACAAAGTGTTGAAAATTGTTCCCAGAAGGTAATTTTCATAGATGTTTGCATTAGCTCCATAGCAAAATGGAATGGTACGTGACATTTA
GGGTAGCTGATATTTTTATTTTGTTAAATAATTTCCAAGAATAGAGTATGGTGTATATTATAAATTTCTTTGATAAGATGTATTTTGAAT
GTCTTTTAATCTTCCTCCTCCTCTCCAAAAAAATCAGAAACCTCTTTAAGAAAACATGTAGGTTATATATGCTAGAATTGCATTTAATCA
CTGTGAAAAGACTGGTCAGCCTGCATTAGTATGACAGTAGGGGGGCTGTTAGAATTGCTGCTATACTGGTGGTATGGATTATCATGGCAT
TGGAATTTTCATAGTAATGCAGATCCAATTTCTTTGTGGTACCTGCAGTTTACAAAATAATTTGACTTCAGTGAGCATATTGGTATCTGG
ATGTTCCAATTTAGAACTAAACCATATTTATTACAAAAAGATATTAATCCCTCTACTCCCAGGTTCCCTTTATATGTTAAGATATAATGG
CTTTGAGGGGGGAAAAAATAAACCTAGGGGAGAGGGGAGTTTCCTGTAGTGCTGTTTCATTAGAGGATTTCAGTAAATTAAATTCCACAG
CTAATTCAATAAATAATGGTACATTTAAGTGTTCTGATTTTAATAATATATTTCACATTTATCCACACAGTAACAATGTAATATGTTAAT
GTAAATAAAATTGGTTTTGATACTCAGAAATAACAAGAATTTAATTTTTTAAATTTGTTTACAGTCCTGGGAAAAGTAAGAATTATTTGC
CAAAATAAGAGGAAAGAAAACCTTAGTATTATTAATGAGTTTACCATAGAATTGTTGGAAATACTGAAGACAGGTGCAATTTACTAAACT
TTTGTTTTTAAACTATTGTAGAGGCTGCATTAGAAGAAAATGTTTATAATGACAGAGCAACTATGACTATATAAAAAAGCTGAAATTAGA
ACTGTGTTTAGAAATAGATCAGTAACCCAGTGCCAAGGATGCCAAGCTGCCACCATGGTCTTGGCTCTCCCACAACCCAGTGTTTCTGGG
GTAAGTTTCACAGTTTCTAGGCCCTGGAATAGCAGGCAGTGTAAGCCTTTGATAACTTTAGTTCGATGTTTTTCTTGTTTTTGTTTGTTG
GTTTGGTGCATATGATAGTGGGTGTTATGCTATTTTGCTCTTCCCATCAAAATAAAGAAACTTCCAGAGGTTTACTGTTAAAAATACTGA
TATTTCCATAAACGGGTTTACCAAGGGTGTAGTATTTCATACCGCCTGAAATGATCAGCATTGGCACAAATCAAAATTCAGCCGCCTTTG
AAATGCAAAAATACCTTTGACTAGTAAGTACATCCTAGGAGTTTGAAAACTTAACTAAGGTTTAAAATTTACCTTGTTTAAAGAACTTCT
GACTTTTGAGGAAAATCTAGCTTTCCAAGTAACTAAAATGTACATGAGATAAACCTCTCACCACTATGTGTCCCTTGAGAAATGCAACAC
TTTTTTAGTCTTCATACTTGTAATCTATAAAAGAAATTCTGAAGTTTAGACCAAGTTGCCCATTTCTGCGTAATTGACATAAGTTCTGTT
AAAAATATTATAAGTAATTCGTTTCGGTTTGTAGATGTTTCCCCTGACTTGTTAAAGAGGAAACCAGGAACTCAGTCATGTTTTTGTCCT
GGATAATCTACCTGTTATGCCAGTACTCCCATCCGAGGGGCATGCCCTTAGTTGCCCAGATGGAGATGCAGTTCAGTAGATTTGGGGCAA
AGTGGCTACAGCTCTGTCTTCCATTCACTCAACACCTGTTCATGACTGAGCCAGGTGCCCAGGACACATCCTAAACAGTCAGCTTCTATC
CTGTGTCCTAGTTGGGGAGACAGAGTGCCAGCCAGCAACCCTCCCAGGTTTGTAGGTTTTAGGGGTTTTCAGTTTTGTTTGGGTTTTTTG
TTTTTTGTTTTTGTTTCTACATCCTTCCCCGACTCCCAGGCATAATGAGGCATGTCTTACTCAATGTTATGCAATGGATTTAGGCAAAAA
TTCATTCTTAGTGTCAGCCACACAATTTTTTTTAATGCAGTATATTCACCTGTAAATAGTTTGTGTAAAATTTGACAAAAAAAGTATATT
TACTATACTGTAAATATATGTGATGATATATTGTATTATTTTGCTTTTTTGTAAAGCAGTTAGTTGCTGCACATGGATAACAACAAAAAT
TTGATTATTCTCGTGTTAGTATTGTTAACTTCTTTTTGCGACTGCGTTACATCATTTAAAGAAAATGCTGTGTATTGTAAACTTAAATTG
TATATGATAACTTACTGTCCTTTCCATCCGGGCCTAAACTTTGGCAGTTCCTTTGTCTACAACCTTGTTAATACTGTAAACAGTTGTACG
CCAGCAGGAAAAATACTGCCCAACAGACAAAATCGATCATTGTAGGGGAAAATCATAGAAATCCATTTCAGATCTTTATTGTTCCTCACC

>10152_10152_2_BRCA1-NF1_BRCA1_chr17_41199660_ENST00000591534_NF1_chr17_29654517_ENST00000358273_length(amino acids)=1106AA_BP=23
MAQVSTQLWLCSQMPGQRTMASMVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIVQS
IIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISK
TLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQI
TDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNS
LDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYR
DRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSK
ALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAI
RNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRC
SLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTRKS
FDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDE
FDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQ
IPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRT

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Fusion Gene PPI Analysis for BRCA1-NF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneBRCA1chr17:41199660chr17:29654517ENST00000357654-22231397_14241822.33333333333331864.0PALB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneBRCA1chr17:41199660chr17:29654517ENST00000352993-21221397_1424680.3333333333334722.0PALB2
HgeneBRCA1chr17:41199660chr17:29654517ENST00000468300-21221397_1424693.6666666666666700.0PALB2
HgeneBRCA1chr17:41199660chr17:29654517ENST00000491747-22231397_1424718.3333333333334760.0PALB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRCA1-NF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRCA1-NF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource